CN103263621B - A kind of pharmaceutical composition for the treatment of lumbar spondylosis - Google Patents
A kind of pharmaceutical composition for the treatment of lumbar spondylosis Download PDFInfo
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- CN103263621B CN103263621B CN201310218791.0A CN201310218791A CN103263621B CN 103263621 B CN103263621 B CN 103263621B CN 201310218791 A CN201310218791 A CN 201310218791A CN 103263621 B CN103263621 B CN 103263621B
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Abstract
The present invention discloses a kind of pharmaceutical composition for the treatment of lumbar spondylosis, and said composition is made up of crude drug such as Cornu Cervi, Rhizoma Acori Graminei, Pheretima, Vermilion, Spina Gleditsiae, Camphora, Rhizoma Homalomenae, Rhizoma Drynariae, Radix Cucubali, Ramulus Sambuci Williamsii, Rhizoma Paridis, Herba Lycopodii, Herba Dendrobii, Herba Senecionis Scandentis, Lignum Sappan, Radix Cudraniae, Moschus.Pharmaceutical composition of the present invention conveniently technique adds customary adjuvant and makes the emplastrum of clinical acceptance, ointment, spray, liniment or tincture.Pharmaceutical composition of the present invention has blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian, deep effect of having one's ideas straightened out.To treatment lumbar vertebra hyperosteogeny, prolapse of lumbar intervertebral disc, lumbar muscle strain, the lumbar spondylosis Be very effective such as rheumatism or rheumatoid lumbago, have no side effect.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of lumbar spondylosis.
Background technology
Lumbar vertebra: vertebral body is larger; Spinous process tabular level stretches to rear, and relief width between adjacent spinous can do lumbar puncture, and zygapophysial joints face is sagittal plain. and human body has five lumbar vertebras, and each lumbar vertebra is made up of the vertebral body in front and the adnexa at rear.The Etiological of hyperosteogeny is relevant with the degeneration of articular cartilage, and the hyperosteogeny of lumbar vertebra is because after the middle age, along with the increase at age, the each histiocytic physiological function of body also fails aging gradually, the intervertebral disc of degenerating loses moisture content, narrowing of intervertebral space gradually, and fibrous ring relaxes to periphery bulging, vertebral body is unstable, fibrous ring is torn outward in vertebral rim, causes vertebral pulp outstanding, by the periosteum jack-up of posterior longitudinal ligament, produce new bone below it, form bony spur or hyperosteogeny.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of lumbar spondylosis.
The present invention is achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention consists of:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Pharmaceutical composition of the present invention conveniently technique adds customary adjuvant and makes the emplastrum of clinical acceptance, ointment, spray, liniment or tincture.
Pharmaceutical composition of the present invention has blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian, deep effect of having one's ideas straightened out.To treatment lumbar vertebra hyperosteogeny, prolapse of lumbar intervertebral disc, lumbar muscle strain, the lumbar spondylosis Be very effective such as rheumatism or rheumatoid lumbago, have no side effect.
Experimental example is used for further illustrating the present invention below, but is not limited to the present invention.
One, experimental example
1, clinical observation
Treatment group anthology invention emplastrum (according to the preparation of embodiment 1 method) treatment lumbar vertebra hyperosteogeny, prolapse of lumbar intervertebral disc, lumbar muscle strain, lumbar vertebra patient 100 examples such as rheumatism or rheumatoid lumbago, wherein male 50 example, women 50 example.
Matched group selects a subsides spirit plaster, and the healthy pharmaceutcal corporation, Ltd in effluent north produces, treatment lumbar vertebra hyperosteogeny, prolapse of lumbar intervertebral disc, lumbar muscle strain, lumbar vertebra patient 100 examples such as rheumatism or rheumatoid lumbago, wherein male 50 example, women 50 example.
2, medicament selection
Treatment group: emplastrum of the present invention (according to the preparation of embodiment 1 method), treats three courses for the treatment of (15 days courses for the treatment of), 2 days/paste.
Matched group: one pastes clever plaster, the healthy pharmaceutcal corporation, Ltd in effluent north produces, and treats three courses for the treatment of (15 days courses for the treatment of), 2 days/paste.
3, diagnostic criteria
1. lumbago, lifting in morning, alleviates after activity.Multi-activity or rear lumbago of bearing a heavy burden increase the weight of again, swollen based on acid, uncomfortable
2. many without clear and definite pressure pain point
3. waist limitation of activity
4. waist has tunked comfort sense
5. nerve compression sign is not accompanied
6. X sheet display vertebral body has osteophytosis, stenosis of disc space
4, criterion of therapeutical effect
" in cure the desease Standardization of diagnosis and curative effect " of implementing with reference to State Administration of Traditional Chinese Medicine 1994 drafts as follows:
Recovery from illness: tcm clinical practice symptom, sign disappear or substantially disappear;
Effective: tcm clinical practice symptom, sign obviously change;
Effective: tcm clinical practice symptom, sign all take a favorable turn;
Invalid: tcm clinical practice symptom, sign are all not improved;
5, therapeutic outcome
The Comparison of therapeutic of lumbar spondylosis treated by table 1
6, conclusion
Treatment group and matched group are treated three courses for the treatment of respectively (15 days each courses for the treatment of), and treatment group loses money in a business invention emplastrum (according to the preparation of embodiment 1 method), and matched group pastes clever plaster, the production of effluent northern healthy pharmaceutcal corporation, Ltd.Therapeutic outcome shows, treatment group total effective rate 97% of the present invention, matched group total effective rate 82%.Treatment group of the present invention is obviously better than matched group.
7, discuss
In pharmaceutical composition of the present invention Cornu Cervi be the stag such as Cervus nippon Temminck, Cervus elaphus linnaeus grow up to the young horn ossify.Salty in the mouth, tepor, nontoxic, enter liver, kidney channel.Cure mainly: sore swollen toxin, blood stasis is had a pain, asthenia internal injury, lumbar vertebrae pain.Rhizoma Acori Graminei: pungent, bitter, temperature.GUIXIN, stomach warp.Function removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae." property of medicine opinion ": " wind syndrome of head, under tear, kills parasites for dispelling the wind and dampness pathogens insensitive impediment, tinnitus, controls malignant boil scabies scabies." Pheretima: cold in nature, salty in the mouth.Heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis; Twitch for unconsciousness due to high fever infantile convulsion, joint is benumbed, numb limbs and tense tendons, hemiplegia.Vermilion is the redness of the skin or complexion cinnabar manually made.Inorganic compound, molecular formula Hgs, cherry powder; Pungent, temperature, poisonous.Enter the heart, lung, stomach warp.Function counteracting toxic substances, parasite killing, dampness, robs expectorant.Control scabies malignant boil, eruptive disease cardiac and abdominal pain.Spina Gleditsiae: pungent, temperature.Return liver, stomach warp, evacuation of pus of drawing out pus by applying a plaster to the affected part, promoting blood circulation and detumescence.For carbuncle, sore, pus becomes not burst, scabies.Camphora: pungent, hot, poisonous.GUIXIN, spleen channel.Effect dehumidifying parasite killing, warming and odynolysis, having one's ideas straightened out, it is dirty to ward off.Cure mainly scabies pruritus, traumatic pain.Rhizoma Homalomenae is the dry rhizome that Araeceae puts down silk taro platymiscium Rhizoma Homalomenae Homalomenaocculta (Lour.) Schott.Hardship, pungent, temperature.Return liver, kidney channel.Wind-damp dispelling, strengthening bone and muscle, pain relieving, detumescence.Dispelling the wind and dampness pathogens arthralgia pain, podomere is ached, and muscles and bones flaccidity is soft, stomachache, and carbuncle skin ulcer swells.Rhizoma Drynariae: meridian distribution of property and flavor: bitter, temperature.Return kidney, Liver Channel.Function: the kidney invigorating bone strengthening, continues and hinders pain relieving." book on Chinese herbal medicine is stated ": " control lumbago migratory arthralgia, apoplexy arthroncus of knee contraction gas is demonstrate,proved.Radix Cucubali is root or the herb of pinkwort Brachystemma calycina D. Don..Sweet; Bitter; Property is put down.Enter liver, spleen channel.Effect: blood circulation promoting and blood stasis dispelling; Treating stranguria let out turbid; Removing toxic substances and promoting subsidence of swelling." choosing of Yunnan Chinese herbal medicine ": " eliminating dampness and promoting diuresis, relaxing muscles and tendons to promote blood circulation.Control traumatic injury, fracture.Ramulus Sambuci Williamsii: " book on Chinese herbal medicine newly organized ": " bitter in the mouth, pungent, gas is put down, slightly poisonous." have anti-inflammation, heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation and stopping pain, effects such as synthetism of stimulating the menstrual flow.Tang Materia Medica: " main injured, reuniting the fractured tendons and bones, except pruritus due to wind pathogen, dental caries.Can be bath soup." Rhizoma Paridis has another name called Rhizoma Paridis, is the rhizome of liliaceous plant China Rhizoma Paridis.Nature and flavor: bitter, cool.Mild toxicity GUIXIN warp, Liver Channel, lung meridian, stomach warp, large intestine channel.Function: anticancer, the reducing swelling and alleviating pain of relieving internal heat, heat clearing away arresting convulsion.Herba Lycopodii: sweet, bitter is flat.Return Liver Channel.Inrigorating qi and promoting blood circulation, channels sootheing and network vessel quickening." Jiangxi medical herbs ": dispel the wind dissipating blood stasis.Dispelling the wind and dampness pathogens arthralgia pain, traumatic injury." Hunan medicine will ": relaxing muscles and tendons to promote blood circulation, invigorating qi and dredging collateral.Herba Dendrobii: meridian distribution of property and flavor: be slightly cold; Sweet; Return stomach, kidney channel.Function cures mainly: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Herba Senecionis Scandentis has another name called Herba Hieracii Umbellati, Herba Senecionis Scandentis, Herba Sidae Rhombifoliae, Kowloon light, nine ridge light.Cold in nature, the effects such as bitter in the mouth, has heat-clearing and toxic substances removing, improving eyesight, antipruritic.Be used for anemopyretic cold, conjunctival congestion and swelling pain, dysentery, skin eczema furuncle." Guizhou medical herbs ": heat-clearing and toxic substances removing, expelling wind and removing dampness.Control acute rheumatism arthralgia, innominate toxic swelling.Lignum Sappan is the dry duramen of Caesalpiniaceae Caesalpinia plant Lignum Sappan.Return careful; Liver; Stomach; Large intestine channel." medical center bun is wanted ": reinforcing the heart dissipating blood stasis, except the wind heat of the absurd work of blood system.Radix Cudraniae is Moraceae three-bristle cudrania platymiscium cudrania cochinchinensis Cudrania cochin chinensis (Lour.) Kudo et Masam., is used as medicine with root.Micro-hardship, flat." book on Chinese herbal medicine asks former ": strengthening bone and muscle, invigorates blood circulation, reason traumatic injury.Be used as medicine with root, lightly seasoned micro-hardship, cool in nature, there is good anti-tubercle bacillus effect.Moschus: be the secretions of the glandular sac between the umbilicus of male Moschus moschiferous and genitals, in graininess or bulk after dry.Pungent, temperature, GUIXIN, spleen channel.Function cures mainly: refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, pain relieving." Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House ": the logical pancreas reason of sun can be changed.Can thoroughly reach by priming." detailed outline ": logical all keys, opens meridians, saturating flesh bone.Carapax et Plastrum Testudinis is sternite and the carapace of Testudinidae animal chinemys reevesii.Salty in the mouth is flat.Enter Liver and kidney warp.Effect YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, strong bone.Herba Calthae Membranaceae: nature and flavor: bitter, acrid, cold.Gui Jing: return liver,spleen,kidney warp.Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling." Traditional Chinese Medicine in Sichuan will ": expelling wind and cold.Control cough due to lung-heat, disappear goiter, is coated with carbuncle pyogenic infections from tumour or sore, helps digestion long-pending glutted.The Radix Euphorbiae Pekinensis: nature and flavor: bitter, cold.Poisonous.Enter lung, spleen, kidney channel.Function cures mainly: removing water retention by purgation Shen, and profit two just.Harness the river swollen, dropsy, phlegm retention, scrofula, swollen ulcer drug.Eupolyphaga Seu Steleophaga: its cold in nature, salty in the mouth, poisonous, can enter conscience spleen three warp, the effect such as have removing blood stasis, removing mass, dredging collateral, reason wound and reunion of bone, reducing swelling and alleviating pain, stimulating milk secretion are stimulated the menstrual flow, be treating blood disorders traumatology key medicine." longevity generation is newly organized ": control traumatic injury, blood stasis is made a psychological attack.Radix Psammosilenes is Caryophyllaceae Radix Psammosilenes platymiscium Radix Psammosilenes, is used as medicine with root.Autumn and winter uproot, and scrape off crust, dry for subsequent use.Pungent, temperature.Poisonous.Function cures mainly: expelling wind and activating blood circulation, eliminating stasis to stop pain.For traumatic injury, rheumatalgia, stomachache; Wound hemorrhage is controlled in external." Yunnan Chinese herbal medicine ": " hemostasis and pain-relieving, blood circulation promoting and blood stasis dispelling.Except rheumatism.Cornu Bubali: Kucheng, cold.Enter the heart, liver, spleen, stomach four warp.Heat clearing away, removing heat from blood, removing toxic substances.Cure the wound the cold pestilence pathogenic heat attacking blood system in febrile diseases, mania and irritation, irritated, delirium, macule, and jaundice is spitted blood, epistaxis, hematochezia, swollen ulcer drug.Rhizoma Dioscoreae Septemlobae: property is put down, bitter in the mouth.Enter Liver Channel, stomach warp, urinary bladder channel.Function: dampness removing goes turbid, dispel the wind blood stasis dispelling.Dampness removing goes turbid, wind expelling stagnation removing., " herbal classic ": main lumbago and backache, bone strengthening save, wind and cold wetted perimeter numbness, malignant boil is recover not, steam.Rhizoma Kaempferiae: pungent, temperature.Return stomach warp.Circulation of qi promoting warming middle-JIAO, helps digestion, pain relieving, rheumatic arthritis, traumatic injury.Herba Artemisiae Anomalae: nature and flavor with return through: bitter in the mouth, flat.Return liver, gallbladder meridian.Function with cure mainly: dampness removing jaundice eliminating, heat-clearing and toxic substances removing, promoting blood circulation and detumescence." Fujian traditional herbal medicine ": invigorate blood circulation, removing blood stasis with potent drugs, detumescence, removing toxic substances.Pyritum (calcined): pungent is flat.There is eliminating stasis to stop pain, effect of reunion of fractured tendons and bones.For treating swelling and pain by traumatic injury, injured bone." beautiful Chinese catalpa medicine solution ": removing blood stasis disappears wart, treats the genus of rheumatism paralysis, the power of removing dampness, with pyrolusitum together.All medicines merge, and pharmaceutical composition of the present invention has blood circulation promoting and blood stasis dispelling, promoting the flow of QI in the collateral by warming the meridian, deep effect of having one's ideas straightened out.To treatment lumbar vertebra hyperosteogeny, prolapse of lumbar intervertebral disc, lumbar muscle strain, the lumbar spondylosis Be very effective such as rheumatism or rheumatoid lumbago, have no side effect.
Experimental example two, model case
Case 1: grandson, man, 55 years old.Because overwork, add and suffer from cold, start pain in the lumbar region, do not note, just think it is tired, just it is in many rests, also can relieve the pain or medicine with some plaster once in a while, but the state of an illness is more and more serious, walk, bend over, stand up and all occurred pain, deny Other diseases history.The dark yellow fur of tongue, slippery and rapid pulse.Be diagnosed as lumbar vertebra hyperosteogeny.By the invention plaster that loses money in a business (according to the preparation of embodiment 1 method) treatment two courses for the treatment of (15 days each courses for the treatment of), patient is conscious, and flank pain sense obviously alleviates.After continuing to strengthen a course for the treatment of, CT review result lumbar vertebra sequence is normal, and symptom disappears completely.
Case 2: Lee, man, 50 years old, in more than ten years of patient's lumbago, once film making belonged to waist 1,2,3,4 hyperosteogeny, and through taking medicine, physical therapy etc. slightly take a turn for the better, and drug withdrawal again repeatedly, more bitterly consequently can not be worked for nearly 1 year.Clinical manifestation: lumbar vertebra pain, increases the weight of when standing up, movable alleviation, and times of defecation increases, and dream is many, heart beating, and light red tongue is dark, and tongue is white, thin fur, floating pulse, stringy pulse, tense pulse; Diagnosis: lumbar vertebra hyperosteogeny.The application of the invention ointment (according to the preparation of embodiment 2 method) treatment three courses for the treatment of (15 days each courses for the treatment of), lumbar vertebra pain, disappears, and remaining symptom also mitigates.During further consultation, tongue arteries and veins is the same.Cure completely after continuing to strengthen a course for the treatment of.
Case 3: Zhang, female, 48 years old.Because suffering from cold, pain in the lumbar region, not in attention, just thinking suffers from cold causes, and just it is in many rests, used plaster to relieve the pain, but the state of an illness is more and more serious, walks, bend over, stand up and all occurred pain, deny Other diseases history.The dark yellow fur of tongue, slippery and rapid pulse.Be diagnosed as lumbar vertebra hyperosteogeny.The application of the invention spray (according to the preparation of an embodiment 3 method) treatment course for the treatment of (15 days each courses for the treatment of), patient is conscious, and flank pain sense obviously alleviates.After continuing a course for the treatment of of use, CT review result lumbar vertebra sequence is normal, and symptom disappears completely.
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1 emplastrum
By said medicine conveniently technique add customary adjuvant and make emplastrum, 2 days/paste.
Embodiment 2 ointment
By said medicine conveniently technique add customary adjuvant and make ointment.
Embodiment 3 spray
By said medicine conveniently technique add customary adjuvant and make spray.
Embodiment 4 liniment
By said medicine conveniently technique add customary adjuvant and make liniment.
Embodiment 5 tincture
By said medicine conveniently technique add customary adjuvant and make tincture.
Claims (6)
1. treat a pharmaceutical composition for lumbar spondylosis, it is characterized in that, the crude drug of said composition consists of:
2. pharmaceutical composition as claimed in claim 1, it is characterized in that, the crude drug of this pharmaceutical composition consists of:
3. pharmaceutical composition as claimed in claim 1, it is characterized in that, the crude drug of this pharmaceutical composition consists of:
4. the pharmaceutical composition as described in one of claim 1-3, it is characterized in that this pharmaceutical composition conveniently technique add customary adjuvant and make the emplastrum of clinical acceptance, ointment, spray, liniment or tincture.
5. the application of the pharmaceutical composition as described in one of claim 1-3 in the medicine of preparation treatment lumbar spondylosis.
6. application as claimed in claim 5, is characterized in that described lumbar spondylosis refers to lumbar vertebra hyperosteogeny, prolapse of lumbar intervertebral disc, lumbar muscle strain, rheumatism or rheumatoid lumbago.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1994430A (en) * | 2007-01-09 | 2007-07-11 | 北京市门头沟区中医医院 | Externally applied ointment for activating blood circulation and unblocking obstruction |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1994430A (en) * | 2007-01-09 | 2007-07-11 | 北京市门头沟区中医医院 | Externally applied ointment for activating blood circulation and unblocking obstruction |
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