CN103655873B - A kind of external-applied ointment for the treatment of tinea unguium - Google Patents
A kind of external-applied ointment for the treatment of tinea unguium Download PDFInfo
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- CN103655873B CN103655873B CN201310726954.6A CN201310726954A CN103655873B CN 103655873 B CN103655873 B CN 103655873B CN 201310726954 A CN201310726954 A CN 201310726954A CN 103655873 B CN103655873 B CN 103655873B
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Abstract
The present invention relates to a kind of external-applied ointment for the treatment of tinea unguium, be made up of the crude drug of following weight portion: Radix Sophorae Flavescentis powder 100 ~ 120 parts, Cortex Dictamni powder 60 ~ 80 parts, 60 ~ 80 parts, Radix Rumicis Crispi powder, Radix Notoginseng powder 70 ~ 90 parts, extract of willow bark 80 ~ 100 parts, 100 ~ 120 parts, benzoic acid, boric acid 110 ~ 130 parts, 60 ~ 80 parts, glacial acetic acid, Fructus Foeniculi Pericarpium Zanthoxyli extracting solution 270 ~ 300 parts.Advantage is: ointment have employed Integrated TCM, the strong permeability of Western medicine, bactericidal feature are given full play to, simultaneously, pruritus pain, skin allergy that the strong and stimulating improving Western medicine with Chinese medicine causes, play anti-inflammatory analgetic, improve heat clearing and damp drying, reach and adjust smooth QI and blood, Yin Yang balancing, the effect of dredging liver.Administration time is short, and without pain, have no side effect, curative effect is high, and cost is low, easy to use, and therapeutic effect is remarkable.
Description
Technical field
The present invention relates to a kind of external-applied ointment for the treatment of tinea unguium.
Background technology
Tinea unguium (tinea unguium) is the pathological changes that dermatophytosis invades caused by deck, is the mycosis under one betides finger (toe) first and first.It is that fungal infection causes nail structure to change, color change, and a kind of dermatosis mutually infected, the main manifestations of tinea unguium is: fingernail is out of shape, and thickens, easily comes off, and is separated.Have now found that tinea unguium has more than 25 kinds different fungal infection to form.Tinea unguium is the disease that a kind of very refractory is healed.At present, the medicine for external use of Western medicine, treatment by Chinese herbs tinea unguium has a lot, but it is strong that some Western medicine also exist zest, easily causes insufferable pain, easily make skin allergy, the shortcoming that side effect is large; Some Chinese medicine also exists the defect that permeability is inadequate, administration time is long.Some medicine for external use are cured the symptoms, not the disease, volatile, and drug effect is unbalanced, persist to affected part causes curative effect obviously to decline, have in some medicine short time to use and have certain effect, the long-time curative effect that uses is not obvious, easily recurs, the medicine for external use price also had is high, adds the treatment cost of patient.
Summary of the invention
For overcoming the deficiencies in the prior art, the object of this invention is to provide a kind of external-applied ointment for the treatment of tinea unguium, reduce in therapeutic process stimulate and pain, permeability by force, anti-inflammation, treatment time is short, good effect, cost are low, thoroughly kill disease first fungus, without recurrence after curing.
For achieving the above object, the present invention is achieved through the following technical solutions:
Treat an external-applied ointment for tinea unguium, be made up of the crude drug of following weight portion: Radix Sophorae Flavescentis powder 100 ~ 120 parts, Cortex Dictamni powder 60 ~ 80 parts, 60 ~ 80 parts, Radix Rumicis Crispi powder, Radix Notoginseng powder 70 ~ 90 parts, extract of willow bark 80 ~ 100 parts, 100 ~ 120 parts, benzoic acid, boric acid 110 ~ 130 parts, 60 ~ 80 parts, glacial acetic acid, Fructus Foeniculi Pericarpium Zanthoxyli extracting solution 270 ~ 300 parts.
Described Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is made up of distilled water 100 parts, 1 ~ 3 part, Fructus Foeniculi, 3 ~ 6 parts, Pericarpium Zanthoxyli, the compound method of Fructus Foeniculi Pericarpium Zanthoxyli extracting solution: Fructus Foeniculi, Pericarpium Zanthoxyli are pulverized respectively and sieves with upper screen cloth with 80 orders, get distilled water, add the Fructus Foeniculi powder after sieving, Zanthoxyli Bungeani powder, Hybrid Heating boils 40 minutes, is cooled to room temperature, soaks 24 hours, filter with 300 eye mesh screens, make Fructus Foeniculi Pericarpium Zanthoxyli extracting solution.
Described Radix Sophorae Flavescentis powder, Cortex Dictamni powder, Radix Rumicis Crispi powder, Radix Notoginseng powder are the powder of more than 300 orders.
Compared with prior art, the invention has the beneficial effects as follows:
Ointment have employed Integrated TCM, has given full play to the strong permeability of Western medicine, bactericidal feature, simultaneously, pruritus pain, skin allergy that the strong and stimulating improving Western medicine with Chinese medicine causes, play anti-inflammatory analgetic, improves heat clearing and damp drying, reach and adjust smooth QI and blood, Yin Yang balancing, the effect of dredging liver.Therefore, administration time is short, and without pain, have no side effect, curative effect is high, and cost is low, easy to use, and therapeutic effect is remarkable, thus reaches the object for the treatment of both the principal and secondary aspects of a disease.
Detailed description of the invention
Below the present invention is described in detail, but it should be noted that enforcement of the present invention is not limited to following embodiment.
The external-applied ointment for the treatment of tinea unguium, be mixed by the crude drug of following weight portion: Radix Sophorae Flavescentis powder 100 ~ 120 parts, Cortex Dictamni powder 60 ~ 80 parts, 60 ~ 80 parts, Radix Rumicis Crispi powder, Radix Notoginseng powder 70 ~ 90 parts, extract of willow bark 80 ~ 100 parts, 100 ~ 120 parts, benzoic acid, boric acid 110 ~ 130 parts, 60 ~ 80 parts, glacial acetic acid, Fructus Foeniculi Pericarpium Zanthoxyli extracting solution 270 ~ 300 parts, the compound method of described Fructus Foeniculi Pericarpium Zanthoxyli extracting solution: by Fructus Foeniculi, Pericarpium Zanthoxyli pulverizes and sieves more than 80 orders respectively, get distilled water 100 parts, add Fructus Foeniculi powder 1 ~ 3 part, Zanthoxyli Bungeani powder 3 ~ 6 parts, Hybrid Heating boils 40 minutes, be cooled to room temperature, soak 24 hours, filter with 300 eye mesh screens, make Fructus Foeniculi Pericarpium Zanthoxyli extracting solution.Described Radix Sophorae Flavescentis powder, Cortex Dictamni powder, Radix Rumicis Crispi powder, Radix Notoginseng powder are the powder of more than 300 orders.Radix Sophorae Flavescentis powder, Cortex Dictamni powder, Radix Rumicis Crispi powder, Radix Notoginseng powder, extract of willow bark, benzoic acid boric acid, glacial acetic acid, Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, glycerol 30 parts, 60 parts, vaseline are made this ointment according to said ratio mixed grinding.
Carry out the preparation method setting forth medicine of the present invention further by the following examples:
Embodiment 1:
Radix Sophorae Flavescentis powder 105 parts, Cortex Dictamni powder 62 parts, 62 parts, Radix Rumicis Crispi powder, Radix Notoginseng powder 70 parts, extract of willow bark 81 parts, 102 parts, benzoic acid, boric acid 112 parts, 62 parts, glacial acetic acid, Fructus Foeniculi Pericarpium Zanthoxyli extracting solution 275 parts, glycerol 30 parts, 60 parts, vaseline, the compound method of described Fructus Foeniculi Pericarpium Zanthoxyli extracting solution: Fructus Foeniculi, Pericarpium Zanthoxyli were pulverized 80 mesh sieves respectively, get distilled water 100 parts, add Fructus Foeniculi powder 1 part, Zanthoxyli Bungeani powder 4 parts, Hybrid Heating boils 40 minutes, be cooled to room temperature, soak 24 hours, filter with 300 eye mesh screens, make Fructus Foeniculi Pericarpium Zanthoxyli extracting solution.Described Radix Sophorae Flavescentis powder, Cortex Dictamni powder, Radix Rumicis Crispi powder, Radix Notoginseng powder are 300 order powder.Radix Sophorae Flavescentis powder, Cortex Dictamni powder, Radix Rumicis Crispi powder, Radix Notoginseng powder, extract of willow bark, benzoic acid boric acid, glacial acetic acid, Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, glycerol and vaseline are made this ointment according to said ratio mixed grinding.
Embodiment 2:
Radix Sophorae Flavescentis powder 118 parts, Cortex Dictamni powder 78 parts, 78 parts, Radix Rumicis Crispi powder, Radix Notoginseng powder 89 parts, extract of willow bark 100 parts, 118 parts, benzoic acid, boric acid 128 parts, 80 parts, glacial acetic acid, Fructus Foeniculi Pericarpium Zanthoxyli extracting solution 290 parts, glycerol 30 parts, 60 parts, vaseline, the compound method of described Fructus Foeniculi Pericarpium Zanthoxyli extracting solution: Fructus Foeniculi, Pericarpium Zanthoxyli are pulverized and sieved respectively 100 orders, get distilled water 100 parts, add Fructus Foeniculi powder 2.5 parts, Zanthoxyli Bungeani powder 5 parts, Hybrid Heating boils 40 minutes, be cooled to room temperature, soak 24 hours, filter with 300 eye mesh screens, make Fructus Foeniculi Pericarpium Zanthoxyli extracting solution.Described Radix Sophorae Flavescentis powder, Cortex Dictamni powder, Radix Rumicis Crispi powder, Radix Notoginseng powder are 300 order powder.Radix Sophorae Flavescentis powder, Cortex Dictamni powder, Radix Rumicis Crispi powder, Radix Notoginseng powder, extract of willow bark, benzoic acid boric acid, glacial acetic acid, Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, glycerol and vaseline are made this ointment according to said ratio mixed grinding.
Embodiment 3:
Radix Sophorae Flavescentis powder 110 parts, Cortex Dictamni powder 70 parts, 75 parts, Radix Rumicis Crispi powder, Radix Notoginseng powder 85 parts, extract of willow bark 95 parts, 110 parts, benzoic acid, boric acid 120 parts, 70 parts, glacial acetic acid, Fructus Foeniculi Pericarpium Zanthoxyli extracting solution 280 parts, glycerol 30 parts, 60 parts, vaseline, the compound method of described Fructus Foeniculi Pericarpium Zanthoxyli extracting solution: Fructus Foeniculi, Pericarpium Zanthoxyli were pulverized 100 mesh sieves respectively, get distilled water 100 parts, add Fructus Foeniculi powder 2 parts, Zanthoxyli Bungeani powder 4 parts, Hybrid Heating boils 40 minutes, be cooled to room temperature, soak 24 hours, filter with 300 eye mesh screens, make Fructus Foeniculi Pericarpium Zanthoxyli extracting solution.Described Radix Sophorae Flavescentis powder, Cortex Dictamni powder, Radix Rumicis Crispi powder, Radix Notoginseng powder are 300 order powder.Radix Sophorae Flavescentis powder, Cortex Dictamni powder, Radix Rumicis Crispi powder, Radix Notoginseng powder, extract of willow bark, benzoic acid boric acid, glacial acetic acid, Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, glycerol and vaseline are made this ointment according to said ratio mixed grinding.
Medicament selection Radix Sophorae Flavescentis of the present invention, Cortex Dictamni, Radix Rumicis Crispi, Radix Notoginseng, extract of willow bark, benzoic acid, boric acid, glacial acetic acid, Fructus Foeniculi Pericarpium Zanthoxyli extracting solution, glycerol, vaseline carry out combining, effect of each medicine is made by these drug regimens to produce synergism, thus effectively can treat tinea unguium, the property of medicine, the action and efficacy of wherein medication are:
Fructus Foeniculi: pungent, temperature; Effect warming YANG to expel cold, regulating QI to relieve pain; Control dry, beriberi caused by pathogenic damp.
Pericarpium Zanthoxyli: nature and flavor are pungent, warm, its effect warming spleen and stomach for dispelling cold, dehumidifying, warming middle-JIAO to relieve pain, killing parasites for relieving itching; Be adapted to eczema pruritus, stubborn dermatitis brothers rhagades of the skin etc.
Radix Sophorae Flavescentis: heat clearing and damp drying, parasite killing, diuresis, for eczema, eczema, skin pruritus, scabies leprosy.
Cortex Dictamni: can dispel the wind, dampness, heat clearing away, removing toxic substances; Cortex Dictamni controls wind heat sore, scabies, itchy skin eruption.
Radix Rumicis Crispi: bitter, micro-puckery, cold; Effect cooling blood for hemostasis, parasite killing controls tinea.
Radix Notoginseng: sweet in the mouth, micro-hardship, warm in nature, hemostasis, dissipating blood stasis, reducing swelling and alleviating pain; Heat-clearing and toxic substances removing.
Bark of willow: cold in nature, bitter in the mouth; To eliminate the phlegm improving eyesight, heat-clearing and toxic substances removing, diuresis Radix Saposhnikoviae, eliminating inflammation and expelling toxin, treatment scabies persistent ailment; Its extract has removal cutin, enhancing Skin Cell vigor, anti-inflammation, raising skin immunity, resists the erosion of extraneous antibacterial, repairs impaired skin effect; The extract of willow bark adopted in this medicament commercially can buy, as: the extract of willow bark that Xi'an Hong Yue biological engineering company limited produces, containing the white powder of salicoside more than 90%.
Benzoic acid: disinfection preservative, can grow, outward for the mycotic infection of superficial part such as tinea corporis, tinea manus and pedis by Antifungi.
Boric acid: effect is external antibacterial, disinfectant, astringent and antiseptic.All inhibitory action is had to various bacteria, mycete; As the cleaning agent of skin lesion, also can be used for acute eczema, impetigo etc.
Glacial acetic acid: antibacterial, destroys fungus living environment, and plays bactericidal action; Be used for the treatment of the treatment of the infection of various superficial skin fungus and clavus wart.
The using method of this ointment:
1, first dry clean for sick first;
2, by ointment uniform application in whole sick first first face, thickness is about 1mm;
3, with adhesive bandage wrapping, take off after 8 hours, once a day.
Adopt the external-applied ointment of this medicinal ointment therapy tinea unguium, as stated above 200 onychomycosis are treated and its curative effect situation of tracing observation as follows:
Curative effect judging standard:
Effective: slight expansion sense appears in medication future trouble first, after a few days, (20 days) trouble first nail root grows new first, turns white, smooth;
Recovery from illness: after the medication a few days (90 days), new first slowly grows, and sick first is ejected by new first gradually and comes off, and new first is turned white interior red, smooth, and new first is smooth shinny, grows normal nail.Classification curative effect:
Patients with mild: 90 people, sick time, within 3 years, suffers from first number 1 ~ 3.Medication 4 ~ 6 days, stops using, and 20 days future trouble first nail roots turn white, smooth; Fingernail is after 90 days, and toenail is after 360 days, and new first slowly grows, sick onychoptosis, grows smooth shinny new first.1 people is had not reach remarkable and criterion of cure.Obvious effective rate, cure rate 99%.
Moderate patient: 58 people, sick time, within 5 ~ 7 years, suffers from first number 1 ~ 10.Medication 5 ~ 8 days, presents marked feature, discontinues medication, and fingernail is after 90 days, and toenail grows complete new first after 360 days, has 2 people not reach remarkable and criterion of cure.Obvious effective rate, cure rate 95.4%.
Severe patient: 52 people, sick time more than 10 years, suffers from first number 5 ~ 12.Medication 6 ~ 8 days, presents marked feature, discontinues medication, and fingernail is after 90 days, and toenail grows complete new first after 360 days, has 3 people not reach remarkable and criterion of cure.Obvious effective rate, cure rate 94.3%.
Above-mentioned 200 the average obvious effective rates of case, cure rates 96%, average effectiveness level 98%, cure rate 96%, without any side effects, observed after 1 year and there is no recurrent cases.
Model case:
1, Seedling, man, 65 years old, Liaoning people from Donggang City, foot suffered from tinea unguium 12 years, and toenail is greyish black thickening, and every day in whole sick first first face with product uniform application of the present invention, wraps up and takes off after 8 hours, and wrapping was discontinued medication after 7 days continuously.After 30 days, suffer from nail root portion and slowly occur normal toenail, after 160 days, sick first is ejected by new first gradually and comes off, and normal toenail all grows.
2, king so-and-so, female, 60 years old, people from Zhenxing District, Dandong City, foot suffers from tinea unguium 10 years, and toenail is greyish black, and recovery from illness is failed in many places treatment; Every day with ointment uniform application of the present invention, wraps up and takes off after 8 hours on sick first first face.Continuous wrapping was discontinued medication after 7 days.After 35 days, suffer from nail root portion and slowly occur normal toenail, after 165 days, sick first is ejected by new first gradually and comes off, and normal toenail all grows.
Ointment have employed Integrated TCM, has given full play to the strong permeability of Western medicine, bactericidal feature, simultaneously, pruritus pain, skin allergy that the strong and stimulating improving Western medicine with Chinese medicine causes, play anti-inflammatory analgetic, improves heat clearing and damp drying, reach and adjust smooth QI and blood, Yin Yang balancing, the effect of dredging liver.Therefore, administration time is short, and without pain, have no side effect, curative effect is high, and cost is low, easy to use, and therapeutic effect is remarkable, thus reaches the object for the treatment of both the principal and secondary aspects of a disease.In ointment, the subtle powder smash of part Chinese medicine reaches more than 300 orders, and cell can be made directly to absorb and be effective.
Chinese medicine proportioning extracting method of the present invention and Chinese medicine Western medicine matching method and method of quality control, effectively can control drug quality and quantity thus guarantee clinical efficacy and drug safety.
Sick first wrapping method provided by the present invention, simple, convenient, oneself can operate after patient buys, overcome treatment tinea unguium at present and must arrive appointed place, first soften, then cut first, oneself inoperable problem of rear medicine-feeding patient.
Claims (1)
1. treat the external-applied ointment of tinea unguium for one kind, it is characterized in that, be made up of the crude drug of following weight portion: Radix Sophorae Flavescentis powder 100 ~ 120 parts, Cortex Dictamni powder 60 ~ 80 parts, 60 ~ 80 parts, Radix Rumicis Crispi powder, Radix Notoginseng powder 70 ~ 90 parts, extract of willow bark 80 ~ 100 parts, 100 ~ 120 parts, benzoic acid, boric acid 110 ~ 130 parts, 60 ~ 80 parts, glacial acetic acid, Fructus Foeniculi Pericarpium Zanthoxyli extracting solution 270 ~ 300 parts; Described Fructus Foeniculi Pericarpium Zanthoxyli extracting solution is made up of distilled water 100 parts, 1 ~ 3 part, Fructus Foeniculi, 3 ~ 6 parts, Pericarpium Zanthoxyli, the compound method of Fructus Foeniculi Pericarpium Zanthoxyli extracting solution: Fructus Foeniculi, Pericarpium Zanthoxyli are pulverized respectively and sieves with upper screen cloth with 80 orders, get distilled water, add the Fructus Foeniculi powder after sieving, Zanthoxyli Bungeani powder, Hybrid Heating boils 40 minutes, is cooled to room temperature, soaks 24 hours, filter with 300 eye mesh screens, make Fructus Foeniculi Pericarpium Zanthoxyli extracting solution; Described Radix Sophorae Flavescentis powder, Cortex Dictamni powder, Radix Rumicis Crispi powder, Radix Notoginseng powder are the powder of more than 300 orders.
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| CN103908529A (en) * | 2014-04-04 | 2014-07-09 | 青岛市城阳区人民医院 | Traditional Chinese medicine ointment for treating roseola infantum |
| CN106822648A (en) * | 2017-03-14 | 2017-06-13 | 四川香龙丹医药科技有限公司 | A kind of medicine of fast treating onychomycosis |
| CN107362176B (en) * | 2017-07-04 | 2020-02-18 | 贵州神奇药物研究院 | Composition for treating onychomycosis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1174073A (en) * | 1997-07-12 | 1998-02-25 | 迟经惠 | Medicine for treating uneven nail |
| KR20020095330A (en) * | 2001-06-14 | 2002-12-26 | 신래관 | Rumex crispus linne contained inhibition activity against mycosis |
| CN1390591A (en) * | 2002-07-18 | 2003-01-15 | 代元丁 | Chinese-medicinal liniment fr treating dermatopathy |
| CN101049362A (en) * | 2007-05-09 | 2007-10-10 | 丹东源甲科技有限公司 | External remedy for treating onychomycosis |
| CN102764331A (en) * | 2012-07-30 | 2012-11-07 | 陈丽杰 | External medicine for treating nail ringworm and whitlow |
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2013
- 2013-12-25 CN CN201310726954.6A patent/CN103655873B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1174073A (en) * | 1997-07-12 | 1998-02-25 | 迟经惠 | Medicine for treating uneven nail |
| KR20020095330A (en) * | 2001-06-14 | 2002-12-26 | 신래관 | Rumex crispus linne contained inhibition activity against mycosis |
| CN1390591A (en) * | 2002-07-18 | 2003-01-15 | 代元丁 | Chinese-medicinal liniment fr treating dermatopathy |
| CN101049362A (en) * | 2007-05-09 | 2007-10-10 | 丹东源甲科技有限公司 | External remedy for treating onychomycosis |
| CN102764331A (en) * | 2012-07-30 | 2012-11-07 | 陈丽杰 | External medicine for treating nail ringworm and whitlow |
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