CN104288270A - Traditional Chinese medicine composition for treating thrombophlebitis, and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating thrombophlebitis, and preparation method thereof Download PDF

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CN104288270A
CN104288270A CN201410181801.2A CN201410181801A CN104288270A CN 104288270 A CN104288270 A CN 104288270A CN 201410181801 A CN201410181801 A CN 201410181801A CN 104288270 A CN104288270 A CN 104288270A
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chinese medicine
medicine composition
thrombophlebitis
treatment
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CN104288270B (en
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赵建龙
邱相君
连建学
李珂
吴银萍
王晓兰
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Henan University of Science and Technology
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Abstract

The invention discloses a traditional Chinese medicine composition for treating thrombophlebitis, and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is composed of the following raw materials by weight: 10-20 parts of poria, 10-15 parts of white atractylodes rhizome, 5-15 parts of radix codonopsis, 20-30 parts of radix astragali, 15-20 parts of Chinese angelica root, 10-20 parts of red peony root, 5-15 parts of peach kernels, 5-15 parts of safflower, 5-15 parts of sappanwood, 10-20 parts of cassia twig, 15-20 parts of honeysuckle, 10-20 parts of rhizoma corydalis and 10-20 parts of melia toosendan. On basis of a theory of traditional Chinese medicine, the traditional Chinese medicine composition combines a formula according to a sovereign, minister, assistant and envoy principle. In the formula, the poria, radix codonopsis and safflower are used as sovereign drugs which have the function of activating blood to resolve stasis; the honeysuckle, rhizoma corydalis and melia toosenedan are used as minister drugs which have the function of regulating lipid; and the red peony root, peach kernels and cassia twig are used as envoy drugs which have the functions of coordinating all the drugs, dispersing swelling and enhancing immunity of a patient. The traditional Chinese medicine composition is mainly used for treating the thrombophlebitis, particularly for sore symptoms of a thrombophlebitis patient, and has a definite curative effect.

Description

A kind of Chinese medicine composition being used for the treatment of thrombophlebitis and preparation method thereof
Technical field
The present invention is specifically related to a kind of Chinese medicine composition being used for the treatment of thrombophlebitis, and the preparation method of this Chinese medicine composition, belongs to technical field of Chinese medicine.
Background technology
Thrombophlebitis is the commonly encountered diseases of peripheral-vascular, accompanies thrombosis by the inflammation in venous lumen simultaneously.Clinical manifestation is limbs local swelling, and color of the leather is secretly blue or green, blood stasis and pain.Thrombophlebitis belongs to the categories such as the superficial obstructive phlebitis of Chinese medicine, blood vessel, yellow loach pain, table snake venom, and the factors such as the generation of primary disease is manyly stagnated by damp-heat accumulation, cold temperature, wound passages through which vital energy circulates of it is generally acknowledged cause QI and blood to be driven in the wrong direction in smooth, stasis arteries and veins.There are some researches prove all kinds thrombophlebitis blood samples of patients all in hypercoagulability, blood denseness increases, slow blood flow is thrombotic pathologic basis, after thrombosis, the secondary hemopoietic bolt of proximad expansion and distally procreation, excite the inflammation around wall of vein and vein with blood vessel wall adhesion gradually, thus form thrombotic.
At present, the treatment by Chinese herbs method of clinical treatment thrombophlebitis master comprises quiet of interior oral administration, application and Chinese medicine.The multiple blood-activating stasis-removing kind Chinese medicine of the many uses of interior oral administration is as Radix Notoginseng etc., and the Chinese medicine of many some irritation effect of use of application is as Fructus Capsici, and these two kinds of Therapeutic Method all exist the shortcoming that uncertain therapeutic efficacy is cut, treatment cycle is long.Using Radix Notoginseng, the components in danshen Chinese medicine with function of promoting blood circulation to disperse blood clots quiet more, the method is rapid-action, but there is certain bleeding risk when the long period uses in such Chinese medicine, and its exist use inconvenient, costly, the defect that easily recurs of drug withdrawal.Clinical for meeting better, urgently a kind of curative effect certainly, toxic and side effects little, easy to use and patient's economic capability Chinese medicine preparation for the treatment of thrombophlebitis that can bear.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition being used for the treatment of thrombophlebitis.
Meanwhile, the present invention also provides a kind of preparation method being used for the treatment of the Chinese medicine composition of thrombophlebitis.
In order to realize above object, the technical solution adopted in the present invention is:
Be used for the treatment of a Chinese medicine composition for thrombophlebitis, be made up of the crude drug of following parts by weight: Poria 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Radix Codonopsis 5 ~ 15 parts, the Radix Astragali 20 ~ 30 parts, Radix Angelicae Sinensis 15 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, 5 ~ 15 parts, Semen Persicae, 5 ~ 15 parts, Flos Carthami, Lignum Sappan 5 ~ 15 parts, Ramulus Cinnamomi 10 ~ 20 parts, Flos Lonicerae 15 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Fructus Toosendan 10 ~ 20 parts.
Preferably, be used for the treatment of the Chinese medicine composition of thrombophlebitis, be made up of the crude drug of following parts by weight: Poria 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Codonopsis 10 parts, the Radix Astragali 25 parts, Radix Angelicae Sinensis 18 parts, Radix Paeoniae Rubra 15 parts, 10 parts, Semen Persicae, 10 parts, Flos Carthami, Lignum Sappan 10 parts, Ramulus Cinnamomi 15 parts, Flos Lonicerae 18 parts, Rhizoma Corydalis 15 parts, Fructus Toosendan 12 parts.
Each crude drug effect is summarized as follows:
Poria: for Polyporaceae hole of crouching belongs to the sclerotium of fungus Poria; Containing triterpenes as pachymic acid, 16 Alpha-hydroxy eburicoic acids, β-para hydroxybenzene acyl group dehydroeburicoic acid etc., polysaccharide as the callose etc. of pachyman, pachymaran and height, branch, also containing the various active composition such as ergosterol, sad, hendecanoic acid, lauric acid, dodecenoic acid, Palmic acid, dodecenoic acid fat, sad fat and inorganic elements; Nature and flavor are sweet, light, flat, GUIXIN, spleen, lung, kidney channel; Energy promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming; Cure mainly dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite, have loose bowels, palpitation and restlessness, insomnia forgetfulness etc.; Modern pharmacology proves that Poria has diuresis, anticancer and immunological enhancement etc.
The Rhizoma Atractylodis Macrocephalae: be the rhizome of the Compositae [WTBX plant Rhizoma Atractylodis Macrocephalae; Containing volatile oil as atractylone, α and β-Humuleno, α-curcumene, Palmic acid, hinesol etc., sesquiterpene lactones compound is as atractyloide-I, II, III, IV etc., polyacetylene alcohol compound, also containing scopoletin, there is immunocompetent mannan AM-3, and more than ten seed amino acid such as aspartic acid, serine; Rhizoma Atractylodis Macrocephalae nature and flavor are bitter, sweet, and temperature, returns spleen, stomach warp; Can invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive; Cure mainly weak, the lack of appetite abdominal distention of deficiency-weakness of spleen-QI, have loose bowels, constipation, fluid-retention stagnating in the interior dysuria, edema, dizziness due to fluid-retention, Korean style numbness, general pain, spontaneous sweating due to deficiency of QI etc.; Modern pharmacology proves the effects such as the Rhizoma Atractylodis Macrocephalae has antioxidation and slow down aging, antitumor, blood sugar lowering, diuresis and anti-ascites, protects the liver, function of gallbladder promoting, can also facilitating digestion system, immune system, cardiac muscle and cardiovascular system.
Radix Codonopsis: be the root of campanulaceae Codonopsis plant Radix Codonopsis, element flower Radix Codonopsis, radix codonpsis tangshen, pipe flower Radix Codonopsis, C. subglobosa, C. canescens; Containing saccharide as fructose, inulin, polysaccharide and 4 kinds of heteropolysaccharide CP 1, CP 2, CP 3, CP 4glycoside is as ligustrin, n-hexyl-β-pyranglucoside, ethyl-α-D-fructofuranoside, tangshenoside, alkaloid and nitrogen containing component, as choline, loline etc., also contain the various active compositions such as syringic aldehyde, vanillic acid, pyromucic acid, atractyloide I, II; Radix Codonopsis nature and flavor are sweet, flat, return spleen, lung meridian; Energy strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid; Cure mainly weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung are breathed with cough, all cards of spontaneous perspiration of breathing hard, deficiency of both QI and blood; Modern pharmacology proves that Radix Codonopsis has enhancing body stress ability, enhancing human body immunity function, slow down aging, antiulcer, antitumor assosting effect etc.
The Radix Astragali: be the root of pulse family Astragalus Radix Astagali and Radix Astragali; Containing saponin component as astragaloside, isoflavones components is as calycosin, and fatty acid is as Palmic acid and linoleic acid, and polysaccharide is as astragalus polysaccharides, heteropolysaccharide etc., and nearly 20 various trace elements; Radix Astragali nature and flavor are sweet, and temperature, returns lung, spleen channel; Energy benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening; Cure mainly the disease of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle difficulty is burst or is burst for a long time and do not hold back; Modern pharmacology proves that the Radix Astragali can affect organism metabolism, has the effects such as antioxidation, antithrombotic, antiviral, arthritis, anticancer, anti-inflammatory and antalgic, can also protect cardio-cerebrovascular and promote hemopoietic function.
Radix Angelicae Sinensis (Radix Angelicae Sinensis): when being classified as the root of Umbelliferae archangel Radix Angelicae Sinensis; Containing multiple volatile oil and organic acid, also containing more than 20 kind of inorganic elements and polysaccharide composition; Radix Angelicae Sinensis nature and flavor are sweet, pungent, bitter, and temperature, returns liver, the heart, spleen channel; Can enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation; Cure mainly all cards of blood deficiency, menoxenia, amenorrhea, dysmenorrhea ， mass in the abdomen knot is poly-, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, heavy after bloody dysentery, ulcer sores, injury from falling down etc.; Modern pharmacology proves that Radix Angelicae Sinensis can affect blood and hemopoietic system, has the effects such as blood fat reducing, arteriosclerosis, radioprotective, antitumor, anti-inflammatory and antalgic, antibody Monoclonal.Radix Angelicae Sinensis refers to the afterbody of Radix Angelicae Sinensis, has the effect such as blood circulation promoting and blood stasis dispelling, removing blood stasis, is applied to the stagnant disease such as to swell and ache of the obstructed and blood stasis of amenorrhea
Radix Paeoniae Rubra: be the root of Paeoniaceae Paeonia plant peony, river Radix Paeoniae Rubra; Containing monoterpenes as Radix Paeoniae Rubra glycosides, oxidation Radix Paeoniae Rubra glycosides etc., organic acid, as benzoic acid, gallic acid etc., also contains the plurality of active ingredients such as catechin, cupreol; Nature and flavor are bitter, be slightly cold, and return Liver Channel; Energy clearing away heat and cooling blood, clots absorbing pain relieving, dissipating blood stasis for subsidence of swelling; Cure mainly amenorrhea dysmenorrhea, hernia abdominal mass gathered, maculae caused by violent heat pathogen, hematemesis and epistaxis, hypochondriac pain due to stagnation of liverQI, discharging fresh blood stool, conjunctival congestion and swelling pain, injury from falling down, carbuncle skin infection, can be used for the diseases such as amenorrhea; Modern pharmacology proves that Radix Paeoniae Rubra has antithrombotic, antiplatelet aggregation, arteriosclerosis, the effect such as to protect the liver.
Semen Persicae: be the seed of Rosaceae peach family plant seed Fructus Persicae or Prunus davidiana; Containing amygdaloside, Virginia prune glucoside etc., sterols is as cupreol, campesterol etc., and organic acid is if chlorogenic acid, 3-caffeoylquinic acid, 3-are to coumaric acyl quininic acid, triolein, oleic acid and linoleic acid etc., and protein is as PR-A and PR-B etc.; Nature and flavor are bitter, sweet, GUIXIN, liver, large intestine channel; Energy blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation; Cure mainly dysmenorrhea, amenorrhea due to stagnation of blood, the stasis of blood in puerperal stagnant stomachache, mass in the abdomen caking, traumatic injury, swelling and pain due to blood stasis, lung abscess, acute appendicitis, dryness of the intestine constipation etc.; Modern pharmacology proves that Semen Persicae has anticoagulation, antithrombus formation, antiinflammatory, eliminating phlegm and stopping cough, antitumor action etc.
Flos Carthami: be the flower of Compositae Flos Carthami platymiscium Flos Carthami; Containing flavone compound as saffloside, front saffloside, safflower yellow A, B etc., Polyphenols is as chlorogenic acid, caffeic acid, catechol etc., also plant volatile ingredient as methyl cinnamate, Flos Caryophylli alkene, Flos Caryophylli alkene epoxide etc. containing more than 80, and 16 seed amino acid as lysine, fatty acid is as Palmic acid, myristic acid, lauric acid, oleic acid etc., another containing Flos Carthami polysaccharide and other multiple active components; Nature and flavor are pungent, warm, GUIXIN, Liver Channel; Energy promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing; Cure mainly blood stasis amenorrhea, dysmenorrhea, postpartum stagnation stomachache, obstruction of qi in the chest and cardialgia, lumps in the chest and abdomen, traumatic injury, arthralgia, apoplectic hemiplegia etc.; Modern pharmacology proves that Flos Carthami has anticoagulation, antiinflammatory, antioxidation etc.
Lignum Sappan: be the heartwood of pulse family divi divi platymiscium Lignum Sappan; Containing chromanane compounds as 3-deoxidation hematoxylone B, Lignum Sappan phenol, table Lignum Sappan phenol etc., also containing brazilin, brazilin derivant 1 and 2, contain again flavones ingredient as ombuin, rhamnetin, Quercetin etc., the another dibenzo oxepane compounds that contains is as protosappanin A, the former haematoxylin B of B, D, E-1, E-2 and 10-O-methyl, and Lignum Sappan bitter principle J and P, octacosanol, cupreol and taraxerol etc.; Nature and flavor are sweet, salty, micro-pungent, flat, GUIXIN, liver, large intestine channel; Energy blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain; Cure mainly married woman's amenorrhea due to stagnation of blood, dysmenorrhea, postpartum stagnation cardiac and abdominal pain, puerperal blood faints, carbuncle, traumatic injury, tetanus etc.; Modern pharmacology proves that Lignum Sappan has anticancer, immunosuppressant and anti-rejection effect, also has an impact to blood and blood circulation.
Ramulus Cinnamomi: be the twig of Lauraceae cinnamon Cortex Cinnamomi; Containing volatile oil as cinnamic aldehyde, benzyl benzoate, cinnamyl acetate, β-cadinene, Rhizoma Acori Graminei alkene, coumarin, cinnamic acid, o-methoxy-3-phenyl-2-propenoic acid, 1,4-diphenyl-diacetyl, syringic aldehyde, steroid is as cupreol, 5 α, 8 α-Ergosterol Peroxide, 6 beta-hydroxy-4-alkene-3-stigmasterones, again containing protocatechuic acid, daucosterol etc.; Nature and flavor acrid, sweet, warm, return bladder, the heart, lung meridian; Can expelling cold and relieving exterior syndrome, warming the meridian, activate yang; Cure mainly wind and cold sign, arthralgia due to cold-dampnes, extreme cold of the limbs, amenorrhea dysmenorrhea, mass in the abdomen caking, the thoracic obstruction, cardiopalmus, phlegm retention, dysuria etc.; Modern pharmacology proves that Ramulus Cinnamomi has the effects such as antibacterial, antiviral, antipyretic, analgesia, calmness, convulsion, antiinflammatory.
Flos Lonicerae (Radix Ophiopogonis): be the alabastrum of Caprifoliaceae woodbine Radix Ophiopogonis, Lonicera confusa, wild rice gland Radix Ophiopogonis, Lonicera fulvotnetosa Hsu et S. C. Cheng. Ms; Containing phenolic acids as chlorogenic acid, isochlorogenic acid, sterols is as cupreol, and volatile oil is as linalool, ethyl palmitate, ethyl linolenate etc., and flavonoid is as plurality of active ingredients such as luteoloside, xylostein, hyperins; Flos Lonicerae nature and flavor are sweet, cold; Attach to the lung and stomach meridians; Energy heat-clearing and toxic substances removing; Cure mainly affection due to external wind and heat or epidemic febrile disease heating, heatstroke, toxic-heat and blood stasis, carbuncle furuncle, sore throat, multi-infection disease etc.; Modern pharmacology proves that Flos Lonicerae has the effects such as resisting pathogenic microbes, antitoxin, antiinflammatory, blood fat reducing, serum cholesterol (Tc) and atherogenic index (AI) can also be reduced, improve high density lipoprotein level-cholesterol (HDL-C) content.
Rhizoma Corydalis (Rhizoma Corydalis, Rhizoma Corydalis): be the tuber of Papaveraceae Genus Corydalis Rhizoma Corydalis, containing dextrorotation corydaline (Corydaline), Tetrahydropalmatine (tetrahydropalmatine), l-Tetrahydrocoptisine (Rhizoma Corydalis D prime), palmatine, dehydroglaucin, protopine (Rhizoma Corydalis C prime), dextrorotation is papaverine also, α-allocryptopine (Rhizoma Corydalis Kui prime), left-handed tetrahydrocolumbamine, dextrorotation corybulbine, 13-Methylpalmatine, left-handed N-1, Columbamine, dextrorotation-N-methyllaurotetanine, yuanhunine, leonticine, 13-methyl-13,14-dihydro-[1,3, dehydrogenation nandinine, bicuculline, cryptocavine, the multiple alkaloid such as coptisine and berberine, nature and flavor are pungent, bitter, temperature, GUIXIN, liver, spleen channel, energy promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain, cure mainly obstruction of qi in the chest and cardialgia, epigastric pain, lumbago, colicky, dysmenorrhea, amenorrhea, mass in the abdomen, the stagnant stomachache of the stasis of blood in puerperal, traumatic injury etc., modern pharmacology proves that Rhizoma Corydalis has analgesia, hypnosis, calmness, stabilizes, coronary artery dilator, suppression heart, arrhythmia, antiulcer, anticoagulant, Ca2+ overloading, antioxidation, the effect such as raising learning capacity.
Fructus Toosendan (chinaberry is real): be the fruit of Meliaceae melia plant Fructus Toosendan; Containing Triterpenoid as Toosendanin, Fructus Toosendan ketone, ester melianol, 21-O-acetyl Fructus Toosendan triol, 21-O-methyl Fructus Toosendan pentol, violet incense ketoside, isochuanliansu, Fructus Toosendan element first and the second grade, phenylpropyl alcohol triol glycosides, as Fructus Toosendan glycosides A and B, also contains n-Triacontanoic acid, n-dotriacontanol, Palmiticacid etc.; Nature and flavor are bitter, cold, and mild toxicity, returns liver, stomach, small intestine meridian; Energy is soothing the liver to expel the heat-evil, promoting the circulation of QI to relieve pain, parasite killing; Cure mainly the gastral cavity abdomen pain over the hypochondriac region, hernia pain, abdominal pain due to worm stagnation, tinea capitis etc.; Modern pharmacology proves that Fructus Toosendan has transmission between block nerves neuromuscular junction, ascarifuge, the effect such as antibacterial.
Be used for the treatment of a Chinese medicine composition for thrombophlebitis, conventional method can be adopted to be prepared into the form of Chinese drug such as oral liquid, granule, powder, pill, tablet, capsule, drink after also can directly brewing.The change of dosage form does not affect the therapeutic effect of Chinese medicine composition.The present invention provides the preparation method of a kind of oral liquid and honeyed pill respectively.
Be used for the treatment of a preparation method for the Chinese medicine composition of thrombophlebitis, comprise the following steps: accurately get each crude drug according to parts by weight, add the water soaking of 3 ~ 5 times amount, concentrate after temperature fire decocts and obtain oral liquid.
Be used for the treatment of a preparation method for the Chinese medicine composition of thrombophlebitis, comprise the following steps: accurately get each crude drug according to parts by weight, pulverize, sieve after fine powder; Get fine powder and carry out sterilization treatment; Honey in adding in the fine powder of sterilizing, after heating mixing, refine obtains honeyed pill.
Described sieves as crossing 100 ~ 120 mesh sieves.
Described sterilising conditions is: sterilization treatment 25 ~ 35 minutes at 95 ~ 110 DEG C.
Described middle honey can be commercial goods, and conventional method also can be adopted to prepare; The addition of middle honey is 15 ~ 20% of fine powder quality.
Described heating-up temperature is 50 ~ 60 DEG C.
Beneficial effect of the present invention:
The present invention, according to theory of Chinese medical science, according to monarch principle composition of prescription, chooses the totally 13 taste pure natural Chinese herbal medicine such as Poria, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, and in side, Poria, Radix Codonopsis, Flos Carthami are monarch drug, have effect of blood circulation promoting and blood stasis dispelling; Flos Lonicerae, Rhizoma Corydalis, Fructus Toosendan are ministerial drug, and tool adjusts effect of fat; Radix Paeoniae Rubra, Semen Persicae, Ramulus Cinnamomi, for making medicine, have coordinating the actions of various ingredients in a prescription, detumescence and strengthen effect of patient's resistance; Its formula is reasonable, emphasizes organic conception, is mainly used in treating thrombophlebitis, especially for the symptom that swells and ache of thrombophlebitis patient, and determined curative effect.The present invention adopts pure natural Chinese herbal medicine not add any chemicals, and long-term taking is several to have no side effect, and Chinese crude drug source is wide, cheap, economical and practical.
The preparation method being used for the treatment of the Chinese medicine composition of thrombophlebitis in the present invention is simple, and production cost is low, is suitable for large-scale industrial production and application.
Detailed description of the invention
Following embodiment is only described in further detail the present invention, but does not form any limitation of the invention.
Embodiment 1
Be used for the treatment of the Chinese medicine composition of thrombophlebitis in the present embodiment, be made up of the crude drug of following weight: Poria 10 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Codonopsis 5 grams, the Radix Astragali 30 grams, Radix Angelicae Sinensis 15 grams, Radix Paeoniae Rubra 20 grams, 5 grams, Semen Persicae, 15 grams, Flos Carthami, Lignum Sappan 5 grams, Ramulus Cinnamomi 20 grams, Flos Lonicerae 15 grams, Rhizoma Corydalis 20 grams, Fructus Toosendan 10 grams.
Be used for the treatment of the preparation method of the Chinese medicine composition of thrombophlebitis in the present embodiment, comprise the following steps: accurately get each crude drug according to weight, after adding the water soaking of 5 times amount, temperature fire decocts, and is concentrated into 300ml and namely obtains oral liquid.
The usage of oral liquid and consumption: oral, one day twice, a 50ml 15 days is a course for the treatment of, one after each meal.
Embodiment 2
Be used for the treatment of the Chinese medicine composition of thrombophlebitis in the present embodiment, be made up of the crude drug of following weight: Poria 10 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Radix Codonopsis 5 grams, the Radix Astragali 20 grams, Radix Angelicae Sinensis 15 grams, Radix Paeoniae Rubra 10 grams, 5 parts, Semen Persicae, 5 grams, Flos Carthami, Lignum Sappan 5 grams, Ramulus Cinnamomi 10 grams, Flos Lonicerae 15 grams, Rhizoma Corydalis 10 grams, Fructus Toosendan 10 grams.
Be used for the treatment of the preparation method of the Chinese medicine composition of thrombophlebitis in the present embodiment, comprise the following steps: accurately get each crude drug according to weight, be crushed to 100 order fine powders; By the fine powder after sieving in 105 DEG C of sterilization treatment 30 minutes; Every 100 grams of fine powders add middle sweet 20 grams, make the honeyed pill of every heavy 0.3g, 50 DEG C of dryings.
The usage of honeyed pill and consumption: oral, one day three times, one time 5, within 30 days, be a course for the treatment of.
Embodiment 3
Be used for the treatment of the Chinese medicine composition of thrombophlebitis in the present embodiment, be made up of the crude drug of following weight: Poria 20 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Codonopsis 15 grams, the Radix Astragali 30 grams, Radix Angelicae Sinensis 20 grams, Radix Paeoniae Rubra 20 grams, 15 grams, Semen Persicae, 15 grams, Flos Carthami, Lignum Sappan 15 grams, Ramulus Cinnamomi 20 grams, Flos Lonicerae 20 grams, Rhizoma Corydalis 20 grams, Fructus Toosendan 20 grams.
Be used for the treatment of the preparation method of the Chinese medicine composition of thrombophlebitis in the present embodiment, comprise the following steps: accurately get each crude drug according to weight, after adding the water soaking of 4 times amount, temperature fire decocts, and is concentrated into 400ml and namely obtains oral liquid.
The usage of oral liquid and consumption: oral, one day twice, a 50ml 15 days is a course for the treatment of, one after each meal.
Embodiment 4
Be used for the treatment of the Chinese medicine composition of thrombophlebitis in the present embodiment, be made up of the crude drug of following weight: Poria 15 grams, the Rhizoma Atractylodis Macrocephalae 12 grams, Radix Codonopsis 10 grams, the Radix Astragali 25 grams, Radix Angelicae Sinensis 18 grams, Radix Paeoniae Rubra 15 grams, 10 grams, Semen Persicae, 10 grams, Flos Carthami, Lignum Sappan 10 grams, Ramulus Cinnamomi 15 grams, Flos Lonicerae 18 grams, Rhizoma Corydalis 15 grams, Fructus Toosendan 12 grams.
Be used for the treatment of the preparation method of the Chinese medicine composition of thrombophlebitis in the present embodiment, comprise the following steps: accurately get each crude drug according to weight, be crushed to 120 order fine powders; By the fine powder after sieving in 100 DEG C of sterilization treatment 30 minutes; Every 100 grams of fine powders add middle sweet 15 grams, make the honeyed pill of every heavy 0.3g, 50 DEG C of dryings.
The usage of honeyed pill and consumption: oral, one day three times, one time 5, within 30 days, be a course for the treatment of.
Embodiment 5
Be used for the treatment of the Chinese medicine composition of thrombophlebitis in the present embodiment, be made up of the crude drug of following weight: Poria 20 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Radix Codonopsis 15 grams, the Radix Astragali 20 grams, Radix Angelicae Sinensis 20 grams, Radix Paeoniae Rubra 10 grams, 15 grams, Semen Persicae, 5 grams, Flos Carthami, Lignum Sappan 15 grams, Ramulus Cinnamomi 10 grams, Flos Lonicerae 20 grams, Rhizoma Corydalis 10 grams, Fructus Toosendan 20 grams.
Be used for the treatment of the preparation method of the Chinese medicine composition of thrombophlebitis in the present embodiment, comprise the following steps: accurately get each crude drug according to weight, after adding the water soaking of 3 times amount, temperature fire decocts, and is concentrated into 300ml and namely obtains oral liquid.
The usage of oral liquid and consumption: oral, one day twice, a 50ml 15 days is a course for the treatment of, one after each meal.
Test example
1, clinical trial
(1) physical data
Choose 120 routine varicose veins of the lower extremity and merge thrombophlebitis patient, with type 2 diabetes mellitus, diagnose clearly and recurrent exerbation, be divided into treatment group and matched group according to randomly assigne, often organize 30 examples.Patient is no significant difference (P > 0.05) in sex, age, severity extent etc., has comparability.
(2) Therapeutic Method
Matched group: at treatment underlying diseases simultaneously, conventional antiinflammatory, changes clothes wound, magnesium sulfate external application;
Treatment group 1: add on treatment of control group basis with the embodiment of the present invention 4 prepare honeyed pill, one day three times, one time 5;
Treatment group 2: add the oral liquid prepared by the embodiment of the present invention 1 on treatment of control group basis, one day twice, a 50ml, one after each meal;
Treatment group 3: add the oral liquid prepared by the embodiment of the present invention 5 on treatment of control group basis, one day twice, a 50ml, one after each meal.
The course for the treatment of of matched group and treatment group is 30 days.Two groups of patients are respectively at treating front and treatment venous blood collection on an empty stomach in latter 30 day early morning, and mensuration hemorheology index, therapeutic outcome refers to following table 1.
(3) curative effect determinate standard
Recovery from illness: Varicose veins superficial vein disappears substantially, lower limb not swelling, Chronic leg ulcer heals;
Effective: Varicose veins superficial vein is calm, lower limb not swelling, Chronic leg ulcer healing area > 3/4, the red work of granulation, without secretions;
Take a turn for the better: Varicose veins vein is calm, lower limb mild swelling, Chronic leg ulcer healing area > 1/2, the redder work of granulation, can have a small amount of secretions;
Effective: Varicose veins superficial vein is calm, lower limb mild swelling, Chronic leg ulcer healing area > 1/4;
Invalid: Varicose veins superficial vein is obvious, lower extremity swelling and distension, Chronic leg ulcer healing area < 1/4 even expands.
(4) therapeutic outcome
Table 1 Chinese medicine composition is to the therapeutic effect of thrombophlebitis
(5) conclusion
Treat after 30 days, the total effective rate for the treatment of group all more than 85%, higher than 71% of matched group; Meanwhile, after treatment group treatment, comparatively matched group is obvious for each hemorheology index decline degree, shows that Chinese medicine composition of the present invention has good therapeutical effect to thrombophlebitis.
During taking Chinese medicine all there is not the untoward reaction such as hepatic and renal function injure in patient, shows that Chinese medicine composition of the present invention has good safety.
2, model case
Case 1:
Mr. Liu, 41 years old, suffers from the varicosis more than ten years, hardens in local; cannot normal activity, through making a definite diagnosis patient for overworked, the varicosis caused of suffering from cold for a long time, cause superficial thrombophlebitis because of wound afterwards; it is rubescent that patient carrys out surrounding skin when institute goes to a doctor, and heating, has lump, touches a tender spot.At the acutely inflamed honeyed pill taken the embodiment of the present invention 4 and prepare that application antibiotic therapy trauma infection contamination causes simultaneously, take the transference cure of patient's swelling and pain after 30 days, the position of hardening is deliquescing gradually also, takes after 60 days movable normal.
Case 2:
Mrs Liu, 58 years old, continues irregular heating for many years, is up to 39 DEG C.Nearly two wheat harvesting periods carry out right lower extremity and swell and ache, can not walk, left lower extremity is from thigh root to the general swelling of foot, and skin is slightly in aubergine, temperature is lower slightly, without pitting edema, great saphenous vein slightly expansion and hardening, all the other ramus superficialis veins have no expansion, femoribus internus tenderness is obvious, at the antibiotic honeyed pill taken the embodiment of the present invention 1 and prepare of application simultaneously, take the transference cure of patient's swelling and pain after 30 days, activity is compared with normal also.

Claims (6)

1. be used for the treatment of a Chinese medicine composition for thrombophlebitis, it is characterized in that: be made up of the crude drug of following parts by weight: Poria 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Radix Codonopsis 5 ~ 15 parts, the Radix Astragali 20 ~ 30 parts, Radix Angelicae Sinensis 15 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, 5 ~ 15 parts, Semen Persicae, 5 ~ 15 parts, Flos Carthami, Lignum Sappan 5 ~ 15 parts, Ramulus Cinnamomi 10 ~ 20 parts, Flos Lonicerae 15 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Fructus Toosendan 10 ~ 20 parts.
2. the Chinese medicine composition being used for the treatment of thrombophlebitis according to claim 1, is characterized in that: be made up of the crude drug of following parts by weight: Poria 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Codonopsis 10 parts, the Radix Astragali 25 parts, Radix Angelicae Sinensis 18 parts, Radix Paeoniae Rubra 15 parts, 10 parts, Semen Persicae, 10 parts, Flos Carthami, Lignum Sappan 10 parts, Ramulus Cinnamomi 15 parts, Flos Lonicerae 18 parts, Rhizoma Corydalis 15 parts, Fructus Toosendan 12 parts.
3. one kind is used for the treatment of the preparation method of the Chinese medicine composition of thrombophlebitis as claimed in claim 1 or 2, it is characterized in that: comprise the following steps: accurately get each crude drug according to parts by weight, add the water soaking of 3 ~ 5 times amount, concentrate after temperature fire decocts and obtain oral liquid.
4. be used for the treatment of a preparation method for the Chinese medicine composition of thrombophlebitis as claimed in claim 1 or 2, it is characterized in that: comprise the following steps: accurately get each crude drug according to parts by weight, pulverize, sieve after fine powder; Get fine powder and carry out sterilization treatment; Honey in adding in the fine powder of sterilizing, after heating mixing, refine obtains honeyed pill.
5. the preparation method being used for the treatment of the Chinese medicine composition of thrombophlebitis according to claim 4, is characterized in that: described sterilising conditions is: sterilizing 25 ~ 35 minutes at 95 ~ 110 DEG C.
6. the preparation method being used for the treatment of the Chinese medicine composition of thrombophlebitis according to claim 4, is characterized in that: the addition of described middle honey is 15 ~ 20% of fine powder quality.
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CN104721293A (en) * 2015-02-15 2015-06-24 路泽华 Chinese medicinal preparation used for treating superficial phlebitis
CN105596814A (en) * 2015-11-16 2016-05-25 孙绪连 Traditional Chinese medicine smoked lotion for treating thrombophlebitis
RU2791373C1 (en) * 2022-05-04 2023-03-07 Частное учреждение образовательная организация высшего образования "Медицинский университет "Реавиз" Method for treatment and prevention of recurrent venous thrombosis after the novel coronavirus infection

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104721293A (en) * 2015-02-15 2015-06-24 路泽华 Chinese medicinal preparation used for treating superficial phlebitis
CN104721293B (en) * 2015-02-15 2017-08-15 路泽华 A kind of Chinese medicine preparation for treating shallow phlebitis
CN105596814A (en) * 2015-11-16 2016-05-25 孙绪连 Traditional Chinese medicine smoked lotion for treating thrombophlebitis
RU2791373C1 (en) * 2022-05-04 2023-03-07 Частное учреждение образовательная организация высшего образования "Медицинский университет "Реавиз" Method for treatment and prevention of recurrent venous thrombosis after the novel coronavirus infection

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