CN108404038B - Traditional Chinese medicine composition for treating femoral head ischemic necrosis, warming yang, eliminating turbidity, dredging collaterals and activating bones - Google Patents
Traditional Chinese medicine composition for treating femoral head ischemic necrosis, warming yang, eliminating turbidity, dredging collaterals and activating bones Download PDFInfo
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- CN108404038B CN108404038B CN201710071688.6A CN201710071688A CN108404038B CN 108404038 B CN108404038 B CN 108404038B CN 201710071688 A CN201710071688 A CN 201710071688A CN 108404038 B CN108404038 B CN 108404038B
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Abstract
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine for warming yang, eliminating turbidity, dredging collaterals and activating bones for treating ischemic necrosis of femoral head. The traditional Chinese medicine is prepared from the following raw materials: 6g of deerhorn glue, 30g of astragalus, 20g of codonopsis pilosula, 20g of centipede, 2 pieces of ground beetle, 10g of radix aconiti lateralis preparata, 5g of cassia twig, 10g of white mustard seed, 10g of ephedra, 5g of ligusticum wallichii, 20g of prepared rehmannia root, 10g of epimedium, 20g of rhizoma polygonati, 20g of angelica, 6g of vinegar-treated curcuma zedoary, 10g of prepared bitter orange, 10g of radix bupleuri, 10g of radix curcuma. The traditional Chinese medicine has an obvious effect of treating ischemic necrosis of femoral head and has no toxic or side effect.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating femoral head ischemic necrosis, warming yang, eliminating turbidity, dredging collaterals and activating bones.
Background
Avascular necrosis of the femoral head occurs due to blood supply disturbance of femoral head histiocyte caused by various reasons such as vascular embolism and bone marrow lesion. For the avascular necrosis of the femoral head in the middle and early stages, a head protection treatment scheme is generally selected firstly, and the commonly used methods of surgical treatment include medullary core decompression, various bone transplants and osteotomies. It can be seen that the restoration of blood supply function of blood vessel is the core of the treatment of avascular necrosis of the femoral head. However, how to eliminate various reasons causing femoral head vascular embolism by non-operative treatment, recover the vascular patency and revive the femoral head bone with ischemic necrosis remains a clinical treatment difficulty. The theory of Suzhou & Yin-Yang correspondence is that the theory of Yang accumulation is day, Yin accumulation is earth, Yin is calm and Yang is restless, Yang grows into Yin, Yang kills Yin and stores Yin, Yang regulates Qi and Yin is formed. In combination with clinical practice, the pathogenesis of femoral head necrosis is that the femoral head is caused by deficiency of yang and qi and phlegm stasis blocking channels, and the treatment is performed by warming yang, dissolving turbidity and dredging channels. When yang qi is abundant, phlegm will be dispersed, so that the blood vessel will be unobstructed and the bone will be alive. The early clinical tests prove that the preparation can grasp the fundamental link of the ischemic necrosis of the femoral head, can effectively recover the blood supply of the ischemic necrosis femoral head, obviously improve the functions of bones and joints of the ischemic necrosis femoral head, has no toxic or side effect, is an ideal Chinese medicinal preparation for treating the ischemic necrosis of the femoral head, and has wide application prospect and huge social and economic benefits.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating ischemic necrosis of femoral head, which has the advantages of obvious effect on treating ischemic necrosis of femoral head and no toxic or side effect.
In order to achieve the purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine composition for treating avascular necrosis of femoral head, which has the effects of warming yang, eliminating turbidity, dredging collaterals and activating bones, is prepared from the following raw materials in parts by weight:
3-20g of deerhorn glue, 10-60g of astragalus root, 10-30g of codonopsis pilosula, 1-4 g of centipede, 5-20g of ground beetle, 3-10g of aconitum carmichaeli, 5-15g of cassia twig, 5-15g of white mustard seed, 3-15 g of ephedra, 3-10g of ligusticum wallichii, 5-20g of prepared rehmannia root, 10-30g of epimedium, 5-15g of rhizoma polygonati, 10-40g of angelica sinensis, 3-10g of vinegar-processed curcuma zedoary, 5-20g of prepared bitter orange, 3-10g of radix glycyrrhizae, 5-20g of radix curcumae, 5-20g of radix bupleuri, 2.
Preferably colla cornus cerviMelting by heat6g of astragalus root, 30g of codonopsis pilosula, 20g of centipede, 2 ground beeltle and 10g of aconitum carmichaeliDecocting first5g of cassia twig 10g of white mustard seed 10g of ephedra 5g of chuanxiong rhizome 10g of prepared rehmannia root 20g of epimedium 10g of siberian solomonseal rhizome 20g of Chinese angelica root 6g of vinegar-processed zedoary 10g of prepared bitter orange 10g of licorice root 5g of bupleurum root 10g of curcuma root 10g of safflower 5g of tetrandra root 15g of moutan bark 10 g.
The preparation method of the traditional Chinese medicine for warming yang, eliminating turbidity, dredging collaterals and activating bones for treating the ischemic necrosis of the femoral head comprises the following steps:
(1) mixing the mixture and water according to the weight ratio of 1:5, and soaking in water for 30 minutes;
(2) decocting the mixture obtained in the step (1) and water for 90 minutes, and filtering to obtain a first filtrate and filter residue;
(3) mixing the filter residue obtained in the step (2) with water according to a weight ratio of 1:4, decocting for 60 minutes, filtering to obtain a second filtrate and filter residue, mixing the first filtrate and the second filtrate, and melting the antler glue into the mixed solution to obtain the decoction of the medicine.
The pharmacology and the effect of the invention are as follows:
the invention selects a plurality of traditional Chinese medicines such as antler glue, astragalus, codonopsis pilosula, centipede, 2 pieces of ground beetle, accessory piece, cassia twig, white mustard seed, ephedra, rhizome of rehmannia, epimedium, rhizoma polygonati, vinegar, zedoary, bitter orange, liquorice, radix bupleuri, radix curcumae, safflower, radix stephaniae tetrandrae, cortex moutan and the like to prepare the traditional Chinese.
Wherein, the antler glue can strengthen the primordial yang, warm the bones and muscles and benefit the essence and blood.
Bland radix Aconiti lateralis Preparata, reviving yang and rescuing from collapse; to warm and tonify the spleen and kidney.
Prepared rehmannia root, radix rehmanniae Praeparata, has the effects of enriching blood and nourishing yin; replenishing vital essence and marrow.
Herba Epimedii is effective in invigorating kidney yang, strengthening tendons and bones, and dispelling pathogenic wind and dampness.
Rhizoma Chuanxiong, moving qi; promoting blood circulation and removing blood stasis.
Huang Qi can tonify qi.
Codonopsis pilosula, radix Codonopsis, is effective in replenishing qi and invigorating spleen.
Angelica sinensis for enriching blood; promoting blood circulation; can be used for relieving pain.
Cassia twig, ramulus cinnamomi, expelling wind and removing cold; warming yang and dredging collaterals.
White mustard seed, phlegm-resolving and fluid retention-expelling; dissipate stagnation and relieve swelling.
Fang Ji has the actions of inducing diuresis to alleviate edema, dispelling wind and relieving pain.
Ma Huang is indicated for diaphoresis and exterior syndrome relieving.
Wu Gong, dispersing pathogenic wind and removing obstruction in the channels.
Eupolyphaga Seu Steleophaga, radix seu caulis Kadsurae Heteroclitae and radix seu caulis Kadsurae Heteroclitae.
Vinegar-Zedoariae rhizoma, radix Curcumae, breaks blood and moves qi.
Safflower, promotes blood circulation and unblocks the meridians.
Turmeric root-tuber, radix Curcumae, promoting blood circulation to arrest pain; move qi and relieve depression.
Cortex moutan, clearing heat; cooling the blood; dissipating blood stasis.
Rhizoma Polygonati for replenishing vital essence; strengthening the muscles and bones; benefiting essence.
Fructus Aurantii is processed to break qi, remove phlegm and resolve food stagnation.
Bupleurum root, radix bupleuri, dispersing the depressed liver-energy; relieving exterior syndrome and bringing down fever.
Licorice root, radix Glycyrrhizae can tonify the spleen and replenish qi, and harmonize the effects of the other drugs in the recipe.
The traditional Chinese medicine raw materials are decocted to prepare decoction, and the traditional Chinese medicine raw materials are used together to play the effect of warming yang to eliminate turbid pathogen and activating bones. Has obvious effect on treating the damage of central nervous function.
Clinical data:
in order to show the treatment effect of the medicine, the invention carries out systematic clinical research on 120 patients with ischemic necrosis of femoral head, and 120 cases are all from the affiliated orthopedics hospital of Guangzhou Chinese medicine university.
Treatment groups: 60 cases are selected according to the treatment sequence and a random number table method, all treatment medicines are stopped on the basis of the original treatment, and the medicine is simply taken for 6 months.
Control group: selecting 60 cases according to the random number table method according to the treatment sequence, and orally taking Xianlinggubao capsules for 6 months.
The difference between the two groups after statistical treatment has no statistical significance in the aspects of disease condition, sex, age, course of disease and the like.
The taking method comprises the following steps: treatment groups: 300 ml of decoction of the medicine is taken in the morning and at night every day, and the treatment course is 6 months. Control group: the Xianlinggubao capsule is orally taken 3 capsules each time, 2 times a day, 200ml of warm boiled water is taken after eating for half an hour in the morning and at night, and the treatment course is 6 months.
Observation indicators and methods
Refer to the standard of the guidelines for clinical research of new Chinese medicines and the standard of the curative effect of diagnosis of the disease symptoms of traditional Chinese medicine.
The treatment group has 60 cases, 15 cases are cured, 36 cases with obvious effect, 7 cases with effect and 2 cases with no effect, and the total effective rate is 96.67 percent; in the control group, 60 patients are cured, 16 patients are obviously treated, 10 patients are effectively treated and 33 patients are not effectively treated, and the total effective rate is 45.00%. The difference of the effective rates of the two groups has obvious statistical significance, and the treatment group is obviously superior to the control group.
Detailed Description
Example 1
A traditional Chinese medicine for treating avascular necrosis of femoral head, which has the effects of warming yang, eliminating turbidity, dredging collaterals and activating bones, is prepared from the following raw materials in parts by weight:
deer horn glueMelting by heat3g of astragalus root, 15g of codonopsis pilosula, 10g of centipede, 1 ground beeltle and 5g of aconitum carmichaeliDecocting first2g of cassia twig 5g of white mustard seed 5g of ephedra herb 2g of szechuan lovage rhizome 5g of prepared rehmannia root 10g of epimedium 5g of manyflower solomonseal rhizome 10g of Chinese angelica root 3g of vinegar zedoary 5g of prepared bitter orange5g of liquorice, 2g of radix bupleuri, 5g of radix curcumae, 2g of safflower, 10g of radix stephaniae tetrandrae and 5g of cortex moutan.
The preparation method of the traditional Chinese medicine for warming yang, eliminating turbidity, dredging collaterals and activating bones for treating the ischemic necrosis of the femoral head comprises the following steps:
(1) mixing the mixture and water according to the weight ratio of 1:5, and soaking in water for 30 minutes;
(2) decocting the mixture obtained in the step (1) and water for 90 minutes, and filtering to obtain a first filtrate and filter residue;
(3) mixing the filter residue obtained in the step (2) with water according to a weight ratio of 1:4, decocting for 60 minutes, filtering to obtain a second filtrate and filter residue, mixing the first filtrate and the second filtrate, and melting the antler glue into the mixed solution to obtain the decoction of the medicine.
Example 2
A warming yang and resolving turbidity dredging and activating blood circulation bone for femoral head ischemic necrosis is prepared from the following raw materials in parts by weight:
deer horn glueMelting by heat6g of astragalus root, 30g of codonopsis pilosula, 20g of centipede, 2 ground beeltle and 10g of aconitum carmichaeliDecocting first5g of cassia twig 10g of white mustard seed 10g of ephedra 5g of chuanxiong rhizome 10g of prepared rehmannia root 20g of epimedium 10g of siberian solomonseal rhizome 20g of Chinese angelica root 6g of vinegar-processed zedoary 10g of prepared bitter orange 10g of licorice root 5g of bupleurum root 10g of curcuma root 10g of safflower 5g of tetrandra root 15g of moutan bark 10 g.
The preparation method of the warming yang, eliminating turbidity, dredging collaterals and activating bone for treating femoral head ischemic necrosis comprises the following steps:
(1) mixing the mixture and water according to the weight ratio of 1:5, and soaking in water for 30 minutes;
(2) decocting the mixture obtained in the step (1) and water for 90 minutes, and filtering to obtain a first filtrate and filter residue;
(3) mixing the filter residue obtained in the step (2) with water according to a weight ratio of 1:4, decocting for 60 minutes, filtering to obtain a second filtrate and filter residue, mixing the first filtrate and the second filtrate, and melting the antler glue into the mixed solution to obtain the decoction of the medicine.
Example 3
A warming yang and resolving turbidity dredging and activating blood circulation bone for femoral head ischemic necrosis is prepared from the following raw materials in parts by weight:
deer horn glueMelting by heat12g of astragalus root, 60g of codonopsis pilosula, 40g of centipede, 2 ground beeltle and 20g of aconitum carmichaeliDecocting first10g of cassia twig 20g of white mustard seed 20g of ephedra 10g of chuanxiong rhizome 20g of prepared rehmannia root 40g of epimedium 20g of siberian solomonseal rhizome 40g of Chinese angelica root 12g of vinegar-processed zedoary 20g of prepared bitter orange 20g of licorice root 10g of bupleurum root 20g of curcuma root 20g of safflower 10g of tetrandra root 30g of tree peony bark 20 g.
The preparation method of the warming yang, eliminating turbidity, dredging collaterals and activating bone for treating femoral head ischemic necrosis comprises the following steps:
(1) mixing the mixture and water according to the weight ratio of 1:5, and soaking in water for 30 minutes;
(2) decocting the mixture obtained in the step (1) and water for 90 minutes, and filtering to obtain a first filtrate and filter residue;
(3) mixing the filter residue obtained in the step (2) with water according to a weight ratio of 1:4, decocting for 60 minutes, filtering to obtain a second filtrate and filter residue, mixing the first filtrate and the second filtrate, and melting the antler glue into the mixed solution to obtain the decoction of the medicine.
Typical cases
Case one: first diagnosis in Suzhou, female, age 29, and day 09/12 in 2015. The patients had suffered from left hip pain after trauma before 8 years, had limited movements, had no obvious cause of aggravation of left hip pain before 1 week, and had limited movements. The diagnosis is as follows: generally, the condition is good, the tongue is dark red, the coating is thin and white, and the pulse is wiry and thready. And (4) checking: the movement of the left hip joint is limited in all directions, the pressure pain in the left inguinal region is obvious, and the test is shown in a '4' shape (+). The muscle strength, the feeling and the peripheral blood circulation of the left lower limb are good, physiological reflex exists, and pathological signs are not led out. Auxiliary inspection: x-ray film: necrosis of left femoral head; MRI showed ischemic necrosis of left femoral head (stage 3-4); avascular necrosis of the right femoral head (stage 1). The applicant believes that the disease belongs to ischemic necrosis of femoral head caused by yang-qi deficiency and phlegm-turbidity stasis blocking channels and collaterals, and the treatment is performed by warming yang, resolving turbidity, dredging collaterals and activating bones. Prescription: deer horn glueMelting by heat6g of astragalus root, 30g of codonopsis pilosula and 20g centipede, 2 ground beetles and 10g aconitum carmichaeliDecocting first5g of cassia twig 10g of white mustard seed 10g of ephedra 5g of chuanxiong rhizome 10g of prepared rehmannia root 20g of epimedium 10g of siberian solomonseal rhizome 20g of Chinese angelica root 6g of vinegar-processed zedoary 10g of prepared bitter orange 10g of licorice root 5g of bupleurum root 10g of curcuma root 10g of safflower 5g of tetrandra root 15g of moutan bark 10 g. Decoct 6 doses, 1 dose daily, with water. And (3) after 9 months and 19 days: the pain and discomfort of the left hip are relieved earlier and kept on the upper part, and 6 doses are taken continuously. And (3) after-treatment in 26 days in 9 months: the discomfort of the left hip is obviously relieved, and the movement is obviously improved. A red tongue with thin and white coating and a weak pulse. The patient is kept on the upper part and continues to take the medicine for 1 month. The patients will be retested after 1 month, the pain of the left hip disappears, and the left hip can move. The above prescription is continued for half a year, and the left hip has no obvious pain and discomfort and can move. The left femoral head necrosis of the X-ray film is rechecked approximately as before; MRI showed ischemic necrosis of the left femoral head (stage 3); the right femoral head has no obvious ischemic necrosis.
Claims (2)
1. A traditional Chinese medicine composition for treating avascular necrosis of femoral head, which has the effects of warming yang, eliminating turbidity, dredging collaterals and activating bones, is characterized by being prepared from the following raw materials in parts by weight:
3-20g of deerhorn glue, 10-60g of astragalus root, 10-30g of codonopsis pilosula, 1-4 centipedes, 5-20g of ground beetle, 3-10g of radix aconiti lateralis preparata, 5-15g of cassia twig, 5-15g of semen brassicae, 3-10g of ephedra, 5-20g of ligusticum wallichii, 10-30g of prepared rehmannia root, 5-15g of epimedium herb, 10-40g of rhizoma polygonati, 3-10g of angelica, 5-20g of vinegar curcuma zedoary, 5-20g of prepared fructus aurantii, 3-10g of liquorice, 5-20g of radix bupleuri, 5-20g of radix curcumae, 2-20g of safflower, 5-30g of radix stephaniae tetrandrae and 5-20;
the preparation method comprises the following steps:
1) mixing the mixture and water according to the weight ratio of 1:5, and soaking in water for 30 minutes;
2) decocting the mixture obtained in the step 1) and water for 90 minutes, and filtering to obtain a first filtrate and filter residue;
3) mixing the filter residue obtained in the step 2) with water according to the weight ratio of 1:4, decocting for 60 minutes, filtering to obtain a second filtrate and filter residue, mixing the first filtrate and the second filtrate, and melting the antler glue into the mixed solution to obtain a decoction of the medicine.
2. The traditional Chinese medicine composition for treating avascular necrosis of the femoral head as claimed in claim 1, which is prepared from the following raw materials in parts by weight:
6g of deerhorn glue, 30g of astragalus membranaceus, 20g of codonopsis pilosula, 2 centipedes, 10g of ground beetles, 5g of monkshood, 10g of cassia twig, 10g of semen brassicae, 5g of ephedra, 10g of ligusticum wallichii, 20g of prepared rehmannia root, 10g of herba epimedii, 20g of rhizoma polygonati, 6g of angelica sinensis, 10g of vinegar-processed curcuma zedoary, 10g of prepared fructus aurantii, 5g of liquorice, 10g of radix bupleuri, 10g of radix curcumae, 5g of safflower carthamus, 15g of radix step.
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|---|---|---|---|---|
| CN1319414A (en) * | 2001-01-19 | 2001-10-31 | 刘军 | Medicine for treating hecrosis of femoral head |
| CN101428096A (en) * | 2007-11-06 | 2009-05-13 | 魏敬成 | Chinese medicinal composition for treating femoral head necrosis and preparation method thereof |
| CN106266312A (en) * | 2016-09-20 | 2017-01-04 | 四川兴聚焦医药科技有限责任公司 | A kind of Chinese medicine for oral administration ball treating femur head necrosis and preparation method thereof |
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2017
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| CN1319414A (en) * | 2001-01-19 | 2001-10-31 | 刘军 | Medicine for treating hecrosis of femoral head |
| CN101428096A (en) * | 2007-11-06 | 2009-05-13 | 魏敬成 | Chinese medicinal composition for treating femoral head necrosis and preparation method thereof |
| CN106266312A (en) * | 2016-09-20 | 2017-01-04 | 四川兴聚焦医药科技有限责任公司 | A kind of Chinese medicine for oral administration ball treating femur head necrosis and preparation method thereof |
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