CN103990016B - The Chinese medicine composition and its preparation and preparation method for the treatment of rheumatism bone disease - Google Patents
The Chinese medicine composition and its preparation and preparation method for the treatment of rheumatism bone disease Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine compositions for treating rheumatism bone disease, include the raw material of following ratio of weight and number：28 30 parts of Rhizoma Gastrodiae, 39 41 parts of smilax, 8 10 parts of caulis sinomenii, 14 16 parts of Rhizoma Arisaematis (processed), 8 10 parts of scorpio, 28 32 parts of Radix Paeoniae Alba, 38 40 parts of coix seed, 14 16 parts of the rhizome of davallia.The present composition can pain, arrested anxious caused by treat wind, cold, wet retardance muscle muscles and bones joint, song is stretched unfavorable, swelling, numbness, diseases such as tongue is dark, tongue is white, arteries and veins delays.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to treats the Chinese medicine of rheumatoid arthritis, muscular strain, osteoarthritis
Composition and its preparation and preparation method.
Background technology
Rheumatoid arthritis is a kind of systemic autoimmune diseases characterized by chronic erosive arthritis.Its lesion is special
Point is synovitis and the articular cartilage thereby resulted in and destruction of bone, eventually leads to joint deformity.If it is controlled without regular
It treats, deformity occurred in 3 years in about 75% patient.Rheumatoid arthritis is distributed in all over the world, and total number of patients in China exceedes
5000000.
Osteoarthritis is common with middle-older patient, and women is more than male.Illness rate is up to 50% in the crowd of 60 years old or more,
The crowd of 75 years old is then up to 80%.The disability rate of the disease may be up to 53%.Osteoarthritis is apt to occur in joint big, more than activity of bearing a heavy burden, such as
Knee, backbone（Cervical vertebra and lumbar vertebrae）, hip, ankle, the joints such as hand, be a kind of common disease, influence degree and institute to human health
The medical expense of consumption is continuously increased.
Muscular strain is a kind of chronic fine damage accumulated repeatedly, is substantially a kind of aseptic inflammation, is apt to occur in branch
With more dynamic or weight-bearing joints muscle or maintain the ligament in these joints, the especially attachment point of muscle or ligament on sclerotin.
Pain, tenderness and dysfunction can be caused to patient, seriously affect quality of life.To chronic muscular strain treatment, always with
Come based on oral drug therapy.
Rheumatoid arthritis, muscular strain, osteoarthritis are clinical common frdquently encountered disease, and pathogenesis is complicated, also lacks
Weary radical cure and the effective measures of prevention.Therefore it controlling inflammation, the swelling and pain of mitigation patient articular's muscle, contraction, song stretch the symptoms such as unfavorable,
The development of disease is controlled, prevents and subtracts pauciarticular destruction, keeps the function of affected joints as far as possible, oneself is promoted to destroy joint
It repairs, and the quality of life for improving its function and raising patient is still the main purpose treated at present.
Because such disease incidence mechanism is sufficiently complex, be used alone any drug be all difficult to block it is this mostly because
Disease development caused by plain, more pathologic processes, it is therefore desirable to use two or more mechanism of action, Effect path and adverse reaction
Different Drug combinations mitigates pain, inhibition synovial membrane inflammation to reach, prevents joint injury, maintain long-term remission, reach
To the purpose at a specified future date for improving, mitigating toxicity.Although clinically there are many treatment rheumatoid, muscular strain, osteoarthritis etc. at present
Although the Chinese medicine preparation of illness with certain curative effect, is a lack of wholistic therapy, therefore, a kind of effectively treatment wind of active demand
The Chinese medicine composition of wet osteopathy.
Invention content
The purpose of the present invention is to provide a kind of Chinese medicine composition for treating rheumatism bone disease, can by multipath, too many levels,
Multiple target point plays Integrate adjustment effect, and wholistic therapy is carried out for multiple pathology links of above-mentioned illness.The present invention also provides
A kind of preparation of above-mentioned composition and preparation method thereof.
Compared with prior art, the technical solution used in the present invention is：
A kind of Chinese medicine composition for treating rheumatism bone disease includes the raw material of following ratio of weight and number：
28-30 parts of Rhizoma Gastrodiae, 39-41 parts of smilax, 8-10 parts of caulis sinomenii, 14-16 parts of Rhizoma Arisaematis (processed), 8-10 parts of scorpio, Radix Paeoniae Alba
28-32 parts, 38-40 parts of coix seed, 14-16 parts of the rhizome of davallia.
Preferably, above-mentioned Chinese medicine composition, include the raw material of following ratio of weight and number：
30 parts of Rhizoma Gastrodiae, 40 parts of smilax, 10 parts of caulis sinomenii, 15 parts of Rhizoma Arisaematis (processed), 10 parts of scorpio, 30 parts of Radix Paeoniae Alba, coix seed 40
Part, 15 parts of the rhizome of davallia.
A kind of preparation of above-mentioned Chinese medicine composition, selected from capsule, tablet, mixture, syrup, oral pastes, powder, punching
Agent, pill and decoction.
Preferably, above-mentioned preparation is capsule.
A kind of preparation method of above-mentioned capsule, specifically comprises the following steps：
Step (1) dries scorpio full dose, adds in Radix Paeoniae Alba, each half of smilax total amount, and fineness is made as 80 purposes in crushing
Powders A；
Step (2) again soaks remaining each taste medicine 1 hour, decocting 2 times, and 2.5 hours for the first time, 2 is small for the second time
When, it is 2 hours every time, collecting decoction, filtration, the clear cream B that it is 1.3-1.4 relative to the density of water that filtrate, which is concentrated into, i.e., clearly
The density of cream B is 1.3-1.4g/mL.
Clear cream B in 65 DEG C of -75 DEG C of dries pulverizings, is added in A powder and starch mixing that step (1) obtains by step (3),
80 mesh sieve is crossed, it is encapsulated.
In the specific embodiment of the present invention, the loading of capsule is 0.45 gram.
In the specific embodiment of the present invention, the addition of starch is the 10-14% of capsule loading.
Rheumatism bone disease of the present invention includes：Rheumatoid arthritis, muscular strain, osteoarthritis.
In the present invention：
Rhizome of davallia bitter, it is warm-natured, return kidney, Liver Channel.With channels sootheing and network vessel quickening, the effect of dispelling wind and eliminating dampness, strong bone relieves pain, wind is cured mainly
It is wet with the passing of time, the weak card of caused by liver and kidney deficiency, lumbocrural pain, stride, be monarch drug in a prescription.
Caulis sinomenii bitter, pungent, mild-natured, Return liver, the spleen channel.With channels sootheing and network vessel quickening, the effect of dispelling wind and eliminating dampness, tonneau urine.
Its channels sootheing and network vessel quickening is taken in we, the work(of dispelling wind and eliminating dampness, for treating arthralgia pain due to rheumatism, itch is benumbed in arthroncus；Scorpio acrid flavour,
It is mild-natured, toxic, return liver warp.With relieving convulsion and spasm, dispersing pathogen accumulation, the effect of removing obstruction in channels to relieve pain.The product are good at removing obstruction in channels to relieve pain, to chill
Arthritis with fixed pain caused by dampness obstinate, muscle arteries and veins contraction, very then the stupid numbness of dysarthrasis, effect are rather good；It is Rhizoma Arisaematis (processed) bitter, pungent, it is warm-natured, return lung, liver,
The spleen channel.With eliminating dampness and eliminating phlegm, expelling wind and relieving convulsion, the effect of dissolving lump and resolving mass, swelling and pain relieving.Three medicines are altogether ministerial drug to channels sootheing and network vessel quickening,
Vanishing sputum and dispelling knot, stopping numbness pain.
Smilax slightly sweet flavor, mild-natured, Return liver, stomach, the spleen channel.With removing toxic substances, the effect of dehumidifying, sharp joint.It is taken in we
It dehumidifies, the work(in sharp joint, to treat limbs contraction, arthralgia and myalgia；Rhizoma Gastrodiae is sweet in flavor, mild-natured, return liver warp, has and relieves dizziness, high fever, infantile convulsions, epilepsy, etc. only
Convulsion, it is calming the liver, the effect of dispelling wind and removing obstruction in the meridians, the work(of its dispelling wind and removing obstruction in the meridians is taken in we, to wind-damp dispelling, stopping numbness pain；Coix seed
It is sweet in flavor, light, cold nature, returns spleen, stomach, lung, large intestine channel.With clearing damp and promoting diuresis, invigorating the spleen to arrest diarrhea, clearing damp eliminating impediment, the work(of clearing away heat and eliminating pus
Effect.The work(of its clearing damp eliminating impediment is taken in we, to treat arthralgia pain due to rheumatism, Spasm of the tendons, joint joint stuffiness；Radix Paeoniae Alba bitter,
Acid, cold nature enter liver, the spleen channel.The moon is held back with enriching blood, the effect of nourishing blood and liver, relieving spasm to stop pain.Radix Paeoniae Alba and smilax, Rhizoma Gastrodiae, the heart of a lotus seed
The seed of jog's tears shares, and acid receives sweet slow, unimpeded blood vessels, can enhance channels sootheing and network vessel quickening, vanishing sputum and dispelling knot, strong bone analgesic work(.More than smilax, day
Fiber crops, coix seed, Radix Paeoniae Alba are adjutant altogether.
Compared with prior art, what the present invention obtained has the beneficial effect that：
All medicines share of the present invention, play altogether channels sootheing and network vessel quickening, vanishing sputum and dispelling knot, strong bone analgesic work(, to treat wind, cold, wet resistance
Pain, arrested anxious caused by stagnant muscle muscles and bones joint, song is stretched unfavorable, swelling, numbness, the diseases such as tongue is dark, tongue is white, arteries and veins delays and class wind
Wet arthritis, osteoarthritis, muscular strain etc. cause above-mentioned symptom person.
Specific embodiment
We, by clinical practice and experimental study, develop in previous clinical observation and Research foundation and treat the disease
Active drug.The drug category pure Chinese medicine compound preparation, tool is anti-inflammatory, analgesia, adjusts immunization.It is by multipath, polycyclic
Section, multiple target point play Integrate adjustment effect, carry out wholistic therapy for multiple pathology links of rheumatism bone disease, achieve definite treatment
Effect.
The present invention is described in more detail below in conjunction with specific embodiment.
Embodiment 1
A kind of Chinese medicine composition for treating rheumatoid arthritis, muscular strain, osteoarthritis, including following parts by weight
The raw material of number ratio：28 parts of Rhizoma Gastrodiae, 39 parts of smilax, 8 parts of caulis sinomenii, 14 parts of Rhizoma Arisaematis (processed), 8 parts of scorpio, 28 parts of Radix Paeoniae Alba, coix seed 38
Part, 14 parts of the rhizome of davallia.
Above-mentioned Chinese medicine composition is prepared into capsule, specific method is as follows：
Step (1) dries scorpio full dose, adds in Radix Paeoniae Alba, each half of smilax total amount, and fineness is made as 80 purposes in crushing
Powders A；
Step (2) again soaks remaining each taste medicine 1 hour, decocting 2 times, and 2.5 hours for the first time, 2 is small for the second time
When, it is 2 hours every time, collecting decoction filters, and filtrate is concentrated into the clear cream B that density is 1.3-1.4g/mL；
Clear cream B in 65 DEG C of -75 DEG C of dries pulverizings, is added in A powder and be equivalent to total amount that step (1) obtains by step (3)
10% starch mixing, crosses 80 mesh sieve, and every 0.45g is encapsulated.
Embodiment 2
A kind of Chinese medicine composition for treating rheumatoid arthritis, muscular strain, osteoarthritis, including following parts by weight
The raw material of number ratio：29 parts of Rhizoma Gastrodiae, 40 parts of smilax, 9 parts of caulis sinomenii, 15 parts of Rhizoma Arisaematis (processed), 9 parts of scorpio, 30 parts of Radix Paeoniae Alba, coix seed 39
Part, 15 parts of the rhizome of davallia.
Above-mentioned Chinese medicine composition is prepared into capsule, specific method is as follows：
Step (1) dries scorpio full dose, adds in Radix Paeoniae Alba, each half of smilax total amount, fineness is made as 80 mesh in crushing
Powders A；
Step (2) again soaks remaining each taste medicine 1 hour, decocting 2 times, and 2.5 hours for the first time, 2 is small for the second time
When, it is 2 hours every time, collecting decoction filters, and filtrate is concentrated into the clear cream B that density is 1.3-1.4g/mL；
Clear cream B in 65 DEG C of -75 DEG C of dries pulverizings, is added in A powder and be equivalent to total amount that step (1) obtains by step (3)
14% starch mixing, crosses 80 mesh sieve, and every 0.45g is encapsulated.
Embodiment 3
A kind of Chinese medicine composition for treating rheumatoid arthritis, muscular strain, osteoarthritis, including following parts by weight
The raw material of number ratio：30 parts of Rhizoma Gastrodiae, 41 parts of smilax, 10 parts of caulis sinomenii, 16 parts of Rhizoma Arisaematis (processed), 10 parts of scorpio, 32 parts of Radix Paeoniae Alba, coix seed
40 parts, 16 parts of the rhizome of davallia.
Above-mentioned Chinese medicine composition is prepared into capsule, specific method is as follows：
Step (1) dries scorpio full dose, adds in Radix Paeoniae Alba, each half of smilax total amount, and fineness is made as 80 purposes in crushing
Powders A；
Step (2) again soaks remaining each taste medicine 1 hour, decocting 2 times, and 2.5 hours for the first time, 2 is small for the second time
When, it is 2 hours every time, collecting decoction filters, and filtrate is concentrated into the clear cream B that density is 1.3-1.4g/mL；
Clear cream B in 65 DEG C of -75 DEG C of dries pulverizings, is added in A powder and be equivalent to total amount that step (1) obtains by step (3)
12% starch mixing, crosses 80 mesh sieve, and every 0.45g is encapsulated.
Embodiment 4
A kind of Chinese medicine composition for treating rheumatoid arthritis, muscular strain, osteoarthritis, including following parts by weight
The raw material of number ratio：30 parts of Rhizoma Gastrodiae, 40 parts of smilax, 10 parts of caulis sinomenii, 15 parts of Rhizoma Arisaematis (processed), 10 parts of scorpio, 30 parts of Radix Paeoniae Alba, coix seed
40 parts, 15 parts of the rhizome of davallia.
Above-mentioned Chinese medicine composition is prepared into capsule, specific method is as follows：
Step (1) dries scorpio full dose, adds in Radix Paeoniae Alba, each half of smilax total amount, and fineness is made as 80 purposes in crushing
Powders A；
Step (2) again soaks remaining each taste medicine 1 hour, decocting 2 times, and 2.5 hours for the first time, 2 is small for the second time
When, it is 2 hours every time, collecting decoction filters, and filtrate is concentrated into the clear cream B that density is 1.3-1.4g/mL；
Clear cream B in 65 DEG C of -75 DEG C of dries pulverizings, is added in A powder and suitable total amount that step (1) obtains by step (3)
10% starch mixing, crosses 80 mesh sieve, and every 0.45g is encapsulated.
Comparative example 1
According to《The research of strong bone bracelet pain capsule quality standard》（Chinese experimental pharmacology of traditional Chinese medical formulae magazine, 2007,13 (2):4-5.）
Prescription in the Chinese medicine composition of the treatment rheumatism of middle announcement, adopts and is prepared into capsule using the preparation method of capsule of the present invention.Tool
Body includes the raw material of following ratio of weight and number：15 parts of tripterygium wilfordii, 15 parts of Rhizoma Gastrodiae, 10 parts of scorpio, 10 parts of caulis sinomenii, Rhizoma Arisaematis (processed) 15
Part, 15 parts of the rhizome of davallia, 40 parts of coix seed, 40 parts of smilax, 15 parts of Radix Paeoniae Alba.
Above-mentioned Chinese medicine composition is prepared into capsule, specific method is as follows：
Step (1) dries scorpio, smilax total amount half, and fineness is made as 80 mesh powder A in crushing；
Step (2) again soaks remaining each taste medicine 1 hour, decocting 2 times, and 2.5 hours for the first time, 2 is small for the second time
When, it is 2 hours every time, collecting decoction filters, and filtrate is concentrated into the clear cream B that relative density is 1.3-1.4；
Clear cream B in 65 DEG C of -75 DEG C of dries pulverizings, is added in A powder and be equivalent to total amount that step (1) obtains by step (3)
10% starch mixing, crosses 80 mesh sieve, and every 0.45g is encapsulated.
Effect example 1
Capsule preparations described in comparative example 1 and embodiment 3 are subjected to laboratory test comparison, investigate its effect and side effect.
Method：Experimental group and control group are taken respectively from 83, the court rheumatoid arthritis outpatient, 43 people of experimental group,
3 capsule preparations of case study on implementation of the present invention are taken, control group takes the made capsule of comparative example 1, takes orally 5-6 tablets/time, one day 3
It is secondary, it takes medicine 15-90 days, it is 60 days average.The basic documents such as the age of two groups of research objects, the course of disease are compared, through statistics
Analysis, the no significance difference opposite sex (P>0. 05), and research object is comparable.
Concrete outcome is shown in Tables 1 and 2.
Contrast test shows embodiment 3 to increase Radix Paeoniae Alba dosage, rejects the larger tripterygium wilfordii of toxic side effect, and tripterygium wilfordii is
Big poison Chinese medicine can generate the adverse reactions such as nausea, diarrhea, vomiting, blood pressure reduction, patient body is impacted, is increased with Radix Paeoniae Alba
Amount rejects tripterygium wilfordii and ensures to reduce adverse drug reaction while curative effect, and it is apparent low that clinical trial shows that this patent prescription has
Toxicity.Prove that prescription of the present invention reduces adverse reaction while curative effect is ensured.Compared with comparative example 1 prescription have it is bright
Aobvious advantage.
Test example 1 Chinese medicinal composition capsules of the present invention treatment rheumatoid arthritis, muscular strain, osteoarthritis are faced
Bed test statistics data
First, patient's general information
The all our hospital outpatients of 212 patients.Age 6-86 Sui, averagely 41.22 ± 16.37 years old, wherein male 61
Example, women 151, the course of disease is most 1 month short, longest 30 years.
2nd, patient's general information is analyzed
In the patient of capsule clinical practice of the present invention, vocational distribution come first 5 be worker, driver, peasant, sale and
From moving back, the 90.1% of total number of cases are accounted for；Disease publication mainly rheumatoid arthritis, muscular strain, osteoarthritis.It is shown in Table 3.
3rd, testing program
Treatment group's medication：Capsule prepared by the embodiment of the present invention 4, specification：0.45g/
The course for the treatment of：It is oral, 5-6 tablets/time, 3 times a day
4th, curative effect determinate standard
1st, rheumatoid arthritis：
It is effective：Affected joints are clearly better or disappear, and erythrocyte sedimentation rate, rheumatoid factor reduce or erythrocyte sedimentation rate, rheumatoid factor are extensive
It is multiple normal.
Effectively：Affected joints or swelling and pain take a favorable turn after treatment.
In vain：Through 1~3 course for the treatment of of treatment (every course for the treatment of 30 days), affected joints swell and ache without improvement.
2nd, muscular strain
It is effective：Pain symptom disappears, and the activity of painful area portion is freely.
Effectively：Pain relief, nociceptive activity function are restored substantially.
In vain：Symptom does not improve.
3rd, osteoarthritis（With reference to new Chinese medicine clinical guidance principle）
It is effective：The symptoms such as pain disappear, and joint motion is unrestricted, and integration reduces >=70%, ＜ 95%；Effectively：The diseases such as pain
Shape disappears substantially, and joint motion is slightly limited, and integration reduces >=30%, ＜ 70%；
In vain：The symptoms such as pain are not improved with joint motion, and integration reduces ＜ 30%.
Calculation formula (Nimodipine method)：Integration × 100% before (being integrated after integration-treatment before treatment)/treatment.
5th, clinical efficacy situation analysis
It is 85.5%, to muscular strain to the effective percentage for improving rheumatoid arthritis in the clinical treatment of all patients
Effective percentage be 92.5%, be 66.7% to osteoarthritis effective percentage.It is shown in Table 4.
6th, capsule service condition is analyzed
Clinical practice shows average day dosage at 18, and minimum dosage is 15, and maximum dosage is 21
Grain；Average usage time is 40 days, and most short to use 25 days, longest uses 90 days；Total dosage average out to 720, minimum makes
With 375,1890 are at most used.Refer to table 5.
7th, clinical practice safety analysis
We give much attention to this capsule safety observations in process of clinical application, and the allergy that patient does not occur whole body is anti-
Adverse reactions should be waited, long-time operation instruction this capsule clinical practice is safe and reliable.By literature search, other safety are not found
Sex chromosome mosaicism.
8th, Clinical Application Analysis
Pass through the clinical observation of more complete case history, it was demonstrated that this capsule to improve rheumatoid arthritis effective percentage be
85.5%th, it is 92.5% to the effective percentage of muscular strain, is 66.7% to osteoarthritis effective percentage.Clinical practice analysis shows, this glue
Capsule Clinical practice crowd is extensive, application time is long, treatment disease is more, clinical efficacy is good, adverse reaction is extremely low, is to be worthy to be popularized to answer
With safely and effectively Chinese medicinal capsule preparation.
Its model case is as follows：
Case 1
Ni so-and-so, female, 42 years old, driver.First visit in January, 2011 tells that extremities joint is ached unfavorable 10 years of activity, once went to a doctor in
Hebei Prov. Traditional Chinese Medicine Hospital, through every laboratory examination（It is unknown）It is diagnosed as rheumatoid arthritis.After treatment, weight when symptom is light, instead
Recurrence is made.Over nearly 3 days, extremities joint pain aggravates after fatigue, meets cold-dampness then more so, pain alleviated while getting warmth, to examine.Look into patient's both hands,
Double wrist joints are ached, and are held object and are limited, it is impossible to be clenched fist, accessible subcutaneous nodule, duplex, double knees, double ankle-joints are ached, active receiving
Limit, difficulty of squatting down；X-ray film shows：Double wrist joint changes meet rheumatoid arthritis.Laboratory examination shows：ASO 189IU/ml, RF
181.9IU/ml, CRP 42.2mg/L, hepatic and renal function no abnormality seen, electrocardiogram no abnormality seen.It is diagnosed as：Rheumatoid arthritis.
Patient's extremities joint is ached, and meets cold-dampness more so, pain alleviated while getting warmth, local swelling, and activity is unfavorable, and joint arrested anxious, local color of the leather is not red,
That touches is not hot, and pain aggravates after fatigue, and clear abundant urine, the dark tongue of tongue is white, deep tense pulse.It is dialectical obstructed for grain, phlegm wet numbness resistance card.It controls
With channels sootheing and network vessel quickening, vanishing sputum and dispelling knot, strong bone analgesic method.Capsule oral of the present invention is given, 6 tablets each time, 3 times a day.Treatment 2 weeks
Afterwards, patient's extremities joint ache is substantially reduced；After treating 8 weeks, patient activity freely, is evaluated with treating rheumatoid arthritis standard
To be effective, follow-up no relapse.
Case 2
It is military so-and-so, female, 60 years old, retired worker.The first visit of in September, 2011, tells double knee joint pain 5 years, dysarthrasis activity
It is 3 years limited, it once went to a doctor in the Second Academy of province, and gave treatments, the effects such as oral drugs, external plaster volt bad.Dysarthrasis before 3 years, it is living
Dynamic limited, double knee joint gradually appears valgus deformity.Double knee pain aggravate before January, and activity is unfavorable, to examine.The double knees of patient are looked into close
Save pain, swelling, when it is light when weight, double in knee, joint stuffiness, with clicking of joint.X pieces show：Knee joint epiphysis has spur to be formed,
Shin lateral joint gap turn narrow, intercondylar ridge come to a point, and lower edge comes to a point on kneecap, and kneecap upper limb has tenostosis shadow.Laboratory examination and
ECG examination no abnormality seen.It is diagnosed as：Double knee osteoarthritis.Patient's shape is trembled with fear, and limb is cold, and soreness and weakness of waist and knees, waist-leg is unfavorable, bends and stretches
Pain on motion aggravates, and receives difference, and two, tongue secretly has petechia, and tongue is greasy in vain, deep thready pulse.It is dialectical obstructed for grain, blockage of phlegm and blood stasis,
Kidney deficiency and liver demonstrate,prove, control with relaxing tendons and activating collaterals, vanishing sputum and dispelling knot, strong bone analgesic method.Capsule oral of the present invention is given, 6 tablets each time, daily
3 times.After treating 1 week, patient's double knee joint pain pain is substantially reduced；After treating 6 weeks, patient activity freely, with Osteoarthritis
Treatment standard is evaluated as effective, follow-up no relapse.
Case 3
Mr. Wang, male, 61 years old, peasant.First visit in October, 2011, tells pain in the back 11 years, once goes to a doctor in local hospital, through looking into CT,
Erythrocyte sedimentation rate, rheumatoid factor, anti-O, urine examination etc. check no abnormality seen, are diagnosed as lumbar muscle strain.The medicines such as oral ibuprofen are given, it can be temporary
When relieve pain.Before 1 week, because weather turns cold, pain in the back aggravation, to examine.Patient's waist both sides pain adds after tired or when cloudy and clammy
Weight, patient's pale complexion, soreness and weakness of waist and knees, there are indentation, forceless deep pulse in greasy side to the dark tongue of tongue in vain.Chronic lumbar strain is diagnosed as, dialectical is muscle
Arteries and veins, which loses, supports, blockage of phlegm and blood stasis, kidney deficiency and liver card.It controls with relaxing tendons and activating collaterals, vanishing sputum and dispelling knot, the method for strong bone analgesic.Give capsule of the present invention
It is oral, 6 tablets each time, 3 times a day.After treating 1 week, the symptoms were significantly improved for patient's pain in the back；After treating 4 weeks, patient's pain in the back symptom disappears
It loses, follow-up no relapse.
Case 4
History so-and-so, man, 50 years old, worker.The first visit of in September, 2012 tells that metacarpophalangeal joints nociceptive activity is limited companion's morning stiffness more than 6 years,
It aggravates 2 months, once went to a doctor in local hospital, after treatment, weight when symptom is light.Over nearly 2 months, bilateral interphalangeal joint, metacarpophalangeal
Joint, elbow joint swelling, limitation of activity.X-ray shows：Both hands joint changes in rheumatoid arthritis, and articular surface bone density lowers,
Left hand hand middle finger and unknown proximal interphalangeal joint of finger gap turn narrow.Laboratory examination：ANA, anti-SSA antibody are positive, RF is positive,
ESR 38.00mm/h, cyclic citrullinated peptid are positive.Hepatic and renal function and ECG examination no abnormality seen.It is diagnosed as rheumatoid
Arthritis.Patient articular overflows swollen pain, and fixed pain, anchylosis deformation, joint stuffiness, mouth is dry, soreness and weakness of waist and knees, the purple dark tongue of tongue
It is greasy, deep thready pulse.Dialectical lost for tendon and vessel is supported, blockage of phlegm and blood stasis, kidney deficiency and liver card.It controls to control with relaxing tendons and activating collaterals, vanishing sputum and dispelling knot, strong bone is stopped
The method of pain.Capsule oral of the present invention is given, 6 tablets each time, 3 times a day.After treating 2 weeks, patient articular's pain symptom is clearly better；
After treating 7 weeks, patient articular's pain symptom disappears, follow-up no relapse.
Embodiment described above is merely a preferred embodiment of the present invention, and the simultaneously exhaustion of the feasible implementation of non-present invention.It is right
For persons skilled in the art, under the premise of without departing substantially from the principle of the invention and spirit to any aobvious made by it and
The change being clear to should be all contemplated as falling within the claims of the present invention.
Claims (7)
1. a kind of Chinese medicine composition for treating rheumatism bone disease, it is characterised in that：Its raw material by following ratio of weight and number is made：
28-30 parts of Rhizoma Gastrodiae, 39-41 parts of smilax, 8-10 parts of caulis sinomenii, 14-16 parts of Rhizoma Arisaematis (processed), 8-10 parts of scorpio, Radix Paeoniae Alba 28-32
Part, 38-40 parts of coix seed, 14-16 parts of the rhizome of davallia.
2. a kind of Chinese medicine composition for treating rheumatism bone disease according to claim 1, it is characterised in that：The Chinese traditional medicine composition
Object is made of the raw material of following ratio of weight and number：
30 parts of Rhizoma Gastrodiae, 40 parts of smilax, 10 parts of caulis sinomenii, 15 parts of Rhizoma Arisaematis (processed), 10 parts of scorpio, 30 parts of Radix Paeoniae Alba, 40 parts of coix seed, bone
It is broken to mend 15 parts.
3. a kind of preparation for including the Chinese medicine composition for the treatment of rheumatism bone disease described in claims 1 or 2, it is characterised in that：It is selected from
Capsule, tablet, mixture, syrup, oral pastes, powder, electuary, pill and decoction.
4. the preparation of the Chinese medicine composition for the treatment of rheumatism bone disease according to claim 3, it is characterised in that：For capsule.
5. a kind of preparation method of preparation as claimed in claim 4, it is characterised in that：
Step (1) dries scorpio full dose, adds in Radix Paeoniae Alba, each half of smilax total amount, and fineness is made as 80 mesh powders in crushing
A；
Step (2) soaks remaining each taste medicine 1 hour, decocting 2 times, 2.5 hours for the first time, second 2 hours, every time
It it is 2 hours, collecting decoction filters, and filtrate is concentrated into the clear cream B that density is 1.3-1.4g/mL；
Clear cream B in 65 DEG C of -75 DEG C of dries pulverizings, is added in A powder and starch mixing that step (1) obtains, crosses 80 mesh by step (3)
Sieve, it is encapsulated.
6. the preparation method of preparation according to claim 5, it is characterised in that：The loading of capsule is 0.45 gram.
7. the preparation method of preparation according to claim 5, it is characterised in that：The addition of the starch is filled for capsule
The 10-14% of amount.
Priority Applications (1)
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| CN1824262A (en) * | 2005-12-24 | 2006-08-30 | 周娅 | Chinese medicinal preparation for treating atrophic arthritis |
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| CN1824262A (en) * | 2005-12-24 | 2006-08-30 | 周娅 | Chinese medicinal preparation for treating atrophic arthritis |
Non-Patent Citations (3)
| Title |
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| 中成药治疗类风湿性关节炎近况;邓广业;《安徽中医临床杂志》;20010428;第13卷(第02期);第151-152页 * |
| 健骨蠲痛胶囊质量标准的研究;阎向东等;《中国实验方剂学杂志》;20070220;第13卷(第02期);第4-6页 * |
| 天星健骨方联合西药治疗类风湿关节炎120例临床观察;杨晓军等;《中医杂志》;20130515;第54卷(第10期);第849-851页 * |
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