CN103405740A - Chinese medicine composition for external use and preparation method thereof - Google Patents
Chinese medicine composition for external use and preparation method thereof Download PDFInfo
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- CN103405740A CN103405740A CN2013103696833A CN201310369683A CN103405740A CN 103405740 A CN103405740 A CN 103405740A CN 2013103696833 A CN2013103696833 A CN 2013103696833A CN 201310369683 A CN201310369683 A CN 201310369683A CN 103405740 A CN103405740 A CN 103405740A
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Abstract
The invention relates to a Chinese medicine composition for external use and a preparation method thereof. The Chinese medicine composition comprises the following 16 raw material medicines: radix aconiti preparata, prepared kusnezoff monkshood root, rhizoma corydalis, pepper, radix clematidis, rhizoma zingiberis, radix achyranthis bidentatae, Rhizoma Drynariae, radix angelicae pubescentis, radix aconite, Ligusticum wallichii, camphor, resina draconis, frankincense and myrrh. The composition with pharmaceutically common auxiliary materials is prepared into various external pastes; the preparation method of the Chinese medicine composition has the characteristics of being simple, feasible, scientific, reasonable and the like.
Description
Technical field
The present invention relates to Chinese medicine composition of a kind of external and preparation method thereof, belong to the pharmaceutical preparations technology field.
Background technology
The arthromyodynia of the traditional Chinese medical science is common clinical, frequently-occurring disease, is similar to the rheumatism category of the autoimmune disease of modern medicine, such as rheumatoid arthritis, rheumatic arthritis, osteoarthritis, neck and lumbar pain and bony spur hypertrophy disease etc.Its clinical symptoms main manifestations has the position pain such as joint, skin, muscles and bones, or swelling, morning are stiff, numbness is weighing, or joint stuffiness, even joint swelling deformation etc.For above disease, western medicine is without any the way of radical cure, and motherland's medical science has therapeutical effect very significantly.This disease Traditional chinese medicine medicament treatment can be divided into treatment by oral administration of medicines and external treatment; The oral preparations such as the main oral decoction for the treatment of by oral administration of medicines, external treatment mainly smoke with Chinese herbal medicine and wash, external application, acupuncture, massage etc., but no matter treatment by oral administration of medicines or external treatment, and its purpose all be take activating blood circulation to dissipate blood stasis, pain stop and anti-inflammation and is the rule for the treatment of.
External plaster is a pith in Chinese medicine, is one of five large pharmaceutical dosage form balls, loose, cream, pellet, soup.Outer patch medicine can not only be treated some surgical disease, for the illness of some internal medicine, certain curative effect is also arranged.Simultaneously, it has advantages of easy to use and easy to carry.So, be subject at all times working people's attention and generally application, to ensureing people ' s health, play effect preferably.Just oneself has had record in " interior warp " in the application of plaster.The simple wooden tablets or slips for writing of excavating on slope, Gansu Wuwei Xian Han beach in 1962, have treatment " all kinds of diseases and ailments plaster side " and " married woman plaster side " in it.The Eastern Han Dynasty's outstanding physician's Zhang Zhongjing in the last years of a dynasty or reign has the Holy Benevolent Prescriptions of " medical secrets of official ", Song dynasty of " very heavy wing side ", the Wang Tao of " General Treatise on the Cause and Symptoms of Diseases ", the Tang Dynasty Sun Simiao of " Cui Huafang ", the Sui Dynasty Chao Yuanfang (550-630 A.D.) in " Handbook of Prescriptions for Emergencies ", the Western Jin Dynasty of " a maneuver of massage by rubbing the affected part with ointment for treating arthralgia and skin disease therapies should be practised to clear the nine orifices ": Ge Hong and " prescription of peaceful benevolent dispensary " etc. that leaf fat and black plaster are all arranged in its masterpiece " Treatise on Febrile and Miscellaneous Disease ".Square, the use of the Compendium of Material Medica of Li Shizhen (1518-1593 A.D.) to plaster, put down in writing quite detailed.
Plaster claims " plaster applying a plaster for therapeutic purpose " the earliest, and Han dynasty starts to be called " plaster "～" external treatment ".Han dynasty " Huatuo god cream " is for controlling the cream of skin ulcer wound, until " the reason Chongqing parallel prose " that Qing Dynasty's Wu Shi machine is write had further elaboration to plaster.This book is famous Chinese plaster monograph, and has proposed famous " the one, pull out, the one, cut " theory.That pulls out is sick from going out, and the heresy of cutting is autotomyed, and its scientific judgment has played reference function to descendant's development and application plaster.All be shaped with dissimilar plaster or subsides each period in successive dynasties.Plaster belongs to a kind of in transdermal absorption formulation, the advantage that it possesses Transdermal absorption, be mainly manifested in following some:
(1) drug absorption is not subjected to the interior PH of digestive tract, food and medicine at effect of complicate factors such as intestinal traveling times;
(2) avoid the first pass effect of medicine at liver, improved bioavailability;
(3) sustainable control injection speed;
(4) can avoid peak valley phenomenon, reduce the toxic and side effects of medicine;
(5) can produce lasting, constant and controlled blood drug level, and then improve curative effect, thereby alleviate untoward reaction;
Pain while (6) avoiding injecting;
(7) reduce administration number of times and dosage;
(8) agents area is at body surface, and interruption of the administration, easily accepted by patient at any time.
External treatment of tcm is an important component part of tcm therapy, the documents and materials that have a long history and enrich, widely application in the treatment of local skin or systemic disease especially some difficult miscellaneous diseases.But aspect the Chinese medicine transdermal study, complexity due to Chinese medicine ingredients, the detection index of selection science and evaluation methodology are carried out quantitative study and are remained in certain difficulty. a lot of transdermal absorption formulations, such as various plaster, lotion, applicator etc. are arranged in traditional preparation.The Chinese medicine transdermal absorption formulation is developed the modern Chinese medicine transdermal absorption formulation for us, has valuable reference value.The broad sense percutaneous drug administration preparation comprises ointment, plaster, paster, membrane, varnish, transdermal patches, aerosol etc.
Plaster is a kind of in transdermal absorption formulation.Its kind is a lot, and the plaster of existing main application has two kinds of dosage forms: the one, " black plaster ", and it is traditional, curative effect is dosage form preferably; The one, " white plaster ", be made into the adhesive plaster sample, and mesh is arranged, and the energy blowing air, prevent skin allergy, and curative effect is better, portably uses conveniently.Now more for the research of cataplasma both at home and abroad, it is mainly used for anti-inflammatory analgesic.At first cataplasma was succeeded in developing in Japan the seventies, due to advantages such as dosage is accurate, blood drug level stable, allergic stimulated is little, use comfort and convenients, in Japan, deeply was subjected to patient's welcome, and successfully squeezed into European & American Market the eighties.China is started in the initial stage eighties to the research of cataplasma, and along with the development of medical industry, development was very fast in recent years.Cataplasma is to take water-soluble high-molecular material to be main matrix, adds medicine, through refining close, be coated with, the operation such as shearing, be prepared from.
Between this, technical scheme of the present invention just is being based on to be created successful for the basic purpose of curing of this type of persistent ailment, it is to form with the 16 flavor Chinese herbal medicine compatibilities such as Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, to improve cure rate, to alleviate pathological symptom, improve drug bioavailability, and easy, the taking convenience of preparation molding etc. is evaluation index, a kind of external plaster of finally making.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition of external, said composition has proportioning science, reasonable, characteristics evident in efficacy.
Another object of the present invention is to provide the preparation method of said composition.
The composition and ratio of Chinese medicine composition of the present invention is:
Radix Aconiti Preparata 400-800g, Radix Aconiti Kusnezoffii Preparata 400-800g, Rhizoma Corydalis 600-1000g, Fructus Piperis 400-800g, Radix Clematidis 400-800g, Rhizoma Zingiberis 600-1000g, Radix Achyranthis Bidentatae 400-800g, Rhizoma Drynariae 400-800g, Radix Angelicae Pubescentis 400-800g, Radix aconiti szechenyiani 400-800g, Rhizoma Chuanxiong 400-800g, Camphora 100-300g, Sanguis Draxonis 200-400g, Rhizoma Et Radix Notopterygii 400-800g, Olibanum 400-800g, Myrrha 400-800g;
Wherein, preferably proportioning is:
Radix Aconiti Preparata 600g, Radix Aconiti Kusnezoffii Preparata 600g, Rhizoma Corydalis 800g, Fructus Piperis 600g, Radix Clematidis 600g, Rhizoma Zingiberis 800g, Radix Achyranthis Bidentatae 600g, Rhizoma Drynariae 600g, Radix Angelicae Pubescentis 600g, Radix aconiti szechenyiani 600g, Rhizoma Chuanxiong 600g, Camphora 200g, Sanguis Draxonis 300g, Rhizoma Et Radix Notopterygii 600g, Olibanum 600g, Myrrha 600g.
Chinese medicine composition described in above technical scheme, then add common pharmaceutic adjuvant, and can be made into external use plaster according to conventional technical method.
The application of Chinese medicine composition described in above technical scheme in the medicines such as preparation treatment cervical spondylosis, cervical osteophytes hypertrophy, prolapse of lumbar intervertebral disc, lumbar muscle strain, lumbar vertebra hyperosteogeny, sciatica, degenerative osteoarthritis, knee joint bony spur, synovitis, rheumatoid arthritis.
The Chinese medicine composition of the above composition and ratio, its preparation method operating procedure is:
[1] by described 16 flavor crude drug, dry and pulverizing, after 120 mesh sieves, continue to employ;
[2] azone of 8-12kg Mel, 4-8kg lanoline, 3-5kg glycerol and 100-300ml is mixed, then add prepared medicated powder in step (1), fully after stirring and evenly mixing, standing 48h, with tablet machine, be depressed into the tablet of 1-2mm thickness, and add to the non-woven fabrics sticker, obtain;
Wherein, preferably technical scheme is:
[1] by described 16 flavor crude drug, dry and pulverizing, after 120 mesh sieves, continue to employ;
[2] azone of 10kg Mel, 6kg lanoline, 4kg glycerol and 200ml is mixed, then add prepared medicated powder in step (1), fully after stirring and evenly mixing, standing 48h, be depressed into the tablet of 1-2mm thickness with tablet machine, and add to the non-woven fabrics sticker, obtains.
It is below our pharmacodynamic study to the present composition, in order to simplify experimental implementation, save research expenditure, follow the experiment principle of parallel control, thereby the creativeness of the outstanding technical solution of the present invention of science more, we take technical scheme group in the present invention and carry out representative studies as representative, and so this can derive for those skilled in the art fully thus, understand the beneficial effect of other parameter point technical scheme in the application
Therefore the technology of the present invention content and drug effect result never are limited to this scope.
1 test material and result processing method:
1.1 the preparation of trial drug of the present invention:
[1] get 16 flavor crude drug of following weight proportion: Radix Aconiti Preparata 600g, Radix Aconiti Kusnezoffii Preparata 600g, Rhizoma Corydalis 800g, Fructus Piperis 600g, Radix Clematidis 600g, Rhizoma Zingiberis 800g, Radix Achyranthis Bidentatae 600g, Rhizoma Drynariae 600g, Radix Angelicae Pubescentis 600g, Radix aconiti szechenyiani 600g, Rhizoma Chuanxiong 600g, Camphora 200g, Sanguis Draxonis 300g, Rhizoma Et Radix Notopterygii 600g, Olibanum 600g, Myrrha 600g, dry also pulverizing, after 120 mesh sieves, continue to employ;
[2] azone of 10kg Mel, 6kg lanoline, 4kg glycerol and 200ml is mixed, then add prepared medicated powder in step (1), fully after stirring and evenly mixing, standing 48h, be depressed into the tablet of 1-2mm thickness with tablet machine, and add to the non-woven fabrics sticker, obtains.
1.2 experimental animal: SD mice, rat are provided by The Fourth Military Medical University's Experimental Animal Center;
1.3 statistical procedures: experimental result with
Mean, adopt the t check, measure the significance of group difference.2. the test of pesticide effectiveness and result:
2.1 antiinflammatory test:
(1) on the impact of mice ear: get 20 of mices, be divided at random 2 groups, be administered once every day, before administration, back of each group mice is formed to depilation of the same size regional, then by the trial drug external patch, smear in this zone, successive administration 7d, after last administration 1h, be coated with dimethylbenzene 0.05ml in the mouse right ear positive and negative, to 2h after dimethylbenzene, put to death animal, cut ear, in corresponding site, sweep away auricle with the 8mm steel drift, weigh, take the difference of left and right ear weight as the swelling degree, the results are shown in Table 1.
Table 1 xylol causes the impact of mice ear
| Group | Dosage (the g crude drug/kg) | n | Ear thickness (mg) |
| The blank group | - | 10 | 12.11±1.04 |
| Of the present invention group | 1.2 | 10 | 6.74±1.05 *** |
Annotate: with the blank group, compare * * * P<0.01.
(2) on the impact of mouse skin capillary permeability: get 20 of mices, be divided at random 2 groups, be administered once every day, before administration, back of each group mice is formed to depilation of the same size regional, then by the trial drug external patch, smear in this zone, successive administration 7d, after last administration 1h, tail vein injection 1% Azo-Blue normal saline 0.1ml/10g body weight, and in abdominal part depilation place Intradermal, inject histamine 5 μ g (0.1ml) immediately.After 20min, put to death animal, cut indigo plant and dye skin graft, be soaked in acetone normal saline (7:3) mixed liquor, after 24min, the centrifuging and taking supernatant, in 721 type spectrophotometer wavelength 610nm colorimetrics, the results are shown in Table 2.
The impact of table 2 on the mouse skin capillary permeability
| Group | Dosage (the g crude drug/kg) | n | Indigo plant is dyed the optical density (0D) of skin graft |
| The blank group | - | 10 | 0.084±0.051 |
| Of the present invention group | 1.2 | 10 | 0.027±0.021 *** |
Annotate: with the blank group, compare * * * P<0.001.
(3) on the impact of rat paw edema: get 20 of rats, be divided at random 2 groups, before administration, the back of each group mice formed to depilation of the same size zone, before Yu Zhiyan 24h, 1h respectively by the trial drug external patch, smear in this zone, successive administration 7d, under Rat Right metapedes plantar aponeurosis, to inject 1% jiao Lay glue 0.1ml/ again, cause foot swelling, with sufficient volumetric method, measure the sufficient volume of moulding forward and backward (1,3,5,7h), poor with front and back, mean the foot swelling degree, the results are shown in Table 3.
Table 3 on Carrageenan causes the impact (n=10) of rat paw edema
Annotate: with the blank group, compare * * P<0.01, * * * P<0.001.
Antiinflammatory result by table 1-3 shows, compares with the blank group, and medicine group of the present invention, all have the significance difference opposite sex in the tests such as the impact on mice ear, rat paw edema.
2.2 analgesic experiment
(1) mice acetic acid is caused to the effect of writhing response: get 20 of mices, be divided at random 2 groups, be administered once every day, before administration, the back of each group mice formed to depilation of the same size zone, then by the trial drug external patch, smear in this zone, successive administration 5 days, after last gastric infusion 1h, lumbar injection 0.6% glacial acetic acid 0.2ml/ is only, observe and record the number of times of mouse writhing reaction in 20min (abdominal part indent, stretching, extension hind leg, buttocks are raised), the results are shown in Table 4.
The analgesic activity of table 4 pair mice acetic acid twisting reaction
| Group | Dosage (g crude drug amount/kg) | n | Writhing number of times (t=20min) |
| The blank group | - | 10 | 26.54±3.21 |
| Medicine group of the present invention | 1.2 | 10 | 8.41±4.41 *** |
Annotate: with the blank group, compare * * * P<0.001.
(2) on the impact of mice electricity irritation whipping pain threshold: get 20 of mices, be divided at random 2 groups, be administered once every day, before administration, back of each group mice is formed to depilation of the same size regional, then by the trial drug external patch, smear in this zone, successive administration 5 days, after last gastric infusion 1h, an electrode is put on the mice foot to another electrode stimulating afterbody, after energising, pain threshold while observing the mice whipping, and calculate the analgesia suppression ratio, the results are shown in Table 5.
Analgesia suppression ratio=(administration group pain threshold-matched group pain threshold)/matched group pain threshold * 100%
The impact of table 5 on mice electricity irritation whipping pain threshold
Annotate: with the blank group, compare * * * P<0.001.
(3) the mice hot plate is stimulated to the impact of licking the pain in foot threshold value: get mice and be placed in (55 ℃ of temperature) on hot-plate instrument, mice is placed in hot-plate instrument in vain to the pain threshold of metapedes required time as this Mus occurring licking, allly lick the metapedes time and be less than 5 seconds or be greater than 30 seconds or the leaper, be considered as defective animal, give it up.Get 20 of qualified mices, be divided at random 2 groups, be administered once every day, before administration, back of each group mice is formed to depilation of the same size regional, then by the trial drug external patch, smear in this zone continuous three days, after the last administration 1 hour, start to measure the mice pain threshold, the results are shown in Table 6.
Table 6 stimulates the impact of licking the pain in foot threshold value on the mice hot plate
| Group | Dosage (the g crude drug/kg) | n | Pain threshold (min) |
| The blank group | - | 10 | 23.58±1.14 |
| Medicine group of the present invention | 1.2 | 10 | 26.25±1.35 *** |
Annotate: with the blank group, compare * * * P<0.001;
Relatively, the two mice acetic acid twisting, electricity irritation whipping pain threshold, hot plate stimulate to lick in the experiment of pain in foot threshold value all significant difference for the result demonstration of table 4-6, medicine group of the present invention and blank group.
2.3 the impact on blood system
(1) on the impact of stasis syndrome type rat hemorheology index
Get 20 of rats, be divided at random 2 groups, be administered once every day, before administration, back of each group mice is formed to depilation of the same size regional, then by the trial drug external patch, smear in this zone, continuous three days, after last administration 1h, fixedly rat extremity and head respectively, use 70% alcohol disinfecting, around experimental rat, put ice bag, freezing 1.5h, rewarming 5min in 45 ℃ of warm water, then conventional the raising after 3 days, take a blood sample and survey hemorheology numerical value, the results are shown in Table 7 and 8.
The impact of table 7 on the rat whole blood viscosity
The impact of table 8 on the hemorheology of rat index
Annotate: with blank water group, compare * * P<0.01, * * * P<0.001.
Table 7 and 8 result show, no matter medicine group of the present invention and blank group relatively, are during at high, medium and low shear rate, all to have significant difference in whole blood viscosity; In addition, significant difference is also being arranged aspect plasma viscosity and packed cell volume, the huge advantage that embodies medicine group of the present invention that above result is all given prominence to.
Below us by the instantiation of medicine of the present invention application in the middle of clinical, in order to again fully show the beneficial effect of said composition:
Case 1: thunder 56 years old, changed prolapse of lumbar intervertebral disc 12 years, heavy when light during lumbago and skelalgia, when serious, can not leave the bed, stand up difficulty, the immediate cause aggravation of suffering from cold, lumbago, lumbosacral region distending pain with the radial pain of left side lower limb, stick plaster 4 of the present invention and paste, and is affixed on respectively yao yang kuan, Huantiao, aids the border areas, bl.Low back lower limb on the one not pain is obviously alleviated, and can leave the bed and walk about indoor after two days, and uncomfortable basic disappearance of pain after five days, can arrive outdoor stroll and buy vegetables etc., paste continuously the medicine fortnight after pain thoroughly the disappearance activity is the same from like normal person.After half a year, pay a return visit again without recurrence.
Case 2: Liu 49 years old, suffer from strength vertebra disease more than ten years, each recurrence is that the strength vertebra is felt stiff pain, rotate not freely or meciless with forearm or numbness of the fingers, in the recent period because being busy with one's work, after fatigue, cervical vertebra right side pain with local muscle strength right side forearm numbness of the fingers, oral Chinese medicine and western medicine had no and alleviates on the 5th, sticking plaster 3 of the present invention pastes, be affixed on respectively DAZHUI acupoint, Jianjing point, the shou san li cave, after two days, pain substantially disappears and greatly takes a turn for the better, hand-held numbness is slightly got better and is turned, paste continuously medicine after ten days, numbness of hand wood obviously alleviates, after three weeks, see disappearance in pain and numbness.After four months, pay a return visit and have no recurrence.
Case 3: health 48 years old, the retired worker, the gonalgia more than 2 years X-rays in right side show that knee joint bony spur and knee joint narrow down, fatigue is rear or the rear pain of suffering from cold is obvious, but the pneumonedema expansible band has coolness difficulty on foot, sticks plaster 3 of the present invention and pastes, be affixed on respectively point ex-le 5, sp 6, volt rabbit cave, after three days, pain disappearance coolness disappears, and freely, the later stage is again without recurrence in walking.
Case 4: Wang 48 years old, suffered from gonarthromeningitis more than 6 years, each tired, recurrence of catching cold, the knee joint swelling pain can not be walked, and sticks plaster 2 of the present invention and pastes, and took effect the same day.Paste after a night swelling pain that disappears and greatly alleviate, after three days, disease is eliminated fully, pays a return visit not recurrence in a year.
Case in the middle of above-mentioned clinical practice, comprehensively set forth the charge-coupled good therapeutic effect of Chinese drug-treated group of the present invention from different diseases aspect, strong disclose the beneficial effect that the technical program is outstanding.
The specific embodiment
Be below the specific embodiment of content of the present invention, for setting forth present specification, want the technical scheme of technical solution problem, help those skilled in the art to understand content of the present invention, but the realization of technical solution of the present invention is not limited to these embodiment.
Embodiment 1
The A raw material forms and proportioning: Radix Aconiti Preparata 600g, Radix Aconiti Kusnezoffii Preparata 600g, Rhizoma Corydalis 800g, Fructus Piperis 600g, Radix Clematidis 600g, Rhizoma Zingiberis 800g, Radix Achyranthis Bidentatae 600g, Rhizoma Drynariae 600g, Radix Angelicae Pubescentis 600g, Radix aconiti szechenyiani 600g, Rhizoma Chuanxiong 600g, Camphora 200g, Sanguis Draxonis 300g, Rhizoma Et Radix Notopterygii 600g, Olibanum 600g, Myrrha 600g;
The B preparation method operates as follows:
[1] by the flavor of 16 described in A crude drug, dry and pulverizing, after 120 mesh sieves, continue to employ;
[2] azone of 10kg Mel, 6kg lanoline, 4kg glycerol and 200ml is mixed, then add prepared medicated powder in step (1), fully after stirring and evenly mixing, standing 48h, be depressed into the tablet of 1-2mm thickness with tablet machine, and add to the non-woven fabrics sticker, obtains.
Embodiment 2
The A raw material forms and proportioning: Radix Aconiti Preparata 800g, Radix Aconiti Kusnezoffii Preparata 800g, Rhizoma Corydalis 600g, Fructus Piperis 400g, Radix Clematidis 400g, Rhizoma Zingiberis 1000g, Radix Achyranthis Bidentatae 800g, Rhizoma Drynariae 800g, Radix Angelicae Pubescentis 400g, Radix aconiti szechenyiani 400g, Rhizoma Chuanxiong 400g, Camphora 100g, Sanguis Draxonis 400g, Rhizoma Et Radix Notopterygii 400g, Olibanum 800g, Myrrha 800g;
The B preparation method operates as follows:
[1] by the flavor of 16 described in A crude drug, dry and pulverizing, after 120 mesh sieves, continue to employ;
[2] azone of 8kg Mel, 4kg lanoline, 3kg glycerol and 100ml is mixed, then add prepared medicated powder in step (1), fully after stirring and evenly mixing, standing 48h, be depressed into the tablet of 1-2mm thickness with tablet machine, and add to the non-woven fabrics sticker, obtains.
Embodiment 3
The A raw material forms and proportioning: Radix Aconiti Preparata 400g, Radix Aconiti Kusnezoffii Preparata 400g, Rhizoma Corydalis 1000g, Fructus Piperis 800g, Radix Clematidis 800g, Rhizoma Zingiberis 600g, Radix Achyranthis Bidentatae 400g, Rhizoma Drynariae 400g, Radix Angelicae Pubescentis 800g, Radix aconiti szechenyiani 800g, Rhizoma Chuanxiong 800g, Camphora 300g, Sanguis Draxonis 200g, Rhizoma Et Radix Notopterygii 800g, Olibanum 400g, Myrrha 400g;
The B preparation method operates as follows:
[1] by the flavor of 16 described in A crude drug, dry and pulverizing, after 120 mesh sieves, continue to employ;
[2] azone of 12kg Mel, 8kg lanoline, 5kg glycerol and 300ml is mixed, then add prepared medicated powder in step (1), fully after stirring and evenly mixing, standing 48h, be depressed into the tablet of 1-2mm thickness with tablet machine, and add to the non-woven fabrics sticker, obtains.
Embodiment 4
The A raw material forms and proportioning: Radix Aconiti Preparata 700g, Radix Aconiti Kusnezoffii Preparata 700g, Rhizoma Corydalis 700g, Fructus Piperis 500g, Radix Clematidis 500g, Rhizoma Zingiberis 700g, Radix Achyranthis Bidentatae 500g, Rhizoma Drynariae 500g, Radix Angelicae Pubescentis 500g, Radix aconiti szechenyiani 500g, Rhizoma Chuanxiong 500g, Camphora 150g, Sanguis Draxonis 250g, Rhizoma Et Radix Notopterygii 500g, Olibanum 500g, Myrrha 500g;
The B preparation method operates as follows:
[1] by the flavor of 16 described in A crude drug, dry and pulverizing, after 120 mesh sieves, continue to employ;
[2] azone of 9kg Mel, 5kg lanoline, 4kg glycerol and 200ml is mixed, then add prepared medicated powder in step (1), fully after stirring and evenly mixing, standing 48h, be depressed into the tablet of 1-2mm thickness with tablet machine, and add to the non-woven fabrics sticker, obtains.
Claims (6)
1. the Chinese medicine composition of an external is characterized in that it is comprised of the raw material of following weight proportion: Radix Aconiti Preparata 400-800g, Radix Aconiti Kusnezoffii Preparata 400-800g, Rhizoma Corydalis 600-1000g, Fructus Piperis 400-800g, Radix Clematidis 400-800g, Rhizoma Zingiberis 600-1000g,
Radix Achyranthis Bidentatae 400-800g, Rhizoma Drynariae 400-800g, Radix Angelicae Pubescentis 400-800g, Radix aconiti szechenyiani 400-800g, Rhizoma Chuanxiong 400-800g, Camphora 100-300g, Sanguis Draxonis 200-400g, Rhizoma Et Radix Notopterygii 400-800g, Olibanum 400-800g, Myrrha 400-800g.
2. Chinese medicine composition as claimed in claim 1, is characterized in that it is comprised of the raw material of following weight proportion: Radix Aconiti Preparata 600g, Radix Aconiti Kusnezoffii Preparata 600g, Rhizoma Corydalis 800g, Fructus Piperis 600g, Radix Clematidis 600g, Rhizoma Zingiberis 800g, Radix Achyranthis Bidentatae 600g, Rhizoma Drynariae 600g, Radix Angelicae Pubescentis 600g, Radix aconiti szechenyiani 600g, Rhizoma Chuanxiong 600g, Camphora 200g, Sanguis Draxonis 300g, Rhizoma Et Radix Notopterygii 600g, Olibanum 600g, Myrrha 600g.
3. Chinese medicine composition as claimed in claim 1 or 2, is characterized in that, said composition adds pharmaceutic adjuvant commonly used on pharmaceutics to make external use plaster.
4. one kind prepares the method for Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that:
[1] by described 16 flavor crude drug, dry and pulverizing, after 120 mesh sieves, continue to employ;
[2] azone of 8-12kg Mel, 4-8kg lanoline, 3-5kg glycerol and 100-300ml is mixed, then add prepared medicated powder in step (1), fully after stirring and evenly mixing, standing 48h, with tablet machine, be depressed into the tablet of 1-2mm thickness, and add to the non-woven fabrics sticker, obtain.
5. preparation method as claimed in claim 4, is characterized in that; In step [2], the weight of Mel, lanoline, glycerol is respectively 10kg Mel, 6kg lanoline, 4kg glycerol, and the volume of azone is 200ml.
6. the application of Chinese medicine composition as claimed in claim 1 or 2 in the medicines such as preparation treatment cervical spondylosis, cervical osteophytes hypertrophy, prolapse of lumbar intervertebral disc, lumbar muscle strain, lumbar vertebra hyperosteogeny, sciatica, degenerative osteoarthritis, knee joint bony spur, synovitis, rheumatoid arthritis.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106726101A (en) * | 2017-01-11 | 2017-05-31 | 郑州紫德堂生物科技有限公司 | A kind of wax therapy Chinese medicine wax stone and preparation method thereof |
| WO2018113200A1 (en) * | 2016-12-21 | 2018-06-28 | 上海活尔生物科技有限公司 | External traditional chinese medicine preparation for diminishing inflammation, relieving pain and promoting fast healing, and preparation method therefor |
| CN109568541A (en) * | 2018-12-20 | 2019-04-05 | 罗国亮 | A kind of black plaster for treating treating rheumatic ostealgia and preparation method thereof and application |
| CN111529584A (en) * | 2020-06-23 | 2020-08-14 | 段景怡 | A Chinese medicinal composition for treating fracture, arthritis and acute and chronic soft tissue injury, and its preparation method |
| CN113730543A (en) * | 2021-10-15 | 2021-12-03 | 吉林省迎旭药业有限公司 | Traditional Chinese medicine plaster formula and preparation process thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062219A (en) * | 2007-06-11 | 2007-10-31 | 吴登清 | Ointment for treating pain |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062219A (en) * | 2007-06-11 | 2007-10-31 | 吴登清 | Ointment for treating pain |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018113200A1 (en) * | 2016-12-21 | 2018-06-28 | 上海活尔生物科技有限公司 | External traditional chinese medicine preparation for diminishing inflammation, relieving pain and promoting fast healing, and preparation method therefor |
| CN106726101A (en) * | 2017-01-11 | 2017-05-31 | 郑州紫德堂生物科技有限公司 | A kind of wax therapy Chinese medicine wax stone and preparation method thereof |
| CN106726101B (en) * | 2017-01-11 | 2018-11-23 | 郑州紫德堂生物科技有限公司 | A kind of wax therapy Chinese medicine wax stone and preparation method thereof |
| CN109568541A (en) * | 2018-12-20 | 2019-04-05 | 罗国亮 | A kind of black plaster for treating treating rheumatic ostealgia and preparation method thereof and application |
| CN111529584A (en) * | 2020-06-23 | 2020-08-14 | 段景怡 | A Chinese medicinal composition for treating fracture, arthritis and acute and chronic soft tissue injury, and its preparation method |
| CN113730543A (en) * | 2021-10-15 | 2021-12-03 | 吉林省迎旭药业有限公司 | Traditional Chinese medicine plaster formula and preparation process thereof |
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