CN101590159B - External medicament for treating ankylosing spondylitis and proliferative arthritis and processing method thereof - Google Patents
External medicament for treating ankylosing spondylitis and proliferative arthritis and processing method thereof Download PDFInfo
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Abstract
The invention discloses an external medicament for treating ankylosing spondylitis and proliferative arthritis, which is processed from the following raw materials in portion by weight: 25 to 35 portions of giant knotweed, 25 to 35 portions of schefflera arboricola, 10 to 30 portions of unprocessed radix aconiti, 30 to 50 portions of radix sileris, 10 to 30 portions of unprocessed radix aconiti carmichaeli, 20 to 40 portions of ligusticum chuanqiong hort, 20 to 50 portions of brassica alba boiss, 10 to 20 portions of herba ephedrae, 5 to 20 portions of saffron, 15 to 35 portions of multibanded krait, 20 to 50 portions of phellodendron amurense, 10 to 30 portions of squama manis, 10 to 20 portions of panax notoginseng, 10 to 20 portions of scorpion, 20 to 40 portions of dittany bark, and 20 to 40 portions of rheum palmatum. The raw materials are used together so that the external medicament has the efficacies of warming meridians and dissolving stasis, warming cold-damp, restoring menstrual flow and removing meridian obstructions, promoting blood circulation and stopping pain, removing stasis and eliminating stagnation, and tonifying kidney and strengthening backbones, can be used for treating ankylosing spondylitis and proliferative arthritis, has the efficacies of repairing and regenerating the damages and the necrosis of bone substances, and can obtain ideal curative effect in a short time.
Description
Technical field:
The present invention relates to a kind of medicine for external use, particularly relate to a kind of medicine for external use and processing method thereof for the treatment of ankylosing spondylitis, rheumatoid arthritis, belong to field of traditional Chinese.
Background technology:
Ankylosing spondylitis is that clinical manifestation is a lumbus sacrum pain based on the whole body property disease of sacroiliac joint and spinal column chronic inflammatory disease, morning deadlock, lumbar vertebra all directions limitation of activity etc.The characteristics of lumbus sacrum pain are that improve movable back, can not alleviate after the rest, and pain when the patient often shows nighttime sleep, even pain is waken up the influence sleep.Morning, stiff stiff sense for the back, back of getting up morning was alleviated after the activity.Generally by upwards development of sacroiliac joint, part patient can involve the whole spinal column that comprises cervical vertebra to pathological changes.Also often with the pain of attachment points such as heel, crista iliaca, rib breast joint, part patient joint of the lower extremity such as hip, knee joint, ankle can occur and swell and ache ankylosing spondylitis, and idol has the inflammation in joints such as shoulder, wrist.The traditional Chinese medical science is thought the cause of disease and the natural endowment deficiency of ankylosing spondylitis, and kidney qi is lost empty, the damp and hot pathogen of affection of exogenous wind-cold, and eating and drinking without temperances etc. are all multifactor relevant.When the course of disease with the passing of time, the pathogen impatency, hematogenous blockage has more the symptom of existing blood stasis, clinical common cold-dampness numbness, damp and hot numbness resistance, kidney qi is lost empty, the obstruction of collaterals by blood stasis syndrome.
Rheumatoid arthritis be a kind of be the chronic general autoimmunity autoimmune disease of feature with the articular synovitis, it is the chronic systemic inflammatory disease that a kind of cause of disease is not understood as yet, with pathological changes outside chronic, symmetry, many synovial jointss inflammation and the joint is main clinical manifestation, belongs to the autoimmune inflammatory diseases.This disease is sent out well in little joints such as hands, wrist, foots, and outbreak is symmetrical distribution repeatedly.Joint red and swollen heat pain and dysfunction are arranged in early days, and late period, stiff deformity in various degree can appear in the joint, and with bone and skeletal muscle atrophy, very easily disabled.From the angle of pathological change, rheumatoid arthritis is a kind of synovium of joint (can feed through to articular cartilage, osseous tissue, articular ligament and flesh key later on) that mainly involves, and is the popularity diseases associated with inflammation of connective tissues such as serous coat, the heart, lung and eye secondly.The general performance of rheumatoid arthritis also has heating, fatigue and weak, pericarditis, subcutaneous nodule, pleuritis, arteritis, peripheral neuropathy etc. except that arthropathy.
The traditional Chinese medical science such as ankylosing spondylitis and rheumatoid arthritis arthromyodynia can have a strong impact on human quality of life, bring heavier burden for family and society, so its study on prevention has become one of problem of World Health Organization's research.At present, domestic and international treatment for rheumatic arthritis and ankylosing spondylitis rests on the Western medicine bases such as non-steroidal drug, antigout drug and steroidal class anti inflammatory immunity medicine mostly.Because the toxic and side effects and the range of application of this class Western medicine are limit, thereby make rheumatoid arthritis, ankylosing spondylitis not be effectively controlled.Facts have proved that motherland's medicine and pharmacology are accumulating rich experience aspect treatment rheumatoid arthritis, the ankylosing spondylitis disease, the traditional Chinese medical science is more emphasized whole treatment, and treating both the principal and secondary aspects of a disease puts prevention first, and untoward reaction is few.Therefore, a kind of this sick new medicine compound preparation for the treatment of of development is highly significant with necessity.
Summary of the invention:
Technical problem to be solved by this invention is: pure Chinese medicinal preparation that a kind of curative effect for the treatment of rheumatoid arthritis, ankylosing spondylitis gives prominence to, has no side effect and preparation method thereof is provided.
The technical scheme that the present invention is taked for the technical solution problem is:
A kind of medicine for external use for the treatment of ankylosing spondylitis, rheumatoid arthritis, process by the following raw materials that with the weight portion is unit: 25～35 parts of Rhizoma Polygoni Cuspidati, 25～35 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 10～30 parts of Radix Aconiti, 30～50 parts of Radix Saposhnikoviaes, 10～30 parts of Radix Aconiti Lateralis, 20～40 parts of Rhizoma Chuanxiongs, 20～50 parts of Semen Sinapis Albaes, 10～20 parts in Herba Ephedrae, 5～20 parts of Stigma Crocis, 15～35 parts of Bungarus Parvus, 20～50 parts of Cortex Phellodendris, 10～30 parts of stir-baked SQUAMA MANITISs, 10～20 parts of Radix Notoginseng, 10～20 parts of Scorpios, 20～40 parts of Cortex Dictamni, 20～40 parts of Radix Et Rhizoma Rheis.
The medicine for external use of described treatment ankylosing spondylitis, rheumatoid arthritis is preferably processed by the following raw materials that with the weight portion is unit: 30 parts of Rhizoma Polygoni Cuspidati, 30 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 20 parts of Radix Aconiti, 40 parts of Radix Saposhnikoviaes, 20 parts of Radix Aconiti Lateralis, 30 parts of Rhizoma Chuanxiongs, 30 parts of Semen Sinapis Albaes, 15 parts in Herba Ephedrae, 10 parts of Stigma Crocis, 20 parts of Bungarus Parvus, 30 parts of Cortex Phellodendris, 20 parts of stir-baked SQUAMA MANITISs, 15 parts of Radix Notoginseng, 15 parts of Scorpios, 30 parts of Cortex Dictamni, 30 parts of Radix Et Rhizoma Rheis.
The processing method of the medicine for external use of described treatment ankylosing spondylitis, rheumatoid arthritis, its concrete steps are:
A, take by weighing each crude drug of described weight portion, standby;
B, the stir-baked SQUAMA MANITIS with described weight portion, Scorpio and Bungarus Parvus are singly ground respectively to crossing 100～120 purpose fine powders;
After this 12 flavor medicine of c, the Rhizoma Polygoni Cuspidati with described weight portion, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix Aconiti, Radix Saposhnikoviae, Radix Aconiti Lateralis, Rhizoma Chuanxiong, Semen Sinapis Albae, Herba Ephedrae, Cortex Phellodendri, Radix Notoginseng, Cortex Dictamni and Radix Et Rhizoma Rhei rolls altogether, therefrom sieve is got 1/6～1/8 granularity greater than 20 purpose coarse powder, and all the other roll altogether for crossing 100～120 and get fine powder;
D, with the coarse powder of Stigma Croci in " c item " of described weight portion roll altogether for cross 100～120 fine powder;
E, get each fine powder in " b item ", place together in the mortar, successively with " c item " fine powder, " d item " fine powder facing-up successively, grind evenly after, cross 120 mesh sieves, promptly obtain the medicine for external use of described treatment ankylosing spondylitis, rheumatoid arthritis.
The traditional Chinese medical science is thought the cause of disease and the natural endowment deficiency of these " insensitive impediment " diseases such as ankylosing spondylitis, rheumatoid arthritis, and kidney qi is lost empty, the damp and hot pathogen of affection of exogenous wind-cold, and eating and drinking without temperances etc. are all multifactor relevant.When the course of disease with the passing of time, the pathogen impatency, hematogenous blockage has more the symptom of existing blood stasis.Clinical common cold-dampness numbness, damp and hot numbness resistance, kidney qi is lost empty, the obstruction of collaterals by blood stasis syndrome.The cold-dampness numbness card is with waist sacrum cold type of pain, and is heavy, aversion to wind and cold, and pale tongue with white fur, stringy and tense pulse is a main symptom, controls suitable dispelling cold and removing dampness, removing obstruction in the collateral to relieve pain.The heat that occurs together, knee joint are demonstrate,proved with lumbus sacrum pain in damp and hot numbness resistance, periphery arthralgia such as ankle, or see conjunctival congestion and swelling pain, thirsty, red tongue with yellow fur is thick or greasy, and slippery and rapid pulse is a main symptom, controls suitable clearing away heat-damp and promoting diuresis, removing obstruction in the collateral to relieve pain, kidney qi lose deficiency syndrome aches with waist, and talalgia is a main symptom, deficiency of YIN person accompanies xerostomia more partially, dysphoria with feverish sensation in the chest palms and soles, the red tongue tongue is few, deep-thready pulse; Yang deficiency person accompanies neurolysis partially, cold extremities with aversion to cold, and pale tongue with white fur, deep pulse is unable, and controlling the kidney invigorating to be main.
In the external used medicine of treatment ankylosing spondylitis of the present invention, rheumatoid arthritis:
Rhizoma Polygoni Cuspidati: bitter cold, go into liver, lung, gallbladder meridian.But the dampness removing jaundice eliminating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, blood circulation promoting competent silt.Be used for jaundice due to damp-heat, pyretic stranguria, constipation with heat retention, excessive thirst, cough due to lung-heat, amenorrhea, dysmenorrhea, external sore swollen toxin, venom, traumatic injury, disease piece.
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae): little hardship, temperature is gone into lung, kidney,liver,spleen four warps.But relaxing muscles and tendons and activating QI and blood in the collateral, the circulation of qi promoting damp eliminating, cold expelling dispels the wind, eliminating dampness to stop diarrhea.Be used for traumatic injury, fracture pain person, the arthralgia aggravated by cold of cold and damp stagnation, affection of exogenous wind-cold, heating fear of cold, head-body-pain.Be used for distension and fullness in the abdomen, malaise, anorexia, poor appetite, dysentery person.
Radix Aconiti: hot in nature, acrid in the mouth, hardship; Very toxic.But expelling wind and removing dampness, antalgic.Being used for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type has a pain.
Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature is returned bladder, liver, spleen channel.But expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.Be used for diseases caused by exogenous pathogenic factor exterior syndrome, rubella pruritus, rheumatic arthralgia, tetanus.
Radix Aconiti Lateralis: hot, sweet, big heat, poisonous, GUIXIN, kidney channel.But recuperating depleted YANG and rescuing the patient from collapse, it is supporing yang to mend fire, by wind-cold damp pathogen.Be used for the YANG-depletion collapse, the cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes, carbuncle of yin nature skin infection.
Rhizoma Chuanxiong: suffering, temperature is returned liver, gallbladder, pericardium channel.But blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Semen Sinapis Albae: acrid in the mouth, heat, nontoxic.But warming the lung eliminating phlegm promoting the circulation of QI, the resolving mass and removing the obstruction of the collateral pain relieving.Be used for cold-phlegm and breath with cough, distending pain in the chest and hypochondrium, the expectorant meridians that stagnate, joint numbness, pain, phlegm-damp oozing in the body, carbuncle of yin nature toxic swelling.
Herba Ephedrae: hot, little hardship, temperature.Return lung, urinary bladder channel.But the diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Be used for anemofrigid cold, uncomfortable in chest breathing with cough, edema due to wind pathogen edema, bronchial asthma.
Stigma Croci: flat; Sweet; GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling stimulates the menstrual flow, removing pathogenic heat from blood and toxic substance from the body.Be used for amenorrhea abdominal mass abdominal mass, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is vexed, and palpitation with fear is gone mad.
Bungarus Parvus: sweet in the mouth, salty, warm in nature, poisonous, return Liver Channel.Major function is wind-damp dispelling, the meridian dredging, relieving convulsion counteracting toxic substances.Clinical rheumatoid arthritis stubborn, numbness contracture, hemiplegia, facial hemiparalysis, tic spasm, tetanus, leprosy scabies, the scrofula malignant boil of being used for.
Cortex Phellodendri: hardship, cold, return kidney, urinary bladder channel.But heat clearing and damp drying, pathogenic fire purging are removed and are steamed, and skin ulcer is treated in detoxifcation.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.
Stir-baked SQUAMA MANITIS: salty in the mouth, cold nature is gone into liver, stomach two warps.Can subside a swelling suppuration, the silt collateral dredging that looses, stimulate the menstrual flow, stimulating milk secretion, invigorating blood circulation analgesia.Cure mainly that the carbuncle skin ulcer is swollen, anemofrigid-damp arthralgia, amenorrhea, galactostasis, hemostasis, disease crust gather.
Radix Notoginseng: sweet and slightly bitter taste, warm in nature, return liver, stomach warp, can blood pressure lowering, blood sugar lowering, blood fat reducing, have good hemostasia effect, significant hemopoietic function.
Scorpio: have another name called Scorpio, Scorpio, Scorpio, have the spasmolytic of relieving dizziness, high fever, infantile convulsions, epilepsy, etc., antiinflammatory counteracting toxic substances, removing obstruction in the collateral to relieve pain function, cure mainly diseases such as infantile convulsion, tic spasm, dermatosis, cardiovascular and cerebrovascular disease, inflammation, hepatitis B, tumor.
Cortex Dictamni: bitter cold, go into spleen, the stomach warp.Heat-clearing and toxic substances removing, expelling wind and removing dampness.Be used for diseases such as damp and hot sore, rubella, scabies, skin scratch, arthralgia chiefly caused by damp pathogen, jaundice.
Radix Et Rhizoma Rhei: gas delicate fragrance, bitter in the mouth and little puckery, purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Be used for the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire, upper gastrointestinal hemorrhage.
More than all medicines lump together use, have warming the meridian blood stasis dispelling, warming for eliminaring cold-damp, the stimulate the menstrual flow effect of collateral dredging, promoting blood circulation and stopping pain, blood stasis-eliminating and stagnation-dissipating, the strong ridge of the kidney invigorating, can be used for treating various types of ankylosing spondylitises, rheumatoid arthritis, and the destruction of sclerotin and necrosis had repair and the regeneration effect, can receive ideal therapeutic effect in a short time.
The medicine for external use of treatment ankylosing spondylitis of the present invention, rheumatoid arthritis, through clinical practice for many years, thousands of routine patients are followed the tracks of treatment, patient's clinical symptoms of 100% improves, patient's lab index of 95% improves, and patient's rheumatoid factor of 66% is turned out cloudy.Morning through curing, mid-term patient activity freely, blood fortune is able to unimpededly around the spinal column, the osteoarthrosis peripheral blood flow is accelerated, sclerotin obtains enough nutrition, articular cartilage activating and regenerating, bone metabolism recover normally gradually, arthroncus, pain symptom alleviate and disappear; End-stage patients through curing, periarticular sclerotic bone is partly dissolved absorption, corrosive hone lamella obtains repairing, the synovial membrane that thickens restores to the original state, and joint motion is no longer limited, and spinal curvature is improved more than 50% than treatment is preceding, what have is straight and upright substantially, complexion takes a turn for the better as ordinary person, and erythrocyte sedimentation rate keeps can working and work below the normal value.
Below further set forth the beneficial effect of medicine of the present invention by some model cases:
Case 1: solemn certain, man, 17 years old, student, people from Xinyang, first visit time: on October 20th, 2006.
The main suit: the two hips of patient, spinal column, two knee joint pain 3 years are surplus, the heat that occurs together, morning deadlock.Increase the weight of nearly January.History of present illness: the patient did not have obvious inducement and heating occurs in the time of 14 years old, about body temperature 37.5 degree, the uncomfortable pain in sacroiliac joint place, left side occurred, and whole body discomfort is ached.Morning stiff phenomenon.Once be in hospital diagnosis " rheumatic fever " at local county hospital.After giving the oral medicine treatment, sx, fever appears in nearly January, double knee joint swells and ache and take out hydrops, two hips and spinal pain stiff sense.I went to a doctor at institute afterwards.
Existing disease: the two hips of patient, spinal column, two knee joint pain, the red and swollen heating of knee joint, do not increase the weight of night, heating every afternoon, about 37.5 °, pale tongue, HUANGBAI(sic).Morning deadlock, the anemia looks.The patient once suffered from hepatitis A, and was surplus January with dexamethasone, the medicine-less allergy history.
The training health check-up: the positive levied in patient's 4 words, two sacroiliac jointes, breast, lumbar vertebra, psoas major, both shoulders articular pain (+), percussion pain (+) is because of patient's bed can not be stood, inferior lumbar function can not be looked into, and stretches 8 ° behind the cervical vertebra, anteflexion 80 °, 15 ° of left and right sides lateral bendings, 60 ° of left rotation and right rotation, lumbar vertebra is anteflexion 15 °, after stretch 0 °, 5 ° of left and right sides lateral bendings, rachiocamposis test 13.5-10=3.5cm (normal 〉=5cm).
Auxiliary examination: erythrocyte sedimentation rate 70mm/h, the HLA-B27 positive.
The X-ray film making shows: bilateral sacroiliac joint gap is fuzzy, has the worm-eaten sample to change.
Diagnosis: ankylosing spondylitis, the double hip joint inflammation, the bilateral femoral head necrosis, two gonyoceles have hydrops.After using 2 course of therapy of medicine of the present invention, body temperature is normal, and spiritual complexion takes a turn for the better, and left knee-joint pain alleviates, and can exert oneself, and double hip joint takes a turn for the better bitterly.
After 5 courses of treatment, the more preceding alleviation of flank pain, body temperature is normal, and the leukocyte blood sedimentation is all normal; appetite is good, sleep can, stand up and bend over to wait daily routines more preceding easily, two hip symptoms are motionless not bitterly; the more preceding obvious alleviation of pain when movable, two knee joint pneumonedema, not red, not hot, symptom before takes a favorable turn.
After 7 courses of treatment, left hip pain disappears substantially, and it is more than half that joint, former left side acid precipitation reappears improvement, former xerostomia, and existing the improvement, the whole body joint is no longer stiff, sleeps.
Use medicine of the present invention after 12 courses of treatment, pain degree alleviates, cervical region substantially not bitterly, hip joint function recovers normally substantially, sacroiliac joint before is clearly better, two knee joints are normal.Stretch 15 ° behind the cervical vertebra, anteflexion 80 °, 45 ° of left and right sides lateral bendings, 70 ° of left rotation and right rotation, lumbar vertebra is anteflexion 90 °, after stretch 20 °, 35 ° of left and right sides lateral bendings, rachiocamposis test 14.8-10=4.8cm (normal 〉=5cm).Body temperature is normal.Life can be taken care of oneself.Erythrocyte sedimentation rate 10mm/h.
Case 2: Chen, the man, 16 years old, the student, people from Zhumadian City, the first visit time: on December 19th, 2005.
The main suit: the acid of patient's ILR portion, expand, painful, morning, stiff phenomenon 3 years was surplus.
History of present illness: the patient ILR portion occurs the second half of 2002 and aches, and oral administration calcium tablet pain disappears, and morning, stiff phenomenon was 3 years, the position of squatting down, lumbosacral region discomfort when standing for a long time.Left knee joint pain appears in a nearly week, but double inguinal groove and hip are asymptomatic.At Wuhan Tongji University hospital diagnosis is " ankylosing spondylitis ".Locality city center hospital looks into the HLA-27 positive.I went to a doctor at institute afterwards.Body constitution still can, greasy fur on tongue, thick, few yellow.The patient does not have previously special medical history, medicine-less allergy history.
The training health check-up: the positive levied in patient's 4 words, right side sacroiliac joint place's tenderness (+), percussion pain (+), spinous process place tenderness (+), spinal column is bent tenderness (+), lumbar vertebra is anteflexion 45 °, after stretch 15 °, each 20 ° of left and right sides lateral bendings, the lumbar vertebra bend test is by 10cm-14.5cm, is worth to be 4.5cm.The double hip joint depletion of YANG sexually revises, and two lower limb are raised 85 °, and pelvis does all one can to test (+).36.5 ℃ of the temperature of having a medical check-up.
Auxiliary examination: the HLA-B27 positive.
The X-ray film making is shown: the lumbar vertebra physiological bending disappears, and the sacroiliac joint gap is fuzzy, has the worm-eaten sample to change.Waist sacrum gap turn narrow.
Diagnosis: ankylosing spondylitis
After using 8 course of therapy of medicine of the present invention, the existing conscious improvement of the existing conscious pain of pain during former standing up, not existing smoothly conscious improvement during former squatting down.The spinal column stiff time in morning shortens before the treatment.Overcast and rainy sx.
After using 12 course of therapy of medicine of the present invention, the former difficulty of squatting down is existing normal, and the former difficulty of standing up is existing normal.Painful existing basic disappearance of former right knee joint, and 4 li of walking.The waist activity freely.The Changes in weather influence is little.Existing conscious basic as ordinary person.Lumbar vertebra is anteflexion 90 °, after stretch 15 °, left and right sides lateral bending each 30 °, cervical vertebrate active degree is anteflexion 80 °, after stretch 40 °, left and right sides lateral bending is respectively 30 °, 45 °, conscious cervical vertebra is brisk.
Case 3: Song, man, 15 years old, student, people from Dongming County, Shandong.The first visit time: on November 9th, 2006.
The main suit: the right hip arthralgia of patient, low grade fever 2 years is surplus, and morning, stiff phenomenon was not obvious.
History of present illness: the patient did not have obvious inducement and the right hip arthralgia occurs in the time of 12 years old, walked lamely, and local hospital is diagnosed as " ankylosing spondylitis ", give the oral medicine treatment so far, once used the antibiotic therapy first quarter moon surplus, at that time sx, drug withdrawal postemphasis in January does not alleviate behind the reuse medicine.Originally accompany low grade fever, I went to a doctor at institute afterwards.
Existing disease: patient right side sacroiliac joint, the hip arthralgia, walk lamely, continue low grade fever, about 37.5 ℃ of body temperature, morning, deadlock was not obvious.The patient once suffered from hepatitis B, medicine-less allergy history in the time of 10 years old.
The training health check-up: patient right side sacroiliac joint pain (+), percussion pain (+), spinal column lean forward 35 °, 45 ° of left and right sides lateral bendings, after stretch 10 °, the cervical vertebra activity is not limited, rachiocamposis test 14-10=4cm (normal 〉=5cm).
Auxiliary examination: the HLA-B27 positive.
The X-ray film making is shown: bilateral sacroiliac joint gap is fuzzy, has the worm-eaten sample to change.
Diagnosis: ankylosing spondylitis.
Use medicine of the present invention after 12 courses of treatment, pain degree alleviates, and existing body temperature is normal, and morning, stiff phenomenon disappeared, movable anteflexion 90 ° of existing spinal column, after stretch 30 °, 30 ° of left and right sides lateral bendings, 15 ° of left rotation and right rotation, the spinal column activity is not bitterly, the bilateral sacroiliac joint is kowtowed and is hit not bitterly, spinal column elasticity test feminine gender, and two hip activities are normal substantially.X-ray film shows: sacroiliac joint gap, left side before narrows down, and density is step-down slightly, the also more preceding improvement of right sacroiliac joint.
Case 4: Wang, man, 16 years old, student, people from Changyuan County, Xinxiang.The first visit time: on JIUYUE 29th, 2007.
The main suit: patient's pain in the lumbar region, sacroiliac joint is painful, right groin, hip joint, thigh and the gonalgia, walk lamely 4 years surplus.
History of present illness: the patient did not have obvious inducement in 2002 and pain in the lumbar region occurs, and sacroiliac joint is painful, and right groin, hip joint, thigh and the gonalgia are walked lamely, and local hospital gives to alleviate behind the anti-inflammatory treatment by " synovitis ".Patient's above-mentioned symptom before 9 months increases the weight of, and the low grade fever is surplus February, no morning stiff phenomenon, night sweat.Look into the HLA-B27 positive in city's orthopaedics hospital in April, 2007, is diagnosed as " ankylosing spondylitis ".The hospital admission at inventor place afterwards.
Existing disease: patient's pain in the lumbar region, sacroiliac joint is painful, and right groin, hip joint, thigh, the gonalgia are walked lamely, and the burning pain sense is arranged during pain, and pain relieved by pressing is pressed, and dry pharynx has low grade fever, and vexed irritability has a delicate constitution, lusterless complexion, red tongue, white and thin fur, pulse condition is heavy carefully unable.Continue low grade fever, about 37.5 ℃ of body temperature.The patient does not have previously special medical history, medicine-less allergy history.
The training health check-up: the positive levied in " 4 " word, the bedside test is positive, thigh and bilateral sacroiliac joint tenderness, right thigh, hip, the gonalgia.
Auxiliary examination: the HLA-B27 positive, ESR:95mm/h, CRP＞10mg/L, PLT:325 * 109/L, ASO＞500u.
The X-ray film making is shown: bilateral sacroiliac joint gap is fuzzy, has the worm-eaten sample to change.
Diagnosis: ankylosing spondylitis.
Use medicine of the present invention after one month, pain degree alleviates, and body temperature is normal, positive interior-heat sx.Treat after three months the patient and tell and take a favorable turn, the former lower limb difficulty difficulty of going to bed of lifting is unable, now can go to bed voluntarily, can abandon to turn walking but can not go on a journey, and far walks then lumbago, and is tired unable.Recover after 5 months, the state of an illness take a favorable turn again, the knee joint hypodynia, and femur is not afraid of cold and hotly not bitterly, and it is heavy that the sacroiliac position is a bit sent out.Not tired, cold perspiration sometimes, diet is normal, weight increase; It is strong to lift lower limb, and the waist mobility increases.Erythrocyte sedimentation rate 30mm/h; ASO＜500u, CRP＜10mg/L; PLT:252 * 10
9/ L; This situation shows that acute stage limits mistake. enter stable phase, burst sacrum joint after a year, all not bitterly, the patient is non fatigue feeling for knee joint; Diet is good, sleep.Have a blood test heavy, c reactive protein, ASO is all normal.The HLA-B27 titre is lower than 1, and is normal substantially.
The specific embodiment:
Embodiment 1: a kind of medicine for external use for the treatment of ankylosing spondylitis, rheumatoid arthritis is processed by the following raw materials that with the weight portion is unit: 25 parts of Rhizoma Polygoni Cuspidati, 25 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 10 parts of Radix Aconiti, 30 parts of Radix Saposhnikoviaes, 10 parts of Radix Aconiti Lateralis, 20 parts of Rhizoma Chuanxiongs, 20 parts of Semen Sinapis Albaes, 10 parts in Herba Ephedrae, 5 parts of Stigma Crocis, 15 parts of Bungarus Parvus, 20 parts of Cortex Phellodendris, 10 parts of stir-baked SQUAMA MANITISs, 10 parts of Radix Notoginseng, 10 parts of Scorpios, 20 parts of Cortex Dictamni, 20 parts of Radix Et Rhizoma Rheis.
Above the processing method of medicine for external use of described treatment ankylosing spondylitis, rheumatoid arthritis, its concrete steps are:
A, take by weighing each crude drug of described weight portion, standby;
B, the stir-baked SQUAMA MANITIS with described weight portion, Scorpio and Bungarus Parvus are singly ground respectively to crossing 100～120 purpose fine powders;
After this 12 flavor medicine of c, the Rhizoma Polygoni Cuspidati with described weight portion, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix Aconiti, Radix Saposhnikoviae, Radix Aconiti Lateralis, Rhizoma Chuanxiong, Semen Sinapis Albae, Herba Ephedrae, Cortex Phellodendri, Radix Notoginseng, Cortex Dictamni and Radix Et Rhizoma Rhei rolls altogether, therefrom sieve is got 1/6～1/8 granularity greater than 20 purpose coarse powder, and all the other roll altogether for crossing 100～120 and get fine powder;
D, with the coarse powder of Stigma Croci in " c item " of described weight portion roll altogether for cross 100～120 fine powder;
E, get each fine powder in " b item ", place together in the mortar, successively with " c item " fine powder, " d item " fine powder facing-up successively, grind evenly after, cross 120 mesh sieves, promptly obtain the medicine for external use of described treatment ankylosing spondylitis, rheumatoid arthritis.
Embodiment 2: the processing method of present embodiment and embodiment 1 is basic identical, something in common does not repeat, difference is: a kind of medicine for external use for the treatment of ankylosing spondylitis, rheumatoid arthritis is processed by the following raw materials that with the weight portion is unit: 35 parts of Rhizoma Polygoni Cuspidati, 35 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 30 parts of Radix Aconiti, 50 parts of Radix Saposhnikoviaes, 30 parts of Radix Aconiti Lateralis, 40 parts of Rhizoma Chuanxiongs, 50 parts of Semen Sinapis Albaes, 20 parts in Herba Ephedrae, 20 parts of Stigma Crocis, 35 parts of Bungarus Parvus, 50 parts of Cortex Phellodendris, 30 parts of stir-baked SQUAMA MANITISs, 20 parts of Radix Notoginseng, 20 parts of Scorpios, 40 parts of Cortex Dictamni, 40 parts of Radix Et Rhizoma Rheis.
Embodiment 3: the processing method of present embodiment and embodiment 1 is basic identical, something in common does not repeat, difference is: a kind of medicine for external use for the treatment of ankylosing spondylitis, rheumatoid arthritis is processed by the following raw materials that with the weight portion is unit: 30 parts of Rhizoma Polygoni Cuspidati, 30 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 20 parts of Radix Aconiti, 40 parts of Radix Saposhnikoviaes, 20 parts of Radix Aconiti Lateralis, 30 parts of Rhizoma Chuanxiongs, 30 parts of Semen Sinapis Albaes, 15 parts in Herba Ephedrae, 10 parts of Stigma Crocis, 20 parts of Bungarus Parvus, 30 parts of Cortex Phellodendris, 20 parts of stir-baked SQUAMA MANITISs, 15 parts of Radix Notoginseng, 15 parts of Scorpios, 30 parts of Cortex Dictamni, 30 parts of Radix Et Rhizoma Rheis.
Embodiment 4: the processing method of present embodiment and embodiment 1 is basic identical, something in common does not repeat, difference is: a kind of medicine for external use for the treatment of ankylosing spondylitis, rheumatoid arthritis is processed by the following raw materials that with the weight portion is unit: 27 parts of Rhizoma Polygoni Cuspidati, 32 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 20 parts of Radix Aconiti, 15 parts of Radix Saposhnikoviaes, 25 parts of Radix Aconiti Lateralis, 25 parts of Rhizoma Chuanxiongs, 40 parts of Semen Sinapis Albaes, 12 parts in Herba Ephedrae, 10 parts of Stigma Crocis, 30 parts of Bungarus Parvus, 45 parts of Cortex Phellodendris, 15 parts of stir-baked SQUAMA MANITISs, 15 parts of Radix Notoginseng, 13 parts of Scorpios, 30 parts of Cortex Dictamni, 25 parts of Radix Et Rhizoma Rheis.
Embodiment 5: the processing method of present embodiment and embodiment 1 is basic identical, something in common does not repeat, difference is: a kind of medicine for external use for the treatment of ankylosing spondylitis, rheumatoid arthritis is processed by the following raw materials that with the weight portion is unit: 32 parts of Rhizoma Polygoni Cuspidati, 27 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 15 parts of Radix Aconiti, 45 parts of Radix Saposhnikoviaes, 15 parts of Radix Aconiti Lateralis, 35 parts of Rhizoma Chuanxiongs, 30 parts of Semen Sinapis Albaes, 17 parts in Herba Ephedrae, 15 parts of Stigma Crocis, 20 parts of Bungarus Parvus, 25 parts of Cortex Phellodendris, 25 parts of stir-baked SQUAMA MANITISs, 18 parts of Radix Notoginseng, 17 parts of Scorpios, 35 parts of Cortex Dictamni, 35 parts of Radix Et Rhizoma Rheis.
Embodiment 6: the processing method of present embodiment and embodiment 1 is basic identical, something in common does not repeat, difference is: a kind of medicine for external use for the treatment of ankylosing spondylitis, rheumatoid arthritis is processed by the following raw materials that with the weight portion is unit: 30 parts of Rhizoma Polygoni Cuspidati, 25 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 30 parts of Radix Aconiti, 30 parts of Radix Saposhnikoviaes, 30 parts of Radix Aconiti Lateralis, 20 parts of Rhizoma Chuanxiongs, 50 parts of Semen Sinapis Albaes, 10 parts in Herba Ephedrae, 20 parts of Stigma Crocis, 35 parts of Bungarus Parvus, 20 parts of Cortex Phellodendris, 10 parts of stir-baked SQUAMA MANITISs, 20 parts of Radix Notoginseng, 20 parts of Scorpios, 30 parts of Cortex Dictamni, 25 parts of Radix Et Rhizoma Rheis.
Claims (3)
1. medicine for external use for the treatment of ankylosing spondylitis, rheumatoid arthritis, it is characterized in that: process: 25～35 parts of Rhizoma Polygoni Cuspidati by the following raw materials that with the weight portion is unit, 25～35 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 10～30 parts of Radix Aconiti, 30～50 parts of Radix Saposhnikoviaes, 10～30 parts of Radix Aconiti Lateralis, 20～40 parts of Rhizoma Chuanxiongs, 20～50 parts of Semen Sinapis Albaes, 10～20 parts in Herba Ephedrae, 5～20 parts of Stigma Crocis, 15～35 parts of Bungarus Parvus, 20～50 parts of Cortex Phellodendris, 10～30 parts of stir-baked SQUAMA MANITISs, 10～20 parts of Radix Notoginseng, 10～20 parts of Scorpios, 20～40 parts of Cortex Dictamni, 20～40 parts of Radix Et Rhizoma Rheis.
2. the medicine for external use of treatment ankylosing spondylitis according to claim 1, rheumatoid arthritis is characterized in that: processed by the following raw materials that with the weight portion is unit: 30 parts of Rhizoma Polygoni Cuspidati, 30 parts of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae)s, 20 parts of Radix Aconiti, 40 parts of Radix Saposhnikoviaes, 20 parts of Radix Aconiti Lateralis, 30 parts of Rhizoma Chuanxiongs, 30 parts of Semen Sinapis Albaes, 15 parts in Herba Ephedrae, 10 parts of Stigma Crocis, 20 parts of Bungarus Parvus, 30 parts of Cortex Phellodendris, 20 parts of stir-baked SQUAMA MANITISs, 15 parts of Radix Notoginseng, 15 parts of Scorpios, 30 parts of Cortex Dictamni, 30 parts of Radix Et Rhizoma Rheis.
3. the processing method of the medicine for external use of the described treatment ankylosing spondylitis of claim 2, rheumatoid arthritis, its concrete steps are:
A, take by weighing each crude drug of described weight portion, standby;
B, the stir-baked SQUAMA MANITIS with described weight portion, Scorpio and Bungarus Parvus are singly ground respectively to crossing 100～120 purpose fine powders;
After this 12 flavor medicine of c, the Rhizoma Polygoni Cuspidati with described weight portion, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix Aconiti, Radix Saposhnikoviae, Radix Aconiti Lateralis, Rhizoma Chuanxiong, Semen Sinapis Albae, Herba Ephedrae, Cortex Phellodendri, Radix Notoginseng, Cortex Dictamni and Radix Et Rhizoma Rhei rolls altogether, therefrom sieve is got 1/6～1/8 granularity greater than 20 purpose coarse powder, and all the other roll altogether for crossing 100～120 and get fine powder;
D, with the coarse powder of Stigma Croci in " c item " of described weight portion roll altogether for cross 100～120 fine powder;
E, get each fine powder in " b item ", place together in the mortar, successively with " c item " fine powder, " d item " fine powder facing-up successively, grind evenly after, cross 120 mesh sieves, promptly obtain the medicine for external use of described treatment ankylosing spondylitis, rheumatoid arthritis.
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