CN105287747A - Traditional Chinese medicine composition for treating spinal cord injury as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating spinal cord injury as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating spinal cord injury as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 16-22 parts of peperomia tetraphylla, 7-11 parts of white baneberry and 4-7 parts of ormosia. The preparation method comprises the following steps: crushing the ormosia, adding an ethanol solution for carrying out reflux extraction three times, filtering to obtain filtrate, and concentrating to obtain ormosia extract; mixing the peperomia tetraphylla, the white baneberry and the ormosia dreg, adding distilled water for soaking, boiling and extracting three times, mixing the extracting solutions, filtering, and concentrating to obtain thick paste; and mixing the ormosia extract and the thick paste to obtain granules. The traditional Chinese medicine composition disclosed by the invention has the effects of dispelling wind and eliminating dampness, promoting blood circulation and dissipating blood stasis, activating meridians to stop pain as well as promoting reunion of fractured bones, has a unique curative effect on treating spinal cord injury, can achieve the aim of treating both symptoms and root causes, and is low in price, so that the traditional Chinese medicine composition is worthy of being widely popularized and applied clinically.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically a kind of Chinese medicine composition for the treatment of spinal cord injury and preparation method thereof and application.
Background technology
Spinal cord injury is the severe complication of spinal fracture, because the displacement of vertebral body or bone cips protrude from intraspinal tube, makes spinal cord or cauda equina nerve produce damage in various degree.Can occur together in cervical vertebra, thoracic vertebra, breast waist, lumbar vertebra, sacral fracture, cause limb movement disturbance, sensory disturbance, defecation obstacle.Be more common in person between twenty and fifty, male is in the majority, and modal damage location is low neck marrow in being, is secondly breast waist intersection.Spinal concussion, the lighter's a few hours, severe one can recover normal in 2 ~ 3 weeks completely.Compression of spinal cord, if in time remove compressing factor, spinal function can all or major part recovery, otherwise ischemia of spinal cord is downright bad, so that can not recover.
Along with the development of countries in the world economic level, spinal cord injury incidence rate presents the trend increased year by year.Spinal cord injury is the most serious complication of spinal injury, often causes damaging sections with the serious dysfunction of lower limb body.Spinal cord injury not only can bring the grievous injury of health and psychology to sufferers themselves, also can cause huge financial burden to entire society.Due to the Socie-economic loss that spinal cord injury causes, become a large problem of current medical circle for the prevention of spinal cord injury, treatment and rehabilitation.
Semen Phaseoli, another name ormosia hosiei, Jiangyin Ormosia hosiei are the seed of leguminous plant Ormosia hosiei, and containing N-Methylcytisine, N-methyl tetrahydrochysene eulexine, Semen Phaseoli splits alkali, and 18-shows Semen Phaseoli and splits alkali and piptanthine, also containing protein.Bitter in the mouth, property is put down, and mild toxicity, returns liver, spleen channel, has effect of vital energy regualting and blood circulation-promoting, heat-clearing and toxic substances removing.Main heart peratodynia; Hernia pain; Amenorrhea due to stagnation of blood; Innominate toxic swelling; Furuncle.
Summary of the invention
The object of the present invention is to provide a kind of low cost, evident in efficacy, Chinese medicine composition for the treatment of spinal cord injury of having no side effect and preparation method thereof and application.
For achieving the above object, the invention provides following technical scheme:
Treat a Chinese medicine composition for spinal cord injury, be made up of the raw material of following mass parts: Herba Seu Radix Peperomiae Tetraphyllae 16 ~ 22 parts, Niu Wang false aloe 7 ~ 11 parts, 4 ~ 7 parts, Semen Phaseoli.
As the further scheme of the present invention: be made up of the raw material of following mass parts: Herba Seu Radix Peperomiae Tetraphyllae 18 ~ 21 parts, Niu Wang false aloe 8 ~ 10 parts, 4 ~ 6 parts, Semen Phaseoli.
As the further scheme of the present invention: be made up of the raw material of following mass parts: Herba Seu Radix Peperomiae Tetraphyllae 20 parts, Niu Wang false aloe 9 parts, 5 parts, Semen Phaseoli.
The preparation method of the Chinese medicine composition of described treatment spinal cord injury, comprises the following steps:
(1) get red bean powder and be broken into coarse powder, the alcoholic solution that volumetric concentration is 65 ~ 85% is added according to 5 ~ 8 times amount of meal quality, reflux, extract, three times, return time is 1 ~ 2h, filtration obtains filtrate, and after gained filtrate being merged, at concentrating under reduced pressure is 60 DEG C, relative density is the Semen Phaseoli extractum of 1.15 ~ 1.18, Semen Phaseoli slag after extraction retains, for subsequent use;
(2), after getting the Semen Phaseoli slag mix homogeneously after Herba Seu Radix Peperomiae Tetraphyllae, Niu Wang false aloe and step (1) extraction, add the distilled water of 8 ~ 10 times amount, soak after 4 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add the distilled water of 6 ~ 8 times amount, boil 2 ~ 3 hours, extract; Finally, add the distilled water of 4 ~ 6 times amount, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter to get filtrate, gained filtrate being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(3) thick paste obtained with step (2) for Semen Phaseoli extractum obtained for step (1) is mixed, make granule, be the Chinese medicine composition of described treatment spinal cord injury.
The using method of the Chinese medicine composition of described treatment spinal cord injury is: oral, every day 2 times, early, each 1 time of evening, each serving with the dosage being equivalent to 20g crude drug amount, after meal half an hour warm boiled water; Within 10 days, be 1 course for the treatment of, 3 ~ 4 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
The application of described Chinese medicine composition in the medicine of preparation treatment spinal cord injury.
Compared with prior art, the invention has the beneficial effects as follows:
Selected by Chinese medicine composition of the present invention, medical material compatibility is suitable, meets Chinese medicine and pharmacy and modern medicine theory, and evident in efficacy, Patients of Spinal is broken away from misery, non-relapse after healing, safe without toxic side effect, and special effect is practical.
Chinese medicine composition of the present invention with the Herba Seu Radix Peperomiae Tetraphyllae of expelling wind and removing dampness, promoting blood circulation and stopping pain for principal agent, with the Semen Phaseoli of the Niu Wang false aloe of promoting blood circulation to remove obstruction in the collateral, removing toxic substances and promoting subsidence of swelling and vital energy regualting and blood circulation-promoting, heat-clearing and toxic substances removing for accessory drugs, there is effect of expelling wind and removing dampness, promoting blood circulation to remove blood stasis, removing obstruction in the collateral to relieve pain, reunion of fractured tendons and bones, to treatment spinal cord injury, there is unique curative effect, can the object for the treatment of both the principal and secondary aspects of a disease, cheap, wide popularization and application on clinic.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of spinal cord injury, is made up of the raw material of following mass parts: Herba Seu Radix Peperomiae Tetraphyllae 22 parts, Niu Wang false aloe 7 parts, 4 parts, Semen Phaseoli.
The preparation method of the Chinese medicine composition of described treatment spinal cord injury, comprises the following steps:
(1) get red bean powder and be broken into coarse powder, the alcoholic solution that volumetric concentration is 85% is added according to 5 times amount of meal quality, reflux, extract, three times, return time is 1h, filtration obtains filtrate, and after gained filtrate being merged, at concentrating under reduced pressure is 60 DEG C, relative density is the Semen Phaseoli extractum of 1.15, Semen Phaseoli slag after extraction retains, for subsequent use;
(2), after getting the Semen Phaseoli slag mix homogeneously after Herba Seu Radix Peperomiae Tetraphyllae, Niu Wang false aloe and step (1) extraction, add the distilled water of 8 times amount, soak after 6 hours, boil 3 hours, extract; Again add the distilled water of 6 times amount, boil 2 hours, extract; Finally, add the distilled water of 4 times amount, heated and boiled 1 hour, extract; Merge three extracting solution, filter to get filtrate, gained filtrate being condensed into relative density at 60 DEG C is the thick paste of 1.13, for subsequent use;
(3) thick paste obtained with step (2) for Semen Phaseoli extractum obtained for step (1) is mixed, make granule, be the Chinese medicine composition of described treatment spinal cord injury.
Embodiment 2
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of spinal cord injury, is made up of the raw material of following mass parts: Herba Seu Radix Peperomiae Tetraphyllae 16 parts, Niu Wang false aloe 11 parts, 7 parts, Semen Phaseoli.
The preparation method of the Chinese medicine composition of described treatment spinal cord injury, comprises the following steps:
(1) get red bean powder and be broken into coarse powder, the alcoholic solution that volumetric concentration is 85% is added according to 5 times amount of meal quality, reflux, extract, three times, return time is 1h, filtration obtains filtrate, and after gained filtrate being merged, at concentrating under reduced pressure is 60 DEG C, relative density is the Semen Phaseoli extractum of 1.15, Semen Phaseoli slag after extraction retains, for subsequent use;
(2), after getting the Semen Phaseoli slag mix homogeneously after Herba Seu Radix Peperomiae Tetraphyllae, Niu Wang false aloe and step (1) extraction, add the distilled water of 8 times amount, soak after 6 hours, boil 3 hours, extract; Again add the distilled water of 6 times amount, boil 2 hours, extract; Finally, add the distilled water of 4 times amount, heated and boiled 1 hour, extract; Merge three extracting solution, filter to get filtrate, gained filtrate being condensed into relative density at 60 DEG C is the thick paste of 1.13, for subsequent use;
(3) thick paste obtained with step (2) for Semen Phaseoli extractum obtained for step (1) is mixed, make granule, be the Chinese medicine composition of described treatment spinal cord injury.
Embodiment 3
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of spinal cord injury, is made up of the raw material of following mass parts: Herba Seu Radix Peperomiae Tetraphyllae 21 parts, Niu Wang false aloe 8 parts, 4 parts, Semen Phaseoli.
The preparation method of the Chinese medicine composition of described treatment spinal cord injury, comprises the following steps:
(1) get red bean powder and be broken into coarse powder, the alcoholic solution that volumetric concentration is 65% is added according to 8 times amount of meal quality, reflux, extract, three times, return time is 2h, filtration obtains filtrate, and after gained filtrate being merged, at concentrating under reduced pressure is 60 DEG C, relative density is the Semen Phaseoli extractum of 1.18, Semen Phaseoli slag after extraction retains, for subsequent use;
(2), after getting the Semen Phaseoli slag mix homogeneously after Herba Seu Radix Peperomiae Tetraphyllae, Niu Wang false aloe and step (1) extraction, add the distilled water of 10 times amount, soak after 4 hours, boil 4 hours, extract; Again add the distilled water of 8 times amount, boil 3 hours, extract; Finally, add the distilled water of 6 times amount, heated and boiled 2 hours, extract; Merge three extracting solution, filter to get filtrate, gained filtrate being condensed into relative density at 60 DEG C is the thick paste of 1.10, for subsequent use;
(3) thick paste obtained with step (2) for Semen Phaseoli extractum obtained for step (1) is mixed, make granule, be the Chinese medicine composition of described treatment spinal cord injury.
Embodiment 4
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of spinal cord injury, is made up of the raw material of following mass parts: Herba Seu Radix Peperomiae Tetraphyllae 18 parts, Niu Wang false aloe 10 parts, 6 parts, Semen Phaseoli.
The preparation method of the Chinese medicine composition of described treatment spinal cord injury, comprises the following steps:
(1) get red bean powder and be broken into coarse powder, the alcoholic solution that volumetric concentration is 65% is added according to 8 times amount of meal quality, reflux, extract, three times, return time is 2h, filtration obtains filtrate, and after gained filtrate being merged, at concentrating under reduced pressure is 60 DEG C, relative density is the Semen Phaseoli extractum of 1.18, Semen Phaseoli slag after extraction retains, for subsequent use;
(2), after getting the Semen Phaseoli slag mix homogeneously after Herba Seu Radix Peperomiae Tetraphyllae, Niu Wang false aloe and step (1) extraction, add the distilled water of 10 times amount, soak after 4 hours, boil 4 hours, extract; Again add the distilled water of 8 times amount, boil 3 hours, extract; Finally, add the distilled water of 6 times amount, heated and boiled 2 hours, extract; Merge three extracting solution, filter to get filtrate, gained filtrate being condensed into relative density at 60 DEG C is the thick paste of 1.10, for subsequent use;
(3) thick paste obtained with step (2) for Semen Phaseoli extractum obtained for step (1) is mixed, make granule, be the Chinese medicine composition of described treatment spinal cord injury.
Embodiment 5
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of spinal cord injury, is made up of the raw material of following mass parts: Herba Seu Radix Peperomiae Tetraphyllae 20 parts, Niu Wang false aloe 9 parts, 5 parts, Semen Phaseoli.
The preparation method of the Chinese medicine composition of described treatment spinal cord injury, comprises the following steps:
(1) get red bean powder and be broken into coarse powder, the alcoholic solution that volumetric concentration is 75% is added according to 6 times amount of meal quality, reflux, extract, three times, return time is 1.5h, filtration obtains filtrate, and after gained filtrate being merged, at concentrating under reduced pressure is 60 DEG C, relative density is the Semen Phaseoli extractum of 1.16, Semen Phaseoli slag after extraction retains, for subsequent use;
(2), after getting the Semen Phaseoli slag mix homogeneously after Herba Seu Radix Peperomiae Tetraphyllae, Niu Wang false aloe and step (1) extraction, add the distilled water of 9 times amount, soak after 5 hours, boil 4 hours, extract; Again add the distilled water of 7 times amount, boil 3 hours, extract; Finally, add the distilled water of 5 times amount, heated and boiled 2 hours, extract; Merge three extracting solution, filter to get filtrate, gained filtrate being condensed into relative density at 60 DEG C is the thick paste of 1.13, for subsequent use;
(3) thick paste obtained with step (2) for Semen Phaseoli extractum obtained for step (1) is mixed, make granule, be the Chinese medicine composition of described treatment spinal cord injury.
Chinese medicine composition of the present invention with the Herba Seu Radix Peperomiae Tetraphyllae of expelling wind and removing dampness, promoting blood circulation and stopping pain for principal agent, with the Semen Phaseoli of the Niu Wang false aloe of promoting blood circulation to remove obstruction in the collateral, removing toxic substances and promoting subsidence of swelling and vital energy regualting and blood circulation-promoting, heat-clearing and toxic substances removing for accessory drugs, there is effect of expelling wind and removing dampness, promoting blood circulation to remove blood stasis, removing obstruction in the collateral to relieve pain, reunion of fractured tendons and bones, to treatment spinal cord injury, there is unique curative effect, can the object for the treatment of both the principal and secondary aspects of a disease, cheap, wide popularization and application on clinic.
Animal acute toxicity test
Now animal acute toxicity test is carried out to Chinese medicine composition of the present invention, get Mouse and rat half and half, be divided into five groups, oral Chinese medicine composition/the kg (more than 20 times of this dosage behaviour taking dose) being equivalent to embodiment 1 ~ 5 preparation of 20g crude drug amount respectively, once a day, 7 days are continued.To observation post administration 2 weeks, do not have Mouse and rat dead, show that the toxicity of Chinese medicine composition of the present invention is very micro-.Therefore, clinical trial is carried out to the patient being diagnosed as spinal cord injury.
It is below the clinical research data of traditional Chinese medicine composition for treating spinal cord injury of the present invention
1, case selection
Patients of Spinal 400 example made a definite diagnosis is selected to carry out clinical observation, wherein male 213 example, women 187 example, 28 ~ 60 years old age, 45.6 years old mean age, the course of disease 6 months ~ 3 years, average course of disease 1.8 years.This 400 routine patient is divided at random treatment 1 ~ 5 group, contrast 1 ~ 3 group totally eight groups, often organizes 50 examples, the course of disease, the degrees of symptoms of each group patient are basically identical, without significant difference, have comparability.
2, therapeutic modality
Treat 1 ~ 5 group and take the obtained granule of the embodiment of the present invention 1 ~ 5 respectively, oral, every day 2 times, early, each 1 time of evening, each serving with the dosage being equivalent to 20g crude drug amount, after meal half an hour warm boiled water; Within 10 days, be 1 course for the treatment of, 3 ~ 4 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Contrast 1 group and take tizanidine hydrochloride sheet, patient uses the dose adjustment period that should have 2 ~ 4 weeks for the first time.Start each 2 ~ 4mg of consumption, 6 ~ 8 hours 1 time, have stronger first pass effect because this product is oral, during use, should individuation of dosage be noted.
Contrast 2 groups of granules taken only containing Herba Seu Radix Peperomiae Tetraphyllae and Niu Wang false aloe, all the other are identical with embodiment 5.Oral, every day 2 times, early, each 1 time of evening, each serving with the dosage being equivalent to 20g crude drug amount, after meal half an hour warm boiled water; Within 10 days, be 1 course for the treatment of, 3 ~ 4 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Contrast 3 groups of granules taken only containing Semen Phaseoli, all the other are identical with embodiment 5.Oral, every day 2 times, early, each 1 time of evening, each serving with the dosage being equivalent to 20g crude drug amount, after meal half an hour warm boiled water; Within 10 days, be 1 course for the treatment of, 3 ~ 4 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3, curative effect determinate standard
(1) cure: cardinal symptom all disappears, and physical recovery is as usual;
(2) effective: cardinal symptom is obviously alleviated, health is clearly better;
(3) effective: cardinal symptom is alleviated to some extent, healthyly to turn to some extent;
(4) invalid: by treating rear cardinal symptom without alleviating or increasing the weight of.
4, therapeutic outcome
The comparitive study that table 1 is respectively organized
| Project | Case load | Cure number | Effective number | Significant figure | Invalid number | Cure rate | Total effective rate |
| Treat 1 group | 50 | 26 | 13 | 9 | 2 | 52％ | 96％ |
| Treat 2 groups | 50 | 26 | 14 | 8 | 2 | 52％ | 96％ |
| Treat 3 groups | 50 | 27 | 15 | 7 | 1 | 54％ | 98％ |
| Treat 4 groups | 50 | 27 | 14 | 8 | 1 | 54％ | 98％ |
| Treat 5 groups | 50 | 28 | 15 | 6 | 1 | 56％ | 98％ |
| Contrast 1 group | 50 | 14 | 10 | 7 | 19 | 28％ | 62％ |
| Contrast 2 groups | 50 | 2 | 4 | 3 | 41 | 4％ | 18％ |
| Contrast 3 groups | 50 | 0 | 1 | 2 | 47 | 0％ | 6％ |
Through the treatment time of 3 ~ 4 courses for the treatment of, the therapeutic effect of each group is as shown in table 1: select the cure rate of the treatment group of Chinese medicine composition of the present invention to be 52 ~ 56%, total effective rate is 96 ~ 98%; The cure rate contrasting 1 group is 28%, and total effective rate is 62%; Contrast the cure rate of 2 ~ 3 groups and total effective rate all well below treatment 5 groups, contrast the curative effect that 2 groups and the contrast cure rate of 3 groups and total effective rate sum are still significantly less than treatment 5 groups, illustrate that Chinese medicine composition of the present invention just has high cure rate and effective percentage under the mutual compatibility effect of each raw material, Chinese medicine composition of the present invention is applicable to the treatment of spinal cord injury.
5, model case
Case 1: shut out certain, female, 52 years old, weight weighed wounded and causes spinal cord injury, can walk time injured, but after operative treatment, lower limb sensorimotor is lost, after taking the embodiment of the present invention 5 obtained 1 course for the treatment of of granule, lower limb sensorimotor recovers to some extent, after taking 3 courses for the treatment of, lower limb recover as usual, follow up a case by regular visits to without recurrence after 2 years.
Case 2: Wu, man, 42 years old, patient's waist was injured by a crashing object, had cold and hot pain perception, but felt poor below ankle, and plane of feeling to go down is positioned at T12 level.And two lower limb have intolerable pain, rely on medicine also cannot carry out pain relieving, can not stand and walk.Defecation is felt, and substantially can control.Be diagnosed as incomplete spinal cord injury (T12 segments of spinal cord), after taking the embodiment of the present invention 5 obtained 1 course for the treatment of of granule, symptom takes a turn for the better to some extent, and after continuing to take 2 courses for the treatment of, symptom all disappears, and follows up a case by regular visits to without recurrence after 1 year.
Case 3: Wang, female, 28 years old, the two lower limb sensorimotor function obstacle of patient more than 2 years, can not independently stand and walk, walking aid be ridden instead of walk, two lower limb muscles, and superficial sensibility weakens, pain temperature atactilia, and two muscle tension of lower extremities declines, and knee jerk weakens.All do not have effect after the hospitalize of many, locality, after taking the embodiment of the present invention 5 obtained 1 course for the treatment of of granule, two lower limb are felt a little, motor function comparatively before take a turn for the better, spirit, sleep and diet are all relatively good, and two lower limb superficial sensibility weakens comparatively and takes a turn for the better.Symptom is clearly better, and muscular strength also recovers a lot, and after continuing to take 2 courses for the treatment of, two lower limb recover sensation, and motor function recovery is as usual, transference cure, and Myodynamia recovery is as usual.
Case 4: ancestor, man, 48 years old, patient slips carelessly, causes serious spinal cord injury, cannot move normally, have a meal, sleep, walking all has become luxury, the life of whole people all cannot be taken care of oneself, and brings endless misery to oneself and household, after taking the embodiment of the present invention 5 obtained 2 courses for the treatment of of granule, upper limb has recovered function of nervous system, and two lower limb obviously reactivate function, after continuing to take 2 courses for the treatment of, upper limb nerve functional rehabilitation is as usual, and two lower limb reactivate function.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (5)
1. treat a Chinese medicine composition for spinal cord injury, it is characterized in that, be made up of the raw material of following mass parts: Herba Seu Radix Peperomiae Tetraphyllae 16 ~ 22 parts, Niu Wang false aloe 7 ~ 11 parts, 4 ~ 7 parts, Semen Phaseoli.
2. the Chinese medicine composition for the treatment of spinal cord injury according to claim 1, is characterized in that, is made up of the raw material of following mass parts: Herba Seu Radix Peperomiae Tetraphyllae 18 ~ 21 parts, Niu Wang false aloe 8 ~ 10 parts, 4 ~ 6 parts, Semen Phaseoli.
3. the Chinese medicine composition for the treatment of spinal cord injury according to claim 1, is characterized in that, is made up of the raw material of following mass parts: Herba Seu Radix Peperomiae Tetraphyllae 20 parts, Niu Wang false aloe 9 parts, 5 parts, Semen Phaseoli.
4., according to the preparation method of the Chinese medicine composition of the arbitrary described treatment spinal cord injury of claims 1 to 3, it is characterized in that, comprise the following steps:
(1) get red bean powder and be broken into coarse powder, the alcoholic solution that volumetric concentration is 65 ~ 85% is added according to 5 ~ 8 times amount of meal quality, reflux, extract, three times, return time is 1 ~ 2h, filtration obtains filtrate, and after gained filtrate being merged, at concentrating under reduced pressure is 60 DEG C, relative density is the Semen Phaseoli extractum of 1.15 ~ 1.18, Semen Phaseoli slag after extraction retains, for subsequent use;
(2), after getting the Semen Phaseoli slag mix homogeneously after Herba Seu Radix Peperomiae Tetraphyllae, Niu Wang false aloe and step (1) extraction, add the distilled water of 8 ~ 10 times amount, soak after 4 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add the distilled water of 6 ~ 8 times amount, boil 2 ~ 3 hours, extract; Finally, add the distilled water of 4 ~ 6 times amount, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter to get filtrate, gained filtrate being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(3) thick paste obtained with step (2) for Semen Phaseoli extractum obtained for step (1) is mixed, make granule, be the Chinese medicine composition of described treatment spinal cord injury.
5. the application of the Chinese medicine composition as described in as arbitrary in claims 1 to 3 in the medicine of preparation treatment spinal cord injury.
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| CN109718268B (en) * | 2017-10-31 | 2021-08-03 | 福建农林大学 | Preparation method of red bean seed extract and application of red bean seed extract in anti-inflammatory drugs |
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Application publication date: 20160203 |