CN1052637C - Application of Ranunculus japonicus - Google Patents
Application of Ranunculus japonicus Download PDFInfo
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- CN1052637C CN1052637C CN93111414A CN93111414A CN1052637C CN 1052637 C CN1052637 C CN 1052637C CN 93111414 A CN93111414 A CN 93111414A CN 93111414 A CN93111414 A CN 93111414A CN 1052637 C CN1052637 C CN 1052637C
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- Medicines Containing Plant Substances (AREA)
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Abstract
The invention relates to application of a herbal preparation, in particular to application of a ranunculus japonicus preparation. The preparation is prepared by boiling the whole plant of the ranunculus plant of ranunculus of Ranunculaceae with water and precipitating with ethanol, the ranunculus injection is a yellow-brown clear liquid, each milliliter of the injection is equivalent to 1 g of dry ranunculus, animal toxicity tests show that the ranunculus injection does not show toxicity, and 1058 cases of clinical treatment results show that the pain point injection of the ranunculus injection treats hyperosteogeny, the cure rate is more than 85 percent, the total effective rate is more than 98 percent, and the preparation also has obvious microcirculation improvement effect and no adverse effect on other physiological functions, thereby being an ideal analgesic and anti-inflammatory preparation.
Description
The present invention relates to a kind of application of herbal medicinal product, concrete is the application of Herba Ranunculi Japonici preparation.
Osteoproliferation disease and neck, shoulder, waist, skelalgia disease are a kind of commonly encountered diseases, frequently-occurring disease, and domestic investigation accounts for 1/2～1/4 of Orthopaedics Clinic sum, and peasant's sickness rate is 10.5～41%, and industrial and mineral worker's sickness rate is up to 41.3～60%.To this class treatment of diseases, the medicine that uses is the medicine that belongs to the treatment osteoproliferation disease at present, as spur and pain relieving liquid, bony spur tablet, the bone celestial being, the resisting hyperosteogeny sheet, JINGFUKANG, ZHUANGGU GUANJIE WAN, the piroxicam sheet, benorylate, somedon, GUNING ZHUSHEYE and Chinese herbal medicine external application and physical therapy or the like, the said medicine major part is oral agents and liniment, therefore must enter pain spot or enter pain spot through after the absorption of intestines and stomach by dermal osmosis, therefore certainly will influence like this-the part curative effect, develop and a kind ofly directly act on pain spot and medicine evident in efficacy then is a purpose of the present invention.
The technical scheme of finishing the foregoing invention task is: the herb of Ranunculaceae ranunculus Herba Ranunculi Japonici is processed into a kind of injection for the treatment of hyperosteogeny through the decocting in water alcohol deposition method, the Herba Ranunculi Japonici injection is a kind of clear liquid of yellowish-brown, it is the sterile water solution that the Herba Ranunculi Japonici herb is made through extraction, the solution pH value is 5.0～6.5, generate phenylhydrazone with the 2.4-dinitrophenylhydrazine reaction, under alkali condition, show red, the preparation of Herba Ranunculi Japonici injection is to add decocting in water twice earlier to fry in shallow oil, the water cooking liquid concentrating under reduced pressure, concentrated solution twice adding successively 95% ethanol is removed impurity, regulate about pH to 7, add the water for injection dilution behind the active carbon of adding 0.2%, stir filtration through refluxing, filtrate adds 2% benzyl alcohol, adds behind the injection dilute with water again through stirring again, fine straining, embedding and sterilization form.
Be described in further detail the present invention below.
The Herba Ranunculi Japonici injection is the sterile water solution that the Herba Ranunculi Japonici herb is made through extraction, every milliliter of suitable Herba Ranunculi Japonici 1g of injection.Herba Ranunculi Japonici is the Ranunculaceae ranunculus, Latin formal name used at school Ranuclus Japcnicus Thunb, and relevant pharmacopeia record, Herba Ranunculi Japonici nature and flavor suffering, little hardship, temperature, poisonous, tool antiinflammatory, analgesia, blood circulation promoting and blood stasis dispelling function cure mainly neck-shoulder pain, lumbago and leg pain and bone matrix hyperplasia.But the successive dynasties physician only does external, makes skin foaming, in order to diseases such as treatment malaria, malignant boil carbuncle pain, hepatitis, knee-joint pain, but all adopts the method for external application.
Recent studies shows that Herba Ranunculi Japonici contains eryside, when plant tissue was destroyed, eryside was wherein resolved into intensive protoanemonin by the ferment effect, and protoanemonin is easy to aggregate into Anemonin and loses its chemical toxicity, but its low concentration aqueous solution is stable, and structural formula is
CH＝CH
CH
2＝C
0-C＝0。Experiment shows that protoanemonin has very strong antibacterial action, and staphylococcus, streptococcus, diphtheria corynebacterium are had inhibitory action, Mlc is 1,12500, and tubercule bacillus is also had inhibitory action, Mlc is 1,50000, simultaneously escherichia coli is also had similar bacteriostasis.Pharmacological research proves that Herba Ranunculi Japonici has tangible analgesia and antiinflammatory action, and does not have the side effect of aspirin and glucocorticoid medicine, is more satisfactory analgesia and anti-inflammatory preparation.
The Herba Ranunculi Japonici injection is that the Herba Ranunculi Japonici herb is removed impurity in the lixiviating solution with flooding reuse ethanol earlier, behind the adjusting pH value, adds 2% benzyl alcohol again, and sterilization is at last made.
Concrete preparation technology is as follows: take by weighing dry Herba Ranunculi Japonici herb 100g, remove silt, clean twice of decocting in water, each about 1 hour, merge water cooking liquid twice, be evaporated to 1000ml, add 95% ethanol in the concentrated solution, make and contain alcohol amount and reach 65%, place 24 hours after-filtration, filtrate recycling ethanol is not to there being the alcohol flavor, and it is 2% lime cream that this concentrated solution adds concentration, regulate pH to 11, place after 1 hour, regulate pH to 5 with concentrated sulphuric acid, 24 hours after-filtration are placed in cold preservation, filtrate adds 95% ethanol, make pure content reach 75%, cold preservation was placed 24 hours, and filtered and recycled ethanol is to there not being the alcohol flavor.Filtrate is regulated about pH value to 7 with 20% sodium hydroxide, adds active carbon 2g, adds water for injection to 900ml, refluxes and stirs 30 minutes, filter, filtrate adds benzyl alcohol 20ml, adds water for injection again to 1000ml, fully stirs, fine straining, embedding, 100 ℃ of temperature conditions were sterilized 30 minutes down.
The Herba Ranunculi Japonici injection is a kind of clear liquid of yellowish-brown, pH value is 5.0～6.5, discrimination method is for adding the benzole soln 1ml of benzene-acetic acid (16: 4) 0.5ml and 0.05% 2.4-dinitrophenylhydrazine in 1ml Herba Ranunculi Japonici injection, the methanol solution 7.5ml that adds 80% potassium hydroxide after 1 hour produces red.
Animal toxicity test shows through Hunan Medical University, and the Herba Ranunculi Japonici injection does not show toxicity to animal safety.With 30 of purebred SD rat, male and female half and half, divide routine dose, 25 multiple doses, 3 groups of processing of 50 multiple doses and normal saline solution to compare every group of 20 rat.Medication group lumbar injection Herba Ranunculi Japonici liquid every other day once performs record every day and observes.Medication two months, medication group and matched group relatively, observe appetite, drinking-water, feces, body weight, hair skin, emotion, dynamically, growth and peripheral hemogram there is no difference; Electrocardiogram is no abnormal, puts to death and gets liver, the also no abnormal discovery of nephridial tissue cut sections for microscopic examination (see Table 1,2,3,4,5,6,7 and see the literary composition back)
Therapeutic Method: the patient except that pressing the orthopaedics routine physical examination, body surface pressure pain point that the emphasis inspection is relevant with disease location or tenderness district, and treat according to check result.Select pain spot 1-5 at every turn, every day or treatment every other day once, 10 times is a course of treatment, each every pain spot or drug for point amount are 0.5～3ml, escalated dose gradually, one time total amount is no more than 6ml.The inserting needle depth is decided on the injection site, generally gos deep into flesh floor 2～3cn with No. 7 syringe needles and gets final product.But the position that adiposis patient and pathological changes are darker then needs the long special-purpose injection needle with 10cm, and needle point is a purpose to reach diseased region.Thrust behind the skin slowly inserting needle, observe the inquiry patient reaction simultaneously, with the sense of expanding for well.As numb, electric shock or sensation of pricking appear, should stop inserting needle, and needle point is retreated, the slowly injection of pumpback depletion of blood.Should note not injuring internal organs, nerve, nerve trunk and blood vessel during injection.
The clinical treatment result of 1058 routine hyperosteogeny cases shows that Herba Ranunculi Japonici injection pain spot injection for curing is not found toxicity, and clinical cure rate is 86.1%, and total effective rate is 98.3%, and concrete grammar and result are as follows:
1. the basic condition of case sees Table 5 with treatment is inferior.
2. clinical efficacy sees Table 6.
Late result observation through 6 months to 17 years, 46 case recurrences among the healing person, relapse rate is 5%.Wherein 11 examples of recurrence account for 1% in 6 months, and mostly are heavy burden or the recurrence of tired back, do not have obvious relation with weather, sex, age, the course of disease.
3. the therapeutic effect with the GUNING ZHUSHEYE comparison sees Table 7.
GUNING ZHUSHEYE has antiinflammatory, analgesic activity, cures mainly hypertrophy joint disease and rheumatism, rheumatoid arthritis etc.The clinical random packet that relatively adopts, the double-blind trial method is respectively got 50 cases.Two groups are all adopted pain spot injection, treatment every other day once, treat 20 times continuously after check.
Two groups of results are through X
2Check P＜0.001, difference is extremely remarkable.
4. the paired observation before and after the treatment of 30 cases (check after treating 10 times), this therapy all has no adverse effects to patient's electrocardiogram, liver function, renal function, routine blood test, platelet, routine urinalysis.Acra is circular test a little not, and 30 examples are former all to exist light, moderate microcirculation disturbance, controls back 21 examples and recovers normal, and 7 examples are improved, and 2 examples do not have and change.
5. model case
Example 1: poplar, man 50 years old, first visit on June 5 in 1981.Right upper arm and cervical region distending pain three months, aggravation gradually, persistence, right upper extremity is weak to not holding chopsticks having a meal.The cerebral arteriosclerosis history is arranged.Taking Chinese medicine and western medicine, massage, physical therapy does not imitate.Health check-up: cervical vertebra does not have obvious deformity, stretch pain behind the neck and increase the weight of, about revolve slightly limited, anteflexion not hindering.Right upper arm is not red and swollen, and is of flaccid muscles, slight atrophy, and the extensive tenderness of deep layer and do not have fixedly pain spot, string two, triceps reflexes go down, and grip obviously reduces than the left side.Intervertebral foramina compression test (+), brachial plexus distraction test (+).X-ray film: the visible slight hyperosteogeny of neck 2-7 vertebral body trailing edge, obvious with lower edge behind neck 4 vertebral bodys especially, and outstanding in intervertebral foramina, this intervertebral foramina slightly is out of shape, but dwindles not obviously, each appendix of vertebra is normal.Diagnosis: hyperosteogeny of cervical vertebra, right arm clump neuralgia.Treatment: get behind the neck totally 3 on the other right side of the 4th vertebra and right upper arm pressure pain point, with the injection of Herba Ranunculi Japonici liquid pain spot, every other day once.Treat altogether 10 times, the symptom complete obiteration, the upper arm two, triceps reflexes and Myodynamia recovery are normal.Intervertebral foramina compression test (one), brachial plexus distraction test () is compeled the 10 years stable curative effect in room.
Example 2: the week certain, man, 50 years old, further consultation on January 3 in 1987.Diffusing property of lumbago companion right lower extremity pain 7 months.Had waist to be injured the right lower extremity history of pain in 75 years, X-ray film is diagnosed as waist 4,5 prolapse of intervertebral disc, waist 2-5 vertebral body hyperosteogeny, and 7 wheat harvesting periods of being in hospital, multi-treatment is invalid, uses 10 recoveries from illness of Herba Ranunculi Japonici liquid pain spot injection instead, stablizes 11 years not pains.This time morbidity is to lift weight in June, 86, hears that waist has rung, and next day, waist severe pain increased the weight of when diffusing property of companion's right lower extremity pain, cough, stool.Successively live certain hospital, certain sanatorium, take Chinese medicine and western medicine, physical therapy, massage, acupuncture, no obvious curative effects.In many ways contact seeks institute, names and will use Herba Ranunculi Japonici liquid pain spot injection for curing.Health check-up: overcautious gait, waist is lateral bending left, can not put down for sleeping in.The waist activity, lumbosacral joint test (+), ilium sacrum joint test (-), right 35 ° of straight-leg raising test, 85 ° on a left side, right side Lasegue's sign (+), feel to go down in the right leg outside and the foot outside, a little less than the big toe dorsiflex power, Achilles tendon reflex weakens, the other right side radioactivity tenderness (+) of lumbar vertebra 4-5, and waist 4 spinous process take over.X-ray film: go up lower edge and the slight hyperosteogeny of left and right sides edge before the waist 2-5 vertebral body, wide preceding narrow behind the lumbar vertebra 4-5 gap, it is straight that the physiology lordosis becomes.Diagnosis: hypertrophic spondylitis, prolapse of intervertebral disc, right sciatic nerves pain.Treatment: refer to examine lumbar vertebra 4-5 right side and find 5 of pressure pain points along diffusing property of right lower extremity sciatic nerve pain district, do the pain spot injection, treatment is every other day once treated transference cure 15 times altogether.The waist mobility, lumbosacral joint test (), right 85 ° of straight-leg raising test, original positive sign all disappears, and recovers normally work.Compel to visit 4 years stable curative effect.
With the osteoproliferation disease patient of this preparation for treating is poor effect and the Herba Ranunculi Japonici injection pain spot injection for curing of migrating after the additive method treatment earlier more than 90%.Herba Ranunculi Japonici injection excellent curative is analgesia, antiinflammatory and the function of promoting blood circulation to disperse blood clots of Herba Ranunculi Japonici on the one hand, the more important thing is that the Herba Ranunculi Japonici injection is to get the pain spot injection, medicine is concentrated through lesion, absorb without intestines and stomach, having overcome medicine is decomposed and the dispersive disadvantage of the efficacy of a drug by liver, also overcome the defective that outer coating method messenger drug power stops the skin shallow-layer, so curative effect is reliable rapidly; Part scholar thinks that acute injury, chronic strain and aseptic inflammation are former factors of osteoproliferation disease, and the later stage is because soft tissue adhesion in various degree; Fibrosis or cicatrixization, can stimulate or the pressuring nerve end slightly with the little blood vessel of nutrition, cause the local metabolic obstacle, make that the pain increased; And the obvious analgesic activity of Herba Ranunculi Japonici injection is because the Herba Ranunculi Japonici injection can make local little vasodilation, improve local nutrition supply, quicken metabolism by remarkable microcirculation improvement, thereby makes transference cure.
Make syrup, powder, liniment etc. with the Herba Ranunculi Japonici herb analgesic activity is also all arranged.
Herba Ranunculi Japonici injection pain spot injection for curing hyperosteogeny is not found toxicity, and clinical cure rate is more than 85%, total effective rate is more than 98%, also having the effect of significant microcirculation improvement simultaneously, and other physiological functions are had no adverse effects, is a kind of ideal analgesia and anti-inflammatory preparation.
Table 1, Herba Ranunculi Japonici injection are to the influence of rat food-intake
| Per 10 days per average daily amts (g) | ||||||
| Group | 1-10 days | 11-20 days | 21-30 days | 31-40 days | 41-50 days | 51-60 days |
| Heavy dose of group (40 times of amounts) | ????12.5 | ????16.8 | ????14.9 | ????25.4 | ????12.4 | ????26.3 |
| Middle dosage group (20 times of amounts) | ????11.9 | ????20.3 | ????16.2 | ????26.5 | ????15.3 | ????27.6 |
| Small dose group (therapeutic dose) | ????11.8 | ????18.1 | ????21.1 | ????26.4 | ????13.1 | ????24.4 |
| Matched group (normal saline) | ????13.1 | ????18.5 | ????17.9 | ????25.3 | ????15.3 | ????26.8 |
Table 2 Herba Ranunculi Japonici injection is to the influence of rat heart rate
| Group | ???n | Heart rate (% ± SD) | ??????P |
| Heavy dose of group | ??10 | ????390.9±25.6 | ????＞0.05 |
| Middle dosage group | ??11 | ????409.8±46.3 | ????＞0.05 |
| Small dose group | ??10 | ????378.8±19.3 | ????＞0.05 |
| Matched group | ??11 | ????368.3±31.3 |
Table 3 Herba Ranunculi Japonici injection is to the influence of rat weight increase number
| Group | ???????n | Weight increase number (% ± SD) (g) | ??????P |
| Heavy dose of group | ????♀9???♂11 | ????72.8±15.42 | ????＞0.05 |
| Middle dosage group | ????♀10??♂10 | ????72.25±14.37 | ????＞0.05 |
| Small dose group | ????♀9???♂10 | ????78.25±16.08 | ????＞0.05 |
| Matched group | ????♀11??♂9 | ????67.6±19.1 |
Table 4 Herba Ranunculi Japonici injection is to the influence of rat peripheral hemogram (X ± SD)
Annotate: three groups all with matched group than F＞0.05
| Group | ??n | ???????Hb | ????????WBC | ???????L(％) | ??????N(％) |
| Heavy dose of group | 20 | ????11.44±0.64 | ????1.81±0.37 | ????81.8±5.09 | ????15.2±5.09 |
| Middle dosage group | 20 | ????11.33±0.71 | ????1.80±0.30 | ????86.7±5.52 | ????13.3±5.52 |
| Small dose group | 20 | ????11.20±0.67 | ????1.75±0.47 | ????84.3±5.23 | ????15.7±5.23 |
| Matched group | 20 | ????11.75±0.62 | ????1.71±0.31 | ????86.27±4.83 | ????13.83±8.50 |
Table 5 basic condition
| Diseased region | The example number | Sex men and women | Age 18-30-40-50-60＞60 | The course of disease (a)＜1/2-2-5＞5 | Treat inferior＜5-10-20-30＞30 |
| Cervical vertebra | 508 | ?173?385 | ??25?96?147?132?108 | ????127?101?92?188 | ??51?114?152?126?85 |
| Lumbar vertebra | 412 | ?232?180 | ??32?66?131?123?60 | ????102?93??74?143 | ??41?82??125?112?52 |
| Other | 138 | ?71??67 | ??9??21??44??41??23 | ????34??28??25??51 | ??11?29??42??33??23 |
| Add up to | 1058 | ?476?582 | ??66?183?322?296?191 | ?263?222?191?382?103 | ??225?319?371?140 |
Table 6 clinical efficacy statistics
| Diseased region | The example number | Cure routine % | Produce effects example % | Effective routine % | Invalid routine % | Total effective routine % |
| Cervical vertebra | 508 | ????437?86.0 | ????47??9.3 | ????16??3.1 | ????8??1.6 | ????500???98.4 |
| Lumbar vertebra | 412 | ????358?86.9 | ????32??7.8 | ????15??3.6 | ????7??1.7 | ????405???98.3 |
| Other | 138 | ????116?84.0 | ????15??10.9 | ????4???2.9 | ????3??2.2 | ????135???97.8 |
| Add up to | 1058 | ????911?86.1 | ????94??8.9 | ????35??3.3 | ????18?1.7 | ????1040??98.3 |
Table 7 Herba Ranunculi Japonici injection and GUNING ZHUSHEYE are relatively
| Grouping | The example number | Cure routine % | Produce effects example % | Effective routine % | Invalid routine % | Total effective routine % |
| The Herba Ranunculi Japonici injection | 50 | ????26?52 | ????21?42 | ????3??6 | ????0??0 | ????50?100 |
| GUNING ZHUSHEYE | 50 | ????1??2 | ????5??10 | ????15?30 | ????19?38 | ????21?42 |
| Add up to | 100 | ????27?27 | ????26?26 | ????18?18 | ????19?19 | ????71?71 |
Claims (2)
1. the purposes of Herba Ranunculi Japonici is characterized in that making a kind of preparation for the treatment of hyperosteogeny of feedstock production with Herba Ranunculi Japonici.
2. the purposes of Herba Ranunculi Japonici as claimed in claim 1, the preparation method that it is characterized in that described Herba Ranunculi Japonici preparation is to get the Herba Ranunculi Japonici herb to make injection through the decocting in water alcohol deposition method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111414A CN1052637C (en) | 1993-05-21 | 1993-05-21 | Application of Ranunculus japonicus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93111414A CN1052637C (en) | 1993-05-21 | 1993-05-21 | Application of Ranunculus japonicus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1095611A CN1095611A (en) | 1994-11-30 |
| CN1052637C true CN1052637C (en) | 2000-05-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93111414A Expired - Fee Related CN1052637C (en) | 1993-05-21 | 1993-05-21 | Application of Ranunculus japonicus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1052637C (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102195533A (en) * | 2010-03-19 | 2011-09-21 | 林鸿祺 | Power conversion energy saving device, power supply system and generating method thereof |
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1993
- 1993-05-21 CN CN93111414A patent/CN1052637C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 《中药制剂汇编》第一版 1983.01.01 * |
| 《中药大辞典》第一版 1977.01.01 * |
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| Publication number | Publication date |
|---|---|
| CN1095611A (en) | 1994-11-30 |
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