CN104547232A - Traditional Chinese medicine for treating ankylosing spondylitis - Google Patents

Abstract

The invention relates to the technical field of traditional Chinese medicines and particularly relates to a traditional Chinese medicine for treating ankylosing spondylitis. The traditional Chinese medicine for treating ankylosing spondylitis is prepared from the following medicinal materials in parts by weight: 30-35 parts of herba epimedii, 15-20 parts of cortex eucommiae, 15-20 parts of herba taxilli, 15-20 parts of rhizoma cibotii, 12-15 parts of radix achyranthis bidentatae, 15-20 parts of radix rehmanniae praeparata, 12-15 parts of Chinese angelica, 12-15 parts of radix paeoniae alba, 10-12 parts of cassia twig, 10-12 parts of rhizoma chuanxiong, 15-20 parts of radix salviae miltiorrhizae, 20-25 parts of radix astragali, 10-12 parts of kadsura pepper stem, 10-12 parts of earthworm, 10-12 parts of zaocys dhumnade, 6-9 parts of frankincense, 6-9 parts of myrrh and 6-9 parts of liquoric root. The effective rate of the decoction prepared from the traditional Chinese medicine provided by the invention on treating ankylosing spondylitis is as high as 94.7%; the traditional Chinese medicine is used for treating various kinds of arthralgia caused by deficiency of the liver and kidneys, deficiency of qi and blood and nourishment loss of governor vessel while the curative effect is exact and remarkable and no toxic or side effect is caused; and the traditional Chinese medicine has the functions of warming governor vessel and tonifying the kidneys, activating blood and dredging collaterals, relieving pain and dispelling cold and dampness.

Description

A kind of Chinese medicine for the treatment of ankylosing spondylitis

Technical field

The present invention relates to technical field of Chinese medicines, particularly a kind of Chinese medicine for the treatment of ankylosing spondylitis.

Background technology

Ankylosing spondylitis is that one mainly invades spinal column, and involves the chronic progressive external inflammatory diseases of sacroiliac joint and periarticular, has another name called Marie-str ü mpell disease, Von Bechterew disease, poker back, rheumatoid centre type etc.Ankylosing spondylitis have certain hereditary basis.The traditional Chinese medical science is thought, the morbidity of ankylosing spondylitis arises from the not enough or imbalance of taking good care of oneself the day after tomorrow of natural endowment, sexual overstrain, terrified, disgruntled, lack of proper care after being ill, then cause caused by liver and kidney deficiency, in addition wind-cold damp pathogen and falling ill.

Ankylosing spondylitis onset is many at 15 ~ 30 years old, child and more than 40 years old person rare, and mostly be male.Ankylosing spondylitis insidious onset, makes slow progress, and General Symptoms is lighter.Early stage often to have back pain and morning to rise stiff, alleviates after activity, and can with low grade fever, weak, loss of appetite, the symptom such as to become thin.Originally pain is intermittent, and develop into rest pain gradually afterwards, then inflammatory pain fades away, and spinal column is from bottom to top some or all of tetanic, occurs bow-backed deformity.

At present, the medicament categories such as conventional antiinflammatory analgesia, immune formulation, hormone for the treatment of ankylosing spondylitis is a lot, but mostly cannot fundamentally treat, can only alleviating pain and complication to a certain extent, and some drugs is to health toxic side effect, long-term taking can cause very large infringement to stomach, liver, kidney etc.

Summary of the invention

The present invention, in order to make up the defect of prior art, provides a kind of determined curative effect, significantly, the Chinese medicine for the treatment of ankylosing spondylitis without any side effects.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine for ankylosing spondylitis, it is characterized in that: be made up of the medical material of following parts by weight:

Herba Epimedii 30 ~ 35 parts, the Cortex Eucommiae 15 ~ 20 parts, Herba Taxilli 15 ~ 20 parts, Rhizoma Cibotii 15 ~ 20 parts, Radix Achyranthis Bidentatae 12 ~ 15 parts, Radix Rehmanniae Preparata 15 ~ 20 parts, Radix Angelicae Sinensis 12 ~ 15 parts, the Radix Paeoniae Alba 12 ~ 15 parts, Ramulus Cinnamomi 10 ~ 12 parts, Rhizoma Chuanxiong 10 ~ 12 parts, RADIX SALVIAE MILTIORRHIZAE 15 ~ 20 parts, the Radix Astragali 20 ~ 25 parts, Caulis Piperis Kadsurae 10 ~ 12 parts, Pheretima 10 ~ 12 parts, Zaocys 10 ~ 12 parts, Olibanum 6 ~ 9 parts, Myrrha 6 ~ 9 parts, 6 ~ 9 parts, Radix Glycyrrhizae.

The present invention treats the Chinese medicine of ankylosing spondylitis, and preferred version is: be made up of the medical material of following parts by weight:

Herba Epimedii 32 parts, the Cortex Eucommiae 17 parts, Herba Taxilli 17 parts, Rhizoma Cibotii 17 parts, Radix Achyranthis Bidentatae 13 parts, Radix Rehmanniae Preparata 17 parts, Radix Angelicae Sinensis 13 parts, the Radix Paeoniae Alba 13 parts, Ramulus Cinnamomi 11 parts, Rhizoma Chuanxiong 11 parts, RADIX SALVIAE MILTIORRHIZAE 17 parts, the Radix Astragali 22 parts, Caulis Piperis Kadsurae 11 parts, Pheretima 11 parts, Zaocys 11 parts, Olibanum 7 parts, Myrrha 7 parts, 7 parts, Radix Glycyrrhizae.

Instructions of taking: be decocted in water for oral dose, every day 1 dose, divides and takes for 2 times, each 200ml.

Be the function and effect of each medical material in the present invention below:

Herba Epimedii: acrid in the mouth, sweet; Warm in nature; Return kidney, Liver Channel.There is kidney invigorating and YANG supporting, strengthening the tendons and bones, the effect of expelling wind and removing dampness.Cure mainly: impotence and seminal emission, cold caused by deficiency is sterile, frequent micturition incontinence, dyspnea and cough due to deficiency of the kidney, soreness of the waist and knees, rheumatic arthralgia, and hemiplegia, extremity are meciless.

The Cortex Eucommiae: sweet in the mouth, micro-pungent; Warm in nature; Return liver, kidney channel.There is invigorating the liver and kidney, bone and muscle strengthening, and antiabortive effect.Cure mainly: soreness of waist and knee joint, sexual impotence, frequent micturition, dribbling urination, rheumatic arthralgia, frequent fetal movement, and habitual abortion etc.

Herba Taxilli: bitter in the mouth, sweet; Property is put down; Return kidney, Liver Channel.Can invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive.Cure mainly: soreness of waist and knee joint, muscles and bones flaccidity is weak, and limbs are hemiplegia, rheumatic arthralgia, and Light-headedness is had blood in stool, frequent fetal movement, metrostaxis, lack of lactation after delivery.

Rhizoma Cibotii: bitter in the mouth, sweet; Warm in nature.There is strong waist knee joint, the effect in wind-damp dispelling and sharp joint.Cure mainly: lumbago due to renal deficiency machine gun, sufficient knee joint weakness, rheumatic arthralgia, urine is too much, seminal emission, women's leukorrhagia.

Radix Achyranthis Bidentatae: bitter in the mouth, acid; Property is put down; Return kidney, Liver Channel.There is invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, draw blood (fire) descending, effect of inducing diuresis for treating stranguria syndrome.Cure mainly: soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, dysmenorrhea, puerperal abdominal pain due to blood stasis, retention of placenta, pyretic stranguria, stranguria with blood, traumatic injury, carbuncle malignant boil, laryngopharynx swelling and pain.

Radix Rehmanniae Preparata: sweet in the mouth; Warm in nature; Return kidney, Liver Channel.Have YIN nourishing of enriching blood, beneficial essence fills out the effect of marrow.Cure mainly: blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, metrorrhagia is more than, hepatic and renal YIN deficiency, hectic fever night sweat, and seminal emission sexual impotence, infertility, soreness of the waist and knees, Hiccough and deaf, the head is dim-sighted, early whitening of beard and hair, quenches one's thirst, constipation, dyspnea with rapid and short breath of suffering from a deficiency of the kidney.

Radix Angelicae Sinensis: sweet in the mouth, pungent, bitter; Warm in nature; Return liver, the heart, spleen channel.Can enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation.Cure mainly: all diseases of blood deficiency, menoxenia, amenorrhea, dysmenorrhea, metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, heavy after bloody dysentery, ulcer sores, injury from falling down etc.

The Radix Paeoniae Alba: bitter in the mouth, acid; Cold nature; Return spleen, Liver Channel.Can nourish blood and seek, relieving spasm to stop pain, yin fluid astringing suppressing the hyperactive liver.Cure mainly: blood deficiency cold and heat, epigastric pain, hypochondriac pain, limb spasm pain, dysmenorrhea, menoxenia, metrorrhagia, spontaneous perspiration, night sweat, dysentery is had loose bowels, and has a headache dizzy.

Ramulus Cinnamomi: acrid in the mouth, sweet; Warm in nature; Return bladder, the heart, lung meridian.There is expelling cold and relieving exterior syndrome, warming the meridian, the effect of activating yang.Cure mainly: exterior syndrome due to wind-cold, arthralgia due to cold-dampnes, extreme cold of the limbs, amenorrhea dysmenorrhea, the thoracic obstruction, cardiopalmus, phlegm retention, dysuria etc.

Rhizoma Chuanxiong: acrid in the mouth; Warm in nature; Return liver, gallbladder, pericardium channel.There is blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, the effect of wind-expelling pain-stopping.Cure mainly: menoxenia, amenorrhea dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, pain in chest and hypochondrium, has a headache dizzy, anemofrigid-damp arthralgia, traumatic injury, ulcer sores etc.

RADIX SALVIAE MILTIORRHIZAE: puckery, micro-hardship; Cool in nature.There is invigorating the kidney and strengthening the bones, the effect of promoting blood circulation and hemostasis.Cure mainly: lumbago due to renal deficiency, rheumatalgia, menoxenia, dysmenorrhea, amenorrhea, metrorrhagia, have blood in stool, spit blood, traumatic injury becomes silted up bitterly, and knife injury is hemorrhage.

The Radix Astragali: sweet in the mouth; Warm in nature; Return lung, spleen channel.Can benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening.Cure mainly the disease of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, non-void cough, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle difficulty is burst or is burst for a long time and do not hold back.

Caulis Piperis Kadsurae: bitter in the mouth; Cold in nature; GUIXIN, lung meridian.There is wind-damp dispelling, the meridian dredging, effect of regulating QI to relieve pain.Cure mainly: anemofrigid-damp arthralgia, arthrodynia of extremities, the contracture of muscle arteries and veins, coldness and pain in the epigastrium, edema etc.

Pheretima: salty in the mouth; Cold in nature; Return liver, lung, kidney channel.There is relieving convulsion, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., dredging collateral, the effect of relievining asthma.Cure mainly: calentura heating is manic, infantile convulsion is twitched, headache due to hyperactivity of liver-YANG, conjunctival congestion and swelling pain, apoplectic hemiplegia, rheumatic arthralgia, childhood inguinal hernia disease, dyspnea and cough due to lung-heat, pharyngitis, urinary obstruction.

Zaocys: sweet in the mouth; Property is put down; Return liver, lung, spleen channel.Can wind-damp dispelling, the meridian dredging, relieving convulsion.Cure mainly: rheumatoid arthritis stubborn, numbness of the skin, the contracture of muscle arteries and veins, quadriplegia, tetanus, leprosy, rubella scabies.

Olibanum: acrid in the mouth, hardship; Warm in nature; GUIXIN, liver, spleen channel.Have and invigorate blood circulation, circulation of qi promoting, the effect of pain relieving.Cure mainly: trusted subordinate's pain, amenorrhea, dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, traumatic injury becomes silted up bitterly, swollen ulcer drug, the sore being festered and unhealed.

Myrrha: bitter in the mouth; Property is put down; GUIXIN, liver, spleen channel.There is blood stasis dispelling, detumescence, effect of pain relieving.Cure mainly: breast is suffered from abdominal pain, dysmenorrhea, amenorrhea, treating swelling and pain by traumatic injury, carbuncle skin infection, conjunctival congestion and swelling pain etc.

Radix Glycyrrhizae: sweet in the mouth; Property is put down; Return spleen, stomach, the heart, lung meridian.Can with middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Raw with curing mainly: laryngopharynx swelling and pain, carbuncle pyogenic infections from tumour or sore, infantile carbuncle and medicine, alimentary toxicosis.Process with curing mainly: weakness of the spleen and stomach, tired state lack of appetite, stomachache loose stool, the anxious pain of extremity contraction, cardiopalmus, hysteria, consumptive lung disease is coughed.

Beneficial effect of the present invention: Chinese medicine gained decoction treatment ankylosing spondylitis effective percentage of the present invention is up to 94.7%, for caused by liver and kidney deficiency, insufficiency of vital energy and blood, governor vessel loses supports caused all kinds of arthromyodynia determined curative effects, significantly, without any side effects, there is temperature and superintend and direct the kidney invigorating, promoting blood circulation, dredging meridian and relieving pain, effect of dispelling cold and dehumidification.

Detailed description of the invention

Embodiment 1:

Prescription: Herba Epimedii 30g, Cortex Eucommiae 15g, Herba Taxilli 15g, Rhizoma Cibotii 15g, Radix Achyranthis Bidentatae 12g, Radix Rehmanniae Preparata 15g, Radix Angelicae Sinensis 12g, Radix Paeoniae Alba 12g, Ramulus Cinnamomi 10g, Rhizoma Chuanxiong 10g, RADIX SALVIAE MILTIORRHIZAE 15g, Radix Astragali 20g, Caulis Piperis Kadsurae 10g, Pheretima 10g, Zaocys 10g, Olibanum 6g, Myrrha 6g, Radix Glycyrrhizae 6g.

Instructions of taking: be decocted in water for oral dose, every day 1 dose, divides and takes for 2 times, each 200ml.

Embodiment 2:

Prescription: Herba Epimedii 32g, Cortex Eucommiae 17g, Herba Taxilli 17g, Rhizoma Cibotii 17g, Radix Achyranthis Bidentatae 13g, Radix Rehmanniae Preparata 17g, Radix Angelicae Sinensis 13g, Radix Paeoniae Alba 13g, Ramulus Cinnamomi 11g, Rhizoma Chuanxiong 11g, RADIX SALVIAE MILTIORRHIZAE 17g, Radix Astragali 22g, Caulis Piperis Kadsurae 11g, Pheretima 11g, Zaocys 11g, Olibanum 7g, Myrrha 7g, Radix Glycyrrhizae 7g.

Instructions of taking: be decocted in water for oral dose, every day 1 dose, divides and takes for 2 times, each 200ml.

Embodiment 3:

Prescription: Herba Epimedii 35g, Cortex Eucommiae 20g, Herba Taxilli 20g, Rhizoma Cibotii 20g, Radix Achyranthis Bidentatae 15g, Radix Rehmanniae Preparata 20g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 15g, Ramulus Cinnamomi 12g, Rhizoma Chuanxiong 12g, RADIX SALVIAE MILTIORRHIZAE 20g, Radix Astragali 25g, Caulis Piperis Kadsurae 12g, Pheretima 12g, Zaocys 12g, Olibanum 9g, Myrrha 9g, Radix Glycyrrhizae 9g.

Instructions of taking: be decocted in water for oral dose, every day 1 dose, divides and takes for 2 times, each 200ml.

Embodiment 4: clinical observation

One, clinical data and instructions of taking

Random selecting patients with ankylosing spondylitis 1200 example, is decocted in water for oral dose Chinese medicine of the present invention, and every day 1 dose, divide and take for 2 times, each 200ml was 1 course for the treatment of with 1 month.

Two, efficacy assessment standard

Cure: heavy stiff transference cure, sacroiliac joint and each symptoms of joint pain disappear, and arthroncus disappears, and freely, each joint positive sign disappears joint motion, and each joint physiological function recovers normal.

Effective: heavy stiff symptom is clearly better, and sacroiliac joint and each symptoms of joint pain are clearly better, and arthroncus is clearly better, and joint motion obviously improves, and each joint positive sign is clearly better, and each joint physiological function is obviously recovered.

Effective: heavy stiff symptom takes a turn for the better, sacroiliac joint and each symptoms of joint pain take a turn for the better, and arthroncus takes a turn for the better, and joint motion improves, and each joint positive sign alleviates, and each joint physiological function is improved.

Invalid: heavy stiff symptom is without improvement, and sacroiliac joint and each symptoms of joint pain are without improvement, and arthroncus is unchanged, and joint motion is without improvement, and each joint positive sign is without improvement, and each joint physiological function is unchanged.

Three, therapeutic outcome

Take gained decoction of the present invention effective for 1 ~ 3 course for the treatment of, there are positive effect 5 ~ 6 courses for the treatment of, and 10 ~ 12 courses for the treatment of can cure.1200 routine patient's cure rates are 57.7%, and obvious effective rate is 25.5%, and effective percentage is 11.5%, and total effective rate reaches 94.7%.

Four, model case

Case one: Gong Xiangjun, man, 28 years old, peasant.First visit on the 10th in 03 month in 2009.

Patient, because of waist and sacrum pain recurrent exerbation more than a year, increases the weight of 1 week to examine.Occur waist and sacrum pain without obvious inducement the year before, be that very after activity of getting up, symptom alleviates or disappears, and owing to not affecting work and life, and does not arouse attention before rising morning.Above-mentioned exacerbation of symptoms before nearly 1 week, and occur that double knee joint swells and ache, limitation of activity, night stands up difficulty, and morning is obviously stiff, persistent period is greater than 1 hour, and carry on the back cold, time overcast and rainy, pain increases the weight of, and obtains warm alleviation of pain, with soreness of the waist and knees, fatigue and asthenia, two just adjust, and pale tongue is dark, white and thin fur, deep-thready pulse.Lab testing: HLA-B27 is positive, ESR36mm/h.Sacroiliac joint CT sheet shows: meet sacroiliitis (II level) and change.Western medicine diagnose: ankylosing spondylitis.Tcm diagnosis: arthromyodynia, belongs to caused by liver and kidney deficiency, cold-dampness numbness.Control with liver and kidney tonifying, dispelling cold and removing dampness dredging collateral.Give decoction of the present invention sooner or later each oral medication, take medicine after 21 doses, morning is stiff, and waist and sacrum pain, stands up difficulty night and double knee joint pain symptom obviously alleviates, and conscious right hips is ached, and pale tongue is dark, white and thin fur, deep-thready pulse.Following the service after 8 months morning deadlock, waist and sacrum pain, night stands up difficulty and double knee joint swells and ache, right hips aches transference cure, only feels the swollen discomfort of lumbosacral region acid, fatigue and asthenia.

Case two: Liu Qinghe, man, 36 years old, peasant.First visit on October 06 in 2010.

Patient's aching pain in waist and back 3 years, companion's left lower extremity pain, numb 1 year, patient's 3 years causes get injured by a fall lumbosacral region, and feel the stiff pain of psoas muscle after diseases caused by exogenous pathogenic factor rheumatism, light night in daytime is heavy, increases the weight of gradually, morning stiff time 20-30 minute.Examine and see: lumbar spine activity is restricted that slight left side is curved, spinal column and sacral joint tenderness, pelvic compression and the separation test positive; Red tongue, yellow and greasy fur, slippery and rapid pulse.At blood test Lactoferrin 98g/l, erythrocyte sedimentation rate 32mm/1h, rheumatoid factor (-).X-ray shows: zygapophyseal joint gap is fuzzy, disappearance, calcification that posterior longitudinal ligament is slight; Articular surface hardens, gap is crude, the visible cystis degeneration in left side, and under joint, 1/3 ligament calcification is obvious.Diagnosis: ankylosing spondylitis.Treatment is with decoction of the present invention, and after serveing on 21 doses, lumbago and skelalgia is obviously alleviated; Continue and take 30 doses, patient's subjective symptoms disappears, movable as usual, rear decoction after treatment of the present invention 6 months.Follow up a case by regular visits to 2 years, stable curative effect.

Case three: Li Yuzhu, man, 32 years old, peasant.First visit on the 15th in 06 month in 2011.

Patient's private prosecution lumbosacral pain more than 3 years, the two knee joint of companion, capped elbow pain, can not squat down, dysstasia, bend over to stand up limitation of activity, walk difficult.Examine and see: the tetanic shape of spinal column, light red tongue, tongue are white thick greasy, stringy and hesitant pulse.ESR erythrocyte sedimentation rate 102mm/h.X line shows: sacral joint narrows.Be diagnosed as ankylosing spondylitis.Give decoction oral of the present invention treatment.Further consultation after medication 15 doses, symptom alleviates, and can walk and stand.After continuing to take 6 months, transference cure, functional rehabilitation.Check ESR:12mm/h.Rear decoction oral of the present invention is with consolidate curative effect.Visit 2 years without recurrence.

Claims (2)

1. treat a Chinese medicine for ankylosing spondylitis, it is characterized in that: be made up of the medical material of following parts by weight:

Herba Epimedii 30 ~ 35 parts, the Cortex Eucommiae 15 ~ 20 parts, Herba Taxilli 15 ~ 20 parts, Rhizoma Cibotii 15 ~ 20 parts, Radix Achyranthis Bidentatae 12 ~ 15 parts, Radix Rehmanniae Preparata 15 ~ 20 parts, Radix Angelicae Sinensis 12 ~ 15 parts, the Radix Paeoniae Alba 12 ~ 15 parts, Ramulus Cinnamomi 10 ~ 12 parts, Rhizoma Chuanxiong 10 ~ 12 parts, RADIX SALVIAE MILTIORRHIZAE 15 ~ 20 parts, the Radix Astragali 20 ~ 25 parts, Caulis Piperis Kadsurae 10 ~ 12 parts, Pheretima 10 ~ 12 parts, Zaocys 10 ~ 12 parts, Olibanum 6 ~ 9 parts, Myrrha 6 ~ 9 parts, 6 ~ 9 parts, Radix Glycyrrhizae.

2. the Chinese medicine for the treatment of ankylosing spondylitis according to claim 1, is characterized in that: be made up of the medical material of following parts by weight:

Herba Epimedii 32 parts, the Cortex Eucommiae 17 parts, Herba Taxilli 17 parts, Rhizoma Cibotii 17 parts, Radix Achyranthis Bidentatae 13 parts, Radix Rehmanniae Preparata 17 parts, Radix Angelicae Sinensis 13 parts, the Radix Paeoniae Alba 13 parts, Ramulus Cinnamomi 11 parts, Rhizoma Chuanxiong 11 parts, RADIX SALVIAE MILTIORRHIZAE 17 parts, the Radix Astragali 22 parts, Caulis Piperis Kadsurae 11 parts, Pheretima 11 parts, Zaocys 11 parts, Olibanum 7 parts, Myrrha 7 parts, 7 parts, Radix Glycyrrhizae.