CN103550641A - Kidney essence pill formula for treating chronic pyelonephritis and preparation method of kidney essence pill - Google Patents

Abstract

The invention discloses a kidney essence pill formula for treating chronic pyelonephritis and a preparation method of the kidney essence pill, belonging to the technical field of traditional Chinese medicine formula. The kidney essence pill comprises the following raw materials of effective ingredients in parts by weight: 20-38g of rhizoma smilacis glabrae, 15-30g of Chinese yam, 15-30g of phymatopsis hastata, 10-30g of red bean, 10-30g of semen coicis, 12-28g of oyster, 9-24g of tortoise shell, 6-15g of morinda officinalis, 9-15g of lophatherum gracile, 7-15g of cortex lycii radicis, 5-12g of rhizoma alismatis, 4-12g of sparganii rhizoma, 4-10g of earthworm, 3-11g of myrrh, 3-9g of salvia miltiorrhiza, 3-9g of golden cypress, 3-8g of tangerine seed, and 1-3g of endothelium corneum gigeriae galli. The kidney essence pill formula is perfect in selecting raw materials and unique in compatibility of medicines, aims at pathogeny of nephritis such as spleen-kidney-yang deficiency, urination disorder, and retention of damp-heat in the interior, has effects on clearing heat and promoting diuresis, detoxifying and treating stranguria, inducing diuresis to alleviate edema, tonifying kidney and nourishing blood. The kidney essence pill is prepared through reasonable combination of raw materials. Clinical verification shows that the kidney essence pill has good absorption effect, obvious curative effect, no toxic and side effects, and no clinical adverse reaction, meets clinical requirements, is an ideal pill for curing kidney.

Description

The prescription kidney essense ball and the preparation method that are used for the treatment of chronic pyelonephritis

Affiliated technical field

The present invention relates to Chinese medicine, in particular for prescription kidney essense ball and the preparation method for the treatment of chronic pyelonephritis.

Background technology

Chronic pyelonephritis is that antibacterial infects the chronic inflammatory disease that kidney causes, part patient has predisposing factor to exist, as urinary tract obstruction, deformity, nephroptosis and vesico-ureteric reflux etc.Pathological changes is mainly invaded kidney interstitial and renal pelvis, renal calices tissue.Due to inflammation, continue to carry out or repeatedly cause kidney interstitial, renal pelvis, the infringement of renal calices; form cicatrix; so that kidney generation atrophy and occur dysfunction, patient may only have the soreness of waist and low grade fever at ordinary times, can there is no the dysurea of obvious urinary tract infection; frequent micturition and symptoms of urgency; its main manifestations be nocturia increase and urinate in have a small amount of leukocyte and albumen etc., albumen is the source of human life normal activity, the loss of albumen is that kidney can not controlling nocturnal emission with astringent drugs; lose manyly, deficiency of qi and blood is more serious.Pyelonephritis protracted course of disease, prolonged illness must be become silted up, pathogen usually intruding into collateral in protracted disease, kidney network becomes silted up and hinders, and nephron is downright bad, and glomerular sclerosis makes kidney atrophy, and then renal failure (being uremia), jeopardizes the vital organs of the human body and life.

Because chronic pyelonephritis is a kind of inflammation, doctor trained in Western medicine system is to its general anti-inflammatory treatment that adopts, conventionally select antibacterial sensitivity and toxicity is less, and the antibiotic all in excess of the kidney matter and urine with higher concentration, adopt the longer course for the treatment of (generally over 4 weeks or 6 weeks), to reach the object of thorough removing antibacterial.Applicable antibiotic mainly contains cephalosporin, ampicillin, carbenicillin, ethyl because of shuttle mycin Sulfamethoxazole Compound or nitrofurantoin etc. at present.Though these antimicrobial drugs have certain therapeutical effect, but antimicrobial drug can not complete and remove antibacterial on the one hand, urinary tract infection is acute attack repeatedly easily, for improving bacteria clearance, need to adopt the low dosage antimicrobial therapeutics of the long course for the treatment of, need at least medication more than 1 year, life-time service antibiotic, produces drug resistance; On the other hand, antibiotic has certain infringement to human body autoimmune system, and kidney is the very important organ of metabolism, once medicine accumulate cause poisoning, not only in nephritis without solution, can increase the weight of symptom on the contrary.

Traditional Chinese medical theory thinks, kidney be body this, disease of kidney, is the deficiency of the kidney tune of becoming homeless for a long time of suffering from a deficiency of the kidney.As traditional disease, motherland's medical science has accumulated a large amount of classical prescription proved recipes in the very long years, these classical prescription proved recipes, generally with deficiency of spleen-YANG and kidneyYANG, retention of damp-heat in the interior for starting with a little, take clearing away heat-damp and promoting diuresis, detoxify treating stranguria, inducing diuresis to remove edema as through, warming the kidney and strengthening the spleen, kidney tonifying nourish blood as big, adopt rational Chinese prescription, reduce the loss of albumen in urine, increase the synthetic of liver albumen, thereby support kidney and adjust kidney, reach the object of curing the sickness to save the patient.In the last few years, between traditional medicine and doctor trained in Western medicine system, mutually confirm, inspire, also formed the scheme of some therapy of combining Chinese and Western medicine chronic pyelonephritiss, but these schemes of overall view, all belong to the recycling to traditional classical prescription proved recipe, select medicine to avoid urgency, especially dare not select the medical material of micro-poison, mild toxicity, drug effect is mild, benefit foster and be negligent of stagnant, be good at stream and idle in attacking, significant discomfort is answered modern allegro city life, and curative effect does not significantly promote.

Summary of the invention

The invention provides the prescription kidney essense ball and the preparation method that are used for the treatment of chronic pyelonephritis, the effect that there is clearing away heat-damp and promoting diuresis, treating stranguria, the inducing diuresis to remove edema of detoxifying, warming the kidney and strengthening the spleen, kidney tonifying nourishes blood, cure the disease and ask source treating both the principal and secondary aspects of a disease, the chronic pyelonephritis that a variety of causes is caused all has good curative effect.

For achieving the above object, technical scheme of the present invention is implemented as follows: be used for the treatment of the prescription kidney essense ball of chronic pyelonephritis, raw material composition and the parts by weight of making described effective ingredient are:

Rhizoma Smilacis Glabrae 20～38g, Rhizoma Dioscoreae 15～30g, Herba Lepisori Thunbergiani 15～30g, Semen Phaseoli 10～30g, Semen Coicis 10～30g, Concha Ostreae 12～28g, Carapax Et Plastrum Testudinis 9～24g, Radix Morindae Officinalis 6～15g, Herba Lophatheri 9～15g, Cortex Lycii 7～15g, Rhizoma Alismatis 5～12g, Rhizoma Sparganii 4～12g, Pheretima 4～10g, Myrrha 3～11g, RADIX SALVIAE MILTIORRHIZAE 3～9g, Cortex Phellodendri 3～9g, Semen Citri Reticulatae 3～8g, Endothelium Corneum Gigeriae Galli 1～3g.

Raw material composition and the parts by weight of making described effective ingredient are:

Rhizoma Smilacis Glabrae 25～35g, Rhizoma Dioscoreae 18～25g, Herba Lepisori Thunbergiani 18～23g, Semen Phaseoli 15～22g, Semen Coicis 15～26g, Concha Ostreae 14～25g, Carapax Et Plastrum Testudinis 12～20g, Radix Morindae Officinalis 8～12g, Herba Lophatheri 10～14g, Cortex Lycii 9～13g, Rhizoma Alismatis 7～10g, Rhizoma Sparganii 6～10g, Pheretima 6～8g, Myrrha 5～10g, RADIX SALVIAE MILTIORRHIZAE 4～7g, Cortex Phellodendri 4.5～8g, Semen Citri Reticulatae 4～6g, Endothelium Corneum Gigeriae Galli 1.5～2.5g

Raw material composition and the parts by weight of making described effective ingredient are:

Rhizoma Smilacis Glabrae 28g, Rhizoma Dioscoreae 22g, Herba Lepisori Thunbergiani 22g, Semen Phaseoli 17g, Semen Coicis 20g, Concha Ostreae 18g, Carapax Et Plastrum Testudinis 13g, Radix Morindae Officinalis 10g, Herba Lophatheri 12g, Cortex Lycii 11g, Rhizoma Alismatis 9g, Rhizoma Sparganii 9g, Pheretima 7g, Myrrha 6g, RADIX SALVIAE MILTIORRHIZAE 5g, Cortex Phellodendri 5g, Semen Citri Reticulatae 5g, Endothelium Corneum Gigeriae Galli 2g.

Be used for the treatment of the prescription kidney essense ball of chronic pyelonephritis and the preparation method of preparation method, comprise following processing step:

1) after coarse sand is put into pot and made popular, Carapax Et Plastrum Testudinis, Endothelium Corneum Gigeriae Galli are put into pot, with slow fire, stir and to epidermis, present brown color for several times and heave, take out, sieve shakeout, cools rear pulverizing and grinds into powder, crosses 140 order fine powders, standby.

2) by Rhizoma Dioscoreae peeling, be soaked in water to Rhizoma Dioscoreae central part and soften as degree, to pull out slightly and dry in the air, section is dried, first the even spreading of wheat bran is heated in heat pot, then yam slice is put into pot, with slow fire, evenly stir-fry to faint yellow, take out, sieve removes wheat bran, cools rear pulverizing, crosses 140 order fine powders, standby.

3) by Cortex Phellodendri decontamination, after water is first clean, section, dries, and gets Cortex Phellodendri sheet and sprays with saline, mixes thoroughly, puts in pot with the micro-stir-fry of slow fire, and taking-up cools, and dries rear pulverizing and grinds into powder, crosses 140 order fine powders, standby.

4) get clean Semen Citri Reticulatae, with saline, mix thoroughly, slightly vexed, put into pot, slow fire is fried to micro-yellow, and has fragrance degree of being, shells and gets core, and taking-up is dried, and pulverizing is ground into powder, crosses 120 order fine powders, standby.

5) Pheretima is removed to impurity, clean, cutting, is ground into fine powder after drying, standby.

6) after Herba Lepisori Thunbergiani is cleaned being mashed, cross 120 order drainage screens, taking juice, standby.

7) Radix Morindae Officinalis, RADIX SALVIAE MILTIORRHIZAE are put into container, add the shaoxing wine of four times of amounts, boil rear continuation and soak 3～5 hours, leach immersion; In remaining medicinal residues, add again the shaoxing wine of triplication, boil rear continuation and soak 2～3 hours, leach immersion; Merge twice gained immersion, under heating simmer down to room temperature environment, the thick paste of relative density 1.10～1.22 is standby.

8) by Semen Phaseoli, Semen Coicis, Rhizoma Smilacis Glabrae, Concha Ostreae, Herba Lophatheri, Cortex Lycii, Rhizoma Alismatis, Rhizoma Sparganii, Myrrha and step 5) described in Pheretima put into container, the purified water that adds six times of amounts, soaks 6～8 hours, decocts to boiling, continue to decoct 2 hours, get immersion; In remaining medicinal residues, add the purified water of four times of amounts, soak 3～5 hours, decoct to boiling, continue to decoct 1 hour, get immersion; Merge twice gained immersion, under 60 ℃ of environment of simmer down to, the thick paste of relative density 1.15～1.25, standby.

9) by step 1), step 2), step 3), step 4), step 5) fine powder and the step 6 of gained) juice that makes, with step 7), step 8) thick paste that makes mixes, add Mel to stir, with modern science production technology, make described pill product.

Described Semen Citri Reticulatae, Cortex Phellodendri sheet are 40:1 with the proportioning of salt respectively.

The property of medicine of the present invention's Chinese medicine used is as follows:

Rhizoma Smilacis Glabrae: sweet in the mouth; Light; Property is put down.Enter the heart; Spleen; Lung; Kidney channel.Eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.Cure mainly dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Let out wash with watercolours; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine.< < does not record > > and carries: " only quench one's thirst, like to sleep, large abdomen, drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema is drenched knot.Open breast internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, physical strength profiting, during guarantor god keeps." modern medicine study confirmation; Poria all has inhibitory action to staphylococcus aureus, escherichia coli, Bacillus proteus etc.; can kill the antibacterials such as leptospira; digestive system, blood system and central nervous system are had to certain protective effect; pachyman content is very high in addition, can anti-tumor activity.

Rhizoma Dioscoreae: sweet in the mouth; Property is put down.Enter lung; Spleen; Kidney channel.Spleen reinforcing; Support lung; Reinforce the kidney; Benefit essence.Cure mainly diarrhea due to hypofunction of the spleen; Lack of appetite edema; Cough and asthma due to lung deficiency; Quench one's thirst; Seminal emission; Leukorrhagia; The frequent micturition of suffering from a deficiency of the kidney; Carbuncle is controlled in external; Scrofula.The positive > > of < < book on Chinese herbal medicine carries: " Rhizoma Dioscoreae, energy spleen invigorating tonify deficiency, grows essence and reinforce the kidney, and controls weakness, treats five kinds of strain and seven kinds of impairment." modern medicine study confirms, Rhizoma Dioscoreae can reduce blood glucose, regulates body to non-specific irritant reaction, effectively resists the Immunosuppression effect of cyclophosphamide, stimulates intestinal motility, promotes that intestinal contents is emptying, in addition can also be aid digestion, antidiarrheal, eliminate the phlegm.

Herba Lepisori Thunbergiani: sweet in the mouth; Light; Cold nature.Return lung; Liver; Kidney; Urinary bladder channel.Clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Improving eyesight; Eliminate the phlegm.Cure mainly dysuria; Stranguria with turbid discharge leukorrhagia; Edema distension; Heat-damp in summer dysentery; Conjunctival congestion is hidden from view; Expectorant heat syndrome cough is breathed heavily.< < Japan hanako materia medica > > carries: " diuresis drenches puckery, tonifying YANG.Control de-essence, vexed, the therapeutic method to keep the adverse QI flowing downwards." modern medicine study confirmation, Semen Plantaginis has remarkable diuresis, can promote respiratory mucus secretion, dilution sputum, and various bacillus and staphylococcus are had to remarkable inhibitory action.

Semen Phaseoli: sweet in the mouth; Acid; Cold nature.GUIXIN; Spleen; Kidney; Small intestine meridian.There is inducing diuresis to remove edema jaundice eliminating; The effect of heat-clearing and toxic substances removing eliminating carbuncle.Cure mainly edema; Foot gas; Jaundice; Gonorrhea; Have blood in stool; Toxic swelling skin infection; Scall.< < Compendium of Materia Medica > >: Semen Phaseoli, its property is descending, and logical small intestinal can enter cloudy minute, controls tangible disease.Therefore promoting circulation of body fluid, diuresis, relieving distension is except swollen, emesis and to control the inferior dysentery intestinal out-of-the-way, and the disease of relieving the effect of alcohol, except cold and heat carbuncle, all tangible person of disease.Clothes fall order too for a long time, and body fluid oozes to be let out, so make leanness heavy sensation of the body also.Its nasal insufflation Guadi San and ward off pestilence with it, also gets its ventilation dehumidifying heat radiation ear.

Semen Coicis: sweet in the mouth; Light; Cold nature.Enter spleen; Lung; Kidney channel.Dampness removing spleen invigorating; Arthralgia relieving by relaxing muscles and tendons; Clearing away heat and discharging pus.Cure mainly edema; Foot gas; Dribbling urination; Damp-warm diseases; The leukorrhagia of having loose bowels; Rheumatic arthralgia; The contracture of muscle arteries and veins; Lung abscess; Verruca plana.The positive > > of < < book on Chinese herbal medicine carries: " slightly sweet flavor; feeble QI is cool; property edges down and oozes, therefore the diuretic that can dry is wet with its will; therefore the sharp joint of energy; except beriberi, controls the weak contracture arthralgia chiefly caused by damp pathogen of flaccidity, and consumer edema pain; diuresis pyretic stranguria, also kills ascarid.With it, edge down, therefore also control the pus of sleeping of coughing, sharp diaphragm appetizing.Cool in nature with it, therefore can heat clearing away, only excessive thirst, upper gas." modern medicine study discovery, Semen Coicis is a kind of heat-staple trypsin inhibitor, has significant antitumor action, blood sugar lowering, blood calcium, blood pressure have obvious inhibitory action to cervical cancer and ascitic type liver cancer solid tumor, also have in addition stronger immunization.

Concha Ostreae: salty in the mouth; Cold nature.Enter liver; Kidney channel.Suppressing the hyperactive liver and subsiding YANG; Tranquillization with heavy prescription; Hard masses softening and resolving; Restrain astringent or styptic treatment for spontaneous sweating.Cure mainly vertigo and tinnitus; Palpitation with fear insomnia; Scrofula goiter; WEIJIA mass in the abdomen; Spontaneous sweating; Seminal emission; Metrorrhagia; Leukorrhagia.< < Compendium of Materia Medica > > carries: " resolving phlegm and softening hard masses, removing damp-heat stop heart temper pain, under dysentery, and reddish and whitish turbid urine, the hernia that disappears abdominal mass is amassed piece, wart disease tuberculosis." modern medicine study confirmation, Concha Ostreae has convergence, calmness, removing toxic substances, analgesic effect, and acidic extraction thing has inhibitory action to poliovirus.

Carapax Et Plastrum Testudinis: taste becomes; Sweet; Be slightly cold.Return liver; Kidney; Heart channel.There is nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, the effect of the reinforcing the heart of nourishing blood.Cure mainly deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and muscles and bones flaccidity is soft, has a guilty conscience forgetful.

Radix Morindae Officinalis: bitter in the mouth; Pungent; Warm in nature.Enter Liver Channel.Expelling wind and removing dampness; Dredge the meridian passage; Reducing swelling and alleviating pain.< < Hunan medicine will > > carries: " relaxing muscles and tendons to promote blood circulation, invigorating qi and dredging collateral.Control lumbago, arthralgia, amenorrhea." modern medicine study shows, Herba Lycopodii contains the alkaloids such as lycopodine, excellent lycoclavanin alkali, and terpenoid, sterol and acids, has cooling, hypotensive activity, can strengthen heart contraction dynamics, and excited smooth muscle also has bacteriostasis in addition.

Herba Lophatheri: sweet in the mouth; Light; Cold in nature.GUIXIN; Small intestinal; Lung; Stomach warp.Heat clearing away; Relieving restlessness; Diuresis.Cure mainly dysphoria with smothery sensation thirsty; Children's's night crying due to fright in infant; Hot urination; Stranguria with turbid discharge.The < < SHENGCAO property of medicine is standby wants > > to carry: " expectorant is quenched the thirst, except part of the body cavity above the diaphragm housing the heart and lungs fire, and bright eyes, diuresis, controls nebulousurine, brings down a fever, loose hemorrhoid poison." modern medicine study shows, Herba Lophatheri has significant refrigeration function, can increase the excretion of urine chloride, and staphylococcus aureus, Hemolytic streptococcus are had to inhibitory action, the effect of the blood glucose that raises in addition in addition.

Cortex Lycii: sweet in the mouth; Cold in nature.Enter lung; Kidney channel.Clearind deficient heat; Purte the white; Removing heat from blood.Cure mainly hectic fever due to deficiency of YIN; Hectic fever due to YIN-deficiency night sweat; Hematuria; Quench one's thirst.< < book on Chinese herbal medicine is stated > > and is carried: " cure mainly deficient fever, alternate attacks of chills and fever, is allly shown in blood disorder, epistaxis, lumbago, migratory arthralgia; beriberi, edema, and fidgets due to deficiency, throbs with fear; forgetful, urinary obstruction, reddish and whitish turbid urine." modern medicine study confirmation, the derivant that Cortex Lycii contains guanidine, has hypoglycemic activity, and the infringement of insulin β cellular morphology structure is had to certain effect that alleviates, and can block SNE and direct vasodilator.

Rhizoma Alismatis: sweet in the mouth; Light; Cold in nature.Return kidney; Urinary bladder channel.Promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria.Cure mainly dysuria; The puckery pain of pyretic stranguria; Edema distension; Have loose bowels; Dizziness due to fluid-retention; Seminal emission.< < does not record > > and carries: " tonifying deficiency five kinds of over strain, except the five internal organs feeling of fullness, plays cloudy gas, stopping leak essence, quenches one's thirst, drenches drop, by bladder, three warmers, cuts off the water." modern medicine study confirmation, Rhizoma Alismatis has the cholesterol of reduction and atherosclerosis effect, improves liver lipid metabolism, reduces blood glucose, blood pressure, affects function of immune system, reduces serum hemolysin.

Rhizoma Sparganii: acrid in the mouth; Puckery; Cool in nature.Enter liver; Spleen channel.Removing blood stasis circulation of qi promoting; Removing food stagnancy pain relieving.Cure mainly lump in the abdomen mass in the abdomen; Food stagnation distending pain.< < Japan hanako materia medica > > carries: " control married woman's blood vessels uncomfortable, cardiac and abdominal pain, tire falls; the stagnant blood that disappears, and mends labor, logical menstruation; control flatulence, disappear and flutter damage blood stasis, puerperal abdonimal pain, blood fortune stagnated blood not under." modern medicine study confirms, Rhizoma Sparganii can be strengthened intestinal tube and shrink, and there is to excitation in uterus, can anticoagulant, extend thrombus formation time, melt thrombosis, reduce whole blood viscosity.

Pheretima: salty in the mouth; Cold in nature.Return liver; Spleen; Urinary bladder channel.Clear gesture relieving convulsion; Suppressing the hyperactive liver to relieve the wind syndrome; Dredge the meridian passage; The diuresis of relievining asthma.Cure mainly calentura heating mad dry; Infantile convulsion is twitched; Headache due to hyperactivity of liver-YANG; Apoplectic hemiplegia; Rheumatic arthralgia; Dyspnea and cough due to lung-heat; Urinary obstruction.< < Compendium of Materia Medica > > carries: " cold in nature and descending, cold in nature therefore can separate all hot diseases, descending former energy diuresis, control sufficient disease and the meridian dredging also.Main typhoid fever malaria, large fanatical tired, and children's's adult urinary obstruction, anxious chronic infantile convulsion, severe and migratory arthralgia pain." modern medicine study proves, Pheretima contains the compositions such as ground LONGSU, lumbrofebrin, vitamin B complex complex, has diuresis, eases pain, relievings asthma, the effect such as blood pressure lowering, analgesic, convulsion.

Myrrha: bitter in the mouth; Pungent; Property is put down.Enter liver, spleen, the heart, kidney channel.Cure mainly traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, ulcer sore pain, loose blood blood stasis removing, reducing swelling and alleviating pain.< < Bencao Jingshu > > carries: " control ulna arthralgia and breast abdomen side of body costalgia." modern medicine study confirmation, Myrrha is like hormone, and scalable thyroid, has powerful antiinflammatory, sterilization, pain relieving and resists viral function.

RADIX SALVIAE MILTIORRHIZAE: bitter in the mouth; Cold nature; Nontoxic.Enter the heart; Liver Channel.Promoting blood flow to regulate menstruation; Stasis-dispelling and pain-killing; Removing heat from blood eliminating carbuncle; Relieving restlessness clears away heart-fire; Nourishing blood to tranquillize the mind.Cure mainly trusted subordinate's pathogen; Cold and heat gather; Ailment said due to cold or exposure is stayed heat.< < herbal classic > > carries: " main trusted subordinate's pathogen, borborygmus are faint as leaked water, and cold and heat gather; Broken disease, except abdominal mass, is stopped stuffy sensation with restlessness, QI invigorating." modern medicine study confirms; Radix Salviae Miltiorrhizae can improve plasmin activity; extend hemorrhage, clotting time; anticoagulant; coronary artery dilating and peripheral blood vessel, increases myocardial flow, promotes reparation and the regeneration of tissue; promote the formation of fibroblast differentiation and collagen fiber, suppresses synthesizing of originality cholesterol in cell.

Cortex Phellodendri: bitter in the mouth; Cold in nature.Enter kidney; Urinary bladder channel.Heat clearing and damp drying; Eliminating fire and detoxication.Cure mainly hygropyretic dysentery, have loose bowels, jaundice; Nocturnal emission, stranguria with turbid discharge, leukorrhagia; Hectic fever due to YIN-deficiency consumptive fever; And aphtha of the mouth and tongue; Conjunctival congestion and swelling pain; Skin sore; Skin eczema.< < medicineization justice > > carries: " pathogenic fire reducing can be capit ad calcem, and the thorough marrow of the skin that falls is invariably thoughtful, specially rushes down the fire of kidney and bladder." modern medicine study confirms, Cortex Phellodendri is containing main components such as berberine, obacunone, has the effect of antibiotic, convergence, antiinflammatory, and to symptoms such as various skin noxious dampness, skin infection, effect is good.

Semen Citri Reticulatae: bitter in the mouth; Property is put down.Return liver; Kidney; Urinary bladder channel.Have and regulate the flow of vital energy; Eliminating stagnation; The effect of pain relieving.Cure mainly hernia; Painful and swollen testis; Acute mastitis; Lumbago.< < Japan hanako materia medica > > carries: control lumbago, bladder gas, kidney pain.

Endothelium Corneum Gigeriae Galli: sweet in the mouth; Property is put down.Return spleen; Stomach; Kidney; Urinary bladder channel.Strengthening the spleen to promote digestion; Arresting seminal emission; Xiao Disorder fossil.Cure mainly dyspepsia; Eating accumulation; Vomiting regurgitation; The dysentery of having loose bowels; Infantile malnutrition; Seminal emission; The enuresis; Frequent micturition; Urinary system calculus and cholelithiasis; Mass in the abdomen amenorrhea; Sore throat tonsillitis; Ulcerative gingivitis aphtha.< < Compendium of Materia Medica > > carries: " control children's's intermittent fever due to retention of food, treatment adult is dripping, regurgitation, and the wine that disappears is long-pending, main inflammation of the throat, tonsillitis, all aphthas, all skin ulcers of ulcerative gingivitis." the clinical confirmation of modern medicine, Endothelium Corneum Gigeriae Galli is used for the treatment of the various diseases such as dyspepsia, chronic gastritis, cholelithiasis, cystitis, vesical calculus, oral ulcer, the seminal emission enuresis, gastric cancer, liver cirrhosis, has good curative effect.

The present invention compared with prior art, has following beneficial effect:

The present invention selects medical material to meet a monarch and his subjects left side and makes it reason, for causes of disease such as deficiency of spleen-YANG and kidneyYANG, disturbance in water passage, water-damp not being transformed, retention of damp-heat in the interior, the effect that have clearing away heat-damp and promoting diuresis, treating stranguria, the inducing diuresis to remove edema of detoxifying, warming the kidney and strengthening the spleen, kidney tonifying nourishes blood, through clinical verification, good absorbing effect, evident in efficacy, have no side effect and clinical adverse.

The specific embodiment

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material of effective ingredient of the present invention forms and weight is:

Rhizoma Smilacis Glabrae 35g, Rhizoma Dioscoreae 25g, Herba Lepisori Thunbergiani 23g, Semen Phaseoli 22g, Semen Coicis 26g, Concha Ostreae 25g, Carapax Et Plastrum Testudinis 20g, Radix Morindae Officinalis 12g, Herba Lophatheri 14g, Cortex Lycii 13g, Rhizoma Alismatis 10g, Rhizoma Sparganii 10g, Pheretima 8g, Myrrha 10g, RADIX SALVIAE MILTIORRHIZAE 7g, Cortex Phellodendri 8g, Semen Citri Reticulatae 6g, Endothelium Corneum Gigeriae Galli 2.5g.

The processing step of process for preparing medicine of the present invention is:

1) after coarse sand is put into pot making popular, Carapax Et Plastrum Testudinis, Endothelium Corneum Gigeriae Galli are put into pot, with slow fire, stir and to epidermis, present brown color for several times and heave, take out, sieve shakeout, cools rear pulverizing and grinds into powder, crosses 140 order fine powders, standby.

2) by Rhizoma Dioscoreae peeling, be soaked in water to Rhizoma Dioscoreae central part and soften as degree, to pull out slightly and dry in the air, section is dried, first the even spreading of wheat bran is heated in heat pot, then yam slice is put into pot, with slow fire, evenly stir-fry to faint yellow, take out, sieve removes wheat bran, cools rear pulverizing, crosses 140 order fine powders, standby.

3) by Cortex Phellodendri decontamination, after water is first clean, section, dries, and gets Cortex Phellodendri sheet and sprays with saline, mixes thoroughly, puts in pot with the micro-stir-fry of slow fire, and taking-up cools, and dries rear pulverizing and grinds into powder, crosses 140 order fine powders, standby.

4) get clean Semen Citri Reticulatae, with saline, mix thoroughly, slightly vexed, put into pot, slow fire is fried to micro-yellow, and has fragrance degree of being, shells and gets core, and taking-up is dried, and pulverizing is ground into powder, crosses 120 order fine powders, standby.

5) Pheretima is removed to impurity, clean, cutting, is ground into fine powder after drying, standby.

6) after Herba Lepisori Thunbergiani is cleaned being mashed, cross 120 order drainage screens, taking juice, standby.

7) Radix Morindae Officinalis, RADIX SALVIAE MILTIORRHIZAE are put into container, add the shaoxing wine of four times of amounts, boil rear continuation and soak 3～5 hours, leach immersion; In remaining medicinal residues, add again the shaoxing wine of triplication, boil rear continuation and soak 2～3 hours, leach immersion; Merge twice gained immersion, under heating simmer down to room temperature environment, the thick paste of relative density 1.10～1.22 is standby.

8) by Semen Phaseoli, Semen Coicis, Rhizoma Smilacis Glabrae, Concha Ostreae, Herba Lophatheri, Cortex Lycii, Rhizoma Alismatis, Rhizoma Sparganii, Myrrha and step 5) described in Pheretima put into container, the purified water that adds six times of amounts, soaks 6～8 hours, decocts to boiling, continue to decoct 2 hours, get immersion; In remaining medicinal residues, add the purified water of four times of amounts, soak 3～5 hours, decoct to boiling, continue to decoct 1 hour, get immersion; Merge twice gained immersion, under 60 ℃ of environment of simmer down to, the thick paste of relative density 1.15～1.25, standby.

9) by step 1), step 2), step 3), step 4), step 5) fine powder and the step 6 of gained) juice that makes, with step 7), step 8) thick paste that makes mixes, add Mel to stir, with modern science production technology, make described pill product.

Usage and dosage: be grown up each 3 times, each 0.75～1.25g, one hour after meal with warm water delivery service; Patient with severe symptoms every day 4 times, each 1.00～1.50g, within one hour after meal, with warm water delivery service, 5 days courses for the treatment of, the light patient of disease takes effect 1 course for the treatment of, and patient with severe symptoms takes effect 2 courses for the treatment of.

Embodiment 2

The raw material of effective ingredient of the present invention forms and weight is:

Rhizoma Smilacis Glabrae 28g, Rhizoma Dioscoreae 22g, Herba Lepisori Thunbergiani 22g, Semen Phaseoli 17g, Semen Coicis 20g, Concha Ostreae 18g, Carapax Et Plastrum Testudinis 13g, Radix Morindae Officinalis 10g, Herba Lophatheri 12g, Cortex Lycii 11g, Rhizoma Alismatis 9g, Rhizoma Sparganii 9g, Pheretima 7g, Myrrha 6g, RADIX SALVIAE MILTIORRHIZAE 5g, Cortex Phellodendri 5g, Semen Citri Reticulatae 5g, Endothelium Corneum Gigeriae Galli 2g.

Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

Embodiment 3

The raw material of effective ingredient of the present invention forms and weight is:

Rhizoma Smilacis Glabrae 25g, Rhizoma Dioscoreae 18g, Herba Lepisori Thunbergiani 18g, Semen Phaseoli 15g, Semen Coicis 15g, Concha Ostreae 14g, Carapax Et Plastrum Testudinis 12g, Radix Morindae Officinalis 8g, Herba Lophatheri 10g, Cortex Lycii 9g, Rhizoma Alismatis 7g, Rhizoma Sparganii 6g, Pheretima 6g, Myrrha 5g, RADIX SALVIAE MILTIORRHIZAE 4g, Cortex Phellodendri 4.5g, Semen Citri Reticulatae 4g, Endothelium Corneum Gigeriae Galli 1.5g.

Process for preparing medicine processing step and the usage and dosage of the present embodiment are identical with embodiment 1.

Clinical data:

1, case selection

The routine clinical observation of chronic pyelonephritis patient 80 of selecting Wo Yuanhuo outer court to make a definite diagnosis, patient is divided into two groups at random.Treatment group 40 examples, male's 28 examples wherein, the age is at 35～55 years old, women's 12 examples, the age was at 32～55 years old.Matched group 40 examples, male's 25 examples, the age is at 30～54 years old, women's 15 examples, the age was at 30～58 years old.Two groups of qualifications and record of service are basically identical, without significant difference, have comparability.

2, treatment group patient takes medicine of the present invention, adult every day 3 times, and each oral 0.75～1.25g, patient with severe symptoms every day 4 times, each 1.00～1.50g, 5 days is a course for the treatment of, in 250～360 days, cures.Matched group is according to the chronic pyelonephritis of diagnosing out, give respectively cephalosporin, ampicillin, carbenicillin, ethyl because for the treatment of meanss such as shuttle mycin Sulfamethoxazole Compound or nitrofurantoins, within 10 days, be a course for the treatment of, just rehabilitation gradually in 300～600 days, small number of patients recurs again.

3, efficacy determination:

(1) recovery from illness: the clinical symptoms such as frequent micturition, urgent micturition, dysurea, dizziness disappear entirely.

(2) take a turn for the better: serum urea nitrogen, creatinine clearance rate are stablized, and routine urinalysis is at normal range value.

(3) invalid: symptom is with treating front no significant difference.

4, result

In treatment group, cure 30 examples, 6 examples that take a turn for the better, invalid 4 examples, cure rate 85%, total effective rate 95%.

In matched group, cure 8 examples, 11 examples that take a turn for the better, invalid 21 examples, cure rate 20%, total effective rate 47%.

Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.

Group	n	Cure	Take a turn for the better	Invalid	Average cure time (d)	Cure rate %	Effective percentage %
								Matched group	40	8	11	21	10	20％	47％
Treatment group	40	30	6	4	5	85％	95％

Clinical conclusion

In sum, through clinical use kidney essense ball of the present invention, its prescription and concocting method, although to some case still need the long period continue take medicine, for this pertinacious disease of chronic nephropathy, can obtain up to 85% treatment more, not easy.Kidney essense ball preparation process of the present invention is comparatively complicated, compatibility is partially very partially high, but through careful process of preparing Chinese medicine operation, has avoided the toxicity that may exist in prescription medical material, complete the safety criterion and the criterion of therapeutical effect that have reached clinical application, possessed the clinical condition of applying on a large scale.

Claims (5)

1. the prescription kidney essense ball that is used for the treatment of chronic pyelonephritis, is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:

Rhizoma Smilacis Glabrae 20～38g, Rhizoma Dioscoreae 15～30g, Herba Lepisori Thunbergiani 15～30g, Semen Phaseoli 10～30g, Semen Coicis 10～30g, Concha Ostreae 12～28g, Carapax Et Plastrum Testudinis 9～24g, Radix Morindae Officinalis 6～15g, Herba Lophatheri 9～15g, Cortex Lycii 7～15g, Rhizoma Alismatis 5～12g, Rhizoma Sparganii 4～12g, Pheretima 4～10g, Myrrha 3～11g, RADIX SALVIAE MILTIORRHIZAE 3～9g, Cortex Phellodendri 3～9g, Semen Citri Reticulatae 3～8g, Endothelium Corneum Gigeriae Galli 1～3g.

2. the prescription kidney essense ball that is used for the treatment of chronic pyelonephritis according to claim 1, is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:

Rhizoma Smilacis Glabrae 25～35g, Rhizoma Dioscoreae 18～25g, Herba Lepisori Thunbergiani 18～23g, Semen Phaseoli 15～22g, Semen Coicis 15～26g, Concha Ostreae 14～25g, Carapax Et Plastrum Testudinis 12～20g, Radix Morindae Officinalis 8～12g, Herba Lophatheri 10～14g, Cortex Lycii 9～13g, Rhizoma Alismatis 7～10g, Rhizoma Sparganii 6～10g, Pheretima 6～8g, Myrrha 5～10g, RADIX SALVIAE MILTIORRHIZAE 4～7g, Cortex Phellodendri 4.5～8g, Semen Citri Reticulatae 4～6g, Endothelium Corneum Gigeriae Galli 1.5～2.5g.

3. the prescription kidney essense ball that is used for the treatment of chronic pyelonephritis according to claim 1, is characterized in that, raw material composition and the parts by weight of making described effective ingredient are:

Rhizoma Smilacis Glabrae 28g, Rhizoma Dioscoreae 22g, Herba Lepisori Thunbergiani 22g, Semen Phaseoli 17g, Semen Coicis 20g, Concha Ostreae 18g, Carapax Et Plastrum Testudinis 13g, Radix Morindae Officinalis 10g, Herba Lophatheri 12g, Cortex Lycii 11g, Rhizoma Alismatis 9g, Rhizoma Sparganii 9g, Pheretima 7g, Myrrha 6g, RADIX SALVIAE MILTIORRHIZAE 5g, Cortex Phellodendri 5g, Semen Citri Reticulatae 5g, Endothelium Corneum Gigeriae Galli 2g.

4. the preparation method that is used for the treatment of the prescription kidney essense ball of chronic pyelonephritis, is characterized in that, comprises following processing step:

1) after coarse sand is put into pot and made popular, Carapax Et Plastrum Testudinis, Endothelium Corneum Gigeriae Galli are put into pot, slow fire stirs and to epidermis, presents brown color for several times and heave, and takes out, and sieve shakeout, cools rear pulverizing and grind into powder, crosses 140 order fine powders, standby.

2) by Rhizoma Dioscoreae peeling, be soaked in water to Rhizoma Dioscoreae central part and soften as degree, to pull out slightly and dry in the air, section is dried, first the even spreading of wheat bran is heated in heat pot, then yam slice is put into pot, with slow fire, evenly stir-fry to faint yellow, take out, sieve removes wheat bran, cools rear pulverizing, crosses 140 order fine powders, standby.

3) by Cortex Phellodendri decontamination, after water is first clean, section, dries, and gets Cortex Phellodendri sheet and sprays with saline, mixes thoroughly, puts in pot with the micro-stir-fry of slow fire, and taking-up cools, and dries rear pulverizing and grinds into powder, crosses 140 order fine powders, standby.

4) get clean Semen Citri Reticulatae, with saline, mix thoroughly, slightly vexed, put into pot, slow fire is fried to micro-yellow, and has fragrance degree of being, shells and gets core, and taking-up is dried, and pulverizing is ground into powder, crosses 120 order fine powders, standby.

5) Pheretima is removed to impurity, clean, cutting, is ground into fine powder after drying, standby.

6) after Herba Lepisori Thunbergiani is cleaned being mashed, cross 120 order drainage screens, taking juice, standby.

7) Radix Morindae Officinalis, RADIX SALVIAE MILTIORRHIZAE are put into container, add the shaoxing wine of four times of amounts, boil rear continuation and soak 3～5 hours, leach immersion; In remaining medicinal residues, add again the shaoxing wine of triplication, boil rear continuation and soak 2～3 hours, leach immersion; Merge twice gained immersion, under heating simmer down to room temperature environment, the thick paste of relative density 1.10～1.22 is standby.

8) by Semen Phaseoli, Semen Coicis, Rhizoma Smilacis Glabrae, Concha Ostreae, Herba Lophatheri, Cortex Lycii, Rhizoma Alismatis, Rhizoma Sparganii, Myrrha and step 5) described in Pheretima put into container, the purified water that adds six times of amounts, soaks 6～8 hours, decocts to boiling, continue to decoct 2 hours, get immersion; In remaining medicinal residues, add the purified water of four times of amounts, soak 3～5 hours, decoct to boiling, continue to decoct 1 hour, get immersion; Merge twice gained immersion, under 60 ℃ of environment of simmer down to, the thick paste of relative density 1.15～1.25, standby.

9) by step 1), step 2), step 3), step 4), step 5) fine powder and the step 6 of gained) juice that makes, with step 7), step 8) thick paste that makes mixes, add Mel to stir, with modern science production technology, make described pill product.

5. according to the prescription kidney essense ball and the preparation method that are used for the treatment of chronic pyelonephritis described in claim 1,2,3,4, it is characterized in that: described Semen Citri Reticulatae, Cortex Phellodendri sheet are 40:1 with the proportioning of salt respectively.