CN104189184A - Traditional Chinese medicine thermosensible gel for treating hemorrhoids - Google Patents
Traditional Chinese medicine thermosensible gel for treating hemorrhoids Download PDFInfo
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine thermosensible gel for treating hemorrhoids. The preparation method comprises the following steps: weighing the raw materials in percentage by weight: 10-40 percent of panax notoginseng, 5-20 percent of cortex moutan, 5-20 percent of phellodendron, 5-20 percent of sophora flavescens ait, 5-15 percent of sophoricoside, 5-15 percent of galla chinensis and 5-15 percent of borneol; crushing the panax notoginseng, the cortex moutan, the phellodendron, the sophora flavescens ait and the sophoricoside into coarse powder, putting the coarse powder in a percolating extraction pot, adding 70 percent ethyl alcohol, soaking, percolating, and carrying out vacuum concentration to obtain a liquid extract 1; putting the galla chinensis in a multifunctional extraction pot, adding water, decocting twice, combining filtrates, and carrying out vacuum concentration to obtain a liquid extract 2; combining the liquid extract 1 and the liquid extract 2, and spray drying to obtain an extract powder; putting the borneol in a crusher, and crushing into fine powder; mixing the extract powder and the borneol fine powder according to an equivalent increasing method; and according to the weight ratio, adding 30-50 parts of poloxamer 407, 1-5 parts of poloxamer 188, 0.4-1 part of benzalkonium bromide and 180 parts of purified water after the per 100 parts of medicinal materials are extracted, so as to prepare the thermosensible gel. According to the preparation method, as water and the ethyl alcohol are used as extraction solvents only in the whole technological process, no wastewater and waste gas are generated in the production process, and the traditional Chinese medicine thermosensible gel is suitable for industrial production.
Description
Technical field
The present invention relates to Chinese medicine for external application field, especially, relate to a kind of temperature sensitive gel of Chinese medicine for the treatment of hemorrhoid.
Background technology
Hemorrhoid are a kind of common, multiple anus, traditional view generally hemorrhoid are defined as under rectum end mucosa and anal canal skin under hemorrhoidal veins from the soft vein group expanding, varicose forms.Its topmost feature be have blood in stool, deviate from, hurt like hell, easily outbreak repeatedly so that have a strong impact on the normal work of people and life.The sickness rate of hemorrhoid is very high, and the ratio that accounts for according to statistics crowd 60% all suffers from hemorrhoid in various degree, and just there be saying of " ten people's nine hemorrhoid " in China from ancient times.The age of onset of hemorrhoid all can be occurred to old any age by child, but 20-40 year is many.Most patients increase the weight of gradually with age growth, the old minimizing physical exertion of some patients, and symptom alleviates, and blood stasis dwindles.But have quite a few patient, itself is without any symptom, and proctoscopy also finds that there is internal hemorrhoid, also should not ignore.
In modern medicine, the treatment emphasis of hemorrhoid is to eliminate and relief of symptoms, and non-operative treatment is top-priority therapy, and for blood stasis itself and remove some operative therapys of the cause of disease, only in the situation that non-operative treatment is invalid, just consideration is applied.Hemorrhoid patients, due under the long-term torment in having an intense pain, generally has the feared state of mind for the Therapeutic Method of operation, so the expectant treatment first-selection of vast hemorrhoid patients often.
Anus medicine for external use, can make medicine directly act on wound surface, and the efficacy of a drug sick institute that goes directly makes it to absorb and plays the effect of control, can avoid medicine too many levels circulation deactivation in vivo, reduces drug effect, avoids some side effect of medicine simultaneously.Chinese medicine external treatment hemorrhoid have long history.
The Chinese medicine compound that the temperature sensitive gel of Chinese medicine of the present invention is made up of Radix Notoginseng, Cortex Moutan, Cortex Phellodendri, Radix Sophorae Flavescentis, the Fructus Sophorae, Galla Chinensis, Borneolum Syntheticum etc., extract the gel that adds adjuvant to make after refining to have temperature sensitive feature, when this gel room temperature preservation, be liquid, be applied to skin mucosa surface after coagulation gel, be used for the treatment of hemorrhoid, this dosage form is easy to use, and effect is lasting, is difficult for pollution clothes.This compound recipe is by following ingredients:
Radix Notoginseng: this product is panax araliaceae plant
panax notoginseng (Burk.) F.H.
chendry root and rhizome.Sweet in the mouth, micro-hardship, warm in nature, there is removing stasis to stop bleeding, the effects such as analgesic therapy of invigorating blood circulation.For controlling the good merchantable brand of all cards of blood stasis, it is traumatology key medicine.Radix Notoginseng mainly, containing Ginsenosides, arasaponin class, Radix Notoginseng propylhomoserin class and Radix Notoginseng polysaccharide class etc., is its main active substance.Radix Notoginseng propylhomoserin has obvious anastalsis, and can obviously increase platelet counts and shorten clotting time; Ginsenoside, arasaponin energy anticoagulant and inhibition thrombosis; Radix Notoginseng total glycosides can regulate immunity, has significant antiinflammatory action, and has significant maincenter analgesic effect, and saponin Rb group has stronger analgesic effect.
Cortex Moutan: this product is ranunculaceae peony
paeonia suffruticasa Andr.dry root bark.Bitter in the mouth, pungent, cold nature, has clearing away heat and cooling blood, the effects such as blood circulation promoting and blood stasis dispelling.Cortex Moutan has antibacterial anti-inflammatory effect.In performance antiinflammatory action, can not suppress normal body fluid immunologic function.Its active ingredient is that gallic acid has remarkable antibacterial action to dysentery bacterium, bacillus pyocyaneus and staphylococcus aureus, and Cortex Moutan can be able to suppress platelet arachidonic acid and produce thromboxane A2, and then anticoagulant.
Cortex Phellodendri: this product is rutaceae wampee
phellodendron chinense Schneid.dry bark.Bitter in the mouth, cold in nature, energy heat clearing and damp drying, except part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels damp-edema." medication heart method " records Cortex Phellodendri: " control the unbearably painful person of skin ulcer." Cortex Phellodendri contains large number of biological alkali components, has the antibacterial action of wide spectrum, can block nerves joint, nervus centralis is had to the effect of inhibition.
Radix Sophorae Flavescentis: this product is leguminous plant Radix Sophorae Flavescentis
sophora flavescens Ait.dry root.Radix Sophorae Flavescentis heat clearing and damp drying, extensive use and multiple humidifier fever, external can be decocted soup washout, for hemorrhoid.Radix Sophorae Flavescentis has the effect of anti-inflammation, and Propiobacterium, staphylococcus aureus, escherichia coli are all had to inhibitory action,
The Fructus Sophorae: this product is leguminous plant Chinese scholartree
sophora japonica L.dry mature fruit.Fructus Sophorae clearing away heat-fire, cooling blood for hemostasis.Have blood in stool for intestinal heat, hemorrhoid are swollen hemorrhage.
Galla Chinensis: this product is Anacardiaceae plant Fructus rhois chinensis
rhus chinensis Mill., blue or green bran poplar
rhus potaninii Maxim.and Radix Rhois Sinicae
rhus punjabensis Stew. var.sinica (Diels) Rehd. et Wils.insect gall on leaf, is mainly melaphis chinensis Baker
melaphis chinensis (Bell) Bakerparasitic and form.External energy removing dampness sore, and have the merit of removing toxic substances and promoting subsidence of swelling." Kaibao Bencao " records Galla Chinensis: " treat tooth a surname skin ulcer and turn over, lungs pathogenic wind toxic slime flux skin style eczema, the cancer pus of itching, five hemorrhoid hematochezia are more than, children's's face nasal abscess skin ulcer." Galla Chinensis contains a large amount of tannic acids.After the ulcer contact tannic acid of skin and thin film, its histone is solidified, and forms one deck tunicle, thereby plays the effect of convergence, meanwhile, little vasoconstriction, blood coagulation, and play anastalsis.Galla Chinensis also has antibacterial and bactericidal action to various pathogens.
Borneolum Syntheticum: this product is rosaceous plant Folium Eriobotryae
eriobotrya japonica (Thunb.) Lindl.dried leaves.There is logical all keys, loose stagnated fire, clearing away heat to alleviate pain, swell and ache for skin infection, the diseases such as the sore being festered and unhealed." Haiyao Bencao, Oversea Materia Medica " records Borneolum Syntheticum, and " external oculopathy eye in main, three worms, control five hemorrhoid, improving eyesight, relieving palpitation, secret essence." Borneolum Syntheticum (Borneolum Syntheticum) can promote that effective ingredient absorbs through skin.Resinous and the volatile oil of Borneolum Syntheticum, synthetic borneol, containing racemization mixing Borneolum Syntheticum, all has obvious pain relieving sedation; Low concentration has bacteriostasis, and high concentration can sterilizing: also have the effects such as antiinflammatory, antibacterial and spasmolytic simultaneously.
At present, there is not yet taking Radix Notoginseng, Cortex Moutan, Cortex Phellodendri, Radix Sophorae Flavescentis, the Fructus Sophorae, Galla Chinensis, Borneolum Syntheticum as main point the report taking Pu Luoshamu 407, LUTROL micro 68 MP, benzalkonium bromide, purified water as the Chinese medicine for external application of adjuvant.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, a kind of compositing formula of the temperature sensitive gel of Chinese medicine for the treatment of hemorrhoid is provided and is prepared into the method for thermosensitive hydrogel agent.The temperature sensitive gel of Chinese medicine of the present invention have invigorate blood circulation, the effect such as antiinflammatory, pain relieving, hemostasis, detumescence, can take effect rapidly for various anorectal diseases such as internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, pruritus ani, anal fissure, proctoptosis, hemorrhoid operation sequela, effective percentage reaches more than 90%, there is short treating period, easy to use, good effect, is difficult for recurrence, and the feature such as have no side effect.
The object of the invention is to be achieved through the following technical solutions:
A preparation method for the treatment of the temperature sensitive gel of Chinese medicine of hemorrhoid, is characterized in that, preparation process is as follows:
(1), according to the percentage by weight of Radix Notoginseng, Cortex Moutan, Cortex Phellodendri, Radix Sophorae Flavescentis, the Fructus Sophorae, Galla Chinensis, Borneolum Syntheticum: 10-40%, 5-20%, 5-20%, 5-20%, 5-15%, 5-15%, 5-25%, draw materials;
(2), Radix Notoginseng, Cortex Moutan, Cortex Phellodendri, Radix Sophorae Flavescentis, the Fructus Sophorae are ground into coarse powder, put in percolation filtration extraction pot, add 70% soak with ethanol of 1 times of amount left and right about 24 hours, 70% ethanol percolation that adds 7 times of amounts left and right obtains percolate, decompression recycling ethanol, the concentrated extractum 1 that to obtain;
(3), Galla Chinensis is put in multi-function extractor, the decocting that adds 8 times of amounts left and right boils 2 times, merging filtrate, and concentrating under reduced pressure obtains extractum 2;
(4), merge extractum 1 and extractum 2, mix homogeneously, the dry extract powder that to obtain of spraying;
(5), Borneolum Syntheticum is put in pulverizer, be ground into fine powder;
(6), extract powder and Borneolum Syntheticum fine powder are mixed to get to the principal agent powder of this thermosensitive hydrogel by equivalent incremental method;
(7), Pu Luoshamu 407, LUTROL micro 68 MP are added in pure water, be uniformly mixed to complete swelling, add benzalkonium bromide to be uniformly mixed, obtain thermosensitive hydrogel substrate;
(8), principal agent powder is added in thermosensitive hydrogel substrate, be uniformly mixed the rear colloid mill mix homogeneously of crossing;
(9), specification in accordance with regulations bottle, label, outer package.
The preparation method of the temperature sensitive gel of Chinese medicine of described treatment hemorrhoid, is characterized in that,
Every 100 parts of medical materials are got Pu Luoshamu 407 30-40 parts, LUTROL micro 68 MP 1-5 part, benzalkonium bromide 0.4-1 part, 160 parts of mix homogeneously of purified water.
This compound recipe has effect of alleviating pain and detumescence, expelling pus and promoting granulation.Monarch drug in pseudo-ginseng blood-circulation-invigovating blood stasis dispelling in side, the reducing swelling and alleviating pain side of being; Cortex Moutan clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, the effect as ministerial drug principal drug assistance with the pain relieving of reinforcement promoting blood circulation and detumescence; Cortex Phellodendri, Radix Sophorae Flavescentis heat clearing and damp drying, except part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels damp-edema, there is obvious analgesia, improve blood circulation and antiphlogistic antibacterial effect, Fructus Sophorae cooling blood for hemostasis, Galla Chinensis astringent therapy detumescence sore, can form protecting film with promoting healing on wound surface, and principal drug assistance is to strengthen alleviating pain and detumescence, wound healing is supplementary drug altogether; Borneolum Syntheticum clearing away heat to alleviate pain, and can promote that effective ingredient absorbs through skin, for assistant makes it medicine.All medicines are harmonious, the merit of playing altogether alleviating pain and detumescence, holding back creation flesh.
This Chinese medicine compound is extracted the refining rear adjuvant that coordinates and is made thermosensitive hydrogel, and under low temperature, this gel is liquid, is conveniently applied in affected part; When close with body temperature, be transformed into solid-state or semi-solid gel, can keep dauer effect, and be difficult for pollution clothes.
Detailed description of the invention
Embodiment 1
Get respectively Radix Notoginseng 400g, Cortex Moutan 100g, Cortex Phellodendri 100g, Radix Sophorae Flavescentis 100g, Fructus Sophorae 100g, Galla Chinensis 50g, Borneolum Syntheticum 150g, Radix Notoginseng, Cortex Moutan, Cortex Phellodendri, Radix Sophorae Flavescentis, the Fructus Sophorae are ground into coarse powder, put in percolation filtration extraction pot, add 1 times of amount 70% soak with ethanol 24 hours, add 7 times of amount 70% ethanol percolations and obtain percolate, decompression recycling ethanol, concentrates to obtain extractum 1; Galla Chinensis is put in multi-function extractor, added 8 times of water gagings and decoct 2 times, merging filtrate, concentrating under reduced pressure obtains extractum 2; Merge extractum 1 and extractum 2, mix homogeneously, spraying is dried to obtain extract powder; Borneolum Syntheticum is put in pulverizer, be ground into fine powder; Extract powder and Borneolum Syntheticum fine powder are mixed to get to principal agent powder by equivalent incremental method.Get Pu Luoshamu 407 400g, LUTROL micro 68 MP 50g, benzalkonium bromide 4g, purified water 1600g.Pu Luoshamu 407, LUTROL micro 68 MP are added in pure water, be uniformly mixed to complete swelling, add benzalkonium bromide to be uniformly mixed, obtain thermosensitive hydrogel substrate.Principal agent powder is added to thermosensitive hydrogel substrate, be uniformly mixed the rear colloid mill mix homogeneously of crossing.Pack 50ml plastic bottle into, label, outer package.
The present embodiment is treated clinical 200 routine patients, wherein male 129 examples, female's 71 examples, wherein internal hemorrhoid 55 examples, external hemorrhoid 50 examples, mixed hemorrhoid 50 examples, anal fistula 25 examples, anal fissure 20 examples.Treat after 30 days, internal hemorrhoid is cured 55 examples; External hemorrhoid is cured 45 examples, and symptom obviously alleviates 5 examples; Mixed hemorrhoid is cured 42 examples, and symptom obviously alleviates 8 examples; Anal fistula symptom obviously alleviates 8 examples, and symptom alleviates 15 examples; Anal fissure symptom obviously alleviates 5 examples, and symptom alleviates 13 examples.Total effective rate reaches more than 90%.
Embodiment 2
Get respectively Radix Notoginseng 200g, Cortex Moutan 150g, Cortex Phellodendri 150g, Radix Sophorae Flavescentis 150g, Fructus Sophorae 150g, Galla Chinensis 100g, Borneolum Syntheticum 100g, Radix Notoginseng, Cortex Moutan, Cortex Phellodendri, Radix Sophorae Flavescentis, the Fructus Sophorae are ground into coarse powder, put in percolation filtration extraction pot, add 1 times of amount 70% soak with ethanol 24 hours, add 7 times of amount 70% ethanol percolations and obtain percolate, decompression recycling ethanol, concentrates to obtain extractum 1; Galla Chinensis is put in multi-function extractor, added 8 times of water gagings and decoct 2 times, merging filtrate, concentrating under reduced pressure obtains extractum 2; Merge extractum 1 and extractum 2, mix homogeneously, spraying is dried to obtain extract powder; Borneolum Syntheticum is put in pulverizer, be ground into fine powder; Extract powder and Borneolum Syntheticum fine powder are mixed to get to principal agent powder by equivalent incremental method.Get Pu Luoshamu 407 300g, LUTROL micro 68 MP 20g, benzalkonium bromide 2g, purified water 1600g.Pu Luoshamu 407, LUTROL micro 68 MP are added in pure water, be uniformly mixed to complete swelling, add benzalkonium bromide to be uniformly mixed, obtain thermosensitive hydrogel substrate.Principal agent powder is added to thermosensitive hydrogel substrate, be uniformly mixed the rear colloid mill mix homogeneously of crossing.Pack 50ml plastic bottle into, label, outer package.
The present embodiment is treated clinical 200 routine patients, wherein male 135 examples, female's 65 examples, wherein internal hemorrhoid 60 examples, external hemorrhoid 60 examples, mixed hemorrhoid 45 examples, anal fistula 20 examples, anal fissure 15 examples.Treat after 30 days, internal hemorrhoid is cured 60 examples; External hemorrhoid is cured 46 examples, and symptom obviously alleviates 4 examples; Mixed hemorrhoid is cured 35 examples, and symptom obviously alleviates 10 examples; Anal fistula symptom obviously alleviates 7 examples, and symptom alleviates 11 examples; Anal fissure symptom obviously alleviates 5 examples, and symptom alleviates 8 examples.Total effective rate reaches more than 90%.
Embodiment 3
Get respectively Radix Notoginseng 100g, Cortex Moutan 200g, Cortex Phellodendri 200g, Radix Sophorae Flavescentis 200g, Fructus Sophorae 150g, Galla Chinensis 100g, Borneolum Syntheticum 500g, Radix Notoginseng, Cortex Moutan, Cortex Phellodendri, Radix Sophorae Flavescentis, the Fructus Sophorae are ground into coarse powder, put in percolation filtration extraction pot, add 1 times of amount 70% soak with ethanol 24 hours, add 7 times of amount 70% ethanol percolations and obtain percolate, decompression recycling ethanol, concentrates to obtain extractum 1; Galla Chinensis is put in multi-function extractor, added 8 times of water gagings and decoct 2 times, merging filtrate, concentrating under reduced pressure obtains extractum 2; Merge extractum 1 and extractum 2, mix homogeneously, spraying is dried to obtain extract powder; Borneolum Syntheticum is put in pulverizer, be ground into fine powder; Extract powder and Borneolum Syntheticum fine powder are mixed to get to principal agent powder by equivalent incremental method.Get Pu Luoshamu 407 350g, LUTROL micro 68 MP 10g, benzalkonium bromide 4g, purified water 1600g.Pu Luoshamu 407, LUTROL micro 68 MP are added in pure water, be uniformly mixed to complete swelling, add benzalkonium bromide to be uniformly mixed, obtain thermosensitive hydrogel substrate.Principal agent powder is added to thermosensitive hydrogel substrate, be uniformly mixed the rear colloid mill mix homogeneously of crossing.Pack 50ml plastic bottle into, label, outer package.
The present embodiment is treated clinical 200 routine patients, wherein male 130 examples, female's 70 examples, wherein internal hemorrhoid 58 examples, external hemorrhoid 57 examples, mixed hemorrhoid 47 examples, anal fistula 22 examples, anal fissure 16 examples.Treat after 30 days, internal hemorrhoid is cured 58 examples; External hemorrhoid is cured 54 examples, and symptom obviously alleviates 3 examples; Mixed hemorrhoid is cured 36 examples, and symptom obviously alleviates 11 examples; Anal fistula symptom obviously alleviates 8 examples, and symptom alleviates 10 examples; Anal fissure symptom obviously alleviates 6 examples, and symptom alleviates 7 examples.Total effective rate reaches more than 90%.
Claims (2)
1. a preparation method for the treatment of the temperature sensitive gel of Chinese medicine of hemorrhoid, is characterized in that, preparation process is as follows:
(1), according to the percentage by weight of Radix Notoginseng, Cortex Moutan, Cortex Phellodendri, Radix Sophorae Flavescentis, the Fructus Sophorae, Galla Chinensis, Borneolum Syntheticum: 10-40%, 5-20%, 5-20%, 5-20%, 5-15%, 5-15%, 5-25%, draw materials;
(2), Radix Notoginseng, Cortex Moutan, Cortex Phellodendri, Radix Sophorae Flavescentis, the Fructus Sophorae are ground into coarse powder, put in percolation filtration extraction pot, add 70% soak with ethanol of 1 times of amount left and right about 24 hours, 70% ethanol percolation that adds 7 times of amounts left and right obtains percolate, decompression recycling ethanol, the concentrated extractum 1 that to obtain;
(3), Galla Chinensis is put in multi-function extractor, the decocting that adds 8 times of amounts left and right boils 2 times, merging filtrate, and concentrating under reduced pressure obtains extractum 2;
(4), merge extractum 1 and extractum 2, mix homogeneously, the dry extract powder that to obtain of spraying;
(5), Borneolum Syntheticum is put in pulverizer, be ground into fine powder;
(6), extract powder and Borneolum Syntheticum fine powder are mixed to get to the principal agent powder of this thermosensitive hydrogel by equivalent incremental method;
(7), Pu Luoshamu 407, LUTROL micro 68 MP are added in pure water, be uniformly mixed to complete swelling, add benzalkonium bromide to be uniformly mixed, obtain thermosensitive hydrogel substrate;
(8), principal agent powder is added in thermosensitive hydrogel substrate, be uniformly mixed the rear colloid mill mix homogeneously of crossing;
(9), specification in accordance with regulations bottle, label, outer package.
2. a preparation method for the temperature sensitive gel of Chinese medicine of the treatment hemorrhoid as described in right 1, is characterized in that,
Every 100 parts of medical materials are got Pu Luoshamu 407 30-40 parts, LUTROL micro 68 MP 1-5 part, benzalkonium bromide 0.4-1 part, 160 parts of mix homogeneously of purified water.
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Application publication date: 20141210 |
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RJ01 | Rejection of invention patent application after publication |