CN111529584A - A Chinese medicinal composition for treating fracture, arthritis and acute and chronic soft tissue injury, and its preparation method - Google Patents

Abstract

The invention discloses a Chinese medicinal composition for treating fracture, arthritis and acute and chronic soft tissue injury and a preparation method thereof, and is characterized in that the Chinese medicinal composition comprises effective components and auxiliary materials, wherein the effective components comprise: 10-50g of dipsacus asperoides, 10-50g of drynaria rhizome, 10-50g of radix angelicae batryae, 5-40g of garden balsam stem, 5-30g of frankincense, 5-40g of myrrh, 10-50g of native copper, 5-40g of medicinal cyathula root, 5-30g of ground beetle, 5-40g of angelica, 5-40g of safflower, 10-55g of keel and 600g of honey 400-. The Chinese medicinal composition can directly act on an affected part, increase the local blood flow speed and the vascular permeability, dilate blood vessels around a focus, accelerate blood flow, promote the infiltration and absorption of effective components of the medicament, promote the absorption of inflammation and the regression of swelling, accelerate the local blood circulation, shorten the treatment time and promote the quick recovery of fracture.

Description

A Chinese medicinal composition for treating fracture, arthritis and acute and chronic soft tissue injury, and its preparation method

Technical Field

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating fracture, arthritis and acute and chronic soft tissue injury and a preparation method thereof.

Background

Fracture is a common clinical orthopedic disease, and refers to the condition that the bone structure is completely or partially broken continuously. The causes of fractures are mainly related to direct or indirect violence, long-term or repeated injury and other factors. In recent years, the incidence of fracture in China is gradually increased, and clinical symptoms of patients after fracture are mainly manifested as limited movement, deformity, grating bone and the like. Fracture can seriously damage the motor function of a patient, so that the life quality of the patient is linearly reduced, and the patient needs to be treated in time.

At present, the main clinical treatment means for fracture include operations, plaster fixation, brace fixation and the like.

After fracture, local tissues can be seriously damaged, pain and swelling occur, and local bleeding occurs, the operation is a wound, the pain and swelling are easily aggravated, adverse effects are caused on wound healing of a patient, nerve damage, blood vessel damage, venous reflux obstruction and the like are easily caused by poor treatment, the injured parts are accompanied with the pain and swelling for a long time, even osteofascial compartment syndrome is caused, wound healing is delayed, and postoperative rehabilitation and life quality of the patient are seriously affected; and the operation treatment fracture aggravates the time of the patient lying in bed, the treatment period, the cost is high, and some operations even need to be repeated for a plurality of times, thereby bringing the patient with the double-body fracture.

The plaster and the brace are adopted for fixing and treating the fracture, the venous and lymphatic return is blocked due to long-time fixation, the phenomena of muscular atrophy, blood vessel nerve regulation dysfunction and the like are caused, the function of a deep venous valve of the lower limb is reduced, the tissue edema is caused, the delay rehabilitation is mainly treated clinically by adopting conventional means of diminishing inflammation, relieving pain, stopping bleeding and the like at present, and the aim is to promote the rapid healing of the fracture, but the effect is poor.

In clinic, although the patient is treated by western medicine timely and effectively, the best rehabilitation therapy opportunity is missed due to swelling, pain and the like. The traditional Chinese medicine has certain help in relieving fracture pain and swelling, provides good conditions for carrying out rehabilitation treatment as early as possible, and is beneficial to fracture healing. The healing and blood circulation promoting decoction is used for treating the initial stage of fracture, and aims to relieve pain, accelerate the subsidence of swelling, promote the blood circulation around the fracture and create good conditions for the early development of rehabilitation training.

The traditional Chinese medicine has great advantages in the aspect of preventing and treating osteoarthritis, and the traditional Chinese medicine theory holds that meridians and collaterals are damaged after the body is fractured, so that nutrient blood is separated from meridians and collaterals, the veins are blocked, and the nutrient blood is accumulated in skin striae, and further swelling is caused. The blood stasis of the meridians and qi stagnation can lead to venous obstruction and pain, which can cause swelling and pain. Therefore, the treatment principle is that the swelling and pain can be relieved, the blood circulation can be promoted, the blood stasis can be removed, and the nutrient-blood can be separated from the meridians and can be blocked and accumulated in the skin striae, thereby causing the swelling. The blood stasis of the meridians and qi stagnation can lead to venous obstruction and pain, which can cause swelling and pain. Therefore, the treatment principle is mainly to relieve swelling and pain, activate blood and resolve stasis, and clear and activate the channels and collaterals. The stasis can not be removed when blood is not alive, the bone can not be connected when the blood stasis is not removed, the traditional Chinese medicine for reuniting the bones and the tendons has the functions of promoting the absorption of the blood stasis, the swelling subsides, the circulation of qi and blood and accelerating the growth of callus, the external application traditional Chinese medicine has higher application value in the treatment of fracture patients, the external application traditional Chinese medicine can directly act on the affected part by contacting the affected part, thereby increasing the speed of local blood flow and the permeability of blood vessels, expanding the blood vessels around the focus, accelerating the blood flow, simultaneously promoting the infiltration and absorption of effective components of the medicine, promoting the absorption of inflammation and the subsidence of the swelling, accelerating the local blood circulation, shortening the treatment time, promoting the quick recovery of the fracture, improving the.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating fracture, arthritis and acute and chronic soft tissue injuries and a preparation method thereof.

In order to achieve the purpose, the technical scheme adopted by the invention comprises the following steps:

a Chinese medicinal composition for treating fracture, arthritis and acute and chronic soft tissue injury is characterized by comprising effective components and auxiliary materials, wherein the effective components are as follows: 10-50g of dipsacus asperoides, 10-50g of drynaria rhizome, 10-50g of radix angelicae batryae, 5-40g of garden balsam stem, 5-30g of frankincense, 5-40g of myrrh, 10-50g of native copper, 5-40g of medicinal cyathula root, 5-30g of ground beetle, 5-40g of angelica, 5-40g of safflower, 10-55g of keel and 600g of honey 400-.

More preferably, the effective components also comprise 5-40g of rhubarb and 5-25g of mirabilite.

Preferably, the effective components also comprise 5-30g of cuttlebone and 10-40g of chicken's gizzard-membrane.

Further preferably, the effective components in the traditional Chinese medicine composition are as follows: 15-45g of dipsacus asperoides, 15-45g of drynaria rhizome, 15-50g of radix angelicae gigantis, 10-30g of garden balsam stem, 10-30g of frankincense, 10-35g of myrrh, 10-40g of native copper, 5-30g of medicinal cyathula root, 5-30g of ground beetle, 5-40g of angelica, 5-40g of safflower, 10-50g of dragon bone, 5-40g of rhubarb, 5-25g of mirabilite, 10-30g of cuttlebone, 10-40g of chicken's gizzard-membrane and 600g of honey 400.

Further preferably, the effective components in the traditional Chinese medicine composition are as follows: 15-45g of dipsacus asperoides, 15-45g of drynaria rhizome, 15-50g of radix angelicae gigantis, 10-30g of garden balsam stem, 10-30g of frankincense, 10-30g of myrrh, 20-40g of native copper, 10-30g of medicinal cyathula root, 10-30g of ground beetle, 10-30g of angelica, 5-40g of safflower, 22-46g of dragon bone, 10-25g of rhubarb, 10-20g of mirabilite, 20-30g of cuttlebone, 20-30g of endothelium corneum gigeriae galli and 500g of honey.

Further preferably, the effective components in the traditional Chinese medicine composition are as follows: 30g of dipsacus asperoides, 30g of drynaria rhizome, 30g of radix baji, 20g of garden balsam stem, 20g of frankincense, 20g of myrrh, 30g of native copper, 20g of medicinal cyathula root, 20g of ground beetle, 20g of angelica, 20g of safflower, 36g of dragon bone, 20g of rhubarb, 15g of mirabilite, 20g of cuttlebone, 30g of endothelium corneum gigeriae galli and 500g of honey.

Furthermore, the traditional Chinese medicine composition is added with pharmaceutical auxiliary materials commonly used in pharmaceutics to prepare an external patch.

The invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating fracture, arthritis and acute and chronic soft tissue injury, which is characterized by comprising the following steps:

[1] respectively drying and crushing the raw material medicines, and sieving the raw material medicines by a 100-mesh sieve for later use;

[2] mixing 500kg of honey with 80ml of azone, adding the medicinal powder prepared in the step, fully stirring and uniformly mixing to prepare paste, coating the paste on auxiliary materials, and adding the paste to a non-woven fabric adhesive plaster to obtain the honey-fried glutinous rice flour.

Furthermore, the invention also aims to protect the application of the traditional Chinese medicine composition in preparing medicines for treating fracture, arthritis, acute and chronic soft tissue injury and the like.

The traditional Chinese medicine comprises the following traditional Chinese medicinal materials in the formula:

keel: sweet, astringent and slightly cold; the functional indications are as follows: calming the liver and suppressing yang, tranquilizing and allaying excitement, astringing and arresting discharge, yin deficiency and yang hyperactivity, dysphoria and irascibility, dizziness, blurred vision, uneasiness, palpitation, insomnia, epilepsy, mania, spermatorrhea, leukorrhagia, sweating, metrorrhagia.

Rhubarb: bitter and cold; the functional indications are as follows: it has effects in clearing away heat and toxic materials, purging pathogenic accumulation, clearing away heat, purging pathogenic fire, promoting blood circulation, and dispelling blood stasis, and can be used for treating intestinal stagnation, constipation, hematemesis due to blood heat, epistaxis due to hemorrhage, conjunctival congestion, pharyngalgia, gingival swelling and pain, burn, female blood stasis, amenorrhea, puerperal lochiorrhea, scar accumulation, and traumatic injury.

Mirabilite: salty, bitter and cold; the functional indications are as follows: purgation, hardness softening and heat clearing, and can be used for treating excess heat accumulation, constipation, pharyngalgia, aphtha, conjunctival congestion and pyocutaneous disease.

Cuttlebone: salty, astringent and slightly warm; the functional indications are as follows: metrorrhagia, metrostaxis, hemorrhage of lung and stomach, hemorrhage due to trauma, spermatorrhea, leukorrhagia, gastralgia, acid regurgitation, eczema, and ulcer with pus.

Endothelium corneum gigeriae galli: sweet and mild; the functional indications are as follows: activating spleen to promote digestion, and securing essence to stop enuresis, and originally used for treating dyspepsia, indigestion, cellulitis in the interior of children and the like.

Teasel root: bitter, sweet, pungent and slightly warm; the functional indications are as follows: tonify liver and kidney, promote blood circulation, reunite tendons and bones, and treat lumbago, leg weakness, spermatorrhea, metrorrhagia, traumatic injury, incised wound, carbuncle, ulcer.

Rhizoma drynariae: bitter and warm; the functional indications are as follows: invigorating kidney, promoting blood circulation, stopping bleeding, and healing wound, and can be used for treating lumbago due to kidney deficiency, foot weakness, tinnitus, deafness, toothache, chronic diarrhea, traumatic injury, contusion, and injury of bones and muscles.

Baji day: pungent, sweet and slightly cold; the functional indications are as follows: invigorating kidney, tonifying yang, dispelling pathogenic wind, removing dampness, and can be used for treating sexual impotence, frequent micturition, infertility due to cold womb, menoxenia, lower abdomen psychroalgia, lumbago, gonalgia, and weakness.

Garden balsam stem: pungent and warm; the functional indications are as follows: promoting blood circulation and relieving pain, and can be used for treating rheumatic arthritis, spasm of tendons and bones, eczema, pyocutaneous disease, toxic swelling, and numbness of limbs.

Frankincense: pungent, bitter and slightly warm; the functional indications are as follows: promoting blood circulation and activating qi-flowing, inducing menstruation to relieve pain, subsiding swelling and promoting granulation, relieving pain of heart and abdomen, rheumatalgia, amenorrhea and dysmenorrhea, traumatic injury and blood stasis and pain, superficial infection and toxic swelling, appendicitis, and unhealed sore and ulcer.

Myrrh: bitter and flat; the functional indications are as follows: promoting blood circulation, relieving pain, subsiding swelling, promoting granulation, blood stasis and pain in chest and abdomen, dysmenorrhea, amenorrhea, abdominal mass, traumatic injury, carbuncle, swelling, sore and ulcer, intestinal abscess, and conjunctival congestion with swelling and pain.

Native copper: pungent and mild; the functional indications are as follows: removing blood stasis, relieving pain, setting bone and healing wound, and can be used for treating traumatic injury, fracture, and swelling and pain due to blood stasis.

Radix cyathulae: bitter, sour and mild; the functional indications are as follows: promoting blood circulation, dispelling blood stasis, nourishing liver and kidney, strengthening tendons and bones, inducing diuresis, treating stranguria, and promoting blood circulation, and can be used for treating menoxenia due to blood stasis, dysmenorrhea, amenorrhea, puerperal abdominal pain due to blood stasis, traumatic injury, soreness of waist and knees, weakness of lower limbs, hematuria, dysuria, and urethral pain.

Ground beetle: salty, cold and slightly toxic; the functional indications are as follows: removing blood stasis, and promoting reunion of fractured tendons and bones, and can be used for treating amenorrhea, puerperal stagnation, abdominal mass, fracture injury, stagnation pain, and lumbar sprain.

Chinese angelica: sweet, pungent and warm, with the main functions: replenishing blood, promoting blood circulation, relieving pain, and moistening intestine, and can be used for treating blood deficiency syndrome, menoxenia, amenorrhea, dysmenorrhea, asthenia cold abdominal pain, blood stasis pain, traumatic injury, arthralgia, numbness, superficial infection, and pyocutaneous disease.

Safflower: pungent and warm; the functional indications are as follows: promoting blood circulation, dispelling blood stasis, dredging channels, promoting blood circulation, amenorrhea, puerperal stagnation, abdominal pain, abdominal mass, traumatic injury, blood stasis and pain, and arthralgia.

Honey: sweet and mild; the functional indications are as follows: lubricant and excipient, can be administered orally for invigorating middle warmer, relieving spasm, moistening lung, relieving cough, and relaxing bowels, and can be used as ointment and plaster matrix for external use.

The prescription is reasonable and innovative, radix cyathulae and teasel root in the prescription have obvious curative effects of tonifying liver and kidney and strengthening bones and muscles, especially in osteoporosis and fracture, the radix stemonae and the rhizoma drynariae can reunite bones and tendons, dissipate blood stasis and relieve pain, the broken bones can promote the absorption of the bones to calcium, the levels of blood calcium and blood phosphorus are improved, the fracture healing is facilitated, the garden balsam stems can relax tendons and activate collaterals, the frankincense and the myrrh can promote blood circulation and relieve pain, the blood viscosity can be reduced, the microcirculation is improved, the platelet aggregation and the thrombus formation are inhibited, the absorption and the blood circulation of blood stasis can be promoted, conditions are created for organism tissue repair, the safflower is used for removing blood stasis and relieving pain, the carthamin the safflower can effectively reduce the platelet aggregation and inhibit the formation, the angelica is used for promoting blood circulation and removing blood stasis, the platelet aggregation can be reduced, the immune function can also be adjusted, and the native copper.

Mirabilite is a crystal refined from natural minerals containing sodium sulfate, and has the main effects of purgation, hardness softening and heat clearing. The rhubarb has the main functions of purgation and accumulation elimination, heat clearing and fire purging, hemostasis, detoxification, blood circulation activation and blood stasis removal, and the mirabilite and the rhubarb are used together, so that the constipation is treated, the fat liquefaction, infection and hematoma of an incision in an abdominal operation can be prevented and treated, the healing time of the incision can be shortened, and the treatment effects mainly come from the anti-inflammation, swelling-diminishing and pain-relieving effects of the rhubarb and the mirabilite.

Cuttlebone, with the actions of relieving hyperacidity and pain, astringing and arresting seminal emission, blood and leucorrhea, is currently used in the treatment of various bleeding, gastroduodenal ulcer, chronic gastritis and other diseases. But the book of Yi Xue Zhong xi Lu considers that it has the functions of tonifying kidney meridian and assisting kidney to store, besides it is salty in taste and warm in nature, so Hai Piao Xiao can also warm and remove blood stasis and blood, and has mild potency of medicine, and can promote the formation of blood vessels at the fracture part to different degrees.

The endothelium corneum gigeriae galli has the effects of helping digestion and strengthening spleen, arresting seminal emission and arresting enuresis, treating stranguria and dissolving calculus and regulating blood rheology, is commonly used for diseases such as indigestion, infantile malnutrition, enuresis and nocturnal emission, stranguria with stone and relieving pain, and is considered by the records of Zhongzhong Zhongxi of medicine to eliminate accumulation of spleen and stomach and any accumulation syndrome, and blood stasis in blood vessels of muscles and bones is actually accumulation of blood stasis, and the endothelium gigeriae galli contains abundant gastric hormone, amylase, trace pepsin, keratin and various amino acids, and can permeate skin to promote healing of local damaged tissues when being externally used. Although the two medicines of the cuttlebone and the endothelium corneum gigeriae galli are both rarely applied to the fracture, the clinical practice proves that the cuttlebone is compatible with the endothelium corneum gigeriae galli, the two medicines take the effects of dispersing blood stasis together and have mild medicine properties, and the effect of treating the bone fracture disease is clear.

The honey is sweet and nontoxic, has the effects of tonifying qi and strengthening the middle-jiao, relieving pain and detoxifying, and removing diseases, and contains acidic substances and high-concentration carbohydrate substances, so that bacteria can hardly survive at wound parts, the infection caused by blood stasis is reduced, and the absorption caused by local blood stasis is facilitated. Meanwhile, the original pure honey contains biotin which plays a promoting role in organism generation, so the pure honey is selected as a substrate. The medicines are used together to play the functions of relieving swelling and pain, promoting reunion of fractured bones, and clearing and activating the channels and collaterals.

Compared with the prior art, the traditional Chinese medicine composition disclosed by the invention is reasonable and innovative in formula, has the effects of promoting blood circulation to remove blood stasis, relieving swelling and eliminating swelling, warming and activating meridians, strengthening muscles and bones, eliminating dampness and activating collaterals, and warming and relieving pain, can exert good effects of dredging meridians, activating blood circulation to remove blood stasis, accelerating the healing of fracture, promoting the subsidence of swelling, accelerating local blood circulation, and effectively avoiding the occurrence of complications such as joint stiffness, muscular atrophy and the like.

The traditional Chinese medicine composition can treat various arthritis, osteoarthropathy and gouty arthritis caused by wind-cold-dampness blocking channels and collaterals; muscle and bone pain, debilitation and cramp caused by chronic strain. The traditional Chinese medicine has mild nature and taste, does not cause obvious adverse reaction and toxic and side effect to patients, has low price, is easy to master a treatment method, does not cause great psychological pressure and economic burden to the patients, and has relatively high acceptance and tolerance of the patients.

Detailed Description

The present invention will be further described with reference to the following examples, but the present invention is not limited thereto.

The following is a pharmacodynamic study of the composition of the present invention, and in order to simplify the experimental operation and save the research cost, and follow the experimental principles of parallel control, thereby more scientifically highlighting the creativity of the technical solution of the present invention, we will typically perform a representative study on one technical solution group of the present invention, which can be fully deduced by those skilled in the art to understand the beneficial effects of other parameter point technical solutions in the present application, and therefore the technical content and the pharmacodynamic results of the present invention are by no means limited to this scope.

Application embodiment 1

1 test materials and results processing method:

1.1 preparation of the test drugs of the invention:

[1] the raw material medicaments in the following weight ratio are taken: 30g of dipsacus asperoides, 30g of drynaria rhizome, 30g of radix baji, 20g of garden balsam stem, 20g of frankincense, 20g of myrrh, 30g of native copper, 20g of medicinal cyathula root, 20g of ground beetle, 20g of angelica, 20g of safflower, 36g of dragon bone, 20g of rhubarb, 15g of mirabilite, 20g of cuttlebone and 30g of endothelium corneum gigeriae galli. Drying and crushing, and sieving with a 100-mesh sieve for later use;

[2] adding 500g of honey into the medicinal powder prepared in the step, fully stirring and uniformly mixing, and uniformly coating the medicinal powder and auxiliary materials to obtain the honey-honey.

1.2 test animals: SD mice and rats provided by the Experimental animals center of Shanxi university of traditional Chinese medicine;

1.3 statistical treatment: results of the experiment to

Indicating that the significance of the difference between groups was determined using the t-test.

2. Pharmacodynamic test and results:

2.1 anti-inflammatory assay:

effect on swelling of mouse ear: 20 mice are taken and randomly divided into 2 groups, administration is carried out once a day, before administration, a depilatory area with the same size is formed on the back of each group of mice, then test medicines are externally pasted and smeared on the area for continuous administration for 7d, after last administration lh, the front and back surfaces of the right ear of each group of mice are coated with 0.05ml of dimethylbenzene, after 2h of dimethylbenzene, the animals are killed, ears are cut, corresponding parts are punched with 8mm steel lugs, the lugs are weighed, and the difference between the weights of the left ear and the right ear is taken as the swelling degree, and the result is shown in table 1.

TABLE 1 Effect of paraxylene on ear swelling in mice

Note: p <0.01 compared to blank group.

The influence on the permeability of the skin capillary vessels of the mice is as follows: 20 mice were divided into 2 groups at random, and once daily administration was carried out, before the administration, a depilated area of uniform size was formed on the back of each group of mice, and then the test drug was applied to the area by external application and smeared for 7 days, and after the last lh administration, l% Evans blue physiological saline was injected into the tail vein at 0.1ml/10g body weight, and histamine was immediately injected into the abdominal depilated area at 5. mu.g (0.1ml) intradermally. After 20min, the animals were sacrificed, blue-stained skin pieces were cut off, soaked in a mixture of acetone physiological saline (7: 3), and after 24min, centrifuged to take the supernatant, and the result was subjected to color comparison at a wavelength of 610nm in a model 721 spectrophotometer, and is shown in Table 2.

TABLE 2 Effect on mouse skin capillary Permeability

Note: p <0.001 compared to blank group.

Effects on rat paw swelling: 20 rats are randomly divided into 2 groups, before administration, the back of each group of mice forms a depilatory area with the same size, test medicines are externally applied and smeared on the area 24h and lh before inflammation respectively, 7d of continuous administration is carried out, 0.1ml of welan gum is injected into 1% of the corner under the tendon membrane of the right and rear foot of the rat to cause foot swelling, the foot volumes before and after modeling (1, 3, 5 and 7h) are measured by a foot volume method, and the difference between the front and the rear is used for representing the foot swelling degree, and the result is shown in table 3.

Table 3 Effect on carrageenan-induced foot swelling in rats (n ═ 10)

Note: p <0.01, P <0.001 compared to blank.

The anti-inflammatory results in tables 1-3 show that the drug group of the present invention has significant differences in the effects on mouse ear swelling, rat foot swelling, and other tests, compared to the blank group.

2.2 analgesic test

The method has the following effects of torsion-induced reaction of mouse acetic acid: 20 mice are taken and randomly divided into 2 groups, administration is carried out once a day, depilatory areas with the same size are formed on the backs of the mice in each group before administration, then test medicines are externally pasted and smeared on the areas for continuous administration for 5 days, 0.6% glacial acetic acid is injected into the abdominal cavity per mouse after last intragastric administration lh, the times of torsion reactions (belly indent, hind limb extension and hip elevation) of the mice within 20min are observed and recorded, and the results are shown in table 4.

TABLE 4 analgesic Effect on mouse acetic acid writhing response

Note: p <0.001 compared to blank group.

The influence on the threshold value of the electric stimulation tail-flicking pain of the mouse is as follows: 20 mice are taken and randomly divided into 2 groups, administration is carried out once a day, before administration, a depilatory area with the same size is formed on the back of each group of mice, then a test medicament is externally pasted and smeared on the area, administration is continuously carried out for 5 days, after last intragastric administration lh, one electrode is placed on the feet of the mice, the other electrode stimulates the tail, after electrification, the pain threshold value of the mice in tail flicking is observed, and the analgesic inhibition rate is calculated, and the result is shown in Table 5.

The analgesic inhibition rate is (pain threshold of administration group-pain threshold of control group)/pain threshold of control group × 100%

TABLE 5 Effect on electrical stimulation tail-flick threshold in mice

Note: p <0.001 compared to blank group.

Effects on mouse hot plate stimulation on the threshold of foot licking: the mouse is placed on a hot plate apparatus (the temperature is 55 ℃), the time required for the mouse to lick the foot after the mouse is placed on the hot plate apparatus is taken as the pain threshold value of the mouse, and the animal which is unqualified is regarded as the animal when the time for licking the foot is less than 5 seconds or more than 30 seconds or jumps. 20 qualified mice were randomly divided into 2 groups, and once a day, before administration, a depilated area of the same size was formed on the back of each group of mice, and then the test drug was applied to the area by external application for three consecutive days, and 1 hour after the last administration, the pain threshold of the mice was measured, and the results are shown in table 6.

TABLE 6 Effect on Hot plate stimulation of mice on the threshold for licking foot pain

Note: p <0.001 compared to blank group;

the results in tables 4-6 show that the drug group of the invention has significant differences in experiments of body writhing with acetic acid, threshold value of tail flicking pain by electrical stimulation and threshold value of foot licking pain by hot plate stimulation compared with the blank control group.

2.3 Effect on the blood System

First, influence on acute blood stasis type white rat blood rheology indexes

20 rats were randomly divided into 2 groups, administered once a day, the backs of the rats in each group were formed into depilatory regions of uniform size before administration, then test drugs were applied to the regions by external application for three consecutive days, the four limbs and the head of the rat were fixed after the last administration for 1 hour, sterilized with 75% alcohol, placed around the experimental rat in an ice bag, frozen for 1 hour, rewarmed for 5min in 45 ℃ warm water, and then raised for 3 days conventionally, blood was collected and the hemorheology was measured, and the results are shown in tables 7 and 8.

TABLE 7 Effect on rat Whole blood viscosity ((S))

n＝10)

TABLE 8 Effect on rat hemorheology indices (

n＝10)

Note: p <0.01, P <0.001 compared to the blank water group.

The results in tables 7 and 8 show that the drug groups of the present invention have significant differences in whole blood viscosity at high, medium, and low shear rates when compared to the blank control group; in addition, the blood plasma viscosity and the hematocrit are remarkably different, and the results show the great advantages of the medicine group.

Application example two

Example 1

30g of dipsacus asperoides, 30g of drynaria rhizome, 30g of radix baji, 20g of garden balsam stem, 20g of frankincense, 20g of myrrh, 30g of native copper, 20g of medicinal cyathula root, 20g of ground beeltle, 20g of angelica, 20g of safflower, 36g of dragon bone, 20g of rhubarb, 15g of mirabilite, 20g of cuttlebone, 30g of chicken's gizzard-membrane and 500g of honey are taken, different traditional Chinese medicines are respectively ground into powder by a grinding method, are mixed with honey into thin paste to be uniformly applied to a diseased part, are externally wrapped by 1 layer of sinew paper, and are bound by a bandage. Dressing change is carried out every three days.

Example 2

Taking 30g of dipsacus asperoides, 30g of drynaria rhizome, 30g of radix baji, 20g of garden balsam stem, 20g of frankincense, 20g of myrrh, 30g of native copper, 20g of medicinal cyathula root, 20g of ground beeltle, 20g of Chinese angelica, 20g of safflower, 36g of dragon bone, 20g of rhubarb, 15g of mirabilite, 20g of cuttlebone, 30g of chicken's gizzard-membrane and 500g of honey, drying and crushing the raw materials respectively, and sieving the raw materials by a 100-mesh sieve for later use; mixing 500kg of honey with 80ml of azone, adding the medicinal powder prepared in the step, fully stirring and uniformly mixing to prepare paste, coating the paste on auxiliary materials, and adding the paste to a non-woven fabric adhesive plaster to obtain the honey-fried glutinous rice flour. The product can be directly applied to affected part, and the dressing is changed every three days.

Example 3

Wu-Dou, female, 75 years old, Shanxi province, Bao Ji, WeiBin district people. When the patient carelessly falls down during bathing, the left hand lands the ground to cause fracture of the left ulna and radius, and X-ray display is carried out: the fracture of the far end of the radius of the left ulna, the broken end and the displacement are treated in a local three-level hospital, the hospitalization time is 2019-12-12 to 2019-12-20, the left-hand fracture part has obvious swelling and pain during hospitalization, the left-hand movement is completely limited, the treatment is carried out in the local three-level hospital from 2019-12-22, and after the medicine disclosed by the invention is coated, the swelling and pain can be quickly relieved, and meanwhile, the function exercise is given. 2019-12-30 can be dressed and fastened by oneself, the medicine is replaced and smeared every three days, thirty days are fully cured, the fracture of the far end of the radius of the left ulna is rechecked by X-ray at 2020-1-27 (compared with 2019-12-20 tablets), the alignment of the broken ends is good, the fracture line is blurred, the left hand function is completely recovered, the gall disappears, and the dysfunction is not left.

Example 4

Zheng Zhi, female, 52 years old, Gansu Dingxi. Left foot fracture caused by careless tumbling while going out, X-ray display (second hospital of Lanzhou university, 2019-9-29, Dingxi hospital) shows that: the left foot 5 metatarsal bone base is cracked, the bone end slightly deforms, broken bone blocks are dislocated, local soft tissue swelling, left heel bone avulsion fracture, the left foot heel bone still walks with double crutches after being fixed for 3 weeks in a local hospital in the department of Federation, the life needs the care of families, the left foot pain is complained, the left foot pain is difficult to fall asleep at night, 2019.10.21 walks with double crutches to treat the left foot, large bruise and purple swelling of the left foot can be seen after the plaster is opened, the foot joint is stiff, the activity is limited, the swelling and pain can be quickly relieved after the medicine is coated, the left foot heel bone can walk with single crutches at that time, the left foot can walk by oneself after three days when the first re-diagnosis is carried out, the left foot heel bone base is not needed to be supported by families and used with a crutch, the medicine is replaced and smeared every three days, the medicine is healed twenty-a day, and the left foot heel bone base fracture is rechecked on the X line of the local hospital in the department of Federation, (compare with 2019-9-29 tablets), the alignment of broken ends is good, the fracture line is blurred, the left heel bone avulsion fracture line disappears, the left foot function is completely recovered, the swelling and pain disappears, and no functional disorder is left.

Example 5

Yang, woman, 63 years old, and Shaanxi province, the baby chicken, is the person in the Fufeng county. When the patient walks on the workplace, the patient carelessly steps to the air, so that the right foot is frequently fractured, (2019-11-02 Xian medical college Baoji affiliated hospital) X-ray shows that: the foot sole part of the right metatarsus 1, the distal ends of the metatarsus 2, 3 and 4, the fracture of the base part of the metatarsus 2 and 5, 2019-11-3, the foot is treated by sitting in a wheelchair, the right foot can be obviously swollen, the local tenderness is obvious, the skin temperature and the tension are obviously increased compared with the healthy side, the movement of toes is limited, the distal ends of the metatarsus 2, 3 and 4 have bone rubbing feeling, the swelling and pain are obvious after the medicine is coated, the patient can go to sleep quietly in the evening on the day of use, but still needs double-turn auxiliary action, the medicine is coated every three days, the patient can walk under the assistance of single turn when changing medicine for the fourth time (the disease day 13), the patient can walk independently when changing medicine for the sixth time (the disease day 19), the life can be self-managed, the patient can walk freely when changing medicine for the 13 time (the disease day 40), the patient returns to work on the field again, the base part of the right metatarsus 1 in the auxiliary hospital of the western medicine hospital, the patient can be checked again on the X line of 2020, the distal fractures of the 2 nd, 3 rd and 4 th metatarsal bones and the fracture ends of the 2 nd and 5 th metatarsal base parts of the right foot are well aligned (compared with the 2019-11-02 tablets), the fracture lines are fuzzy, the function of the right foot is completely recovered, the swelling and pain disappear, and the functional disorder is not left.

Example 6

And (5) a woman, 72 years old, Baoji City, Shanxi province. The patient can feel that the patient can not walk by himself when the patient carelessly falls down during bathing, the right body touches the ground to cause the avulsion fracture of the femoral greater tuberosity, the activity is limited, the patient can not walk by himself, the patient is injured the next day, the patient can be treated by three families together, the femoral greater tuberosity is swollen, bruised and purple, the local tenderness is obvious, the joint activity is obviously limited, the patient can quickly relieve swelling and pain after being coated with the medicine, the patient can take functional exercise, the patient can walk by himself when changing the medicine for the second time, the patient does not need to be helped by the families, the patient can basically take the patient after going to the toilet and eating by himself, the medicine is changed and coated every three days, the X-ray film is rechecked at thirty-five days, the fracture line of the femoral greater tuberosity at the right fracture is obviously vague.

Example 7

Li Yi, woman, 88 years old, Bao Ji City, Shanxi province. The existing history of double-knee synovitis is more than 20 years, the synovitis of the right knee joint returns after going out and walking with family members, the pain is hard to endure, the activity is difficult, the people can not squat, and the color ultrasonography of the knee joint is found in a local hospital: the right suprapatellar bursal synovitis is treated by the patient with swelling and thickening of soft tissues around the right knee joint in the next day after the disease occurs, the right knee joint is obviously swollen, the skin temperature and the tension are obviously increased compared with the healthy side, the local tenderness is obvious, the joint movement is limited, the patient cannot walk by himself, after the medicine is coated, the swelling and pain are quickly relieved, the patient can take functional exercises, the patient can walk by himself during the second medicine changing, the patient does not need to be helped by family members, the life can be basically self-managed, the patient can go to the toilet and get out of the bed to eat, the medicine is replaced and coated every three days, and the medicine is changed for the third time (the tenth day of the disease occurrence) to review the knee joint: the right suprapatellar bursal synovitis, the soft tissue around the right knee joint swell and thicken, and the patient walks freely.

Example 8

Ma Chi, female, 88 years old, Fengxiang county, Baoji City, Shanxi province. When cooking at home, the left shoulder is hit to the ground, the left shoulder joint is fractured, a doctor visits the local hospital (chicken recovery hospital 2019-9-23), and the X-ray examination shows that: the upper fracture of the left humerus is inserted and displaced, the fracture line is obvious, the pain is hard to endure and the activity is difficult, the left shoulder joint can be treated by the treatment in the third day after the disease, the left shoulder joint can cause left-hand swelling, the left shoulder is taken as the back, the shoulder has a large piece of extravasated blood, the tenderness is obvious, the joint activity is limited, after the medicine is coated, the swelling and the pain can be quickly relieved, the functional exercise can be simultaneously performed, the medicine is changed and coated every three days, the swelling of the left shoulder joint disappears obviously when the medicine is changed for the second time (the third day of diagnosis), the purulence becomes shallow, when the medicine is changed for the fourth time (the 12 th day of diagnosis), the left hand can be eaten (the left hand of a patient), the left shoulder can freely move when the medicine is changed for the tenth time (the thirty days of diagnosis), the help of the family is not needed, the life can be basically self-managed, and the X-ray is rech: in the fracture of the upper part of the left humerus, the fracture line is blurry ahead and slightly insertional displaced, which indicates that the fracture is well healed.

Example 9

Li Ji, male, 14 years old, Baoji City, Shanxi province. When a long jump is set in a physical education course, the left foot is twisted to cause difficulty in walking, and the pictures are taken from 2019-09-26 to a people hospital in the chicken city: the left ankle joint bone results are not obviously abnormal, the external ankle soft tissue is obviously swollen, the patient still needs to walk with the double-crutch assistance after resting for one week at home, treatment is carried out on the patient from 2019-10-4, the patient can see that the internal and external ankles of the left foot are obviously swollen, the subcutaneous extravasated blood is obvious, the local tenderness is obvious, and the patient limps, after being coated with the medicine, the swelling and pain can be quickly relieved, the functional exercise can be simultaneously carried out, the medicine is changed and coated every three days, the swelling of the internal and external ankles of the left foot disappears when changing the medicine for the second time (the third day of treatment), part of stasis is blue and green, the patient can walk by self, the patient can normally go to a lesson, the left foot completely returns to normal when changing the medicine for the fourth time (the twelfth.

Example 10

Liangqi, male, 47 years old, Baoji City, Shanxi province. The rib of the chest is fractured when the bicycle is fallen down. The doctor visits the local hospital (high and new hospital 2019-5-23 in Baoji city) and looks up the X-ray: the fracture of the left front rib 4-7, the broken end has displacement, the treatment is carried out on the left front rib 2 days after the disease occurs, the pain of the left rib area is obvious during deep breathing, cough and turning over, the tenderness of the broken end of the fracture is obvious, subcutaneous extravasated blood can be seen, the activity is limited, the pain can be quickly relieved after the medicine is coated, the functional exercise is given, the sleep can be quietly carried out at night, the medicine is coated every three days, the pain of the left rib area is relieved during the second medicine changing (the third day of diagnosis), most of subcutaneous extravasated blood is dissipated, the medicine is deeply breathed, the cough and the turning over are freely moved during the 8 th medicine changing (the twenty-day of diagnosis), the help of the family is not needed, the life is self-managed, and the X-ray is rechecked in 2019-: and 4, the 4 th to 7 th anterior ribs on the left side are subjected to repeated examination, the broken ends are displaced, and the fracture lines are fuzzy, so that the prognosis is good.

Example 11

Ma Chi, female, 56 years old, Qishan county, Baoji City, Shanxi province. The cook carelessly rolls the thumb into the noodle press during cooking to cause the thumb of the right hand to be fractured (2018-4-29 Cishan county people hospital) and displays the following steps by X-ray: the proximal phalanx of the first finger of the right hand is fractured, poor alignment is achieved, the fracture line is clearly visible, swelling of peripheral soft tissues is obvious, hospitalization operation treatment is recommended in a local hospital, external fixation is given to a brace, pain of a patient is difficult to endure and the patient cannot fall asleep, 2018-05-01 treatment is carried out in our place, swelling of the thumb of the right hand is obvious when the brace is opened, the joint is stiff and cannot be bent, obvious bone rubbing feeling can be achieved, and movement is limited, after the medicine is coated, swelling and pain can be relieved quickly, the patient can fall asleep quietly at night, the medicine can be replaced and coated every three days, when medicine is changed for 5 times (fifteen days in a doctor), chopsticks can be taken for meal, vegetables are cut for meal, when medicine is changed for 13 times (day 40 in a doctor), the function of the right hand is basically recovered, normal work on duty is recovered, when the X-line is rechecked in the local hospital at 2018-05-18, the fracture of the proximal phalanx-bone of the first finger, the fracture line is blurred, the function of the thumb of the right hand is recovered, the swelling and pain disappear, and the dysfunction is not left.

Example 12

Xuezhi, male, 38 years old, Baoji city, Shanxi province. The traditional Chinese medicine has hyperuricemia and gout history, no uric acid reducing medicine is taken, after drinking outside, the swelling and pain of the outer edges of the thumbs of both feet are obvious, the surface skin is high in temperature and cannot walk in the lower reaches, the disease is treated in the next day, the red swelling and the surface skin are obvious, the local tenderness is obvious, the thumbs of both feet cannot walk by themselves, the swelling and pain can be quickly relieved after the medicine is coated, the medicine can get out of bed to move in the afternoon, the medicine is coated and replaced every three days, the red swelling, heat and pain of the outer sides of the thumbs of both feet are obviously relieved before the medicine is changed for the second time, the thumbs can walk by themselves, the family is not needed to help, the life can be self-managed basically, the thumbs can be used for self-going to toilet and getting out of bed to eat, the lesion of the outer sides of the thumbs of both feet can be completely.

Example 13

Zhangqi, male, 45 years old, Baoji City, Shanxi province. When the patient goes out to Changsha and travels, the patient carelessly falls down, the right knee joint lands to cause patellar fracture, the patient is diagnosed in Xingsha hospital (2019-10-27) in Changsha county, and the patient is shown by checking X-ray: comminuted fracture of the right patella with obvious fracture lines. Pain is hard to endure and movement is difficult, the chicken is driven back to the baby chicken by the plane on the same day, the chicken is treated by sitting on the wheelchair on the next day, the swelling of the right knee joint, subcutaneous extravasated blood and local tenderness are obvious, the bone rubbing feeling can be touched, the joint movement is limited, the swelling and the pain can be quickly relieved after the medicine is coated, meanwhile, the medicine is applied for functional exercise, the medicine is replaced and smeared every three days, the swelling of the right knee joint disappears obviously when the medicine is replaced for the second time (the third day of treatment), the purple blood stasis becomes shallow, meanwhile, the patient can move out of bed and lean on a single crutch, when changing medicine for the third time (on the 9 th day of treatment), the swelling of the right knee joint basically disappears, can be put out of bed by oneself without the assistance of family members and walking sticks, the right knee joint can move freely when dressing change is carried out for the eighth time (the 24 th day of treatment), the robot can walk more than five hundred meters continuously, can stand alone by squatting, and can review X-ray display in a central hospital of a chicken city on 2019-11-25 days: the right patella fracture is rechecked, and the fracture line is fuzzy, which indicates that the fracture is well healed.

Example 14

Gongzhi, female, 35 years old, Gangcounty, Bao Ji city, Shanxi province. The left knee joint is inadvertently fallen to land when the high-heeled shoes are worn to cause patella fracture, left patella internal fixation is performed in a local hospital, the left patella internal fixation is performed for 2 weeks after operation, the left knee joint is leaned on the knee to be treated, the left knee joint is taken down, obvious swelling and local tenderness are seen, inner and outer ligaments are stiff, the knee joint is 180 degrees, bending is obviously limited, and joint movement is limited, after the medicine is coated, the swelling is quickly reduced, functional exercise is simultaneously given, the medicine is replaced and coated every three days, the swelling of the left knee joint is obviously disappeared when the medicine is changed for the second time (the third day of treatment), the knee joint can be bent at 130 degrees, the left knee joint can be stepped by self, when the medicine is changed for the fourth time (the 9 days of treatment), the stiff sense of the ligaments on the two sides of the left knee joint is obviously reduced, the knee joint can be bent at 100 degrees, the original place can be stepped by self without assistance of family members and a crutch, can be used for squatting and going to the toilet independently, the knee joint can be bent at 60 degrees, the toilet can continuously walk for more than five hundred meters, and the function is recovered well.

Example 15

Liu, male, 75 years old, Fengxiang county, Bao Ji city, Shanxi province. When the fishing rod falls down when going out, the hip touches the ground to cause the fracture of the thoracic and lumbar vertebrae. The doctor visits the local hospital (Baoji city people hospital 2019-8-23), and looks up the X-ray: chest 12, waist 1 centrum compression fracture, because the patient's basic disease is more, local hospital refuses to give operation treatment, recommend bed rest for three months, after the patient is bedridden for a week, the pain of waist back is difficult to endure, fall asleep poorly at night, and lung infection is complicated, the treatment comes from 10 th day after the onset of disease, chest 12, waist 1 centrum department tenderness is obvious, the activity is restricted, after coating the medicine of the invention, it is very fast to relieve pain, give functional exercise at the same time, can get out of bed at that time and move, change and paint the medicine of the invention every three days, when changing medicine for the second time (see for the third day), the waist pain is lightened, can walk 50 meters continuously, and lung infection heals, when changing medicine for the 9 th time (see for twenty-seven days), the activity is free, need not that the family helps busy, life self-care.

Example 16

Zhangqi, female, 41 years old, high-new-district people in Baoji city, Shanxi province. When the patient walks, the patient carelessly falls down to cause fracture of the right elbow joint (the Lingyun hospital of 2019-11-02 Baoji city) and the X-ray display shows that: comminuted fracture of right humeral medial epicondyle with dislocation of elbow joint. The patient is diagnosed in a central hospital of the chicken city, and the elbow joint three-dimensional CT representation is reviewed: comminuted fracture of external epicondyle of right humerus and humerus capitulum, subluxation of ulnar joint and brachioradiar joint, and swelling of soft tissue around the joint. The patient refuses the operation treatment, the patient is treated in the 2019-11-08 place, the swelling of the right elbow joint, subcutaneous blood stasis and blue skin, the elbow joint deformity and the limited joint movement can be seen after the plaster is removed and the external fixation is removed, the swelling and pain can be quickly relieved after the medicine is coated, the medicine can be changed and coated every three days, the swelling of the right elbow joint disappears obviously when the medicine is changed for the second time (the third day of treatment), the blood stasis and blue skin become shallow, the mobility of the right elbow joint can reach 90-130 degrees when the medicine is changed for the fifth time (the 12 th day of treatment), the patient can eat the medicine by himself, and the mobility of the right elbow joint can reach 80-150 degrees when the medicine is changed for the tenth time (the 27 th day of treatment), and the patient can eat the patient, comb the head and wash the face by himself. 2019-12-30, the X-ray of the second rechecking shows that the comminuted fracture of the medial epicondyle of the right humerus is rechecked, the joint alignment is good, the fracture line is fuzzy, and the function of the right elbow joint is good.

The preferred embodiments of the present disclosure are described in detail, however, the present disclosure is not limited to the details of the above embodiments, and various simple modifications may be made to the technical solution of the present disclosure within the technical concept of the present disclosure, and the simple modifications all belong to the protection scope of the present disclosure.

It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the disclosure of the present invention does not separately describe various possible combinations in order to avoid unnecessary repetition. In addition, any combination of the various embodiments disclosed in the present invention is also possible, and the same should be considered as the disclosure of the invention as long as it does not depart from the idea disclosed in the present invention.

Claims (9)

1. A Chinese medicinal composition for treating fracture, arthritis and acute and chronic soft tissue injury is characterized by comprising effective components and auxiliary materials, wherein the effective components are as follows: 10-50g of dipsacus asperoides, 10-50g of drynaria rhizome, 10-50g of radix angelicae batryae, 5-40g of garden balsam stem, 5-30g of frankincense, 5-40g of myrrh, 10-50g of native copper, 5-40g of medicinal cyathula root, 5-30g of ground beetle, 5-40g of angelica, 5-40g of safflower, 10-55g of keel and 600g of honey 400-.

2. The traditional Chinese medicine composition of claim 1, wherein the effective components further comprise 5-40g of rheum officinale and 5-25g of mirabilite.

3. The traditional Chinese medicine composition of claim 1, wherein the effective ingredients further comprise 5-30g of cuttlebone and 10-40g of endothelium corneum gigeriae galli.

4. The traditional Chinese medicine composition of claim 2 or 3, wherein the effective ingredients are: 15-45g of dipsacus asperoides, 15-45g of drynaria rhizome, 15-50g of radix angelicae gigantis, 10-30g of garden balsam stem, 10-30g of frankincense, 10-35g of myrrh, 10-40g of native copper, 5-30g of medicinal cyathula root, 5-30g of ground beetle, 5-40g of angelica, 5-40g of safflower, 10-50g of dragon bone, 5-40g of rhubarb, 5-25g of mirabilite, 10-30g of cuttlebone, 10-40g of chicken's gizzard-membrane and 600g of honey 400.

5. The traditional Chinese medicine composition of claim 4, wherein the effective ingredients are: 15-45g of dipsacus asperoides, 15-45g of drynaria rhizome, 15-50g of radix angelicae gigantis, 10-30g of garden balsam stem, 10-30g of frankincense, 10-30g of myrrh, 20-40g of native copper, 10-30g of medicinal cyathula root, 10-30g of ground beetle, 10-30g of angelica, 5-40g of safflower, 22-46g of dragon bone, 10-25g of rhubarb, 10-20g of mirabilite, 20-30g of cuttlebone, 20-30g of endothelium corneum gigeriae galli and 500g of honey.

6. The traditional Chinese medicine composition of claim 5, wherein the effective ingredients are: 30g of dipsacus asperoides, 30g of drynaria rhizome, 30g of radix baji, 20g of garden balsam stem, 20g of frankincense, 20g of myrrh, 30g of native copper, 20g of medicinal cyathula root, 20g of ground beetle, 20g of angelica, 20g of safflower, 36g of dragon bone, 20g of rhubarb, 15g of mirabilite, 20g of cuttlebone, 30g of endothelium corneum gigeriae galli and 500g of honey.

7. The Chinese medicinal composition according to any one of claims 1 to 6, wherein the composition is added with pharmaceutically acceptable excipients commonly used in pharmacy to prepare an external patch.

8. A method of preparing the traditional Chinese medicine composition of claim 1, 2 or 3, characterized in that:

[1] respectively drying and crushing the 16 raw material medicines, and sieving the raw material medicines by a 100-mesh sieve for later use;

[2] mixing 500kg of honey with 80ml of azone, adding the medicinal powder prepared in the step, fully stirring and uniformly mixing to prepare paste, coating the paste on auxiliary materials, and adding the paste to a non-woven fabric adhesive plaster to obtain the honey-fried glutinous rice flour.

9. The use of the Chinese medicinal composition of claim 1, 2 or 3 in the preparation of medicaments for treating bone fracture, arthritis, acute and chronic soft tissue injury, etc.