CN105687666A

CN105687666A - Traditional Chinese medicine composition for treating chronic gouty arthritis and preparing method of traditional Chinese medicine composition

Info

Publication number: CN105687666A
Application number: CN201610279529.0A
Authority: CN
Inventors: 杨娉萍; 黄娅玲; 台磊
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-05-03
Filing date: 2016-05-03
Publication date: 2016-06-22

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic gouty arthritis and application of the traditional Chinese medicine composition, and belongs to the field of traditional Chinese medicine.The traditional Chinese medicine composition is prepared from radix rehmanniae preparata, radix rehmanniae, antler gum, herba leonuri, radix cudramiae, herba lamiophlomis, Chinese yam, stir-baked semen euryales, ginseng, processed turtle shells, calcined oyster shells, mantis egg-case, radix angelica sinensis, white paeony roots, prepared rhizoma cyperi with vinegar, radix asparagi, rhizoma chuanxiong, starwort roots and licorice roots.The traditional Chinese medicine composition has the effects of strengthening the spleen and tonifying the kidneys, replenishing and nourishing blood, resolving dampness and removing turbidity, and clearing away heat, removing stasis and relieving pain, is remarkable in treatment effect on gouty arthritis, and has the advantages of being high in cure rate, good in treatment effect, short in treatment course, free of side effects and the like.

Description

A kind of Chinese medicine composition treating gouty arthritis,chronic and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition treating gouty arthritis,chronic and application thereof。

Background technology

Gouty arthritis is a kind of disease that the middle-aging male caused by purine metabolic disturbance and underexcretion is common, is divided into acute and chronic clinically。The simple joint red and swollen heat pain that acute gouty arthritis broke out with night is for feature。The visible multiple joint involvement of gouty arthritis,chronic, outbreak frequency, the catabasis shortens, and even after outbreak, pain is not also alleviated。Along with China's growth in the living standard, dietary structure and living-pattern preservation, the increase of fat number, this disease sickness rate just increases rapidly, sharp ache and recurrent exerbation, become big serious problems of puzzlement patient with gout, not only had a strong impact on routine work and the life of patient and family members, and brought white elephant to society。

At present, this disease be there is no radical cure method by modern medicine, acute attack stage commonly uses nonsteroidal antiinflammatory drug, Colchicine and glucocorticoid treatment, but patient with gout is often with kidney, cardiovascular, gastroenteropathy, and the diarrhoea brought of said medicine, gastrointestinal hemorrhage, myocardial infarction, injury of kidney etc. limit the use of Western medicine。Gouty arthritis belongs to the categories such as the traditional Chinese medical science " numbness is sick ", " gout ", " severe and migratory arthralgia "。So, Exploration and application Chinese medicine gout has become a current important research topic。The present inventor is through clinical trial for many years, it was demonstrated that application Gouty Arthritis Treated by Chinese Drugs has curative effect height, the advantage that side effect is little。

Summary of the invention

The invention provides that a kind of effect is obvious, cure rate is high, the Chinese medicine composition of the treatment gouty arthritis,chronic that side effect is little and application thereof。

The present invention is achieved by the following technical solutions:

A kind of Chinese medicine composition treating gouty arthritis,chronic, it is characterised in that be made up of each crude drug of following weight portion: Radix Rehmanniae Preparata 25-40 part, Radix Rehmanniae 25-40 part, Colla cornus cervi 12-25 part, Herba Leonuri 25-40 part, Radix Cudraniae 12-25 part, Radix Lamiophlomidis Rotatae 12-25 part, Rhizoma Dioscoreae 12-25 part, Semen Euryales (parched) 12-25 part, Radix Ginseng 10-25 part, Carapax Trionycis (processed) 6-15 part, Concha Ostreae (calcined) 5-10 part, Ootheca Mantidis 5-10 part, Radix Angelicae Sinensis 12-25 part, Radix Paeoniae Alba 12-25 part, Rhizoma Cyperi (processed with vinegar) 12-25 part, Radix Asparagi 12-25 part, Rhizoma Chuanxiong 12-25 part, Radix Stellariae 2-8 part, Radix Glycyrrhizae 3-6 part。

Preferably, described compositions, it is characterized in that, the weight portion of each crude drug is: 30 parts of Radix Rehmanniae Preparata, Radix Rehmanniae 30 parts, Colla cornus cervi 20 parts, Herba Leonuri 30 parts, Radix Cudraniae 20 parts, Radix Lamiophlomidis Rotatae 20 parts, Rhizoma Dioscoreae 20 parts, Semen Euryales (parched) 20 parts, Radix Ginseng 15 parts, Carapax Trionycis (processed) 10 parts, Concha Ostreae (calcined) 8 parts, Ootheca Mantidis 8 parts, Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 20 parts, Rhizoma Cyperi (processed with vinegar) 20 parts, Radix Asparagi 20 parts, Rhizoma Chuanxiong 20 parts, Radix Stellariae 4 parts, 5 parts of Radix Glycyrrhizae。

Further preferred, the Chinese medicine composition of described treatment gouty arthritis, it is characterised in that: prepare into preparation suitable clinically according to Chinese medicine preparation。Described preparation includes capsule, pill, powder, granule, tablet, oral liquid or drop pill。

Preferably, the preparation method of described compositions, it is characterised in that: weigh each crude drug by described weight portion；Each crude drug is pulverized, sieves, add the adjuvant needed for preparations shaping or excipient, prepare into capsule, tablet or pill。

Further preferred, the preparation method of described compositions, it is characterised in that comprise the following steps:

(1) each crude drug is weighed by described weight portion；

(2) Rhizoma Dioscoreae, Semen Euryales (parched), Rhizoma Cyperi (processed with vinegar), Radix Asparagi, Rhizoma Chuanxiong, Radix Ginseng, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Carapax Trionycis (processed) are pulverized respectively, standby；

(3) by Radix Rehmanniae Preparata, Radix Rehmanniae, Herba Leonuri, Radix Cudraniae, Radix Lamiophlomidis Rotatae, Concha Ostreae (calcined), Ootheca Mantidis, Radix Stellariae and Radix Glycyrrhizae water extraction twice, each 0.5-3 hour, filter, be evaporated to thick paste, standby；

(4) after being pulverized by Colla cornus cervi, the product obtained with step (2) and (3) is mixed homogeneously, and adds Colla cornus cervi comminuted powder and pharmaceutical preparation auxiliary materials and mixing makes intermediate formulations, make finished dosage form then through preparations shaping technique。

Present invention also offers the application in the medicine of preparation treatment gouty arthritis,chronic of the described Chinese medicine composition。

Gout belongs to the categories such as arthromyodynia, gout, severe and migratory arthralgia in Chinese medicine, and the cause of disease is that natural endowment is not enough or decline old internal organs day, is addicted to drink, addiction to greasy and sweet foods savoury in addition, causes visceral dysfunction, pure and impure metabolism disorder。Purine is its pathological product, belongs to motherland's medical science " turbid pathogen " category。Inventor combines and faces the cognition confirmed in trampling in a large number, it is believed that " empty, turbid, hot, the stasis of blood " is the pathogenesis key that development occurs gout, and primary disease is with spleen caused by liver and kidney deficiency, insufficiency of vital energy and blood for this, and turbid damp, stagnant heat numbness resistance passages through which vital energy circulates, joint are mark, deficiency in origin and excess in superficiality。The spleen and stomach provide the material basis of the acquired, source of generating QI and blood, and for the pivot of rising and falling of QI, ascending the clear and descending the turbid, traffic is upper and lower, maintains the gasification function of " lucid YANG ascending to the upper orifices, turbid yin walks lower orifices "。Such as dysfunction of the spleen in transportation, disturbance in functioning of QI, then water-damp retention be can cause, water, wet, expectorant, turbid all heresies produced。The turbid liquid produced after metabolism, by defeated in kidney under three burnt water channels, through the evaporating of kidney qi, opens entire, and clear person is transferring to use and rise in lung by temper again, again participates in water liquid metabolism, and turbid person then turns to urine, under defeated bladder excrete。In the middle of ingesta, delicious food savoury is excessive, the most easily causes damp and hot delaying, its reason except spleen fortune not as good as except, the more importantly the turbid descending malfunction of kidney。" Plain Questions the five internal organs generate a section " cloud: " polyphagia is sweet, then osteodynia and deal with。If " deficiency of spleen and stomach, or diet labor is intended to damage spleen kidney, the transporting of spleen, transfer and kidney evaporate out entire dysfunction, it is impossible to the duty of competent ascending the clear and descending the turbid, turbid damp is detained strongly fragrant and heat-transformation, damp and hot flees in muscles and bones, notes in joint, and the resistance of QI and blood numbness is obstructed, therefore joint swells and ache。Visible, only kidney yin kidney yang coordinated balance, the entire and impetus of evaporating out of kidney qi is brought into normal play, and ascending the clear and descending the turbid function just can be able to Effective Regulation。Otherwise turbid YIN failing to descend, is detained internal, counter become hidden danger。Because of insufficiency of the spleen resulting in production of dampness too, it is impossible to changing essence and receive kidney, the turbid descending of suffering from a deficiency of the kidney is too late, contains and tired spleen in turbid damp, and spleen kidney two is hindered, cause pathogenic factor to be stolen and occupy internal, repeatedly haunt。

Kidney storing essence, just, whether department's two functions just normally depend on the rising gasification of yang-energy in kidney on the one hand, additionally whether normal with liver controlling conveyance and dispersion function closely related in department two。The liver failing to maintain the normal flow of QI can cause spleen weakness, deficiency of kidney-essence, the generation of uric acid can be caused to increase or drain minimizing, causing hyperuricemia, and this causes the requisite pathological process of gout just。Clinically, or because natural endowment is not enough, the addiction greasy and surfeit flavour day after tomorrow, with the passing of time the impairment of the spleen or long-term feelings will internal injury, irritability stasis, disorder of movement of QI, or fleshliness transition, deficiency of kidney-essence, or the imbalance of old spleen hepatic and renal function, endogenous damp formation, accumulate puzzled for a long time, make the raw turbid poison of uric acid, accumulate the raw expectorant of heat-transformation of a specified duration, become raw blockage of phlegm and blood stasis the liver pulse joint and form primary disease。Man is hyperactivity of the ministerial fire usually, and liver insulting spleen, then soil declines and water is turbid, or disturbing the essence-chamber, and causing deficiency of kidney-essence, the liver pulse loses supports, and cause the liver failing to maintain the normal flow of QI, and spleen weakness, deficiency of kidney-essence, produce uric acid turbid pathogen, and woman belongs to cloudy, its property is peaceful, and fire is not easily recklessly acted mutually, and with liver for congenital, The liver and the kidney have a common source, the first syntrophism day after tomorrow, and spleen is not easily empty, after climacteric, kidney essense begins to lose, liver spleen renal dysfunction, this is probably gout morbidity man more than female, and its ratio is about 20: 1, age is many more than 40 years old, and women is often in the reason of sequela climacteric。" Plain Questions the five internal organs generate a section " is said: " liver governing tendons, all muscle persons come under joint "。Clear Liu Mo says " card is controlled hundred and asked ": " blood stored in the liver, joint is muscle feeling pulse federation, gout this Liver Channel blood vessels, the wet fire of middle wind heat, delays between joint, swells and pain, and it is difficult to bend and stretch "。Systematic Compilation of Internal Classic is said: " foot faint the moon disease located in tendon, foot refers to greatly prop up, before internal malleolus bitterly, interior auxiliary pain。" so, clinically visible gouty arthritis most patients pain is waken up because of foot pain midnight, because of " row is in the moon also ", more than half starting in toe, and about 90% patient refers to be involved in the whole course of disease, sole of the foot toe, ankle, knee joint, refer to, the joint such as wrist is also predilection site。

In gout pathogenic process, midnight is in the majority, illustrates that disease is at blood, when there being obstruction of collaterals by blood stasis。Gout recurrent exerbation, prolonged does not heal, and meets the viewpoint of the traditional Chinese medical science " prolonged illness must the stasis of blood " " pathogen usually intruding into collateral in protracted disease "。Turbid damp stagnates in meridians joint, affects blood, and the blood vessels stasis of blood of a specified duration is stagnant, obstruction of collaterals by blood stasis。Turbid damp for a long time strongly fragrant enter inner heat-transformation, hinder ascending or descending movement of vital Qi, blood stasis, for a long time cause the stasis of blood；Turbid stasis of blood multiple abscess meridians, muscle, joint, numbness resistance internal organs passages through which vital energy circulates, may occur in which ankylosis deformity, purplish tongue, hesitant pulse etc., this is turbid stasis of blood knot and causes。Blood stasis is body pathological product under pathogenic factor effect, can act on human body as the cause of disease again。May occur in which any period in disease, especially common with middle and advanced stage, it is possible to run through gout and develop all the time, cause protracted inflammation。

In sum, " empty, turbid, hot, the stasis of blood " is the pathogenesis key that development occurs gout。Primary disease is with spleen caused by liver and kidney deficiency, insufficiency of vital energy and blood for this, and turbid damp, stagnant heat numbness resistance passages through which vital energy circulates, joint are mark, deficiency in origin and excess in superficiality。Accumulate in spleen caused by liver and kidney deficiency, turbid poison, damp and hot knot of fighting, turbid stasis of blood knot has run through whole disease all the time。Most of patient with gout, are all spleen kidney deficiencies, and unable blowdown is let out turbid, so, nourish spleen kidney, very crucial, the present invention is based on liver and kidney tonifying, promoting blood circulation to remove obstruction in the collateral, auxiliary clearing away heat-damp and promoting diuresis, blood stasis dispelling is dispelled turbid product, and this side is combined with again the medicine of combing Liver Channel, it is more suitable for, because gout starts to show effect in the thumb of foot more, Liver Channel follows capable position just herein, and both just agree with。The present invention not only to adopt promoting blood circulation and stopping pain relief of symptoms, dispel turbid (reduction blood uric acid) to purify the blood, let out turbid to take stopgap measures, and to adopt with tonifying speen and tonifying kidney, regulating liver and qi, blood-supplementing blood-nourishing to effect a permanent cure, prevent gout from recurring, fundamentally to reach to cure the purpose of gouty arthritis。

The compatibility foundation of Chinese medicine composition of the present invention:

We are with the Radix Rehmanniae Preparata of tonifying YIN of enriching blood for monarch drug；Radix Angelicae Sinensis, Radix Paeoniae Alba nourshing blood and promoting blood circulation, Rhizoma Chuanxiong, Radix Lamiophlomidis Rotatae are invigorated blood circulation promoting the circulation of blood, reducing swelling and alleviating pain, and Herba Leonuri promoting the circulation of blood is nourished blood, inducing diuresis to remove edema, Radix Cudraniae expelling wind and removing dampness, promoting blood circulation to restore menstrual flow, and the effect giving full play to nourishing blood and promoting blood circulation is ministerial drug。Radix Ginseng, Rhizoma Dioscoreae, Semen Euryales invigorating the spleen and benefiting QI, removing dampness are subsided a swelling, are reinforced the kidney；Colla cornus cervi, Ootheca Mantidis invigorating the liver and kidney, benefiting essence-blood, kidney tonifying is supporing yang；Carapax Trionycis, oyster yin-nourishing YANG hyperactivity suppressing, hard masses softening and resolving, bring down a fever except steaming, the Radix Rehmanniae, Radix Asparagi, Radix Stellariae nourishing YIN and clearing away heat, make clearing away heat-damp and promoting diuresis, uric acid resisting and non-impairment of YIN；Rhizoma Cyperi unclogs and readjusts irritability, menstruction regulating and pain relieving, is adjuvant drug, and Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making medicine。Full side qi and blood tonifying, negative and positive are double; two to be adjusted, and liver spleen kidney is taken into account, and plays tonifying speen and tonifying kidney, blood-supplementing blood-nourishing altogether, and merit turbid, Qingre Quyu pain relieving is let out in removing dampness。

The research of each herbal medicine in side:

Radix Rehmanniae: sweet-bitter flavor, cool in nature。Function cures mainly YIN nourishing, nourishes blood。Controlling fever due to yin deficiency, quench one's thirst, spit blood, epistaxis, metrorrhagia, menoxenia, frequent fetal movement, the moon hinders constipation。" herbal classic ": main folding falls exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fills out bone marrow, longue meat, makes soup and gathers except cold and heat, eliminating impediment。Survivor is especially good。" Japan hanako materia medica ": controlling palpitation with fear labor bad, cardiopulmonary damage, and spit blood, epistaxis, married woman's metrorrhagia bruise helps muscles and bones。Wang Haogu: main cardiopathia, feverish palms pain, stagnated QI flaccidity knit, drowsiness, the sole being heat and pain。" property of medicine opinion ": tonifying deficiency, warming the middle warmer and descending qi, promoting blood circulation, controls puerperal abdonimal pain, main unceasing hematemesis。" not Lu ": main man's five kinds of strain and seven kinds of impairment, woman's damaging the spleen and stomach, threatened abortion hematochezia, broken stagnant blood, hematuria, profit intestine and small intestine, remove dyspepsia in stomach, tonifying five ZANG-organs, internal injury is not enough, promoting blood circulation, physical strength profiting, profit knowledge。

Radix Rehmanniae Preparata: for the Preparation process product of Radix Rehmanniae。Sweet in the mouth, slightly warm in nature；Return liver, kidney channel；Function with cure mainly: YIN nourishing of enriching blood, benefit essence fill out marrow。For blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, dizziness, tinnitus, and chin is sent out early white。" pearl sac ": enrich blood greatly empty not enough, promoting blood circulation, physical strength profiting。" cure mainly secret want " cloud: it is with having five: kidney tonifying water is Kidney-Yin one also, and puerperal QI and blood two also, go umbilicus abdomen shoot three also, yin nourishing moves back sun four also, strengthens the source five of water also。" detailed outline ": fill out bone marrow, longue meat, promoting generation of vital essence and blood。Tonifying five ZANG-organs internal injury is not enough, promoting blood circulation, and profit knowledge, black beard and hair, man's five kinds of strain and seven kinds of impairment, woman's damaging the spleen and stomach threatened abortion, irregular menorrhea, tire produces all kinds of diseases and ailments。" Bencao Congxin ": kidney nourishing water, packing bone marrow, profit blood vessels, tonification is Kidney-Yin, hearing-improing and eyesight improving, hair color crow palpus。Again can tonifying spleen-yin, only chronic diarrhea。Controlling impairment caused by overstrain migratory arthralgia, yin deficiency is generated heat, dry cough phlegmatic cough, dyspnea with shortness of breath, and emptiness of the stomach feels hungry, and pox demonstrate,proves no pus of having a guilty conscience, and shin stock is ached after being ill, and puerperal, umbilicus abdomen suddenly ached, and sense card yin deficiency, lossless constipation, all kinds of dynamic blood, all hepatic and renal YIN deficiency, deficient all kinds of diseases and ailments, for the principal agent of strong water。

Concha Ostreae (calcined): salty, is slightly cold。Return liver, gallbladder, kidney channel。Effect: restrain astringent or styptic treatment for spontaneous sweating, relieving gastric hyperacidity to alleviate stomachache, tranquillization with heavy prescription, hard masses softening and resolving。There is YIN nourishing, nourish blood, tonifying five ZANG-organs, invigorate blood circulation, fill the effects such as flesh。" herbal classic ": main typhoid fever cold and heat, pyrexial malaria is voluminous, frightened gas of being enraged, and except arresting slow scrofula, woman's leukorrhagia is red in vain。Take bone strengthening joint for a long time。" not Lu ": except staying heat at joint Rong Wei, deficiency-heat is gone indefinite, stuffy sensation with restlessness；Hidroschesis, pained depressed, quench the thirst, except old blood。Puckery intestine and small intestine, only defecation, treat and let out essence, sore throat, cough, the lower painful abdominal mass heat of the heart side of body。" Haiyao Bencao, Oversea Materia Medica ": main man passes out semen, the weary damage of asthenia, the kidney invigorating healthy energy, only night sweat, goes dysphoria with smothery sensation, and cure the wound cold and heat expectorant, can take a tonic or nourishing food to build up one's health and calm the nerves, control child's infantile convulsion。" pearl sac ": soft mass in the abdomen。Controlling again leukorrhagia, pyrexial malaria, skin ulcer swells, for the agent of softening the hard mass astringent therapy。" detailed outline ": resolving phlegm and softening hard masses, removing damp-heat, only heart temper pain, under dysentery, reddish and whitish turbid urine, the hernia that disappears abdominal mass amasss block, wart disease tuberculosis。

Carapax Trionycis (processed): salty in the mouth, cold nature。Return liver, kidney channel。Function cures mainly: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except steaming。For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea, abdominal mass, chronic malaria malaria with splenomegaly。" herbal classic ": main trusted subordinate's lump in the abdomen heavily fortified point is long-pending, cold and heat, removes painful abdominal mass, polyp, the erosion of the vulva, hemorrhoid (core), evil meat。" not Lu ": treating pyrexial malaria, abdominal mass due to blood stasis, lumbago, children's coerces lower heavily fortified point。" property of medicine opinion ": host food, disease block, mass beside the umbilicus gas, cold abdominal mass, labor thin, the therapeutic method to keep the adverse QI flowing downwards, except bone is warm, consumptive fever between joint, solid is jammed。Control married woman leak down the five colors weakness and emaciation person。" Japan hanako materia medica ": gas of dehematizing, broken crux, stagnant blood, induced abortion, the skin ulcer that disappears swells and flutters damage blood stasis, malaria, acute appendicitis。" Amplification on Materia Medica addendum ": nourishing YIN QI invigorating。" Elementary Medicine ": main malaria with general debility, old malaria, woman's amenorrhea, infant dysentery。" Jiangxi Chinese medicine ": control osteomalacia。

Radix Lamiophlomidis Rotatae: bitter in the mouth, cold nature。Slightly poisonous。Function cures mainly: blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain。For traumatic injury, fracture, lumbar strain。" Traditional Chinese Medicine in Sichuan will ": blood circulation promoting competent silt, pain relieving, circulation of qi promoting, detumescence, reunion of fractured tendons and bones。Control and get injured by a fall muscles and bones and diseases such as frustrating gas of spraining one's back。" Qinghai-Tibet Platean medicine illustrated handbook ": mend marrow, hemostasis。Flowing yellow fluid after controlling edema, yellow fluid, spongy bone inflammation are amassed in joint。

Ootheca Mantidis: sweet in the mouth, salty, property is put down。Return liver, kidney channel。Function cures mainly: supplementing the kidney to control the nocturnal, reducing urination, only turbid。For emission and spermatorrhea, enuresis frequent micturition, urine nebulousurine。" herbal classic ": main damaging the spleen and stomach, hernia abdominal mass, impotence, the raw son of benefit essence。Woman's blood closes lumbago, logical five types of stranguria, diuresis water channel。" not Lu ": treat man deficient, five hide feeble QI, dream consumption of essence, incontinence of urine。" property of medicine opinion ": main man's renal failure leakage essence, essence is from going out, and person can stop it to suffer from cold caused by deficiency。Only normal urination, cannon order heat, hollow food it。Empty and normal urination, adds and uses it。Amplification on Canon of Materia Medica: control urine nebulousurine。" beautiful Chinese catalpa medicine solution ": control foul leukorrhea dripping, otalgia, sore throat, abdominal mass hernia, a fishbone or other bone caught in the throat。

Radix Stellariae: sweet in the mouth, cold nature。Return liver, stomach warp。Function cures mainly: clearind deficient heat, dispelling fever with infantile malnutrition。For fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, children's's infantile malnutrition with fever。" Bencao Jingshu ": control consumptive fever hectic fever due to YIN-deficiency。" Bencao Congxin ": control the hot hectic fever due to YIN-deficiency of asthenia flesh, malaria with general debility heat goes out from marrow, the thin heat of children's's five kinds of child malnutrition。" medical center bun is wanted ": hard kidney water, flat fire mutually。" book on Chinese herbal medicine asks former ": lung heat clearing, stomach, spleen, kidney-heat, holding concurrently can removing heat from blood。Treating disorders in five ZANG-organs is deficient, skin consumptive fever, the tired pain of hectic fever due to YIN-deficiency, arthralgia chiefly caused by damp pathogen contracture。" Chinese Herbal Medicine in Xinjiang handbook ": clearing away heat and cooling blood。Control pulmonary tuberculosis hectic fever。

Semen Euryales (parched): sweet in the mouth, puckery, property is put down。Return spleen, kidney channel。Function cures mainly: supplementing the kidney to control the nocturnal, tonifying spleen and stopping diarrhea, damp eliminating leukorrhagia stopping。For emission, enuresis frequent micturition, insufficiency of the spleen chronic diarrhea, nebulousurine, leukorrhagia。" herbal classic ": main arthralgia chiefly caused by damp pathogen spinal column gonalgia, invigorating middle warmer removes sudden and violent disease, benefit vital essence, Qiang Zhi, makes normal hearing and eyesight。" Japan hanako materia medica ": appetizing helps gas。" detailed outline ": quench the thirst kidney tonifying。Control incontinence of urine, seminal emission, nebulousurine, leukorrhagia。" Bencao Congxin ": spleen reinforcing is reinforced the kidney, helps gas arresting seminal emission。Control emission, solve summer-heat alcoholism, treat foul leukorrhea and have loose bowels, incontinence of urine。

Rhizoma Cyperi (processed with vinegar): acrid in the mouth, micro-hardship, property are micro-sweet is flat。Return liver, spleen, tri-jiao channel。Function cures mainly: promoting QI circulation for relieving depression, menstruction regulating and pain relieving。For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea。" not Lu ": main fill fur except feverish sensation in the chest, clothes profit people, QI invigorating, long hair eyebrow for a long time。Tang Materia Medica: the big therapeutic method to keep the adverse QI flowing downwards, except breast heat in the abdomen。Li Gao: control all gas, and cholera is vomited and diarrhoea and is suffered from abdominal pain, kidney qi, bladder is cold, removing stagnancy of indigested food and making QI downward。Materia Medica of Decoction: control metrorrhagia。" the southern regions of the Yunnan Province book on Chinese herbal medicine ": adjust the gas in blood, dissipating depression of QI, alleviating distention in middle-JIAO, help digestion, anti-nausea。" detailed outline ": dissipating the cold epidemic disease of seasonal epidemic pathogens, profit three is burnt, solves six kinds of stagnation-syndromes, and the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spit blood, hematochezia, hematuria, married woman's bleeding not during menses, the moon waits uncomfortable, all kinds of diseases and ailments in puerperal before tire。

Radix Asparagi: sweet in the mouth, hardship, cold in nature。Return lung, kidney channel。Function cures mainly: nourishing YIN to relieve dryness, and lung heat clearing is promoted the production of body fluid。For dryness of the lung dry cough, pertussis expectorant sticks, dry throat and mouth, dryness of the intestine constipation。Compendium of Material Medica load Radix Asparagi " cooks it, make us human body and slide damp fair and clear, except all bad odor are unclean with it disease "。The property of Radix Asparagi bitter cold more very, tonifying the lung, stomach the moon be better than Radix Ophiopogonis, cough up phlegm unfavorable person to cough, and holding concurrently can eliminating phlegm and stopping cough, moreover it is possible to enter kidney channel with tonifying kidney-yin, kidney fire drops, the disease of deficiency of kidney-YIN, hyperactivity of fire caused by deficiency of YIN can be controlled。

Radix Ginseng: sweet in the mouth, micro-hardship is warm in nature, flat。Return spleen, lung meridian, heart channel。Effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, calms the nerves。" herbal classic ": main tonifying five ZANG-organs, peace spirit, spasmolytic is throbbed with fear, evil removing gas, improving eyesight, happy Fructus Alpiniae Oxyphyllae。" not Lu ": treat intestinal cold in the stomach, trusted subordinate's drum pain, costa sternales fullness due to adverse ascending of QI, cholera be told inverse, in tune, only quenches one's thirst, promoting blood circulation, and broken heavily fortified point is long-pending, makes us not forgetting。" pearl sac ": nourish blood, mends gastric qi, eliminating heart-fire。" the southern regions of the Yunnan Province book on Chinese herbal medicine ": control negative and positive deficiency, insufficiency of lung-QI。" book on Chinese herbal medicine covers bamboo fish trap ": " relieving asthma and cough, unobstructed blood vessels, rush down YIN-fire, nourishes Yuanyang。" detailed outline ": " controlling man's all deficiency syndrome of woman, generate heat spontaneous perspiration, dizziness and headache, and food, malaria, sliding chronic dysentery of rushing down, frequent micturition are told in regurgitation, drench drop, overstrain internal injury, apoplexy, heatstroke, flaccidity syndrome and arthralgia syndrome, spit blood, hemoptysis, hematochezia, stranguria with blood, metrorrhagia, all diseases in puerperal before tire。

Radix Angelicae Sinensis: sweet in the mouth, pungent, warm in nature。Return liver, the heart, spleen channel。Function cures mainly: replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation。For blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores。Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow。For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down。" herbal classic ": main cough with dyspnea, pyrexial malaria cold and heat are washed in skin, and married woman is leaked down, sterilization, all malignant boil infections incised wounds, boil drink。" not Lu ": warming middle-JIAO to relieve pain, except plug, middle puerperal tetanus, no sweating, arthralgia chiefly caused by damp pathogen in visitor's blood, attacked by pestiferous factors be courteous, cold caused by deficiency, mends five Tibetan, granulation promoting meat。" Japan hanako materia medica ": control a wind cutting, all blood, mend all labor, broken stagnant blood, support fresh blood and main addiction。Wang Haogu: main flaccidity drowsiness, the sole being heat and pain。Chong channel is disease, QI rising in reverse order pain in the abdomen；Dai channel is disease, stomachache, and waist is broad as sat in water。" book on Chinese herbal medicine cover bamboo fish trap ": by traumatic injury blood clotting, and hematodiarrhoea draw together pain stagnant live in the intestines and stomach。" detailed outline ": " control headache, all pains of trusted subordinate, intestine moistening stomach muscles and bones skin。Control carbuncle, evacuation of pus pain relieving, and blood to enrich blood。

Radix Cudraniae: lightly seasoned micro-hardship, cool in nature。Function cures mainly: expelling wind and removing dampness, promoting blood circulation to restore menstrual flow。Dispelling the wind and dampness pathogens arthralgia, jaundice, stranguria with turbid discharge, distention of the abdomen caused by various parasites, amenorrhea, impairment caused by overstrain hemoptysis, traumatic injury, furuncle carbuncle。" the SHENGCAO property of medicine is standby to be wanted ": controlling wine top, disappear distention of the abdomen caused by various parasites；Infusing drugs in wine dispels the wind。" book on Chinese herbal medicine asks former ": strengthening bone and muscle, invigorates blood circulation, and manages traumatic injury。" Nanning City's medicine will ": blood stimulates the menstrual flow, and controls stranguria with turbid discharge, goes that the many years ago stasis of blood is long-pending, calculus。" east, Fujian book on Chinese herbal medicine ": invigorating spleen and reinforcing stomach, relaxing muscles and tendons and activating QI and blood in the collateral, wind-damp dispelling, blood stasis removing blood。Control lumbago, arthralgia, asthenia general edema with yellowish skin, diarrhea due to hypofunction of the spleen。Guangzhou army " conventional Chinese herbal medicine handbook ": cool the blood dissipate blood stasis。Control amenorrhea。" Guangxi practicality Chinese herbal medicine newly selects ": heat clearing and blood circulation promoting, eliminating phlegm and stopping cough, controls impairment caused by overstrain hemoptysis。" Fujian Chinese herbal medicine ": clearing away heat-damp and promoting diuresis。Damp-heat arthralgia, furuncle carbuncle。

Colla cornus cervi: salty in the mouth, warm in nature。Enter liver, kidney channel。Function cures mainly: qi-restoratives, supporing yang。Control insufficiency of kidney-YANG, ache of the spinal column, Deficiency and coldness of spleen and stomach, vomiting, anorexia and loose stool, deficiency-cold of uterus, bleeding not during menses。" book on Chinese herbal medicine covers bamboo fish trap ": curing mainly same Colla cornus cervi, effect is slightly slow。" Elementary Medicine ": control five kinds of strain and seven kinds of impairment and win thin, tonify Qi of the kidney, nocturnal control and yang nourishing, bone strengthening marrow, control nocturnal emission。" book on Chinese herbal medicine converges and says ": astringent therapy dysentery relieving, goes married woman leucorrhea。" herbal classic is met former ": controlling Deficiency and coldness of spleen and stomach, anorexia and loose stool, regurgitation is vomitted。" Traditional Chinese Medicine in Sichuan will ": invigorating middle warmer benefit blood, pain relieving is antiabortive。Controlling injured, variola does not rise, furuncle, sore swollen toxin。

Herba Leonuri: bitter in the mouth, pungent, cold nature。Return liver, pericardium channel。Function cures mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema。For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria；Acute nephritis edema。" herbal classic ": main urticaria is itched。Amplification on Canon of Materia Medica: all diseases in puerperal before managing property, promoting the circulation of blood is nourished blood；Cream clothes are made in difficult labour。" book on Chinese herbal medicine covers bamboo fish trap ": remove stillborn fetus, peaceful tire, clots absorbing blood, tissue regeneration promoting blood。Control infantile emaciation。" detailed outline ": invigorate blood circulation, removing blood stasis, regulating menstruation, removing toxic substances。Control vaginal bleeding during pregnancy dystocia, placenta retention, bruise, blood wind, blood pain, metrorrhagia and metrostaxis, hematuria, rush down blood, dysentery, infantile malnutrition, haemorrhoids, beat and flutter interior damage blood stasis, stool, urinary obstruction。" book on Chinese herbal medicine asks former ": heat clearing away, removing heat from blood, removing toxic substances。

Rhizoma Chuanxiong: acrid in the mouth, warm in nature。Return liver, gallbladder, pericardium channel。Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping。For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia。" herbal classic ": main apoplexy enters brain headache, arthralgia due to cold, clonic spasm of the muscle emergency, and gold wound, married woman's blood closes loss of fecundity。" not Lu ": except cold dynamic in brain, on face, urticaria goes, order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, trusted subordinate's heavily fortified point pain, attacked by pestiferous factors, soldier is anxious to swell and ache, side of body wind bitterly, warming middle-JIAO endogenous cold。" Japan hanako materia medica ": control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjust many arteries and veins, broken knot stagnated blood, support fresh blood, put on flesh, serious epistaxis, to spit blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, scrofula wart is gone to live in the household of one's in-laws on getting married, skin ulcer scabies, and evacuation of pus repercussive blood。" medicine origin ": enrich blood, controls headache due to deficiency of blood。Wang Haogu: searching irritability, tonifying liver blood, profit liver is dry, mends wind empty。" detailed outline ": dampness, antidiarrheal dysentery, activating QI to alleviate the depression。

The Radix Paeoniae Alba: nature and flavor are bitter is cool。Enter liver, spleen channel。Effect clots absorbing, pain relieving, removing heat from blood, detumescence。Controlling the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle。" herbal classic ": main pathogen is suffered from abdominal pain, except arthralgia due to stagnation of blood, broken heavily fortified point is long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating。" not Lu ": clear and coherent blood vessels, in slow, dispelling malignant blood, expelling extravasated blood, anhydrate gas, profit bladder intestine and small intestine, subduing inflammation, time row cold and heat, attacked by pestiferous factors is suffered from abdominal pain, lumbago。" the southern regions of the Yunnan Province book on Chinese herbal medicine ": purgation of spleen excess fire, sending down the abnormal ascending QI, promoting the circulation of blood, removing blood stasis with potent drugs, dissipates clot, and only stomachache, moves back heat in blood, attack ulcerative carbuncle, control mange。

Rhizoma Dioscoreae: sweet in the mouth, property is put down。Return spleen, lung, kidney channel。Function cures mainly: spleen reinforcing nourishing the stomach, and promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission。For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat are quenched one's thirst。Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating。For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia。" herbal classic ": main damaging the spleen and stomach, qi-restoratives, except cold and heat pathogen, invigorating the spleen and replenishing QI power, longue meat, take normal hearing and eyesight for a long time。" property of medicine opinion ": mend five kinds of strain and seven kinds of impairment, remove cold wind, only lumbago, relieving palpitation god, reinforcing the heart QI-insufficiency, suffer from human body weakness with emaciation, add and use it。" Japan hanako materia medica ": helping the five internal organs, bone and muscle strengthening, long will is calmed the nerves, it is forgetful that master lets out essence。" typhoid fever accumulate want ": tonifying for the deficiency, clearind deficient heat。" detailed outline ": kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery, reduce phlegm saliva, moistens fur。

Radix Glycyrrhizae: sweet in the mouth, property is put down。Enter spleen, stomach, lung meridian。Function cures mainly: with middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription。Processing use, control weakness of the spleen and stomach, lack of appetite, loose stool of suffering from abdominal pain, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, infantile convulsion；Raw use, controls laryngopharynx swelling and pain, peptic ulcer, ulcer sores, solves poison of drug and alimentary toxicosis。" herbal classic ": main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound swells, removing toxic substances。" not Lu ": warming the middle warmer and descending qi, stuffy sensation with restlessness be losed heart, and hinders dirty cough, quenches the thirst, qualcomm meridian, profit vim and vigour, solves hundred poison of drug。" property of medicine opinion ": cold type of pain in main abdomen, controls infantile convulsion, except distention and fullness in the abdomen；Tonification the five internal organs；Make all poison of drug；Support kidney qi internal injury, make us cloudy (no) flaccidity；Housewife's human blood drop lumbago；Empty and frequent fever；Add and use it。" Japan hanako materia medica ": peace soul determines soul。Mending five kinds of strain and seven kinds of impairment, all are deficient, palpitation with fear, unhappy, forgetful。Logical nine orifices, sharp hundred arteries and veins, benefit intensive culture gas, strengthening bone and muscle, solve cold and hot。" pearl sac ": enrich blood, nourishing the stomach。

Detailed description of the invention

Below in conjunction with embodiment, the present invention is further described。

Embodiment 1: the preparation of powder or pill

Each crude drug is weighed: 50 parts of Radix Rehmanniae Preparata, Radix Rehmanniae 50 parts, Colla cornus cervi 24 parts, Herba Leonuri 50 parts, Radix Cudraniae 24 parts, Radix Lamiophlomidis Rotatae 24 parts, Rhizoma Dioscoreae 24 parts, Semen Euryales (parched) 24 parts, Radix Ginseng 20 parts, Carapax Trionycis (processed) 12 parts, Concha Ostreae (calcined) 10 parts, Ootheca Mantidis 10 parts, Radix Angelicae Sinensis 24 parts, the Radix Paeoniae Alba 24 parts, Rhizoma Cyperi (processed with vinegar) 24 parts, Radix Asparagi 24 parts, Rhizoma Chuanxiong 24 parts, Radix Stellariae 4 parts, 6 parts of Radix Glycyrrhizae by following weight；After above-mentioned crude drug co-grinding except Colla cornus cervi, cross 80 mesh sieves, add the mixing of Colla cornus cervi comminuted powder, to obtain final product。

Embodiment 2: the preparation of granule

(1) each raw material is weighed by following weight: Radix Rehmanniae Preparata 120g, Radix Rehmanniae 120g, Colla cornus cervi 80g, Herba Leonuri 120g, Radix Cudraniae 80g, Radix Lamiophlomidis Rotatae 80g, Rhizoma Dioscoreae 80g, Semen Euryales (parched) 80g, Radix Ginseng 60g, Carapax Trionycis (processed) 40g, Concha Ostreae (calcined) 32g, Ootheca Mantidis 32g, Radix Angelicae Sinensis 80g, Radix Paeoniae Alba 80g, Rhizoma Cyperi (processed with vinegar) 80g, Radix Asparagi 80g, Rhizoma Chuanxiong 80g, Radix Stellariae 16g, Radix Glycyrrhizae 20g；

(2) Colla cornus cervi, Rhizoma Dioscoreae, Semen Euryales (parched), Rhizoma Cyperi (processed with vinegar), Radix Asparagi, Rhizoma Chuanxiong, Radix Ginseng, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Carapax Trionycis (processed) are pulverized respectively, standby；

(3) by Radix Rehmanniae Preparata, Radix Rehmanniae, Herba Leonuri, Radix Cudraniae, Radix Lamiophlomidis Rotatae, Concha Ostreae (calcined), Ootheca Mantidis, Radix Stellariae and Radix Glycyrrhizae 10 times amount water extraction twice, each 1.5 hours, filtering, be evaporated to thick paste, drying under reduced pressure, pulverize, get dry extract powder, standby；

(4) by product mix homogeneously obtained to step (2) and (3), appropriate dextrin is added, stevioside, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, it is distributed into 100 bags, 10g/ bag。

Embodiment 3: the preparation of granule

(1) each raw material is weighed by following weight: Radix Rehmanniae Preparata 120g, Radix Rehmanniae 120g, Colla cornus cervi 75g, Herba Leonuri 120g, Radix Cudraniae 75g, Radix Lamiophlomidis Rotatae 75g, Rhizoma Dioscoreae 75g, Semen Euryales (parched) 75g, Radix Ginseng 75g, Carapax Trionycis (processed) 45g, Concha Ostreae (calcined) 30g, Ootheca Mantidis 30g, Radix Angelicae Sinensis 75g, Radix Paeoniae Alba 75g, Rhizoma Cyperi (processed with vinegar) 75g, Radix Asparagi 75g, Rhizoma Chuanxiong 75g, Radix Stellariae 24g, Radix Glycyrrhizae 18g；

(3) by Radix Rehmanniae Preparata, Radix Rehmanniae, Herba Leonuri, Radix Cudraniae, Radix Lamiophlomidis Rotatae, Concha Ostreae (calcined), Ootheca Mantidis, Radix Stellariae and Radix Glycyrrhizae 8 times amount water extraction twice, each 2 hours, filtering, be evaporated to thick paste, drying under reduced pressure, pulverize, get dry extract powder, standby；

(4) by product mix homogeneously obtained to step (2) and (3), add appropriate amount of starch and cane sugar powder, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, it is distributed into 65 bags, 15g/ bag。

Embodiment 4: clinical research is tested

One, clinical data

Choose and connect subject patient with gout in August, 2015 in my institute 45 in January, 2013, the all patients of this group all meet the gout diagnostic criteria that turbid damp blood stasis blocking type in " tcm syndrome diagnosis and treatment standard " implements diagnosis and Americanism damp disease association proposes, wherein there are 40 male, 5 women, mean age is (43.7 ± 1.4) year, average course of disease is (9.3 ± 2.5) year, wherein 33 patient's courses of disease are within 5 years, 10 patient's courses of disease are within 6～10 years, and 2 patient's courses of disease are more than 10 years；12 patients are acute gouty arthritis, and 26 patients show effect the catabasis for gout, and 5 patients are tophus, and 2 are called other。

Two, Therapeutic Method

Granule prepared by the embodiment of the present invention 2。Each take 1 bag, every day 3 bags。

Three, the standard of curative effect evaluation

According to clinical symptom disappearance such as " tcm syndrome diagnosis and treatment standard " efficacy assessment standard, patient articular is hot, swollen, red, pains, articular cavity synovial bursa liquid microscopy display aciculiform urate crystal disappears, and blood uric acid recovers normal level for curing；The clinical symptoms such as patient articular is hot, swollen, red, pain are alleviated to some extent, and serum uric acid level reduces, and local joint skin pruritus, desquamation symptom are eased as taking a turn for the better；Patients symptomatic is not eased, and its blood uric acid is not healed also without being reduced to。Total effective rate=cure rate+improvement rate。

Four, statistical procedures

Carrying out statistical procedures by SPSS13.0 software, compare employing paired t-test with before and after group treatment, measurement data represents with (x ± s), and P < 0.05 represents that diversity is comparatively obvious, has statistical significance。

Five, therapeutic outcome

1, clinical efficacy contrast, result is in Table 1。

。

In 45 selected example patients, 30 examples of wherein fully recovering, account for 66.7%；Effective 14 examples, account for 31.1%；Invalid 1 example, accounts for 2.2%, and total effective rate is 97.78%。

2, the serum Uric Acid Concentration before and after contrast patient treatment

Before treatment, patient's serum Uric Acid Concentration average out to (683.148 ± 93.268) μm ol L^-1, after treatment, patient's serum Uric Acid Concentration average out to (428.647 ± 78.224) μm ol L^-1, its diversity contrasts, and difference has statistical significance (P < 0.05), and result is in Table 2。

。

Embodiment 5: model case

1. Zhang, male, 58 years old, first visit in July, 2013。Extremities joint swells and ache 7 years, left swelling and pain in knee, and edema of pair of lower extremities is examined more than the moon, looks into the both hands multiple tophus of foot, and such as Fructus Vitis viniferae sample size, red and swollen hotness, tenderness is obvious, and left knee joint redness hotness, tenderness is obvious。Color ultrasound shows right kidney, prostate Calculus, and double; two lower limb many gouts crystallizations are formed and blood vessel embolism x-ray shows both hands peri position, and the multiple tophus of metacarpophalangeal joints bone erosion destroy。Stool is viscous usually, and matter soft stool is half congealed；It is blacking up that One's face was like wax；Red tongue, sublingual vein dark brown, yellow and greasy fur, wiry and frequent pulse。Tcm diagnosis: the damp and hot blockage of phlegm and blood stasis card of turbid numbness, asthenia of both the spleen and kidney。Western medicine diagnose: gouty arthritis gouty nephropathy。Plan side: Radix Rehmanniae Preparata 40g, Radix Rehmanniae 25g, Colla cornus cervi 20g, Herba Leonuri 40g, Radix Cudraniae 20g, Radix Lamiophlomidis Rotatae 25g, Rhizoma Dioscoreae 25g, Semen Euryales (parched) 12g, Radix Ginseng 10g, Carapax Trionycis (processed) 15g, Concha Ostreae (calcined) 10g, Ootheca Mantidis 10g, Radix Angelicae Sinensis 20g, Radix Paeoniae Alba 12g, Rhizoma Cyperi (processed with vinegar) 12g, Radix Asparagi 12g, Rhizoma Chuanxiong 12g, Radix Stellariae 4g, Radix Glycyrrhizae 6g。7 doses, every day 1 dose, sooner or later decoction being taken warmly。Advise and do not bear a heavy burden, lifting affected limb, temperance for food and drink, anti-infection。Taking 5 doses, brothers and left knee joint congestion and swelling pain substantially alleviate, and energy Go to ground activity, standing for a long time still swells and ache。Two examine, 10 doses of following the services of defence, and suitable lifting affected limb is taken exercise。Three examine, and extremity tuberosity redness substantially alleviates, relieving swelling and pain of joints, and double; two lower limbs edema disappear, and can walk voluntarily, defence's following the service 20 doses, and tuberosity swells and ache and disappears, and freely, check indices all normally, can normal operation in walking。

2. Lee, female, 76 years old, retired employees, in April, 2014 was weak because of the whole body, and soreness of waist pain, right chronic foot pain carrys out undergraduate course out-patient treatment。Disease sees that the whole body is weak, right chronic foot pain, poor appetite, and urine color is yellowish, has foam, oliguria, defecate just soft in urine, 1 time on the 1st～2, and night sleeps not good enough。Body of the tongue is dull, and tongue is white, stringy and rolling pulse。Previously gouty arthritis medical history 8 years。Lab testing: routine urinalysis: urine protein ++, occult blood+, erythrocyte 5～6/HP under mirror, serum creatinine 392mmol/L, blood urea nitrogen 24.0mmol/L, 676 μm of ol/L of uric acid；Diagnosis is: chronic renal insufficiency (stage of exhaustion), gouty nephropathy, hyperuricemia。Chinese medical discrimination is that asthenia of both the spleen and kidney is held concurrently phlegm-damp blood stasis。Treatment adopts the Chinese medicine granules of the embodiment of the present invention 2。After 7 days, weak, soreness of waist pain shape takes a turn for the better, and right chronic foot pain substantially alleviates, and checks kidney merit: serum creatinine 130mmol/L, 492 μm of ol/L of blood uric acid, blood urea nitrogen 10.2mmol/L, routine urinalysis is without significant change。Advise that patient is continuous takes 7 doses, patient's kidney merit: serum creatinine 115mmol/L, uric acid 350mol/L, blood urea nitrogen 8.8mmol/L, routine urinalysis show urine protein+, occult blood+, erythrocyte 4～5/HP under mirror。Patient continues to take Chinese medicine decoction so far, and renal function and uric acid are all down to normal range。

Claims

1. the Chinese medicine composition treating gouty arthritis,chronic, it is characterised in that be made up of each crude drug of following weight portion: Radix Rehmanniae Preparata 25-40 part, Radix Rehmanniae 25-40 part, Colla cornus cervi 12-25 part, Herba Leonuri 25-40 part, Radix Cudraniae 12-25 part, Radix Lamiophlomidis Rotatae 12-25 part, Rhizoma Dioscoreae 12-25 part, Semen Euryales (parched) 12-25 part, Radix Ginseng 10-25 part, Carapax Trionycis (processed) 6-15 part, Concha Ostreae (calcined) 5-10 part, Ootheca Mantidis 5-10 part, Radix Angelicae Sinensis 12-25 part, Radix Paeoniae Alba 12-25 part, Rhizoma Cyperi (processed with vinegar) 12-25 part, Radix Asparagi 12-25 part, Rhizoma Chuanxiong 12-25 part, Radix Stellariae 2-8 part, Radix Glycyrrhizae 3-6 part。

2. the compositions described in claim 1, it is characterized in that, the weight portion of each crude drug is: 30 parts of Radix Rehmanniae Preparata, Radix Rehmanniae 30 parts, Colla cornus cervi 20 parts, Herba Leonuri 30 parts, Radix Cudraniae 20 parts, Radix Lamiophlomidis Rotatae 20 parts, Rhizoma Dioscoreae 20 parts, Semen Euryales (parched) 20 parts, Radix Ginseng 15 parts, Carapax Trionycis (processed) 10 parts, Concha Ostreae (calcined) 8 parts, Ootheca Mantidis 8 parts, Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 20 parts, Rhizoma Cyperi (processed with vinegar) 20 parts, Radix Asparagi 20 parts, Rhizoma Chuanxiong 20 parts, Radix Stellariae 4 parts, 5 parts of Radix Glycyrrhizae。

3. the compositions described in claim 1 or 2, it is characterised in that: prepare into preparation suitable clinically according to Chinese medicine preparation。

4. the compositions described in claim 3, it is characterised in that: described preparation includes capsule, pill, powder, granule, tablet, oral liquid or drop pill。

5. the preparation method of the compositions described in a claim 1 or 2, it is characterised in that: weigh each crude drug by described weight portion；Each crude drug is pulverized, sieves, add the adjuvant needed for preparations shaping or excipient, prepare into capsule, tablet or pill。

6. the preparation method of the compositions described in a claim 1 or 2, it is characterised in that comprise the following steps:

(1) each crude drug is weighed by described weight portion；

(3) by Radix Rehmanniae Preparata, Radix Rehmanniae, Herba Leonuri, Radix Cudraniae, Radix Lamiophlomidis Rotatae, Concha Ostreae (calcined), Ootheca Mantidis, Radix Stellariae and Radix Glycyrrhizae water extraction twice, each 0.5-3 hour, filtering, be evaporated to thick paste, drying under reduced pressure, pulverizing gets dry extract, standby；

(4) by product mix homogeneously obtained to step (2) and (3), add pharmaceutical preparation auxiliary materials and mixing and make intermediate formulations, make finished dosage form then through preparations shaping technique。

7. the application in preparation treatment gouty arthritis,chronic medicine of the compositions described in claim 1 or 2。