CN101428096A - Chinese medicinal composition for treating femoral head necrosis and preparation method thereof - Google Patents
Chinese medicinal composition for treating femoral head necrosis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating osteonecrosis of the femoral head and a preparation method thereof. The traditional Chinese medicine composition is a medicament which is prepared by ginseng, membranous milkvetch root, Szechuan lovage rhizome, red paeony root, divaricate saposhnikovia root, suberect spatholobus stem, medicinal cyathula root, radix rehmanniae preparata, peach seed, safflower, sanchi, barbary wolfberry fruit, Chinese angelica, prepared common monkshood daughter root, deer horn gelatin, ephedra herb, stir-fried white mustard seed, epimedium herb, prepared common monkshood mother root, prepared kusnezoff monkshood root, scorpion, centipede, prepared frankincense, prepared myrrh, Szechwan Chinaberry fruit, ground beetle, native copper, dragon's blood and other medicines by the conventional pharmaceutical process. The invention has the advantages that the traditional Chinese medicine composition has special formula, exact efficacy, safety, economy, no obvious toxicity or side effects and effects of activating blood circulation, removing blood stasis, tonifying liver and kidney, strengthening spleen, benefiting qi, strengthening tendon and bone, dispelling pathogenic wind and dampness, dredging channels and relieving pain, thereby being applicable to patients with the osteonecrosis of the femoral head for administration.
Description
One, technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of femur head necrosis and preparation method thereof.
Two, background technology
Femur head necrosis full name aseptic necrosis of femoral head, or ischemic necrosis of femoral head are that the local blood fortune of femoral head that causes owing to multiple reason is bad, thereby cause a kind of pathological changes of the further ischemia of osteocyte, necrosis, bone trabecula fracture, collapse of the femoral head.Clinical manifestation is that pain, intermittent claudication, collapse of the femoral head, joint space narrow down, and can cause osteoarthritis and cause joint function disturbance at last.The patient of whole world trouble femur head necrosis has 3,000 ten thousand people approximately at present, and China has 4,000,000 people approximately.Slow owing to this course of disease, pathogenesis is complicated, low one of the worldwide difficult and complicated illness that is put into of cure rate.Up-to-date investigation shows, this disease do not have an obvious sex difference, any age all can be ill, and had hormone to use the probability showed increased of history, hip trauma history, excessive drinking history, relevant disease history person morbidity.Modern medicine thinks that the femur head necrosis commonly encountered diseases is following several because of having: (1) wound: as fracture of the femoral head, and dislocation of hip joint, femoral head compression injury etc.(2) because of the long-term a large amount of hormonal medicaments that use of certain disease.(3) long-term excessive drinking, congenital hip dysplasia, humidity etc.This disease does not have special Therapeutic Method at present, and mainly take conservative treatment, late period then to adopt artificial replacement's art early stage.Modern study show have invigorating the kidney and strengthening the bones, the Chinese medicine of function of promoting blood circulation to disperse blood clots has certain curative effect to femur head necrosis, can improve femur head necrosis local intra-arterial blood supply dysfunction, strengthen regional blood flow, promote bone trabecula regeneration to form, cryptomere changes dwindles, sclerotic bone absorbs, and repair at the cartilage position, and the unobstructed vessel amyotrophy recovers.
The traditional Chinese medical science think with femur head necrosis pathological changes relation the closest for liver,spleen,kidney three dirty.The kidney being the origin of congenital constitution, and main bone is given birth to marrow, and the strong then marrow of kidney fills, and marrow is the bone heavily fortified point completely then; Otherwise then the marrow dry bones withers, and loses the regeneration capacity of application.The liver governing tendons store blood, with the kidney homology, two dirty honor decline together, if liver gets involved, store blood mistake department can not the normal regulating blood volume, nutrition is not good, also is the key factor that causes ischemia femur head necrosis.Taste be the day after tomorrow this, all things on earth the source of vital function, spleen is good for the stomach and, then paddy is not become thoroughly decomposed, activating QI blood is defended with the field headquarters, if taste lose strong fortune, biochemical QI and blood is passive, then muscles and bones muscle all depletion of QI with life.
The traditional Chinese medical science think femur head necrosis pathological changes main diseases due to illness machine the following aspects is arranged:
1, violence is hindered: owing to extraneous violence, wound cause the lighter's skin and flesh impaired, weight person's organizational structure is destroyed fracture, and the stasis of blood is stagnant suddenly to make QI and blood, disorder of QI movement checks venation, and venation is obstructed, qi depression to blood stasis, the femoral head local blood is supplied with and is obstructed, thereby femur head necrosis takes place.With the passing of time violence is hindered and is not healed, and involves Liver and kidney, caused by liver and kidney deficiency, and asthenia of essence and blood, bone is become homeless foster, generation femur head necrosis of a specified duration.
2, six climate exopathogens are hindered: wind-cold damp pathogen is hindered, and mainly is to experience the cold-damp heresy, and the heresy of cold-damp is containing, insufficiency of kidney-YANG, and deficient qi and blood, qi depression to blood stasis is due to exopathogen is attacked.Yang-energy is obstructed, and QI and blood is agitated unable, and QI-blood circulation is not smooth, and the resistance of venation numbness is obstructed, and bone is become homeless foster, and qi depression to blood stasis, the mistake of muscle arteries and veins is supported, wins in the YANG QI deficiency, YIN-cold, and coagulation of QI-blood, not warm extremity, sending out is femur head necrosis.
3, evil poison is hindered: evil poison is the poison of medicine, invades in the malicious heresy, and the Liver and kidney spleen is impaired, and the function disorder causes the ascending or descending movement of vital Qi functional disorder, deficiency of both the liver and kidney of a specified duration.Liver governing tendons, kidney governing bones, muscles and bones links to each other, and is to close outside the Liver and kidney, and liver blood is full, and muscles and bones must support that then function of joint is normal.The prolonged illness kidney is got involved, and insufficiency of kidney-YANG, spleen lose in warm, the biochemical weary source of QI and blood, and osteogenesis is unfavorable.Because the interdependence between yin and yang alternate, insufficiency of kidney-YANG, the moon are refined to give birth to and are had no way of, and cause the cloudy damage of essence void of Liver and kidney, thus QI and blood deficiency, deficiency of the liver and kindey, the brain inanition, the bone of suffering from a deficiency of the kidney then withered and need not, osteoporosis of a specified duration.Deficiency of spleen-QI, no resource of generating and transforming QI and blood, muscle contracture, joint stuffiness, the femur head necrosis that then takes place of a specified duration.Studies confirm that long-term a large amount of hormones that use can cause immunologic hypofunction in the body, cause insufficiency of kidney-YANG, are easy to bring out primary disease.
4, natural endowment deficiency: congenital congenital deficiency, deficiency of both the liver and kidney, the femoral head epiphyseal dysplasia is easy to necrosis, or acetabular dysplasia, and femoral head contains not enough, all can cause femur head necrosis.
5, the day after tomorrow, mistake was supported: the foundation of acquired constitution is spleen, and the congenital foundation is kidney, the transformation and transportation of the spleen and stomach imbalance, and essence of water and grain is not given birth to, be difficult to moisten foster body, congenital kidney essense can not get day after tomorrow essence of water and grain and supplements nutrition, then deficiency of kidney-essence, the kidney generating marrow and dominating bone, the deficiency of kidney-essence bone is become homeless foster, and femur head necrosis easily takes place.
6, impairment caused by overstrain is excessive: impairment caused by overstrain is excessive, injures QI and blood, and insufficiency of vital energy and blood, muscle arteries and veins skeleton lose to be supported, and extremity bones of the body collectively and function of joint activity all rely moistens fosterly in QI and blood warm, and femoral head can not get abundant blood supply, also can cause osteoporosis, easily sends out femur head necrosis.
In sum, it is considered herein that the femur head necrosis pathological changes no matter the cause of disease why, its pathogenesis is the most key with stagnation of QI-blood, caused by liver and kidney deficiency, for this reason, with blood circulation promoting and blood stasis dispelling, nourishing the liver and kidney, invigorating the spleen and benefiting QI, the strong muscle of bone strengthening is that method is founded we, and clinical use is achieved good results.The present invention adopts pure Chinese medicine formulated, has characteristics such as determined curative effect, safety, no obvious toxic-side effects.
Three, summary of the invention
The object of the present invention is to provide the Chinese medicine composition and preparation method thereof of the treatment femur head necrosis of a kind of determined curative effect, safety, economy, no obvious toxic-side effects, be applicable to that the femur head necrosis patient takes.
Technical scheme of the present invention: a kind of Chinese medicine composition for the treatment of femur head necrosis is by Radix Ginseng, the Radix Astragali, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Saposhnikoviae, Caulis Spatholobi, Radix Cyathulae, Radix Rehmanniae Preparata, Semen Persicae, Flos Carthami, Radix Notoginseng, Fructus Lycii, Radix Angelicae Sinensis, Radix Aconiti Lateralis Preparata, Colla cornus cervi, Herba Ephedrae, Semen Sinapis Albae (parched), Herba Epimedii, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Scorpio, Scolopendra, Olibanum (processed), Myrrha (processed), Fructus Toosendan, Eupolyphaga Seu Steleophaga (eupolyphaga), Pyritum, medicines such as Sanguis Draxonis are made, and it is characterized in that it being the medicament that is prepared from by following raw material composition and weight proportion: 10～60 parts of Radix Ginsengs, 50～150 parts of the Radixs Astragali, 10～60 parts of Rhizoma Chuanxiongs, 20～80 parts of Radix Paeoniae Rubra, 20～80 parts of Radix Saposhnikoviaes, 50～150 parts of Caulis Spatholobis, 30～120 parts of Radix Cyathulaes, 50～150 parts of Radix Rehmanniae Preparata, 10～60 parts in Semen Persicae, 10～60 parts on Flos Carthami, 10～60 parts of Radix Notoginseng, 10～60 parts of Fructus Lyciis, 10～70 parts of Radix Angelicae Sinensis, 10～70 parts of Radix Aconiti Lateralis Preparata, 50～150 parts of Colla cornus cervis, 10～60 parts in Herba Ephedrae, 10～60 parts of Semen Sinapis Albae (parched), 50～150 parts of Herba Epimedii, 10～60 parts of Radix Aconiti Preparatas, 10～60 parts of Radix Aconiti Kusnezoffii Preparatas, 20～80 parts of Scorpios, 10～60 parts of Scolopendras, 5～30 parts of Olibanum (processed)s, 5～30 parts of Myrrha (processed)s, 10～60 parts of Fructus Toosendans, 20～80 parts of Eupolyphaga Seu Steleophagas, 5～30 parts of Pyritums, 5～50 parts of Sanguis Draxonis.
Preferred weight ratio range of the present invention is: 20～50 parts of Radix Ginsengs, 70～130 parts of the Radixs Astragali, 20～50 parts of Rhizoma Chuanxiongs, 30～70 parts of Radix Paeoniae Rubra, 30～70 parts of Radix Saposhnikoviaes, 70～130 parts of Caulis Spatholobis, 50～100 parts of Radix Cyathulaes, 70～130 parts of Radix Rehmanniae Preparata, 20～50 parts in Semen Persicae, 15～50 parts on Flos Carthami, 20～50 parts of Radix Notoginseng, 20～50 parts of Fructus Lyciis, 20～60 parts of Radix Angelicae Sinensis, 20～60 parts of Radix Aconiti Lateralis Preparata, 70～130 parts of Colla cornus cervis, 15～50 parts in Herba Ephedrae, 20～50 parts of Semen Sinapis Albae (parched), 70～130 parts of Herba Epimedii, 20～50 parts of Radix Aconiti Preparatas, 20～50 parts of Radix Aconiti Kusnezoffii Preparatas, 30～70 parts of Scorpios, 20～50 parts of Scolopendras, 8～20 parts of Olibanum (processed)s, 8～20 parts of Myrrha (processed)s, 15～50 parts of Fructus Toosendans, 30～70 parts of Eupolyphaga Seu Steleophagas, 8～20 parts of Pyritums, 8～30 parts of Sanguis Draxonis.
Optimum weight ratio range of the present invention is: 30 parts of Radix Ginsengs, 100 parts of the Radixs Astragali, 30 parts of Rhizoma Chuanxiongs, 50 parts of Radix Paeoniae Rubra, 50 parts of Radix Saposhnikoviaes, 100 parts of Caulis Spatholobis, 70 parts of Radix Cyathulaes, 100 parts of Radix Rehmanniae Preparata, 30 parts in Semen Persicae, 20 parts on Flos Carthami, 30 parts of Radix Notoginseng, 30 parts of Fructus Lyciis, 40 parts of Radix Angelicae Sinensis, 40 parts of Radix Aconiti Lateralis Preparata, 100 parts of Colla cornus cervis, 20 parts in Herba Ephedrae, 30 parts of Semen Sinapis Albae (parched), 100 parts of Herba Epimedii, 30 parts of Radix Aconiti Preparatas, 30 parts of Radix Aconiti Kusnezoffii Preparatas, 50 parts of Scorpios, 30 parts of Scolopendras, 10 parts of Olibanum (processed)s, 10 parts of Myrrha (processed)s, 20 parts of Fructus Toosendans, 50 parts of Eupolyphaga Seu Steleophagas, 10 parts of Pyritums, 20 parts of Sanguis Draxonis.
A kind of preparation method for the treatment of the Chinese medicine composition of femur head necrosis is characterized in that it is the medicament that adopts conventional pharmaceutical technology to make, and comprises following oral liquid, powder, pill, granule, capsule, tablets and other formulations.
Wherein, when oral liquid prepares, press recipe quantity above each crude drug water is decocted 1～3 time, filter, merging filtrate is made oral liquid.
When powder prepares, press recipe quantity, cross 80～100 mesh sieves, pack, promptly above each crude drug oven dry, pulverizing.
When pill prepares, press recipe quantity, cross 80～100 mesh sieves above each crude drug oven dry, pulverizing, system water pill such as Semen Raphani size, dry below 80 ℃, packing, promptly.
When granule prepares, press recipe quantity above each crude drug water is decocted 2～3 times, filter, merging filtrate is evaporated to fluid extract, oven dry is pulverized, and crosses 80～100 mesh sieves, behind 0.3～0.5% dextrin mixing, with 70～90% ethanol is wetting agent, makes granule, packing, promptly.
When capsule prepares, press recipe quantity above each crude drug water is decocted 2～3 times, filter, merging filtrate is evaporated to fluid extract, oven dry is pulverized, and crosses 80～100 mesh sieves, behind 0.3～0.5% dextrin mixing, with 70～90% ethanol is wetting agent, makes granule, encapsulated, promptly.
During preparation tablets, press recipe quantity above each crude drug water is decocted 2～3 times, filter, merging filtrate is evaporated to fluid extract, oven dry, pulverize, cross 80～100 mesh sieves, behind 0.3～0.5% dextrin mixing, with 70～90% ethanol is wetting agent, make granule, add 0.1～0.3% magnesium stearate or 0.3～0.5% differential silica gel, tabletting, packing, promptly.
The invention has the advantages that the prescription uniqueness, determined curative effect, safety, economy, no obvious toxic-side effects have the effect of blood circulation promoting and blood stasis dispelling, nourishing the liver and kidney, invigorating the spleen and benefiting QI, the strong muscle of bone strengthening, expelling wind and dampness, removing obstruction in the collateral to relieve pain, are applicable to that the femur head necrosis patient takes.
Clinical treatment 30 routine femur head necrosis patients of the present invention achieve good results.30 routine patients are modern medicine and are diagnosed as femur head necrosis, male's 17 examples wherein, women's 13 examples; 22～65 years old age, average 43.5 years old.
Therapeutic Method: oral 3～9g, 2～3 times on the one, 3 months was 1 course of treatment, on average used 5 courses of treatment; Not absolute arresting method is adopted in Primary Care, alleviates heavy burden, strengthens functional exercise, in order to avoid cause the useless property used calcium deficiency.
Efficacy assessment standard divides 4 grades: (1) cures (clinical cure): clinical symptoms disappears or complete obiteration substantially, and function of joint is basic normal or normal fully.X-ray film shows that bone density is even, and bone trabecula reproduces, and the necrotic area cystis degeneration dwindles or disappears, and the joint space is normal.(2) produce effects: pain relief or disappearance, basic or most of recovery of function of joint.X-ray film shows that bone density is comparatively even, and the necrotic area cystis degeneration dwindles or do not have and increase the weight of, and bone trabecula reappears, and the joint space is normal.(3) effective: clinical symptom relief, function of joint improves.X-ray film shows that the necrotic area cystis degeneration is controlled.(4) invalid: clinical symptoms does not have bright improvement, the function commentaries on classics of not getting better.X-ray film shows necrotic area cystis degeneration's no change or increases the weight of.
Therapeutic outcome: cure 24 examples, account for 80%; Produce effects 3 examples account for 10%; Effective 2 examples account for 6.67%, and invalid 1 example accounts for 3.33%; Total effective rate 96.67%.Do not see obvious toxic-side effects during the clinical observation.
Clinical treatment 30 routine femur head necrosis patient's curative effect situations of the present invention
Four, the specific embodiment
With specific embodiment the present invention is elaborated below:
Embodiment 1:
Take by weighing raw material according to following proportioning: 20 parts of Radix Ginsengs, 60 parts of the Radixs Astragali, 30 parts of Rhizoma Chuanxiongs, 30 parts of Radix Paeoniae Rubra, 30 parts of Radix Saposhnikoviaes, 60 parts of Caulis Spatholobis, 40 parts of Radix Cyathulaes, 60 parts of Radix Rehmanniae Preparata, 20 parts in Semen Persicae, 20 parts on Flos Carthami, 20 parts of Radix Notoginseng, 20 parts of Fructus Lyciis, 20 parts of Radix Angelicae Sinensis, 20 parts of Radix Aconiti Lateralis Preparata, 60 parts of Colla cornus cervis, 20 parts in Herba Ephedrae, 20 parts of Semen Sinapis Albae (parched), 60 parts of Herba Epimedii, 20 parts of Radix Aconiti Preparatas, 20 parts of Radix Aconiti Kusnezoffii Preparatas, 30 parts of Scorpios, 20 parts of Scolopendras, 10 parts of Olibanum (processed)s, 10 parts of Myrrha (processed)s, 20 parts of Fructus Toosendans, 30 parts of Eupolyphaga Seu Steleophagas, 10 parts of Pyritums, 10 parts of Sanguis Draxonis.
Preparation method: the medicament that adopts conventional pharmaceutical technology to make comprises following oral liquid, powder, pill, granule, capsule, tablets and other formulations.
Embodiment 2:
Take by weighing raw material according to following proportioning: 50 parts of Radix Ginsengs, 140 parts of the Radixs Astragali, 50 parts of Rhizoma Chuanxiongs, 70 parts of Radix Paeoniae Rubra, 70 parts of Radix Saposhnikoviaes, 130 parts of Caulis Spatholobis, 110 parts of Radix Cyathulaes, 140 parts of Radix Rehmanniae Preparata, 50 parts in Semen Persicae, 50 parts on Flos Carthami, 50 parts of Radix Notoginseng, 50 parts of Fructus Lyciis, 60 parts of Radix Angelicae Sinensis, 60 parts of Radix Aconiti Lateralis Preparata, 140 parts of Colla cornus cervis, 50 parts in Herba Ephedrae, 50 parts of Semen Sinapis Albae (parched), 140 parts of Herba Epimedii, 50 parts of Radix Aconiti Preparatas, 50 parts of Radix Aconiti Kusnezoffii Preparatas, 70 parts of Scorpios, 50 parts of Scolopendras, 20 parts of Olibanum (processed)s, 20 parts of Myrrha (processed)s, 50 parts of Fructus Toosendans, 70 parts of Eupolyphaga Seu Steleophagas, 20 parts of Pyritums, 40 parts of Sanguis Draxonis.
Preparation method: the medicament that adopts conventional pharmaceutical technology to make comprises following oral liquid, powder, pill, granule, capsule, tablets and other formulations.
Embodiment 3:
Take by weighing raw material according to following proportioning: 30 parts of Radix Ginsengs, 100 parts of the Radixs Astragali, 30 parts of Rhizoma Chuanxiongs, 50 parts of Radix Paeoniae Rubra, 50 parts of Radix Saposhnikoviaes, 100 parts of Caulis Spatholobis, 70 parts of Radix Cyathulaes, 100 parts of Radix Rehmanniae Preparata, 30 parts in Semen Persicae, 20 parts on Flos Carthami, 30 parts of Radix Notoginseng, 30 parts of Fructus Lyciis, 40 parts of Radix Angelicae Sinensis, 40 parts of Radix Aconiti Lateralis Preparata, 100 parts of Colla cornus cervis, 20 parts in Herba Ephedrae, 30 parts of Semen Sinapis Albae (parched), 100 parts of Herba Epimedii, 30 parts of Radix Aconiti Preparatas, 30 parts of Radix Aconiti Kusnezoffii Preparatas, 50 parts of Scorpios, 30 parts of Scolopendras, 10 parts of Olibanum (processed)s, 10 parts of Myrrha (processed)s, 20 parts of Fructus Toosendans, 50 parts of Eupolyphaga Seu Steleophagas, 10 parts of Pyritums, 20 parts of Sanguis Draxonis.
Preparation method: the medicament that adopts conventional pharmaceutical technology to make comprises following oral liquid, powder, pill, granule, capsule, tablets and other formulations.
Embodiment 4: the oral liquid preparation
Take by weighing raw material according to following proportioning: 30 parts of Radix Ginsengs, 100 parts of the Radixs Astragali, 30 parts of Rhizoma Chuanxiongs, 50 parts of Radix Paeoniae Rubra, 50 parts of Radix Saposhnikoviaes, 100 parts of Caulis Spatholobis, 70 parts of Radix Cyathulaes, 100 parts of Radix Rehmanniae Preparata, 30 parts in Semen Persicae, 20 parts on Flos Carthami, 30 parts of Radix Notoginseng, 30 parts of Fructus Lyciis, 40 parts of Radix Angelicae Sinensis, 40 parts of Radix Aconiti Lateralis Preparata, 100 parts of Colla cornus cervis, 20 parts in Herba Ephedrae, 30 parts of Semen Sinapis Albae (parched), 100 parts of Herba Epimedii, 30 parts of Radix Aconiti Preparatas, 30 parts of Radix Aconiti Kusnezoffii Preparatas, 50 parts of Scorpios, 30 parts of Scolopendras, 10 parts of Olibanum (processed)s, 10 parts of Myrrha (processed)s, 20 parts of Fructus Toosendans, 50 parts of Eupolyphaga Seu Steleophagas, 10 parts of Pyritums, 20 parts of Sanguis Draxonis.
Preparation method: press recipe quantity above each crude drug water is decocted 1～3 time, filter, merging filtrate is made oral liquid.
Embodiment 5: the powder preparation
Take by weighing raw material according to following proportioning: 30 parts of Radix Ginsengs, 100 parts of the Radixs Astragali, 30 parts of Rhizoma Chuanxiongs, 50 parts of Radix Paeoniae Rubra, 50 parts of Radix Saposhnikoviaes, 100 parts of Caulis Spatholobis, 70 parts of Radix Cyathulaes, 100 parts of Radix Rehmanniae Preparata, 30 parts in Semen Persicae, 20 parts on Flos Carthami, 30 parts of Radix Notoginseng, 30 parts of Fructus Lyciis, 40 parts of Radix Angelicae Sinensis, 40 parts of Radix Aconiti Lateralis Preparata, 100 parts of Colla cornus cervis, 20 parts in Herba Ephedrae, 30 parts of Semen Sinapis Albae (parched), 100 parts of Herba Epimedii, 30 parts of Radix Aconiti Preparatas, 30 parts of Radix Aconiti Kusnezoffii Preparatas, 50 parts of Scorpios, 30 parts of Scolopendras, 10 parts of Olibanum (processed)s, 10 parts of Myrrha (processed)s, 20 parts of Fructus Toosendans, 50 parts of Eupolyphaga Seu Steleophagas, 10 parts of Pyritums, 20 parts of Sanguis Draxonis.
Preparation method: press recipe quantity with above each crude drug oven dry, pulverizing, cross 80～100 mesh sieves, pack, promptly.
Embodiment 6: the pill preparation
Take by weighing raw material according to following proportioning: 30 parts of Radix Ginsengs, 100 parts of the Radixs Astragali, 30 parts of Rhizoma Chuanxiongs, 50 parts of Radix Paeoniae Rubra, 50 parts of Radix Saposhnikoviaes, 100 parts of Caulis Spatholobis, 70 parts of Radix Cyathulaes, 100 parts of Radix Rehmanniae Preparata, 30 parts in Semen Persicae, 20 parts on Flos Carthami, 30 parts of Radix Notoginseng, 30 parts of Fructus Lyciis, 40 parts of Radix Angelicae Sinensis, 40 parts of Radix Aconiti Lateralis Preparata, 100 parts of Colla cornus cervis, 20 parts in Herba Ephedrae, 30 parts of Semen Sinapis Albae (parched), 100 parts of Herba Epimedii, 30 parts of Radix Aconiti Preparatas, 30 parts of Radix Aconiti Kusnezoffii Preparatas, 50 parts of Scorpios, 30 parts of Scolopendras, 10 parts of Olibanum (processed)s, 10 parts of Myrrha (processed)s, 20 parts of Fructus Toosendans, 50 parts of Eupolyphaga Seu Steleophagas, 10 parts of Pyritums, 20 parts of Sanguis Draxonis.
Preparation method: press recipe quantity with above each crude drug oven dry, pulverizing, cross 80～100 mesh sieves, system water pill such as Semen Raphani size, dry below 80 ℃, packing, promptly.
Embodiment 7: the granule preparation
Take by weighing raw material according to following proportioning: 30 parts of Radix Ginsengs, 100 parts of the Radixs Astragali, 30 parts of Rhizoma Chuanxiongs, 50 parts of Radix Paeoniae Rubra, 50 parts of Radix Saposhnikoviaes, 100 parts of Caulis Spatholobis, 70 parts of Radix Cyathulaes, 100 parts of Radix Rehmanniae Preparata, 30 parts in Semen Persicae, 20 parts on Flos Carthami, 30 parts of Radix Notoginseng, 30 parts of Fructus Lyciis, 40 parts of Radix Angelicae Sinensis, 40 parts of Radix Aconiti Lateralis Preparata, 100 parts of Colla cornus cervis, 20 parts in Herba Ephedrae, 30 parts of Semen Sinapis Albae (parched), 100 parts of Herba Epimedii, 30 parts of Radix Aconiti Preparatas, 30 parts of Radix Aconiti Kusnezoffii Preparatas, 50 parts of Scorpios, 30 parts of Scolopendras, 10 parts of Olibanum (processed)s, 10 parts of Myrrha (processed)s, 20 parts of Fructus Toosendans, 50 parts of Eupolyphaga Seu Steleophagas, 10 parts of Pyritums, 20 parts of Sanguis Draxonis.
Preparation method: press recipe quantity above each crude drug water is decocted 2～3 times, filter, merging filtrate is evaporated to fluid extract, oven dry is pulverized, and crosses 80 mesh sieves, behind 0.3～0.5% dextrin mixing, with 70～90% ethanol is wetting agent, makes granule, packing, promptly.
Embodiment 8: the capsule preparation
Take by weighing raw material according to following proportioning: 30 parts of Radix Ginsengs, 100 parts of the Radixs Astragali, 30 parts of Rhizoma Chuanxiongs, 50 parts of Radix Paeoniae Rubra, 50 parts of Radix Saposhnikoviaes, 100 parts of Caulis Spatholobis, 70 parts of Radix Cyathulaes, 100 parts of Radix Rehmanniae Preparata, 30 parts in Semen Persicae, 20 parts on Flos Carthami, 30 parts of Radix Notoginseng, 30 parts of Fructus Lyciis, 40 parts of Radix Angelicae Sinensis, 40 parts of Radix Aconiti Lateralis Preparata, 100 parts of Colla cornus cervis, 20 parts in Herba Ephedrae, 30 parts of Semen Sinapis Albae (parched), 100 parts of Herba Epimedii, 30 parts of Radix Aconiti Preparatas, 30 parts of Radix Aconiti Kusnezoffii Preparatas, 50 parts of Scorpios, 30 parts of Scolopendras, 10 parts of Olibanum (processed)s, 10 parts of Myrrha (processed)s, 20 parts of Fructus Toosendans, 50 parts of Eupolyphaga Seu Steleophagas, 10 parts of Pyritums, 20 parts of Sanguis Draxonis.
Preparation method: press recipe quantity above each crude drug water is decocted 2～3 times, filter, merging filtrate is evaporated to fluid extract, oven dry is pulverized, and crosses 80 mesh sieves, behind 0.3～0.5% dextrin mixing, with 70～90% ethanol is wetting agent, makes granule, encapsulated, promptly.
Embodiment 9: preparation tablets
Take by weighing raw material according to following proportioning: 30 parts of Radix Ginsengs, 100 parts of the Radixs Astragali, 30 parts of Rhizoma Chuanxiongs, 50 parts of Radix Paeoniae Rubra, 50 parts of Radix Saposhnikoviaes, 100 parts of Caulis Spatholobis, 70 parts of Radix Cyathulaes, 100 parts of Radix Rehmanniae Preparata, 30 parts in Semen Persicae, 20 parts on Flos Carthami, 30 parts of Radix Notoginseng, 30 parts of Fructus Lyciis, 40 parts of Radix Angelicae Sinensis, 40 parts of Radix Aconiti Lateralis Preparata, 100 parts of Colla cornus cervis, 20 parts in Herba Ephedrae, 30 parts of Semen Sinapis Albae (parched), 100 parts of Herba Epimedii, 30 parts of Radix Aconiti Preparatas, 30 parts of Radix Aconiti Kusnezoffii Preparatas, 50 parts of Scorpios, 30 parts of Scolopendras, 10 parts of Olibanum (processed)s, 10 parts of Myrrha (processed)s, 20 parts of Fructus Toosendans, 50 parts of Eupolyphaga Seu Steleophagas, 10 parts of Pyritums, 20 parts of Sanguis Draxonis.
Preparation method: press recipe quantity above each crude drug water is decocted 2～3 times, filter merging filtrate, be evaporated to fluid extract, oven dry is pulverized, cross 80 mesh sieves, behind 0.3～0.5% dextrin mixing, be wetting agent with 70～90% ethanol, make granule, add 0.1～0.3% magnesium stearate or 0.3～0.5% differential silica gel, tabletting, packing, promptly.
Claims (10)
1, a kind of Chinese medicine composition for the treatment of femur head necrosis is characterized in that it being the medicament that is prepared from by following raw material composition and weight proportion: 10～60 parts of Radix Ginsengs, 50～150 parts of the Radixs Astragali, 10～60 parts of Rhizoma Chuanxiongs, 20～80 parts of Radix Paeoniae Rubra, 20～80 parts of Radix Saposhnikoviaes, 50～150 parts of Caulis Spatholobis, 30～120 parts of Radix Cyathulaes, 50～150 parts of Radix Rehmanniae Preparata, 10～60 parts in Semen Persicae, 10～60 parts on Flos Carthami, 10～60 parts of Radix Notoginseng, 10～60 parts of Fructus Lyciis, 10～70 parts of Radix Angelicae Sinensis, 10～70 parts of Radix Aconiti Lateralis Preparata, 50～150 parts of Colla cornus cervis, 10～60 parts in Herba Ephedrae, 10～60 parts of Semen Sinapis Albae (parched), 50～150 parts of Herba Epimedii, 10～60 parts of Radix Aconiti Preparatas, 10～60 parts of Radix Aconiti Kusnezoffii Preparatas, 20～80 parts of Scorpios, 10～60 parts of Scolopendras, 5～30 parts of Olibanum (processed)s, 5～30 parts of Myrrha (processed)s, 10～60 parts of Fructus Toosendans, 20～80 parts of Eupolyphaga Seu Steleophagas, 5～50 parts of 5～30 parts of Pyritums and Sanguis Draxonis.
2, as claims 1 described a kind of Chinese medicine composition for the treatment of femur head necrosis, it is characterized in that weight proportion is: 20～50 parts of Radix Ginsengs, 70～130 parts of the Radixs Astragali, 20～50 parts of Rhizoma Chuanxiongs, 30～70 parts of Radix Paeoniae Rubra, 30～70 parts of Radix Saposhnikoviaes, 70～130 parts of Caulis Spatholobis, 50～100 parts of Radix Cyathulaes, 70～130 parts of Radix Rehmanniae Preparata, 20～50 parts in Semen Persicae, 15～50 parts on Flos Carthami, 20～50 parts of Radix Notoginseng, 20～50 parts of Fructus Lyciis, 20～60 parts of Radix Angelicae Sinensis, 20～60 parts of Radix Aconiti Lateralis Preparata, 70～130 parts of Colla cornus cervis, 15～50 parts in Herba Ephedrae, 20～50 parts of Semen Sinapis Albae (parched), 70～130 parts of Herba Epimedii, 20～50 parts of Radix Aconiti Preparatas, 20～50 parts of Radix Aconiti Kusnezoffii Preparatas, 30～70 parts of Scorpios, 20～50 parts of Scolopendras, 8～20 parts of Olibanum (processed)s, 8～20 parts of Myrrha (processed)s, 15～50 parts of Fructus Toosendans, 30～70 parts of Eupolyphaga Seu Steleophagas, 8～30 parts of 8～20 parts of Pyritums and Sanguis Draxonis.
3, as claims 1 described a kind of Chinese medicine composition for the treatment of femur head necrosis, it is characterized in that weight proportion is: 30 parts of Radix Ginsengs, 100 parts of the Radixs Astragali, 30 parts of Rhizoma Chuanxiongs, 50 parts of Radix Paeoniae Rubra, 50 parts of Radix Saposhnikoviaes, 100 parts of Caulis Spatholobis, 70 parts of Radix Cyathulaes, 100 parts of Radix Rehmanniae Preparata, 30 parts in Semen Persicae, 20 parts on Flos Carthami, 30 parts of Radix Notoginseng, 30 parts of Fructus Lyciis, 40 parts of Radix Angelicae Sinensis, 40 parts of Radix Aconiti Lateralis Preparata, 100 parts of Colla cornus cervis, 20 parts in Herba Ephedrae, 30 parts of Semen Sinapis Albae (parched), 100 parts of Herba Epimedii, 30 parts of Radix Aconiti Preparatas, 30 parts of Radix Aconiti Kusnezoffii Preparatas, 50 parts of Scorpios, 30 parts of Scolopendras, 10 parts of Olibanum (processed)s, 10 parts of Myrrha (processed)s, 20 parts of Fructus Toosendans, 50 parts of Eupolyphaga Seu Steleophagas, 20 parts of 10 parts of Pyritums and Sanguis Draxonis.
4, as claims 1,2 or 3 described a kind of Chinese medicine compositions for the treatment of femur head necrosis, it is characterized in that it is oral liquid, powder, pill, granule, capsule or tablet.
5, as claims 4 described oral liquids, when it is characterized in that oral liquid prepares, get 10～60 parts of Radix Ginsengs, 50～150 parts of the Radixs Astragali, 10～60 parts of Rhizoma Chuanxiongs, 20～80 parts of Radix Paeoniae Rubra, 20～80 parts of Radix Saposhnikoviaes, 50～150 parts of Caulis Spatholobis, 30～120 parts of Radix Cyathulaes, 50～150 parts of Radix Rehmanniae Preparata, 10～60 parts in Semen Persicae, 10～60 parts on Flos Carthami, 10～60 parts of Radix Notoginseng, 10～60 parts of Fructus Lyciis, 10～70 parts of Radix Angelicae Sinensis, 10～70 parts of Radix Aconiti Lateralis Preparata, 50～150 parts of Colla cornus cervis, 10～60 parts in Herba Ephedrae, 10～60 parts of Semen Sinapis Albae (parched), 50～150 parts of Herba Epimedii, 10～60 parts of Radix Aconiti Preparatas, 10～60 parts of Radix Aconiti Kusnezoffii Preparatas, 20～80 parts of Scorpios, 10～60 parts of Scolopendras, 5～30 parts of Olibanum (processed)s, 5～30 parts of Myrrha (processed)s, 10～60 parts of Fructus Toosendans, 20～80 parts of Eupolyphaga Seu Steleophagas, 5～50 parts of 5～30 parts of Pyritums and Sanguis Draxonis; Above each crude drug water is decocted 1～3 time, filter, merging filtrate is made oral liquid.
6, as claims 4 described powders, when it is characterized in that powder prepares, get 10～60 parts of Radix Ginsengs, 50～150 parts of the Radixs Astragali, 10～60 parts of Rhizoma Chuanxiongs, 20～80 parts of Radix Paeoniae Rubra, 20～80 parts of Radix Saposhnikoviaes, 50～150 parts of Caulis Spatholobis, 30～120 parts of Radix Cyathulaes, 50～150 parts of Radix Rehmanniae Preparata, 10～60 parts in Semen Persicae, 10～60 parts on Flos Carthami, 10～60 parts of Radix Notoginseng, 10～60 parts of Fructus Lyciis, 10～70 parts of Radix Angelicae Sinensis, 10～70 parts of Radix Aconiti Lateralis Preparata, 50～150 parts of Colla cornus cervis, 10～60 parts in Herba Ephedrae, 10～60 parts of Semen Sinapis Albae (parched), 50～150 parts of Herba Epimedii, 10～60 parts of Radix Aconiti Preparatas, 10～60 parts of Radix Aconiti Kusnezoffii Preparatas, 20～80 parts of Scorpios, 10～60 parts of Scolopendras, 5～30 parts of Olibanum (processed)s, 5～30 parts of Myrrha (processed)s, 10～60 parts of Fructus Toosendans, 20～80 parts of Eupolyphaga Seu Steleophagas, 5～50 parts of 5～30 parts of Pyritums and Sanguis Draxonis; With above each crude drug oven dry, pulverizing, cross 80～100 mesh sieves, pack, promptly.
7, as claims 4 described pills, when it is characterized in that pill prepares, get 10～60 parts of Radix Ginsengs, 50～150 parts of the Radixs Astragali, 10～60 parts of Rhizoma Chuanxiongs, 20～80 parts of Radix Paeoniae Rubra, 20～80 parts of Radix Saposhnikoviaes, 50～150 parts of Caulis Spatholobis, 30～120 parts of Radix Cyathulaes, 50～150 parts of Radix Rehmanniae Preparata, 10～60 parts in Semen Persicae, 10～60 parts on Flos Carthami, 10～60 parts of Radix Notoginseng, 10～60 parts of Fructus Lyciis, 10～70 parts of Radix Angelicae Sinensis, 10～70 parts of Radix Aconiti Lateralis Preparata, 50～150 parts of Colla cornus cervis, 10～60 parts in Herba Ephedrae, 10～60 parts of Semen Sinapis Albae (parched), 50～150 parts of Herba Epimedii, 10～60 parts of Radix Aconiti Preparatas, 10～60 parts of Radix Aconiti Kusnezoffii Preparatas, 20～80 parts of Scorpios, 10～60 parts of Scolopendras, 5～30 parts of Olibanum (processed)s, 5～30 parts of Myrrha (processed)s, 10～60 parts of Fructus Toosendans, 20～80 parts of Eupolyphaga Seu Steleophagas, 5～50 parts of 5～30 parts of Pyritums and Sanguis Draxonis; With above each crude drug oven dry, pulverizing, cross 80～100 mesh sieves, system water pill such as Semen Raphani size, dry below 80 ℃, packing, promptly.
8, as claims 4 described granules, when it is characterized in that granule prepares, get 10～60 parts of Radix Ginsengs, 50～150 parts of the Radixs Astragali, 10～60 parts of Rhizoma Chuanxiongs, 20～80 parts of Radix Paeoniae Rubra, 20～80 parts of Radix Saposhnikoviaes, 50～150 parts of Caulis Spatholobis, 30～120 parts of Radix Cyathulaes, 50～150 parts of Radix Rehmanniae Preparata, 10～60 parts in Semen Persicae, 10～60 parts on Flos Carthami, 10～60 parts of Radix Notoginseng, 10～60 parts of Fructus Lyciis, 10～70 parts of Radix Angelicae Sinensis, 10～70 parts of Radix Aconiti Lateralis Preparata, 50～150 parts of Colla cornus cervis, 10～60 parts in Herba Ephedrae, 10～60 parts of Semen Sinapis Albae (parched), 50～150 parts of Herba Epimedii, 10～60 parts of Radix Aconiti Preparatas, 10～60 parts of Radix Aconiti Kusnezoffii Preparatas, 20～80 parts of Scorpios, 10～60 parts of Scolopendras, 5～30 parts of Olibanum (processed)s, 5～30 parts of Myrrha (processed)s, 10～60 parts of Fructus Toosendans, 20～80 parts of Eupolyphaga Seu Steleophagas, 5～50 parts of 5～30 parts of Pyritums and Sanguis Draxonis; Above each crude drug water is decocted 2～3 times, filter, merging filtrate is evaporated to fluid extract, and oven dry is pulverized, and crosses 80～100 mesh sieves, behind 0.3～0.5% dextrin mixing, is wetting agent with 70～90% ethanol, makes granule, packing, promptly.
9, as claims 4 described capsules, when it is characterized in that capsule prepares, get 10～60 parts of Radix Ginsengs, 50～150 parts of the Radixs Astragali, 10～60 parts of Rhizoma Chuanxiongs, 20～80 parts of Radix Paeoniae Rubra, 20～80 parts of Radix Saposhnikoviaes, 50～150 parts of Caulis Spatholobis, 30～120 parts of Radix Cyathulaes, 50～150 parts of Radix Rehmanniae Preparata, 10～60 parts in Semen Persicae, 10～60 parts on Flos Carthami, 10～60 parts of Radix Notoginseng, 10～60 parts of Fructus Lyciis, 10～70 parts of Radix Angelicae Sinensis, 10～70 parts of Radix Aconiti Lateralis Preparata, 50～150 parts of Colla cornus cervis, 10～60 parts in Herba Ephedrae, 10～60 parts of Semen Sinapis Albae (parched), 50～150 parts of Herba Epimedii, 10～60 parts of Radix Aconiti Preparatas, 10～60 parts of Radix Aconiti Kusnezoffii Preparatas, 20～80 parts of Scorpios, 10～60 parts of Scolopendras, 5～30 parts of Olibanum (processed)s, 5～30 parts of Myrrha (processed)s, 10～60 parts of Fructus Toosendans, 20～80 parts of Eupolyphaga Seu Steleophagas, 5～50 parts of 5～30 parts of Pyritums and Sanguis Draxonis; Above each crude drug water is decocted 2～3 times, filter, merging filtrate is evaporated to fluid extract, and oven dry is pulverized, and crosses 80～100 mesh sieves, behind 0.3～0.5% dextrin mixing, is wetting agent with 70～90% ethanol, makes granule, and is encapsulated, promptly.
10, as claims 4 described tablets, when it is characterized in that preparation tablets, get 10～60 parts of Radix Ginsengs, 50～150 parts of the Radixs Astragali, 10～60 parts of Rhizoma Chuanxiongs, 20～80 parts of Radix Paeoniae Rubra, 20～80 parts of Radix Saposhnikoviaes, 50～150 parts of Caulis Spatholobis, 30～120 parts of Radix Cyathulaes, 50～150 parts of Radix Rehmanniae Preparata, 10～60 parts in Semen Persicae, 10～60 parts on Flos Carthami, 10～60 parts of Radix Notoginseng, 10～60 parts of Fructus Lyciis, 10～70 parts of Radix Angelicae Sinensis, 10～70 parts of Radix Aconiti Lateralis Preparata, 50～150 parts of Colla cornus cervis, 10～60 parts in Herba Ephedrae, 10～60 parts of Semen Sinapis Albae (parched), 50～150 parts of Herba Epimedii, 10～60 parts of Radix Aconiti Preparatas, 10～60 parts of Radix Aconiti Kusnezoffii Preparatas, 20～80 parts of Scorpios, 10～60 parts of Scolopendras, 5～30 parts of Olibanum (processed)s, 5～30 parts of Myrrha (processed)s, 10～60 parts of Fructus Toosendans, 20～80 parts of Eupolyphaga Seu Steleophagas, 5～50 parts of 5～30 parts of Pyritums and Sanguis Draxonis; Above each crude drug water is decocted 2～3 times, filter merging filtrate, be evaporated to fluid extract, oven dry is pulverized, cross 80～100 mesh sieves, behind 0.3～0.5% dextrin mixing, be wetting agent with 70～90% ethanol, make granule, add 0.1～0.3% magnesium stearate or 0.3～0.5% differential silica gel, tabletting, packing, promptly.
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Cited By (9)
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| CN101816705A (en) * | 2010-04-23 | 2010-09-01 | 四平市中西医结合医院 | Medicine for treating femoral head necrosis by three-needle injection and fumigation and preparation method thereof |
| CN101698020B (en) * | 2009-10-28 | 2011-08-31 | 韦标方 | Traditional Chinese medicine preparation for treating femoral head necrosis and preparation method thereof |
| CN102764355A (en) * | 2012-08-13 | 2012-11-07 | 于明儒 | Traditional Chinese medicine composite for curing femoral head necrosis |
| CN103520663A (en) * | 2013-08-28 | 2014-01-22 | 李新民 | Formula for treating femoral head osteonecrosis |
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| CN100345571C (en) * | 2004-12-20 | 2007-10-31 | 李德民 | Medication for treating necrosis of femoral head and preparation method |
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| CN101698020B (en) * | 2009-10-28 | 2011-08-31 | 韦标方 | Traditional Chinese medicine preparation for treating femoral head necrosis and preparation method thereof |
| CN101816705A (en) * | 2010-04-23 | 2010-09-01 | 四平市中西医结合医院 | Medicine for treating femoral head necrosis by three-needle injection and fumigation and preparation method thereof |
| CN101816705B (en) * | 2010-04-23 | 2012-02-22 | 四平市中西医结合医院 | Medicine for treating femoral head necrosis by three-needle injection and fumigation and preparation method thereof |
| CN102764355A (en) * | 2012-08-13 | 2012-11-07 | 于明儒 | Traditional Chinese medicine composite for curing femoral head necrosis |
| CN102764355B (en) * | 2012-08-13 | 2015-02-04 | 于明儒 | Traditional Chinese medicine composite for curing femoral head necrosis |
| CN103520663A (en) * | 2013-08-28 | 2014-01-22 | 李新民 | Formula for treating femoral head osteonecrosis |
| CN103585316A (en) * | 2013-11-12 | 2014-02-19 | 王宗理 | Stasis-removing and pain-relieving powder for treating pain and preparation method of powder |
| CN104127620A (en) * | 2014-07-22 | 2014-11-05 | 乔立峰 | Traditional Chinese medicinal preparation for treating femur head necrosis |
| CN104826026A (en) * | 2015-05-23 | 2015-08-12 | 济南邦文医药科技有限公司 | Medicine for treating middle and later-period femoral head necrosis caused by liver and kidney deficiency and intermin-gled phlegm and blood stasis |
| CN108404038A (en) * | 2017-02-09 | 2018-08-17 | 林峰 | A kind of turbid bone Chinese medicine compositions living of promoting blood circulation of Wen Yanghua treating avascular necrosis of femoral head |
| CN108404038B (en) * | 2017-02-09 | 2020-12-29 | 林畅 | Traditional Chinese medicine composition for treating femoral head ischemic necrosis, warming yang, eliminating turbidity, dredging collaterals and activating bones |
| CN110934983A (en) * | 2019-12-31 | 2020-03-31 | 宗吉红 | Traditional Chinese medicine composition for treating bone arthralgia syndrome and preparation method thereof |
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