CN102764355A - Traditional Chinese medicine composite for curing femoral head necrosis - Google Patents
Traditional Chinese medicine composite for curing femoral head necrosis Download PDFInfo
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- CN102764355A CN102764355A CN2012102871883A CN201210287188A CN102764355A CN 102764355 A CN102764355 A CN 102764355A CN 2012102871883 A CN2012102871883 A CN 2012102871883A CN 201210287188 A CN201210287188 A CN 201210287188A CN 102764355 A CN102764355 A CN 102764355A
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Abstract
The invention discloses a traditional Chinese medicine composite for curing femoral head necrosis, and relates to the technical field of Chinese herbal medicine. The traditional Chinese medicine composite is characterized by composing, by weight, 40 parts to 60 parts of angelica, 30parts to 50 parts of ligusticum chuanxiong hort, 30 parts to 50 parts of rehmannia glutinosa, 30 parts to 50 parts of red peony, 20 parts to 40 parts of prepared frankincense, 20 parts to 40 parts of prepared myrrh, 20 parts to 40 parts of fructus psoraleae, 20 parts to 40 parts of rhizoma drynariae, 30 parts to 50 parts of desertliving cistanche, 20 pars to 40 parts of herba epimedii, 20 pars to 40 parts of ground beetles, 15 parts to 25 parts of scorpion, 10 pars to 20 parts of saffron, 20 pars to 40 parts of dragon blood and 20 pars to 40 parts of deer-horn glue. The traditional Chinese medicine composite for curing femoral head necrosis can promote blood circulation and remove blood stasis, strengthen muscles and bones, remove necrotic tissues and promote tissue regeneration, effectively cure femoral head necrosis, and enable patients to regain motor functions.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of Chinese medicine composition that is used to treat femur head necrosis.
Background technology
Femur head necrosis is claimed ischemic necrosis of femoral head again, is one of common osteoarthritis.Because of illness such as rheumatism, hematopathy, bends, burn cause, destroy the blood supply of adjacent joints covering weave earlier, and then cause necrosis mostly.Its cardinal symptom develops into rest pain gradually from discontinuity pain, again by pain cause muscle spasm, joint motion is restricted, cause seriously at last and disable.Hormone drug also can cause the generation of primary disease, and the traditional Chinese medical science thinks that the disease occurrence cause is exopathogenic factor and endogenous cause of ill, and the endogenous cause of ill exopathogenic factor interacts, and makes the human body disequilibrium, and QI and blood unbalance and give birth to disease also claimed " rheumatism involving the bone ", " bone withers ".
Summary of the invention
Technical problem to be solved by this invention be to provide a kind of can blood circulation promoting and blood stasis dispelling, bone and muscle strengthening, the Chinese medicine composition that is used to treat femur head necrosis of putrefaction removing and tissue regeneration promoting.
Technical problem to be solved by this invention adopts following technical scheme to realize:
A kind of Chinese medicine composition that is used to treat femur head necrosis is characterized in that: described compositions is made up of the component of following weight,
Radix Angelicae Sinensis 40-60 part, Rhizoma Chuanxiong 30-50 part, Radix Rehmanniae Preparata 30-50 part, Radix Paeoniae Rubra 30-50 part, Olibanum (processed) 20-40 part, Myrrha (processed) 20-40 part, Fructus Psoraleae 20-40 part, Rhizoma Drynariae 20-40 part, Herba Cistanches 30-50 part, Herba Epimedii 20-40 part, eupolyphaga 20-40 part, Scorpio 15-25 part, Squama Manis 10-20 part, Stigma Croci 10-20 part, Sanguis Draxonis 20-40 part, Colla cornus cervi 20-40 part.
The optimum weight of each component does,
50 parts of Radix Angelicae Sinensis, 40 parts of Rhizoma Chuanxiongs, 40 parts in Radix Rehmanniae Preparata, 40 parts of Radix Paeoniae Rubra, 30 parts of Olibanum (processed)s, 30 parts of Myrrha (processed)s, 30 parts of Fructus Psoraleaes, 30 parts of Rhizoma Drynariae, 40 parts of Herba Cistanches, 30 parts of Herba Epimedii, 30 parts of eupolyphaga, 20 parts of Scorpio, 15 parts of Squama Maniss, 15 parts of Stigma Crocis, 30 parts of Sanguis Draxonis, 30 parts of Colla cornus cervis.
Pharmaceutical analysis
Radix Angelicae Sinensis:
[property of medicine] is sweet, hot, warm.Return liver, the heart, spleen channel.
[effect] tonifying blood and regulating menstruation, promoting blood circulation and stopping pain, loosening bowel to relieve constipation.
The sweet Wen Zhirun of [pharmacological action] these article is blood circulation promoting competent silt, enrich blood invigorate blood circulation, cold expelling hemostasis.
Rhizoma Chuanxiong:
[property of medicine] suffering, temperature.Return liver, gallbladder, pericardium channel.
[effect] blood-activating and qi-promoting, wind-expelling pain-stopping.
[pharmacological action] Rhizoma Chuanxiong can be expanded blood vessel, microcirculation improvement; Can reduce surface activity of blood platelet, suppress platelet aggregation, the formation of prevention thrombosis.The abirritative effect is arranged, and obvious and persistent hypotensive effect is arranged; Can quicken the to fracture absorption of local hematoma promotes the formation of callus; Can suppress various bacteria.
Radix Rehmanniae Preparata:
[property of medicine] is sweet, tepor.Return the Liver and kidney warp.
[effect] yin nourishing of enriching blood, life essence-filling, marrow-benefitting.
The nourish blood key medicine of tonify deficiency of [pharmacological action] this grade.
Radix Paeoniae Rubra:
[property of medicine] hardship is slightly cold.Return Liver Channel.
[effect] clearing away heat and cooling blood, eliminating stasis to stop pain.
[pharmacological action] spasmolysis; To the slightly effect of blood vessel dilating of blood circulation; Analgesia, calm, anticonvulsant action; Antiinflammatory, antiulcer action; Antibiotic, refrigeration function.
Olibanum (processed):
[property of medicine] is arduous, temperature.After one's own heart, liver, spleen channel.
[effect] blood-activating and qi-promoting; Inducing menstruation to relieve menalgia; Detumescence and promoting granulation.
[pharmacological action] main trusted subordinate's pain; Rheumatic arthralgia; The amenorrhea dysmenorrhea; The traumatic injury stasis of blood is logical; Swollen ulcer drug; The intestinal carbuncle; The sore being festered and unhealed.
Myrrha (processed):
[property of medicine] is hot, bitter, and is flat.GUIXIN, liver, spleen channel.
[effect] promoting blood circulation and stopping pain, detumescence and promoting granulation.
The effect of [pharmacological action] Myrrha cures mainly similar with Olibanum, the relatively diffusing blood blood stasis dispelling of Myrrha; Olibanum is partial to circulation of qi promoting, is stretched muscle.
Fructus Psoraleae:
[property of medicine] acrid in the mouth, hardship, warm in nature.Return kidney, pericardium, spleen, stomach, lung meridian.
[effect] reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.
[pharmacological action] is used for insufficiency of kidney-YANG, decline of the fire from the gate of life, chills and pain of the waist and kness.
Rhizoma Drynariae:
[property of medicine] hardship, temperature.Return kidney, Liver Channel.
[effect] the kidney invigorating bone strengthening continues and hinders pain relieving.
[pharmacological action] is used for lumbago due to renal deficiency, Hiccough and deaf, and odontoseisis, falling winks frustrates, and the muscles and bones folding is hindered.
Herba Cistanches:
[property of medicine] sweet acid is salty, temperature.Go into kidney, large intestine, spleen, liver, urinary bladder channel.
[effect] reinforcing the kidney and supporting YANG, loosening bowel to relieve constipation, hard masses softening and resolving.
[pharmacological action] is used for insufficiency of kidney-YANG, and through the empty soreness of the waist and knees of anemia, muscles and bones is unable; The ability kidney-replenishing, benefiting essence-blood, warm waist knee joint.
Scorpio:
[property of medicine] is hot, flat, poisonous.Return Liver Channel.
[effect] spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain.
[pharmacological action] is used for rheumatoid arthritis stubborn, is good at removing obstruction in the collateral to relieve pain, to the anemofrigid-damp arthralgia obstinate, and the contracture of muscle arteries and veins, even the insensitive impediment effect of joint deformity is rather good; Other is used to the spasm of twitching, and can calm down liver-wind, and expel wind to dredge collateral is to convulsion again.
Eupolyphaga:
[property of medicine] is salty, and is cold; Slightly poisonous.Return Liver Channel.
[effect] removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.
[pharmacological action] is used for the muscles and bones folding and hinders blood stasis amenorrhea, lump in the abdomen mass in the abdomen.
Herba Epimedii:
[property of medicine] is hot, sweet, temperature.Return liver, kidney channel.
[effect] kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.
[pharmacological action] is used for impotence due to deficiency of the kidney, seminal emission premature ejaculation, soft, the cold extremities with aversion to cold of waist knee joint flaccidity; Arthralgia due to cold-dampnes or spasm of the limbs are numb.The dispelling the wind and dampness pathogens arthralgia pain is partial to cold-damp person, and numb limbs and tense tendons or muscles and bones contracture etc.
Squama Manis:
[property of medicine] is salty, is slightly cold.Return liver, stomach warp.
[effect] promoting blood circulation to restore menstrual flow, detumescence and apocenosis.
[pharmacological action] is used for amenorrhea due to stagnation of blood, lump in the abdomen caking, diseases such as rheumatic arthralgia, the contracture of muscle arteries and veins.Squama Manis is good at walking to scurry, and property specially row is loose, ability promoting blood circulation to remove blood stasis, current meridians.
Stigma Croci:
[property of medicine] is hot, warm.GUIXIN, Liver Channel.
[effect] promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.
[pharmacological action] promotes the huge function of biting of cell, strengthens the immunologic function of cell, strengthening body resistance; Promote blood of human body circulation blood oxygen supply; Enhancing body endurance strengthens lymphproliferation response, improves body cell immunity and humoral immunization with this; Play the operation of adjustment human functional activity of vital energy, the effect of balance human body negative and positive.
Sanguis Draxonis:
[property of medicine] is sweet salty, and is flat.Go into the heart, liver, spleen channel.
[effect] taken promoting blood circulation to remove blood stasis orally, analgesic therapy, and the external hemostasia and promoting granulation is held back skin ulcer.
[pharmacological action] antifungic action; Antiinflammatory action; To hemorheological property and to the influence of platelet aggregation.
Colla cornus cervi:
[property of medicine] is sweet salty, temperature.Go into liver, kidney channel.
[effect] enriches blood, and benefit is smart.
[pharmacological action] is to the influence of hemocyte: can promote erythrocyte, leukocyte, hematoblastic amount in the peripheral blood to increase; To progressive muscular dystrophy disease, significant control and therapeutical effect are arranged; Promote the absorption and the intravital retention of calcium, make that calcium slightly improves in the blood, can reduce capillary permeability, make and ooze out minimizing, antiinflammatory, detumescence and anti-allergic effects are arranged.
Usage and dosage:
Each flavor medicine is ground and is smalls, and mix homogeneously adds Mel 300g, is combined into ball.Each clothes 6g, three times on the one, I-II option share bone bland necrosis, the half a year course of treatment, clinical cure; III option share bone bland necrosis, 1 year course of treatment, clinical cure.
Complementary therapy:
1. skin traction of lower extremity
2. functional exercise
3. avoid tobacco and wine
4. base stage is treated protopathy.
The invention has the beneficial effects as follows: the present invention can blood circulation promoting and blood stasis dispelling, bone and muscle strengthening, and putrefaction removing and tissue regeneration promoting can effectively be cured femur head necrosis, makes the patient recover motor function.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach purpose and effect and be easy to understand and understand, below in conjunction with specific embodiment, further set forth the present invention.
Embodiment 1
Radix Angelicae Sinensis 50g, Rhizoma Chuanxiong 40g, Radix Rehmanniae Preparata 40g, Radix Paeoniae Rubra 40g, Olibanum (processed) 30g, Myrrha (processed) 30g, Fructus Psoraleae 30g, Rhizoma Drynariae 30g, Herba Cistanches 40g, Herba Epimedii 30g, eupolyphaga 30g, Scorpio 20g, Squama Manis 15g, Stigma Croci 15g, Sanguis Draxonis 30g, Colla cornus cervi 30g.
Each flavor medicine is ground and is smalls, and mix homogeneously adds Mel 300g, is combined into ball.Each clothes 6g, three times on the one.
Embodiment 2
50 years old worker of Utilities Electric Co. of Cui Yu post man in December, 2011 is gone to a doctor because of " right hip pain 2 years increases the weight of February ".Under the no obvious inducement, conscious right hip pain is uncomfortable, and is obvious when bending and stretching activity, do not influence operate as normal and life, do not give attention at that time, do not do special handling before 2 years for the patient.The patient goes out to handle affairs by bike before February, and the back right hip pain of sense of going home increases the weight of, can not on lift, have a rest and do not see and alleviate; Then right carrying out property of hip pain increases the weight of, and walks lamely me institute to go to a doctor, and looks into: the hip joint limited range of motion; Be limited as very with anteflexion, all tenderness (+) of hip, local skin is not seen obvious redness, heating; The hip in the wrong test (+) of going down on one's knees, 4 words tests (+), left side (-).Taking the photograph DR shows: right lateral thigh bone cortical bone seriality is interrupted, bland necrosis (in early days).Plan is accepted for medical treatment with " right coxitis ".
While in hospital is given right hip pin cutter lysis, cooperates the fluid infusion of Chinese medicine and western medicine antiinflammatory, invigorating the liver and kidney, bone and muscle strengthening, removing obstruction in the collateral to relieve pain anti symptom treatment, gives the present invention when leaving hospital and grinds and be the end, adds Mel 300g, is combined into ball.Each clothes 6g, three times on the one.And advise its crutch to assist row, suitably functional exercise.
Patient's function limitation obviously improves after 3 months, takes the photograph sheet and shows: right lateral thigh bone cortical bone density reduces than offside, and the part cortical bone is interrupted.Continue to take medicine after half a year, the right hip joint walking of patient, the activity of bending and stretching normally do not have untoward reaction such as obvious red and swollen heat pain, and take the photograph sheet and show: right lateral thigh bone is on the throne, and cortical density is normal.
Embodiment 3
31 years old migrant worker of Peng Yu great waves men in August, 2011 is because of " right hip pain, limitation of activity surplus half a year "
Go to a doctor.Patient's cause half a year is fallen accidentally and is caused right hip pain, and movable unfavorable, the outpatient service of second the People's Hospital is sought medical advice in the Jieshou City, be diagnosed as " soft tissue injury " and advise it to lie up, after slightly alleviate, but right hip pain symptom is arranged always.Recently it is obviously limited to feel the right lower extremity activity, influences orthobiosis and work.Today institute of traditional Chinese medicine takes the photograph DR and shows in the Fuyang City Taihe County: right femur head necrosis.The suggestion hospitalization, the patient satisfies and comes me institute to seek medical advice, and requires hospitalization, and outpatient service is intended and is accepted for medical treatment and be admitted to hospital with " right femur head necrosis ".
Right hip joint activity is obviously limited, all popularity tenderness of right hip, and local skin is not seen obvious heating, swelling.The horizontal position right lower extremity can not independently stretch, deficiency in length, and the huckle amyotrophy, color and luster is dark slightly, the hip of going down on one's knees test (++), 4 words tests (++), muscular strength level Four.Taking the photograph right hip DR shows: right femoral head profile is imperfect, femur head necrosis.
While in hospital gives local pin cutter lysis, functional exercise, joint immobilization, massage physical therapy, electrical excitation treatment, Chinese medicine and western medicine invigorating the liver and kidney, bone and muscle strengthening, removing obstruction in the collateral to relieve pain, blood circulation promoting and blood stasis dispelling, benefit bone and keeps fit anti symptom treatment.Give the present invention and grind and be the end, add Mel 300g, be combined into ball.Each clothes 8g, three times on the one.
The right hip of patient does not have pain after 1 month, and bending and stretching does not movablely have limitedly basically, and the huckle amyotrophy obviously alleviates, and color and luster is ruddy, takes the photograph DR and shows: on the right femoral head angle scarce as, all the other position cortex are partly interrupted.After continuing to take medicine 8 months, patient's normal activity is not limited, takes the photograph sheet and shows: on the right lateral thigh bone angle in the form of sheets, the cloud shade.
Embodiment 4
Appoint gram to be engaged in agriculture in November, 2009 in big male 41 years old because of " left hip pain, limitation of activity surplus January " prescription on individual diagnosis.The patient does not have under the obvious inducement, right hip pain occurs, the abduction limitation of activity; Thought at that time and then do not give attention due to the fatigue, during the conscious right hip pain of patient, carrying out property of limitation of activity increase the weight of; Come my gate to examine and seek medical advice, look into the pelvis plain film and show: bilateral femoral head is downright bad, with the left side for very.Plan is accepted for medical treatment and is admitted to hospital with " bilateral femoral head is downright bad ".Have a medical check-up: the double hip joint limitation of activity, left hip joint valgus deformity, all popularity tenderness of right hip, local skin is not seen obvious heating, swelling.The horizontal position left lower extremity can not independently stretch, deficiency in length, and the amyotrophy of bilateral huckle, color and luster is dark slightly, the hip of going down on one's knees test (++), 4 words tests (++), muscular strength level Four.DR shows: left side femoral head cortex seriality is interrupted, collapse of the femoral head; Right lateral thigh bone density unevenness, irregular sclerosis.The prompting bilateral femoral head is downright bad, with the left side for very.
While in hospital give double hip joint before, outer, rear side pin cutter lysis, and the schemes such as massage physical therapy, herbal fumigation, Chinese and western drugs blood circulation promoting and blood stasis dispelling, invigorating the liver and kidney, bone and muscle strengthening, removing obstruction in the collateral to relieve pain, blood circulation promoting and blood stasis dispelling of giving handle, improvement is left hospital.Still have left side hip joint limitation of activity when leaving hospital.Give the present invention and grind and be the end, add Mel 300g, be combined into ball.Each clothes 8g, three times on the one.
Follow up a case by regular visits to after 1 month, the pain relief of patient's double hip joint, the activity of bending and stretching still has acid precipitation, and is heavier because of patient's symptom, wouldn't give check DR, advises it to continue to take medicine, the auxilliary row of crutch, functional exercise is handled; Patient's double hip joint mobility of taking medicine after half a year is normal basically, and it is slightly limited that the hip activity of going down on one's knees is bent in the left side, and take the photograph two hip DR and show: right lateral thigh bone has the cloud shade, and area is less; The left side collapse of the femoral head, profile is imperfect, and the cryptomere shadow region is arranged; Check DR shows after taking medicine 1 year: right femoral head cortical bone is continuous, does not see obvious interruption; Left side femoral head profile is imperfect, lacks like courseware cloud heart osteogenic tissue district, edge, position.
Embodiment 5
17 years old student of Zhou Ziqiang man is because of " two lower limb pains 8 years are surplus, because of cold weather increases the weight of January." go to a doctor.The patient is no obvious inducement appearance before 8 years, two lower limb pains.Went to a doctor once during this period in how tame hospital, and originally with sacroiliitis, treated, the treatment back takes a turn for the better.Above-mentioned symptom is heavy when light during this period the time, and because of father and mother do manual work outside, the upright hospital admission in the Shanxi Province is examined and is " ankylosing spondylitis " before 2 years.Nearly 2 years are oral always, medicine symptomatic treatments such as sulfasalazine, diclofenac, Radix Paeoniae Alba total glucosides, and closely over the sky in January, because of the two lower limb pains of cold weather increase the weight of, to walk the back obviously, oral once more above medicine loses alleviation especially.Modern is further to treat to satisfy my institute's prescription on individual diagnosis, and outpatient service with " ankylosing spondylitis " income in hospital.Patient in the course of disease, expression is painful, walks lamely during walking, needs the household to assist in, diet, sleep still can, large and small just normal, body weight does not have significant change.
Have a medical check-up: walk lamely during the left lower extremity walking, by the vertebral body of a L5-S1 left side, tunk pain (++); Left vertical leg is raised test (++), right straight-leg raising test (+), two sacroiliac joint squeeze tests (+); A left side " 4 " word test (++), right " 4 " word test (+), left knee jerk is hyperfunction; The left lower extremity muscular strength goes down, surplus no abnormality seen.The pelvis plain film shows: sacroiliitis sexually revises, and pelvis CT shows: fl skull matter changes, bland necrosis.
After being admitted to hospital, the patient gives spinal column and two hip pin cutter treatment and the fluid infusion of Chinese medicine and western medicine antiinflammatory, invigorating the liver and kidney, bone and muscle strengthening, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain anti symptom treatment.Vertebral part pain, limitation of activity are alleviated basically when leaving hospital, and it is limited that left hip joint bends and stretches movable part, do not have obvious tenderness.Give the present invention and grind and be the end, add Mel 300g, be combined into ball.Each clothes 8g, three times on the one.And cooperate the auxilliary row of crutch, avoid bearing a heavy burden lower limb traction, functional exercise auxiliary treatment.
Check after half a year, patient's spinal column and right hip do not have malaise symptoms such as pain, limitation of activity, and left hip joint does not have tenderness, and the activity of bending and stretching is slightly limited, no tenderness, and " 4 " word test (+), muscular strength is normal.Taking the photograph DR shows: the left side femoral head is seen the cloud area of new bone, and the part bone trabecula connects imperfect; Continue to take medicine and auxiliary treatment, check after 1 year, the patient goes to turn and can normally walk, mobility still can, abnormal responses such as no red and swollen heat pain, check DR shows: right femoral head cortex is continuous, bone trabecula arrangement is orderly, complete; Continuing to take medicine heightens the effect of a treatment half a year, follows up a case by regular visits to symptom after 1 year and does not have recurrence.
More than show and described ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; The present invention is not restricted to the described embodiments; That describes in the foregoing description and the description just explains principle of the present invention; Under the prerequisite that does not break away from spirit and scope of the invention, the present invention also has various changes and modifications, and these variations and improvement all fall in the scope of the invention that requires protection.The present invention requires protection domain to be defined by appending claims and equivalent thereof.
Claims (2)
1. Chinese medicine composition that is used to treat femur head necrosis, it is characterized in that: described compositions is made up of the component of following weight,
Radix Angelicae Sinensis 40-60 part, Rhizoma Chuanxiong 30-50 part, Radix Rehmanniae Preparata 30-50 part, Radix Paeoniae Rubra 30-50 part, Olibanum (processed) 20-40 part, Myrrha (processed) 20-40 part, Fructus Psoraleae 20-40 part, Rhizoma Drynariae 20-40 part, Herba Cistanches 30-50 part, Herba Epimedii 20-40 part, eupolyphaga 20-40 part, Scorpio 15-25 part, Squama Manis 10-20 part, Stigma Croci 10-20 part, Sanguis Draxonis 20-40 part, Colla cornus cervi 20-40 part.
2. a kind of Chinese medicine composition that is used to treat femur head necrosis according to claim 1 is characterized in that: the optimum weight of said each component does,
50 parts of Radix Angelicae Sinensis, 40 parts of Rhizoma Chuanxiongs, 40 parts in Radix Rehmanniae Preparata, 40 parts of Radix Paeoniae Rubra, 30 parts of Olibanum (processed)s, 30 parts of Myrrha (processed)s, 30 parts of Fructus Psoraleaes, 30 parts of Rhizoma Drynariae, 40 parts of Herba Cistanches, 30 parts of Herba Epimedii, 30 parts of eupolyphaga, 20 parts of Scorpio, 15 parts of Squama Maniss, 15 parts of Stigma Crocis, 30 parts of Sanguis Draxonis, 30 parts of Colla cornus cervis.
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CN106620110A (en) * | 2017-02-20 | 2017-05-10 | 卢异奇 | Medicinal liquor for treating bone diseases |
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CN103550456A (en) * | 2013-11-22 | 2014-02-05 | 简厚奎 | Drug for treating bone diseases |
CN106620110A (en) * | 2017-02-20 | 2017-05-10 | 卢异奇 | Medicinal liquor for treating bone diseases |
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