CN104857218B - A kind of nursing medicine treating prolapse of lumbar intervertebral disc - Google Patents

A kind of nursing medicine treating prolapse of lumbar intervertebral disc Download PDF

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CN104857218B
CN104857218B CN201510342360.4A CN201510342360A CN104857218B CN 104857218 B CN104857218 B CN 104857218B CN 201510342360 A CN201510342360 A CN 201510342360A CN 104857218 B CN104857218 B CN 104857218B
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intervertebral disc
lumbar intervertebral
prolapse
medicine
radix
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CN104857218A (en
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倪萍
孟凡军
任井斌
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Henan Yuhai Pharmaceutical Technology Co Ltd
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Abstract

The invention belongs to pharmaceutical technology field, be specifically related to a kind of nursing medicine treating prolapse of lumbar intervertebral disc.The components such as described nursing medicine is by Rhizoma Et Radix Notopterygii, Radix Flemingiae Philippinensis, Herba Taxilli, Radix Clematidis, Herba Lycopodii, Semen Persicae, Flos Carthami, Fructus Toosendan, Rhizoma Pinelliae composition.Nursing medicine of the present invention treatment prolapse of lumbar intervertebral disc in terms of, determined curative effect, there is dispelling cold by warming the meridian, expelling wind and removing dampness, activating collaterals and eliminating stagnation, strong muscles and bones, blood circulation promoting and blood stasis dispelling, the special effect of promoting the circulation of QI to relieve pain, can as nursing prolapse of lumbar intervertebral disc active drug.

Description

A kind of nursing medicine treating prolapse of lumbar intervertebral disc
Technical field
The invention belongs to pharmaceutical technology field, be specifically related to a kind of nursing medicine treating prolapse of lumbar intervertebral disc.
Background technology
Prolapse of lumbar intervertebral disc is the most common a kind of osteopathia, belongs to the traditional Chinese medical science " lumbago " " arthromyodynia " category.Etiology and pathogenesis is Deficiency of the liver and kindey, muscles and bones are not good for, are frustrated by torsion again, or sense wind-cold damp pathogen, obstruction of meridians and collaterals, qi depression to blood stasis.Tcm syndrome classification has Syndrome of blood stasis, cold-damp syndrome, damp-heat syndrome, caused by liver and kidney deficiency.Pathological have unilateral intervertebral disk hernia, bilateral prolapse of intervertebral disc, in Centre type prolapse of intervertebral disc, upper mo(u)ld bottom half prolapse of intervertebral disc.Utilize modern scientific research method, Chinese medicine prolapse of lumbar intervertebral disc Science and reliability be significantly improved, it is possible to substantially alleviating the misery of patient, and toxic and side effects is little, effective percentage is high. Therefore profound under the instruction of Chinese Medicine theory nursing Chinese medicine preparation exploring treatment prolapse of lumbar intervertebral disc is also applied to clinical expansion Necessary.
Summary of the invention
The invention provides a kind of nursing medicine treating prolapse of lumbar intervertebral disc, its safety is high, effective, can be as protecting The ideal medicament of reason prolapse of lumbar intervertebral disc.Medicament composing prescription of the present invention is rigorous, compatibility science, and preparation is convenient, and patient compliance is good, Without any side effects, clinic promotion and application.
For reaching above-mentioned purpose, the technical scheme that the present invention provides is the nursing medicine of described treatment prolapse of lumbar intervertebral disc, its The composition and ratio of crude drug is: Rhizoma Et Radix Notopterygii 10-20g, Radix Flemingiae Philippinensis 5-15g, Herba Taxilli 5-10g, Radix Clematidis 8-16g, Herba Lycopodii 5-15g, Semen Persicae 5-15g, Flos Carthami 3-8g, Fructus Toosendan 5-12g, Rhizoma Pinelliae 1-10g.
Optimal technical scheme of the present invention is, nursing medicine of the present invention is prepared by the material medicine of following weight proportion: Rhizoma Et Radix Notopterygii 14-16g, Radix Flemingiae Philippinensis 8-12g, Herba Taxilli 7-8g, Radix Clematidis 11-12g, Herba Lycopodii 8-10g, Semen Persicae 8-12g are red Flower 5-7g, Fructus Toosendan 7-8g, Rhizoma Pinelliae 4-6g.
Most preferred technique scheme of the present invention is, nursing medicine of the present invention is prepared by the material medicine of following weight proportion: Rhizoma Et Radix Notopterygii 15g, Radix Flemingiae Philippinensis 10g, Herba Taxilli 8g, Radix Clematidis 12g, Herba Lycopodii 9g, Semen Persicae 10g, Flos Carthami 6g, Fructus Toosendan 8g, Rhizoma Pinelliae 5g.
Present invention also offers the preparation method of described nursing medicine, specifically comprise: according to aforesaid weight weigh above in Medicine each component, decocts 2-3 time after soaking 2-3h, adds the water of medicine gross weight 6-8 times every time, decoct 2-3 after mix homogeneously Hour, merge decoction liquor, filter;When filtrate concentrates 75 DEG C, relative density is the extractum of 1.11-1.21, makes through normal process steps Clinically-acceptable dosage form.
Nursing medicine of the present invention can be prepared as external preparation.Preferably it is prepared as lotion, liniment or ointment. More preferably it is prepared as ointment.
The present invention is also claimed above-mentioned nursing medicine purposes in the medicine of preparation treatment prolapse of lumbar intervertebral disc.Particularly Described nursing pharmaceutical preparation purposes in the medicine of preparation treatment cold-dampness type prolapse of lumbar intervertebral disc.The invention provides institute State the clinical observation in treatment prolapse of lumbar intervertebral disc of the nursing medicine
1), case-data: select hospital outpatient cold-dampness type prolapse of lumbar intervertebral disc patient 116 example, be unilateral intervertebral disk hernia, Divide and rule at random treatment group and matched group.Treatment group 58 example, male 40 examples, female 18 example;Age between 21-60 year, average year 49.2 ± 3.9 years old age;The course of disease at 10 days-36 months, average course of disease 20.3 ± 3.5 months;Matched group 58 example, male 42 examples, Female 16 example;Age between 23-59 year, 48.1 ± 3.5 years old mean age, the course of disease at 5 days-35 months, average course of disease 19.9 ± 3.2 months.The data of two groups of patients includes that sex, age, the course of disease, severity extent aspect etc. compare, P > 0.05, There was no significant difference, there is comparability.
2), diagnosis and exclusion standard:
The diagnosis of all patients is all according to diagnosis about cold-dampness type prolapse of lumbar intervertebral disc in " disease of tcm curative effect is for standard " Standard:
(1) there are waist wound, chronic strain or by cold-damp history.Major part patient has chronic back pain history at premorbid.
(2) person between twenty and fifty are often betided.
(3) lumbago is radiated to buttocks and lower limb, and when abdominal pressure increases (such as cough, sneeze), pain increases the weight of.
(4) scoliosis, waist physiology radians disappears, and has tenderness, and radiate to lower limb, waist limitation of activity by diseased region vertebra..
(5) the lower limb innervation district that gets involved feels allergy or blunt, and course of disease elder may occur in which amyotrophy.Leg raising straight or Strengthening the test positive, knee joint, Achilles tendon reflex weaken or disappear, and big toe dorsiflexion power weakens.
(6) x-ray takes the photograph sheet inspection: scoliosis, waist physiology lordosis disappears, and pathological interspinal dish may narrow, and neighboring edge has Osteophytosis.CT examination can show position and the degree of intervertebral disk hernia.
TCM syndrome is cold-damp syndrome: waist-leg cold type of pain weighs, and changes one's position unfavorable, and the pain that reposes does not subtracts, and catches cold and wet weather increases the weight of, limbs Send out cool.Pale tongue, Tai Bai or greasy, deep and tense pulse or slow.Pathological:
(1) unilateral intervertebral disk hernia: low back pain companion side lower limb radiating pain, scoliosis, waist physiology lordosis reduces or disappears, The other pressure of pathological interspinal dish Ipsilateral vertebra is gushed, and can radiate along sciatic nerve to lower limb, and straight-leg raising test is positive.CT checks: intervertebral Dish is prominent to canalis spinalis side.
(2) bilateral prolapse of intervertebral disc: low back pain, accompanies bilateral lower limb radiating pain, and waist physiology lordosis reduces or disappears, pathological changes vertebra All having tenderness by the vertebra of intercalated disc both sides, can radiate to lower limb along sciatic nerve, double lower limb straight-leg raising tests are positive.CT checks: Highlight about intervertebral disc meat, and visible free block.
(3) central type prolapse of intervertebral disc: in addition to symptom lumbago and skelalgia occur, it may also occur that perineal position numbness and fecal and urinary functions The cauda equina nerve stress disorders such as obstacle.CT examination: intervertebral disc is prominent to direction, center.
(4) upper mo(u)ld bottom half prolapse of intervertebral disc: major part patient only has lumbago symptom, Schmori seen from X-ray examination pathological interspinal dish Tuberosity.
Exclusion standard: get rid of the patient of gravidic women, rheumarthrosis, three-hypers, osteoporosis.
3), Therapeutic Method:
Matched group: during the traction of row basin, the weight of traction is about the half of sufferer body weight, and carrying out seance needs 25min, Adhere to every day 2~3 times.During treatment, doctor to inquire whether patient can bear the pain that traction brings in time, close Cut the change paying close attention to the state of an illness, notes patient during treating produced reaction the most normally, stabilizing the emotions, firm defeat disease Sick confidence.
Treatment group: on the basis of matched group, uses the ointment prepared by the embodiment of the present invention 1, applies affected part the most gently, Every day 3-4 time, 10 days is 1 course for the treatment of.
Two groups all take statistics clinical efficacy result after 1 course for the treatment of.
4), the standard of curative effect evaluation: the efficacy assessment standard according to relevant in " Chinese medical disease Standardization of diagnosis and curative effect ":
(1) cure: lumbago and skelalgia disappears, leg raising straight more than 70 °, can extensive recovery operation;
(2) taking a turn for the better: lumbago and skelalgia alleviates, waist movable function improves;
(3) invalid: symptom, sign are without improving.
Total effective rate is cure rate and obvious effective rate sum.
5), therapeutic effect:
116 example patients, without coming off, exiting case, all complete clinical observation.
After terminating 1 course for the treatment of, therapeutic effect to two groups of patients carries out observation and compares, treatment group 58 example patient, and 42 examples are cured, 15 examples take a turn for the better, and 1 example does not heals, total effective rate 98.3%, matched group 58 example patient, and 17 examples are cured, and 20 examples take a turn for the better, 21 examples Not healing, total effective rate 63.8%, concrete clinical efficacy the results are shown in Table 1.
1. liang of table group Clinical efficacy comparison
Group n Cure Cure rate Take a turn for the better Improvement rate Do not heal Total effective rate
Matched group 58 42 72.4% 15 25.9% 1 98.3%
Treatment group 58 17 29.3% 20 34.5% 21 63.8%
The above results shows, after cold-dampness type patients with lumbar disc herniation the application of the invention nursing Drug therapy, symptom can To significantly improve, it addition, treatment group rear body weight before the treatment, heart rate, blood pressure are showed no substantially change.Treatment group exists Whole therapeutic process does not finds obvious adverse events.Thus illustrate that nursing medicine of the present invention is in treatment prolapse of lumbar intervertebral disc Particularly determined curative effect in terms for the treatment of cold-dampness type prolapse of lumbar intervertebral disc, safety is high, can be as cold-dampness type prolapse of lumbar intervertebral disc First-selected nursing medicine, is worth research popularization and application further.
The present invention, relative to prior art, has a following clear superiority:
Nursing medicament composing prescription of the present invention mainly develops according to the pathogenic characteristic of prolapse of lumbar intervertebral disc patient, it then follows the traditional Chinese medical science Compatibility theory, tuningout, toxicity processed, Rhizoma Et Radix Notopterygii, Radix Flemingiae Philippinensis, Herba Taxilli in side, invigorating the liver and kidney, muscle reinforcing and bone strengthening, expelling wind and removing dampness, Dispersing cold for relieving pain;Radix Clematidis, Herba Lycopodii, expelling wind and removing dampness, activating collaterals to relieve pain;Semen Persicae, Flos Carthami, blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia; Fructus Toosendan, the Rhizoma Pinelliae, promoting the circulation of QI to relieve pain, blood stasis dispelling eliminating stagnation.This pharmaceutically dosage form is advanced, and preparation is simple, is suitable for big technological process to produce, In prescription all medicines share have dispelling cold by warming the meridian, expelling wind and removing dampness, activating collaterals and eliminating stagnation, strong muscles and bones, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain it Special effect, has extremely strong pertinent nursing effect to prolapse of lumbar intervertebral disc especially cold-dampness type prolapse of lumbar intervertebral disc.By clinic application Checking, its determined curative effect, mild in medicine property and, toxic and side effects and untoward reaction do not occur, safety coefficient is high.
Further, in nursing medicine of the present invention, the function of each crude drug cures mainly:
Rhizoma Et Radix Notopterygii, pungent, bitter, temperature.Return bladder, kidney channel.Cold expelling, dispels the wind, dehumidifying, pain relieving.Have a headache for anemofrigid cold, Rheumatic arthralgia, aching pain in shoulder and back.
Semen Persicae, bitter, sweet, flat.GUIXIN, liver, large intestine channel.Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.For amenorrhea, dysmenorrhea, Abdominal mass mass in the abdomen, injury from falling down, dryness of the intestine constipation.
Flos Carthami, pungent, temperature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, Abdominal mass mass in the abdomen, injury from falling down, skin infection swells and ache.
Radix Clematidis, pungent, salty, temperature.Return bladder warp.Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.For rheumatic arthralgia, numb limbs and tense tendons, Muscle arteries and veins contracture, joint stuffiness, bone is choked with sobs larynx.
Fructus Toosendan, bitter, cold;Slightly poisonous.Return liver, small intestinal, bladder warp.Soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic.Coerce for breast, Abdominal distention, colic, abdominal pain due to worm stagnation.
Radix Flemingiae Philippinensis, sweet, tepor, flat.Wind-damp dispelling, strong waist knee joint.For rheumatic arthritis, lumbago and skelalgia, lumbar muscle strain, Leucorrhea, traumatic injury.
Herba Lycopodii, micro-hardship, pungent, temperature.Return liver,spleen,kidney warp.Expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, bend It is unfavorable to stretch.
The Rhizoma Pinelliae, pungent, temperature;Poisonous.Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration Cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomits regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus;Raw with external treatment carbuncle expectorant Core.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.
Herba Taxilli, bitter, sweet, flat.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit.For rheumatism numbness Bitterly, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement;Hypertension.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to specific examples below.? In the scope of the present invention or without departing from present disclosure, spirit and scope, change that the present invention is carried out, combination Or replace, will be apparent to the person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 unguentum
The each raw material of the present invention is weighed: Rhizoma Et Radix Notopterygii 15g, Radix Flemingiae Philippinensis 10g, Herba Taxilli 8g, Radix Clematidis 12g by following weight proportion, Herba Lycopodii 9g, Semen Persicae 10g, Flos Carthami 6g, Fructus Toosendan 8g, Rhizoma Pinelliae 5g.
Preparation technology is as follows:
Weigh above Chinese medicine component according to aforesaid weight, decoct 2 times after soaking 2.5h after mix homogeneously, add medicine total every time The water that weight is 7 times, decocts 2.5 hours, merges decoction liquor, filters;When filtrate concentrates 75 DEG C, relative density is 1.11-1.21 Extractum, make unguentum through normal process steps.
When using the present invention to nurse by Drug therapy prolapse of lumbar intervertebral disc, use prepared ointment, apply trouble the most gently Place, every day 3-4 time.
Embodiment 2 lotion
The each raw material of the present invention is weighed: Rhizoma Et Radix Notopterygii 15g, Radix Flemingiae Philippinensis 10g, Herba Taxilli 8g, Radix Clematidis 12g by following weight proportion, Herba Lycopodii 9g, Semen Persicae 10g, Flos Carthami 6g, Fructus Toosendan 8g, Rhizoma Pinelliae 5g.
Preparation technology is as follows:
Weigh above Chinese medicine component according to aforesaid weight, decoct 3 times after soaking 2.5h after mix homogeneously, add medicine total every time The water that weight is 7 times, decocts 2.5 hours, merges decoction liquor, filters;When filtrate concentrates 75 DEG C, relative density is 1.11-1.21 Extractum, make lotion through normal process steps.
When using the present invention to nurse by Drug therapy prolapse of lumbar intervertebral disc, use prepared lotion, the most gently soak affected part 15-20min, every day 3-4 time.
Embodiment 3 unguentum
The each raw material of the present invention is weighed: Rhizoma Et Radix Notopterygii 14g, Radix Flemingiae Philippinensis 8g, Herba Taxilli 7g, Radix Clematidis 11g by following weight proportion, Herba Lycopodii 8g, Semen Persicae 8g, Flos Carthami 5g, Fructus Toosendan 7g, Rhizoma Pinelliae 4g.
Preparation technology is as follows:
Weigh above Chinese medicine component according to aforesaid weight, decoct 2 times after soaking 3h after mix homogeneously, add medicine gross weight every time Measure the water of 8 times, decoct 3 hours, merge decoction liquor, filter;When filtrate concentrates 75 DEG C, relative density is the leaching of 1.11-1.21 Cream, makes unguentum through normal process steps.
When using the present invention to nurse by Drug therapy prolapse of lumbar intervertebral disc, use prepared liniment, apply affected part the most gently, Every day 3-4 time.
Embodiment 4 unguentum
The each raw material of the present invention is weighed: Rhizoma Et Radix Notopterygii 16g, Radix Flemingiae Philippinensis 12g, Herba Taxilli 8g, Radix Clematidis 12g by following weight proportion, Herba Lycopodii 10g, Semen Persicae 12g, Flos Carthami 7g, Fructus Toosendan 8g, Rhizoma Pinelliae 6g.
Preparation technology is as follows:
Weigh above Chinese medicine component according to aforesaid weight, decoct 3 times after soaking 2h after mix homogeneously, add medicine gross weight every time Measure the water of 6 times, decoct 2 hours, merge decoction liquor, filter;When filtrate concentrates 75 DEG C, relative density is the leaching of 1.11-1.21 Cream, makes unguentum through normal process steps.
When using the present invention to nurse by Drug therapy prolapse of lumbar intervertebral disc, use prepared ointment, apply trouble the most gently Place, every day 3-4 time.
Embodiment 5 unguentum
Weigh each raw material of the present invention by following weight proportion: Rhizoma Et Radix Notopterygii 10g, Radix Flemingiae Philippinensis 5g, Herba Taxilli 5g, Radix Clematidis 8g, stretch Muscle grass 5g, Semen Persicae 5g, Flos Carthami 3g, Fructus Toosendan 5g, Rhizoma Pinelliae 1g.
Preparation technology is as follows:
Weigh above Chinese medicine component according to aforesaid weight, decoct 2 times after soaking 2.5h after mix homogeneously, add medicine total every time The water that weight is 8 times, decocts 3 hours, merges decoction liquor, filters;When filtrate concentrates 75 DEG C, relative density is 1.11-1.21's Extractum, makes unguentum through normal process steps.
When using the present invention to nurse by Drug therapy prolapse of lumbar intervertebral disc, use prepared ointment, apply trouble the most gently Place, every day 3-4 time.
Embodiment 6 unguentum
The each raw material of the present invention is weighed: Rhizoma Et Radix Notopterygii 20g, Radix Flemingiae Philippinensis 15g, Herba Taxilli 10g, Radix Clematidis 16g by following weight proportion, Herba Lycopodii 15g, Semen Persicae 15g, Flos Carthami 8g, Fructus Toosendan 12g, Rhizoma Pinelliae 10g.
Preparation technology is as follows:
Weigh above Chinese medicine component according to aforesaid weight, decoct 3 times after soaking 2.5h after mix homogeneously, add medicine total every time The water that weight is 8 times, decocts 2 hours, merges decoction liquor, filters;When filtrate concentrates 75 DEG C, relative density is 1.11-1.21's Extractum, makes unguentum through normal process steps.
When using the present invention to nurse by Drug therapy prolapse of lumbar intervertebral disc, use prepared ointment, apply trouble the most gently Place, every day 3-4 time.

Claims (7)

1. the nursing medicine treating prolapse of lumbar intervertebral disc, it is characterised in that the composition and ratio of its crude drug is: Rhizoma Et Radix Notopterygii 10-20g, Radix Flemingiae Philippinensis 5-15g, Herba Taxilli 5-10g, Radix Clematidis 8-16g, Herba Lycopodii 5-15g, Semen Persicae 5-15g, Flos Carthami 3-8g, Fructus Toosendan 5-12g, Rhizoma Pinelliae 1-10g;External preparation made by described nursing medicine.
A kind of nursing medicine treating prolapse of lumbar intervertebral disc, it is characterised in that its crude drug Composition and ratio is: Rhizoma Et Radix Notopterygii 14-16g, Radix Flemingiae Philippinensis 8-12g, Herba Taxilli 7-8g, Radix Clematidis 11-12g, Herba Lycopodii 8-10g, Fructus Persicae Core 8-12g, Flos Carthami 5-7g, Fructus Toosendan 7-8g, Rhizoma Pinelliae 4-6g.
A kind of nursing medicine treating prolapse of lumbar intervertebral disc, it is characterised in that its crude drug Composition and ratio is: Rhizoma Et Radix Notopterygii 15g, Radix Flemingiae Philippinensis 10g, Herba Taxilli 8g, Radix Clematidis 12g, Herba Lycopodii 9g, Semen Persicae 10g, Flos Carthami 6g, Fructus Toosendan 8g, Rhizoma Pinelliae 5g.
4. a kind of nursing medicine treating prolapse of lumbar intervertebral disc as described in claim 1-3 is arbitrary, it is characterised in that described The preparation method of medicine comprises the steps of: weigh above Chinese medicine component according to aforesaid weight, soaks 2-3h after mix homogeneously Rear decoction 2-3 time, adds the water of medicine gross weight 6-8 times every time, decocts 2-3 hour, merges decoction liquor, filters;Filtrate is dense Contract 75 DEG C time relative density be the extractum of 1.11-1.21.
A kind of nursing medicine treating prolapse of lumbar intervertebral disc, it is characterised in that described external system Agent is fumigation and washing agent or unguentum.
6. the purposes in the medicine of preparation treatment prolapse of lumbar intervertebral disc of the nursing medicine as described in claim 1-3 is arbitrary.
7. the use in the medicine of preparation treatment cold-dampness type prolapse of lumbar intervertebral disc of the nursing medicine as described in claim 1-3 is arbitrary On the way.
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