CN113144018B - Traditional Chinese medicine composition for treating blunt injury of soft tissues and extract and application thereof - Google Patents
Traditional Chinese medicine composition for treating blunt injury of soft tissues and extract and application thereof Download PDFInfo
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- CN113144018B CN113144018B CN202110372591.5A CN202110372591A CN113144018B CN 113144018 B CN113144018 B CN 113144018B CN 202110372591 A CN202110372591 A CN 202110372591A CN 113144018 B CN113144018 B CN 113144018B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
The invention relates to a traditional Chinese medicine composition for treating blunt injury of soft tissues, an extract and application thereof, belonging to the technical field of medicines. The traditional Chinese medicine composition comprises the following components in parts by weight: 30-10 parts of ivy mucuna, 30-100 parts of herba potentillae kleinianae, 30-100 parts of pseudo-ginseng, 30-100 parts of angelica sinensis, 10-50 parts of salvia miltiorrhiza and 10-50 parts of safflower. The invention is based on the traditional Chinese medicine dialectical treatment, combines clinical practice to carry out scientific compatibility, supplements the medicines, and determines the optimal dosage of each traditional Chinese medicine through continuous exploration, so that the composition can effectively treat blunt injury of soft tissues such as strain, contusion and the like, can quickly relieve the state of an illness, and is safe without toxic or side effect.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for treating blunt injury of soft tissues, and an extract and application thereof.
Background
In daily life, due to the situations of excessive movement, improper force application, sudden accidents and the like, blunt injuries of soft tissues are often caused. The degree of injury is mild and severe, but the daily work and life are seriously affected due to pain and limited activity. At present, for blunt injuries of muscle and soft tissue such as muscle strain, soft tissue contusion and the like, traditional Chinese medicine acupuncture, massage, medicinal liquor, medicinal oil and other physical therapy methods are mostly adopted for rehabilitation, but the treatment time is long and the curative effects are different.
Disclosure of Invention
In view of the above, one of the objectives of the present invention is to provide a Chinese medicinal composition for treating blunt tissue injury, which has the advantages of simple compatibility, low cost and significant curative effect; the second purpose is to provide an extract of the traditional Chinese medicine composition for treating blunt injury of soft tissues; the third purpose is to provide a medicinal preparation taking the extract of the traditional Chinese medicine composition for treating the blunt injury of soft tissues as an active ingredient; the fourth purpose is to provide the application of the traditional Chinese medicine composition for treating the blunt injury of the soft tissue or the extract of the traditional Chinese medicine composition in preparing the medicine for treating the blunt injury of the soft tissue.
In order to achieve the purpose, the invention provides the following technical scheme:
1. a traditional Chinese medicine composition for treating blunt injury of soft tissues comprises the following components in parts by weight: 30-100 parts of ivy mucuna, 30-100 parts of herba potentillae kleinianae, 30-100 parts of pseudo-ginseng, 30-100 parts of angelica sinensis, 10-50 parts of salvia miltiorrhiza and 10-50 parts of safflower.
2. The extract of the traditional Chinese medicine composition for treating the blunt injury of the soft tissue.
Preferably, the extract is prepared by the following method: weighing caulis et folium Mucunae Hederae, herba Lysimachiae Foenumgraeci, Notoginseng radix, radix Angelicae sinensis, Saviae Miltiorrhizae radix, and Carthami flos according to a certain proportion, mincing the whole formula, adding into 60-80 vol% ethanol 2-4 times of the total weight of each medicinal material, soaking for 10-30 days, filtering, and collecting the extractive solution.
3. The external pharmaceutical preparation takes the extract of the traditional Chinese medicine composition for treating the blunt injury of the soft tissue as an active ingredient.
Preferably, the external pharmaceutical preparation is one of a spray, an ointment, a gel, a liniment, a paste or a patch.
4. The traditional Chinese medicine composition for treating the blunt injury of the soft tissue or the extract of the traditional Chinese medicine composition for treating the blunt injury of the soft tissue is applied to the preparation of the medicine for treating the blunt injury of the soft tissue.
The invention has the beneficial effects that: the invention provides a traditional Chinese medicine composition for treating blunt injury of soft tissues, and an extract and application thereof. Blunt injury is usually caused by direct or indirect trauma, and the injury is often accompanied by symptoms such as pain, swelling, blood stasis, etc. According to pathological analysis, the tissue is subjected to aseptic inflammation due to the fact that local tissue microcirculation disturbance is damaged, and accordingly pathological changes such as superficial and deep fascia swelling, muscle tendon and ligament ischemic contracture, joint internal and external adhesion stiffness and the like are caused. The analysis of Chinese medicine is the syndrome of obstruction of qi and blood and obstruction of collaterals by blood stasis. The treatment should be mainly based on relaxing muscles and tendons, dredging collaterals, promoting blood circulation and removing blood stasis. The traditional Chinese medicine is based on syndrome differentiation and treatment of the traditional Chinese medicine, and is scientifically combined with clinical practice, the medicines supplement each other, and the safflower in the formula is pungent and warm in nature and has the effects of promoting blood circulation to remove blood stasis, dissipating dampness and removing swelling, and relieving pain and carbuncle; notoginseng radix has hemostatic, blood stasis dispelling, microcirculation recovering, antiinflammatory, and analgesic effects; the red sage root promotes blood circulation, and strengthens the effects of dissipating blood stasis and easing pain; chinese angelica root, radix Angelicae sinensis promotes blood circulation and tonifies blood; the Hedera helix has warm and bitter taste, promotes blood circulation, and relieves inflammation of joint and tendon; herba Lysimachiae foenumgraeci with swelling and pain relieving effects. The composition has scientific components and reasonable compatibility, has better curative effect within the weight range, can effectively treat blunt injury of soft tissues such as strain, contusion and the like, can quickly relieve the illness state, and is safe without toxic or side effect.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention. The objectives and other advantages of the invention may be realized and attained by the means of the instrumentalities and combinations particularly pointed out hereinafter.
Detailed Description
The embodiments of the present invention are described below with reference to specific embodiments, and other advantages and effects of the present invention will be easily understood by those skilled in the art from the disclosure of the present specification. The invention is capable of other and different embodiments and of being practiced or of being carried out in various ways, and its several details are capable of modification in various respects, all without departing from the spirit and scope of the present invention.
Example 1
A traditional Chinese medicine composition for treating blunt injury of soft tissues comprises the following components in parts by weight: 55g of ivy mucuna stem, 50g of herba potentillae kleinianae, 30g of pseudo-ginseng, 30g of Chinese angelica, 15g of salvia miltiorrhiza and 15g of safflower.
The extract is prepared from the traditional Chinese medicine composition by the following method:
the extract of the traditional Chinese medicine composition for treating blunt injury of soft tissues is obtained by weighing the ivy, the herba potentillae chinensis, the pseudo-ginseng, the angelica, the salvia miltiorrhiza and the safflower according to the proportion, mincing the whole formula, adding the minced whole formula into 60 vol% ethanol 2 times of the total weight of all the medicinal materials, soaking for 15 days, filtering and collecting the extract.
Clinical case efficacy analysis
80 patients with blunt soft tissue injury of 25-65 years old and 1-3 days in disease course are randomly divided into 4 groups, which are respectively 20 physical method control groups, wherein 8 male patients and 12 female patients are selected; the traumatic oil control group comprises 20 cases, wherein 7 cases are male, and 13 cases are female; the traumatic injury plaster comprises 20 control groups, 7 male and 13 female; treatment groups 20, 7 males and 13 females. The comparative difference of the age, the sex and the attack course of the four groups of patients has no statistical significance (P is more than 0.05), and the patients have comparability.
The intervention method comprises the following steps: physical method control group adopts physical methods of baking lamp and cold/hot compress; the traumatic injury oil control group adopts a method of smearing traumatic injury oil; the control group of traumatic injury plaster adopts a method of applying traumatic injury plaster; the treatment group was treated by spraying the extract of example 1.
The curative effect standard is as follows: the recovery degree of pain and swelling (3 min), the activity of affected parts (3 min) and the stress of affected parts (3 min) are used as the basis for comprehensive evaluation of the effect (more than 7 min), effect (3-6 min) and ineffectiveness (less than 3 min).
The statistical method comprises the following steps: between group comparisons one-way analysis of variance was selected, and data was processed using the SPSS18.0 software. Test levels α of 0.05, P < 0.05 indicated statistical significance, and one-way anova was performed for each treatment group. The data for each group are shown in Table 1.
TABLE 1
| Obvious effect (example) | Effective (example) | Invalid (example) | |
| Physical method control group | 2 | 12 | 6 |
| Traumatic injury oil control group | 7 | 10 | 3 |
| Plaster for traumatic injury | 6 | 14 | 0 |
| Treatment group | 13 | 7 | 0 |
As can be seen from table 1, the effect of the treatment group was significant compared to other treatment methods, F is 19.336, and P is < 0.001.
Three groups of onset time statistics: the physical method has the slowest effect compared with the group, and the compliance of patients is poor; the effect of the control group of traumatic oil is achieved about 2 days after the control group of traumatic oil uses traumatic oil, and patients generally need 10+ days for recovery; the traumatic injury plaster takes effect about 1 day after the traumatic injury plaster is used, and the recovery of a patient needs 2+ weeks; treatment groups sprayed with the extract of example 1 provided relief of local symptoms within 1 day, and the patient required 7+ days of recovery.
Example 2
A traditional Chinese medicine composition for treating blunt injury of soft tissues comprises the following components in parts by weight: 50g of ivy mucuna, 40g of herba potentillae chinensis, 30g of pseudo-ginseng, 30g of angelica sinensis, 10g of salvia miltiorrhiza and 10g of safflower.
The extract is prepared from the traditional Chinese medicine composition by the following method:
the extract of the traditional Chinese medicine composition for treating blunt injury of soft tissues is obtained by weighing ivy, herba potentillae chinensis, pseudo-ginseng, angelica sinensis, salvia miltiorrhiza and safflower according to the proportion, chopping the whole formula, adding the chopped whole formula into ethanol with the weight 3 times of the total weight of the medicinal materials and 80 vol% for soaking for 10 days, and filtering and collecting the extract.
Clinical case efficacy analysis
Zhao, women, 56 years old, dancing and shoulder pain 3+ month. When a patient dances before 3+ month, the shoulder is injured due to improper force, the traumatic injury ointment (not detailed) is used for treating the patient, the symptom is slowly relieved, the patient repeatedly attacks in 3+ month, the patient gets worse after moving, the shoulder joint is limited in movement, the arm cannot be lifted, the symptom is relieved after 2 days after the extract in the embodiment 2 is sprayed, and the patient can move as usual at present.
Example 3
A traditional Chinese medicine composition for treating blunt injury of soft tissues comprises the following components in parts by weight: 50g of ivy mucuna, 55g of herba potentillae kleinianae, 30g of pseudo-ginseng, 35g of angelica sinensis, 10g of salvia miltiorrhiza and 10g of safflower.
The extract is prepared from the traditional Chinese medicine composition by the following method:
the extract of the traditional Chinese medicine composition for treating blunt injury of soft tissues is obtained by weighing ivy, herba potentillae chinensis, pseudo-ginseng, angelica sinensis, salvia miltiorrhiza and safflower according to the proportion, chopping the whole formula, adding the chopped whole formula into 70 vol% ethanol 4 times of the total weight of the medicinal materials, soaking for 10 days, filtering and collecting the extract.
Clinical case efficacy analysis
Li Jie, male, 30 years old, sprain of ball and ankle for 2 days. The ankle of the patient is accidentally sprained before the patient takes the ball 2 days ago, the ankle is red, swollen and painful after the injury, the force cannot be applied at all, the X-piece does not fracture, the red, swollen and painful after the extract in the embodiment 3 is sprayed are relieved, and the patient can normally move after the extract is used for one week.
Example 4
A traditional Chinese medicine composition for treating blunt injury of soft tissues comprises the following components in parts by weight: 50g of ivy mucuna, 50g of herba potentillae kleinianae, 35g of pseudo-ginseng, 35g of angelica sinensis, 15g of salvia miltiorrhiza and 15g of safflower.
The extract is prepared from the traditional Chinese medicine composition by the following method:
the extract of the traditional Chinese medicine composition for treating blunt injury of soft tissues is obtained by weighing the ivy, the herba potentillae chinensis, the pseudo-ginseng, the angelica, the salvia miltiorrhiza and the safflower according to the proportion, chopping the whole formula, adding the chopped whole formula into 60 vol% ethanol which is 2 times of the total weight of all the medicinal materials, soaking for 30 days, filtering and collecting the extract.
Clinical case efficacy analysis
In Zhouji, male, 37 years old, sprain the knee joint for 2 days, and the patient carelessly falls down from stairs 2 days before, and the knee joint is sprained inappropriately, and the knee joint is swollen and severe pain after injury, and the activity is limited, and the patient can not bear the force, and after the extract in the embodiment 4 is used for spraying, the severe pain is relieved to some extent, and after the extract is used for 7 days, the patient can basically move normally, and the knee joint can not bear the force temporarily.
Finally, the above embodiments are only intended to illustrate the technical solutions of the present invention and not to limit the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that modifications or equivalent substitutions may be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions, and all of them should be covered by the claims of the present invention.
Claims (6)
1. A traditional Chinese medicine composition for treating blunt injury of soft tissues is characterized by comprising the following components in parts by weight: 30-100 parts of ivy mucuna, 30-100 parts of herba potentillae kleinianae, 30-100 parts of pseudo-ginseng, 30-100 parts of angelica sinensis, 10-50 parts of salvia miltiorrhiza and 10-50 parts of safflower.
2. The extract of the Chinese medicinal composition for treating blunt injury of soft tissues of claim 1.
3. The extract of the traditional Chinese medicine composition for treating blunt injury of soft tissues according to claim 2, wherein the extract is prepared by the following method: weighing caulis et folium Mucunae Hederae, herba Lysimachiae Foenumgraeci, Notoginseng radix, radix Angelicae sinensis, Saviae Miltiorrhizae radix, and Carthami flos according to a certain proportion, mincing the whole formula, adding into 60-80 vol% ethanol 2-4 times of the total weight of each medicinal material, soaking for 10-30 days, filtering, and collecting the extractive solution.
4. A pharmaceutical preparation for external use comprising the extract of the Chinese medicinal composition for treating blunt soft tissue injury of claim 2 or 3 as an active ingredient.
5. The topical pharmaceutical formulation of claim 4, wherein the topical pharmaceutical formulation is one of a spray, an ointment, a gel, a liniment, a paste, or a patch.
6. Use of the Chinese medicinal composition for treating blunt injury of soft tissue according to claim 1 or an extract of the Chinese medicinal composition for treating blunt injury of soft tissue according to claim 2 or 3 in the preparation of a medicament for treating blunt injury of soft tissue.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105687586A (en) * | 2016-01-19 | 2016-06-22 | 佐今明制药股份有限公司 | Medicine for stopping bleeding of acute soft-tissue injury and wound |
| CN106581235A (en) * | 2016-12-21 | 2017-04-26 | 四川何天祺医院管理有限公司 | Pharmaceutical composition for treatment of soft tissue injuries |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104815112A (en) * | 2015-04-10 | 2015-08-05 | 栾尊一 | Traditional Chinese medicine composition for treating soft tissue injury and joint sprains |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105687586A (en) * | 2016-01-19 | 2016-06-22 | 佐今明制药股份有限公司 | Medicine for stopping bleeding of acute soft-tissue injury and wound |
| CN106581235A (en) * | 2016-12-21 | 2017-04-26 | 四川何天祺医院管理有限公司 | Pharmaceutical composition for treatment of soft tissue injuries |
Non-Patent Citations (2)
| Title |
|---|
| 跌打促愈片的质量标准研究;管燕等;《医药导报》;20060930;第25卷(第09期);960-962 * |
| 速效止痛酊治疗软组织损伤794例临床观察;李丽等;《长春中医学院学报》;19970930;第13卷(第03期);39-40 * |
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