CN108310163A - A kind of dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation and preparation method thereof - Google Patents
A kind of dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation and preparation method thereof Download PDFInfo
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- CN108310163A CN108310163A CN201810472919.9A CN201810472919A CN108310163A CN 108310163 A CN108310163 A CN 108310163A CN 201810472919 A CN201810472919 A CN 201810472919A CN 108310163 A CN108310163 A CN 108310163A
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Abstract
The invention discloses a kind of dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparations and preparation method thereof, belong to technical field of traditional Chinese medicines.Dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, raw material include following component：Sesame oil, yellow lead, scorpion, centipede, bovine insects, Chinese blister beetle, vomiting nut, huechys, zaocys dhumnade, leech, Eupolyphoge sinensis, earthworm, Radix Notoginseng, safflower, dragon's blood, frankincense, myrrh, camphor, borneol, Moschus, radix cyathulae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, monkshood, teasel root, the rhizome of davallia, the root of Chinese clematis, rosin, the tuber of pinellia, caulis sinomenii, anti-Qi, Cortex Eucommiae, radix aconiti agrestis；The Chinese medicine preparation of the present invention innovatively introduces bovine insects, Chinese blister beetle and huechys on the basis of traditional dispelling wind-evil and wetness-evil Huoxue Herbs vomiting nut, and the toxicity that can weaken vomiting nut is added in the joint of these three Chinese medicinal materials, while the effect of can also enhance vomiting nut；In addition, above-mentioned four kinds are used cooperatively with other adjuvants, wind-damp dispelling, the promoting blood circulation and removing blood stasis, work(removed obstruction in channels to relieve pain are played altogether.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, specifically, being related to a kind of dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation and its preparation
Method.
Background technology
In recent years in people's daily life, more and more rheumatic and rheumatoid arthritis, lumbar muscle strain, sclerotin
The patient of hyperplasia, cervical spondylosis, sciatica, scapulohumeral periarthritis etc. suffers all kinds of tormenting in pain.These patient's some are turned to any doctor one can find when critically ill,
Some has bought medicine, and the state of an illness is mitigated at that time, slightly pain in the same old way again later；Therefore, such issues that as patient a great problem,
Seriously annoying very much patient.
Rheumatism and rheumatoid disease are a kind of common clinical, frequently-occurring disease, and motherland's Traditional Chinese Medicine is referred to as " rheumatism ".The disease
Incidence is high, and easy recurrent exerbation, obstinate disease can cause heart and other internal organs lesions.It investigates and unites according to health ministry
Meter, every year because of rheumatism and the direct or indirect death toll of rheumatoid disease about 1,500,000 people.Currently, doctor trained in Western medicine controlling for the disease
The drug mostly used is treated based on antibiotic, hormone, analgesic, short run effect is fine, but is not easy to effect a radical cure, but takes for a long time not
But drug resistance is will produce, such as gastrointestinal function damage, osteoporosis, endocrine disturbance, nervous system disorders and skin are also will produce
The adverse reactions such as quality hyperfunction.
Lumbar muscle strain refers to the chronic injury of the soft tissues such as waist muscle, fascia and ligament, is most common in waist-leg pain
Disease, also known as functional pain in the back, chronic lower waist strain etc..This disease is apt to occur in adult, and clinical symptoms are waist or lumbosacral region pain
Bitterly, recurrent exerbation pain can climate change or tired degree and change, when weight when it is light, it is touching not to be cured.Currently, clinical treatment waist
There are many method of muscular strain, and anti-inflammation analgesic or operative treatment are taken in such as physical therapy, though there is certain curative effect, effect is all paid no attention to
Think.
Osteoproliferation is to lead to local joint, muscle, ligament moving obstacle with sclerotin pathological proliferation, based on the pain that occurs together
Want the disease of symptom.Cervical vertebra, lumbar vertebrae, joint and calcaneum etc., including hypertrophy rachitis, hpertrophic osteoarthropathy can be happened at
And calcaneal spur etc..This disease is apt to occur in 40 years old or more person in middle and old age and is engaged in load-bearing, stands long, the staff of sitting, with activity
The larger joint of range, the lesion of vertebra are common.Its cause of disease is unknown so far, belongs to the scope of senile retrogression pathological changes more.
Doctor trained in Western medicine uses non-hormone antiinflammation pain-stopping pharmaceutical, physical therapy and operative treatment at present, has certain effect to alleviating symptom, but so far still
Without special effective therapy.
Cervical intervertebral disk degenerative changes and its secondary pathological change involve its structures surrounding (nerve root, spinal cord,
Vertebral artery, sympathetic nerve etc.), and corresponding clinical manifestation person occur and be known as cervical spondylosis.Cervical spondylosis is Orthopedic Clinical common disease, more
Morbidity.Patient less serious case neck and shoulder brachialgia, dizziness and headache, severe one is in great pain or weakness of limbs, notably suddenly faints, seriously affects
People's health is lived.For cervical spondylosis, there are many therapies at present.Physical therapy have using various machineries traction treatment, by
It rubs therapy, thermotherapy, magnetic therapy etc., only local treatment, and cannot be adjusted on the whole, effect is not ideal enough；And treat
Drug is mostly externally applied drug, can only generally alleviate symptom；Although also there is medicine for oral administration, toxicity is big, unsuitable long term usage.
Scapulohumeral periarthritis is the chronic aseptic inflammation of the soft tissues such as shoulder joint Surrounding muscles, tendon, synovial bursa and capsular ligament.Inflammation
Lead to intra-articular outer adhesion, to influence the activity of shoulder joint.Onset mostly because of shoulder joint surrounding tissue, such as flesh thorax, synovial bursa by
Caused by freezing, wound, infection.Many patients are caused by rheumatism.Currently, the method for cure scapulohumeral periarthritis is more both at home and abroad,
Doctor trained in Western medicine mainly uses drug for congex, and Chinese medicine mainly uses veins and artery relieving pill, blood circulation promoting and pain relieving plaster etc., aches although can alleviate to patient
Bitterly, but really respite, and take for a long time and be easy to bring certain side effect to sufferer, Cure is pessimistic, is easy out
Now repeatedly, pain is brought to patient's body and mind, and increases medical expense.
Above-mentioned common chronic disease mostly invades channels and collaterals due to rheumatism chill, and blood is obstructed, not general rule pain, therefore sees swollen joint
Bitterly, then cause rheumatic arthritis, cervical spondylosis, lumbar muscle strain or scapulohumeral periarthritis etc..Current Chinese medicine therapy, mostly uses
The Chinese drugs agentia of dispelling wind-evil and wetness-evil promoting blood circulation, but relevant research is very few, and some Chinese medicines have toxicity, are not suitable for the long-term of chronic disease
Treatment.Chinese invention patent (application number：00107191.2, open notification number：CN 1277032A) disclose a kind of dispelling wind-evil and wetness-evil
Pain-easing plaster, by Herba Siegesbeckiae, frankincense, ginger, semen brassicae, root of Aucklandia lappa Decne, Chinese ephedra, Southern Star, Radix Angelicae Pubescentis, Radix Angelicae Sinensis, rheum officinale, rosin, Rhizoma Et Radix Notopterygii, open country
Suitable red lead and sesame oil is added in the compositions such as cotton, the root of Dahurain angelica, monkshood, caulis piperis futokadsurae, asarum, castor bean, to arthritis, shoulder
The illnesss such as inflammation, lumbar vertebra strain, sciatica, osteoproliferation pain all have special efficacy；Chinese invention patent (application number：
200810180677.2 open notification number：CN 101642494A) a kind of traditional Chinese powder medicine for treating rheumatic and rheumatoid is disclosed, by
Semen Strychni (processed), aconiti preparata,radix, Carapax Trionycis (processed), Xuancheng's pawpaw, radix cyathulae and safflower form in proportion；Preparation process is as follows：Screen each component
Medicinal material；Horse spleen ferrtin impregnated through 10 days, peeling, is sliced and dries, mix sand mixing, parch, again shakeout, crushing, sieving, is in
Powdery；It presses《Pharmacopeia》Specification processes monkshood, radix aconiti agrestis, turtle shell, Xuancheng's pawpaw, radix cyathulae and safflower, and through crushing, sieving to obtain fine powder；
Above-mentioned Six-element medicine is weighed by " equal increments method ", and it is uniformly mixed with Semen Strychni (processed) powder, is sieved；It quantitatively weighs, pack, print
Word.The medical instrument has tune negative and positive, and replenishing qi and blood, wind-damp dispelling, cold dispelling is evil, the function of migratory arthralgia analgesic, main treating rheumatic arthritis,
Strength lumbar vertebrae hypertrophy, osteoproliferation, lumbar disc prolapse, sciatica.
But the Chinese medicine preparation being mentioned in above-mentioned existing patent has the following problems：Vomiting nut has dispelling wind-evil and wetness-evil promoting blood circulation
Effect is usually used in the clinical treatment of rheumatism etc., but its toxicity (containing a large amount of alkaloid) is larger；In addition many dispelling wind-evil and wetness-evils
Although the Chinese medicine preparation of promoting blood circulation reduces the dosage of vomiting nut, or directly removes vomiting nut, its curative effect is poor.
Invention content
1, it to solve the problems, such as
For the problem that existing dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation toxic side effect is larger, the present invention, which provides one kind and chasing after wind, to dispel
Wet blood-activating Chinese medicine preparation and preparation method thereof, cure rate height, effect without recurrence and nontoxic pair may be implemented in it.
2, technical solution
To solve the above problems, the present invention adopts the following technical scheme that.
A kind of dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, in terms of parts by weight, raw material includes following component：
2487.5 parts -2512.5 parts of sesame oil, 1243.75 parts -1256.25 parts of yellow lead, 49.75 parts -50.25 parts of scorpion, Wu
49.75 parts -50.25 parts of centipede, 37.81 parts -38.19 parts of bovine insects, 37.81 parts -38.19 parts of Chinese blister beetle, 1492.5 parts of vomiting nut -
1507.5 parts, 37.81 parts -38.19 parts of huechys；
696.5 parts -703.5 parts of zaocys dhumnade, 696.5 parts -703.5 parts of leech, 696.5 parts -703.5 parts of Eupolyphoge sinensis, earthworm 597
- 603 parts of part, 597 parts -603 parts of Radix Notoginseng, 696.5 parts -703.5 parts of safflower, 398 parts -402 parts of dragon's blood, 497.5 parts of frankincense -
502.5 parts, 497.5 parts -502.5 parts of myrrh, 199 parts -201 parts of camphor, 199 parts -201 parts of borneol, 14.925 part -20.1 of Moschus
Part；
597 parts -603 parts of radix cyathulae, 796 parts -804 parts windproof, 796 parts -804 parts of Rhizoma Et Radix Notopterygii, 696.5 part -703.5 of Radix Angelicae Pubescentis
Part, 597 parts -603 parts of monkshood, 597 parts -603 parts of teasel root, 497.5 parts -502.5 parts of the rhizome of davallia, 597 parts -603 parts of the root of Chinese clematis, pine
597 parts -603 parts fragrant, 497.5 parts -502.5 parts of the tuber of pinellia, 497.5 parts -502.5 parts of caulis sinomenii, 597 parts -603 parts of anti-Qi, Cortex Eucommiae
149.25 parts -160.8 parts, 159.2 parts -180.9 parts of radix aconiti agrestis.
Preferably, the dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, in terms of parts by weight, raw material includes following component：
2494.8 parts -2509.5 parts of sesame oil, 1247 parts -1253 parts of yellow lead, 49.86 parts -50.05 parts of scorpion, centipede 49.75
- 50.25 parts of part, 37.9 parts -38.1 parts of bovine insects, 37.81 parts -38.19 parts of Chinese blister beetle, 1495 parts -1502.5 parts of vomiting nut, matchmaker
37.9 parts -38.1 parts of son；
698.5 parts -701.5 parts of zaocys dhumnade, 698.5 parts -701.5 parts of leech, 696.5 parts -703.5 parts of Eupolyphoge sinensis, earthworm 598
- 601 parts of part, 597 parts -603 parts of Radix Notoginseng, 697.5 parts -703.5 parts of safflower, 399 parts -401 parts of dragon's blood, 497.5 parts of frankincense -
502.5 parts, 498.5 parts -501.5 parts of myrrh, 199 parts -201 parts of camphor, 199 parts -201 parts of borneol, 16 parts -19 parts of Moschus；
598 parts -601 parts of radix cyathulae, 798 parts -802 parts windproof, 797 parts -803 parts of Rhizoma Et Radix Notopterygii, 696.5 part -703.5 of Radix Angelicae Pubescentis
Part, 597 parts -603 parts of monkshood, 597 parts -603 parts of teasel root, 498.5 parts -501.5 parts of the rhizome of davallia, 598 parts -603 parts of the root of Chinese clematis, pine
597 parts -603 parts fragrant, 498.5 parts -501.5 parts of the tuber of pinellia, 497.5 parts -502.5 parts of caulis sinomenii, 599 parts -602 parts of anti-Qi, Cortex Eucommiae
153 parts -157 parts, 165 parts -175 parts of radix aconiti agrestis.
Preferably, the dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, in terms of parts by weight, raw material includes following component：
2500 parts of sesame oil, 1250 parts of yellow lead, 50 parts of scorpion, 50 parts of centipede, 38 parts of bovine insects, 38 parts of Chinese blister beetle, vomiting nut
1500 parts, 38 parts of huechys；
700 parts of zaocys dhumnade, 700 parts of leech, 700 parts of Eupolyphoge sinensis, 600 parts of earthworm, 600 parts of Radix Notoginseng, 700 parts of safflower, dragon's blood 400
Part, 500 parts of frankincense, 500 parts of myrrh, 200 parts of camphor, 200 parts of borneol, 18 parts of Moschus；
600 parts of radix cyathulae, 800 parts windproof, 800 parts of Rhizoma Et Radix Notopterygii, 700 parts of Radix Angelicae Pubescentis, 600 parts of monkshood, 600 parts of teasel root, the rhizome of davallia
500 parts, 600 parts of the root of Chinese clematis, 600 parts of rosin, 500 parts of the tuber of pinellia, 500 parts of caulis sinomenii, 600 parts of anti-Qi, 155 parts of Cortex Eucommiae, radix aconiti agrestis 170
Part.
Preferably, the dosage form of the Chinese medicine preparation is pharmaceutically acceptable dosage form.
Preferably, the dosage form of the Chinese medicine preparation is powder, patch or ointment.
A kind of preparation method of dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, step include：
(1) by scorpion, centipede, bovine insects, Chinese blister beetle, vomiting nut, huechys, zaocys dhumnade, leech, Eupolyphoge sinensis, earthworm, Radix Notoginseng,
Safflower, radix cyathulae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, monkshood, teasel root, the rhizome of davallia, the root of Chinese clematis, rosin, the tuber of pinellia, caulis sinomenii, is prevented dragon's blood
Qi, Cortex Eucommiae, radix aconiti agrestis, which are added in sesame oil, to be impregnated -7 days 3 days, is then yellowish-brown with the color being boiled by fire to sesame oil, then
The dregs of a decoction in sesame oil are filtered out；
(2) then yellow lead is added in the sesame oil after step (1) Chinese medicine slag filters out, small fire is brewed into paste；Then cold
But to 38 DEG C -42 DEG C, the Moschus pulverized, frankincense, myrrh, camphor and borneol are put into, be uniformly mixed to get.
Preferably, 40 DEG C are cooled in step (2).
Above-mentioned dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation is in treatment rheumatic arthritis, cervical spondylosis, scapulohumeral periarthritis, lumbar muscle strain and bone
Application in matter hyperplasia may additionally serve for treatment rheumatoid arthritis, sciatica etc..
3, advantageous effect
Compared with the prior art, beneficial effects of the present invention are：
The Chinese medicine preparation of the present invention innovatively introduces ox on the basis of traditional dispelling wind-evil and wetness-evil Huoxue Herbs vomiting nut
Gadfly, Chinese blister beetle and huechys, the toxicity that can weaken vomiting nut is added in the joint of these three Chinese medicinal materials, while can also enhance
The effect of vomiting nut；In addition, above-mentioned four kinds are used cooperatively with other adjuvants, play altogether wind-damp dispelling, it is promoting blood circulation and removing blood stasis, remove obstruction in channels to relieve pain it
Work(.
Specific implementation mode
The present invention is further described below with reference to specific embodiment.
Embodiment 1
The dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation of the present embodiment, in terms of parts by weight, raw material includes following component：
2487.5 parts of sesame oil, 1243.75 parts of yellow lead, 49.75 parts of scorpion, 49.75 parts of centipede, 37.81 parts of bovine insects, Chinese blister beetle
37.81 parts, 1492.5 parts of vomiting nut, 37.81 parts of huechys；
703.5 parts of zaocys dhumnade, 703.5 parts of leech, 703.5 parts of Eupolyphoge sinensis, 603 parts of earthworm, 603 parts of Radix Notoginseng, safflower 703.5
Part, 402 parts of dragon's blood, 502.5 parts of frankincense, 502.5 parts of myrrh, 201 parts of camphor, 201 parts of borneol, 20.1 parts of Moschus；
597 parts of radix cyathulae, 796 parts windproof, 796 parts of Rhizoma Et Radix Notopterygii, 696.5 parts of Radix Angelicae Pubescentis, 597 parts of monkshood, 597 parts of teasel root, bone are broken
497.5 parts of benefit, 597 parts of the root of Chinese clematis, 597 parts of rosin, 497.5 parts of the tuber of pinellia, 497.5 parts of caulis sinomenii, 597 parts of anti-Qi, Cortex Eucommiae
149.25 parts, 159.2 parts of radix aconiti agrestis.
The preparation method of above-mentioned dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, step include：
(1) by scorpion, centipede, bovine insects, Chinese blister beetle, vomiting nut, huechys, zaocys dhumnade, leech, Eupolyphoge sinensis, earthworm, Radix Notoginseng,
Safflower, radix cyathulae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, monkshood, teasel root, the rhizome of davallia, the root of Chinese clematis, rosin, the tuber of pinellia, caulis sinomenii, is prevented dragon's blood
Qi, Cortex Eucommiae, radix aconiti agrestis, which are added in sesame oil, to be impregnated 3 days, is then yellowish-brown with the color being boiled by fire to sesame oil, then sesame oil
In the dregs of a decoction filtered out；
(2) then yellow lead is added in the sesame oil after step (1) Chinese medicine slag filters out, small fire is brewed into paste；Then cold
But to 38 DEG C, the Moschus pulverized, frankincense, myrrh, camphor and borneol are put into, be uniformly mixed to get.
Embodiment 2
The dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation of the present embodiment, in terms of parts by weight, raw material includes following component：
2512.5 parts of sesame oil, 1256.25 parts of yellow lead, 50.25 parts of scorpion, 50.25 parts of centipede, 38.19 parts of bovine insects, Chinese blister beetle
38.19 parts, 1507.5 parts of vomiting nut, 38.19 parts of huechys；
696.5 parts of zaocys dhumnade, 696.5 parts of leech, 696.5 parts of Eupolyphoge sinensis, 597 parts of earthworm, 597 parts of Radix Notoginseng, safflower 696.5
Part, 398 parts of dragon's blood, 497.5 parts of frankincense, 497.5 parts of myrrh, 199 parts of camphor, 199 parts of borneol, 14.925 parts of Moschus；
603 parts of radix cyathulae, 804 parts windproof, 804 parts of Rhizoma Et Radix Notopterygii, 703.5 parts of Radix Angelicae Pubescentis, 603 parts of monkshood, 603 parts of teasel root, bone are broken
502.5 parts of benefit, 603 parts of the root of Chinese clematis, 603 parts of rosin, 502.5 parts of the tuber of pinellia, 502.5 parts of caulis sinomenii, 603 parts of anti-Qi, Cortex Eucommiae 160.8
Part, 180.9 parts of radix aconiti agrestis.
The preparation method of above-mentioned dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, step include：
(1) by scorpion, centipede, bovine insects, Chinese blister beetle, vomiting nut, huechys, zaocys dhumnade, leech, Eupolyphoge sinensis, earthworm, Radix Notoginseng,
Safflower, radix cyathulae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, monkshood, teasel root, the rhizome of davallia, the root of Chinese clematis, rosin, the tuber of pinellia, caulis sinomenii, is prevented dragon's blood
Qi, Cortex Eucommiae, radix aconiti agrestis, which are added in sesame oil, to be impregnated 7 days, is then yellowish-brown with the color being boiled by fire to sesame oil, then sesame oil
In the dregs of a decoction filtered out；
(2) then yellow lead is added in the sesame oil after step (1) Chinese medicine slag filters out, small fire is brewed into paste；Then cold
But to 42 DEG C, the Moschus pulverized, frankincense, myrrh, camphor and borneol are put into, be uniformly mixed to get.
Embodiment 3
The dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation of the present embodiment, in terms of parts by weight, raw material includes following component：
2490 parts of sesame oil, 1245 parts of yellow lead, 49.82 parts of scorpion, 49.75 parts of centipede, 37.85 parts of bovine insects, Chinese blister beetle 37.81
Part, 1494 parts of vomiting nut, 37.88 parts of huechys；
697 parts of zaocys dhumnade, 696.5 parts of leech, 696.5 parts of Eupolyphoge sinensis, 597 parts of earthworm, 597 parts of Radix Notoginseng, 697 parts of safflower, blood
Exhaust 400 parts, 497.5 parts of frankincense, 502.5 parts of myrrh, 199 parts of camphor, 199 parts of borneol, 15 parts of Moschus；
597 parts of radix cyathulae, 797 parts windproof, 797 parts of Rhizoma Et Radix Notopterygii, 696.5 parts of Radix Angelicae Pubescentis, 597 parts of monkshood, 597 parts of teasel root, bone are broken
Mend 497.8 parts, 598 parts of the root of Chinese clematis, 597 parts of rosin, 498 parts of the tuber of pinellia, 497.5 parts of caulis sinomenii, 598 parts of anti-Qi, 151 parts of Cortex Eucommiae,
162 parts of radix aconiti agrestis.
The preparation method of above-mentioned dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, step include：
(1) by scorpion, centipede, bovine insects, Chinese blister beetle, vomiting nut, huechys, zaocys dhumnade, leech, Eupolyphoge sinensis, earthworm, Radix Notoginseng,
Safflower, radix cyathulae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, monkshood, teasel root, the rhizome of davallia, the root of Chinese clematis, rosin, the tuber of pinellia, caulis sinomenii, is prevented dragon's blood
Qi, Cortex Eucommiae, radix aconiti agrestis, which are added in sesame oil, to be impregnated 5 days, is then yellowish-brown with the color being boiled by fire to sesame oil, then sesame oil
In the dregs of a decoction filtered out；
(2) then yellow lead is added in the sesame oil after step (1) Chinese medicine slag filters out, small fire is brewed into paste；Then cold
But to 40 DEG C, the Moschus pulverized, frankincense, myrrh, camphor and borneol are put into, be uniformly mixed to get.
Embodiment 4
The dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation of the present embodiment, in terms of parts by weight, raw material includes following component：
2511 parts of sesame oil, 1254 parts of yellow lead, 50.1 parts of scorpion, 50.25 parts of centipede, 38.15 parts of bovine insects, Chinese blister beetle 38.19
Part, 1504 parts of vomiting nut, 38 parts of huechys；
702 parts of zaocys dhumnade, 702 parts of leech, 703.5 parts of Eupolyphoge sinensis, 602 parts of earthworm, 603 parts of Radix Notoginseng, 703.5 parts of safflower, blood
Exhaust 401 parts, 502.5 parts of frankincense, 502 parts of myrrh, 201 parts of camphor, 201 parts of borneol, 19.5 parts of Moschus；
602 parts of radix cyathulae, 804 parts windproof, 804 parts of Rhizoma Et Radix Notopterygii, 703.5 parts of Radix Angelicae Pubescentis, 603 parts of monkshood, 603 parts of teasel root, bone are broken
Mend 501.8 parts, 603 parts of the root of Chinese clematis, 603 parts of rosin, 502 parts of the tuber of pinellia, 502.5 parts of caulis sinomenii, 603 parts of anti-Qi, 158 parts of Cortex Eucommiae,
177 parts of radix aconiti agrestis.
The preparation method of above-mentioned dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, step include：
(1) by scorpion, centipede, bovine insects, Chinese blister beetle, vomiting nut, huechys, zaocys dhumnade, leech, Eupolyphoge sinensis, earthworm, Radix Notoginseng,
Safflower, radix cyathulae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, monkshood, teasel root, the rhizome of davallia, the root of Chinese clematis, rosin, the tuber of pinellia, caulis sinomenii, is prevented dragon's blood
Qi, Cortex Eucommiae, radix aconiti agrestis, which are added in sesame oil, to be impregnated 4 days, is then yellowish-brown with the color being boiled by fire to sesame oil, then sesame oil
In the dregs of a decoction filtered out；
(2) then yellow lead is added in the sesame oil after step (1) Chinese medicine slag filters out, small fire is brewed into paste；Then cold
But to 39 DEG C, the Moschus pulverized, frankincense, myrrh, camphor and borneol are put into, be uniformly mixed to get.
Embodiment 5
The dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation of the present embodiment, in terms of parts by weight, raw material includes following component：
2494.8 parts of sesame oil, 1247 parts of yellow lead, 49.86 parts of scorpion, 49.75 parts of centipede, 37.9 parts of bovine insects, Chinese blister beetle
37.81 parts, 1495 parts of vomiting nut, 37.9 parts of huechys；
701.5 parts of zaocys dhumnade, 701.5 parts of leech, 703.5 parts of Eupolyphoge sinensis, 601 parts of earthworm, 603 parts of Radix Notoginseng, safflower 703.5
Part, 401 parts of dragon's blood, 502.5 parts of frankincense, 501.5 parts of myrrh, 201 parts of camphor, 201 parts of borneol, 19 parts of Moschus；
598 parts of radix cyathulae, 798 parts windproof, 797 parts of Rhizoma Et Radix Notopterygii, 696.5 parts of Radix Angelicae Pubescentis, 597 parts of monkshood, 597 parts of teasel root, bone are broken
498.5 parts of benefit, 598 parts of the root of Chinese clematis, 597 parts of rosin, 498.5 parts of the tuber of pinellia, 497.5 parts of caulis sinomenii, 599 parts of anti-Qi, Cortex Eucommiae 153
Part, 165 parts of radix aconiti agrestis.
The preparation method of above-mentioned dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, step include：
(1) by scorpion, centipede, bovine insects, Chinese blister beetle, vomiting nut, huechys, zaocys dhumnade, leech, Eupolyphoge sinensis, earthworm, Radix Notoginseng,
Safflower, radix cyathulae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, monkshood, teasel root, the rhizome of davallia, the root of Chinese clematis, rosin, the tuber of pinellia, caulis sinomenii, is prevented dragon's blood
Qi, Cortex Eucommiae, radix aconiti agrestis, which are added in sesame oil, to be impregnated 6 days, is then yellowish-brown with the color being boiled by fire to sesame oil, then sesame oil
In the dregs of a decoction filtered out；
(2) then yellow lead is added in the sesame oil after step (1) Chinese medicine slag filters out, small fire is brewed into paste；Then cold
But to 41 DEG C, the Moschus pulverized, frankincense, myrrh, camphor and borneol are put into, be uniformly mixed to get.
Embodiment 6
The dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation of the present embodiment, in terms of parts by weight, raw material includes following component：
2509.5 parts of sesame oil, 1253 parts of yellow lead, 50.05 parts of scorpion, 50.25 parts of centipede, 38.1 parts of bovine insects, Chinese blister beetle
38.19 parts, 1502.5 parts of vomiting nut, 38.1 parts of huechys；
698.5 parts of zaocys dhumnade, 698.5 parts of leech, 696.5 parts of Eupolyphoge sinensis, 598 parts of earthworm, 597 parts of Radix Notoginseng, safflower 697.5
Part, 399 parts of dragon's blood, 497.5 parts of frankincense, 498.5 parts of myrrh, 199 parts of camphor, 199 parts of borneol, 16 parts of Moschus；
601 parts of radix cyathulae, 802 parts windproof, 803 parts of Rhizoma Et Radix Notopterygii, 703.5 parts of Radix Angelicae Pubescentis, 603 parts of monkshood, 603 parts of teasel root, bone are broken
501.5 parts of benefit, 603 parts of the root of Chinese clematis, 603 parts of rosin, 501.5 parts of the tuber of pinellia, 502.5 parts of caulis sinomenii, 602 parts of anti-Qi, Cortex Eucommiae 157
Part, 175 parts of radix aconiti agrestis
The preparation method of above-mentioned dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, step include：
(1) by scorpion, centipede, bovine insects, Chinese blister beetle, vomiting nut, huechys, zaocys dhumnade, leech, Eupolyphoge sinensis, earthworm, Radix Notoginseng,
Safflower, radix cyathulae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, monkshood, teasel root, the rhizome of davallia, the root of Chinese clematis, rosin, the tuber of pinellia, caulis sinomenii, is prevented dragon's blood
Qi, Cortex Eucommiae, radix aconiti agrestis, which are added in sesame oil, to be impregnated 5 days, is then yellowish-brown with the color being boiled by fire to sesame oil, then sesame oil
In the dregs of a decoction filtered out；
(2) then yellow lead is added in the sesame oil after step (1) Chinese medicine slag filters out, small fire is brewed into paste；Then cold
But to 42 DEG C, the Moschus pulverized, frankincense, myrrh, camphor and borneol are put into, be uniformly mixed to get.
Embodiment 7
The dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation of the present embodiment, in terms of parts by weight, raw material includes following component：
2500 parts of sesame oil, 1250 parts of yellow lead, 50 parts of scorpion, 50 parts of centipede, 38 parts of bovine insects, 38 parts of Chinese blister beetle, vomiting nut
1500 parts, 38 parts of huechys；
700 parts of zaocys dhumnade, 700 parts of leech, 700 parts of Eupolyphoge sinensis, 600 parts of earthworm, 600 parts of Radix Notoginseng, 700 parts of safflower, dragon's blood 400
Part, 500 parts of frankincense, 500 parts of myrrh, 200 parts of camphor, 200 parts of borneol, 18 parts of Moschus；
600 parts of radix cyathulae, 800 parts windproof, 800 parts of Rhizoma Et Radix Notopterygii, 700 parts of Radix Angelicae Pubescentis, 600 parts of monkshood, 600 parts of teasel root, the rhizome of davallia
500 parts, 600 parts of the root of Chinese clematis, 600 parts of rosin, 500 parts of the tuber of pinellia, 500 parts of caulis sinomenii, 600 parts of anti-Qi, 155 parts of Cortex Eucommiae, radix aconiti agrestis 170
Part.
The preparation method of above-mentioned dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, step include：
(1) by scorpion, centipede, bovine insects, Chinese blister beetle, vomiting nut, huechys, zaocys dhumnade, leech, Eupolyphoge sinensis, earthworm, Radix Notoginseng,
Safflower, radix cyathulae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, monkshood, teasel root, the rhizome of davallia, the root of Chinese clematis, rosin, the tuber of pinellia, caulis sinomenii, is prevented dragon's blood
Qi, Cortex Eucommiae, radix aconiti agrestis, which are added in sesame oil, to be impregnated 3 days, is then yellowish-brown with the color being boiled by fire to sesame oil, then sesame oil
In the dregs of a decoction filtered out；
(2) then yellow lead is added in the sesame oil after step (1) Chinese medicine slag filters out, small fire is brewed into paste；Then cold
But to 40 DEG C, the Moschus pulverized, frankincense, myrrh, camphor and borneol are put into, be uniformly mixed to get.
Comparative example 1
The dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation of the present embodiment, in terms of parts by weight, raw material includes following component：
2500 parts of sesame oil, 1250 parts of yellow lead, 50 parts of scorpion, 50 parts of centipede, 200 parts of vomiting nut；
700 parts of zaocys dhumnade, 700 parts of leech, 700 parts of Eupolyphoge sinensis, 600 parts of earthworm, 600 parts of Radix Notoginseng, 700 parts of safflower, dragon's blood 400
Part, 500 parts of frankincense, 500 parts of myrrh, 200 parts of camphor, 200 parts of borneol, 18 parts of Moschus；
600 parts of radix cyathulae, 800 parts windproof, 800 parts of Rhizoma Et Radix Notopterygii, 700 parts of Radix Angelicae Pubescentis, 600 parts of monkshood, 600 parts of teasel root, the rhizome of davallia
500 parts, 600 parts of the root of Chinese clematis, 600 parts of rosin, 500 parts of the tuber of pinellia, 500 parts of caulis sinomenii, 600 parts of anti-Qi, 155 parts of Cortex Eucommiae, radix aconiti agrestis 170
Part.
The preparation method of above-mentioned dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, step include：
(1) by scorpion, centipede, vomiting nut, zaocys dhumnade, leech, Eupolyphoge sinensis, earthworm, Radix Notoginseng, safflower, dragon's blood, radix cyathulae, anti-
Wind, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, monkshood, teasel root, the rhizome of davallia, the root of Chinese clematis, rosin, the tuber of pinellia, caulis sinomenii, anti-Qi, Cortex Eucommiae, radix aconiti agrestis are added to fiber crops
It is impregnated 3 days in oil, is then yellowish-brown with the color being boiled by fire to sesame oil, then the dregs of a decoction in sesame oil are filtered out；
(2) then yellow lead is added in the sesame oil after step (1) Chinese medicine slag filters out, small fire is brewed into paste；Then cold
But to 40 DEG C, the Moschus pulverized, frankincense, myrrh, camphor and borneol are put into, be uniformly mixed to get.
Comparative example 2
The dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation of the present embodiment, in terms of parts by weight, raw material includes following component：
2500 parts of sesame oil, 1250 parts of yellow lead, 50 parts of scorpion, 50 parts of centipede, 52 parts of bovine insects, 5 parts of Chinese blister beetle, vomiting nut 2000
Part, 65 parts of huechys；
700 parts of zaocys dhumnade, 700 parts of leech, 700 parts of Eupolyphoge sinensis, 600 parts of earthworm, 600 parts of Radix Notoginseng, 700 parts of safflower, dragon's blood 400
Part, 500 parts of frankincense, 500 parts of myrrh, 200 parts of camphor, 200 parts of borneol, 18 parts of Moschus；
600 parts of radix cyathulae, 800 parts windproof, 800 parts of Rhizoma Et Radix Notopterygii, 700 parts of Radix Angelicae Pubescentis, 600 parts of monkshood, 600 parts of teasel root, the rhizome of davallia
500 parts, 600 parts of the root of Chinese clematis, 600 parts of rosin, 500 parts of the tuber of pinellia, 500 parts of caulis sinomenii, 600 parts of anti-Qi, 155 parts of Cortex Eucommiae, radix aconiti agrestis 170
Part.
The preparation method of above-mentioned dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, step include：
(1) by scorpion, centipede, bovine insects, Chinese blister beetle, vomiting nut, huechys, zaocys dhumnade, leech, Eupolyphoge sinensis, earthworm, Radix Notoginseng,
Safflower, radix cyathulae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, monkshood, teasel root, the rhizome of davallia, the root of Chinese clematis, rosin, the tuber of pinellia, caulis sinomenii, is prevented dragon's blood
Qi, Cortex Eucommiae, radix aconiti agrestis, which are added in sesame oil, to be impregnated 3 days, is then yellowish-brown with the color being boiled by fire to sesame oil, then sesame oil
In the dregs of a decoction filtered out；
(2) then yellow lead is added in the sesame oil after step (1) Chinese medicine slag filters out, small fire is brewed into paste；Then cold
But to 40 DEG C, the Moschus pulverized, frankincense, myrrh, camphor and borneol are put into, be uniformly mixed to get.
Comparative example 3
The dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation of the present embodiment, in terms of parts by weight, raw material includes following component：
2500 parts of sesame oil, 1250 parts of yellow lead, 50 parts of scorpion, 50 parts of centipede；
700 parts of zaocys dhumnade, 700 parts of leech, 700 parts of Eupolyphoge sinensis, 600 parts of earthworm, 600 parts of Radix Notoginseng, 700 parts of safflower, dragon's blood 400
Part, 500 parts of frankincense, 500 parts of myrrh, 200 parts of camphor, 200 parts of borneol, 18 parts of Moschus；
600 parts of radix cyathulae, 800 parts windproof, 800 parts of Rhizoma Et Radix Notopterygii, 700 parts of Radix Angelicae Pubescentis, 600 parts of monkshood, 600 parts of teasel root, the rhizome of davallia
500 parts, 600 parts of the root of Chinese clematis, 600 parts of rosin, 500 parts of the tuber of pinellia, 500 parts of caulis sinomenii, 600 parts of anti-Qi, 155 parts of Cortex Eucommiae, radix aconiti agrestis 170
Part.
The preparation method of above-mentioned dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, step include：
(1) by scorpion, centipede, zaocys dhumnade, leech, Eupolyphoge sinensis, earthworm, Radix Notoginseng, safflower, dragon's blood, radix cyathulae, windproof, Rhizoma Et Radix Notopterygii,
Radix Angelicae Pubescentis, monkshood, teasel root, the rhizome of davallia, the root of Chinese clematis, rosin, the tuber of pinellia, caulis sinomenii, anti-Qi, Cortex Eucommiae, radix aconiti agrestis are added in sesame oil and impregnate 3
It, is then yellowish-brown with the color being boiled by fire to sesame oil, then the dregs of a decoction in sesame oil is filtered out；
(2) then yellow lead is added in the sesame oil after step (1) Chinese medicine slag filters out, small fire is brewed into paste；Then cold
But to 40 DEG C, the Moschus pulverized, frankincense, myrrh, camphor and borneol are put into, be uniformly mixed to get.
Embodiment 8
The animal toxicology experiment of dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation in embodiment 1-7 and comparative example 1-3：
1, acute toxicity test
The Chinese medicine preparation prepared with embodiment 1-7 (hereinafter referred to as experimental group) and comparative example 1-3 (hereinafter referred to as contrast groups)
80g crude drug amounts, accumulation in interior successive administration 3 times for 24 hours, per minor tick 4h, are administered using gastric infusion mode every time for experiment
Drug total amount reaches 240g crude drugs/kg, is equivalent to 80 times of people's quantity.
Experimental group：After administration in 7d, mouse activity, drains normal, well-grown at feed, and hair color is bright, and be averaged body
Weight increases with the extension of experimental period.Every mouse of post mortem at 8d, visually observe the heart, liver, spleen, lung, kidney, brain,
Thymus gland, stomach, intestines etc. do not find color and paramophia, fail to measure median lethal dose (LD50).The result shows that：System of the present invention
Standby Chinese drugs agentia is without acute toxic reaction.
Contrast groups：After administration in 7d, mouse activity, feed, excretion are abnormal, and growth is general, dull, are averaged
Weight does not occur increase with the extension of experimental period.Every mouse of post mortem at 8d, visually observe the heart, liver, spleen,
Lung, kidney, brain, thymus gland, stomach, intestines etc. find color and paramophia, can measure median lethal dose (LD50).The result shows that：Comparison
Chinese drugs agentia prepared by example 1, comparative example 2 and comparative example 3 all has acute toxic reaction, LD50Value respectively 234.21 ±
15.78g/kg、12.49±3.91g/kg、615.53±48.01g/kg。
2, long term toxicity test
It is experiment with Chinese medicine preparation prepared by experimental group and contrast groups, using gastric infusion mode, wherein experimental group is divided into
Low dosage, middle dosage, three groups of high dose, the drug dose of each group is respectively 30,60,120g crude drugs/kg/d, be equivalent to clinical agent
10,20,40 times of amount.
Experimental group：After gastric infusion 12 weeks, to the general status of animal, hematological indices, blood parameters without bright
Aobvious influence, Systematic anatomy, organ coefficient and histopathological examination also no abnormal pathological change.It is discontinued 2 weeks and also has no
It substantially change.The result shows that：Chinese drugs agentia prepared by experimental group does not find overt toxicity reaction and prolongs in long term toxicity test
Slow toxic reaction.As it can be seen that Chinese drugs agentia non-toxic reaction prepared by the present invention, long-term administration are safe and reliable.
Contrast groups：After gastric infusion 12 weeks, have to the general status of animal, hematological indices, blood parameters bright
Aobvious influence, Systematic anatomy, organ coefficient and histopathological examination note abnormalities pathological change.Being discontinued 2 weeks, it is bright also to occur
It is aobvious to change.The result shows that：Chinese drugs agentia prepared by comparative example 1, comparative example 2 and comparative example 3 is found in long term toxicity test
Overt toxicity reacts and delayed toxicity reaction.As it can be seen that Chinese drugs agentia prepared by comparative example 1, comparative example 2 and comparative example 3 is toxic
Property reaction, long-term administration safety is low.
Embodiment 9
The Chinese medicine preparation prepared with embodiment 1-7 (hereinafter referred to as experimental group) and comparative example 1-3 (hereinafter referred to as contrast groups)
For experiment；
The pharmacodynamics test of animal model：
By 120 weight 18g-22g, the Kun Ming mice of half male and half female is divided into 12 groups, every group 10, that is, tests
Group, contrast groups, aspirin group and physiological saline group, it is (every that experimental group feeds the Chinese medicine preparation prepared with contrast groups to mouse respectively
Kg mouse feed 20ml liquids), aspirin group feeds aspirin (feeding 0.29g aspirin per kg mouse), physiology salt to mouse
Water group feeds physiological saline (feeding 20ml physiology liquid medicine per kg mouse) to mouse, and successive administration 1 week, 3min exists after last 1 administration
Dimethylbenzene 0.lml is applied inside and outside the auris dextra of mouse, cervical dislocation puts to death small white mouse after 15 minutes, with card punch in mouse or so ear
Same area is punched and is weighed respectively.
As shown in table 1, experimental group and aspirin group paraxylene induced mice auricle edema have apparent inhibiting effect,
Relatively there is notable difference with contrast groups and physiological saline.
Table 1
| Group | Number of cases | Auricle edema degree (mg) |
| Embodiment 1 | 10 | 1.94±0.56 |
| Embodiment 2 | 10 | 2.08±0.32 |
| Embodiment 3 | 10 | 1.87±0.22 |
| Embodiment 4 | 10 | 1.65±0.37 |
| Embodiment 5 | 10 | 1.44±0.35 |
| Embodiment 6 | 10 | 1.41±0.45 |
| Embodiment 7 | 10 | 1.32±0.25 |
| Comparative example 1 | 10 | 2.23±0.58 |
| Comparative example 2 | 10 | 2.55±0.37 |
| Comparative example 3 | 10 | 3.02±0.44 |
| Aspirin group | 10 | 1.87±0.51 |
| Physiological saline group | 10 | 3.68±0.83 |
Embodiment 10
It is experiment with Chinese drugs agentia prepared by embodiment 7, Chinese drugs agentia is uniformly applied on sterile-cloth, the Chinese medicine
Dosing is 15-35g (adjustment that dosage is carried out according to actual conditions), is then affixed on affected part, a patch 7 days.
(1) clinical application of rheumatic arthritis
Clinical statistics basic document：Reference《Chinese medical disease Standardization of diagnosis and curative effect》It (cures the desease in State Administration of Traditional Chinese Medicine
Demonstrate,prove the Nanjing Standardization of diagnosis and curative effect:Publishing house of Nanjing University, 1994), in June, 2017-August is chosen in Hefei City's hospital admission
Patient 80, in hospital or outpatient, between basic age 25-50 Sui, average age is 38 years old, the wherein course of disease most elder 3
Year, most short person's March；Rheumatic arthritis is turned out to be through CT and X-ray.Random to be divided to two groups, control group and treatment group, two groups in year
Age, gender, coincident with severity degree of condition are comparable without too big difference.
Therapeutic modality：Control group is treated using Western medicine Nuprin Tablets, takes Western medicine brufen daily, two times a day, once
200mg；Treatment group is treated using Chinese drugs agentia prepared by embodiment 7, and the Chinese drugs agentia dosage is 25g, a patch 7
It.Every 14 days as a treatment course observe curative effect after treating three courses for the treatment of.
Clinical development standard：
Effectively：Pain numbness is substantially reduced after treatment.
In vain：Symptom is without significant change after treatment.
Therapeutic effect：
Therapeutic effect is shown in Table 2, the results show that the clinical therapeutic efficacy of Chinese drugs agentia of the present invention is significantly better than existing Western medicine
Nuprin Tablets are treated, and the present invention is pure Chinese medicinal preparation, has no toxic side effect, there is good potential applicability in clinical practice, and treatment group 36
Example treats effective patient and is discontinued in half a year without recurrence.
Table 2
| Group | Age | Case load | Effective number of cases | Invalid number of cases | Total effective rate |
| Treatment group | 25-50 | 40 | 36 | 4 | 90% |
| Control group | 25-50 | 40 | 15 | 25 | 37.5% |
(2) clinical application of cervical spondylosis
Clinical statistics basic document：Reference《Chinese medical disease Standardization of diagnosis and curative effect》It (cures the desease in State Administration of Traditional Chinese Medicine
Demonstrate,prove the Nanjing Standardization of diagnosis and curative effect:Publishing house of Nanjing University, 1994), in June, 2017-August is chosen in Hefei City's hospital admission
Patient 100, in hospital or outpatient, between basic age 25-50 Sui, average age is 41 years old, the wherein course of disease most elder 6
Year, most short person's March；Cervical Disk Herniation is turned out to be through CT and X-ray.Random to be divided to two groups, control group and treatment group, two groups in year
Age, gender, coincident with severity degree of condition are comparable without too big difference.
Therapeutic modality：Control group is using massage and the treatment of Western medicine Nuprin Tablets, and massage 30min daily, while auxiliary is taken
Western medicine brufen, two times a day, a 200mg；Treatment group is treated using Chinese drugs agentia prepared by embodiment 7, in described
Medicine dosing is 25g, a patch 7 days.Every 14 days as a treatment course observe curative effect after treating three courses for the treatment of.
Clinical development standard：
Effectively：Pain numbness is substantially reduced after treatment.
In vain：Symptom is without significant change after treatment.
Therapeutic effect：
Therapeutic effect is shown in Table 3, the results show that the clinical therapeutic efficacy of Chinese drugs agentia of the present invention is significantly better than existing massage
And the treatment of Western medicine Nuprin Tablets, and the present invention is pure Chinese medicinal preparation, has no toxic side effect, has good potential applicability in clinical practice, and control
43 effective patients for the treatment of of treatment group are discontinued in half a year without recurrence.
Table 3
| Group | Age | Case load | Effective number of cases | Invalid number of cases | Total effective rate |
| Treatment group | 25-50 | 50 | 43 | 7 | 86% |
| Control group | 25-50 | 50 | 32 | 18 | 64% |
(3) clinical application of scapulohumeral periarthritis
Clinical statistics basic document：Reference《Chinese medical disease Standardization of diagnosis and curative effect》It (cures the desease in State Administration of Traditional Chinese Medicine
Demonstrate,prove the Nanjing Standardization of diagnosis and curative effect:Publishing house of Nanjing University, 1994), June in January, 2017-is chosen in Hefei City's hospital admission
Patient 80, in hospital or outpatient, between basic age 25-50 Sui, average age is 46 years old, the wherein course of disease most elder 5
Year, most short person's March；Scapulohumeral periarthritis is turned out to be through CT and X-ray.Random to be divided to two groups, control group and treatment group, two groups in age, property
Not, coincident with severity degree of condition is comparable without too big difference.
Therapeutic modality：Control group is using massage and the treatment of Western medicine Nuprin Tablets, and massage 30min daily, while auxiliary is taken
Western medicine brufen, two times a day, a 200mg；Treatment group is treated using Chinese drugs agentia prepared by embodiment 7, in described
Medicine dosing is 25g, a patch 7 days.Every 14 days as a treatment course observe curative effect after treating three courses for the treatment of.
Clinical development standard：
Effectively：Pain numbness is substantially reduced after treatment.
In vain：Symptom is without significant change after treatment.
Therapeutic effect：
Therapeutic effect is shown in Table 4, the results show that the clinical therapeutic efficacy of Chinese drugs agentia of the present invention is significantly better than existing massage
And the treatment of Western medicine Nuprin Tablets, and the present invention is pure Chinese medicinal preparation, has no toxic side effect, has good potential applicability in clinical practice, and control
33 effective patients for the treatment of of treatment group are discontinued in half a year without recurrence.
Table 4
| Group | Age | Case load | Effective number of cases | Invalid number of cases | Total effective rate |
| Treatment group | 25-50 | 40 | 33 | 7 | 82.5% |
| Control group | 25-50 | 40 | 22 | 18 | 55% |
(4) clinical application of lumbar muscle strain
Clinical statistics basic document：Reference《Chinese medical disease Standardization of diagnosis and curative effect》It (cures the desease in State Administration of Traditional Chinese Medicine
Demonstrate,prove the Nanjing Standardization of diagnosis and curative effect:Publishing house of Nanjing University, 1994), choose in April, -2017 in December, 2016 and cured in Hefei City
The medical patient 100 of institute, in hospital or outpatient, between basic age 25-50 Sui, average age is 43 years old, the wherein course of disease
Most elder 8 years, most short person's March；Lumbar muscle strain is turned out to be through CT and X-ray.It is random to be divided to two groups, control group and treatment group, two groups
In age, gender, coincident with severity degree of condition without too big difference, it is comparable.
Therapeutic modality：Control group is using massage and the treatment of Western medicine Nuprin Tablets, and massage 30min daily, while auxiliary is taken
Western medicine brufen, two times a day, a 200mg；Treatment group is treated using Chinese drugs agentia prepared by embodiment 7, in described
Medicine dosing is 25g, a patch 7 days.Every 14 days as a treatment course observe curative effect after treating three courses for the treatment of.
Clinical development standard：
Effectively：Pain numbness is substantially reduced after treatment.
In vain：Symptom is without significant change after treatment.
Therapeutic effect：
Therapeutic effect is shown in Table 5, the results show that the clinical therapeutic efficacy of Chinese drugs agentia of the present invention is significantly better than existing massage
And the treatment of Western medicine Nuprin Tablets, and the present invention is pure Chinese medicinal preparation, has no toxic side effect, has good potential applicability in clinical practice, and control
42 effective patients for the treatment of of treatment group are discontinued in half a year without recurrence.
Table 5
| Group | Age | Case load | Effective number of cases | Invalid number of cases | Total effective rate |
| Treatment group | 25-50 | 50 | 42 | 8 | 84% |
| Control group | 25-50 | 50 | 33 | 17 | 66% |
(5) clinical application of osteoproliferation
Clinical statistics basic document：Reference《Chinese medical disease Standardization of diagnosis and curative effect》It (cures the desease in State Administration of Traditional Chinese Medicine
Demonstrate,prove the Nanjing Standardization of diagnosis and curative effect:Publishing house of Nanjing University, 1994), choose in January, -2017 in June, 2016 and cured in Hefei City
The medical patient 100 of institute, in hospital or outpatient, between basic age 25-50 Sui, average age is 45 years old, the wherein course of disease
Longest 4 years, most short person's March；Osteoproliferation is turned out to be through CT and X-ray.It is random to be divided to two groups, control group and treatment group, two groups
Age, gender, coincident with severity degree of condition are comparable without too big difference.
Therapeutic modality：Control group is using massage and the treatment of Western medicine Nuprin Tablets, and massage 30min daily, while auxiliary is taken
Western medicine brufen, two times a day, a 200mg；Treatment group is treated using Chinese drugs agentia prepared by embodiment 7, in described
Medicine dosing is 25g, a patch 7 days.Every 14 days as a treatment course observe curative effect after treating three courses for the treatment of.
Clinical development standard：
Effectively：Pain numbness is substantially reduced after treatment.
In vain：Symptom is without significant change after treatment.
Therapeutic effect：
Therapeutic effect is shown in Table 6, the results show that the clinical therapeutic efficacy of Chinese drugs agentia of the present invention is significantly better than existing massage
And the treatment of Western medicine Nuprin Tablets, and the present invention is pure Chinese medicinal preparation, has no toxic side effect, has good potential applicability in clinical practice, and control
40 effective patients for the treatment of of treatment group are discontinued in half a year without recurrence.
Table 6
| Group | Age | Case load | Effective number of cases | Invalid number of cases | Total effective rate |
| Treatment group | 25-50 | 50 | 40 | 10 | 80% |
| Control group | 25-50 | 50 | 25 | 25 | 50% |
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiment being appreciated that.
Claims (7)
1. a kind of dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, it is characterised in that：In terms of parts by weight, raw material includes following component：
2487.5 parts -2512.5 parts of sesame oil, 1243.75 parts -1256.25 parts of yellow lead, 49.75 parts -50.25 parts of scorpion, centipede
49.75 parts -50.25 parts, 37.81 parts -38.19 parts of bovine insects, 37.81 parts -38.19 parts of Chinese blister beetle, 1492.5 parts of vomiting nut -
1507.5 parts, 37.81 parts -38.19 parts of huechys；
696.5 parts -703.5 parts of zaocys dhumnade, 696.5 parts -703.5 parts of leech, 696.5 parts -703.5 parts of Eupolyphoge sinensis, 597 parts of earthworm -
603 parts, 597 parts -603 parts of Radix Notoginseng, 696.5 parts -703.5 parts of safflower, 398 parts -402 parts of dragon's blood, 497.5 part -502.5 of frankincense
Part, 497.5 parts -502.5 parts of myrrh, 199 parts -201 parts of camphor, 199 parts -201 parts of borneol, 14.925 parts -20.1 parts of Moschus；
597 parts -603 parts of radix cyathulae, 796 parts -804 parts windproof, 796 parts -804 parts of Rhizoma Et Radix Notopterygii, 696.5 parts -703.5 parts of Radix Angelicae Pubescentis, river
597 parts -603 parts of crow, 597 parts -603 parts of teasel root, 497.5 parts -502.5 parts of the rhizome of davallia, 597 parts -603 parts of the root of Chinese clematis, rosin 597
- 603 parts of part, 497.5 parts -502.5 parts of the tuber of pinellia, 497.5 parts -502.5 parts of caulis sinomenii, 597 parts -603 parts of anti-Qi, Cortex Eucommiae 149.25
Part -160.8 parts, 159.2 parts -180.9 parts of radix aconiti agrestis.
2. a kind of dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation according to claim 1, it is characterised in that：The dispelling wind-evil and wetness-evil is lived
Blood Chinese medicine preparation, in terms of parts by weight, raw material includes following component：
2494.8 parts -2509.5 parts of sesame oil, 1247 parts -1253 parts of yellow lead, 49.86 parts -50.05 parts of scorpion, 49.75 parts of centipede -
50.25 parts, 37.9 parts -38.1 parts of bovine insects, 37.81 parts -38.19 parts of Chinese blister beetle, 1495 parts -1502.5 parts of vomiting nut, huechys
37.9 parts -38.1 parts；
698.5 parts -701.5 parts of zaocys dhumnade, 698.5 parts -701.5 parts of leech, 696.5 parts -703.5 parts of Eupolyphoge sinensis, 598 parts of earthworm -
601 parts, 597 parts -603 parts of Radix Notoginseng, 697.5 parts -703.5 parts of safflower, 399 parts -401 parts of dragon's blood, 497.5 part -502.5 of frankincense
Part, 498.5 parts -501.5 parts of myrrh, 199 parts -201 parts of camphor, 199 parts -201 parts of borneol, 16 parts -19 parts of Moschus；
598 parts -601 parts of radix cyathulae, 798 parts -802 parts windproof, 797 parts -803 parts of Rhizoma Et Radix Notopterygii, 696.5 parts -703.5 parts of Radix Angelicae Pubescentis, river
597 parts -603 parts of crow, 597 parts -603 parts of teasel root, 498.5 parts -501.5 parts of the rhizome of davallia, 598 parts -603 parts of the root of Chinese clematis, rosin 597
- 603 parts of part, 498.5 parts -501.5 parts of the tuber of pinellia, 497.5 parts -502.5 parts of caulis sinomenii, 599 parts -602 parts of anti-Qi, 153 parts of Cortex Eucommiae -
157 parts, 165 parts -175 parts of radix aconiti agrestis.
3. a kind of dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation according to claim 1, it is characterised in that：The dispelling wind-evil and wetness-evil is lived
Blood Chinese medicine preparation, in terms of parts by weight, raw material includes following component：
2500 parts of sesame oil, 1250 parts of yellow lead, 50 parts of scorpion, 50 parts of centipede, 38 parts of bovine insects, 38 parts of Chinese blister beetle, 1500 parts of vomiting nut,
38 parts of huechys；
700 parts of zaocys dhumnade, 700 parts of leech, 700 parts of Eupolyphoge sinensis, 600 parts of earthworm, 600 parts of Radix Notoginseng, 700 parts of safflower, 400 parts of dragon's blood,
500 parts of frankincense, 500 parts of myrrh, 200 parts of camphor, 200 parts of borneol, 18 parts of Moschus；
600 parts of radix cyathulae, 800 parts windproof, 800 parts of Rhizoma Et Radix Notopterygii, 700 parts of Radix Angelicae Pubescentis, 600 parts of monkshood, 600 parts of teasel root, the rhizome of davallia 500
Part, 600 parts of the root of Chinese clematis, 600 parts of rosin, 500 parts of the tuber of pinellia, 500 parts of caulis sinomenii, 600 parts of anti-Qi, 155 parts of Cortex Eucommiae, 170 parts of radix aconiti agrestis.
4. a kind of dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation according to claim 1-3 any one, it is characterised in that：Described
The dosage form of Chinese medicine preparation is pharmaceutically acceptable dosage form.
5. a kind of dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation according to claim 4, it is characterised in that：The Chinese medicine preparation
Dosage form is powder, patch or ointment.
6. a kind of preparation method of dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation, step include：
(1) by scorpion, centipede, bovine insects, Chinese blister beetle, vomiting nut, huechys, zaocys dhumnade, leech, Eupolyphoge sinensis, earthworm, Radix Notoginseng, safflower,
Dragon's blood, radix cyathulae, windproof, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, monkshood, teasel root, the rhizome of davallia, the root of Chinese clematis, rosin, the tuber of pinellia, caulis sinomenii, anti-Qi, Du
Secondary, radix aconiti agrestis, which is added in sesame oil, to be impregnated -7 days 3 days, is then yellowish-brown with the color being boiled by fire to sesame oil, then sesame oil
In the dregs of a decoction filtered out；
(2) then yellow lead is added in the sesame oil after step (1) Chinese medicine slag filters out, small fire is brewed into paste；It is then cooled to
38 DEG C -42 DEG C, be put into the Moschus pulverized, frankincense, myrrh, camphor and borneol, be uniformly mixed to get.
7. a kind of preparation method of dispelling wind-evil and wetness-evil blood-activating Chinese medicine preparation according to claim 6, it is characterised in that：Step
(2) 40 DEG C are cooled in.
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