CN106511688A - Traditional Chinese medicine composition for treating cesarean scar pregnancy and placenta accrete, and preparation method and administering method thereof - Google Patents
Traditional Chinese medicine composition for treating cesarean scar pregnancy and placenta accrete, and preparation method and administering method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating cesarean scar pregnancy and placenta accrete, and a preparation method and administering method thereof; the traditional Chinese medicine composition is prepared from, by weight, 4-14 parts of Flos Carthami, 10-20 parts of Radix Angelicae Sinensis, 4-14 parts of Semen Persicae, 7-17 parts of Spina Gleditsiae, 5-15 parts of Radix Trichosanthis, 5-15 parts of Radix Arnebiae seu Lithospermi, 5-15 parts of Pollen Typhae, 1-11 parts of Hirudo, 15-25 parts of Radix Astragali, 7-17 parts of Rhizoma Corydalis, 5-15 parts of Caulis Lonicerae, 5-15 parts of Herba Hedyotidis Diffusae, 7-17 parts of Rhizoma Cyperi, 1-11 parts of Spica Prunellae, and 1-6 parts of Radix Glycyrrhizae. The medicinal materials in the traditional Chinese medicine composition are synergic such that death of trophoblastic cells is induced, fetal adsorption is promoted and accelerated, and adverse effect from medicine is relieved.
Description
Technical field
The invention belongs to technical field of Chinese medicine, and in particular to a kind of for cesaren scars position gestation and Placenta acrreta
Chinese medicine and preparation method thereof.
Background technology
Cesarean scar pregnancy (CSP) refers to that cytula plants the ectopic pregnancy at the cicatrix of Celiotomy Wean uterus, pregnant early stage
There is bleeding or even uterine rupture, if pregnant blastular continues development and grows to isthmus and uterine cavity, it will generation placenta previa,
Placenta acrreta and a series of associated Medium and late pregnancies and maternity outcome, Placenta acrreta belong to Chinese medicine " placenta retention "
" lump in the abdomen " " blood disorder " category, is easily caused placental separation face massive hemorrhage, infection, uterine rupture etc., serious threat female patient
Life and health.
CSP and Placenta acrreta are one of caesarean delivered long term complication, as cesarean delivery rate constantly rises in recent years, its
Raw rate also more and more higher.As most patients are young, Reservations uterus are very wise moves.Blindness of being eager dilatation and curettage of uterine and pincers take the Placenta Hominiss group of implantation
Knit, fatefulue bleeding may be caused.Uterine curettage, medicine are controlled to be included to the Therapeutic Method of CSP and Placenta acrreta clinically at present
[such as methotrexate (MTX), fluorouracil (5 one Fu), mifepristone], uterine curettage, uterine arterial embolization (UAE) are clear afterwards afterwards for treatment
Gong Shu etc..But the unified preferred plan generally acknowledged is there is no at present.Clinically have significantly bad using the Drug therapy of doctor trained in Western medicine
Effect, such as bone marrow depression, hepatic and renal function damage, alopecia etc., especially prolonged application ill effect becomes apparent from, and effectively can not control
More.Even there is small part patient because side effect substantially interrupts treatment.Intervention embolization often spends higher, and receives skill
The conditions such as art equipment are limited.The domestic herb mixture currently used for treatment cicatrix position gestation and Placenta acrreta is few, also has no
There is the report of the Chinese medicine preparation favourable with the same or analogous effect of the present patent application.
The content of the invention
The present invention relates to it is a kind of for cesaren scars position gestation and the Chinese medicine composition of Placenta acrreta, preparation method and
Instructions of taking, with short treating period, curative effect is high, Small side effects, the high advantage of cure rate.
To achieve these goals, the present invention is achieved using following technical proposals：
A kind of component and weight portion be for cesaren scars position gestation and the Chinese medicine composition of Placenta acrreta, Flos Carthami
4-14 parts, Radix Angelicae Sinensis 10-20 parts, Semen Persicae 4-14 parts, Spina Gleditsiae 7-17 parts, Radix Trichosanthis 5-15 parts, Radix Arnebiae (Radix Lithospermi) 5-15 parts, Pollen Typhae 5-15
Part, Hirudo 1-11 parts, Radix Astragali 15-25 parts, Rhizoma Corydalis 7-17 parts, Caulis Lonicerae 5-15 parts, Herba Hedyotidis Diffusae 5-15 parts, Rhizoma Cyperi 7-17
Part, Spica Prunellae 1-11 parts, Radix Glycyrrhizae 1-6 parts.
Compared with prior art, advantages of the present invention and good effect are：The Chinese medicine composition that the present invention is provided, various medicines
Thing collective effect, can make Trophocyte necrosis, promote embryo to absorb.Joint Western medicine is for treatment cesaren scars position gestation
And Placenta acrreta, relative to Western medicine methotrexate and mifepristone is used merely, with short treating period, curative effect is high, and Small side effects are controlled
More the high advantage of rate, can greatly improve the ability for killing that embryo promotes retained placental tissue necrosis to come off.
Specific embodiment
Technical scheme is described in further detail with reference to specific embodiment.The present invention is previously mentioned
Ratio, " part ", if no special labelling, is defined by weight.
The traditional Chinese medical science thinks that cicatrix position gestation and Placenta acrreta belong to Chinese medicine " placenta retention " " lump in the abdomen " " blood disorder " " pregnant abdomen
The category such as bitterly ", this kind of disease embryo and placental villi implantation myometrium it is deeper, melt with muscle fiber and surrounding tissue when serious for
Integrally, drive which and discharge difficulty, need row local or panhysterectomy if necessary.Given this disease feature, clinical treatment should be from " QI invigorating
Embryo is killed in blood-nourishing, blood circulation promoting and blood stasis dispelling, pain relieving, and broken silt disappears, hard masses softening and resolving " angle start with.
The present embodiment is on the basis of above-mentioned theory of Chinese medical science, there is provided a kind of Chinese medicine composition, for treating cesarean section
Scar pregnancy Wang, Placenta acrreta afterwards.The component and weight portion of the Chinese medicine composition be Flos Carthami 4-14 parts, Radix Angelicae Sinensis 10-20 parts, Semen Persicae
4-14 parts, Spina Gleditsiae 7-17 parts, Radix Trichosanthis 5-15 parts, Radix Arnebiae (Radix Lithospermi) 5-15 parts, Pollen Typhae 5-15 parts, Hirudo 1-11 parts, Radix Astragali 15-25
Part, Rhizoma Corydalis 7-17 parts, Caulis Lonicerae 5-15 parts, Herba Hedyotidis Diffusae 5-15 parts, Rhizoma Cyperi 7-17 parts, Spica Prunellae 1-11 parts, Radix Glycyrrhizae 1-6
Part.
A kind of preferred component and weight portion are Flos Carthami 9-14 parts, Radix Angelicae Sinensis 15-20 parts, Semen Persicae 9-14 parts, Spina Gleditsiae 12-17
Part, Radix Trichosanthis 10-15 parts, Radix Arnebiae (Radix Lithospermi) 10-15 parts, Pollen Typhae 10-15 parts, Hirudo 6-11 parts, Radix Astragali 20-25 parts, Rhizoma Corydalis 12-17
Part, Caulis Lonicerae 10-15 parts, Herba Hedyotidis Diffusae 10-15 parts, Rhizoma Cyperi 12-17 parts, Spica Prunellae 6-11 parts, Radix Glycyrrhizae 3-6 parts.
Another kind of preferred component and weight portion are Flos Carthami 4-9 parts, Radix Angelicae Sinensis 10-15 parts, Semen Persicae 4-9 parts, Spina Gleditsiae 7-12
Part, Radix Trichosanthis 5-10 parts, Radix Arnebiae (Radix Lithospermi) 5-10 parts, Pollen Typhae 5-10 parts, Hirudo 1-6 parts, Radix Astragali 15-20 parts, Rhizoma Corydalis 7-12 parts, Radix Ophiopogoniss
Rattan 5-10 parts, Herba Hedyotidis Diffusae 5-10 parts, Rhizoma Cyperi 7-12 parts, Spica Prunellae 1-6 parts, Radix Glycyrrhizae 1-3 parts.
Further preferred component and weight portion are 9 parts of Flos Carthami, 15 parts of Radix Angelicae Sinensis, 9 parts of Semen Persicae, 12 parts of Spina Gleditsiae, Radix Trichosanthis
10 parts, 10 parts of Radix Arnebiae (Radix Lithospermi), 10 parts of Pollen Typhae, 6 parts of Hirudo, 20 parts of the Radix Astragali, 12 parts of Rhizoma Corydalis, 10 parts of Caulis Lonicerae, 10 parts of Herba Hedyotidis Diffusae,
12 parts of Rhizoma Cyperi, 6 parts of Spica Prunellae, 3 parts of Radix Glycyrrhizae.
In the present embodiment Chinese medicine composition, Chinese medicine used is with Flos Carthami, Radix Angelicae Sinensis, Semen Persicae as principal agent, with preferable blood circulation promoting and blood stasis dispelling
Effect；Spina Gleditsiae, Radix Trichosanthis, Radix Arnebiae (Radix Lithospermi), Pollen Typhae, Hirudo etc. be ministerial drug, with removing blood stasis, promote the production of body fluid evacuation of pus the effect of；The Radix Astragali, prolong
Rhizoma Corydalis, Caulis Lonicerae, Herba Hedyotidis Diffusae, Rhizoma Cyperi, Spica Prunellae are adjuvant drug, and the effect of with air making-up and spleen enlivening, mass dissipating and swelling eliminating, Radix Glycyrrhizae reconciles
All medicines, said medicine collective effect can make Trophocyte and placenta tissue necrosis, promote embryo to absorb and tissue loss.Separately
Outward, in formula, the antibacterial of Radix Glycyrrhizae and Caulis Lonicerae, antiinflammatory action are strong, and the toxic and side effects brought to Western medicine can play similar glucal
The Detoxication of acid, the untoward reaction occurred during being effectively reduced western medicine.The Radix Astragali in formula has stronger increasing
The function of strong immunity of organisms.The blood circulation promoting and blood stasis dispelling such as Semen Persicae, Flos Carthami, Pollen Typhae, Herba Hedyotidis Diffusae in formula, hard masses softening and resolving medicine kind
Class is more, has stronger advantage in terms of dead embryo absorption is promoted.The present embodiment with can methotrexate collaboration make
With under, greatly improve and kill embryo ability.
The dosage form of the Chinese medicine composition can be mixture, capsule, granule or oral liquid.
The present embodiment additionally provides the preparation method of above-mentioned Chinese medicine composition：
1st, when the Chinese medicine composition dosage form be herb mixture when, its preparation method be take formula ratio the Radix Astragali, when
Return, Rhizoma Cyperi, Rhizoma Corydalis, Spina Gleditsiae, Radix Trichosanthis, Radix Arnebiae (Radix Lithospermi), Pollen Typhae, Caulis Lonicerae, Herba Hedyotidis Diffusae, Semen Persicae, Flos Carthami, Hirudo, summer it is withered
Grass and Radix Glycyrrhizae are placed in Chinese medicament extracting device, plus clean water retting 1.5-2.5h, and amount of water is the 6-8 of Chinese medicine composition gross mass
Times, heating decocts 1-2h, leaches medicinal liquid, and medicinal residues add water heating and decoct 0.5-1.5h, and amount of water halves, and merges medicinal liquid twice quiet
12h is put, the 15-20% of supernatant concentration to total amount of water is taken, bottled, every bottle of 125mL of loading amount is carried out, is sealed, 115 DEG C of condition
Lower sterilizing 40min, labels and obtains final product.
During above-mentioned herb mixture preparation method, can effectively extract used using preliminary impurity removal process and process for refining
Effective ingredient in drug component, and other active components for wherein containing are expected the work of the performance Synergistic treatment after compatibility
With playing a significantly greater role to improving drug effect, and mitigate toxic and side effects to a certain extent.
2nd, when the dosage form of the Chinese medicine composition is capsule, its preparation method is：
Step 1) each component in the medicine is ground into the powder of 20-30 mesh, stir in being put into blender in proportion
Mixing is mixed, 2-3h is added water to cook, amount of water is 2-4 times of Chinese medicine composition gross mass；Decoction liquor is filtered, and is obtained first and is filtered
Liquid；Add water in filtering residue, amount of water is 2-4 times of Chinese medicine composition gross mass, decoct 1-2h again, decoction liquor is filtered, and is obtained
Second filtrate；First filtrate and the mixing of the second filtrate are obtained into mixed liquor, concentration removes part moisture content, concentrated
Liquid, the volume of concentrated solution are the 1/4-1/5 of mixed liquor before concentration；
Step 2) in concentrated solution add volumetric concentration be 95% ethanol to alcohol content reach percent by volume 80% with
On, 24h is stood at 4 DEG C, filter precipitation, reclaim ethanol, concentration is dried, obtains dry cream, be put into super micron mill and crushed,
The ultra-micro powder of 200-300 mesh is obtained, loads No. 2 capsule for medicine, as Chinese medicine capsules.
During above-mentioned capsule preparation method thereof, the technique for extracting medical material effective ingredient is current using decoction and alcohol sedimentation technique-i.e.
Think optimum solvent and extracting method, the medical material effective ingredient of compositionss can be effectively extracted in the screening of Jing orthogonal experiments.
The present embodiment additionally provides the instructions of taking of above-mentioned Chinese medicine composition：Using the complex treatment measure of the combination of Chinese and Western medicine
And sequential therapy, drug effect is on the one hand improved, on the other hand mitigates side effect.Methotrexate 50mg/ is adopted after specially making a definite diagnosis first
m2Intramuscular injection for treating, once a day；Mifepristone piece 50mg/ time is given simultaneously, (medicine) being taken before meal is used, often minor tick 12h.It is continuous to take
With 3d, if after 1 week, blood HCG content declines, and the range of decrease<15%, same dose methotrexate can be given again injects 1 time.
Herb mixture or capsule oral medication are given in 4d on this basis, according to herb mixture, each 125mL, one day two
It is secondary to take, totally 14 days；According to capsule 3 every time, a day three times, totally 14 days.Patient vitals are kept a close eye in therapeutic process
Sign situation of change.
The Chinese medicine composition of the present embodiment combines Western medicine for cesaren scars position gestation and Placenta acrreta is treated, relatively
In Western medicine methotrexate and mifepristone is used merely, with short treating period, curative effect is high, Small side effects, the high advantage of cure rate.
In formula, the pharmacology of each component is as follows：
The Radix Astragali：The Radix Astragali is the dry root of leguminous plant Radix Astagali or Radix Astragali.It is warm in nature, sweet in the mouth.Energy invigorating QI to consolidate the body surface resistance, profit
Urine poison holding, evacuation of pus, expelling pus and promoting granulation.For treatment deficiency of vital energy weak, anorexia and loose stool, sinking of QI of middle-JIAO, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency is certainly
Antiperspirant, deficiency of vital energy edema, ulcer is difficult to burst, bursts for a long time and does not holds back, blood deficiency and yellow complexion, Heat Diabetes；Chronic nephritis proteinuria, diabetes.Modern times grind
Study carefully and show that the Radix Astragali contains：1. triterpene saponin such as Radix Astragali saponin I-VIII, acetyl Radix Astragali saponin I, different Radix Astragali saponin I, soybean soapstock
Glycosides I, Cycloastragenol, lupeol etc..2. flavonoid such as formoononetin, calycosin, kumatakenin, calycosin -7-
O- β-D-Glucose glycosides etc..3. polysaccharide such as astragalus polysaccharidess I, II, III (astraglalan I, II, III) etc..The Radix Astragali has
Following pharmacological action：1. the Radix Astragali and its polysaccharide, saponin component have extensive effect to immune system, with immunostimulant, exempt from
Based on epidemic disease is adjusted.2. the Radix Astragali has defying age, antioxidation, adjusts Metabolism of nucleic acids and proteins, adjusts cyclic nucleotide system etc. and makees
With.3. the Radix Astragali have positive inotropic, blood pressure lowering, expansion of blood vessels, promote microcirculation, resist myocardial ischemia, arrhythmia, protection the heart
The effects such as flesh, suppression platelet aggregation, promotion hemopoietic function.In addition with liver protection, antiulcer, diuresis, antiviral, blood sugar lowering,
Antiinflammatory, calmness, analgesia etc. are acted on.
Radix Angelicae Sinensis：When the dry root for being classified as umbelliferae angelica.It is warm in nature, it is sweet in the mouth, pungent.Energy replenishing and activating blood, menstruction regulating and pain relieving, profit
Intestinal relieving constipation.For blood deficiency and yellow complexion, menoxenia, amenorrhea dysmenorrhea, dizziness palpitaition, asthenia cold abdominalgia, dry constipation of intestines, ulcer sores are fallen
Beat and damage, rheumatic arthralgia.Modern study shows that Radix Angelicae Sinensis contain：1. volatile oil main component is phthalide analog compound, such as cyclobutenyl
Phthalide, neocnidilide, n butylphthalide, ligustilide, new angelica lactone etc..2. phenolic acids such as ferulic acid etc..3. many
The saccharide such as acidic polysaccharose with anticomplementary activity, by D- galactose, L-arabinose, D- xyloses, glucuronic acid, galactose
Aldehydic acid etc. is constituted, in addition also X-C-3- containing Radix Angelicae Sinensis polysaccharide II, X-C-3- IV etc..Additionally contain xanthotoxin, isopimpinellin, urine
Pyrimidine etc..The Radix Astragali has following pharmacological action：1. the effect Radix Angelicae Sinensis in pair uterus suppress containing two kinds of compositions that are excited and suppressing uterus
Composition is mainly volatile oil, and excited composition is the nonvolatile matter of water solublity or alcohol-soluble.Ligustilide is to unpregnancy or early pregnancy
Rabbit isolated uterine has obvious inhibiting effect, has antagonism to the uteri excitation that acetylcholine, prostaglandin etc. cause, and part is right
The uterine contraction reaction that antiadrenergic drug causes.2. pair cardiovascular effect Radix Angelicae Sinensis can reduce irritability, extend extrasomatic rabbit heart not
Ying Qi, has antagonism to the arrhythmia that acetylcholine, epinephrine cause.Radix Angelicae Sinensis can expand isolated guinea pig coronary, increase
Blood flow, and the peripheral circulation of vasculitiss patient can be improved.Radix Angelicae Sinensis can substantially suppress the platelet activation of antigen induced and have
Obvious anti-thrombosis function.Radix Angelicae Sinensis polysaccharide can increase peripheral red blood cells, leukocyte, hemoglobin and bone marrow nucleated cell
Number.3. enhancing human body immunity function Radix Angelicae Sinensis and Radix Angelicae Sinensis polysaccharide can be obviously promoted mice spleen lymphocytes proliferation, have with ConA, LPS
Synergism.Act in addition with antitumor, liver protection, antioxidation, antiallergic action etc..
Rhizoma Cyperi：Dry rhizome of the Rhizoma Cyperi for sedge dried tuber.Mild-natured, acrid in the mouth is slight bitter, sweet.Energy promoting QI circulation for relieving depression, regulating menstruation
Pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, chest gastral cavity ruffian, cold hernia stomachache, distending pain of the breast, menstruation is not
Adjust, amenorrhea dysmenorrhea.Modern study shows that Rhizoma Cyperi, containing volatile oil about 1%, contains various terpene compounds, mainly has Rhizoma Cyperi in oil
Alkene, α-cyperone, β-cyperone, β-terpenes, to P-cymene, patchoulenone, cyperol, isocyperol, cyperolone etc..
Rhizoma Cyperi reduces can the isolated uterine asystole of the animals such as Cavia porcelluss, rabbit, cat or dog, tension force, and has protection to bronchospasm
Effect；Rhizoma Cyperi volatile oil has estrogen -like effectss, and the effect of wherein cyperene is stronger.Additionally, Rhizoma Cyperi still has antipyretic, analgesia, resists
Inflammation, CNS inhibition, hepatic cholagogic etc. are acted on.
Rhizoma Corydalis：Dry tuber of the Rhizoma Corydalis for papaveraceae plant corydalis.It is warm in nature, acrid in the mouth, hardship.Can invigorate blood circulation, promoting the circulation of QI, only
Bitterly.For chest side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, treating swelling and pain by traumatic injury.Modern study shows Rhizoma Corydalis containing alkaloid about
0.5%, mainly there are Corydaline (d- corydalines), tetrahydropalmatine (dl- Tetrahydropalmatines), Rhizoma Corydalis C prime (former opium
Alkali), Rhizoma Corydalis D prime (l- Tetrahydrocoptisines), l- tetrahydrocolumbamines, d- corybulbines, coptisine, d- boldine dimethyl ethers,
Columbamine etc..Rhizoma Corydalis have following pharmacological action：1. the effect Rhizoma Corydalis total alkaloids of Central nervous system are to reality
Animal is tested with stronger analgesic activity, wherein tetrahydropalmatine effect is most strong, and A prime is taken second place.Rhizoma Corydalis and tetrahydropalmatine pair
Laboratory animal has calmness, syngignoscism.2. the effect Rhizoma Corydalis of pair cardiovascular system can increase the coronary flow of extrasomatic rabbit heart, can
Increase cat heart rate, blood pressure drops, coronary flow.Tetrahydropalmatine has antiarrhythmic effect.3. anti-ulcer effect
Dehydrogenation Corydaline has obvious protective function to Experimental Gastric Ucler.4. the effect tetrahydropalmatine of Endocrine system can be made
For Thalamus, promote rat hypophysis secretion thyroliberin；Increase can thyroid weight, and female can be made little
The Mus oestrous cycle substantially suppresses.
Spina Gleditsiae：Spina Gleditsiae is dried Spina jujubae for leguminous plant Fructus Gleditsia.It is warm in nature, acrid in the mouth.With detumescence poison holding, evacuation of pus,
The effect of parasite killing.Be usually used in carbuncle from the beginning of or difficulty in discharging of pus；External treatment scabies leprosy.《Collected statements on the herbal foundation》Fructus Gleditsia acupuncture, wind-dispelling of drawing out pus by applying a plaster to the affected part.It is all
The non-winner of carbuncle, can draw to dissipate, by broken person, can draw to lift one's head, the person that burst can draw with row pus.It is the in infectionss poison
One wants agent.Modern study shows that Spina Gleditsiae contains the compositions such as flavonoid glycoside, phenols, aminoacid, with antitumaous effect.
Radix Trichosanthis：The root section to wither uses it, has the name of powder, real without powder.Radix Trichosanthis are the root of cucurbitaceous plant Chinese juniper beach wormwood, are
A kind of Chinese medicine, is clearing away heat-fire class medicine, and its concrete effect is clearing away heat-fire, and promoting the production of body fluid to quench thirst, evacuation of pus detumescence control carbuncle and ulcer removing toxic substances.
Cure mainly：Control that calentura is thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.Modern study shows that there is Radix Trichosanthis anti-hydatidiform mole to live
Property, with induced labor, immunosuppressant and antitumor action, also obvious immunoregulation effect, immunocompetence can be strengthened, with aobvious
The antitumor and cytotoxic activity of work.Radix Arnebiae (Radix Lithospermi)：Nature and flavor：Hardship, trembles with fear.Energy removing heat from blood, promoting blood circulation, heat clearing away, removing toxic substances.Warm macule is controlled, it is damp and hot
Jaundice, purpura are told, are defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer etc..Malignant boil, tinea can also be controlled；Mend
The heart, soothing liver-QI, dissipating blood stasis.Modern study shows that its pharmacological action also has following aspect：1. contraceptive efficacy：Radix Arnebiae (Radix Lithospermi) has anti-hypophysis rush property
Glandular hormone and anti-fine hair promote the effect of gonadal hormone.2. antibacterial, antiinflammatory action：Radix Arnebiae (Radix Lithospermi) has inhibitory action to capital section 68-1 viruses, right
Staphylococcus aureuses, Bacterium prodigiosum can also suppress.The tincture of Radix Arnebiae (Radix Lithospermi) also has inhibitory action to pyogenic baeceria, escherichia coli.3. resist swollen
Tumor is acted on：It is reported that, Radix Arnebiae (Radix Lithospermi) has certain curative effect to chorionic epithelioma and malignant mole.
Pollen Typhae：Pollen Typhae is the dry pollen of Typhaceae plant Typha angustifolia Herba Typhae typha orientalises or congener.It is mild-natured, sweet in the mouth.
Can stop blooding, blood stasis dispelling is treating stranguria.For spitting blood, spitting of blood, epistaxis, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, chest and abdomen shouting pain, tumbling and swelling,
Blood strangury and dry pain.Modern study shows that Pollen Typhae contains naringenin, isorhamnetin, Quercetin, isorhamnetin -3-O- (2G- α-L- pyrans Mus
Lee's glycosyl)-rutinoside (i.e. typhaneoside), Quercetin -3-O- α-L- rhamnopyranosyls (1-2)-[α-L- rhamnopyranoses
Base (1-6)] flavones ingredient such as-β-D- pyranglucoside, still containing Palmic acid, stearic acid, Ara, vanillic acid etc.
Acrylic component, with increase coronary flow, improves Myocardial Microcirculation, improves cardiac muscle and toleration, reduction blood fat of the brain to anoxia
Act on atherosclerosiss, excited smooth muscle, coagulant blood, antiinflammatory etc. is prevented and treated.
Caulis Lonicerae：Caulis Lonicerae is dried stem branch for caprifoliaceae plant Radix Ophiopogoniss.It is cold in nature, sweet in the mouth.Energy heat-clearing and toxic substances removing, dispelling wind lead to
Network.For warm disease heating, toxic-heat and blood stasis, carbuncle swells sore, beriberoid pyretic arthralgia, redness and swelling of joints burning pain.Modern study shows that Caulis Lonicerae contains
There are the compositions such as lonicerin, luteolin, chlorogenic acid, the effect with antibacterial, antiinflammatory.
Herba Hedyotidis Diffusae：Herba Hedyotidis Diffusae is dried herb for Maguireothamnus speciosus Herba Hedyotidis Diffusae.Cold nature, mildly bitter flavor,
It is sweet.Energy heat-clearing and toxic substances removing, carbuncle that disappears dissipating bind, inducing diuresis to remove edema.For laryngopharynx swelling and pain, dyspnea and cough due to lung-heat, puckery pain of heat gonorrhea, jaundice due to damp-heat, poisonous snake
Bite, the hot carbuncle of sore swells.Modern study shows that Herba Hedyotidis Diffusae contains asperuloside, asperuloside acid, removes acetate asperuloside
Acid, all composition such as square rafter thuja acid, Herba Paederiae time glycosides, ursolic acid, cupreol, stigmasterol, with antitumor action, anti-inflammation
Effect.
Semen Persicae：Semen Persicae is rosaceous plant Fructus Persicae or the dry mature seed of Prunus davidiana.It is mild-natured, it is bitter in the mouth, sweet.Dispel with promoting blood circulation
The stasis of blood, loosening bowel to relieve constipation, effect of relieving cough and asthma.For amenorrhea dysmenorrhea, abdominal mass mass in the abdomen, lung abscess acute appendicitis, injury from falling down, dry constipation of intestines,
Cough and asthma.Modern study shows that Semen Persicae contains the compositions such as amygdaloside, citrostadienol, Virginia prune glucoside, cupreol, and rich
Containing unsaturated fatty acids such as Oleic acid, linoleic acids, with the effect of blood stasis dispelling blood, antiinflammatory action, anti-allergic effects, antitussive effect etc..
Flos Carthami：Flos Carthami is spent for being dried for feverfew Flos Carthami.It is warm in nature, acrid in the mouth.Energy promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For the moon
Jing is uncomfortable, dysmenorrhea, injury from falling down, lochia, abdominal mass mass in the abdomen, sore swell and ache curative.Modern study shows that Flos Carthami contains：1. flavonoid
Including flavonols and chalcone.Flavonols have nimbecetin (i.e. kaempferol), Quercetin, rutin, 6- hydroxyl nimbecetins, 6-
Hydroxyl Kampferol-3-O-glucoside etc.；Chalcone mainly has S-A Hydroxysafflor yellow A, saffloside, carthamone, Flos Carthami
Safflor yellow A etc..2. fatty acid such as Palmic acid, myristic acid, lauric acid, Oleic acid, linoleic acid etc..Additionally, also containing carbene class,
The compositions such as volatile oil.Flos Carthami pharmacological action includes：1. pair cardiovascular effect is decocted to Bufo siccuss isolated heart and rabbit heart in vivo
Agent low dose can strengthen heart contracting power, and heavy dose has inhibitory action.Aqueous extract Flos Carthami injection liquid energy is made in body dog heart arteria coronaria stream
Amount increases, and improves mice hypoxia-bearing capability, increases mice's myocardial nutritional blood flow.Aqueous extract substantially can reduce anesthetized cat,
The blood pressure of dog.Water decoction rat test still has the function of suppressing platelet aggregation and resist inside and outside blood coagulation.2. the effect of pair smooth muscle
Decoct is in excitation to the isolated uterine of mice, Cavia porcelluss, rabbit, cat and Canis familiaris L., makes uterus produce tonicity and Rythmic contractions characteristic,
Pregnant uterus is become apparent from.3. non-specific immunity, humoral immunization of the immunological enhancement Flos Carthami decocting liquid to mice
And cellular immune function has obvious potentiation.Safflower polysaccharide can promote mouse lymphocyte to convert, and increase splenocyte pair
Sheep red blood cell plaque forming cellss' number, the immunosuppressive action with antagonism meticortelone.
Hirudo：Dry body of the Hirudo for Hirudinidae animal whitmania, Folium Salicis Babylonicae Hirudo or Hirudo.It is mild-natured, salty in the mouth, hardship.Energy removing blood stasis,
Removing blood stasis, stimulate the menstrual flow.For abdominal mass mass in the abdomen, blood stasis is through closing, injury from falling down.Modern study shows that Hirudo mainly contains protein, heparin, resists
Thrombin and aminoacid, wherein with glutamic acid, aspartic acid, leucine, lysine and valine content as height.Hirudo pharmacology
Effect includes：1. Rat Experimental thrombosiss are had substantially by antithrombus formation and anticoagulation HV1 g/kg intravenous injections
Inhibitory action.Decaptitate mice thrombus in vivo and rat artery and vein bypass of the Hirudo ethanol extract to collagen protein-epinephrine induction
Thrombosiss significantly inhibit effect, and can improve erythrocyte membrane and platelet membrane fluidity.2. thrombolytic effect is to rabbit vein
Established thrombosis are had dissolution by injection hirudin 1g/kg.So hirudin can not only prevent thrombosiss, Er Qieneng
Thrombus.3. antiplatelet effects hirudin energy enzyme anticoagulant is combined with platelet, promotes thrombin to dissociate with platelet,
Platelet is suppressed to receive the release of stimulated by thrombin and reacting by thrombin induction.4. hemorheological impact Hirudo is extracted
Thing gives animal gavage, reduces can blood viscosity, and erythrocyte electrophoretic time shortens.Hirudo decocting alcohol extract can reduce Ischemia Reperfusion
Apoptosis rate after note, is the effective protection agent of ischemia-reperfusion lung injury.5. effect for reducing blood fat is to bait hyperlipemia man
No matter rabbit gavage Hirudo powder, prevent and treat medication, blood cholesterol and triacylglycerol content can reduced, while making actively
Arteries and veins is light compared with matched group with coronary artery pathological changes, and plaque regression is obvious, it is seen that collagen fiber hyperplasia, and cholesterol crystal is reduced.
Spica Prunellae：Fruit ear is dried for labiate Spica Prunellae.The property of medicine:It is pungent, bitter, tremble with fear.Return liver, gallbladder meridian, clearing away heat-fire,
Mass dissipating and swelling eliminating.For 1. conjunctival congestion and swelling pain, dizziness of having a headache, mesh pearl nyctalgia.This product bitter cold master enters Liver Channel, is apt to removing fire from the liver with improving eyesight.With
Flaming up of liver-fire is controlled, conjunctival congestion and swelling pain can be medicinal with Folium Mori, Flos Chrysanthemi, Semen Cassiae etc..2. scrofula, goiter.This product acrid in the mouth energy eliminating stagnation, it is bitter
It is cold to expel the heat-evil, to control pathogenic fire derived from stagnation of liver-QI, the scrofula of phlegm-fire cohesion.3. acute mastitis swells and ache.This product can heat clearing away go liver-fire, and can eliminating stagnation
Detumescence, can control acute mastitis and swell and ache, often used with Herba Taraxaci together (《Collected statements on the herbal foundation》).Modern pharmacological research thinks Spica Prunellae soap containing triterpene
The organic acid such as the glycoside such as glycosides, rutin, hyperin material and ursolic acid, caffeic acid, free oleanolic acid；Containing winged swallow in spica
Careless element, the anthocyanin of cyanidin, d- Camphoras, d- fenchones etc..This product has blood pressure lowering, antiinflammatory action, to dysentery bacterium, wound
Cold bacillus, vibrio cholera, escherichia coli, Bacillus proteuss, staphylococcuses and Bacillus tuberculosis have certain inhibitory action.
Radix Glycyrrhizae：Radix Glycyrrhizae is dried root and rhizome for glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..It is mild-natured, sweet in the mouth.Energy
Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation,
Cough with copious phlegm, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.Modern study shows that Radix Glycyrrhizae contains：1.
Triterpene saponin mainly have glycyrrhizin, Glycyrrhiza uralensis Fisch. saponin A, B, glycyrrhizin A3, B2, C2, D3, E2, F3, G2, H2,
J2, K2 etc..2. flavonoid mainly has 4',7-Dihydroxyflavanone, liquirtin, isoliquiritin unit, isoliquiritin, Neoliquiritin, strange Radix Glycyrrhizae
Glycosides, formoononetin etc..3. Coumarinses glycycoumarin, glycyol, isoglycyol, glycycoumarin -7- methyl ethers, Radix Glycyrrhizae pyrrole
Mutter coumarin, licocoumarone etc..4. alkaloidss 5,6,7,8- tetrahydrochysenes -4- methylquinolines, 5,6,7,8- tetrahydrochysene -2,4- diformazans
Base quinoline etc..5. polysaccharide Angelica Polysaccharide UA, UB, UC etc..Radix Glycyrrhizae have antivirus action, adrenocortical hormone sample effect,
Antiinflammatory action, adjust body's immunity, antiulcer, liver protection, promote the effect such as pancreatic secretion, Radix Glycyrrhizae is poisoned to multi-medicament,
Metabolite poisoning, bacteriotoxin poisoning, pesticide intoxication and alimentary toxicosis have certain detoxifying effect, and effective ingredient is sweet
Careless glucin.Additionally, Radix Glycyrrhizae also has blood fat reducing, relieving cough and expelling phlegm, antitumor, mutation, antioxidation etc. to act on.
Embodiment 1
A kind of Chinese medicine composition makes the preparation method of herb mixture：Flos Carthami 0.4kg, Radix Angelicae Sinensis 1.0kg, Semen Persicae 0.4kg are taken,
Spina Gleditsiae 0.7kg, Radix Trichosanthis 0.5kg, Radix Arnebiae (Radix Lithospermi) 0.5kg, Pollen Typhae 0.5kg, Hirudo 0.1kg, Radix Astragali 1.5kg, Rhizoma Corydalis 0.7kg,
Caulis Lonicerae 0.5kg, Herba Hedyotidis Diffusae 0.5kg, Rhizoma Cyperi 0.7kg, Spica Prunellae 0.1kg, Radix Glycyrrhizae 0.1kg, are placed in Chinese medicament extracting device,
Plus clean water 100L dipping 2h, heating decoction 1.5h, medicinal liquid is leached, medicinal residues add water 50L heating and decoct 1h, merge medicinal liquid twice
12h being stood, supernatant concentration being taken to 25L, every bottle of 125mL of loading amount, sealing, sterilize under conditions of 115 DEG C 40min, labels i.e.
.(crude drug content 0.27kg/L)
Embodiment 2
A kind of Chinese medicine composition makes the preparation method of herb mixture：Flos Carthami 0.6kg, Radix Angelicae Sinensis 1.2kg, Semen Persicae 0.6kg are taken,
Spina Gleditsiae 1.0kg, Radix Trichosanthis 0.8kg, Radix Arnebiae (Radix Lithospermi) 0.8kg, Pollen Typhae 0.8kg, Hirudo 0.3kg, Radix Astragali 1.8kg, Rhizoma Corydalis 1.0kg,
Caulis Lonicerae 0.8kg, Herba Hedyotidis Diffusae 0.8kg, Rhizoma Cyperi 1.0kg, Spica Prunellae 0.3kg, Radix Glycyrrhizae 0.2kg, are placed in Chinese medicament extracting device,
Plus clean water 100L dipping 2h, heating decoction 1.5h, medicinal liquid is leached, medicinal residues add water 50L heating and decoct 1h, merge medicinal liquid twice
12h being stood, supernatant concentration being taken to 25L, every bottle of 125mL of loading amount, sealing, sterilize under conditions of 115 DEG C 40min, labels i.e.
.(crude drug content 0.41kg/L)
Embodiment 3
A kind of Chinese medicine composition makes the preparation method of herb mixture：Flos Carthami 0.9kg, Radix Angelicae Sinensis 1.5kg, Semen Persicae 0.9kg are taken,
Spina Gleditsiae 1.2kg, Radix Trichosanthis 1.0kg, Radix Arnebiae (Radix Lithospermi) 1.0kg, Pollen Typhae 1.0kg, Hirudo 0.6kg, Radix Astragali 2.0kg, Rhizoma Corydalis 1.2kg,
Caulis Lonicerae 1.0kg, Herba Hedyotidis Diffusae 1.0kg, Rhizoma Cyperi 1.2kg, Spica Prunellae 0.6kg, Radix Glycyrrhizae 0.3kg, are placed in Chinese medicament extracting device,
Plus clean water 100L dipping 2h, heating decoction 1.5h, medicinal liquid is leached, medicinal residues add water 50L heating and decoct 1h, merge medicinal liquid twice
12h being stood, supernatant concentration being taken to 25L, every bottle of 125mL of loading amount, sealing, sterilize under conditions of 115 DEG C 40min, labels i.e.
.(crude drug content 0.62kg/L)
Embodiment 4
A kind of Chinese medicine composition makes the preparation method of Chinese medicine capsules：Take Flos Carthami 0.9kg, Radix Angelicae Sinensis 1.5kg, Semen Persicae
0.9kg, Spina Gleditsiae 1.2kg, Radix Trichosanthis 1.0kg, Radix Arnebiae (Radix Lithospermi) 1.0kg, Pollen Typhae 1.0kg, Hirudo 0.6kg, Radix Astragali 2.0kg, Rhizoma Corydalis
1.2kg, Caulis Lonicerae 1.0kg, Herba Hedyotidis Diffusae 1.0kg, Rhizoma Cyperi 1.2kg, Spica Prunellae 0.6kg, Radix Glycyrrhizae 0.3kg, are ground into 20
Purpose powder, is put into stirring mixing in blender, adds the water of 60kg, carry out decocting 3 hours, and decoction liquor is filtered, and obtains first
Filtrate；Filtering residue is added into the water of 30kg, carries out again decocting 2 hours, decoction liquor is filtered, and obtains the second filtrate；By first
Filtrate and the mixing of the second filtrate obtain mixed liquor, and concentration removes part moisture content, obtains concentrated solution, and the volume of concentrated solution is dense
The 1/5 of mixed liquor before contracting；In concentrated solution add volumetric concentration 95% ethanol to alcohol content reach percent by volume 80% with
On, 24 hours are stood at 4 DEG C, filter precipitation, reclaim ethanol, concentration is dried, and obtains dry cream, and being put into super micron mill carries out powder
It is broken, the ultra-micro powder of 200 mesh is obtained, loads No. 2 capsule for medicine, as Chinese medicine capsules.(crude drug content 17.11g/ grain)
Embodiment 5
A kind of Chinese medicine composition makes the preparation method of Chinese medicine capsules：Take Flos Carthami 1.2kg, Radix Angelicae Sinensis 1.8kg, Semen Persicae
1.2kg, Spina Gleditsiae 1.5kg, Radix Trichosanthis 1.2kg, Radix Arnebiae (Radix Lithospermi) 1.2kg, Pollen Typhae 1.2kg, Hirudo 0.8kg, Radix Astragali 2.2kg, Rhizoma Corydalis
1.5kg, Caulis Lonicerae 1.2kg, Herba Hedyotidis Diffusae 1.2kg, Rhizoma Cyperi 1.5kg, Spica Prunellae 0.8kg, Radix Glycyrrhizae 0.5kg, are ground into 20
Purpose powder, is put into stirring mixing in blender, adds the water of 60kg, carry out decocting 3 hours, and decoction liquor is filtered, and obtains first
Filtrate；Filtering residue is added into the water of 30kg, carries out again decocting 2 hours, decoction liquor is filtered, and obtains the second filtrate；By first
Filtrate and the mixing of the second filtrate obtain mixed liquor, and concentration removes part moisture content, obtains concentrated solution, and the volume of concentrated solution is dense
The 1/5 of mixed liquor before contracting；In concentrated solution add volumetric concentration 95% ethanol to alcohol content reach percent by volume 80% with
On, 24 hours are stood at 4 DEG C, filter precipitation, reclaim ethanol, concentration is dried, and obtains dry cream, and being put into super micron mill carries out powder
It is broken, the ultra-micro powder of 200 mesh is obtained, loads No. 2 capsule for medicine, as Chinese medicine capsules.(crude drug content 22.81g/ grain)
Embodiment 6
A kind of Chinese medicine composition makes the preparation method of Chinese medicine capsules：Take Flos Carthami 1.4kg, Radix Angelicae Sinensis 2.0kg, Semen Persicae
1.4kg, Spina Gleditsiae 1.7kg, Radix Trichosanthis 1.5kg, Radix Arnebiae (Radix Lithospermi) 1.5kg, Pollen Typhae 1.5kg, Hirudo 1.1kg, Radix Astragali 2.5kg, Rhizoma Corydalis
1.7kg, Caulis Lonicerae 1.5kg, Herba Hedyotidis Diffusae 1.5kg, Rhizoma Cyperi 1.7kg, Spica Prunellae 1.1kg, Radix Glycyrrhizae 0.6kg, are ground into 20
Purpose powder, is put into stirring mixing in blender, adds the water of 60kg, carry out decocting 3 hours, and decoction liquor is filtered, and obtains first
Filtrate；Filtering residue is added into the water of 30kg, carries out again decocting 2 hours, decoction liquor is filtered, and obtains the second filtrate；By first
Filtrate and the mixing of the second filtrate obtain mixed liquor, and concentration removes part moisture content, obtains concentrated solution, and the volume of concentrated solution is dense
The 1/5 of mixed liquor before contracting；In concentrated solution add volumetric concentration 95% ethanol to alcohol content reach percent by volume 80% with
On, 24 hours are stood at 4 DEG C, filter precipitation, reclaim ethanol, concentration is dried, and obtains dry cream, and being put into super micron mill carries out powder
It is broken, the ultra-micro powder of 200 mesh is obtained, loads No. 2 capsule for medicine, as Chinese medicine capsules.(crude drug content 26.61g/ grain)
1st, acute toxicity testing is carried out respectively to above-described embodiment 3,6.
1.1 medicines prepare
Mixture 250mL prepared by Example 3, puts 70 DEG C of water-baths, is concentrated into 37mL (4.18g/mL containing crude drug)；Treating excess syndrome is applied
Capsule 9 prepared by example 6, content 37mL distillations water dissolution (6.47g/mL containing crude drug).
1.2 medication
Embodiment 3,6 takes kunming mice 20 respectively, and (half and half) body weight 18-20g, male and female is raised 1 week in laboratory animal room
Afterwards, experimental group and blank control group are randomly divided into, acute toxicity testing is carried out using maximum dosage-feeding method, fasting before administration be can't help
Water 12h.
The experimental group of embodiment 3 gives medicine 40mL/kg gavages, and blank control group gives distilled water 40mL/kg gavages,
It is administered every 6h again, fasting 2h before administration.
The experimental group of embodiment 6 gives the medicine 40mL/kg gavages after dissolving, and blank control group gives distilled water 40mL/
Kg gavages, interval 6h are administered again, fasting 2h before administration.
Close observation in 4h after administration, hereafter each gavage of upper and lower noon 1 time daily, Continuous Observation 7d, itemized record.In
The de- necks of 8d put to death experiment mice, dissection, the change of each internal organs of perusal.
1.3 experimental result
In embodiment 3,6 after totally 40 mices administration 7d, health existence, no abnormality seen and toxic reaction, become celestial naked eyes
The performance without exception of each internal organs is observed, and maximum tolerated dose is measured for 229.9g/kg.
2nd, clinical experiment is carried out respectively to above-described embodiment 3,6：
2.1 clinical experimental datas are originated
Selected from special outpatient clinic patient, the follow-up case for listing statistics in is, is randomly divided into treatment group 27, matched group 42
Example.
The harmony of 2.2 data
Matched group is contrasted at the aspects such as age, the course of disease, site of pathological change, disease time, clinical manifestation and treatment group, Jing statistics
There was no significant difference to learn detection, shows that two groups of compositions are balanced, with comparability.
2.3 diagnostic criteria
There is menolipsis history, have irregular colporrhagia, wherein 16 have stomachache, Blood β-HCG (β-HCG)
Value is raised, and Combination echo agglomerate is seen at B ultrasonic acoustic inspection low cesarean section cicatrix, and blood flow enriches.Patient belongs to Jing and surpasses
Sound and nuclear magnetic resonance, NMR make a definite diagnosis cicatrix position gestation or Placenta Hominiss are not given birth to or part is not given birth to, the state of an illness after delivery of baby after induction of labour
It is stable, a small amount of bleeding of vagina.There is Placenta acrreta high risk factor；Postpartum placenta is detained, and free-hand stripping can not find stripping crack, or portion
Divide Placenta Hominiss peel off；Placenta acrreta is pointed out in ultrasound diagnosis；Uterine cavity discharges tissue censorship for downright bad placenta tissue.
2.4 exclusion standard
Patient checks that before medication hepatic and renal function, routine blood test and coagulation function are normal, and uses contraindication without MTX.Row
Except severe cardiac, liver, kidney device dysfunction and drug allergy person；Cannot cooperate or be unwilling partner.
2.5 Therapeutic Method
Treatment group：Receive the treatment of methotrexate Combined with Chinese Herbal, wherein herb mixture prepared by 14 oral embodiments 3, meal
Front half an hour is oral, and 1 bottle every time, 2 times a day；It is within 14 days 1 course for the treatment of, treats 1 course for the treatment of.It is prepared by other 13 oral embodiments 6
Chinese medicine capsules, 3 every time, 3 times a day；It is within 14 days 1 course for the treatment of, treats 1 course for the treatment of.Matched group：Receive methotrexate joint
Mifepristone in treating.
2.6 curative effect judging standard
With reference to patients with clinical manifestations, β-HCG value decline situations, at ultrasonic examination cicatrix, focus is present and blood circumstance.
Cure：Jing after taking the treatment of MTX+ 1 course for the treatment of of this herb mixture, clinical symptoms are wholly absent, and β-HCG are down to
Below 500U/L, row ultrasound guidance uterine curettage, without gestation sac and retained placental tissue at check ultrasound prompting hypomere cicatrix.Art
Afterwards regular follow-up patients serum HCG drop to normally, menstruation recovery.
Postpone to cure：Clinical symptom disappearance or be clearly better Jing after 1 course for the treatment of of above-mentioned treatment, β-HCG be down to 2000U/L with
Under, but check ultrasound prompting lesions position and still have blood flow, need to further take the preparation 1-3 courses for the treatment of, the noresidue of the rear row clearing heat in the pericardium, periodically
Follow-up patients serum β-HCG drop to normally, menstruation recovery.
It is invalid：After the treatment 2-3 courses for the treatment of, without being clearly better, check β-HCG decline not substantially symptom, or ultrasound check prompting disease
Stove position blood flow enriches, and is not suitable for row clearing heat in the pericardium person.
2.7 therapeutic outcomes, as shown in table 1
1 two groups of therapeutic outcomes of table compare
As it can be seen from table 1 the clinical efficacy for the treatment of group is better than matched group, P<0.05.Therefore, the medicine group of the present embodiment
All medicines share in compound, has benefit in making row, has life in change, breaks and does not just hinder, mends and not stagnant heresy, plays removing blood stasis promoting blood circulation altogether, dissipates
The effect of knot, make congestion dispel, fresh blood life, fill the post of and, the involution of uterus, afterbirth from going out, for treating scar pregnancy Wang, Placenta acrreta safety
With it is effective, medicine source is wide, and toxic and side effects are little, effectively shortens treatment time, reduces operability, reduces patient to the full extent
Pain, mitigate patient somatic damage and economy, psychological burden, it is easy to be accepted by patients, be social save medical resources.
Above example is only several in several preferred implementation of the invention, it is noted that be the invention is not restricted to
Above-described embodiment；For the person of ordinary skill of the art, still can be to the technical scheme described in previous embodiment
Modify, or equivalent is carried out to which part technical characteristic；And these modifications or replacement, do not make relevant art side
The essence of case departs from the spirit and scope of claimed technical solution of the invention.
Claims (9)
1. it is a kind of for cesaren scars position gestation and Placenta acrreta Chinese medicine composition, it is characterised in that component and weight
Part it is, Flos Carthami 4-14 parts, Radix Angelicae Sinensis 10-20 parts, Semen Persicae 4-14 parts, Spina Gleditsiae 7-17 parts, Radix Trichosanthis 5-15 parts, Radix Arnebiae (Radix Lithospermi) 5-15 parts,
Pollen Typhae 5-15 parts, Hirudo 1-11 parts, Radix Astragali 15-25 parts, Rhizoma Corydalis 7-17 parts, Caulis Lonicerae 5-15 parts, Herba Hedyotidis Diffusae 5-15 parts,
Rhizoma Cyperi 7-17 parts, Spica Prunellae 1-11 parts, Radix Glycyrrhizae 1-6 parts.
2. Chinese medicine composition according to claim 1, it is characterised in that component and weight portion be, Flos Carthami 9-14 parts, Radix Angelicae Sinensis
15-20 parts, Semen Persicae 9-14 parts, Spina Gleditsiae 12-17 parts, Radix Trichosanthis 10-15 parts, Radix Arnebiae (Radix Lithospermi) 10-15 parts, Pollen Typhae 10-15 parts, Hirudo 6-
11 parts, Radix Astragali 20-25 parts, Rhizoma Corydalis 12-17 parts, Caulis Lonicerae 10-15 parts, Herba Hedyotidis Diffusae 10-15 parts, Rhizoma Cyperi 12-17 parts, the summer
Hay 6-11 parts, Radix Glycyrrhizae 3-6 parts.
3. Chinese medicine composition according to claim 1, it is characterised in that component and weight portion be, Flos Carthami 4-9 parts, Radix Angelicae Sinensis
10-15 parts, Semen Persicae 4-9 parts, Spina Gleditsiae 7-12 parts, Radix Trichosanthis 5-10 parts, Radix Arnebiae (Radix Lithospermi) 5-10 parts, Pollen Typhae 5-10 parts, Hirudo 1-6 parts,
Radix Astragali 15-20 parts, Rhizoma Corydalis 7-12 parts, Caulis Lonicerae 5-10 parts, Herba Hedyotidis Diffusae 5-10 parts, Rhizoma Cyperi 7-12 parts, Spica Prunellae 1-6
Part, Radix Glycyrrhizae 1-3 parts.
4. the Chinese medicine composition according to any one of claim 1-3, it is characterised in that component and weight portion be, Flos Carthami 9
Part, 15 parts of Radix Angelicae Sinensis, 9 parts of Semen Persicae, 12 parts of Spina Gleditsiae, 10 parts of Radix Trichosanthis, 10 parts of Radix Arnebiae (Radix Lithospermi), 10 parts of Pollen Typhae, 6 parts of Hirudo, 20 parts of the Radix Astragali,
12 parts of Rhizoma Corydalis, 10 parts of Caulis Lonicerae, 10 parts of Herba Hedyotidis Diffusae, 12 parts of Rhizoma Cyperi, 6 parts of Spica Prunellae, 3 parts of Radix Glycyrrhizae.
5. it is a kind of for cesaren scars position gestation and Placenta acrreta Chinese medicine composition preparation method, it is characterised in that
Chinese medicine composition described in any one of claim 1-4 is made into herb mixture, method is：Take the Radix Astragali of formula ratio, Radix Angelicae Sinensis, perfume (or spice)
Attached, Rhizoma Corydalis, Spina Gleditsiae, Radix Trichosanthis, Radix Arnebiae (Radix Lithospermi), Pollen Typhae, Caulis Lonicerae, Herba Hedyotidis Diffusae, Semen Persicae, Flos Carthami, Hirudo, Spica Prunellae and sweet
Grass is placed in Chinese medicament extracting device, and add water dipping 1.5-2.5h for the first time, and heating decocts 1-2h, leaches medicinal liquid, and medicinal residues add for second
Water, heating decoct 0.5-1.5h, merge medicinal liquid twice and stand 12h, take supernatant concentration, carry out bottled, every bottle of 125mL of loading amount,
Sealing, sterilize under conditions of 115 DEG C 40min, obtains final product.
6. preparation method according to claim 5, it is characterised in that the first time amount of water is the total matter of Chinese medicine composition
6-8 times of amount；Second amount of water halves；The 15-20% of the supernatant concentration to total amount of water.
7. it is a kind of for cesaren scars position gestation and Placenta acrreta Chinese medicine composition preparation method, it is characterised in that
Chinese medicine composition described in any one of claim 1-4 is made into capsule, method is：
Step 1）Each component in the Chinese medicine composition is respectively crushed into into the powder of 20-30 mesh, blender is put in proportion
Middle stirring mixing, adds water to cook 2-3h, and decoction liquor is filtered, and obtains the first filtrate；Add water in filtering residue, decoct 1-2h again,
Decoction liquor is filtered, and obtains the second filtrate；First filtrate and the mixing of the second filtrate are obtained into mixed liquor, concentration removes part
Moisture content, obtains concentrated solution；
Step 2）In concentrated solution, add ethanol to the alcohol content that volumetric concentration is 95% to reach percent by volume more than 80%, 4 DEG C
Lower standing 24h, filters precipitation, reclaims ethanol, and concentration is dried, obtains dry cream, be put into super micron mill and crushed, obtains
The ultra-micro powder of 200-300 mesh, loads No. 2 capsule for medicine, as Chinese medicine capsules.
8. preparation method according to claim 7, it is characterised in that step 1）In twice amount of water be Chinese medicine composition respectively
2-4 times of thing gross mass；The volume of the concentrated solution is the 1/4-1/5 of mixed liquor before concentration.
9. it is a kind of for cesaren scars position gestation and Placenta acrreta Chinese medicine composition instructions of taking, it is characterised in that
Methotrexate 50mg/m is adopted after making a definite diagnosis first2Intramuscular injection for treating, once a day；Mifepristone piece 50mg/ time, sky are given simultaneously
Abdomen is taken, per 12 h of minor tick；3d is taken continuously, if after 1 week, blood HCG content declines, and the range of decrease<15%, phase is given again
Inject 1 time with dose methotrexate；Herb mixture oral medication described in claim 5 is given in the 4th d on this basis, is fetched water
Decoction, each l agent, 125mL, twice a day；Or capsule 3 described in claim 7 are given, a day three times；Totally 14 days, treatment
During keep a close eye on vital sign patient, stomachache and colporrhagia situation of change.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114848802A (en) * | 2022-05-23 | 2022-08-05 | 黑龙江八一农垦大学 | Bioactive composition for preventing and/or treating retained afterbirth of dairy cow, application thereof, powder and tablet |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110722A (en) * | 2013-02-25 | 2013-05-22 | 青岛大学医学院附属医院 | Traditional Chinese medicine for treating chronic pelvic inflammatory disease and preparation method thereof |
| CN103751727A (en) * | 2014-02-19 | 2014-04-30 | 崔新明 | Pharmaceutical composition for treating extrauterine pregnancy and application thereof |
| CN105079633A (en) * | 2015-09-18 | 2015-11-25 | 山东省立医院 | Traditional Chinese medicine composition capable of activating blood circulation to remove blood stasis and removing cumulation and stasis |
| CN105412661A (en) * | 2015-12-15 | 2016-03-23 | 郭希梅 | Traditional Chinese medicine for treating ectopic pregnancy and preparation method |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110722A (en) * | 2013-02-25 | 2013-05-22 | 青岛大学医学院附属医院 | Traditional Chinese medicine for treating chronic pelvic inflammatory disease and preparation method thereof |
| CN103751727A (en) * | 2014-02-19 | 2014-04-30 | 崔新明 | Pharmaceutical composition for treating extrauterine pregnancy and application thereof |
| CN105079633A (en) * | 2015-09-18 | 2015-11-25 | 山东省立医院 | Traditional Chinese medicine composition capable of activating blood circulation to remove blood stasis and removing cumulation and stasis |
| CN105412661A (en) * | 2015-12-15 | 2016-03-23 | 郭希梅 | Traditional Chinese medicine for treating ectopic pregnancy and preparation method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114848802A (en) * | 2022-05-23 | 2022-08-05 | 黑龙江八一农垦大学 | Bioactive composition for preventing and/or treating retained afterbirth of dairy cow, application thereof, powder and tablet |
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Application publication date: 20170322 |