CN112190632A

CN112190632A - Bee venom-containing external-use pharmaceutical composition for dredging collaterals, removing blood stasis, diminishing inflammation and relieving pain

Info

Publication number: CN112190632A
Application number: CN202011183091.9A
Authority: CN
Inventors: 李上星; 张进明; 马荣江; 陈杰; 陈袆宁
Original assignee: Jiangxi Institute Of Apiculture Research Jiangxi Apiculture Technology Promotion Station; Qiandongnan Miao And Dong Autonomous Prefecture Academy Of Agricultural Sciences
Current assignee: Jiangxi Institute Of Apiculture Research Jiangxi Apiculture Technology Promotion Station; Qiandongnan Miao And Dong Autonomous Prefecture Academy Of Agricultural Sciences
Priority date: 2020-10-29
Filing date: 2020-10-29
Publication date: 2021-01-08

Abstract

The invention provides an external application medicament composition containing bee venom for dredging collaterals, removing blood stasis, diminishing inflammation and easing pain, which consists of bee venom, royal jelly, honey, rose oil, litsea cubeba oil, camellia oil, wintergreen oil, turpentine oil, white camphor oil, cassia leaf oil, cinnamic aldehyde oil, soybean oil, safflower oil and clove oil. The bee venom-containing external-use medicament composition for dredging collaterals, removing stasis, diminishing inflammation and easing pain can astringe and compact the skin, so that the skin is more delicate and soft; the massage oil and the scraping oil are used for massaging or scraping related acupuncture points, so that bronchitis and asthma are effectively relieved; has effects in dredging meridians, dispelling blood stasis, relieving inflammation, and relieving pain.

Description

Bee venom-containing external-use pharmaceutical composition for dredging collaterals, removing blood stasis, diminishing inflammation and relieving pain

Technical Field

The invention belongs to the technical field of external application medicaments, and particularly relates to an external application medicament composition containing bee venom for dredging collaterals, removing blood stasis, diminishing inflammation and easing pain.

Background

Meridians and collaterals are important channels for maintaining the circulation of qi and blood of a human body, and if the meridians and collaterals are obstructed, various discomforts can occur. If the patient is careless for a long time, some diseases can be caused, and the health is very bad. The pain of joints, bones, muscles and other parts is usually affected by the obstruction of channels and collaterals and the unsmooth circulation of qi and blood of a human body, so that the normal work and activity of people are greatly disturbed, and even the daily life is affected. In daily life, sprain, cervical vertebra pain, lumbar disc herniation, ankylosing spondylitis, achilles tendonitis, muscle strain, rheumatism, rheumatoid and arthritis become common diseases of modern people, and the probability of the diseases appearing on each person is greatly increased due to changes of life styles. The western medicines for treating the diseases on the market have good curative effects on pain relief, but have general drug effects on recovery of bones and muscles, especially symptoms caused by chronic causes such as cervical spondylosis, lumbar disc herniation and the like, and have poor effects and great side effects.

Disclosure of Invention

The technical problem to be solved by the invention is to provide an external-use medicament composition containing bee venom for dredging collaterals, removing blood stasis, diminishing inflammation and easing pain, aiming at the defects of the prior art, the external-use medicament composition containing bee venom for dredging collaterals, removing blood stasis, diminishing inflammation and easing pain can converge and compact the skin, so that the skin is more delicate and soft; the massage oil and the scraping oil are used for massaging or scraping related acupuncture points, so that bronchitis and asthma are effectively relieved; has effects in dredging meridians, dispelling blood stasis, relieving inflammation, and relieving pain.

In order to solve the technical problems, the invention adopts the technical scheme that: an external liniment medicament composition containing bee venom for dredging collaterals, removing blood stasis, diminishing inflammation and easing pain comprises the following raw materials in parts by weight: 1 to 4 parts of bee venom, 1 to 4 parts of royal jelly, 1 to 4 parts of honey, 2 to 4 parts of rose oil, 1 to 2 parts of litsea cubeba oil, 15 to 25 parts of camellia oil, 5 to 15 parts of wintergreen oil, 2 to 6 parts of turpentine, 2 to 6 parts of white camphor oil, 3 to 7 parts of cassia leaf oil, 15 to 25 parts of cinnamic aldehyde oil, 15 to 25 parts of soybean oil, 3 to 7 parts of safflower oil and 3 to 9 parts of clove oil.

Preferably, the feed consists of the following raw materials in parts by weight: 2 to 3.5 parts of bee venom, 2 to 3.5 parts of royal jelly, 2 to 3.5 parts of honey, 2.5 to 3.5 parts of rose oil, 1.2 to 1.8 parts of litsea cubeba oil, 18 to 23 parts of oil-tea camellia oil, 8 to 12 parts of wintergreen oil, 3 to 5 parts of turpentine oil, 3 to 5 parts of white camphor oil, 4 to 6 parts of cassia leaf oil, 17 to 22 parts of cinnamic aldehyde oil, 15 to 25 parts of soybean oil, 4 to 6 parts of safflower oil and 5 to 8 parts of clove oil.

Preferably, the feed consists of the following raw materials in parts by weight: 3 parts of bee venom, 3 parts of royal jelly, 3 parts of honey, 3 parts of rose oil, 1.5 parts of litsea cubeba oil, 20 parts of camellia oil, 10 parts of wintergreen oil, 4 parts of turpentine, 4 parts of white camphor oil, 5 parts of bay leaf oil, 20 parts of cinnamic aldehyde oil, 20 parts of soybean oil, 5 parts of safflower oil and 6 parts of clove oil.

The invention also provides a method for preparing the bee venom-containing externally-applied medicament composition for dredging collaterals, removing stasis, diminishing inflammation and easing pain, which comprises the following steps:

s1, mixing the rose oil, the litsea cubeba oil and the oil tea oil at the temperature of 30-55 ℃ to obtain a mixed solution a;

s2, sequentially adding bee venom, royal jelly and honey into the mixed solution a obtained in the step S1 at the temperature of 30-55 ℃, stirring and mixing, and sieving by a 80-mesh sieve to obtain mixed solution b;

s3, adding wintergreen oil, turpentine oil, white camphor oil, bay leaf oil, cinnamic aldehyde oil, soybean oil, safflower oil and clove oil into the mixed solution b obtained in S2, uniformly mixing, sieving with a 60-mesh sieve, and performing pasteurization to obtain the bee venom-containing external liniment composition for dredging collaterals, removing blood stasis, diminishing inflammation and relieving pain.

Compared with the prior art, the invention has the following advantages:

1. the litsea cubeba oil and the turpentine oil are used as the dispersant and the stabilizer, so that bee venom can effectively and quickly permeate into skin and enter soft tissues, the effects of treating or eradicating rheumatoid arthritis, rheumatic arthritis, scapulohumeral periarthritis, lumbar disc herniation and hyperosteogeny can be achieved, royal jelly and honey can quickly permeate into the skin, inflammation and pain are reduced, the litsea cubeba oil is favorable for expanding blood vessels, the litsea cubeba oil has an antibacterial effect, has a good inhibiting effect on various bacteria and mould, and is favorable for diminishing inflammation and removing blood stasis. The wintergreen oil and the safflower oil have obvious effects of relieving fever, easing pain, resisting inflammation, reducing swelling, dredging collaterals and removing blood stasis, and have good effects on traumatic injury, strain, gout and the like; the rose oil can relieve anxiety, depression and pain after entering human body through olfactory nerve. The oil tea oil has the functions of clearing heat, eliminating dampness, killing parasites and detoxifying; the white camphor oil has the effects of expelling wind and clearing away cold, regulating qi and activating blood circulation, relieving pain and itching, dredging orifices and avoiding dirt, warming middle-jiao and relieving pain, and promoting diuresis and killing parasites; the cassia leaf oil and the cinnamic aldehyde oil have the effects of warming channels, dispelling cold, promoting qi circulation, promoting blood circulation and relieving pain; the clove oil has the effects of treating rheumatalgia and neuralgia; the soybean oil is mainly used for regulating the concentration of the external liniment composition containing bee venom.

2. The bee venom-containing external liniment composition for dredging collaterals, removing blood stasis, diminishing inflammation and easing pain can astringe and compact the skin, so that the skin is more delicate and soft; the massage oil and the scraping oil are used for massaging or scraping related acupuncture points, so that bronchitis and asthma are effectively relieved; has effects in dredging collaterals, removing blood stasis, relieving inflammation and pain, and can be used for treating scapulohumeral periarthritis, vasculitis, rheumatoid disease, rheumatic arthritis, prolapse of lumbar intervertebral disc, hyperosteogeny, strain, traumatic injury, gout, sinusitis, common cold, headache, burn, and scald.

3. The bee venom-containing external application medicament composition for dredging collaterals, removing stasis, diminishing inflammation and easing pain has natural and green raw material sources, has no toxic or side effect, good stability, can quickly permeate into subcutaneous tissues, can relieve the pain of patients in about 10 minutes, and can eradicate chronic diseases such as rheumatoid arthritis, scapulohumeral periarthritis, lumbar disc herniation, gout, hyperosteogeny and the like after long-term use.

The present invention will be described in further detail with reference to examples.

Detailed Description

Example 1

The bee venom-containing externally-applied medicament composition for dredging collaterals, removing stasis, diminishing inflammation and easing pain in the embodiment is composed of the following raw materials in parts by weight: 3 parts of bee venom, 3 parts of royal jelly, 3 parts of honey, 3 parts of rose oil, 1.5 parts of litsea cubeba oil, 20 parts of camellia oil, 10 parts of wintergreen oil, 4 parts of turpentine, 4 parts of white camphor oil, 5 parts of bay leaf oil, 20 parts of cinnamic aldehyde oil, 20 parts of soybean oil, 5 parts of safflower oil and 6 parts of clove oil.

The embodiment also provides a method for preparing the bee venom-containing externally-applied medicament composition for dredging collaterals, removing stasis, diminishing inflammation and easing pain, which comprises the following steps:

s1, mixing the rose oil, the litsea cubeba oil and the oil tea oil at the temperature of 55 ℃ to obtain a mixed solution a;

s2, sequentially adding bee venom, royal jelly and honey into the mixed solution a obtained in the step S1 at the temperature of 55 ℃, stirring and mixing, and sieving by a 80-mesh sieve to obtain mixed solution b;

Basic information of a patient is primarily diagnosed in 7 months and 17 days in 2019 by Wangzhe and girl.

The main complaints are: numbness of both lower extremities and left upper extremity for one year.

The current medical history: the numbness of the two lower limbs and the left upper limb is caused one year ago, and the examination of local county people hospital shows that the cervical vertebra and lumbar vertebra sequence has no bulging or out-of-shape change, the acupuncture, massage and warm acupuncture are better and have intermittent attack, and the numbness of the two lower limbs and the left upper limb is caused by fatigue before half a month. Diagnosis: numbness of both lower limbs and left upper limb, pain caused by wind-cold, needle-point pain at night, and fatigue aggravation, and hot compress is required to relieve pain.

10g of the bee venom-containing external liniment composition for dredging collaterals, removing blood stasis, diminishing inflammation and relieving pain prepared in the embodiment is uniformly smeared on a pain part every time, three times a day, 15 days are a treatment course, and the doctor can be retested after one month.

In 2019, 8 and 18, after the bee venom-containing externally-applied medicament composition for treating meridian obstruction removing, stasis removing, inflammation diminishing and pain easing of the embodiment is smeared for seven days, the numbness of the upper limbs and the upper limbs on the left side are improved, the needle-point pain at night is improved, and the bee venom-containing externally-applied medicament composition on the upper part is continuously used for one month.

In 2019, 18 in 9 months, the external liniment composition containing bee venom is applied to the upper part of the affected part, so that various symptoms are reduced, fatigue is aggravated and relieved, needle-point pain at night is almost absent, numbness of the upper limbs on the two lower limbs and the left upper limb is almost absent, and the external liniment composition containing bee venom is taken for standby application.

In 2019, 10 and 20 days, the telephone is followed up, all symptoms are relieved, and no pain is caused when the patient is tired.

Example 2

The bee venom-containing externally-applied medicament composition for dredging collaterals, removing stasis, diminishing inflammation and easing pain in the embodiment is composed of the following raw materials in parts by weight: 1 part of bee venom, 4 parts of royal jelly, 4 parts of honey, 2 parts of rose oil, 2 parts of litsea cubeba oil, 15 parts of camellia oil, 15 parts of wintergreen oil, 2 parts of turpentine, 2 parts of white camphor oil, 3 parts of bay leaf oil, 25 parts of cinnamaldehyde oil, 15 parts of soybean oil, 3 parts of safflower oil and 3 parts of clove oil.

s1, mixing the rose oil, the litsea cubeba oil and the oil tea oil at the temperature of 30 ℃ to obtain a mixed solution a;

s2, sequentially adding bee venom, royal jelly and honey into the mixed solution a obtained in the step S1 at the temperature of 30 ℃, stirring and mixing, and sieving by a 80-mesh sieve to obtain mixed solution b;

The basic information of the patient is completely aged, male age 65, and the patient is primarily diagnosed in 2018, 3 and 6 days.

The main complaints are: swelling and purple sensation in the right lower limb and abdominal distension.

The current medical history: and 4 days later, the ground dug by the house is dropped into a pit with the depth of 2 meters, and the image examination shows that the ankle bone fracture of the right leg is detected by local county hospitals from the next day. The patient is discharged at home for treatment after being hospitalized for one day for economic reasons.

10g of the external liniment composition containing bee venom for dredging collaterals, removing blood stasis, diminishing inflammation and easing pain prepared in the embodiment is uniformly smeared on the abdominal distension and pain part, and the pain is relieved at the abdominal distension and pain part within about 10 minutes; 20g of the swollen and purple part of the right lower limb is taken three times a day, 10 days are taken as a treatment course, and the patient can go on the ground after a month for a return visit. The telephone follow-up in 3 and 26 months in 2018 has all good symptoms and no pain during working.

Example 3

The bee venom-containing externally-applied medicament composition for dredging collaterals, removing stasis, diminishing inflammation and easing pain in the embodiment is composed of the following raw materials in parts by weight: 4 parts of bee venom, 1 part of royal jelly, 1 part of honey, 4 parts of rose oil, 1 part of litsea cubeba oil, 25 parts of camellia oil, 5 parts of wintergreen oil, 6 parts of turpentine, 6 parts of white camphor oil, 7 parts of bay leaf oil, 15 parts of cinnamaldehyde oil, 25 parts of soybean oil, 7 parts of safflower oil and 9 parts of clove oil.

The preparation method of the external-use pharmaceutical composition containing bee venom for dredging collaterals, removing blood stasis, diminishing inflammation and relieving pain in the embodiment is the same as the method in the embodiment 1.

The basic information of the patient is the first diagnosis of a woman in the age of 59, 10 months and 15 days in 2015.

The main complaints are: scapulohumeral periarthritis, shoulder pain for more than three months, often pain and awakening in half night, and sleeping can only be in one posture, and severe pain of shoulder can be caused by changing the posture. Soreness and pain in the shoulder, weakness in movement, aggravated fatigue, exhaustion with a little dry and loose sensation, soreness and weakness of the waist and knees, dizziness, pale complexion, etc.

The effect of the treatment is poor after the disease is treated by massage. When the patient goes to a hospital for examination, the pain or tenderness at the outer side of the shoulder joint can be seen, the pain at the rear side often reaches the scapular part and the outer rear edge of the upper limb, the upper limb is straightened, abducted, adducted and stretched out, the functional disorder is caused, the hand can not touch the shoulder at the same side when bending the elbow, the elbow bending action can not be completed when the arm is stretched backwards, and the front edge and the rear edge of the deltoid muscle can have obvious tenderness. Doctor of traditional Chinese medicine thinks that she belongs to body weakness and overwork, which causes kidney essence and blood deficiency to cause kidney yin and yang deficiency.

After the external liniment composition containing the bee venom for dredging collaterals, removing blood stasis, diminishing inflammation and easing pain is used for hot compress at the pain part of scapulohumeral periarthritis, the pain part is uniformly smeared, a scraping plate is used for scraping until the external liniment composition containing the bee venom permeates into skin, the external liniment composition is used twice a day, 15 days are a treatment course, and the dosage is not limited according to the size of the scraping area. The re-diagnosis is already recovered after one month.

In 2020, 10 and 15 days, all symptoms are not relapsed after telephone follow-up.

Example 4

The bee venom-containing externally-applied medicament composition for dredging collaterals, removing stasis, diminishing inflammation and easing pain in the embodiment is composed of the following raw materials in parts by weight: 3.5 parts of bee venom, 3.5 parts of royal jelly, 3.5 parts of honey, 2.5 parts of rose oil, 1.2 parts of litsea cubeba oil, 18 parts of camellia oil, 8 parts of wintergreen oil, 3 parts of turpentine, 5 parts of white camphor oil, 6 parts of bay leaf oil, 17 parts of cinnamic aldehyde oil, 15 parts of soybean oil, 4 parts of safflower oil and 5 parts of clove oil.

Basic information of a patient is about Luo Shi, female, 50 years old, and 18 initial diagnoses in 2017 and 5 months.

The main complaints are: low back pain, numbness and pain in the right leg, limping, difficulty in walking.

The current medical history: in 2017, 5, 1 and more than 10 hours of continuous driving of Luo-Zhi, the lower waist begins to be painful in the middle. The lumbago occasionally occurs two years ago, so that the rest massage can be relieved. After purchasing the analgesic plaster this time. The next day, the vehicle is driven to return on the original way. Pain in the way spreads to the legs, discomfort of standing and sitting.

The confirmed diagnosis of 5-month and 8-day hospital shooting is as follows: L5/S1 was associated with narrowing of the right crypt, compression of the dural sac and corresponding nerve roots, and bony hyperplasia of the vertebral bodies. After one week, walking was difficult.

After the hyperosteogeny pain part is hot-compressed, the hyperosteogeny pain part is uniformly smeared, a scraping plate is used for scraping until the external liniment composition containing bee venom permeates into the skin, the external liniment composition is used twice a day, 15 days are a treatment course, and the rehabilitation is realized after the doctor rechecking is carried out after one month according to the size of the scraping area without limit dosage.

The disease does not recur after telephone follow-up in 5-15 days in 2020.

Example 5

The bee venom-containing externally-applied medicament composition for dredging collaterals, removing stasis, diminishing inflammation and easing pain in the embodiment is composed of the following raw materials in parts by weight: 2 parts of bee venom, 2 parts of royal jelly, 2 parts of honey, 3.5 parts of rose oil, 1.8 parts of litsea cubeba oil, 23 parts of camellia oil, 12 parts of wintergreen oil, 5 parts of turpentine, 3 parts of white camphor oil, 4 parts of bay leaf oil, 22 parts of cinnamic aldehyde oil, 25 parts of soybean oil, 6 parts of safflower oil and 8 parts of clove oil.

Patient basic information is old, age: age 53. 9/month 5 preliminary diagnosis in 2018.

The main complaints are: headache, dizziness, neck rigidity, discomfort, failure of lifting the skull, heavy shoulder pain, failure of lifting, elbow pain, failure of straightening, swelling pain of the wrists, swelling pain of the fingers, morning stiffness, failure of holding and pinching things, lumbosacral pain, obvious tenderness, failure of sitting for a long time, discomfort of the crotch, swelling pain of the knees, swelling pain of the ankles, shins and feet, body sleepiness, weakness, failure of standing, extreme pain, hyperhidrosis, thirst, but not desire to drink, pale tongue, white and thin fur, deep pulse, fear of wind-cold, wandering pain points, aggravation, negative resistance to 'O', positive rheumatoid factor, positive C protein reaction, blood sedimentation of 120mmo/h, lumbar X-ray sign, lumbar hyperplasia, marginal hyperosteogeny, no obvious stenosis in intervertebral space, unclosed L5-S1 vertebral foramen, sacralization and recessive lumbar fissure.

The current medical history: after the patient is treated by a large amount of transfusion, the patient has heavy and swollen whole body, and can not walk independently on lower limb joints, and then a large amount of Xuanqi Tongbi capsules, glucide and other medicines are taken, so the condition of the patient is more serious. The diagnosis is as follows: rheumatic arthritis (middle stage).

After the external liniment composition containing the bee venom for dredging collaterals, removing blood stasis, diminishing inflammation and easing pain is used for hot compress at a pain part of rheumatoid arthritis, the pain part is uniformly smeared, a scraping plate is used for scraping until the external liniment composition containing the bee venom permeates into skin, the external liniment composition is used twice a day, 15 days are a treatment course, and the dosage is not limited according to the size of the scraping area. Rehabilitation is carried out after three treatment courses. The disease does not recur after the return diagnosis of one year.

The above description is only for the preferred embodiment of the present invention, and is not intended to limit the present invention in any way. Any simple modification, change and equivalent changes of the above embodiments according to the technical essence of the invention are still within the protection scope of the technical solution of the invention.

Claims

1. An external liniment medicament composition containing bee venom for dredging collaterals, removing blood stasis, diminishing inflammation and easing pain is characterized by comprising the following raw materials in parts by weight: 1 to 4 parts of bee venom, 1 to 4 parts of royal jelly, 1 to 4 parts of honey, 2 to 4 parts of rose oil, 1 to 2 parts of litsea cubeba oil, 15 to 25 parts of camellia oil, 5 to 15 parts of wintergreen oil, 2 to 6 parts of turpentine, 2 to 6 parts of white camphor oil, 3 to 7 parts of cassia leaf oil, 15 to 25 parts of cinnamic aldehyde oil, 15 to 25 parts of soybean oil, 3 to 7 parts of safflower oil and 3 to 9 parts of clove oil.

2. The externally-applied medicament composition containing bee venom for dredging collaterals, removing stasis, diminishing inflammation and easing pain as claimed in claim 1 is characterized by comprising the following raw materials in parts by weight: 2 to 3.5 parts of bee venom, 2 to 3.5 parts of royal jelly, 2 to 3.5 parts of honey, 2.5 to 3.5 parts of rose oil, 1.2 to 1.8 parts of litsea cubeba oil, 18 to 23 parts of oil-tea camellia oil, 8 to 12 parts of wintergreen oil, 3 to 5 parts of turpentine oil, 3 to 5 parts of white camphor oil, 4 to 6 parts of cassia leaf oil, 17 to 22 parts of cinnamic aldehyde oil, 15 to 25 parts of soybean oil, 4 to 6 parts of safflower oil and 5 to 8 parts of clove oil.

3. The externally-applied medicament composition containing bee venom for dredging collaterals, removing stasis, diminishing inflammation and easing pain as claimed in claim 2 is characterized by comprising the following raw materials in parts by weight: 3 parts of bee venom, 3 parts of royal jelly, 3 parts of honey, 3 parts of rose oil, 1.5 parts of litsea cubeba oil, 20 parts of camellia oil, 10 parts of wintergreen oil, 4 parts of turpentine, 4 parts of white camphor oil, 5 parts of bay leaf oil, 20 parts of cinnamic aldehyde oil, 20 parts of soybean oil, 5 parts of safflower oil and 6 parts of clove oil.