CN114732850A - Plaster for rheumatism - Google Patents

Plaster for rheumatism Download PDF

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Publication number
CN114732850A
CN114732850A CN202210523088.XA CN202210523088A CN114732850A CN 114732850 A CN114732850 A CN 114732850A CN 202210523088 A CN202210523088 A CN 202210523088A CN 114732850 A CN114732850 A CN 114732850A
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parts
plaster
root
layer
rheumatism
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彭新国
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Sichuan Guohua Kangren Pharmaceutical Co ltd
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Sichuan Guohua Kangren Pharmaceutical Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237Notopterygium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/58Reptiles
    • A61K35/583Snakes; Lizards, e.g. chameleons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/62Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238Saposhnikovia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/27Asclepiadaceae (Milkweed family), e.g. hoya
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/486Millettia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention discloses a plaster for rheumatism, which is prepared from the following raw materials in parts by weight: 30-35 parts of vegetable oil, 80-90 parts of rosin, 30-40 parts of notopterygium root, 40-50 parts of medicinal cyathula root, 60-70 parts of raw kusnezoff monkshood root, 6-9 parts of borneol, 10-13 parts of earthworm, 14-18 parts of suberect spatholobus stem, 6-10 parts of divaricate saposhnikovia root, 2-8 parts of garter snake, 10-20 parts of Chinese angelica, 16-20 parts of paniculate swallowwort root, 10-15 parts of erythrina bark and 13-20 parts of rhizoma atractylodis; the plaster related by the invention is fast to be absorbed by human body; the traditional Chinese medicine has quick response and short treatment course for rheumatism and hyperosteogeny; the plaster has good air permeability, is friendly to skin, and can not generate the conditions of pruritus and skin ulceration; the plaster contains no lead, is mild and non-irritating to skin, can be continuously used, is environment-friendly and human-friendly in preparation process, and ensures the biological activity of the traditional Chinese medicine raw materials.

Description

Plaster for rheumatism
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a plaster for rheumatism.
Background
The rheumatism bone disease is called as rheumatic fever, rheumatic arthritis, rheumatoid arthritis, lumbar disc herniation, hyperosteogeny and other symptoms in western medicine, takes arthralgia, soreness, numbness, limited movement, stiffness and deformation as main clinical manifestations, severe bedridden patients have difficulty in pain and self-care of life. The Chinese medical science considers that the disease belongs to the scope of arthralgia. The factors inducing the disease are that the liver, spleen and kidney of a human body are deficient in essence and blood, muscles and bones are not nourished, and wind, cold, dampness and heat in the nature invade the human body and enter joints, so that qi and blood are blocked, qi and blood circulation is not smooth, and meridians are not smooth or phlegm and blood stasis are caused. Or the symptoms of joint pain, numbness of limbs, joint stiffness, body bending difficulty and the like caused by blood stasis stagnation and meridian obstruction due to overstrain and ease trauma.
The hyperosteogeny is the most common joint diseases which mainly take damage of joint cartilage and peripheral hyperosteogeny and involve tissues around the whole joint, the joint cartilage can degenerate, break and damage, even damage of the whole joint surface, the joint pain, stiffness, hypertrophy and limited movement are shown, the joint is better developed in load-bearing joints of knee, hip, cervical vertebra, lumbar vertebra and the like, and along with popularization of electrical appliances, the patients with cervical spondylosis and lumbar vertebra diseases are greatly increased due to increase of left time and reduction of outdoor movement.
In the prior art, aiming at the treatment of rheumatism and hyperosteogeny, western medicine treatment is usually performed by methods of diminishing inflammation, relieving pain, hormones, blocking, ultraviolet irradiation, traction, surgery and the like. Its disadvantages are temporary and permanent cure, long treatment time, poor curative effect, high cost and very high risk of operation. The traditional Chinese medicine treatment mostly adopts oral traditional Chinese medicines, adopts methods of relaxing tendons and activating collaterals, promoting blood circulation and removing blood stasis and the like, and has unobvious effect, or no effect after the initial taking, non-lasting curative effect and high recurrence rate. Moreover, the oral administration of traditional Chinese medicines is inconvenient, and some traditional Chinese medicines can stimulate the stomach, thereby causing adverse side effects.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide the plaster for treating rheumatism, which has the advantages of quick absorption, quick response, short treatment course, good air permeability and no lead.
The purpose of the invention is realized by the following technical scheme: a plaster for rheumatism comprises a self-heating layer, wherein a non-woven fabric layer is connected to the upper surface of the self-heating layer; the upper surface of the non-woven fabric layer is provided with a plaster layer, and the periphery of the plaster layer is provided with an adhesive layer; the adhesive layer is fixedly connected with the non-woven fabric layer; an ointment protective layer is arranged on the surface of the ointment layer; an outer protective layer is arranged above the ointment protective layer, and the edge of the outer protective layer is fixedly connected with the edge of the adhesive layer; the ointment layer and the ointment protective layer are provided with a plurality of micropores in a penetrating manner, the upper ends of the micropores are abutted against the outer protective layer, and the lower ends of the micropores are abutted against the non-woven fabric layer; the micropores are round holes and are arranged at equal intervals in a matrix manner; the plaster is in the shape of clover.
The self-heating layer of the plaster automatically generates heat when a patient uses the plaster, and promotes the absorption of the plaster by the human body; the ointment layer and the ointment protective layer are provided with a plurality of micropores in a penetrating way, so that the air permeability is good when the plaster is applied, and the situation that the skin is itchy and even ulcerated is prevented; the adhesive layer uses medical pressure-sensitive adhesive, has no side effect on human body, and has no toxicity or irritation on skin; the plaster is in a clover shape, so that when the use part of a patient is a part which is difficult to be attached, such as knee joint, shoulder and the like, the plaster can be tightly attached to the use part of the patient, and the use effect is ensured; the plaster is convenient to use, and the outer protective layer is torn off to be directly pasted on the affected part.
A plaster for rheumatism is prepared by processing the following raw materials in parts by weight: 30-35 parts of vegetable oil, 80-90 parts of rosin, 30-40 parts of notopterygium root, 40-50 parts of medicinal cyathula root, 60-70 parts of raw kusnezoff monkshood root, 6-9 parts of borneol, 10-13 parts of earthworm, 14-18 parts of suberect spatholobus stem, 6-10 parts of divaricate saposhnikovia root, 2-8 parts of garter snake, 10-20 parts of Chinese angelica, 16-20 parts of paniculate swallowwort root, 10-15 parts of erythrina indica lam and 13-20 parts of rhizoma atractylodis.
Square solution:
notopterygium root: exterior cold is dissipated; dispelling wind-damp; benefiting joints; relieving pain; wind-cold affecting the exterior; headache without sweating; oily mark, cold-dampness arthralgia; edema due to wind and water; sores and ulcers with pyogenic infections.
Radix cyathulae: removing blood stasis, dredging channels, promoting joint movement, and inducing diuresis for treating stranguria; it can be used for treating amenorrhea, abdominal mass, retained afterbirth, traumatic injury, rheumatalgia, flaccidity of feet, spasm of tendons, hematuria, and stranguria with blood.
Raw kusnezoff monkshood root: dispel wind and remove dampness, warm meridians and alleviate pain. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, cold hernia, and pain due to anesthesia.
Borneol: clear heat and dredge orifices, relieve swelling and alleviate pain.
Earthworm: clearing away heat, calming liver, relieving asthma (dyspnea), and dredging meridians. Can be used for treating hyperpyrexia, mania, convulsion, headache due to wind-heat, conjunctival congestion, and hemiplegia.
Caulis spatholobi: has effects in promoting blood circulation, relaxing muscles and tendons, nourishing blood, and regulating menstruation; can be used for treating waist and knee joint pain, rheumatalgia, numbness of limbs, quadriplegia, menoxenia, dysmenorrhea, amenorrhea, and leukopenia.
Wind prevention: dispelling pathogenic wind, relieving exterior syndrome, eliminating dampness, relieving pain, and relieving spasm; can be used for treating exterior syndrome due to exogenous pathogenic factor, rubella pruritus, rheumatalgia, tetanus, and spleen deficiency with excessive dampness.
Black-snake: dispelling wind-damp, dredging channels and collaterals; it is used to treat intractable rheumatism, skin numbness, bone and joint tuberculosis, rubella, scabies, leprosy, tetanus, and poliomyelitis.
Chinese angelica: regulating menstruation, promoting blood circulation, relieving inflammation and relieving pain.
Paniculate swallowwort root: has good effects of dispelling wind and relieving pain, and can be widely used for treating various pains caused by rheumatism, congealing cold, qi stagnation and blood stasis.
Sea tung bark: has effects of relieving pain, diminishing inflammation, dispelling pathogenic wind, activating qi-flowing, eliminating dampness and promoting blood circulation, and can be used for treating gastritis, nephritis and rheumatalgia by treating root bark, and also can be used for external application on incised wound.
Rhizoma atractylodis: eliminating dampness and strengthening spleen; dispelling wind-damp; improving eyesight; dampness affecting the spleen and stomach; lassitude for sleeping; distention and fullness in the abdomen; loss of appetite; vomiting and diarrhea; phlegm-fluid retention; edema due to dampness; dampness of exterior syndrome and exterior syndrome; heavy and painful head and body; arthralgia syndrome; aching and painful extremities; atrophy of the cutis and the plica; night blindness.
The vegetable oil and the rosin are excipients; the basic formula of the traditional Chinese medicine formula comprises notopterygium root, radix cyathulae and raw kusnezoff monkshood root, so that the traditional Chinese medicine formula has good effects on some symptoms caused by rheumatism and hyperosteogeny, and the borneol reduces the irritation of the plaster and can reduce swelling and relieve pain; many rheumatism causes respiratory abnormality in the late stage, and the earthworm treats the respiratory abnormality; the later stage of rheumatism also causes leucopenia, and the caulis spatholobi is effective in preventing leucopenia; rheumatism is manifested on the skin to cause rash, and the divaricate saposhnikovia root and the garter snake are used for treating the rash while expelling the rheumatism; rheumatism can cause various pain symptoms, and the angelica, the paniculate swallowwort root and the erythrina bark all have analgesic effect; rheumatism also affects the gastrointestinal system, and the rhizoma atractylodis dispels rheumatism and simultaneously exerts the effect on distension and fullness of the abdomen; it can be used for treating anorexia and invigorating spleen; the plaster prepared by the raw materials has the advantages of quick response, good curative effect, no side effect, no pollution in the preparation process and environmental and human body friendliness to patients with rheumatism and hyperosteogeny under the synergistic effect of various traditional Chinese medicinal materials.
A preparation method of a plaster for rheumatism comprises:
s1: weighing 30-40 parts of notopterygium root, 40-50 parts of medicinal cyathula root, 60-70 parts of raw kusnezoff monkshood root, 6-9 parts of borneol, 10-13 parts of earthworm, 14-18 parts of suberect spatholobus stem, 6-10 parts of divaricate saposhnikovia root, 2-8 parts of garter snake, 10-20 parts of Chinese angelica, 16-20 parts of paniculate swallowwort root, 10-15 parts of erythrina indica lam bark and 13-20 parts of rhizoma atractylodis, and grinding into powder to obtain traditional Chinese medicine powder;
s2: adding ethanol into the Chinese medicinal powder, soaking for 1-2 days, and heating to extract medicinal liquid to obtain plaster medicinal liquid;
s3: grinding rosin, putting the ground rosin and vegetable oil into a container, heating to melt the rosin, and keeping the temperature at 60-100 ℃;
s4: and mixing the plaster liquid medicine into a container, stirring, and concentrating to obtain the paste plaster.
Compared with the traditional plaster preparation method, the plaster does not generate lead compound gas in the preparation process, is harmless to the environment and human body, and the prepared plaster does not contain lead agent, has no stimulation to skin, can be continuously used and has no adverse reaction; and the temperature is lower during processing, so that the biological activity of the traditional Chinese medicine raw materials can be ensured, and the curative effect of the traditional Chinese medicine raw materials is not influenced.
The invention has the beneficial effects that: the plaster related by the invention is fast to be absorbed by human body; the traditional Chinese medicine has quick response and short treatment course for rheumatism and hyperosteogeny; the plaster has good air permeability, is friendly to skin, and can not generate the conditions of pruritus and skin ulceration; the plaster does not contain lead, is mild and non-irritating to skin, can be continuously used, is environment-friendly and human-friendly in the preparation process, and ensures the biological activity of the traditional Chinese medicine raw materials.
Drawings
FIG. 1 is a schematic view of the structure of a plaster;
FIG. 2 is a top view of the plaster;
1-self-heating layer, 2-non-woven fabric layer, 3-adhesive layer, 4-ointment layer, 5-ointment protective layer, 6-micropore and 7-outer protective layer.
Detailed Description
The technical solutions of the present invention are further described in detail below with reference to the accompanying drawings, but the scope of the present invention is not limited to the following.
A plaster for rheumatism comprises a self-heating layer 1, wherein a non-woven fabric layer 2 is connected to the upper surface of the self-heating layer 1; the upper surface of the non-woven fabric layer 2 is provided with a plaster layer, and the periphery of the plaster layer is provided with an adhesive layer 3; the adhesive layer 3 is fixedly connected with the non-woven fabric layer 2; an ointment protective layer 5 is arranged on the surface of the ointment layer; an outer protective layer 7 is arranged above the ointment protective layer 5, and the edge of the outer protective layer 7 is fixedly connected with the edge of the adhesive layer 3; the plaster layer 4 and the plaster protective layer 5 are provided with a plurality of micropores 6 in a penetrating way; the micropores are round holes 6 and are arranged at equal intervals in a matrix manner; the ointment layer 4 is in the shape of clover.
Example 1:
weighing the following raw materials in proportion:
30 parts of vegetable oil, 80 parts of rosin, 30 parts of notopterygium root, 40 parts of medicinal cyathula root, 60 parts of raw kusnezoff monkshood root, 6 parts of borneol, 10 parts of earthworm, 14 parts of suberect spatholobus stem, 6 parts of divaricate saposhnikovia root, 2 parts of garter snake, 10 parts of Chinese angelica, 16-20 parts of paniculate swallowwort root, 10 parts of erythrina bark and 13 parts of swordlike atractylodes rhizome.
Example 2:
weighing the following raw materials in proportion:
33 parts of vegetable oil, 86 parts of rosin, 33 parts of notopterygium root, 47 parts of medicinal cyathula root, 63 parts of raw kusnezoff monkshood root, 7 parts of borneol, 12 parts of earthworm, 16 parts of suberect spatholobus stem, 8 parts of divaricate saposhnikovia root, 5 parts of garter snake, 15 parts of Chinese angelica, 18 parts of paniculate swallowwort root, 13 parts of erythrina bark and 17 parts of rhizoma atractylodis.
Example 3:
weighing the following raw materials in proportion:
35 parts of vegetable oil, 90 parts of rosin, 40 parts of notopterygium root, 50 parts of medicinal cyathula root, 70 parts of raw kusnezoff monkshood root, 9 parts of borneol, 13 parts of earthworm, 18 parts of suberect spatholobus stem, 10 parts of divaricate saposhnikovia root, 8 parts of garter snake, 20 parts of Chinese angelica, 20 parts of paniculate swallowwort root, 15 parts of erythrina bark and 20 parts of rhizoma atractylodis.
The preparation method of the ointment comprises the following steps:
s1: weighing borneol, saffron crocus, keel, myrrh, notopterygium root, eucommia bark, medicinal cyathula root, earthworm, suberect spatholobus stem, raw kusnezoff monkshood root, dragon's blood, fourstamen stephania root, divaricate saposhnikovia root, tall gastrodia tuber, Chinese angelica, large-leaved gentian, paniculate swallowwort root, kelp, erythrina bark, garden balsam stem, garter snake part and rhizoma atractylodis, grinding into powder to obtain traditional Chinese medicine powder;
s2: adding ethanol into the Chinese medicinal powder, soaking for 1 day, and heating to obtain medicinal liquid to obtain plaster medicinal liquid;
s3: grinding rosin, putting the ground rosin and vegetable oil into a container, heating to melt the rosin, and keeping the temperature at 85 ℃;
s4: and mixing the plaster liquid medicine into a container, stirring, and concentrating to obtain the paste plaster.
The prepared plaster was spread on a non-woven fabric layer in an amount of 15g in a clover shape, and a finished plaster was prepared in accordance with the designed plaster structure to obtain a plaster prepared in the corresponding example.
Comparative example:
selecting 40 patients suffering from rheumatism and 40 patients suffering from hyperosteogeny, and recording the alleviation and healing time of relevant symptoms by using the existing plaster (collateral-dredging and pain-relieving plaster) aiming at the rheumatism and the hyperosteogeny, wherein the recorded data are shown in tables 1 and 2.
Example 4:
selecting 120 patients suffering from rheumatism and 120 patients suffering from hyperosteogeny with symptoms and medical history similar to those of the comparative example; the plasters prepared in example 1, example 2 and example 3 were used in 3 groups, respectively, and the alleviation of the associated symptoms and the recovery time were recorded, and the recorded data are shown in table 1 and table 2.
Table 1: record table for improving disease condition
Figure BDA0003642714090000051
Figure BDA0003642714090000061
Table 2: side effect record table
Figure BDA0003642714090000062
As shown in Table 1, compared with the existing plaster for treating rheumatism and hyperosteogeny in the market, the plaster prepared by the invention has the advantages of quicker response to the rheumatism and the hyperosteogeny, higher recovery ratio of patients and no side effect basically.
Typical clinical cases:
case 1, lie in a certain, male, 49 years old, chengning city people, knee joint hyperosteogeny, pain, difficulty in walking and no work, and the plaster prepared by the formula of the embodiment 1 of the invention is used for treating 3 courses of treatment and can be cured.
In case 2, a king woman, 58 years old, le zhi county, suffered from lumbar hyperosteogeny for 3 years, could not walk and could not do everything before doing the housework, and the plaster prepared by the formula of the embodiment 3 of the invention is cured in 4 courses of treatment.
Case 3, Liu lady, 59 years old, south peace cleaner, suffered from lumbar hyperosteogeny for 2 years, and had gone to the large and small hospitals for treatment without cure, the plaster prepared by using the formula of the embodiment 2 of the invention was used for treatment for 2 courses of treatment and the recovery was achieved.
In case 4, women who are healthy, are 68 years old, and people in Anyang city suffer from lumbar disc herniation, press nerves, pain and numbness of lower limbs, cannot walk, and do not cure when seeking medical help from many parties, and the plaster prepared by the formula of the embodiment 3 of the invention is used for treating 6 courses of treatment.
In case 5, mr. zhangyang, 45 years old, the education worker seniorized the knee joint for 3 years and could not walk, the plaster prepared by the formula of the embodiment 2 of the invention can be used for treatment for 2 courses of treatment, and the life is recovered to normal.
In case 6, a woman is 45 years old, and the sanitation worker cannot work after suffering from knee joint hyperplasia for 3 years, the plaster prepared by the formula of the embodiment 3 of the invention is used for treating 3 courses of treatment, and the life is recovered.
Patient 7, mr. populus, 47 years old, adult urban people with cervical hyperplasia for 7 years, the disease is long due to fishing, and the patients feel headache, insomnia and vexation, feel numb fingers and back are sunken and tired, and lose labor force. The plaster prepared by the formula of the embodiment 3 of the invention can be cured in 2 months, and all heavy physical labor can be involved.
In case 8, a grandchild, 60 years old, a person in TUNNING City, who was tired, was dizzy in the morning and could not get up, was examined by CT in hospital to be hyperosteogeny of cervical vertebra, and was discharged from hospital two days in the near-year-round, the plaster prepared by the formulation of the invention in example 1 was pasted, no dizziness occurred after three days, and the patient went on the ground after five days, and 7 plasters were used for curing and no recurrence occurred.
In case of 9 cases, mr. high, 55 years old, constructors in Jianyang city, with swelling and pain in both knees, difficulty in walking, and diagnosis of rheumatoid arthritis for 8 years, doctors recommend surgical treatment, namely, surgical excision of the massive smooth muscle of knee joint, and the plaster prepared by the formulation of embodiment 3 of the invention is used for 4 treatment courses to cure the arthritis.
In case 10, a king woman, 61 years old, Pengyun county, with swelling and pain in both knees, who is difficult to walk, was diagnosed as rheumatoid arthritis by multiple hospitals, the patient used the plaster prepared according to the formulation of example 1 of the present invention, and the patient was automatically retested after three days, the pain symptom was significantly relieved, the patient had significantly improved his/her own movement before the movement, and the patient continued to use the plaster, had no pain after 20 days, had normal movement, and was fully cured.
Case 11, mr. forestry, 29 years old, qixingcun people in buxi county, town, 10 months No. 1, first visit 2019, chief complaints: the pain of the double knees, cold water can not be used in summer, the condition of the disease becomes worse in rainy days, the diagnosis is performed by using the acupuncture and massage physical therapy effect which is not good, the patient is subjected to the follow-up diagnosis after twice use of the plaster prepared by the formula of the embodiment 1 of the invention, the pain symptom of the double knees of the patient is obviously improved, the medicine is continuously used, the patient is diagnosed after one month, the self-describing symptom disappears, and the patient is cured.
Case 12, liu lady, 36 years old, feixi county, buxu town, qixingcun, 9 month, 3, 2019, the first visit, chief complaints: in addition, the rheumatic arthritis is treated by adopting methods of plaster, massage and the like, the effect is poor, 3 parts of plaster prepared by using the formula of the embodiment 2 are given, the patient comes for a double-diagnosis after 10 days, the self-describing symptoms are obviously relieved, and the symptoms completely disappear and are healed after the patient continues to use the plaster for 35 days.
Case 13, rush female, age 64, westernly filled, first visit No. 6/23 in 2020, complaining: pain in the right shoulder joint is more than three years, right shoulder lifting is limited, and No. 3 and 28 in 2018 is reported in right shoulder joint shooting in Zhen health college: the bone of the right shoulder joint has no obvious abnormality, and the rheumatic scapulohumeral periarthritis is considered, so that the doctor is asked for a plurality of places and the patient is not treated with the disease. After the plaster prepared by the formula of the embodiment 2 of the invention is used for the treatment for the follow-up examination after 5 days, the self-describing symptoms of the patient are relieved, the patient continues to take the plaster for the follow-up examination after one treatment course, the symptoms of the patient basically disappear, the patient is respected of the suggestion of the patient, the plaster is taken for 20 days, the symptoms of the patient disappear, and the right shoulder moves as usual, so the patient is cured.
The foregoing is illustrative of the preferred embodiments of the present invention, and it is to be understood that the invention is not limited to the precise form disclosed herein and is not to be construed as limited to the exclusion of other embodiments, and that various other combinations, modifications, and environments may be used and modifications may be made within the scope of the concepts described herein, either by the above teachings or the skill or knowledge of the relevant art. And that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (8)

1. The plaster for rheumatism is characterized by comprising, by weight, 30-35 parts of vegetable oil, 80-90 parts of rosin, 30-40 parts of notopterygium root, 40-50 parts of medicinal cyathula root, 60-70 parts of raw kusnezoff monkshood root, 6-9 parts of borneol, 10-13 parts of earthworm, 14-18 parts of suberect spatholobus stem, 6-10 parts of divaricate saposhnikovia root, 2-8 parts of garter snake, 10-20 parts of Chinese angelica, 16-20 parts of paniculate swallowwort root, 10-15 parts of erythrina bark and 13-20 parts of rhizoma atractylodis.
2. A plaster patch for rheumatism is characterized in that: the self-heating layer comprises a self-heating layer (1), wherein the upper surface of the self-heating layer (1) is connected with a non-woven fabric layer (2); the upper surface of the non-woven fabric layer (2) is provided with a plaster layer, and the periphery of the plaster layer is provided with an adhesive layer (3); the adhesive layer (3) is fixedly connected with the non-woven fabric layer (2); an ointment protective layer (5) is arranged on the surface of the ointment layer; an outer protection layer (7) is arranged above the ointment protection layer (5), and the edge of the outer protection layer (7) is fixedly connected with the edge of the adhesive layer (3).
3. The plaster for rheumatism according to claim 2, wherein: the ointment layer (4) and the ointment protective layer (5) penetrate through a plurality of micropores (6), the upper ends of the micropores (6) are abutted to the outer protective layer (7), and the lower ends of the micropores are abutted to the non-woven fabric layer (2).
4. The plaster for rheumatism according to claim 3, wherein: the micropores are round holes (6) which are arranged at equal intervals in a matrix manner.
5. The plaster for rheumatism according to claim 2, wherein: the plaster is in the shape of clover.
6. A plaster for rheumatism according to claim 1, which is prepared by a method comprising:
s1: weighing 30-40 parts of notopterygium root, 40-50 parts of medicinal cyathula root, 60-70 parts of raw kusnezoff monkshood root, 6-9 parts of borneol, 10-13 parts of earthworm, 14-18 parts of suberect spatholobus stem, 6-10 parts of divaricate saposhnikovia root, 2-8 parts of garter snake, 10-20 parts of Chinese angelica, 16-20 parts of paniculate swallowwort root, 10-15 parts of erythrina indica lam bark and 13-20 parts of rhizoma atractylodis, and grinding into powder to obtain traditional Chinese medicine powder;
s2: adding ethanol into the Chinese medicinal powder, soaking, and heating to extract medicinal liquid to obtain plaster medicinal liquid;
s3: grinding rosin, and putting the ground rosin and vegetable oil into a container to be heated so as to melt the rosin;
s4: and mixing the plaster liquid medicine into a container, stirring, and concentrating to obtain the paste plaster.
7. The plaster for rheumatism according to claim 5, wherein: the ethanol soaking time in the step S2 is 1-2 days.
8. The plaster for rheumatism according to claim 5, wherein: in step S3, the heating temperature is 60-100 ℃.
CN202210523088.XA 2022-05-05 2022-05-13 Plaster for rheumatism Pending CN114732850A (en)

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