CN115487230A - A topical Chinese medicinal composition for promoting blood circulation, dredging collaterals, warming channels and relieving pain, and its preparation method - Google Patents
A topical Chinese medicinal composition for promoting blood circulation, dredging collaterals, warming channels and relieving pain, and its preparation method Download PDFInfo
- Publication number
- CN115487230A CN115487230A CN202211266279.9A CN202211266279A CN115487230A CN 115487230 A CN115487230 A CN 115487230A CN 202211266279 A CN202211266279 A CN 202211266279A CN 115487230 A CN115487230 A CN 115487230A
- Authority
- CN
- China
- Prior art keywords
- parts
- root
- pain
- chinese medicine
- traditional chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/56—Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses an external traditional Chinese medicine composition for promoting blood circulation, removing obstruction in channels, warming channels and relieving pain and a preparation method thereof, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1000 to 2000 parts of common monkshood mother root, 1000 to 2000 parts of kusnezoff monkshood root, 1000 to 1200 parts of nux vomica, 800 to 1000 parts of clematis root, 700 to 900 parts of doubleteeth pubescent angilica root, 700 to 900 parts of incised notopterygium rhizome, 600 to 900 parts of Chinese angelica, 600 to 900 parts of safflower, 600 to 900 parts of Szechuan lovage rhizome and 500 to 900 parts of corydalis tuber; the invention combines practice and application according to the theory of traditional Chinese medicine, selects the traditional Chinese medicine raw materials with the functions of warming channels, relieving pain, dissipating binds, relieving swelling, dispelling wind, removing dampness, promoting blood circulation and promoting qi circulation, has the effects of promoting blood circulation, dredging collaterals, warming channels, relieving pain, removing blood stasis and relieving swelling by compatibility of medicines, is suitable for arthritis, cervical spondylosis, lumbar intervertebral disc protrusion, lumbar muscle strain, hyperosteogeny, sciatica and other symptoms, has obvious effect and quick response, and does not have toxic or side effect on a human body.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine compositions, in particular to an external traditional Chinese medicine composition for promoting blood circulation, removing obstruction in channels, warming channels and relieving pain and a preparation method thereof.
Background
Joint injury belongs to the category of tendon injury in traditional Chinese medicine. The traditional medicine considers that swelling and pain caused by tendon injury are caused by qi and blood channels and unsmooth circulation of qi and blood after a human body is injured by external force, namely the pathological mechanism of tendon injury is qi stagnation and blood coagulation, and the treatment principle is activating blood circulation to dissipate blood stasis, and reducing swelling and relieving pain. Meanwhile, some chronic diseases also affect the daily life quality of people, such as arthritis, cervical spondylosis, lumbar intervertebral disc protrusion, lumbar muscle strain, hyperosteogeny, sciatica and the like.
At present, the aim of relieving symptoms is achieved by western medicine treatment for most of the diseases, the diseases are relieved or disappeared after the medicine is taken, but some symptoms can be repeated after the medicine is stopped, so that the problem of low cure rate exists when the western medicine is used for treating the diseases, and the western medicine is frequently taken to cause damage to intestines, stomachs, livers, kidneys and the like of a human body.
Disclosure of Invention
The invention aims to provide an external traditional Chinese medicine composition for promoting blood circulation, removing obstruction in channels, warming channels and relieving pain and a preparation method thereof.
In order to achieve the above purpose of the present invention, the following technical solutions are adopted:
the invention provides an external traditional Chinese medicine composition for promoting blood circulation, removing obstruction in channels, warming channels and relieving pain, which is prepared from the following raw materials in parts by weight:
1000-2000 parts of radix aconiti, 1000-2000 parts of radix aconiti kusnezoffii, 1000-1200 parts of nux vomica, 800-1000 parts of radix clematidis, 700-900 parts of radix angelicae pubescentis, 700-900 parts of notopterygium root, 600-900 parts of angelica, 600-900 parts of safflower, 600-900 parts of ligusticum wallichii and 500-900 parts of rhizoma corydalis.
The raw materials adopted in the invention are as follows:
monkshood: pungent, bitter and hot; it is toxic. It enters heart, liver, kidney and spleen meridians. Dispel wind and dampness, warm meridians and alleviate pain. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, cold hernia pain, anesthesia and pain relieving.
Kusnezoff monkshood root: pungent, bitter, hot; it is toxic. It enters heart, liver, kidney and spleen meridians. Dispel wind and remove dampness, warm meridians and alleviate pain. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, cold hernia pain, and anesthesia and pain relieving.
Semen strychni: bitter and warm; it is toxic. It enters liver and spleen meridians. Unblock collaterals to alleviate pain, dissipate nodulation and resolve swelling. Can be used for treating traumatic injury, fracture, rheumatism, paralysis, carbuncle, sore, and sore throat.
Clematis root: pungent, salty and warm. It enters bladder meridian. Dispel wind-damp, unblock collaterals. Can be used for treating rheumatalgia, numbness of limbs, spasm of tendons and vessels, and difficulty in flexion and extension.
Radix angelicae pubescentis: pungent, bitter and slightly warm. It enters kidney and bladder meridians. Dispel wind and dampness, relieve arthralgia and alleviate pain. Can be used for treating arthralgia due to wind-cold-dampness, lumbago, gonalgia, headache due to wind-cold-yin deficiency, and headache due to wind-cold-dampness.
Notopterygium root: pungent, bitter and warm. It enters bladder and kidney meridians. Relieve exterior syndrome, dispel cold, expel wind and remove dampness, and alleviate pain. Can be used for treating wind-cold type common cold, headache, stiff neck, rheumatalgia, and soreness of shoulder and back.
Chinese angelica: sweet, pungent and warm. It enters liver, heart and spleen meridians. Tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness, and constipation. The wine angelica sinensis can activate blood and promote menstruation. Can be used for treating amenorrhea, dysmenorrhea, rheumatalgia, and traumatic injury.
Safflower: pungent and warm. It enters heart and liver meridians. Promoting blood circulation, dredging channels, removing blood stasis and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, pricking pain in chest and hypochondrium, traumatic injury, and swelling and pain due to pyocutaneous disease.
Ligusticum wallichii: pungent and warm. It enters liver, gallbladder and pericardium meridians. Promote blood circulation and move qi, dispel wind and alleviate pain. Can be used for treating thoracic obstruction, cardialgia, stabbing pain in chest and hypochondrium, traumatic injury, menoxenia, amenorrhea, dysmenorrhea, abdominal mass, headache, and rheumatalgia.
Corydalis tuber: pungent, bitter and warm. It enters liver and spleen meridians. Activate blood, move qi, alleviate pain. Can be used for treating chest and hypochondrium, abdominal pain, thoracic obstruction, cardialgia, amenorrhea, dysmenorrhea, puerperal blood stasis, and traumatic injury with swelling and pain.
The invention combines practice and application according to the theory of traditional Chinese medicine, selects the traditional Chinese medicine raw materials with the functions of warming channels, relieving pain, dissipating binds, relieving swelling, dispelling wind, removing dampness, promoting blood circulation and promoting qi circulation, has the effects of promoting blood circulation, dredging collaterals, warming channels, relieving pain, removing blood stasis and relieving swelling by compatibility of medicines, is suitable for arthritis, cervical spondylosis, lumbar intervertebral disc protrusion, lumbar muscle strain, hyperosteogeny, sciatica and other symptoms, has obvious effect and quick response, and does not have toxic or side effect on a human body.
Preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight:
1800 parts of common monkshood mother root, 1500 parts of kusnezoff monkshood root, 1500 parts of nux vomica, 1000 parts of clematis root, 800 parts of doubleteeth pubescent angilica root, 760 parts of incised notopterygium rhizome, 690 parts of Chinese angelica, 650 parts of safflower, 630 parts of szechuan lovage rhizome and 600 parts of corydalis tuber.
Preferably, the raw materials further comprise borneol and laurocapram.
The second aspect of the present invention provides a preparation method of the above traditional Chinese medicine composition, the preparation method comprising the following steps:
(a) Coarsely crushing and mixing radix Aconiti, radix Aconiti Kusnezoffii, semen Strychni, radix Clematidis, radix Angelicae Pubescentis, notopterygii rhizoma, radix Angelicae sinensis, carthami flos, rhizoma Ligustici Chuanxiong and rhizoma corydalis to obtain a mixture;
(b) Soaking the mixture in ethanol, filtering, and collecting filtrate and residue;
(c) Leaching the filter residue by using ethanol to obtain a leachate;
(d) Mixing the filtrate and the percolate, adding Borneolum Syntheticum and laurocapram, and mixing to obtain the Chinese medicinal composition.
Preferably, in the step (a), the mesh size of the mixed material is not less than 20 meshes.
Preferably, in the step (b), the mass ratio of the mixed material to the ethanol is 1: 2-4.
Preferably, in the step (b), the soaking temperature is normal temperature, and the soaking time is 5-7 d.
Preferably, in the step (c), the mass of the ethanol adopted is 2 to 4 times of that of the mixed material.
Preferably, in the step (d), the adding content of the borneol is 0.3-0.6%.
Preferably, in the step (d), the addition content of laurocapram is 0.1-0.2%.
Compared with the prior art, the invention has the beneficial effects that at least:
the invention combines the practical application according to the theory of traditional Chinese medicine, selects the traditional Chinese medicine raw materials with the functions of warming channels, relieving pain, eliminating stagnation, reducing swelling, dispelling wind, removing dampness, promoting blood circulation and promoting qi circulation, has the effects of promoting blood circulation, dredging collaterals, warming channels, relieving pain, removing blood stasis and reducing swelling by compatibility of medicines, is suitable for the diseases such as arthritis, cervical spondylosis, lumbar intervertebral disc protrusion, lumbar muscle strain, hyperosteogeny, sciatica and the like, has obvious effect and quick response and has no toxic or side effect on human body.
Detailed Description
The following describes embodiments of the present invention in detail with reference to the following embodiments. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only used as examples, and the protection scope of the present invention is not limited thereby.
It is to be noted that, unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the invention pertains.
Example 1
The embodiment is a traditional Chinese medicine composition for external use, promoting blood circulation, removing obstruction in channels, warming channels and relieving pain, which is prepared from the following raw materials in parts by weight:
1000 parts of common monkshood mother root, 1000 parts of kusnezoff monkshood root, 1200 parts of nux vomica, 1000 parts of clematis root, 700 parts of doubleteeth pubescent angilica root, 700 parts of incised notopterygium rhizome, 600 parts of Chinese angelica, 900 parts of safflower, 600 parts of szechuan lovage rhizome and 900 parts of corydalis tuber.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(a) Coarsely crushing and mixing radix Aconiti, radix Aconiti Kusnezoffii, semen Strychni, radix Clematidis, radix Angelicae Pubescentis, notopterygii rhizoma, radix Angelicae sinensis, carthami flos, rhizoma Ligustici Chuanxiong and rhizoma corydalis to obtain a mixture with a mesh size of not less than 20 meshes;
(b) Soaking the mixture in ethanol at normal temperature for 7d according to the mass ratio of the mixture to ethanol of 1: 2, filtering, and collecting filtrate and residue;
(c) The filter residue is leaked by adopting ethanol to obtain a leakage solution, wherein the mass of the adopted ethanol is 4 times of that of the mixed material;
(d) Mixing the filtrate and the percolate, adding Borneolum Syntheticum and laurocapram, and mixing to obtain the Chinese medicinal composition, wherein the addition content of Borneolum Syntheticum is 0.3%, and the addition content of laurocapram is 0.2%.
Example 2
The embodiment is a traditional Chinese medicine composition for external use, promoting blood circulation, removing obstruction in channels, warming meridians and relieving pain, which is prepared from the following raw materials in parts by weight:
2000 parts of common monkshood mother root, 2000 parts of kusnezoff monkshood root, 1000 parts of nux vomica, 800 parts of clematis root, 900 parts of doubleteeth pubescent angilica root, 900 parts of incised notopterygium rhizome, 900 parts of Chinese angelica, 600 parts of safflower, 900 parts of szechuan lovage rhizome and 500 parts of corydalis tuber.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(a) Coarsely crushing and mixing radix Aconiti, radix Aconiti Kusnezoffii, semen Strychni, radix Clematidis, radix Angelicae Pubescentis, notopterygii rhizoma, radix Angelicae sinensis, carthami flos, rhizoma Ligustici Chuanxiong and rhizoma corydalis to obtain a mixed material with a mesh size of not less than 20 meshes;
(b) Soaking the mixed material in ethanol at normal temperature for 5d according to the mass ratio of the mixed material to ethanol of 1: 4, filtering, and collecting filtrate and residue;
(c) The filter residue is leaked by adopting ethanol to obtain a leakage solution, wherein the mass of the adopted ethanol is 2 times of that of the mixed material;
(d) Mixing the filtrate and the percolate, adding Borneolum Syntheticum and laurocapram, and mixing to obtain the Chinese medicinal composition, wherein the addition content of Borneolum Syntheticum is 0.6%, and the addition content of laurocapram is 0.1%.
Example 3
The embodiment is a traditional Chinese medicine composition for external use, promoting blood circulation, removing obstruction in channels, warming channels and relieving pain, which is prepared from the following raw materials in parts by weight:
1800 parts of common monkshood mother root, 1500 parts of kusnezoff monkshood root, 1500 parts of nux vomica, 1000 parts of clematis root, 800 parts of doubleteeth pubescent angilica root, 760 parts of incised notopterygium rhizome, 690 parts of Chinese angelica, 650 parts of safflower, 630 parts of szechuan lovage rhizome and 600 parts of corydalis tuber.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(a) Coarsely crushing and mixing radix Aconiti, radix Aconiti Kusnezoffii, semen Strychni, radix Clematidis, radix Angelicae Pubescentis, notopterygii rhizoma, radix Angelicae sinensis, carthami flos, rhizoma Ligustici Chuanxiong and rhizoma corydalis to obtain a mixed material with a mesh size of not less than 20 meshes;
(b) Soaking the mixed material in ethanol at normal temperature for 6d according to the mass ratio of the mixed material to the ethanol of 1: 3, filtering, and collecting filtrate and filter residue;
(c) Adopting ethanol to leak the filter residue to obtain a leakage solution, wherein the mass of the adopted ethanol is 3 times of that of the mixed material;
(d) Mixing the filtrate and the percolate, adding Borneolum Syntheticum and laurocapram, and mixing to obtain the Chinese medicinal composition, wherein the addition content of Borneolum Syntheticum is 0.5%, and the addition content of laurocapram is 0.1%.
Example 4
The embodiment is a traditional Chinese medicine composition for external use, promoting blood circulation, removing obstruction in channels, warming channels and relieving pain, which is prepared from the following raw materials in parts by weight:
1800 parts of common monkshood mother root, 1500 parts of kusnezoff monkshood root, 1500 parts of nux vomica, 1000 parts of clematis root, 800 parts of doubleteeth pubescent angilica root, 760 parts of incised notopterygium rhizome, 690 parts of Chinese angelica, 650 parts of safflower, 630 parts of szechuan lovage rhizome and 600 parts of corydalis tuber.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(a) Coarsely crushing and mixing radix Aconiti, radix Aconiti Kusnezoffii, semen Strychni, radix Clematidis, radix Angelicae Pubescentis, notopterygii rhizoma, radix Angelicae sinensis, carthami flos, rhizoma Ligustici Chuanxiong and rhizoma corydalis to obtain a mixed material with a mesh size of not less than 20 meshes;
(b) Soaking the mixture in ethanol at normal temperature for 6 days according to the mass ratio of the mixture to ethanol of 1: 3, filtering, and collecting filtrate and residue;
(c) Adopting ethanol to leak the filter residue to obtain a leakage solution, wherein the mass of the adopted ethanol is 3 times of that of the mixed material;
(d) Mixing the filtrate and the percolate, adding Borneolum Syntheticum, and mixing to obtain the Chinese medicinal composition, wherein the adding content of Borneolum Syntheticum is 0.5%.
Comparative example 1
The comparative example is an external traditional Chinese medicine composition for promoting blood circulation, removing obstruction in channels, warming channels and relieving pain, and the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight:
1800 parts of common monkshood mother root, 1500 parts of kusnezoff monkshood root, 1500 parts of nux vomica, 1000 parts of clematis root, 800 parts of doubleteeth pubescent angilica root, 760 parts of incised notopterygium rhizome, 690 parts of Chinese angelica, 650 parts of safflower, 630 parts of szechuan lovage rhizome and 600 parts of corydalis tuber.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(a) Coarsely crushing and mixing radix Aconiti, radix Aconiti Kusnezoffii, semen Strychni, radix Clematidis, radix Angelicae Pubescentis, notopterygii rhizoma, radix Angelicae sinensis, carthami flos, rhizoma Ligustici Chuanxiong and rhizoma corydalis to obtain a mixed material with a mesh size of not less than 20 meshes;
(b) Soaking the mixed material in ethanol at normal temperature for 6d according to the mass ratio of the mixed material to 60% ethanol solution of 1: 3, filtering, and collecting filtrate and residue;
(c) Adopting 60% ethanol solution to leak the filter residue to obtain a leakage solution, wherein the mass of the adopted ethanol solution is 3 times of that of the mixed material;
(d) Mixing the filtrate and the percolate, adding Borneolum Syntheticum and laurocapram, and mixing to obtain the Chinese medicinal composition, wherein the addition content of Borneolum Syntheticum is 0.5%, and the addition content of laurocapram is 0.1%.
Examples of the experiments
The patients with waist and leg pain, rheumatic pain and arthralgia are selected for the accumulated characterization, wherein the patients with waist and leg pain are 146 patients, 56 patients with waist and leg pain, 48 patients with rheumatic pain and 42 patients with arthralgia; randomly dividing each pain patient into 6 groups, wherein 8 patients have rheumatism pain, 7 patients have joint pain, 10 patients have waist and leg pain in groups 1-2, and the other groups have 9 patients;
respectively obtaining the traditional Chinese medicine compositions in examples 1-4 and comparative example 1, and purchasing a commercially available collaterals activating and pain relieving pill for treating pain, wherein the group 1 adopts a commercially available medicine for treatment; 2, the 2 nd to 6 th groups are respectively treated by the traditional Chinese medicine compositions in the embodiments 1 to 4 and the comparative example 1 in sequence;
the treatment method of the commercially available drugs is carried out according to the drug instruction; the traditional Chinese medicine compositions in the examples 1 to 4 and the comparative example 1 are applied by adopting an aqueous plaster patch, 5ml of the traditional Chinese medicine composition is added into each application, and the application is carried out three times a day; each application is not less than 2h, and after 7 days of accumulated treatment, the treatment effect is evaluated:
the evaluation criteria are as follows: the pain levels before and after treatment were determined for the patients as follows:
0 degrees showed no pain; the degree I is mild pain, no pain is caused in a rest state, and pain can be felt in activity; the II degree shows moderate pain, pain can be felt in a resting state, the pain is aggravated during movement, and normal rest is influenced; the III degree is marked by severe pain, the pain is obvious in a lying state, and the pain can not be relieved without medicines; the IV degree is expressed as severe pain, long duration of pain accompanied by blood pressure fluctuation and pulse change;
the effect is shown: the pain grade is raised by more than 2 grades, or reaches 0 degree;
the method has the following advantages: pain grade rose by 1 grade;
and (4) invalidation: no change or decrease in pain level;
the results of treatment for each group of patients are shown in table 1:
TABLE 1
| Group of | Show effect (human) | Effective (human) | Invalid (human) |
| Group 1 | 14 | 11 | 0 |
| Group 2 | 9 | 14 | 2 |
| Group 3 | 11 | 12 | 1 |
| Group 4 | 15 | 9 | 0 |
| Group 5 | 5 | 16 | 3 |
| Group 6 | 6 | 13 | 5 |
As can be seen from Table 1:
the traditional Chinese medicine composition prepared by the embodiment and the comparative example can effectively improve pain symptoms; compared with the existing commercial products, the composition prepared in example 3 has equivalent effect, and the traditional Chinese medicine composition prepared in example 3 has higher efficacy than the traditional Chinese medicine compositions prepared in other examples, especially the traditional Chinese medicine composition prepared in the comparative example.
Typical cases are as follows:
ankle arthritis disease example 1
A certain plum is male and 31 years old, has a medical history of ankle joint pain for several years, the pain degree is moderate pain, the pain can be felt in a resting state, the pain is intensified during activity, and normal rest is influenced;
the Chinese medicinal composition of the embodiment 3 is applied for treatment according to the method in the experimental example, and the pain symptom is relieved after 3 days of treatment and disappears after 7 days. The basic action is now normal.
Finger rheumatic arthritis disease example 2
Wangzhi, male, age 57, has swelling and pain in finger joints for 7 years, the pain degree is mild pain, the patient does not feel pain when resting and moving in cold water, and local hospitals and other special hospitals for rheumatism have a plurality of hospitalizations, and the patient can be better but cannot stop taking the medicine after each hospitalization. The disease condition is aggravated in more than a year;
the traditional Chinese medicine composition in the embodiment 3 of the application is applied for treatment according to the method in the experimental example, the pain symptom is relieved after 5 days of treatment, and the pain basically disappears after about 10 days.
Lumbar disc herniation case 3
Li Shi, female, age 48, lumbago for several years, 3-4 lumbar vertebrae protrusion diagnosed in local hospital 3 years ago, pain degree is severe pain, pain is obvious in lying state, and pain can not be relieved without medicine;
the Chinese medicinal composition in the embodiment 3 of the application is applied for treatment by the method in the experimental example 7 days later, so that the grade I pain is achieved. The pain basically disappears after 10 days of treatment, and the movement is free.
Rheumatoid arthritis disease example 4
Somebody on sun, female, age 65, long-term leg joint pain, and local hospital diagnosed rheumatoid arthritis 5 years ago. The pain degree is moderate pain, the pain can be felt in a resting state, the pain is intensified during movement, the normal rest is influenced, the pain can not be relieved without medicines, and the symptoms relapse after the medicines are stopped;
the Chinese medicinal composition of the embodiment 3 is applied for treatment according to the method in the experimental example, and the pain symptom is relieved after 5 days of treatment and disappears after 10 days. The basic action is now normal.
Knee joint hyperosteogeny case 5
Yang is a certain, female, age 49. The knee joint hyperosteogeny is progressively aggravated after walking inconvenience in 2012, is diagnosed as the knee joint hyperosteogeny by an X-ray film of a county traditional Chinese medicine hospital, the symptoms are improved after half a year of medical and physical treatment in the traditional Chinese medicine hospital, but the symptoms are mild and serious, the treatment effect is not obvious when the traditional Chinese medicine hospital is used for treating the hyperosteogeny in Zhengzhou and unsealing a plurality of hospitals, and the treatment is abandoned later.
When the treatment is introduced to our place by the same village people in the near-day period, the walking is performed with left shaking and right swinging, and the walking is difficult, the Chinese medicinal composition of the embodiment 3 is applied according to the method in the experimental example, the pain symptom is relieved after 5 days of treatment, and the pain symptom disappears after 10 days. The basic action is now normal. The pain symptom disappears after 10 days, and the hyperplastic part is obviously reduced through X-ray diagnosis. The existing method can freely walk, and the joints have no pain symptoms.
Osteoarthritis disease example 6
Wangzhi, male, age 67. Thirty years ago, the left knee joint is injured inadvertently during the working period of the local delivery company, the patella is torn and fractured, the left knee joint is obviously painful in 2000 years, the knee joint is confirmed to be hyperosteogeny through X-ray examination, the intercondylar ridge and the posterior upper and lower parts of the patella have hyperplasia period shadows, and the joint space is narrowed. The symptoms are relieved by adopting the treatments of transfusion, physical therapy, traction, moxibustion and the like in a plurality of hospitals, and the daily housework can be reluctantly operated.
The Chinese medicinal composition of the embodiment 3 is applied according to the method in the experimental example for treatment, so that the pain symptom is relieved after 5 days of treatment and disappears after 15 days. Now the basic action is normal.
Case 7
One certain piece, woman, age 42. In 2011, sudden lumbar pain and limited spinal motion were observed, and the lumbar 5 sacral 1 intervertebral disc prolapse and degeneration, physiological curvature disappeared, spinal canal stenosis and hyperosteogeny were confirmed in local hospitals and X-ray films. The treatment of many hospitals, physiotherapy, traction, acupuncture, medicine taking and the like can be comprehensively carried out for two or half years, the effect is not ideal, the patient is light and heavy, the patient is inconvenient to walk, even the patient lies in bed for rest, and the patient cannot take care of the life.
The diagnosis is achieved at the same place in the near days, the syndrome differentiation of the traditional Chinese medicine is caused by the invasion of three pathogenic factors of wind, cold and dampness into the channels and collaterals, and the treatment is preferably realized by warming the channels for dispelling cold, dispelling wind and removing dampness through the traditional Chinese medicine external treatment method. The traditional Chinese medicine composition in the embodiment 3 is applied according to the method in the experimental example, pain symptoms are initially relieved after 3 days of treatment, and the pain symptoms are obviously relieved after 10 days. Now the basic action is normal.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the embodiments of the present invention, and they should be construed as being covered by the appended claims and their equivalents.
Claims (10)
1. A traditional Chinese medicine composition for external use for promoting blood circulation, removing obstruction in channels, warming channels and relieving pain is characterized by being prepared from the following raw materials in parts by weight:
1000 to 2000 portions of common monkshood mother root, 1000 to 2000 portions of kusnezoff monkshood root, 1000 to 1200 portions of nux vomica, 800 to 1000 portions of clematis root, 700 to 900 portions of pubescent angelica root, 700 to 900 portions of incised notopterygium rhizome, 600 to 900 portions of Chinese angelica, 600 to 900 portions of safflower, 600 to 900 portions of Szechuan lovage rhizome and 500 to 900 portions of corydalis tuber.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight:
1800 parts of common monkshood mother root, 1500 parts of kusnezoff monkshood root, 1500 parts of nux vomica, 1000 parts of clematis root, 800 parts of doubleteeth pubescent angilica root, 760 parts of incised notopterygium rhizome, 690 parts of Chinese angelica, 650 parts of safflower, 630 parts of szechuan lovage rhizome and 600 parts of corydalis tuber.
3. The traditional Chinese medicine composition as claimed in claim 1, wherein the raw materials further comprise borneol and laurocapram.
4. A method for preparing the Chinese medicinal composition of any one of claims 1 to 3, which comprises the following steps:
(a) Mixing radix Aconiti, radix Aconiti Kusnezoffii, semen Strychni, radix Clematidis, radix Angelicae Pubescentis, notopterygii rhizoma, radix Angelicae sinensis, carthami flos, rhizoma Ligustici Chuanxiong and rhizoma corydalis to obtain a mixture;
(b) Soaking the mixed materials in ethanol, filtering, and collecting filtrate and residue;
(c) Leaching the filter residue by using ethanol to obtain a leachate;
(d) Mixing the filtrate and the leakage solution, adding Borneolum Syntheticum and laurocapram, and mixing to obtain the Chinese medicinal composition.
5. The method of claim 4, wherein in step (a), the mesh size of the mixed material is not less than 20 mesh.
6. The method according to claim 4, wherein in the step (b), the mass ratio of the mixed material to the ethanol is 1: 2-4.
7. The preparation method according to claim 4, wherein in the step (b), the soaking temperature is normal temperature and the soaking time is 5-7 days.
8. The method according to claim 4, wherein the mass of ethanol used in the step (c) is 2 to 4 times of the mass of the mixture.
9. The method according to claim 4, wherein the content of borneol added in step (d) is 0.3-0.6%.
10. The preparation method according to claim 4, wherein in the step (d), the addition content of laurocapram is 0.1-0.2%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211266279.9A CN115487230A (en) | 2022-10-17 | 2022-10-17 | A topical Chinese medicinal composition for promoting blood circulation, dredging collaterals, warming channels and relieving pain, and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211266279.9A CN115487230A (en) | 2022-10-17 | 2022-10-17 | A topical Chinese medicinal composition for promoting blood circulation, dredging collaterals, warming channels and relieving pain, and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115487230A true CN115487230A (en) | 2022-12-20 |
Family
ID=84474153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211266279.9A Pending CN115487230A (en) | 2022-10-17 | 2022-10-17 | A topical Chinese medicinal composition for promoting blood circulation, dredging collaterals, warming channels and relieving pain, and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115487230A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116870054A (en) * | 2023-08-03 | 2023-10-13 | 华中科技大学同济医学院附属同济医院 | Traditional Chinese medicine composition, application, gel and preparation method of gel |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110420250A (en) * | 2019-08-23 | 2019-11-08 | 陈家静 | A kind of Chinese medicine preparation and preparation method thereof for treating rheumatism and damage slight illness |
| CN112641859A (en) * | 2020-10-15 | 2021-04-13 | 郭淑一 | Blood circulation promoting, blood stasis removing and pain relieving ointment and preparation method thereof |
-
2022
- 2022-10-17 CN CN202211266279.9A patent/CN115487230A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110420250A (en) * | 2019-08-23 | 2019-11-08 | 陈家静 | A kind of Chinese medicine preparation and preparation method thereof for treating rheumatism and damage slight illness |
| CN112641859A (en) * | 2020-10-15 | 2021-04-13 | 郭淑一 | Blood circulation promoting, blood stasis removing and pain relieving ointment and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116870054A (en) * | 2023-08-03 | 2023-10-13 | 华中科技大学同济医学院附属同济医院 | Traditional Chinese medicine composition, application, gel and preparation method of gel |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102488869B (en) | Traditional Chinese medicinal external-use liniment for muscle and bone ache | |
| CN100544752C (en) | Ointment for orthopedics | |
| CN104398603A (en) | Chinese herbal medicinal hot compress treatment bag for lumbar vertebra, lumbar vertebra and leg joints, and use method thereof | |
| CN105982976B (en) | Treat bone penetrating fluid of bone and joint diseases and preparation method thereof | |
| CN106581454A (en) | Chinese herbal medicinal composition for treating bone fracture and disorders of the neck, shoulders, loin and legs, and preparation method thereof | |
| CN100528194C (en) | Medicine for treating femoral head necrosis | |
| CN101129640A (en) | Medicine for reliving inflammation and pain | |
| CN100534480C (en) | Bone-setting medicine and preparation method thereof | |
| CN115487230A (en) | A topical Chinese medicinal composition for promoting blood circulation, dredging collaterals, warming channels and relieving pain, and its preparation method | |
| CN101322786B (en) | External-use medicament for treating bone fracture and traumatic injury | |
| CN110227117A (en) | It is a kind of to treat osteoproliferation, pharmaceutical composition of lumbocrural pain and preparation method thereof | |
| CN110339325A (en) | A kind of exterior-applied medical wine and preparation method thereof for treating rheumatism | |
| CN102872362B (en) | Traditional Chinese medicine for treating chronic cholecystitis | |
| CN102008564B (en) | Externally applied medicine for treating hyperosteogeny and ache | |
| CN106215051A (en) | A kind of Chinese and Western compound medicine treating peripheral nerve injury and preparation method | |
| CN102743440B (en) | Traditional Chinese medicines for treating femoral head necrosis | |
| CN101502604B (en) | Chinese herbal medicine preparation for treating rheumatism | |
| CN112569301A (en) | External application plaster for treating neck, shoulder, waist and leg pain | |
| CN111329921A (en) | Traditional Chinese medicine composition for treating arthralgia and myalgia as well as medicine, preparation method and application thereof | |
| CN107582781A (en) | A kind of Externally applied Chinese medicine wax moxibustion for treating lumbar vertebra disease | |
| CN103550446A (en) | Traditional Chinese medicine composition for external use to treat rheumatoid arthritis and application of traditional Chinese medicine composition | |
| CN102357130B (en) | Chinese herbal medicine composition for treating rheumatism | |
| CN115006473B (en) | Traditional Chinese medicine wine for treating arthralgia and preparation method thereof | |
| CN106491938A (en) | A kind of Chinese medicine composition for the proliferation of mammary gland | |
| CN104001082A (en) | Traditional Chinese medicine for treating damp-heat stasis type kidney calculi |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |