CN114652783A - Medicine for treating traumatic synovitis of knee joint - Google Patents

Medicine for treating traumatic synovitis of knee joint Download PDF

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Publication number
CN114652783A
CN114652783A CN202011644976.4A CN202011644976A CN114652783A CN 114652783 A CN114652783 A CN 114652783A CN 202011644976 A CN202011644976 A CN 202011644976A CN 114652783 A CN114652783 A CN 114652783A
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China
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medicine
synovitis
pain
treating
traumatic
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CN202011644976.4A
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闫家乐
闫举
闫家旭
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Individual
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The invention discloses a medicine for treating traumatic synovitis of knee joints and a preparation method thereof, and relates to an over-the-counter medicine for treating joint diseases of limbs. Is prepared from 7 Chinese-medicinal materials including impatiens balsamina, red sage root, Chinese angelica root, etc through immersing them in edible spirit brewed at 52-60 deg. C, removing dregs, and applying it on the affected part. The traditional Chinese medicine has mild medicine property, can expel wind and relieve pain, promote blood circulation and reduce swelling, and has quick response and short treatment course. Traumatic synovitis is caused by local sprain, external force injury, chronic strain and other meridian injury, unsmooth blood circulation, local stagnation, malnutrition of muscles and tendons, and invasion of wind-cold-dampness-heat evil in a deficient way, so that the obstruction of the veins is aggravated. The medicine is used for assisting the oral medicine in dissipating blood stasis, promoting tissue regeneration, relieving swelling and alleviating pain in the acute stage of synovitis; in the chronic stage, the medicine can dispel wind and dry dampness, and strengthen muscles and bones. The traditional Chinese medicine composition is frequently applied to patients to avoid repeated onset of synovitis and restore normal functions of joints, and solves the problem that no specific external medicine is available for treating knee joint traumatic synovitis at present. The product also has significant curative effects on rheumatic arthritis, tenosynovitis of fingers, traumatic injury and the like.

Description

Medicine for treating traumatic synovitis of knee joint
The invention relates to a medicament for treating knee joint traumatic synovitis and a preparation method thereof, belonging to the technical field of diseases of arthralgia of limbs, in particular to a medicament for treating knee joint traumatic synovitis and prepared by taking pure Chinese medicaments as raw materials, which is externally applied to an affected part.
The synovial membrane is the inner layer of the joint capsule, is a thin and soft connective tissue membrane, can secrete synovial fluid to lubricate the joint, and can supply nutrients and exclusive metabolic waste to the meniscus and the articular cartilage. Synovitis in a broad sense refers to a disease of the joints in which synovial inflammation changes due to any cause. The common causes include trauma, infection, tuberculosis, rheumatic diseases, degenerative joint diseases, etc. Traumatic synovitis is a synovial, non-infectious inflammatory response that is caused after joint injury, most commonly found in the knee joint.
The clinical characteristics of the traumatic synovitis of the knee joint are that the knee joint has a history of knee injury, the knee joint is swollen, pain is aggravated during passive flexion and extension movement, the knee flexion activity is limited, the local skin temperature can be increased, and effusion generally appears. Chronic knee joint is usually from acute to persistent knee joint swelling, aggravation after fatigue, difficulty in squatting, pain in going up and down stairs, and atrophy of quadriceps femoris and joint instability. The joints are pivot joints of life, are painful, and repeatedly attack, which can affect the daily life of patients and even lose walking ability.
According to the traditional Chinese medicine, traumatic synovitis of knee joints is blood stasis arthralgia which is caused by meridian injury, unsmooth blood circulation, local retention, malnutrition of muscles and tendons, low resistance to exogenous pathogenic factors, invasion of pathogenic wind-cold damp-heat due to deficiency, aggravation of meridian obstruction and arthralgia syndrome. The pain of the affected part is obvious and aggravated in cold and heat and rainy days. Current non-steroidal anti-inflammatory drugs for the treatment of synovitis can control inflammation, relieve pain, but can lead to the risk of gastrointestinal bleeding and perforation. Some Chinese patent medicines have some effects on treating the synovitis, but have the effect of damaging liver and kidney. The external medicine has poor curative effect mostly, has stimulation effect on skin and has the treatment difficulty of radically treating chronic synovitis.
The invention aims to provide a medicament for treating traumatic synovitis of knee joints, which is externally applied to patients and is applied to affected parts without adverse reactions. The medicine has the effects of dispelling pathogenic wind, relieving pain, promoting blood circulation and relieving swelling. The synovitis can help the oral medicine to dissipate blood stasis and promote tissue regeneration, relieve swelling and pain in the acute stage, dispel wind and remove dampness in the chronic stage, strengthen muscles and bones, avoid repeated onset of the synovitis and recover the normal functions of joints. It also has obvious curative effect on traumatic injury, rheumatic osteopathy, etc.
The technical scheme of the invention is realized in the following mode.
A medicament for treating knee joint traumatic synovitis is a medicament prepared from the following traditional Chinese medicines as raw materials: 20 g of impatiens balsamina, 10 g of salvia miltiorrhiza, 10 g of angelica, 10 g of prepared frankincense, 10 g of prepared myrrh, 10 g of medicinal cyathula root and 10 g of obscured homalomena rhizome.
The prescription consists of 7 traditional Chinese medicines according to a proportion, the weight of the traditional Chinese medicine is 80 g, and the traditional Chinese medicine is externally used and has no toxic or side effect.
The medicines are soaked in 52-60 degrees of edible white spirit brewed by 500 g of pure grains according to the proportion, namely the relative dose, of the medicines, the mixture is placed in a glass container, the glass container is sealed for 20-30 days, dregs are removed, the liquid is taken out for external use and is smeared on an affected part for 2-5 times per day.
The prescription is a wind-dispelling and pain-relieving agent. For the treatment of traumatic synovitis. Is very troublesome clinically. When used for the treatment of the traditional Chinese medicine, the single wind-dispelling and dampness-removing medicine has a very small effect, the main effects of promoting blood circulation and removing blood stasis are achieved, and the auxiliary effects of the wind-dispelling and dampness-removing medicine are very good. In the formula, the impatiens balsamina is sweet and warm, has the functions of dispelling wind, promoting blood circulation to arrest pain, detoxifying and reducing swelling, can treat rheumatism, waist and knee pain, traumatic injury, carbuncle, furuncle and the like, and is a main medicine of the formula. The auxiliary main medicines of the salvia miltiorrhiza, the angelica, the prepared frankincense, the prepared myrrh and the radix cyathulae have the functions of promoting blood circulation and removing blood stasis, dredging collaterals and relieving pain, and reducing swelling and promoting granulation. Has obvious effects on persistent swelling, difficult squatting, limited joint movement, local skin temperature rise and the like of traumatic synovitis. Qiannianjian is most suitable for treating rheumatism, arthralgia, cold pain of waist and knee, spasm and numbness of lower limbs and wind-qi pain of the old, and is an adjuvant drug of the formula. The edible white spirit has the efficacy of assisting medicines, is applied to the affected part, and has the effects of relaxing muscles and tendons, promoting blood circulation and relieving pain.
The invention has the positive effects that:
pure Chinese medicine, low cost and wide medicinal material source. The medicine has the effects of dispelling pathogenic wind, relieving pain, promoting blood circulation and relieving swelling. Traumatic synovitis of knee joint is caused by local sprain, external force injury, chronic strain and other meridian injury, unsmooth blood circulation and local retention. The clinical treatment of the disease is very troublesome because the muscles and tendons are not nourished and pathogenic wind, cold, dampness and heat come in the deficiency to aggravate the obstruction of the veins. The product can be used for treating synovitis in acute stage, and has effects in dispelling blood stasis, promoting tissue regeneration, relieving swelling and pain; in the chronic stage, the traditional Chinese medicine composition has the effects of dispelling wind and eliminating dampness, strengthening muscles and bones, avoiding repeated onset of synovitis, recovering normal functions of joints, improving the life quality of patients and solving the problem that no specific external medicine is used for treating knee joint traumatic synovitis at present.
The following further describes the herbs, property and functions of the 7 kinds of Chinese herbs in this formula.
Impatiens balsamina L is sweet, slightly bitter and warm in taste. Dispelling wind and relieving pain, promoting blood circulation and relieving swelling, and can be used for treating rheumatism, lumbago, abdominal pain, amenorrhea, puerperal blood stasis, traumatic injury, superficial infection, furuncle, etc. The soaked white spirit has the effects of promoting blood circulation, removing blood stasis, and quickly relieving swelling and pain.
Dan Shen is bitter and slightly cold. Heart meridian entered, pericardium and liver meridian entered. Promoting blood circulation, removing blood stasis, cooling blood, resolving carbuncle, nourishing blood, tranquilizing mind, and can be used for treating amenorrhea due to blood stagnation, blood stasis, pyocutaneous disease, carbuncle, swelling, and promoting blood circulation by soaking in wine.
Dang Gui is sweet, pungent and warm. It enters liver, heart and spleen meridians. Tonify blood, activate blood, regulate menstruation and alleviate pain. It can be used for treating flaccid paralysis, superficial infection, pyocutaneous disease, traumatic injury, etc., and can be used for treating muscle and joint pain, neuralgia, and regulating immunity.
Frankincense is pungent, bitter and warm. It enters heart, liver and spleen meridians. Promoting blood circulation and activating qi-flowing, relieving pain, detumescence and promoting granulation, is an important medicine for traumatology department, and is used for treating pain symptoms such as traumatic injury, traumatic pain and swelling, rheumatic arthralgia and blood stasis and obstruction. The medicated liquor can enhance therapeutic effect. It is preferably stir-baked.
Mo Yao is bitter and neutral. It enters heart, liver and spleen meridians. Promoting blood circulation, relieving pain, eliminating swelling, and promoting granulation. It is mainly indicated for pain in heart and abdomen, chest pain, traumatic injuries, furuncle, carbuncle, sore and pain due to external obstruction, and should be stir-baked. The frankincense and myrrh wine is externally used for warming channels, activating blood circulation, dispelling wind and relieving pain.
Cyathula root, radix Cyathulae is sweet, slightly bitter and neutral. It enters liver and kidney meridians. Dispel blood stasis, dredge meridians, induce diuresis, treat stranguria, and relieve joint pain. It can be used for treating traumatic injury, rheumatic arthralgia, etc. It is used for knee joint pain by external application after being soaked in wine for promoting blood circulation and removing blood stasis.
Qiannianjian bitter with warm property enters liver and kidney meridians. Has the effects of dispelling wind-damp, strengthening bones and muscles, and relieving swelling and pain. Can be used for treating myasthenia of bones and muscles, arthralgia, spasm and numbness caused by rheumatic arthritis. The wine can warm and dredge blood vessels, strengthen tendons and bones, reduce swelling and alleviate pain, and guide drugs to achieve disease sites.
The functions, indications, cautions and the like of the medicament of the present invention are explained below.
[ function ] dispel wind, alleviate pain, activate blood and reduce swelling.
The external use drug is mainly used for treating traumatic synovitis of knee joints, joint trauma of limbs, sprain, traumatic injury, rheumatoid arthritis, tenosynovitis and the like.
The medicine components include 7 kinds of Chinese medicinal materials including impatiens balsamina, homalomena rhizome, angelica, etc. and edible white spirit in 52-60 degree.
[ Properties ] the product is red clear liquid with special mellow fragrance.
The composition is applied topically to affected parts 2-5 times a day.
[ adverse reactions ] No adverse reactions were observed. If patients with allergic constitution have serious adverse reactions, the patients should go to hospitals to seek medical advice.
Contraindicated for children and pregnant women below 1 year of age.
2. It is contraindicated for skin and mucosa injury.
[ action class ] this product is an over-the-counter drug for surgical and extremity arthralgia.
[ Note ]1, this herb is used in surgery and is contraindicated for taking.
2. Do not come into contact with the eyes.
3. If the affected part has fracture or is red and swollen continuously after administration, the patient should be treated in hospital.
4. Contact dermatitis is prohibited.
5. It is only applied to the affected parts of the joints of the four limbs, so it should be used with cautions for lumbar pain, and not used in other parts.
Storage sealing and light-blocking.
The specific implementation measures, the specific implementation mode of the medicine is clinical application, and are described as follows:
case one Yan A certain person, male, 71 years old, Qianjia town of Shangxi county, allergic constitution, acute allergy. In 2015, the right leg is cold when watering the ground, the right knee joint is slightly painful, the squatting is inconvenient, in 2016, when working in summer, the right leg is soft, the 'clicking' sound is heard, and then the knee joint is sore and painful, so that the user cannot walk. Magnetic resonance imaging examination shows that the meniscus of the right knee joint is slightly damaged, a small amount of effusion is generated in the joint cavity, and the marrow is slightly edematous. The local swelling is relieved through treatment, the walking can be performed, and the symptoms of persistent right knee joint pain are remained. The skin of the joint is obviously hot, and the affected joint can not exert force. The doctor diagnosed gonarthromeningitis caused by meniscal damage. Oral taking of Anbasic acid glucose and Chinese patent medicine synovitis tablet, Qili bone-knitting tablet, external use of bone-setting water or ointment for dredging collaterals and relieving pain, etc., the symptoms are mild, but the symptoms are bad in good time and attack repeatedly. The oral medicine has serious reaction, gastric ulcer, duodenal ulcer and stool bleeding. Adverse reactions such as chest distress and chest pain, ventricular premature beat and the like also occur, and the medicine has to be stopped. The medicine is applied externally for 4 times a day without any delay, pain is stopped on the same day, swelling and pain disappear after continuous use for 15 days, and the medicine is applied to the affected part when farm life is dried in the field and meets rainy days or the farm life is heavy. No relapse occurs for more than two years, and the right knee joint is normal and lives like a normal person.
In case of a certain disease, i.e., a certain Huo, male, 60 years old, Shancai county tower bridge, the body is healthy, the worker is a new life in outing, and 6 years ago, the index finger of the right hand causes tenosynovitis and finger bending due to trauma, and the patient often feels pain at night. The affected fingers are stretched and not straightened all the time. The medicine is externally applied for 3 months in 2020 for 5 times a day, and the affected fingers are normal and free to flex and stretch after being healed in 6 days.
In case of a certain Sanli, a woman is 70 years old in the current year, a person in Shangxi county tower bridge lives in 11 months in 2020, the middle finger of the right hand is accidentally injured, slight red swelling and pain are hard to endure, the medicine is rubbed on the affected part three times a day, a good pain relieving feeling is obtained after the medicine is rubbed for 20 minutes, the swelling is relieved after the medicine is continuously applied for three days, the pain is disappeared, and the pain is recovered to be normal.

Claims (4)

1. A medicine for treating knee joint traumatic synovitis is characterized by comprising 20 g of impatiens balsamina, 10 g of salvia miltiorrhiza, 10 g of angelica, 10 g of prepared frankincense, 10 g of prepared myrrh, 10 g of medicinal cyathula root and 10 g of obscured homalomena rhizome.
2. The medicine according to claim 1, which is prepared by soaking the medicines in proportion in 52-60 degree edible white wine brewed from 500 g of pure grain, sealing for 20-30 days, removing residues, and taking the liquid for external use.
3. The medicine according to claim 1, which is prepared from impatiens balsamina, salvia miltiorrhiza, angelica sinensis, prepared frankincense, prepared myrrh, medicinal cyathula root and obscured homalomena rhizome.
4. The medicament according to claim 1, wherein impatiens balsamina is the main medicament.
CN202011644976.4A 2020-12-23 2020-12-23 Medicine for treating traumatic synovitis of knee joint Pending CN114652783A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011644976.4A CN114652783A (en) 2020-12-23 2020-12-23 Medicine for treating traumatic synovitis of knee joint

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202011644976.4A CN114652783A (en) 2020-12-23 2020-12-23 Medicine for treating traumatic synovitis of knee joint

Publications (1)

Publication Number Publication Date
CN114652783A true CN114652783A (en) 2022-06-24

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ID=82025550

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202011644976.4A Pending CN114652783A (en) 2020-12-23 2020-12-23 Medicine for treating traumatic synovitis of knee joint

Country Status (1)

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