CN107137498B - Traditional Chinese medicine gel for treating haemorrhoids and preparation method thereof - Google Patents

Traditional Chinese medicine gel for treating haemorrhoids and preparation method thereof Download PDF

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CN107137498B
CN107137498B CN201710307646.8A CN201710307646A CN107137498B CN 107137498 B CN107137498 B CN 107137498B CN 201710307646 A CN201710307646 A CN 201710307646A CN 107137498 B CN107137498 B CN 107137498B
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gel
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chinese medicine
stirring
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CN107137498A (en
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张宇
李从福
郭志福
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Shenyang Rongyaotang Pharmaceutical Technology Co Ltd
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Abstract

The active ingredients of the traditional Chinese medicine gel for treating the hemorrhoids are prepared from the following raw materials in parts by weight: 20-30 parts of pseudo-ginseng, 40-60 parts of golden cypress, 40-60 parts of spearmint, 40-60 parts of sophora fruit, 20-30 parts of pepper, 3-7 parts of borneol, 2-6 parts of spearmint oil and 10-20 parts of glycerol. The invention is a natural plant extract, and has the functions of killing (inhibiting) bacteria, clearing heat and relieving pain, promoting blood circulation and removing blood stasis, eliminating swelling and promoting tissue regeneration, and relieving itching. Can be used for treating internal and external hemorrhoids caused by various factors without obvious clinical side effects. It prolongs the retention time of the medicine in the cavity, and has small irritation and comfortable use. The tolerance of the patient is good, and the carrying, the storage and the transportation are all very convenient.

Description

Traditional Chinese medicine gel for treating haemorrhoids and preparation method thereof
The technical field is as follows:
the invention relates to a traditional Chinese medicine gel for treating hemorrhoids and a preparation method thereof.
Background art:
hemorrhoids are common frequent diseases, including internal hemorrhoids, external hemorrhoids and mixed hemorrhoids, and are a chronic disease of a soft venous mass formed by varicose veins under the mucosa of the end of the rectum or under the anal canal and the anal periderm; when the force is continuously applied during defecation, the pressure in the veins is repeatedly increased, and the veins are enlarged. Women often suffer from hemorrhoids during pregnancy due to pelvic veins being compressed, which prevents blood circulation, and many obese people also suffer from hemorrhoids. If the hemorrhoid is suffered, the swollen and twisted vein wall in the anus becomes very thin, so the hemorrhoid is very easy to break when defecating, and thrombus is very easy to occur. When a thrombus occurs, blood in the hemorrhoid coagulates into a mass, causing pain. The related data show that the incidence rate of anorectal diseases is more than half, hemorrhoids account for more than half of all rectal diseases, and can cause anemia, infection and the like, and aggravate pain and illness.
The most common dosage forms in the market at present are suppositories and lotions, the traditional suppositories are administered in a solid form and melted or softened in the cavity, so that the use is inconvenient, the first pass effect of the medicine can be caused by slipping into the bottom of the rectum due to the difference of administration positions, and the lotion can relieve the disease condition to a certain extent, but the radical treatment is difficult. Modern medicine considers that the aim of treating hemorrhoids is to eliminate hemorrhoids without recurrence, but not just to relieve the main symptoms, so that hemorrhoids are radically cured by excision through an operation, and no even wrong drug treatment is needed, and the drugs have more side effects. The traditional Chinese medicine preparation is favored by doctors and patients due to small side effect and obvious curative effect, but has a plurality of defects, such as too frequent medication, certain irritation, intolerance of patients and the like, which bring inconvenience to the patients.
The invention content is as follows:
the purpose of the invention is as follows:
the invention provides a traditional Chinese medicine gel and a preparation method thereof, namely the traditional Chinese medicine gel for treating hemorrhoids and the preparation method thereof, and aims to solve the problems in the past.
The technical scheme is as follows:
a traditional Chinese medicine gel for treating hemorrhoids is characterized in that: the active ingredients of the medicine are prepared from the following raw materials in parts by weight: 20-30 parts of pseudo-ginseng, 40-60 parts of golden cypress, 40-60 parts of spearmint, 40-60 parts of sophora fruit, 20-30 parts of pepper, 3-7 parts of borneol, 2-6 parts of spearmint oil and 10-20 parts of glycerol.
The gel also needs other additives, 15-30 parts of gel matrix, 10-30 parts of PH regulator and ethanol.
The gel comprises preservative, and the preservative is not more than 1 part.
The gel matrix comprises one or more of acacia, gelatin, cellulose derivatives, chitosan, carbomer and polyvinyl alcohol; the preservative comprises one or more of sodium benzoate, ethylparaben and potassium sorbate; the pH regulator comprises one or more of triethanolamine and sodium hydroxide.
The gel matrix is carbomer, the preservative is ethylparaben, and the pH regulator is triethanolamine.
The carbomer is carbomer 940.
25 parts of pseudo-ginseng, 50 parts of phellodendron, 50 parts of spearmint, 50 parts of sophora fruit, 25 parts of pepper, 5 parts of borneol, 20 parts of glycerol, 4 parts of spearmint oil, 94020 parts of carbomer, 20 parts of triethanolamine, 0.2 part of ethylparaben and the balance of deionized water, and the 1000 parts of the traditional Chinese medicine is prepared.
The gel is an external anorectal gel, and when the anorectal gel is used, warm water is firstly used for cleaning the anus, then toilet paper or absorbent cotton is used for wiping the anus, then the anorectal gel is taken out and connected with a disposable insertion catheter, the anorectal gel is gently inserted, a hose is squeezed by hands to a proper amount, the catheter is taken out, and the anorectal gel is increased or decreased according to the condition 2-3 times a day.
The method for preparing the traditional Chinese medicine gel is characterized by comprising the following steps: the method comprises the following steps:
(1) preparing Notoginseng radix into 70-90 mesh powder;
(2) adding the prescription dose of gel matrix into purified water, hydrating for 15-25h, and allowing the gel matrix to fully swell to prepare 5-10% gel matrix sol;
(3) adding the glycerol in the formula amount to the step (2), stirring, and uniformly dispersing for later use;
(4) taking spearmint and pepper according to the prescription amount, adding 75% ethanol with the weight being seven times of that of the medicinal materials, refluxing for 1-1.5h at 85-90 ℃, filtering, collecting filtrate, wherein the amount of the collected filtrate is 2.5-3 times of the total mass of the spearmint and the pepper for later use;
(5) mixing the Chinese medicine residue obtained in the step (4) with the prescribed amount of pseudo-ginseng, golden cypress and sophora fruit, adding 75% ethanol, wherein the amount of the ethanol is 10 times of the amount of the added medicinal materials, namely pseudo-ginseng, golden cypress and sophora fruit, refluxing for 1-1.5h at 85-95 ℃, filtering, collecting an extracting solution, preserving, adding 8 times of 75% ethanol into the residue obtained after the operation, refluxing for 0.5-1h at 85-95 ℃, filtering, discarding the residue, and mixing the extracting solutions for later use;
(6) distilling the extracting solution obtained in the step (5) at 45-60 ℃ under reduced pressure for 1-1.5h until no alcohol smell exists, and then collecting the extracting solution which is 2.5-3 times of the amount of the spearmint, the pepper, the pseudo-ginseng, the golden cypress and the sophora fruit for later use;
(7) taking 40-70 parts of 95% ethanol, adding the borneol according to the prescription amount, stirring and dissolving, then adding the spearmint oil according to the prescription amount, and uniformly stirring for later use;
(8) adding the product obtained in the step (6) into the step (3), stirring the mixture into the step (3) while adding a small amount of the product for multiple times, and stirring uniformly; then adding the product obtained in the step (4) and stirring uniformly; and (4) adding the product obtained in the step (7), dispersing uniformly, adding a pH regulator in a prescription amount, fully and uniformly stirring, adding deionized water to the prescription amount, preparing 1000 parts, and uniformly stirring to obtain the water-based paint. (7) In the step, a preservative is added.
The advantages and effects are as follows:
the invention is a natural plant extract, and has the functions of killing (inhibiting) bacteria, clearing heat and relieving pain, promoting blood circulation and removing blood stasis, eliminating swelling and promoting tissue regeneration, and relieving itching. Can be used for treating internal and external hemorrhoids caused by various factors without obvious clinical side effects. It prolongs the retention time of the medicine in the cavity, and has small irritation and comfortable use. The tolerance of the patient is good, and the carrying, the storage and the transportation are all very convenient.
The specific implementation mode is as follows:
in order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail with reference to the following embodiments.
The gel has the characteristics of antibiosis, anti-inflammation, promotion of wound healing, nourishing and repairing of mucous membrane and the like, can improve the compliance of patients, has certain biological adhesion, can avoid the first-pass effect of the medicine, has good biocompatibility, is biodegradable, safe and nontoxic, and is concerned by the medical field in recent years and obtains satisfactory curative effect when being applied to clinic.
Example 1:
preferred amounts are: 25 parts of pseudo-ginseng, 50 parts of golden cypress, 50 parts of sophora fruit, 50 parts of spearmint, 25 parts of pepper, 20 parts of glycerol, 20 parts of carbomer, 5 parts of borneol, 20 parts of triethanolamine, 4 parts of spearmint oil and 0.2 part of ethylparaben.
Preparing Notoginseng radix into 80 mesh powder;
(1) 20 parts of Carbomer940 is added into pure water, and the mixture is hydrated for 20 hours and fully swelled to prepare 8 percent Carbomer940 sol.
(2) Adding the glycerol of the formula amount into the mixture (1), stirring, and uniformly dispersing for later use.
(3) Adding 75% ethanol (7 times of the amount of the medicinal materials) into the spearmint and the pepper according to the prescription amount, refluxing for 1h at 90 ℃, and filtering to obtain filtrate (the collection amount is 2.5-3 times of the amount of the medicinal materials) for later use.
(4) Mixing the residue of (3) with Notoginseng radix, cortex Phellodendri and fructus Sophorae, adding 75% ethanol (10 times of the total mass of Notoginseng radix, cortex Phellodendri and fructus Sophorae), refluxing at 90 deg.C for 1 hr, filtering, collecting extractive solution, and storing. Adding 75% ethanol (8 times of total mass of Notoginseng radix, cortex Phellodendri, and fructus Sophorae) into the residue, refluxing at 90 deg.C for 0.5h, filtering, discarding residue, and mixing extractive solutions.
(5) And (3) distilling the extract obtained in the step (4) at 50 ℃ under reduced pressure for 1h until no alcohol smell exists (the collection amount is 2.5-3 times of the amount of the medicinal materials), and keeping the extract for later use.
(6) 50 parts of 95% ethanol is taken, added with the borneol according to the prescription amount, stirred and dissolved, and then added with 4 parts of spearmint oil and stirred evenly for standby.
(7) Adding (5) into the mixture (2) (stirring the mixture into the mixture (2) while adding a small amount of the mixture for multiple times), and stirring uniformly; adding the (3) and stirring uniformly; and (6) adding the triethanolamine, uniformly dispersing, adding the triethanolamine according to the prescription amount, fully and uniformly stirring, adding water according to the prescription amount, and uniformly stirring to obtain the triethanolamine-modified polyvinyl alcohol.
Example 2:
preferred amounts are: 20 parts of pseudo-ginseng, 50 parts of golden cypress, 40 parts of sophora fruit, 40 parts of spearmint, 20 parts of pepper, 10 parts of glycerol, 15 parts of carbomer, 5 parts of borneol, 10 parts of triethanolamine, 4 parts of spearmint oil and 0.2 part of ethylparaben.
Preparing the pseudo-ginseng into 70-mesh powder for later use;
(1) adding 15 parts of Carbomer (Carbomer)940 into purified water, hydrating for 15 hr, and allowing it to swell sufficiently to obtain 6% Carbomer (Carbomer)940 sol.
(2) Adding 10 parts of glycerol into the mixture obtained in the step (1), stirring and uniformly dispersing the mixture for later use;
(3) adding 40 parts of spearmint and 20 parts of pepper into 75% ethanol, wherein the amount of the ethanol added is 7 times of the total mass of the spearmint and the pepper, refluxing for 1 hour at 90 ℃, filtering, collecting filtrate, and the amount of the collected filtrate is 2.5 times of the total mass of the spearmint and the pepper for later use;
(4) mixing the Chinese medicine residue obtained in the step (3) with 20 parts of pseudo-ginseng, 50 parts of golden cypress and 40 parts of sophora fruit, adding 75% ethanol, wherein the amount of the ethanol is 10 times of the total mass of the later added medicinal materials, namely pseudo-ginseng, golden cypress and sophora fruit, refluxing for 1.5h at 85 ℃, filtering, collecting an extracting solution, storing the extracting solution, adding 75% ethanol into the residue obtained after the above procedure, wherein the amount of the ethanol is 8 times of the total mass of the pseudo-ginseng, golden cypress and sophora fruit, refluxing for 0.5h at 85 ℃, filtering, discarding the residue, and mixing the extracting solutions for later use;
(5) distilling the extract obtained in step (4) at 45 deg.C under reduced pressure for 1 hr until no alcohol smell exists, and collecting to 3 times of the total amount of herba Menthae Rotundifoliae, fructus Zanthoxyli, Notoginseng radix, cortex Phellodendri and fructus Sophorae;
(6) taking 70 parts of 95% ethanol, adding 3 parts of borneol and 0.2 part of ethylparaben according to the prescription amount, stirring and dissolving, then adding 4 parts of spearmint oil, and uniformly stirring for later use;
(7) adding the product obtained in the step (5) into the step (2), stirring the mixture into the step (2) while adding a small amount of the product for multiple times, and stirring uniformly; then adding the product obtained in the step (3) and stirring uniformly; and (4) adding the product obtained in the step (6), dispersing uniformly, adding 10 parts of triethanolamine, fully and uniformly stirring, adding water to the amount of the prescription, namely 1000 parts, and uniformly stirring to obtain the finished product.
Example 3:
preferred amounts are: 25 parts of pseudo-ginseng, 40 parts of golden cypress, 50 parts of sophora fruit, 50 parts of spearmint, 25 parts of pepper, 20 parts of glycerin, 20 parts of carbomer, 3 parts of borneol, 20 parts of triethanolamine and 3 parts of spearmint oil.
Preparing Notoginseng radix into 80 mesh powder;
(1) 20 parts of Carbomer (Carbomer)940 is added into purified water, hydrated for 20h and fully swelled to prepare 8% Carbomer (Carbomer)940 sol.
(2) Adding 20 parts of glycerol into the mixture obtained in the step (1), stirring, and uniformly dispersing for later use;
(3) adding 50 parts of spearmint and 25 parts of pepper into 75% ethanol, wherein the amount of the ethanol is 7 times of the total mass of the spearmint and the pepper, refluxing for 1.5h at 85 ℃, filtering, collecting filtrate, and the amount of the collected filtrate is 3 times of the total mass of the spearmint and the pepper for later use;
(4) mixing the Chinese medicine residue obtained in the step (3) with 25 parts of pseudo-ginseng, 40 parts of golden cypress and 50 parts of sophora fruit, adding 75% ethanol, wherein the amount of the ethanol is 10 times of the total mass of the later added medicinal materials, namely pseudo-ginseng, golden cypress and sophora fruit, refluxing for 1h at 90 ℃, filtering, collecting an extracting solution, storing the extracting solution, adding 75% ethanol into the residue obtained after the above procedure, wherein the amount of the ethanol is 8 times of the total mass of the pseudo-ginseng, golden cypress and sophora fruit, refluxing for 1h at 95 ℃, filtering, discarding the residue, and mixing the extracting solutions for later use;
(5) distilling the extract obtained in step (4) at 50 deg.C under reduced pressure for 1.5 hr until no alcohol smell exists, collecting to 2.5 times of the total amount of herba Menthae Rotundifoliae, fructus Zanthoxyli, Notoginseng radix, cortex Phellodendri and fructus Sophorae, and keeping;
(6) taking 60 parts of 95% ethanol, adding 3 parts of borneol, stirring for dissolving, then adding 3 parts of spearmint oil, and uniformly stirring for later use;
(7) adding the product obtained in the step (5) into the step (2), stirring the mixture into the step (2) while adding a small amount of the product for multiple times, and stirring uniformly; then adding the product obtained in the step (3) and stirring uniformly; and (4) adding the product obtained in the step (6), dispersing uniformly, adding 20 parts of triethanolamine, fully and uniformly stirring, adding water to the amount of the prescription, namely 1000 parts, and uniformly stirring to obtain the finished product.
Example 4:
preferred amounts are: 30 parts of pseudo-ginseng, 60 parts of golden cypress, 60 parts of sophora fruit, 60 parts of spearmint, 30 parts of pepper, 30 parts of glycerol, 30 parts of carbomer, 3 parts of borneol, 20 parts of triethanolamine, 2 parts of spearmint oil and 0.4 part of ethylparaben.
Preparing the pseudo-ginseng into 90-mesh powder for later use;
(1) adding 30 parts of Carbomer (Carbomer)940 into purified water, hydrating for 25 hr, and allowing it to swell sufficiently to obtain 10% Carbomer (Carbomer)940 sol.
(2) Adding 30 parts of glycerol into the mixture obtained in the step (1), stirring, and uniformly dispersing for later use;
(3) adding 60 parts of spearmint and 30 parts of pepper into 75% ethanol, wherein the amount of the ethanol is 7 times of the total mass of the spearmint and the pepper, refluxing for 1.5h at 85 ℃, filtering, collecting filtrate, and the amount of the collected filtrate is 2.5 times of the total mass of the spearmint and the pepper for later use;
(4) mixing the Chinese medicine residue obtained in the step (3) with 30 parts of pseudo-ginseng, 60 parts of golden cypress and 60 parts of sophora fruit, adding 75% ethanol, wherein the amount of the ethanol is 10 times of the total mass of the later added medicinal materials, namely pseudo-ginseng, golden cypress and sophora fruit, refluxing for 1h at 95 ℃, filtering, collecting an extracting solution, storing the extracting solution, adding 75% ethanol into the residue obtained after the above procedure, wherein the amount of the ethanol is 8 times of the total mass of the pseudo-ginseng, golden cypress and sophora fruit, refluxing for 1h at 90 ℃, filtering, discarding the residue, and mixing the extracting solutions for later use;
(5) distilling the extract in step (4) at 60 deg.C under reduced pressure for 1.5 hr until no alcohol smell exists, collecting the extract 2.5 times of the total amount of herba Menthae Rotundifoliae, fructus Zanthoxyli, Notoginseng radix, cortex Phellodendri and fructus Sophorae, and keeping;
(6) taking 50 parts of 95% ethanol, adding 3 parts of borneol and 0.4 part of ethylparaben according to the prescription amount, stirring and dissolving, then adding 2 parts of spearmint oil, and uniformly stirring for later use;
(7) adding the product obtained in the step (5) into the step (2), stirring the mixture into the step (2) while adding a small amount of the product for multiple times, and stirring uniformly; then adding the product obtained in the step (3) and stirring uniformly; and (4) adding the product obtained in the step (6), dispersing uniformly, adding 30 parts of triethanolamine, fully and uniformly stirring, adding water to the amount of the prescription, namely 1000 parts, and uniformly stirring to obtain the finished product.
Example 5:
preferred amounts are: 30 parts of pseudo-ginseng, 60 parts of golden cypress, 55 parts of sophora fruit, 43 parts of spearmint, 30 parts of pepper, 30 parts of glycerol, 30 parts of Arabic gum, 7 parts of borneol, 30 parts of sodium hydroxide, 6 parts of spearmint oil and 0.4 part of sodium benzoate.
Preparing the pseudo-ginseng into 90-mesh powder for later use;
(1) adding Arabic gum into purified water, hydrating for 15 hr, and swelling to obtain 5% Arabic gum sol.
(2) Adding glycerol into the mixture obtained in the step (1), stirring and uniformly dispersing for later use;
(3) adding spearmint and pepper into 75% ethanol, wherein the amount of the ethanol is 7 times of the total mass of the spearmint and the pepper, refluxing for 1.5h at 85 ℃, filtering, collecting filtrate, and the amount of the collected filtrate is 2.8 times of the total mass of the spearmint and the pepper for later use;
(4) mixing the Chinese medicine residue obtained in the step (3) with the pseudo-ginseng, the golden cypress and the sophora fruit, adding 75% ethanol, wherein the amount of the ethanol is 10 times of the total mass of the later added medicinal materials, namely the pseudo-ginseng, the golden cypress and the sophora fruit, refluxing for 1h at 95 ℃, filtering, collecting an extracting solution, preserving, adding 75% ethanol into the residue obtained after the above procedure, wherein the amount of the ethanol is 8 times of the total mass of the pseudo-ginseng, the golden cypress and the sophora fruit, refluxing for 1h at 90 ℃, filtering, removing the residue, and mixing the extracting solutions for later use;
(5) distilling the extract in step (4) at 60 deg.C under reduced pressure for 1.5 hr until no alcohol smell exists, collecting the extract 2.5 times of the total amount of herba Menthae Rotundifoliae, fructus Zanthoxyli, Notoginseng radix, cortex Phellodendri and fructus Sophorae, and keeping;
(6) taking 40 parts of 95% ethanol, adding the borneol and the sodium benzoate according to the prescription amount, stirring and dissolving, then adding the spearmint oil, and stirring uniformly for later use;
(7) adding the product obtained in the step (5) into the step (2), stirring the mixture into the step (2) while adding a small amount of the product for multiple times, and stirring uniformly; then adding the product obtained in the step (3) and stirring uniformly; and (4) adding the product obtained in the step (6), dispersing uniformly, adding sodium hydroxide, fully and uniformly stirring, adding water to the amount of 1000 parts according to the prescription, and uniformly stirring to obtain the water-based paint.
Example 6:
preferred amounts are: 28 parts of pseudo-ginseng, 52 parts of golden cypress, 55 parts of sophora fruit, 43 parts of spearmint, 30 parts of pepper, 18 parts of glycerol, 30 parts of total gelatin, chitosan and polyvinyl alcohol, 7 parts of borneol, 30 parts (equal parts) of total sodium hydroxide and triethanolamine, 6 parts of spearmint oil and 0.4 part of potassium sorbate.
Preparing the pseudo-ginseng into 70-mesh powder for later use;
(1) adding gelatin, chitosan and polyvinyl alcohol into purified water, hydrating for 15h, and swelling to obtain 9% sol.
(2) Adding glycerol into the mixture obtained in the step (1), stirring and uniformly dispersing for later use;
(3) adding spearmint and pepper into 75% ethanol, wherein the amount of the ethanol is 7 times of the total mass of the spearmint and the pepper, refluxing for 1.5h at 85 ℃, filtering, collecting filtrate, and the amount of the collected filtrate is 2.8 times of the total mass of the spearmint and the pepper for later use;
(4) mixing the Chinese medicine residue obtained in the step (3) with the pseudo-ginseng, the golden cypress and the sophora fruit, adding 75% ethanol, wherein the amount of the ethanol is 10 times of the total mass of the later added medicinal materials, namely the pseudo-ginseng, the golden cypress and the sophora fruit, refluxing for 1h at 95 ℃, filtering, collecting an extracting solution, preserving, adding 75% ethanol into the residue obtained after the above procedure, wherein the amount of the ethanol is 8 times of the total mass of the pseudo-ginseng, the golden cypress and the sophora fruit, refluxing for 1h at 90 ℃, filtering, removing the residue, and mixing the extracting solutions for later use;
(5) distilling the extract in step (4) at 60 deg.C under reduced pressure for 1.5 hr until no alcohol smell exists, collecting the extract 2.5 times of the total amount of herba Menthae Rotundifoliae, fructus Zanthoxyli, Notoginseng radix, cortex Phellodendri and fructus Sophorae, and keeping;
(6) taking 40 parts of 95% ethanol, adding borneol and potassium sorbate according to the prescription amount, stirring and dissolving, then adding spearmint oil, and stirring uniformly for later use;
(7) adding the product obtained in the step (5) into the step (2), stirring the mixture into the step (2) while adding a small amount of the product for multiple times, and stirring uniformly; then adding the product obtained in the step (3) and stirring uniformly; and (4) adding the product obtained in the step (6), dispersing uniformly, adding sodium hydroxide and triethanolamine, fully and uniformly stirring, adding water to the amount of the prescription, namely 1000 parts, and uniformly stirring to obtain the water-based oil.
Example 7:
preferred amounts are: 28 parts of pseudo-ginseng, 52 parts of golden cypress, 55 parts of sophora fruit, 43 parts of spearmint, 30 parts of pepper, 18 parts of glycerol, 30 parts of hydroxypropyl methyl cellulose, 7 parts of borneol, 20 parts (even division) of the total of sodium hydroxide and triethanolamine, 6 parts of spearmint oil and 0.4 part (even division) of the total of potassium sorbate and ethylparaben.
Preparing the pseudo-ginseng into 70-mesh powder for later use;
(1) adding hydroxypropyl methyl cellulose into purified water, hydrating for 15h, and swelling to obtain 9% sol.
(2) Adding glycerol into the mixture obtained in the step (1), stirring and uniformly dispersing for later use;
(3) adding spearmint and pepper into 75% ethanol, wherein the amount of the ethanol is 7 times of the total mass of the spearmint and the pepper, refluxing for 1.5h at 85 ℃, filtering, collecting filtrate, and the amount of the collected filtrate is 2.8 times of the total mass of the spearmint and the pepper for later use;
(4) mixing the Chinese medicine residue obtained in the step (3) with the pseudo-ginseng, the golden cypress and the sophora fruit, adding 75% ethanol, wherein the amount of the ethanol is 10 times of the total mass of the later added medicinal materials, namely the pseudo-ginseng, the golden cypress and the sophora fruit, refluxing for 1h at 95 ℃, filtering, collecting an extracting solution, preserving, adding 75% ethanol into the residue obtained after the above procedure, wherein the amount of the ethanol is 8 times of the total mass of the pseudo-ginseng, the golden cypress and the sophora fruit, refluxing for 1h at 90 ℃, filtering, removing the residue, and mixing the extracting solutions for later use;
(5) distilling the extract in step (4) at 60 deg.C under reduced pressure for 1.5 hr until no alcohol smell exists, collecting the extract 2.5 times of the total amount of herba Menthae Rotundifoliae, fructus Zanthoxyli, Notoginseng radix, cortex Phellodendri and fructus Sophorae, and keeping;
(6) taking 40 parts of 95% ethanol, adding borneol, potassium sorbate and ethylparaben according to the prescription amount, stirring for dissolving, then adding spearmint oil, and stirring uniformly for later use;
(7) adding the product obtained in the step (5) into the step (2), stirring the mixture into the step (2) while adding a small amount of the product for multiple times, and stirring uniformly; then adding the product obtained in the step (3) and stirring uniformly; and (4) adding the product obtained in the step (6), dispersing uniformly, adding sodium hydroxide and triethanolamine, fully and uniformly stirring, adding water to the amount of the prescription, namely 1000 parts, and uniformly stirring to obtain the water-based oil.
Example 8:
preferred amounts are: 30 parts of pseudo-ginseng, 60 parts of golden cypress, 55 parts of sophora fruit, 43 parts of spearmint, 30 parts of pepper, 30 parts of glycerol, 30 parts of carboxymethyl cellulose, 7 parts of borneol, 30 parts of sodium hydroxide, 6 parts of spearmint oil and 0.4 part of sodium benzoate.
Preparing the pseudo-ginseng into 90-mesh powder for later use;
(1) adding carboxymethyl cellulose into purified water, hydrating for 15 hr to swell fully and obtain 5% sol.
(2) Adding glycerol into the mixture obtained in the step (1), stirring and uniformly dispersing for later use;
(3) adding spearmint and pepper into 75% ethanol, wherein the amount of the ethanol is 7 times of the total mass of the spearmint and the pepper, refluxing for 1.5h at 85 ℃, filtering, collecting filtrate, and the amount of the collected filtrate is 2.8 times of the total mass of the spearmint and the pepper for later use;
(4) mixing the Chinese medicine residue obtained in the step (3) with the pseudo-ginseng, the golden cypress and the sophora fruit, adding 75% ethanol, wherein the amount of the ethanol is 10 times of the total mass of the later added medicinal materials, namely the pseudo-ginseng, the golden cypress and the sophora fruit, refluxing for 1h at 95 ℃, filtering, collecting an extracting solution, preserving, adding 75% ethanol into the residue obtained after the above procedure, wherein the amount of the ethanol is 8 times of the total mass of the pseudo-ginseng, the golden cypress and the sophora fruit, refluxing for 1h at 90 ℃, filtering, removing the residue, and mixing the extracting solutions for later use;
(5) distilling the extract in step (4) at 60 deg.C under reduced pressure for 1.5 hr until no alcohol smell exists, collecting the extract 2.5 times of the total amount of herba Menthae Rotundifoliae, fructus Zanthoxyli, Notoginseng radix, cortex Phellodendri and fructus Sophorae, and keeping;
(6) taking 40 parts of 95% ethanol, adding the borneol and the sodium benzoate according to the prescription amount, stirring and dissolving, then adding the spearmint oil, and stirring uniformly for later use;
(7) adding the product obtained in the step (5) into the step (2), stirring the mixture into the step (2) while adding a small amount of the product for multiple times, and stirring uniformly; then adding the product obtained in the step (3) and stirring uniformly; and (4) adding the product obtained in the step (6), dispersing uniformly, adding sodium hydroxide, fully and uniformly stirring, adding water to the amount of 1000 parts according to the prescription, and uniformly stirring to obtain the water-based paint.
Example 9:
preferred amounts are: 30 parts of pseudo-ginseng, 60 parts of golden cypress, 60 parts of sophora fruit, 60 parts of spearmint, 30 parts of pepper, 30 parts of glycerol, 30 parts of hydroxyethyl cellulose, 3 parts of borneol, 20 parts of triethanolamine, 2 parts of spearmint oil and 0.4 part of ethylparaben.
Preparing the pseudo-ginseng into 90-mesh powder for later use;
(1) and adding 30 parts of hydroxyethyl cellulose into purified water, hydrating for 25 hours, and fully swelling to prepare 10% hydroxyethyl cellulose sol.
(2) Adding 30 parts of glycerol into the mixture obtained in the step (1), stirring, and uniformly dispersing for later use;
(3) adding 60 parts of spearmint and 30 parts of pepper into 75% ethanol, wherein the amount of the ethanol is 7 times of the total mass of the spearmint and the pepper, refluxing for 1.5h at 85 ℃, filtering, collecting filtrate, and the amount of the collected filtrate is 2.5 times of the total mass of the spearmint and the pepper for later use;
(4) mixing the Chinese medicine residue obtained in the step (3) with 30 parts of pseudo-ginseng, 60 parts of golden cypress and 60 parts of sophora fruit, adding 75% ethanol, wherein the amount of the ethanol is 10 times of the total mass of the later added medicinal materials, namely pseudo-ginseng, golden cypress and sophora fruit, refluxing for 1h at 95 ℃, filtering, collecting an extracting solution, storing the extracting solution, adding 75% ethanol into the residue obtained after the above procedure, wherein the amount of the ethanol is 8 times of the total mass of the pseudo-ginseng, golden cypress and sophora fruit, refluxing for 1h at 90 ℃, filtering, discarding the residue, and mixing the extracting solutions for later use;
(5) distilling the extract in step (4) at 60 deg.C under reduced pressure for 1.5 hr until no alcohol smell exists, collecting the extract 2.5 times of the total amount of herba Menthae Rotundifoliae, fructus Zanthoxyli, Notoginseng radix, cortex Phellodendri and fructus Sophorae, and keeping;
(6) taking 50 parts of 95% ethanol, adding 3 parts of borneol and 0.4 part of ethylparaben according to the prescription amount, stirring and dissolving, then adding 2 parts of spearmint oil, and uniformly stirring for later use;
(7) adding the product obtained in the step (5) into the step (2), stirring the mixture into the step (2) while adding a small amount of the product for multiple times, and stirring uniformly; then adding the product obtained in the step (3) and stirring uniformly; and (4) adding the product obtained in the step (6), dispersing uniformly, adding 30 parts of triethanolamine, fully and uniformly stirring, adding water to the amount of the prescription, namely 1000 parts, and uniformly stirring to obtain the finished product.
The clinical practice is as follows:
in a certain anorectal hospital, 8 patients with hemorrhoids, 3 of which were internal hemorrhoids, 3 of which were external hemorrhoids, and 2 of which were mixed hemorrhoids, were identified as follows:
Figure BDA0001285434030000151
Figure BDA0001285434030000161
Figure BDA0001285434030000171
the above-mentioned administration process has not seen obvious minus effect.
In conclusion, the three internal hemorrhoid groups in the table are completely cured, the two external hemorrhoid groups in the table are cured, the clinical symptom of one person is obviously relieved, the two mixed hemorrhoid groups in the table are cured, and the symptom of one person is obviously relieved.

Claims (10)

1. A traditional Chinese medicine gel for treating hemorrhoids is characterized in that: the active ingredients of the medicine are prepared from the following raw materials in parts by weight: 20-30 parts of pseudo-ginseng, 40-60 parts of golden cypress, 40-60 parts of spearmint, 40-60 parts of sophora fruit, 20-30 parts of pepper, 3-7 parts of borneol, 2-6 parts of spearmint oil and 10-30 parts of glycerol.
2. The traditional Chinese medicine gel for treating hemorrhoids according to claim 1, which is characterized in that: the gel also needs other additives, 15-30 parts of gel matrix, 10-30 parts of pH regulator and ethanol.
3. The traditional Chinese medicine gel for treating hemorrhoids according to claim 2, which is characterized in that: the gel also comprises a preservative, and the preservative is not more than 1 part.
4. The traditional Chinese medicine gel for treating hemorrhoids according to claim 2 or 3, which is characterized in that: the gel matrix comprises one or more of acacia, gelatin, chitosan, carbomer and polyvinyl alcohol; the preservative comprises one or more of sodium benzoate, ethylparaben and potassium sorbate; the pH regulator comprises one or more of triethanolamine and sodium hydroxide.
5. The traditional Chinese medicine gel for treating hemorrhoids according to claim 4, which is characterized in that: the gel matrix is carbomer, the preservative is ethylparaben, and the pH regulator is triethanolamine.
6. The traditional Chinese medicine gel for treating hemorrhoids according to claim 5, which is characterized in that: the carbomer is carbomer 940.
7. The traditional Chinese medicine gel for treating hemorrhoids according to claim 6, which is characterized in that: 25 parts of pseudo-ginseng, 50 parts of phellodendron, 50 parts of spearmint, 50 parts of sophora fruit, 25 parts of pepper, 5 parts of borneol, 20 parts of glycerol, 4 parts of spearmint oil, 94020 parts of carbomer, 20 parts of triethanolamine, 0.2 part of ethylparaben and the balance of deionized water, and the 1000 parts of the traditional Chinese medicine is prepared.
8. The traditional Chinese medicine gel for treating hemorrhoids according to claim 1, which is characterized in that: the gel is an external anorectal gel, and when the anorectal gel is used, warm water is firstly used for cleaning the anus, then toilet paper or absorbent cotton is used for wiping the anus, then the anorectal gel is taken out and connected with a disposable insertion catheter, the anorectal gel is gently inserted, a hose is squeezed by hands to a proper amount, the catheter is taken out, and the anorectal gel is added or reduced 2-3 times a day according to the situation.
9. A method for preparing the traditional Chinese medicine gel of claim 2 or 3, which is characterized by comprising the following steps: the method comprises the following steps:
(1) preparing Notoginseng radix into 70-90 mesh powder;
(2) adding the prescription dose of gel matrix into purified water, hydrating for 15-25h, and allowing the gel matrix to fully swell to prepare 5-10% gel matrix sol;
(3) adding the glycerol in the formula amount to the step (2), stirring, and uniformly dispersing for later use;
(4) taking spearmint and pepper according to the prescription amount, adding 75% ethanol with the weight being seven times of that of the medicinal materials, refluxing for 1-1.5h at 85-90 ℃, filtering, and collecting filtrate, wherein the amount of the collected filtrate is 2.5-3 times of the total mass of the spearmint and the pepper for later use;
(5) mixing the Chinese medicine residue obtained in the step (4) with the prescribed amount of pseudo-ginseng, golden cypress and sophora fruit, adding 75% ethanol, wherein the amount of the ethanol is 10 times of the amount of the added medicinal materials, namely pseudo-ginseng, golden cypress and sophora fruit, refluxing for 1-1.5h at 85-95 ℃, filtering, collecting an extracting solution, preserving, adding 8 times of 75% ethanol into the residue obtained after the operation, refluxing for 0.5-1h at 85-95 ℃, filtering, discarding the residue, and mixing the extracting solutions for later use;
(6) distilling the extracting solution obtained in the step (5) at 45-60 ℃ under reduced pressure for 1-1.5h until no alcohol smell exists, and then collecting the extracting solution which is 2.5-3 times of the amount of the spearmint, the pepper, the pseudo-ginseng, the golden cypress and the sophora fruit for later use;
(7) taking 40-70 parts of 95% ethanol, adding the borneol according to the prescription amount, stirring and dissolving, then adding the spearmint oil according to the prescription amount, and uniformly stirring for later use;
(8) adding the product obtained in the step (6) into the step (3), stirring the mixture into the step (3) while adding a small amount of the product for multiple times, and stirring uniformly; then adding the product obtained in the step (4) and stirring uniformly; and (4) adding the product obtained in the step (7), dispersing uniformly, adding a pH regulator in a prescription amount, fully and uniformly stirring, adding deionized water to the prescription amount, preparing 1000 parts, and uniformly stirring to obtain the water-based paint.
10. The preparation method of the traditional Chinese medicine gel according to claim 9, which is characterized in that: (7) in the step, a preservative is added.
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