CN103638188A - Chinese medicine for preventing and treating chronic osteomyelitis and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese medicine for preventing and treating chronic osteomyelitis and a preparation method thereof, and belongs to the field of Chinese medicines. The medicine disclosed by the invention comprises the following effective ingredients of raw materials in parts by weight: 60 parts of dandelion, 60 parts of angelica sinensis, 53 parts of radix paeoniae alba, 52 parts of siam psychotria herb, 48 parts of honeysuckle, 45 parts of astragalus membranaceus, 45 parts of rehmanniae vaporata, 40 parts of parasitic loranthus, 40 parts of liquorice, 35 parts of tuckahoe, 32 parts of hematoxylon, 25 parts of huangcipi (Chinese character), 25 parts of rhizoma drynariae, 24 parts of myrrh, 20 parts of radix angelicae, 18 parts of spina gleditsiae, 14 parts of endothelium corneum gigeriae galli, 13 parts of swimming bladder, 15 parts of cicada slough, 12 parts of cartialgenous, 9 parts of scorpio, 7 parts of cinnamon, 4.5 parts of sting worm and 5 parts of cuttlebone. The Chinese medicine selects the medicinal materials according to the principles of monarch, minister, assistant and guide, and is elaborately prepared, and medicaments in the full formula have the effects of nourishing and purging, treating both symptoms and root causes, promoting and nourishing qi and blood, boosting essence and filling marrow, tonifying spleen and kidney, strengthening body resistance and eliminating evil, and promoting tissue regeneration, and have significant curative effects, so that the spleen and kidney are healthy and vigorous, and qi and blood are smooth. Clinical validation information shows that the Chinese medicine disclosed by the invention also has the effects of resisting and inhibiting bacteria, enhancing the organism immune capacity, improving vascular microcirculation and the like.

Description

A kind of for preventing and treating Chinese medicine of chronic osteomyelitis and preparation method thereof

Affiliated technical field

The present invention relates to Chinese medicine, especially a kind of for preventing and treating Chinese medicine of chronic osteomyelitis and preparation method thereof.

Background technology

Chronic osteomyelitis belongs to motherland's medical science " pyogenic infection of the bone " category, and sickness rate is higher, and modal pathogenic bacterium are staphylococcus aureus.Due to its complicated pathological change, and in staphylococcus aureus, generation and the recall rate of multi-drug resistant bacteria pearl methicillin-resistant staphylococcus aureus (MRSA) constantly rises, and makes chronic osteomyelitis be difficult to treatment.The treatment of modern medicine is mainly to rely on the heavy dose of antibiotic treatment by oral administration of medicines of use in conjunction or local application, coordinates operation wound clearing drain and repairs the measures such as bone is damaged to promote the recovery of disease.But often easily recurrence and touching difficulty heal this disease.The traditional Chinese medical science has accumulated the experience of many preciousnesses to primary disease, some intractable case is fully recovered.By the Chinese medicine research situation to primary disease, inquire into, confirmation application oral medicinal herb has advantages such as adjusting function, the enhancing immunity of whole body internal organs organ, the toxic and side effects of improving nutriture, minimizing bacterial resistance, reduction Western medicine, raising curative effect.Follow motherland's traditional medical theory, in conjunction with clinical practice for many years, by animal experiment system observe the curative effect of Chinese herbal medicine gavage treatment chronic osteomyelitis, thereby further instruct the treatment to chronic osteomyelitis in clinical practice.

The pathogenic factor of chronic osteomyelitis is a lot, sums up and mainly contains four: 1) patient body quality is weak or body is empty after being ill, and residual poison is residual, furthermore damp and hot interior sense, evil poison is altered general muscles and bones, so that stagnation of QI-blood, and meridians impatency is obstructed, strongly fragrant and erosion bone; 2) interior-heat is flourishing, and fire-toxin is scurried into bone deeply, stops up stagnant not all rightly, and domination of heat meat is rotten, and rottenness of muscle forming pus accumulates the rotten bone of pus; 3) essence in kidney is not enough, and the heresy of YIN-cold is attacked deeply, strongly fragrant in stagnating, heat and lose bone; 4) heresy of cold-damp is because of people's void, deeply attacks volt knot, strongly fragrant heat-transformation of a specified duration, the sluggish passages through which vital energy circulates QI and blood of damp and hot heresy, suppuration and the injury of the bone.

Chinese medicine thinks that fire-toxin is the principal contradiction of primary disease all the time.Its pathogenesis, for the evil poison of impression, is stopped up and is held back muscles and bones, stops up strongly fragrant suppuration, thus should be with heat-clearing and toxic substances removing in treatment, and removing the necrotic tissue and promoting granulation is main.This disease develops into the later stage, must consume excess of four natures in foods or drugs causing damage of essence, and damage of essence is suffered from a deficiency of the kidney, and suffering from a deficiency of the kidney, bone is not solid.Chronic osteomyelitis is " prolonged illness must the stasis of blood " with the passing of time more not, stagnation of QI-blood, and affected part is lost in moistening and is supported and be difficult to healing.

The famous doctor's Chen Shigong of the Ming Dynasty is pointed out in < < Waike Zhengzong, Orthodox Manual of External Diseases > >: " husband pyogenic infection of the bone person; be YIN-cold disease to the marrow also; people's QI and blood life is sturdy, though meet cold heresy not to the marrow ".Healthy energy interior-deficiency is described, clear pathogen invasion and attack,

Vital QI cannot conquer pathogen, the evil poison body on the contrary that can not fall apart is outward scurried into bone, therefore adopts benefiting vital QI and blood, reinforcing body resistance, the Therapeutic Principle in eliminating the toxic material out by tonification.

Chronic osteomyelitis is for years not to heal, outbreak repeatedly, loss body, deficiency of qi and blood, spleen kidney deficiency.Due to interior, have evil poison residual, apoplexy due to deficiency has reality, so although local symptom is had outstanding performance, answer part and whole combination in treatment, strengthening vital QI to eliminate pathogenic factors, works as benefiting vital QI and blood therefore control, warming the kidney and strengthening the spleen, Tuoli removing toxic substances.In the present invention, the Radix Astragali, Radix Angelicae Sinensis, Radix Glycyrrhizae, Herba Psychotriae Siamicae invigorating the spleen and replenishing QI yang invigorating, promote the production of body fluid and nourish blood, strengthening vital QI to eliminate pathogenic factors, and promoting pus discharge and tissue regeneration strengthening, is monarch drug altogether.Radix Rehmanniae Preparata, the Radix Angelicae Dahuricae, the Radix Paeoniae Alba, Poria, native broken benefit, Herba Taxilli, Endothelium Corneum Gigeriae Galli, Cornu Cervi Pantotrichum kidney and spleen invigorating, hemopoietic benefit essence, YIN nourishing promoting tissue regeneration and ulcer healing, is ministerial drug altogether.Assistant is with Herba Taraxaci, Radix Glycyrrhizae, Cortex berberidis dasystachyae, Flos Lonicerae, Spina Gleditsiae clearing away heat-damp and promoting diuresis, and Scorpio, Eupolyphaga seu steleophaga eliminating fire and detoxication, remove residual evil poison.Air Bladder pseudosciaenae seu Acipenser, Cortex Cinnamomi, Periostracum Cicadae, the Endoconcha Sepiae nourishing YIN and benefiting blood that promotes the production of body fluid, coordinating the actions of various ingredients in a prescription is for making.Eupolyphaga seu steleophaga has the merit of removing blood stasis, reunion of fractured tendons and bones, and all medicines in full side have to mend to have and rush down, treating both the principal and secondary aspects of a disease, concurrence qi and blood invigorating, spleen reinforcing kidney, the effect of strengthening vital QI to eliminate pathogenic factors granulation promoting.

Summary of the invention

The invention provides a kind ofly for preventing and treating Chinese medicine of chronic osteomyelitis and preparation method thereof, select medical material according to the reason of monarch, be carefully dished up, the all medicines in full side have to mend to have and rush down, treating both the principal and secondary aspects of a disease, row qi and blood invigorating, benefit essence is filled out marrow, spleen reinforcing kidney, strengthening vital QI to eliminate pathogenic factors, the effect that has granulation promoting, evident in efficacy, make spleen kidney healthy and vigorous, QI and blood is unobstructed, modern pharmacological research demonstration, Chinese medicine of the present invention also has antibacterial bacteriostatic, enhancing human body immunity ability, improves the effects such as blood vessel microcirculation.

For achieving the above object, technical scheme of the present invention is implemented as follows:

For preventing and treating a Chinese medicine for chronic osteomyelitis, raw material composition and the parts by weight of making described effective ingredient are:

Raw material composition and the parts by weight of making described effective ingredient are:

Raw material composition and the parts by weight of making described effective ingredient are:

For preventing and treating a preparation method for the Chinese medicine of chronic osteomyelitis, comprise following processing step:

1) by Herba Taraxaci, Cortex Cinnamomi, Cortex berberidis dasystachyae, native broken benefit, Myrrha, the Radix Angelicae Dahuricae, Periostracum Cicadae, Scorpio, decontamination, pulverize, cross 120 order fine powders, standby;

2) Radix Angelicae Sinensis, Herba Taxilli, Cornu Cervi Pantotrichum, Eupolyphaga seu steleophaga are chosen to decontamination, clean, section is dried, and uses yellow wine uniform spraying, slightly vexed, puts a pot people and fries with low baking temperature, takes out, and cools, and pulverizes 120 order fine powders, standby;

3) by the Radix Paeoniae Alba, Spina Gleditsiae roguing, section, mixes thoroughly with rice vinegar, and in slightly vexed rearmounted pot, by slow fire heating, fried dry, taking-up cools, and grinds into powder, crosses 120 order fine powders, standby;

4) Endothelium Corneum Gigeriae Galli is chosen to decontamination, rinse and dry, first sand is put into a pot people and made popular, Endothelium Corneum Gigeriae Galli is put into pot, with literary composition, for stirring to brown color or coke yellow, heave, take out, sieve shakeout, taking-up cools, and grinds into powder, crosses 120 order fine powders, standby;

5) by Endoconcha Sepiae, remove clothing, clean and chop up piece, with vinegar, mix thoroughly, put in pot, with slow fire heating, fry to micro-yellow, take out, cool, after pulverizing, cross 120 order fine powders, standby;

6) by Air Bladder pseudosciaenae seu Acipenser, Radix Glycyrrhizae, clean decontamination, after dissolving, be condensed into frozen glue, ashing sustainability, standby;

7) Herba Psychotriae Siamicae, Flos Lonicerae, Lignum Sappan, Radix Rehmanniae Preparata, the Radix Astragali, Poria are put into container, the purified water that adds 5 times of amounts of Six-element medicine gross weight, soak 4 hours, decoct to boiling, continue to decoct to 2 hours, leach medicinal liquid, in remaining medicinal residues, add again the purified water of 3 times of amounts, decoct to boiling, continue to decoct 1 hour, leach medicinal liquid; Merge medicinal liquid twice, standby;

8) by step 7) medicinal liquid and the step 1 of gained), step 2), step 3), step 4), step 5) fine powder and the step 6 of gained) the ash end of gained mixes, stir, the thick paste of relative density 1.15～1.21 under 60 ℃ of environment of simmer down to, add vaseline, evenly be mixed into stiff paste, with modern science production technology, be prepared as the capsule of unguentum or every 1.25g.

The property of medicine of the present invention's Chinese medicine used is as follows:

Herba Taraxaci: bitter in the mouth; Sweet; Cold in nature.Return liver; Stomach warp.Heat-clearing and toxic substances removing; Eliminating carbuncle eliminating stagnation.Cure mainly lung abscess; Intestinal carbuncle; Mumps; Furuncle carbuncle toxin; Conjunctival congestion and swelling pain; Cold, fever; Cough; Laryngopharynx swelling and pain; Stomach-fire; Intestinal is scorching; Dysentery; Hepatitis; Cholecystitis; Urinary tract infection; Snake bite and insect sting.< < the southern regions of the Yunnan Province book on Chinese herbal medicine > > carries: " control all pyogenic infections from tumour or sore, ruined tinea skin ulcer; Dispel the wind, all sores that disappears, loose scrofula tuberculosis; Stop little having blood in stool, control the five types of stranguria difficulty in urination, sharp bladder." clinic study shows, dandelion preparation can replace antibiotics to use to a certain extent, some disease is shown to the effect of broad-spectrum antibiotic, has certain antiviral functions.

Radix Angelicae Sinensis: sweet in the mouth; Pungent; Warm in nature.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation; Menstruction regulating and pain relieving; Loosening bowel to relieve constipation.Cure mainly blood deficiency and yellow complexion; Dizzy cardiopalmus; Asthenia cold abdominalgia; Rheumatic arthralgia; Injury from falling down; Ulcer sores.The positive > > of < < book on Chinese herbal medicine carries: " its sweet in the mouth and weigh; therefore specially can enrich blood; its gas is light and pungent, thus again can promoting the circulation of blood, can support nutrition blood; QI invigorating spermatogenesis; settling five organs, body by force, beneficial mind; all tangible deficient diseases, nothing is unsuitable." modern medicine study confirmation, antibacterial, antiinflammation that Radix Angelicae Sinensis has, to chronic rheumatoid arthritis, acute attack has obvious inhibitory action.

The Radix Paeoniae Alba: bitter in the mouth; Property is put down.Enter liver; Spleen channel.Nourishing blood to suppress the hyperactive liver, slow middle pain relieving; Yin fluid astringing is received antiperspirant.Cure mainly the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency.< < does not record > > and carries: " clear and coherent blood vessels, in delaying, dispelling malignant blood, expelling extravasated blood, the gas that anhydrates, sharp bladder, intestine and small intestine, subduing inflammation, row cold and heat while controlling, attacked by pestiferous factors stomachache, lumbago." modern medicine study confirms; the Radix Paeoniae Alba can regulate immunity; strengthen macrophage and leukocytic phagocytic function; regulate the immunologic function of T lymphocyte and body fluid; protect the liver, spasmolytic, analgesia, calmness, resist cool, cooling effect; in addition smooth muscle is had to inhibitory action, the effect of enhancing anoxia enduring, antioxidation and resisting fatigue.

Herba Psychotriae Siamicae: bitter in the mouth; Cool; Property is sweet.Return lung; Liver; Spleen channel.There is heat clearing away; Dampness removing; The effect of hemostasis.Cure mainly conjunctival congestion distending pain; Pterygium; Gonorrhea; Icterohepatitis.< < Yunnan Chinese herbal medicine selects > > to carry: heat-clearing and toxic substances removing, pain relieving.

Flos Lonicerae: sweet in the mouth; Cold in nature.Enter lung; Stomach warp.Heat-clearing and toxic substances removing.Cure mainly epidemic febrile disease heating; Toxic-heat and blood stasis; The capable skin ulcer of carbuncle; Sore throat and multi-infection disease.< < explaining abstruseness of the canon of materia medica > > carries: " tonify deficiency is treated wind for main distension dysentery, the loose poison of eliminating carbuncle; common people but know the merit of its sterilization; hide the use of its swollen sharp wind void, in all diseases of minor, with it, take effect repeatedly." clinic study shows; Flos Lonicerae has significant antibacterial and antivirus action; staphylococcus aureus, Hemolytic streptococcus, dysentery, typhoid fever, meningococcus, Diplococcus pneumoniae, bacillus pyocyaneus and influenza virus are had to obvious inhibitory action; can strengthen function of immune system; promote lymphocyte transformation; strengthen leukocytic phagocytic function, promotes the release of adrenocortical hormone, and inflammation is had to obvious inhibitory action.

The Radix Astragali: sweet in the mouth; Warm in nature.Enter the heart; Lung; Spleen; Kidney channel.Invigorating QI to consolidate the body surface resistance; Diuresis; Expelling pus and toxin by strengthening QI; Promoting tissue regeneration and ulcer healing.Cure mainly the cardiopalmus of breathing hard; Asthenia; Weak; Spontaneous perspiration; Night sweat; Chronic diarrhea; Body is impractical swollen; Chronic nephritis; Carbuncle is difficult bursts; Or burst and do not hold back for a long time.The book on Chinese herbal medicine outline > > of < < Xinhua carries: " the function that has invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, granulation promoting." modern medicine study confirms; Radix Astragali main component is Radix Astragali total flavones, Radix Astragali Mongolici total polysaccharide, Radix Astragali total saponins and aminoacid etc.; have diuretic antihypertensive, anti-inflammatory analgesic, heart tonifying, antioxidant radical generates and improve the multiple pharmacological effect such as body's immunity; can act on from many aspects body, improves the relevant blood vessel sexually transmitted disease (STD)s such as cardiovascular, cerebrovascular, diabetes, nephropathy and becomes the functions such as patient's hemodynamics and vascular endothelial cell.

Radix Rehmanniae Preparata: sweet in the mouth; Warm in nature; Return liver; Kidney channel.Enrich blood moist; Benefit essence is filled out marrow.Cure mainly blood tiger sallow; Dizzy cardiopalmus; Hepatic and renal YIN deficiency; Soreness of the waist and knees; The dyspnea with rapid and short breath of suffering from a deficiency of the kidney.< < book on Chinese herbal medicine converges says that > > carries: " the cloudy wound of prolonged illness, newly produces blood and lose, the essential person of institute also." modern medicine study confirmation, Radix Rehmanniae Preparata can strengthen GSH-Px activity, reduces the content of LPO in serum, improves plasma A D concentration, also has closely-related effect in addition with medulla hematopoietic system.

Herba Taxilli: bitter in the mouth; Sweet; Property is put down.Enter liver; Kidney channel.Invigorating the liver and kidney; Bone and muscle strengthening; Wind-damp dispelling.Cure mainly soreness of waist and knee joint; A little less than muscles and bones flaccidity; Limbs are hemiplegia; Rheumatic arthralgia; Have a dizzy spell.The < < book on Chinese herbal medicine > > that looks for the truth carries: " edge kidney governing bones, sends out blood main, bitter man's kidney, and kidney must mend that muscles and bones is strong, unlikely hemorrhoid repeatly and sensation of aching.Sweet enriching blood, blood must mend send out be subject to its fill with shady and not Fructus Citri tangerinae come off.Therefore in all and lumbago, the sincere disease of muscles and bones, tire are fallen, outer and incised wound, skin rheumatism." modern medicine study confirmation; Herba Taxilli has blood pressure lowering, arrhythmia, increase coronary flow, improves coronary circulation, strengthens cardiac contractile force, reduces myocardial oxygen consumption, anticoagulant, and antithrombotic forms, improves many effects such as microcirculation, antitumor action, treatment hepatitis.

Radix Glycyrrhizae: sweet in the mouth; Property is put down.GUIXIN; Lung; Spleen; Stomach warp.Invigorating the spleen and replenishing QI; Heat-clearing and toxic substances removing; Expelling phlegm for arresting cough; Relieving spasm to stop pain; Coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach; Fatigue and weakness; Shortness of breath and palpitation; Cough with copious phlegm; Gastral cavity abdomen four muscle spasm of the leg and foot pain; Carbuncle sore tumefacting virus; Cushion toxicity.< < Compendium of Materia Medica > > carries: " in all medicines, Radix Glycyrrhizae is monarch.Control 72 kinds of mammary calculus poison, draft is malicious by every means to separate 1,002, is in harmonious proportion from medicine meritorious." modern medicine study confirmation, Radix Glycyrrhizae has stronger Detoxication, also has antiulcer, anti-inflammatory, spasmolytic antitussive, blood pressure lowering, blood fat reducing, antitumaous effect.

Poria: sweet in the mouth; Light; Property is put down.Enter the heart; Spleen; Lung; Kidney channel.Eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.Cure mainly dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Let out wash with watercolours; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine.< < does not record > > and carries: " only quench one's thirst, like to sleep, large abdomen, drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema is drenched knot.Open breast internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, physical strength profiting, during guarantor god keeps." modern medicine study confirmation; Poria all has inhibitory action to staphylococcus aureus, escherichia coli, Bacillus proteus etc.; can kill the antibacterials such as leptospira; digestive system, blood system and central nervous system are had to certain protective effect; pachyman content is very high in addition, can anti-tumor activity.

Lignum Sappan: sweet in the mouth; Salty; Property is put down; Nontoxic.GUIXIN; Liver; Stomach; Large intestine channel.There is blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain.Cure mainly carbuncle, traumatic injury, tetanus.Modern medicine study confirmation, Lignum Sappan Decoction can significantly promote arteriole blood flow, promotes the recovery of microcirculation and caliber.

Cortex berberidis dasystachyae: bitter in the mouth; Cold in nature.Return lung; Stomach; Large intestine channel.There is clearing away damp-heat; Relieving heat toxin.There is hygropyretic dysentery; Jaundice; Leukorrhagia; The effect of pyretic toxicity carbuncle.

The broken benefit of soil: mildly bitter flavor; Cool in nature.There is relaxing muscles and tendons and activating QI and blood in the collateral; Heat-clearing and toxic substances removing; Reducing swelling and alleviating pain.Cure mainly rheumatic arthralgia; Traumatic injury; Carbuncle sore tumefacting virus.

Myrrha: bitter in the mouth; Pungent; Property is put down.Enter liver, spleen, the heart, kidney channel.Cure mainly traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, ulcer sore pain, loose blood blood stasis removing, reducing swelling and alleviating pain.< < Bencao Jingshu > > carries: " control ulna arthralgia and breast abdomen side of body costalgia." modern medicine study confirmation, Myrrha is like hormone, and scalable thyroid, has powerful antiinflammatory, sterilization, pain relieving and resists viral function.

The Radix Angelicae Dahuricae: acrid in the mouth; Warm in nature.Return lung; Spleen; Stomach warp.Expelling wind and removing dampness; Understand things pain-stopping; Detumescence and apocenosis.Cure mainly supraorbital bone pain; Toothache; Nasal obstruction; Nasal sinusitis; Domination of damp pathogen chronic diarrhea; Ulcer sores; Venom.< < detailed outline > > carries: " control nasal sinusitis, epistaxis, toothache, supraorbital bone pain, large intestine constipation due to pathogenic wind, bleeding urine, married woman's blood dizziness due to wind pathogen is dizzy, and regurgitation of food from the stomach is told food; Solution arsenic poison, snakebite, cutter arrow incised wound." modern medicine study confirms, the Radix Angelicae Dahuricae has excitation to central nervous system, can suppress hepatic drug metabolizing enzyme system, has in addition the effects such as antipyretic-antalgic, antiinflammatory, antibacterial, blood pressure lowering, can activate sympathetic system hormone, suppresses lipogenesis.

Spina Gleditsiae: acrid in the mouth; Warm in nature.Return liver; Lung meridian.There is the saturating pus of sterilization; Search wind; Parasite killing; Cure mainly swollen ulcer drug; Scrofula; Skin ulcer rash stubborn dermatitis; Leprosy.The high former > > of < < book on Chinese herbal medicine carries: remove air slaking expectorant, counteracting toxic substances relieves internal heat.Determine infantile convulsion and send out and jerk, attack variola and rise and send out, removing toxic substances pulping.

Endothelium Corneum Gigeriae Galli: sweet in the mouth; Property is put down.Return spleen; Stomach; Kidney; Urinary bladder channel.Strengthening the spleen to promote digestion; Arresting seminal emission; Xiao Disorder fossil.Cure mainly dyspepsia; Eating accumulation; Vomiting regurgitation; The dysentery of having loose bowels; Infantile malnutrition; Seminal emission; The enuresis; Frequent micturition; Urinary system calculus and cholelithiasis; Mass in the abdomen amenorrhea; Sore throat tonsillitis; Ulcerative gingivitis aphtha.< < Compendium of Materia Medica > > carries: " control children's's intermittent fever due to retention of food, treatment adult is dripping, regurgitation, and the wine that disappears is long-pending, main inflammation of the throat, tonsillitis, all aphthas, all skin ulcers of ulcerative gingivitis." the clinical confirmation of modern medicine, Endothelium Corneum Gigeriae Galli is used for the treatment of the various diseases such as dyspepsia, chronic gastritis, cholelithiasis, cystitis, vesical calculus, oral ulcer, the seminal emission enuresis, gastric cancer, liver cirrhosis, has good curative effect.

Air Bladder pseudosciaenae seu Acipenser: sweet in the mouth; Property is put down.Return kidney; Liver Channel.There is invigorating the liver and kidney; Nourishing blood and hemoslasis; The effect of dissipating blood stasis for subsidence of swelling.Cure mainly emission due to deficiency of the kidney; Weakness of the waist and knees; Ischemic spasm; Tetanus; Epilepsy; Traumatic hemorrhage; Carbuncle of yin nature; Fistula; Chronic ulcer; Chap; Gout.< < Compendium of Materia Medica > > carries: fish glue, and only injured blood goes out incessantly; Bladder glue, charred medicinal herb with its property retained, tetanus convulsion, preventing or arresting vomiting blood, dissipating blood stasis blood, detumescence poison, nourishing muscle and tendon arteries and veins; Determine hands war; Controlling nocturnal emission with astringent drugs.

Periostracum Cicadae: sweet in the mouth; Salty; Cool in nature.Enter lung; Liver Channel.Modern medicine study confirms, Periostracum Cicadae has obvious convulsion, sedation, can block parasympathetic conduction on neck, is widely used in treating that tetanus, chronic Herba Urticae Cannabinae are examined, suppurative otitis media, vasodilation, in addition also have cough-relieving to cough, the particularly effect of coughing of itching of the throat.

Cornu Cervi Pantotrichum: sweet in the mouth; Salty; Warm in nature.Enter kidney; Liver Channel.Invigorating kidney-YANG; Benefiting essence-blood; Bone and muscle strengthening; Holder sore.Cure mainly kidney yang deficiency; Asthenia is won thin; Mental fatigue fear of cold; Dizzy; Hiccough and deaf; Aching pain in waist and back; Muscles and bones flaccidity is soft; .< < Bencao Jingshu > > carries: " treat the voluminous symptoms like malaria of asthenia, weakness and emaciation, painful limbs, pain along the spinal column; normal urination, let out essence, hematuria, and broken stagnant blood is at abdomen; loose stranguria caused by urinary stone, carbuncle, heat in bone, cellulitis is itched." modern medicine study confirms; Cornu Cervi Pantotrichum contains abundant aminoacid, lecithin, vitamin and trace element; can improve cellular immunization and the humoral immune function of body; promote lymphocytic conversion; have the effect of immunopotentiating agent; can also increase body defence capability to external world, the immunologic balance in control agent and avoid disease to occur and promote wound healing, sick body rehabilitation.

Scorpio: acrid in the mouth; Property is put down; Poisonous.Enter Liver Channel.Expelling wind and relieving convulsion; Removing obstruction in the collateral to relieve pain; Dispersing pathogen accumulation.Modern medicine study shows, the charybdotoxin that Scorpio contains has significant spasmolysis, and convulsion suppresses vasomotor center, and blood vessel dilating, lowers adrenergic pressurization, has significant sedation.

Cortex Cinnamomi: acrid in the mouth; Bitter; Hot in nature.Enter kidney; Spleen; The heart; Liver Channel.Mend fire supporing yang; Let the fire back to its origin; Dispersing cold for relieving pain; Warming the meridian and promoting blood circulation.Cure mainly insufficiency of kidney-YANG; Gate of vitality's fire; Aversion to cold and cold limbs; Soreness of the waist and knees; Impotence and seminal emission; Dysuria or frequency; The dyspnea with rapid and short breath of losing heart; The all cards of edema oliguria; Decline of the fire from the gate of life; Fire is Gui Yuan not; Floating YANG; Refusing yang; And heat in the upper and cold in the lower; Flushed complexion cold foot; Spleen-kidney vacuity cold; Coldness and pain in the epigastrium; Decreased food intake loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain; Or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus; Or do not hold back after bursting.< < property of medicine opinion > > carries: " cure mainly nine types of precordial pain, kill three worms, main removing blood stasis; the tonneau moon closes; control weak foot, numbness, meciless, retention of placenta; except cough with dyspnea; stagnation of QI, gather around numbness, only cold air in abdomen, unbearably painful; main dysentery, nasal polyp.Herbicide wood poison." modern medicine study confirmation, Cortex Cinnamomi contains the compositions such as cinnamic aldehyde, cinnamyl acetate, acetoxyphenyl group the third cheese, has the effect of fragrant stomach invigorating, antipyretic-antalgic, anti-inflammation.

Eupolyphaga seu steleophaga: salty in the mouth; Cold in nature; Mild toxicity.Return Liver Channel.There is removing blood stasis; The effect of reunion of fractured tendons and bones; Cure mainly blood stasis amenorrhea; Mass in the abdomen amasss piece; Traumatic injury congestive edema; Muscles and bones fracture; Swollen and rigid tongue congenital deformity of the tongue.< < book on Chinese herbal medicine carries through sulfur > >: front yard worm, control injury from falling down, and reuniting the fractured tendons and bones has special effect.Be that foot turns round and look at yin channel medicine also.Husband's blood sees, also Kidney-Yin in body irrigated bones of the body collectively, and office flows through network person also.If blood stagnates, blockage of main and collateral channels, use of negative and positive is well-behaved mutually, and cold and heat are washed and here are given birth to.Salty-cold energy human blood softening the hard mass, therefore main trusted subordinate's accumulation of blood, topic abdominal mass blood closes all cards.Blood and and battalion defends unobstructedly, cold and heat are from removing, passages through which vital energy circulates is mixed well.

Endoconcha Sepiae: salty in the mouth; Puckery; Warm in nature.Return liver; Kidney channel.There is astringing to arrest bleeding; Treating spontaneous emission and leukorrhagia; Relieving gastric hyperacidity to alleviate stomachache; Removing dampness is used skin ulcer; Cure mainly haematemesis; Hematemesis; Epistaxis; Wound hemorrhage; Emission due to deficiency of the kidney spermatorrhea.< < Bencao Jingshu > >: sepia bone, salty in the mouth, feeble QI temperature is nontoxic, enters sufficient jump the moon, shaoyin channel.Fainting cloudy is the viscus of storing blood,

The present invention compared with prior art, has following beneficial effect:

The present invention selects medical material according to the reason of monarch, is carefully dished up, and all medicines in full side have to mend to have and rush down, treating both the principal and secondary aspects of a disease, row qi and blood invigorating, beneficial essence is filled out marrow, spleen reinforcing kidney, strengthening vital QI to eliminate pathogenic factors, has the effect of granulation promoting, evident in efficacy, make spleen kidney healthy and vigorous, QI and blood is unobstructed, the demonstration of clinical verification data, and Chinese medicine of the present invention also has antibacterial bacteriostatic, enhancing human body immunity ability, improves the effects such as blood vessel microcirculation.

The specific embodiment

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material of effective ingredient of the present invention forms and weight is:

The processing step of process for preparing medicine of the present invention is:

1) by Herba Taraxaci, Cortex Cinnamomi, Cortex berberidis dasystachyae, native broken benefit, Myrrha, the Radix Angelicae Dahuricae, Periostracum Cicadae, Scorpio, decontamination, pulverize, cross 120 order fine powders, standby;

2) Radix Angelicae Sinensis, Herba Taxilli, Cornu Cervi Pantotrichum, Eupolyphaga seu steleophaga are chosen to decontamination, clean, section is dried, and uses yellow wine uniform spraying, slightly vexed, puts a pot people and fries with low baking temperature, takes out, and cools, and pulverizes 120 order fine powders, standby;

3) by the Radix Paeoniae Alba, Spina Gleditsiae roguing, section, mixes thoroughly with rice vinegar, and in slightly vexed rearmounted pot, by slow fire heating, fried dry, taking-up cools, and grinds into powder, crosses 120 order fine powders, standby;

4) Endothelium Corneum Gigeriae Galli is chosen to decontamination, rinse and dry, first sand is put into a pot people and made popular, Endothelium Corneum Gigeriae Galli is put into pot, with literary composition, for stirring to brown color or coke yellow, heave, take out, sieve shakeout, taking-up cools, and grinds into powder, crosses 120 order fine powders, standby;

5) by Endoconcha Sepiae, remove clothing, clean and chop up piece, with vinegar, mix thoroughly, put in pot, with slow fire heating, fry to micro-yellow, take out, cool, after pulverizing, cross 120 order fine powders, standby;

6) by Air Bladder pseudosciaenae seu Acipenser, Radix Glycyrrhizae, clean decontamination, after dissolving, be condensed into frozen glue, ashing sustainability, standby;

7) Herba Psychotriae Siamicae, Flos Lonicerae, Lignum Sappan, Radix Rehmanniae Preparata, the Radix Astragali, Poria are put into container, the purified water that adds 5 times of amounts of Six-element medicine gross weight, soak 4 hours, decoct to boiling, continue to decoct to 2 hours, leach medicinal liquid, in remaining medicinal residues, add again the purified water of 3 times of amounts, decoct to boiling, continue to decoct 1 hour, leach medicinal liquid; Merge medicinal liquid twice, standby;

8) by step 7) medicinal liquid and the step 1 of gained), step 2), step 3), step 4), step 5) fine powder and the step 6 of gained) the ash end of gained mixes, stir, the thick paste of relative density 1.15～1.21 under 60 ℃ of environment of simmer down to, add vaseline, evenly be mixed into stiff paste, with modern science production technology, be prepared as the capsule of unguentum or every 1.25g.

Usage and dosage: capsule, for oral administration, warm boiled water, each 2, every day 3 times; Unguentum, external application, with non-woven fabrics wrapping, changes and applies once for every 24 hours, within 20 days, is a course for the treatment of.

Embodiment 2

The raw material of effective ingredient of the present invention forms and weight is:

Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

Embodiment 3

The raw material of effective ingredient of the present invention forms and weight is:

Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

Embodiment 4

Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

Embodiment 5

Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

Clinical data:

1, case selection

The routine clinical observation of chronic osteomyelitis patient 180 of selecting the court to make a definite diagnosis, patient is divided into treatment first group, treatment second group, contrast first group and contrast second group at random.Wherein, treatment first group 15 people, comprise male patient 9 people, female patient 6 people, maximum 79 years old age, minimal ages 17 years old, 39.2 years old mean age; Contrast first group 15 people, comprise male patient 8 people, female patient 7 people, maximum 74 years old age, minimal ages 21 years old, 41.2 years old mean age; Treatment second group 15 people, comprise male patient 10 people, female patient 5 people, maximum 68 years old age, minimal ages 16 years old, 35.7 years old mean age; Contrast second group 15 people, comprise male patient 9 people, female patient 6 people, maximum 71 years old age, minimal ages 20 years old, 36.2 years old mean age.

2, treatment group patient takes respectively the capsule described in the embodiment of the present invention, and adult every day 3 times, each oral 2, affected part apply the plaster described in the embodiment of the present invention, and within every 24 hours, change one and paste, within 20 days, be a course for the treatment of.Matched group is according to the classification of the chronic osteomyelitis of diagnosing out, give respectively oral hydrochloride levofloxacin, clindamycin, amoxicillin, cephalo ammonia Kaifeng, etc. the treatment means of anti-infectives.

3, efficacy determination:

(1) recovery from illness: symptom and sign disappears, and x-ray shows without sequestrum, bone repair, without recurrence.

(2) take a turn for the better: whole body and local symptom sign disappear, x-ray shows that sclerotin take a favorable turn or stablizes.

(3) invalid: x-ray demonstration sclerotin is not repaired, and symptom is with treating front no significant difference.

4, comparing result (table one vides infra):

Table one contrast therapeutic effect log

Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.

Model case is given an example:

1, Zhao * *, man, 35 years old.Patient's right lateral thigh swells and ache, the high heat shiver with cold of burst is extracted pus out after local hospital puncture, is diagnosed as non-healing wounds after " thigh portion abscess " surgical incision evacuation of pus, do X-ray film inspection and show that femur has sclerotin to break and shows, by " osteomyelitis treatment ", give antibiotic, bad during state of an illness fashion, after several months, find that there is an open sore part a burst inner side, left side, surrounding skin darkens, and has obvious tenderness and percussion pain.X-ray film checks, is diagnosed as chronic osteomyelitis, takes the embodiment of the present invention after 3 courses for the treatment of, wound healing, and local pain disappears, and x-ray inspection exists without sequestrum, so far not recurrence.

2, poplar * *, female, 39 years old.Suffer from femur bone marrow inflammation 3 years protracteds course of disease, invalid through several hospital therapies, invite remaining diagnosis and treatment disease to see tunnel, along sinus tract, often flow out pus blood and slime, remove after wound surface, along sinus tract external application plaster of the present invention, within 24 hours, change once, and take capsule of the present invention simultaneously and fully recover after 4 courses for the treatment of.

3, model * *, man, 27 years old.Left kneecap inflammation, redness is suppurated, and by certain large hospital, is diagnosed as chronic osteomyelitis, takes antibiotic therapy, bad during state of an illness fashion, to our hospital upon somebody's introduction, pulse condition stringy and rapid pulse, picture of the tongue point limit is red, greasy fur, diagnosis: three warmers fire is contained, and turbid damp poison accumulates, takes 5 recoveries from illness course for the treatment of of capsule of the present invention.

4, Guo * *, female, 32 years old.This patient rides electric motor car traumatic injury, causes elbow joint congestion and swelling pain, does not prolongedly heal.By X-ray film, be diagnosed as subperiosteal abscess, Soft Tissue Abscess: An Experimental.Through antibacterial therapy after a while, effect is not remarkable, pain aggravation.During Lai Wo institute diagnosis and treatment, find that there is the probability that fistula hole occurs, take capsule of the present invention, every day three times, each oral 2, through the treatment of 2 courses for the treatment of, X-ray film shows that its subperiosteal abscess and Soft Tissue Abscess: An Experimental all disappear, red and swollen phenomenon disappears, pain disappears, and continues to take 1 course for the treatment of of the present invention, is consolidated, follow up a case by regular visits to half a year, not recurrence.

5, Tan * *, man, 58 years old.The left lower limb knee joint of patient's readme bottom is red and swollen, and broken skin ulcer is suppurated, and tenderness sense is strong, long-term disunion.Repeatedly attempt drug for diminishing inflammation and antibiosis treatment, outbreak, drops out fritter sequestrum after half a year repeatedly, and swollen joint increases slightly, existing lopsided symptom, and walking sitting and lying has lost capacity of will.Through taking capsule of the present invention after 2 courses for the treatment of, the symptom that swells and ache is alleviated to some extent, and the open sore part phenomenon of suppurating alleviates, and tenderness sense thaws; Continue to take capsule of the present invention after 3 courses for the treatment of, recovery from illness.

Clinical summary

Clinical verification through five assembly ratios, data show, the symptom effect highly significants such as the high heat that Chinese medicine of the present invention causes osteomyelitis, local pain, diabrosis, stream chamber, sequestrum or cavity, initial stage patient's cure rate is reached to 75% left and right, patient with severe symptoms also has obvious improvement, reaches the drug effect standard of clinical application completely, compares with traditional treatment means, easy to use, cost is low, is a kind of desirable osteomyelitis control medication.

Claims (4)

1. for preventing and treating a Chinese medicine for chronic osteomyelitis, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

2. according to claim 1 a kind of for preventing and treating the Chinese medicine of chronic osteomyelitis, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

3. according to claim 1 a kind of for preventing and treating the Chinese medicine of chronic osteomyelitis, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

4. for preventing and treating a preparation method for the Chinese medicine of chronic osteomyelitis, it is characterized in that: comprise following processing step:

1) by Herba Taraxaci, Cortex Cinnamomi, Cortex berberidis dasystachyae, native broken benefit, Myrrha, the Radix Angelicae Dahuricae, Periostracum Cicadae, Scorpio, decontamination, pulverize, cross 120 order fine powders, standby;

2) Radix Angelicae Sinensis, Herba Taxilli, Cornu Cervi Pantotrichum, Eupolyphaga seu steleophaga are chosen to decontamination, clean, section is dried, and uses yellow wine uniform spraying, slightly vexed, puts a pot people and fries with low baking temperature, takes out, and cools, and pulverizes 120 order fine powders, standby;

3) by the Radix Paeoniae Alba, Spina Gleditsiae roguing, section, mixes thoroughly with rice vinegar, and in slightly vexed rearmounted pot, by slow fire heating, fried dry, taking-up cools, and grinds into powder, crosses 120 order fine powders, standby;

4) Endothelium Corneum Gigeriae Galli is chosen to decontamination, rinse and dry, first sand is put into a pot people and made popular, Endothelium Corneum Gigeriae Galli is put into pot, with literary composition, for stirring to brown color or coke yellow, heave, take out, sieve shakeout, taking-up cools, and grinds into powder, crosses 120 order fine powders, standby;

5) by Endoconcha Sepiae, remove clothing, clean and chop up piece, with vinegar, mix thoroughly, put in pot, with slow fire heating, fry to micro-yellow, take out, cool, after pulverizing, cross 120 order fine powders, standby;

6) by Air Bladder pseudosciaenae seu Acipenser, Radix Glycyrrhizae, clean decontamination, after dissolving, be condensed into frozen glue, ashing sustainability, standby;

7) Herba Psychotriae Siamicae, Flos Lonicerae, Lignum Sappan, Radix Rehmanniae Preparata, the Radix Astragali, Poria are put into container, the purified water that adds 5 times of amounts of Six-element medicine gross weight, soak 4 hours, decoct to boiling, continue to decoct to 2 hours, leach medicinal liquid, in remaining medicinal residues, add again the purified water of 3 times of amounts, decoct to boiling, continue to decoct to 1 hour, leach medicinal liquid; Merge medicinal liquid twice, standby;

8) by step 7) medicinal liquid and the step 1 of gained), step 2), step 3), step 4), step 5) fine powder and the step 6 of gained) the ash end of gained mixes, stir, the thick paste of relative density 1.15～1.21 under 60 ℃ of environment of simmer down to, add vaseline, evenly be mixed into stiff paste, with modern science production technology, be prepared as the capsule of unguentum or every 1.25g.