CN104587209B - A kind of medicament for the treatment of sciatica - Google Patents
A kind of medicament for the treatment of sciatica Download PDFInfo
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- CN104587209B CN104587209B CN201510078609.5A CN201510078609A CN104587209B CN 104587209 B CN104587209 B CN 104587209B CN 201510078609 A CN201510078609 A CN 201510078609A CN 104587209 B CN104587209 B CN 104587209B
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Abstract
The present invention relates to a kind of medicament for the treatment of sciatica, it is made up of the material of following weight portion: the white stone 10-20 part in sea, Radix Dipsaci 5-15 part, Rhizoma Acori Graminei 10-20 part, Semen Brassicae Campestris 1-10 part, Herba Lycopodii 10-20 part, Rhizoma Chuanxiong 5-15 part, China winged euonymus 10-20 part, Radix Rhapontici 10-20 part, Folium Cae 10-20 part, Pheretima 10-20 part, broken leaf lotus 5-15 part, Olibanum 1-10 part, Pseudobulbus Coelogynes corymbosae 10-20 part, RADIX ET RHIZOMA LIGULARIAE 5-15 part, Radix Gentianae Macrophyllae 10-20 part, mountain Pericarpium Citri Reticulatae Viride 10-20 part, Radix Glycyrrhizae 1-10 part, Herba Ipomoeae Pes-Capraes 20-30 part, Fructus Chaenomelis 5-15 part, RADIX SALVIAE MILTIORRHIZAE 1-10 part, Radix Zanthoxyli Spinifolii 5-15 part, Radix Kadsurae longipedunculatae 5-15 part.Medicament of the present invention is based on dialectical treatment, and the clinical efficacy for the treatment of sciatica is definite, can improve the quality of life of patient, clinic application and popularization.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of medicament for the treatment of sciatica.
Background technology
Sciatica is clinical frequently-occurring disease, commonly encountered diseases, its refer to a variety of causes cause sciatic inflammation, edema thus there is radioactivity along (on rear side of waist, buttocks, thigh, after shank outside and foot outside etc.) in sciatic nerve path and institute distributed areas thereof, the sample that shocks by electricity, burn the clinical symptom group of sample pain.Modern is because of work and the impact of living habit, and ill ratio increases year by year, and sickness rate accounts for the first place of the various neuropathic of human body.According to incompletely statistics, just have 121 people's morbidities in approximately every 100,000 people, age of onset is many between 20 to 60 years old.Sciatica has feature that is long, that easily the recur course for the treatment of, and pain can be paroxysmal or persistence, and acute onset sharp ache, has a strong impact on work, quality of life.
The non-operative treatment of current western medical treatment sciatica generally adopts Adrenal Glucocorticoid or nonsteroidal anti-inflammatory analgetic.This symptom formula therapy only can alleviating pain, can not tackle the problem at its root, and there will be the side effect such as headache, dyspepsia, digestive tract ulcer, osteoporosis.And compare doctor trained in Western medicine, Chinese medicine make simple, to have no adverse reaction and cure rate is high, patient is easy to accept, and it is very necessary for therefore furtheing investigate based on traditional medicine sciatica and treat.
Summary of the invention
The object of this invention is to provide a kind of medicament for the treatment of sciatica.
In order to realize object of the present invention, the invention provides a kind of medicament for the treatment of sciatica, it is made up of the material of following weight portion: the white stone 10-20 part in sea, Radix Dipsaci 5-15 part, Rhizoma Acori Graminei 10-20 part, Semen Brassicae Campestris 1-10 part, Herba Lycopodii 10-20 part, Rhizoma Chuanxiong 5-15 part, China winged euonymus 10-20 part, Radix Rhapontici 10-20 part, Folium Cae 10-20 part, Pheretima 10-20 part, broken leaf lotus 5-15 part, Olibanum 1-10 part, Pseudobulbus Coelogynes corymbosae 10-20 part, RADIX ET RHIZOMA LIGULARIAE 5-15 part, Radix Gentianae Macrophyllae 10-20 part, mountain Pericarpium Citri Reticulatae Viride 10-20 part, Radix Glycyrrhizae 1-10 part, Herba Ipomoeae Pes-Capraes 20-30 part, Fructus Chaenomelis 5-15 part, RADIX SALVIAE MILTIORRHIZAE 1-10 part, Radix Zanthoxyli Spinifolii 5-15 part, Radix Kadsurae longipedunculatae 5-15 part.
Preferably, the medicament for the treatment of sciatica of the present invention is made up of the material of following weight portion: white 12 parts, the stone in sea, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 15 parts, Semen Brassicae Campestris 8 parts, Herba Lycopodii 12 parts, Rhizoma Chuanxiong 10 parts, magnificent winged euonymus 15 parts, Radix Rhapontici 15 parts, Folium Cae 12 parts, Pheretima 15 parts, broken 10 parts, leaf lotus, Olibanum 8 parts, Pseudobulbus Coelogynes corymbosae 12 parts, RADIX ET RHIZOMA LIGULARIAE 10 parts, Radix Gentianae Macrophyllae 12 parts, 15 parts, mountain Pericarpium Citri Reticulatae Viride, 8 parts, Radix Glycyrrhizae, Herba Ipomoeae Pes-Capraes 20 parts, Fructus Chaenomelis 10 parts, RADIX SALVIAE MILTIORRHIZAE 5 parts, Radix Zanthoxyli Spinifolii 12 parts, Radix Kadsurae longipedunculatae 10 parts.
More preferably, described medicament can be tablet, dispersible tablet, capsule, soft capsule or ointment.
The present invention also provides the purposes of compositions in the medicine of preparation treatment sciatica, described compositions is made up of the material of following weight portion: the white stone 10-20 part in sea, Radix Dipsaci 5-15 part, Rhizoma Acori Graminei 10-20 part, Semen Brassicae Campestris 1-10 part, Herba Lycopodii 10-20 part, Rhizoma Chuanxiong 5-15 part, China winged euonymus 10-20 part, Radix Rhapontici 10-20 part, Folium Cae 10-20 part, Pheretima 10-20 part, broken leaf lotus 5-15 part, Olibanum 1-10 part, Pseudobulbus Coelogynes corymbosae 10-20 part, RADIX ET RHIZOMA LIGULARIAE 5-15 part, Radix Gentianae Macrophyllae 10-20 part, mountain Pericarpium Citri Reticulatae Viride 10-20 part, Radix Glycyrrhizae 1-10 part, Herba Ipomoeae Pes-Capraes 20-30 part, Fructus Chaenomelis 5-15 part, RADIX SALVIAE MILTIORRHIZAE 1-10 part, Radix Zanthoxyli Spinifolii 5-15 part, Radix Kadsurae longipedunculatae 5-15 part.
Preferably, described compositions is made up of the material of following weight portion: white 12 parts, the stone in sea, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 15 parts, Semen Brassicae Campestris 8 parts, Herba Lycopodii 12 parts, Rhizoma Chuanxiong 10 parts, magnificent winged euonymus 15 parts, Radix Rhapontici 15 parts, Folium Cae 12 parts, Pheretima 15 parts, broken 10 parts, leaf lotus, Olibanum 8 parts, Pseudobulbus Coelogynes corymbosae 12 parts, RADIX ET RHIZOMA LIGULARIAE 10 parts, Radix Gentianae Macrophyllae 12 parts, 15 parts, mountain Pericarpium Citri Reticulatae Viride, 8 parts, Radix Glycyrrhizae, Herba Ipomoeae Pes-Capraes 20 parts, Fructus Chaenomelis 10 parts, RADIX SALVIAE MILTIORRHIZAE 5 parts, Radix Zanthoxyli Spinifolii 12 parts, Radix Kadsurae longipedunculatae 10 parts.
More preferably, described medicine can be tablet, dispersible tablet, capsule, soft capsule or ointment.
In the present compositions, Semen Brassicae Campestris, magnificent winged euonymus, broken leaf lotus are monarch drug; Hai Baishi, Herba Lycopodii, Folium Cae, Pseudobulbus Coelogynes corymbosae, RADIX ET RHIZOMA LIGULARIAE, mountain Pericarpium Citri Reticulatae Viride, Pheretima are ministerial drug; Radix Dipsaci, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Radix Rhapontici, Olibanum, Radix Gentianae Macrophyllae, Fructus Chaenomelis, RADIX SALVIAE MILTIORRHIZAE, Radix Zanthoxyli Spinifolii, Radix Kadsurae longipedunculatae, Herba Ipomoeae Pes-Capraes are adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for making medicine.
This disease name of sciatica is not had in ancient Chinese doctor nationality, but according to its pathological characters, should include in Chinese medicine be referred to as the category of " arthromyodynia ", " lumbago and skelalgia ", " sit buttocks wind ", " lower limb stock wind ", think that primary disease is many because of positive QI-insufficiency, interspaces of skin and muscles being loose, weakened defensive QI, the heresy of diseases caused by exogenous pathogenic factor wind, cold, wet, heat, cause muscle, muscles and bones, joint, obstruction of meridians and collaterals, QI-blood circulation is not smooth, stagnation of QI and blood may bring about pain.Medicament of the present invention, based on dialectical treatment, based on dredging the meridian, benefiting QI for activating blood circulation, is aided with invigorating the liver and kidney, bone and muscle strengthening, and the clinical efficacy for the treatment of sciatica is definite, clinic application and popularization.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modification that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
The preparation of embodiment medicament of the present invention
For ointment, the preparation technology of medicament of the present invention is as follows:
(1) white 120 grams, the stone in sea, Radix Dipsaci 100 grams, Rhizoma Acori Graminei 150 grams, Semen Brassicae Campestris 80 grams, Herba Lycopodii 120 grams, Rhizoma Chuanxiong 100 grams, magnificent winged euonymus 150 grams, Radix Rhapontici 150 grams, Folium Cae 120 grams, Pheretima 150 grams, broken 100 grams, leaf lotus, Olibanum 80 grams, Pseudobulbus Coelogynes corymbosae 120 grams, RADIX ET RHIZOMA LIGULARIAE 100 grams, Radix Gentianae Macrophyllae 120 grams, 150 grams, mountain Pericarpium Citri Reticulatae Viride, 80 grams, Radix Glycyrrhizae, Herba Ipomoeae Pes-Capraes 200 grams, Fructus Chaenomelis 100 grams, RADIX SALVIAE MILTIORRHIZAE 50 grams, Radix Zanthoxyli Spinifolii 120 grams, Radix Kadsurae longipedunculatae 100 grams is taken;
(2) Olibanum, Hai Baishi, mountain Pericarpium Citri Reticulatae Viride are ground into smalls, cross 120 mesh sieves, for subsequent use;
(3) Rhizoma Acori Graminei, Radix Rhapontici, Semen Brassicae Campestris, magnificent winged euonymus, Folium Cae, Radix Gentianae Macrophyllae, RADIX SALVIAE MILTIORRHIZAE are put into container, soak 2 hours in the dehydrated alcohol of 5000 milliliters, filter, make filtrate evaporate to dryness, pulverize;
(4) Radix Dipsaci, Herba Lycopodii, Rhizoma Chuanxiong, Pheretima, broken leaf lotus, Pseudobulbus Coelogynes corymbosae, RADIX ET RHIZOMA LIGULARIAE, Radix Glycyrrhizae, Herba Ipomoeae Pes-Capraes, Fructus Chaenomelis, Radix Zanthoxyli Spinifolii, Radix Kadsurae longipedunculatae are put into container, add 6000ml water, under the condition of backflow, heating 1 hour, filters, make filtrate evaporate to dryness, pulverize;
(5) ground product in combining step (2)-(4), adds 500 grams of lanolines, stirs, and is dispensed in 100 flexible pipes, obtains final product.
The curative effect of experimental example medicament of the present invention
1 data and method
1.1 physical data
This group sciatica patient is totally 100 examples.Diagnostic criteria is formulated with reference to " clinical disease diagnosis foundation and healing improvement standard " (Sun Chuanxing, People's Medical Officer Press, in June, 1998, the 2nd edition), specific as follows:
(1), along the radiated pain of sciatic nerve areal area, during radiculopathy, the actions such as cough, sneeze often make pain increase the weight of.For palliating a disease, spinal column often has lateral bending, and during bed, knee often has micro-song.
(2) pressure pain point is had along sciatic nerve areal area, as waist (side) point, ilium point, buttocks point, rouge point, diseased point, ankle point etc.
(3) sciatic nerve involves and levies the normal positive.
(4) motion in various degree, sensation, reflection and autonomic nerve obstacle is had within the scope of sciatic nerve domination.
(5) X takes the photograph sheet or CT or MRI and checks and do not find lumbar vertebra, bones of the body bone, bones of the body arthropathy.
100 routine patients are divided into treatment group 50 example and matched group 50 example.Wherein treatment group male 28 example, women 22 example; Patient age between 26-58 year, 41.2 years old mean age; The course of disease 8.1 ± 2.8 months.Matched group male 30 example, women 20 example; Patient age between 25-56 year, 39.8 years old mean age; The course of disease 7.9 ± 2.3 months.Two groups of patients are at the equal not statistically significant of the difference of sex, age, the course of disease (p > 0.05).
1.2 observation index
1.2.1 behavior pain determining (BRS-6, behavioral rating scale)
BRS-6 standards of grading are as follows:
Without pain 0 point
There is pain, but easily 1 point out in the cold
There is pain, cannot ignore, but do not affect daily life 2 points
There is pain, cannot ignore, disturbance of concentration 3 points
There is pain, cannot ignore, all daily life all effecteds, but basic physiological demand can be completed as feed etc. 4 points
Existence has an intense pain, and cannot ignore, and needs have a rest or lie up 5 points
1.2.2 pain rating index (PRI)
PRI scoring content comprises sensation item and emotion item.
Sensation item: jumping pain, twinge, pain of lancinating, sharp pain, spasm referred pain, angor, hot causalgia, lasting fixing pain, distending pain, tenderness, tearing pain.
Emotion item: weakness, be sick of, fear, endure hardships or punish sense.
Pain degree is divided into without (0 point), slight (1 point), moderate (2 points), severe (3 points) four grades, successively to above-mentioned every mark and add and, obtain total score.
1.3 Therapeutic Method
Treatment group uses the ointment of the present invention prepared in embodiment, 1 pipe ointment is smeared to affected part, 1 times/day, continuous administration 10 days.Matched group uses HUOXUE ZHITONG GAO (traditional Chinese medicines accurate word Z42021573,2010-09-30, Hubei Shu Ermaikang pharmaceutcal corporation, Ltd produces), 1 subsides/day, continuous administration 10 days.
1.4 criterion of therapeutical effect
Curative effect determinate standard is formulated as follows with reference to State Administration of Traditional Chinese Medicine's " disease of tcm diagnosis and criterion of therapeutical effect ":
Cure: lumbago and skelalgia disappears, leg raising straight more than 70 °, the extensive recovery operation of energy;
Effective: lumbago and skelalgia alleviates, waist movable function improves;
Invalid: symptom, sign are without improvement.
Effective percentage=(cure+effective) number of cases/total number of cases × 100%
1.5 statistical method
SPSS17.0 statistical software is adopted to carry out statistical procedures.Measurement data with
represent, adopt t inspection; Enumeration data compares employing x
2inspection.Think there is statistical significance with p < 0.05.
2 results
2.1 behavior pain determining (BRS-6) scorings
Before and after two groups of patient treatments BRS-6 mark score value change relatively in table 1.As can be seen from Table 1, two groups of patients score value not statistically significant before the treatment (p > 0.05), and after treating 10 days, the score value of two groups declines all to some extent, difference has statistical significance (p<0.05), and treatment group comparatively matched group decline more obvious, group difference has statistical significance (p<0.05).
The comparison of table 1 BRS-6 scoring score value change
Note: compare with before treatment, * p<0.05; Compare with matched group, * * p<0.05
2.2 pain rating indexs (PRI) are marked
Before and after two groups of patient treatments PRI mark score value change relatively in table 2.As can be seen from Table 2, two groups of patients score value not statistically significant before the treatment (p > 0.05), and after treating 10 days, the score value of two groups declines all to some extent, difference has statistical significance (p<0.05), and treatment group comparatively matched group decline more obvious, group difference has statistical significance (p<0.05).
The comparison of table 2 PRI scoring score value change
Note: compare with matched group, * p<0.05
2.3 clinical efficacy
Two groups of patient clinical curative effects relatively in table 3.Table 3 shows, and the difference of two groups of patient clinical curative effects has statistical significance (p<0.05).This shows that treatment group symptom takes a turn for the better and is better than matched group, and the clinical efficacy of medicament of the present invention is better than HUOXUE ZHITONG GAO.
Table 3 Clinical efficacy comparison
Note: compare with matched group, * p<0.05.
Claims (2)
1. treat the medicament of sciatica for one kind, it is characterized in that being made up of the material of following weight portion: the white stone 10-20 part in sea, Radix Dipsaci 5-15 part, Rhizoma Acori Graminei 10-20 part, Semen Brassicae Campestris 1-10 part, Herba Lycopodii 10-20 part, Rhizoma Chuanxiong 5-15 part, China winged euonymus 10-20 part, Radix Rhapontici 10-20 part, Folium Cae 10-20 part, Pheretima 10-20 part, broken leaf lotus 5-15 part, Olibanum 1-10 part, Pseudobulbus Coelogynes corymbosae 10-20 part, RADIX ET RHIZOMA LIGULARIAE 5-15 part, Radix Gentianae Macrophyllae 10-20 part, mountain Pericarpium Citri Reticulatae Viride 10-20 part, Radix Glycyrrhizae 1-10 part, Herba Ipomoeae Pes-Capraes 20-30 part, Fructus Chaenomelis 5-15 part, RADIX SALVIAE MILTIORRHIZAE 1-10 part, Radix Zanthoxyli Spinifolii 5-15 part, Radix Kadsurae longipedunculatae 5-15 part.
2. the medicament for the treatment of sciatica according to claim 1, it is made up of the material of following weight portion: white 12 parts, the stone in sea, Radix Dipsaci 10 parts, Rhizoma Acori Graminei 15 parts, Semen Brassicae Campestris 8 parts, Herba Lycopodii 12 parts, Rhizoma Chuanxiong 10 parts, magnificent winged euonymus 15 parts, Radix Rhapontici 15 parts, Folium Cae 12 parts, Pheretima 15 parts, broken 10 parts, leaf lotus, Olibanum 8 parts, Pseudobulbus Coelogynes corymbosae 12 parts, RADIX ET RHIZOMA LIGULARIAE 10 parts, Radix Gentianae Macrophyllae 12 parts, 15 parts, mountain Pericarpium Citri Reticulatae Viride, 8 parts, Radix Glycyrrhizae, Herba Ipomoeae Pes-Capraes 20 parts, Fructus Chaenomelis 10 parts, RADIX SALVIAE MILTIORRHIZAE 5 parts, Radix Zanthoxyli Spinifolii 12 parts, Radix Kadsurae longipedunculatae 10 parts.
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| CN201510078609.5A CN104587209B (en) | 2015-02-13 | 2015-02-13 | A kind of medicament for the treatment of sciatica |
| CN201510422350.1A CN104958559A (en) | 2015-02-13 | 2015-02-13 | Medicament for treating sciatica |
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Citations (4)
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|---|---|---|---|---|
| CN101259201A (en) * | 2008-04-21 | 2008-09-10 | 全光彪 | Antirheumatic pain relieving medicaments |
| CN101391063A (en) * | 2007-09-19 | 2009-03-25 | 秦汉富 | Health care medicinal liquor |
| CN103316298A (en) * | 2013-06-26 | 2013-09-25 | 柳晖 | Traditional Chinese composition for treating arthralgia |
| CN103721080A (en) * | 2013-12-31 | 2014-04-16 | 吴宝海 | Traditional Chinese medicine composition for treating cervical spondylosis, lumbar spondylosis and sciatica |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897821B (en) * | 2010-05-09 | 2012-06-13 | 姜红成 | Granular preparation for promoting blood circulation, dredging collaterals and relieving pain and preparation method as well as detection method thereof |
| CN103394031B (en) * | 2013-07-29 | 2015-05-20 | 亢廷英 | Medicament for treating sciatica |
| CN104940346A (en) * | 2014-07-12 | 2015-09-30 | 范巧兰 | Medicine for treating lumbar muscle strain accompanied by sciatica |
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2015
- 2015-02-13 CN CN201510422350.1A patent/CN104958559A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101391063A (en) * | 2007-09-19 | 2009-03-25 | 秦汉富 | Health care medicinal liquor |
| CN101259201A (en) * | 2008-04-21 | 2008-09-10 | 全光彪 | Antirheumatic pain relieving medicaments |
| CN103316298A (en) * | 2013-06-26 | 2013-09-25 | 柳晖 | Traditional Chinese composition for treating arthralgia |
| CN103721080A (en) * | 2013-12-31 | 2014-04-16 | 吴宝海 | Traditional Chinese medicine composition for treating cervical spondylosis, lumbar spondylosis and sciatica |
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| CN104587209A (en) | 2015-05-06 |
| CN104958559A (en) | 2015-10-07 |
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