CN106692307B - Hydrogel for treating female cervical erosion and preparation method thereof - Google Patents
Hydrogel for treating female cervical erosion and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a hydrogel for treating female cervical erosion, which mainly comprises natural medicines, wherein the natural medicines comprise the following components in parts by weight: and (3) rhizoma bletillae polysaccharide: 1.5-7.0 parts; sea buckthorn oil: 5.0-10.0 parts; and (3) forsythia oil: 0.5-2.0 parts; angelica oil: 0.5-2.0 parts; total asiaticoside: 1.0 to 5.0 parts. The hydrogel provided by the invention is prepared by the steps of mixing, dissolving, stirring/emulsifying, encapsulating and the like of materials, has the effects of removing putrefaction, promoting granulation, detoxifying, eliminating dampness, relieving swelling and pain, removing blood stasis and expelling pus, and has the exact effect of treating both symptoms and root causes for female cervical erosion through the ways of resisting bacteria and viruses, diminishing inflammation, relieving pain, promoting mucous membrane repair and renewal, improving mucous membrane disease resistance, reducing cervical secretions, improving vaginal cleanliness, restoring balance of beneficial bacteria flora in vagina and the like.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a natural medicine hydrogel for treating female cervical erosion and a preparation method thereof.
Background
Cervical erosion is a common disease and frequently-occurring disease, because various chronic inflammations stimulate the local part of the cervix for a long time, the squamous epithelial tissue on the surface of the cervical vagina part is lost and covered by columnar epithelium, and the columnar epithelium at the pathological change part is thinner than the squamous epithelium, so the resistance to pathogens is reduced, and the main symptoms are manifested as leukorrhagia, whitish or yellow, or pus and waist and abdomen heaving; the incidence of cervical erosion accounts for about 60% of the gynecological outpatient service, pelvic inflammation, infertility, premature birth, neonatal infection and the like can be caused, even cervical canceration can be caused by repeated infection stimulation, therefore, the harm is great, and great psychological and physiological harm is brought to patients. The etiology of cervical erosion is complex and various, and is related to various factors such as physical and chemical stimulation and injury, bacterial infection, protozoan infection, viral infection and the like; in addition, cervical erosion is related to the age of patients, and the main reason is that the estrogen level in young women is high, the columnar epithelium of the cervical canal mucous membrane is moved outwards to the cervical vagina under the action of estrogen, and the columnar epithelium layer of the cervical canal mucous membrane is thin and weak in resistance, so that the cervical canal mucous membrane is easy to infect after being damaged.
the traditional Chinese medicine gel preparation is a gel preparation which is used for restoring the immunologic function of the cervical part of a human body through medicines, and further reactivating the immunologic function of the human body to kill pathogens so as to cure the cervical erosion, the operation treatment mainly aims at severe cervical erosion which needs long treatment course and has poor effect of the physical treatment and the medicine treatment, and a high-frequency electric wave knife (L EEP knife) is a new technology which is developed in recent years, and utilizes high heat generated by contacting the body with electric waves to finish cutting and treating the cervical erosion, but the physical treatment needs a special device and a special medical treatment technology, and the high-frequency electric wave knife (L EEP knife) is a special gel preparation which is difficult to cause the toxic effect of a vaginal infection, particularly has a low toxic effect and side effect on the cervical erosion caused by the repeated and slow release of a special vaginal infection, and has a low probability of causing the cervical erosion, and has a low probability of toxic and side effect on the cervical erosion of a cervical erosion caused by the repeated and serious vaginal infection.
At present, the main auxiliary materials for preparing the hydrogel comprise synthetic and natural water-soluble polymers, wherein the synthetic polymers comprise carbomer, water-soluble cellulose, povidone, polyvinyl alcohol and the like, but residual monomers and organic solvents in the synthetic or semi-synthetic polymers can be one of factors causing some adverse reactions; natural polymers are safe and reliable, and thus, natural polymers have been the focus of research for preparing gels in recent years. For example, the bletilla polysaccharide is water-soluble high-molecular viscous polysaccharide extracted from natural medicine bletilla, has the average molecular weight of 65000-150000 kDa, and can form viscous gel liquid when dissolved in water, thereby having good biological adhesion; in addition, the bletilla polysaccharide has wide pharmacological activities of ulcer resistance, inflammation resistance, hemostasis and the like, is safe and non-toxic to a human body, and therefore, has been widely used as a medical auxiliary material, a biological material, a cosmetic auxiliary material and the like since ancient times. The invention takes bletilla polysaccharide as a high molecular auxiliary material for preparing hydrogel, prepares a hydrogel preparation compatible with the effective parts of the traditional Chinese medicinal materials, and provides a new technical means which is convenient to use, safe and comfortable, treats both principal and secondary aspect of disease, has reliable curative effect and no tolerance for the effective treatment of the female cervical erosion, so that the invention has important social significance and clinical application value.
Disclosure of Invention
The invention aims to provide a natural medicinal hydrogel preparation for treating female cervical erosion, which solves the defects that the existing physical therapy needs special instruments and special technology, and patients can not treat the female cervical erosion independently so as to reduce the compliance of the patients; solves the defects that the surgical therapy can cause petal-shaped columnar epithelial hyperplasia near the external cervical orifice and postoperative cervical canal stenosis; the defects that the drug resistance of pathogenic bacteria is caused by antibiotics, the incidence rate of adverse reaction is increased by combined medication, and the maladjustment of probiotics flora which damages the environment in the vagina is caused, so that the disease resistance of the vagina is lower and the disease is easier to occur are overcome; also overcomes the defects of the traditional Chinese medicine solid preparation that the dosage form is rough and the impurity content is higher, which can generate mechanical stimulation to the vagina mucosa, and the liquid preparation has strong fluidity, short detention time in the vagina and poor curative effect.
Specifically, the main component of the hydrogel for treating female cervical erosion provided by the invention is a natural medicine, and the natural medicine comprises the following components in parts by weight:
And (3) rhizoma bletillae polysaccharide: 1.5-7.0 parts; sea buckthorn oil: 5.0-10.0 parts; and (3) forsythia oil: 0.5-2.0 parts; angelica oil: 0.5-2.0 parts; total asiaticoside: 1.0 to 5.0 parts.
Preferably, the hydrogel for treating female cervical erosion provided by the invention comprises the following raw materials in parts by weight: and (3) rhizoma bletillae polysaccharide: 1.5-7.0 parts; sea buckthorn oil: 5.0-10.0 parts; and (3) forsythia oil: 0.5-2.0 parts; angelica oil: 0.5-2.0 parts; total asiaticoside: 1.0-5.0 parts; 0.02-0.15 parts of a preservative; 73.85-91.48 parts of purified water.
Preferably, the preservative is one of or a combination of chlorhexidine acetate, ethyl paraben, propyl paraben and butyl paraben.
More preferably, the preservative is prepared from a mixture of 1: 1 of ethylparaben and propylparaben.
More preferably, the preservative is prepared from a mixture of 4: 1 of ethylparaben and butylparaben.
Preferably, the invention also provides a preparation method of the hydrogel for treating female cervical erosion, which is implemented according to the following steps:
S1, weighing raw material components according to the proportion that each 1000m L of hydrogel contains 15-70 g of bletilla striata polysaccharide, 50-100 g of sea buckthorn oil, 5-20 g of forsythia suspensa oil, 5-20 g of angelica oil, 10-50 g of centella asiatica total glycosides, 0.2-1.5 g of preservative and 738.5-914.8 g of purified water for later use;
S2: adding the weighed bletilla striata polysaccharide and the centella asiatica total glycosides into purified water, and stirring until the bletilla striata polysaccharide and the centella asiatica total glycosides are fully dissolved to obtain a water phase;
S3: mixing oleum Hippophae, oleum forsythiae and radix Angelicae sinensis oil, adding antiseptic, and mixing to obtain oil phase;
S4: slowly adding the oil phase into the water phase, stirring or homogenizing until the oil phase is dispersed and emulsified uniformly, and subpackaging to obtain the hydrogel for treating the female cervical erosion.
The natural medicine hydrogel for treating female cervical erosion provided by the invention has the following beneficial effects:
(1) According to the invention, according to the etiological diversification characteristics and clinical medication experience of female cervical erosion, the effective parts of natural Chinese herbal medicines, namely the effective parts of bletilla polysaccharide, seabuckthorn oil, forsythia oil, angelica oil, asiatic centella total glycosides and the like are adopted for compatibility and formula, wherein the bletilla polysaccharide is a pharmacological active ingredient and is also a framework material of hydrogel, and the asiatic centella total glycosides are medicinal active ingredients and play a role in oil phase emulsification; the traditional Chinese medicine composition has the effects of removing putrefaction, promoting granulation, detoxifying, clearing damp, relieving swelling, alleviating pain, removing blood stasis and expelling pus, and has the exact effect of treating both symptoms and root causes for female cervical erosion through the ways of resisting bacteria and viruses, diminishing inflammation, alleviating pain, promoting mucous membrane repair and renewal, improving mucous membrane disease resistance, reducing cervical secretions, improving vaginal cleanliness, restoring balance of beneficial bacteria flora generated in vagina and the like.
(2) The invention takes the bletilla polysaccharide as the high polymer material and the biological adhesion material for preparing the hydrogel, thereby avoiding the defect that the residual organic solvent and monomer in the synthesized high polymer material possibly causes side effect; the asiaticoside is used for emulsifying the oil phase, so that the disadvantages of degreasing and stimulation of the mucous membrane by using a chemical synthesis emulsifier are avoided.
(3) The invention relates to a natural medicinal hydrogel for treating female cervical erosion, which has the advantages of high biological adhesiveness of a preparation, soft and comfortable paste and long-acting slow-release effect, and solves the defects that the existing physical therapy needs special instruments and professional technologies, and patients cannot treat the disease independently to reduce the compliance of the patients; solves the defects that the surgical therapy can cause petal-shaped columnar epithelial hyperplasia near the external cervical orifice and postoperative cervical canal stenosis; the defects that the drug resistance of pathogenic bacteria is caused by antibiotics, the incidence rate of adverse reaction is increased by combined medication, and the maladjustment of probiotics flora which damages the environment in the vagina is caused, so that the disease resistance of the vagina is lower and the disease is easier to occur are overcome; also overcomes the defects of the traditional Chinese medicine solid preparation that the dosage form is rough and the impurity content is higher, which can generate mechanical stimulation to the vagina mucosa, and the liquid preparation has strong fluidity, short detention time in the vagina and poor curative effect.
Detailed Description
In order to make the technical solutions of the present invention better understood and enable those skilled in the art to practice the present invention, the following embodiments are further described, but the present invention is not limited to the following embodiments.
When numerical ranges are given in the examples, it is understood that both endpoints of each of the numerical ranges and any value therebetween can be selected unless the invention otherwise indicated. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In addition to the specific methods, devices, and materials used in the examples, any methods, devices, and materials similar or equivalent to those described in the examples may be used in the practice of the invention in addition to the specific methods, devices, and materials used in the examples, in keeping with the knowledge of one skilled in the art and with the description of the invention.
And (3) rhizoma bletillae polysaccharide: the bletilla striata is a water-soluble polysaccharide component extracted from a traditional Chinese medicine bletilla striata and is a main active site of the bletilla striata, the bletilla striata has the efficacies of astringing and promoting granulation, clearing heat and promoting diuresis, and reducing swelling and promoting granulation, has wide pharmacological activities of ulcer resistance, inflammation resistance, hemostasis, bacteriostasis and the like in modern research, is safe and non-toxic to a human body, forms hydrogel with good biological adhesion after being dissolved in water, and can be widely used as a medical auxiliary material, a biological material, a cosmetic auxiliary material and the like;
Sea buckthorn oil: is the main active part of the traditional Chinese medicine sea buckthorn, has the effects of relieving cough and eliminating phlegm, promoting digestion and removing stagnation, and promoting blood circulation and removing blood stasis, and has the effects of enhancing immunity, resisting ulcer, resisting inflammation, resisting allergy, resisting oxidation and the like through modern research;
And (3) forsythia oil: is the main active part of the traditional Chinese medicine forsythia, has the efficacies of clearing away heat and toxic material, relieving swelling and dissipating stagnation, and the modern research shows that the forsythia has not only broad-spectrum antibacterial and antitoxic effects but also obvious anti-inflammatory and antipyretic effects, and the antibacterial and antiviral effects of the forsythia oil are superior to the water-soluble components of the forsythia;
Angelica oil: the Chinese angelica is the main active part of the Chinese medicinal angelica, and has the effects of enriching the blood, promoting the blood circulation, relieving pain and expelling pus;
Total asiaticoside: is the main active part of the asiatic pennywort herb, the asiatic pennywort herb has the efficacies of clearing away heat and toxic material, promoting diuresis and removing jaundice, and promoting blood circulation and relieving pain, and the research of the generation shows that the asiatic pennywort herb has the functions of resisting ulcer and bacteria and promoting wound healing.
According to the research results of the pathology and the traditional Chinese medicine pharmacology of modern female cervical erosion and the clinical treatment experience, the invention selects the active site compatibility formula of five natural medicines, and prepares the natural medicine hydrogel preparation by taking bletilla polysaccharide as a high polymer material for preparing hydrogel, a biological adhesion material and asiaticoside emulsified oil phase.
Based on the principle, the invention provides hydrogel for treating female cervical erosion, which mainly comprises natural medicines, wherein the natural medicines comprise the following components in parts by weight: and (3) rhizoma bletillae polysaccharide: 1.5-7.0 parts; sea buckthorn oil: 5.0-10.0 parts; and (3) forsythia oil: 0.5-2.0 parts; angelica oil: 0.5-2.0 parts; total asiaticoside: 1.0 to 5.0 parts.
The natural medicine active part has the effects of removing putrefaction, promoting granulation, detoxifying, clearing damp, relieving swelling, alleviating pain, removing blood stasis and expelling pus in the value range of the invention, and has exact effect of treating both principal and secondary aspects of diseases of female cervical erosion through the ways of resisting bacteria and viruses, diminishing inflammation, relieving pain, promoting mucous membrane repair and renewal, improving mucous membrane disease resistance, reducing cervical secretion, improving vaginal cleanliness, restoring the balance of beneficial bacteria flora generated in vagina and the like.
Preferably, the natural medicine hydrogel for treating female cervical erosion provided by the invention comprises the following embodiments:
Example 1
A natural medicine hydrogel preparation for treating female cervical erosion comprises the main components of natural medicines, wherein the natural medicines comprise the following components in parts by weight: and (3) rhizoma bletillae polysaccharide: 15g of the total weight of the mixture; sea buckthorn oil: 50g of the total weight of the mixture; and (3) forsythia oil: 5g of the total weight of the mixture; angelica oil: 20g of the total weight of the mixture; total asiaticoside: 50 g.
The preparation method of the natural medicinal hydrogel preparation for treating female cervical erosion is implemented according to the following steps:
weighing 15g of bletilla striata polysaccharide and 50g of centella asiatica total glycosides, adding into 700m L purified water, stirring to fully dissolve to obtain water phase, weighing 50g of sea buckthorn oil, 5g of weeping forsythia oil and 20g of angelica oil, mixing uniformly, adding 0.2g of chlorhexidine acetate as preservative, mixing uniformly to obtain oil phase;
slowly adding the obtained oil phase into the obtained water phase, stirring while adding until the oil phase is dispersed and emulsified uniformly, adding purified water until the total volume is 1000m L, stirring and mixing uniformly, and subpackaging to obtain the natural medicinal hydrogel for treating female cervical erosion.
Example 2
A natural medicine hydrogel preparation for treating female cervical erosion comprises the main components of natural medicines, wherein the natural medicines comprise the following components in parts by weight: and (3) rhizoma bletillae polysaccharide: 70g of a mixture; sea buckthorn oil: 100g of the total weight of the mixture; and (3) forsythia oil: 20g of the total weight of the mixture; angelica oil: 5g of the total weight of the mixture; total asiaticoside: 10 g.
The preparation method of the natural medicinal hydrogel preparation for treating female cervical erosion is implemented according to the following steps:
weighing 70g of bletilla striata polysaccharide and 10g of centella asiatica total glycosides, adding into 700m L purified water, stirring to fully dissolve to obtain water phase, weighing 100g of sea buckthorn oil, 20g of forsythia suspensa oil and 5g of angelica oil, mixing uniformly, adding 1.5g of ethylparaben as preservative, and mixing uniformly to obtain oil phase;
slowly adding the obtained oil phase into the obtained water phase, stirring while adding until the oil phase is dispersed and emulsified uniformly, adding purified water until the total volume is 1000m L, stirring and mixing uniformly, and subpackaging to obtain the natural medicinal hydrogel for treating female cervical erosion.
Example 3
A natural medicine hydrogel preparation for treating female cervical erosion comprises the main components of natural medicines, wherein the natural medicines comprise the following components in parts by weight: and (3) rhizoma bletillae polysaccharide: 50g of the total weight of the mixture; sea buckthorn oil: 70g of a mixture; and (3) forsythia oil: 10g of a mixture; angelica oil: 10g of a mixture; total asiaticoside: 30 g.
The preparation method of the natural medicinal hydrogel preparation for treating female cervical erosion is implemented according to the following steps:
weighing 50g of bletilla striata polysaccharide and 30g of centella asiatica total glycosides, adding into 700m L purified water, stirring until the mixture is fully dissolved to obtain a water phase, weighing 70g of sea buckthorn oil, 10g of forsythia suspensa oil and 10g of angelica oil, uniformly mixing, adding 1.5g of preservative, wherein the preservative consists of ethylparaben and propylparaben in a mass ratio of 1: 1, and uniformly mixing to obtain an oil phase;
slowly adding the obtained oil phase into the obtained water phase, stirring while adding until the oil phase is dispersed and emulsified uniformly, adding purified water until the total volume is 1000m L, stirring and mixing uniformly, and subpackaging to obtain the natural medicinal hydrogel for treating female cervical erosion.
Example 4
A natural medicine hydrogel preparation for treating female cervical erosion comprises the main components of natural medicines, wherein the natural medicines comprise the following components in parts by weight: and (3) rhizoma bletillae polysaccharide: 30g of the total weight of the mixture; sea buckthorn oil: 60g of the total weight of the mixture; and (3) forsythia oil: 15g of the total weight of the mixture; angelica oil: 15g of the total weight of the mixture; total asiaticoside: 20 g.
The preparation method of the natural medicinal hydrogel preparation for treating female cervical erosion is implemented according to the following steps:
weighing 30g of bletilla striata polysaccharide and 20g of centella asiatica total glycosides, adding 700m L purified water, stirring until the mixture is fully dissolved to obtain a water phase, weighing 60g of sea buckthorn oil, 15g of forsythia suspensa oil and 15g of angelica oil, uniformly mixing, adding 1.5g of preservative, wherein the preservative consists of ethylparaben and butylparaben in a mass ratio of 4: 1, and uniformly mixing to obtain an oil phase;
slowly adding the obtained oil phase into the obtained water phase, homogenizing until the oil phase is dispersed and emulsified uniformly, adding purified water until the total volume is 1000m L, stirring and mixing uniformly, and subpackaging to obtain the natural medicinal hydrogel for treating female cervical erosion.
Example 5
A natural medicine hydrogel preparation for treating female cervical erosion comprises the main components of natural medicines, wherein the natural medicines comprise the following components in parts by weight: and (3) rhizoma bletillae polysaccharide: 25g of the total weight of the mixture; sea buckthorn oil: 50g of the total weight of the mixture; and (3) forsythia oil: 10g of a mixture; angelica oil: 15g of the total weight of the mixture; total asiaticoside: 15 g.
The preparation method of the natural medicinal hydrogel preparation for treating female cervical erosion is implemented according to the following steps:
weighing 25g of bletilla striata polysaccharide and 15g of centella asiatica total glycosides, adding into 700m L purified water, stirring to fully dissolve to obtain water phase, weighing 50g of oleum Hippophae, 10g of fructus forsythiae oil and 15g of radix Angelicae sinensis oil, mixing, adding 0.5g of chlorhexidine acetate as antiseptic, and mixing to obtain oil phase;
slowly adding the obtained oil phase into the obtained water phase, homogenizing until the oil phase is dispersed and emulsified uniformly, adding purified water until the total volume is 1000m L, stirring and mixing uniformly, and subpackaging to obtain the natural medicinal hydrogel for treating the female cervical erosion.
The beneficial effects of the hydrogel formulations provided in embodiments 1-5 of the present invention are further illustrated by the following clinical application results:
1. Case selection:
Counting 28 married female patients, wherein the female patients are 25-45 years old and have main clinical manifestations of pruritus vulvae discomfort, pain, increase of unclean vaginal secretion and the like, and the patients do not use antibiotic medicines within 1 month; the degree of erosion was 10 cases, 12 cases with moderate degree, and 6 cases with severe degree. All patients meet the clinical requirements and standards on cervical erosion and related diagnosis in gynecology and obstetrics, patients with serious diseases of important organs such as heart, liver and kidney and patients with neurological diseases are excluded.
2. The treatment method comprises the following steps:
The gel administration device is slowly inserted into the vaginal cavity by adopting the intravaginal administration treatment, the medicine is pushed into the vagina by pressing the push rod with fingers, and then the gel administration device is slowly withdrawn. The medicine is administered 1 time a day, 10 days are 1 treatment course, and the treatment course is 2 treatment courses.
3. The judgment standard of the curative effect is as follows:
according to the relevant standard of the clinical research guiding principle of new traditional Chinese medicine, the treatment results are divided into remarkable treatment results, namely that clinical cervical erosion sample of a patient is changed into squamous epithelial coverage after treatment, the cervical is basically healed, the inflammation disappears, the clinical symptoms are obviously relieved, improvement is achieved, the clinical symptoms and relevant physical signs of the patient are improved but not eliminated after treatment, ineffectiveness is achieved, the patient has no obvious improvement sign after medication, and even the condition of illness deterioration appears, and the total effective rate is (remarkable + improvement) ÷totalcase number multiplied by 100%.
4. The treatment results are as follows:
By taking the hydrogel preparation provided in example 1 as an example, after the hydrogel preparation is used for treatment, 25 patients have remarkable curative effect, accounting for 89.29%; the improvement is 3 cases, accounting for 10.71 percent; the total effective rate is 100%. During the treatment process, the patient shows that the product of the invention has convenient use, no foreign body sensation, comfort, no pollution to clothes and no any adverse stimulation.
Therefore, the natural medicinal hydrogel for treating female cervical erosion provided by the invention has the effects of high biological adhesiveness of the preparation, soft and comfortable ointment and long-acting slow release, and solves the defects that the existing physical therapy needs special instruments and special technology, and patients cannot treat the disease independently so as to reduce the compliance of the patients; solves the defects that the surgical therapy can cause petal-shaped columnar epithelial hyperplasia near the external cervical orifice and postoperative cervical canal stenosis; the defects that the drug resistance of pathogenic bacteria is caused by antibiotics, the incidence rate of adverse reaction is increased by combined medication, and the maladjustment of probiotics flora which damages the environment in the vagina is caused, so that the disease resistance of the vagina is lower and the disease is easier to occur are overcome; also overcomes the defects of the traditional Chinese medicine solid preparation that the dosage form is rough and the impurity content is higher, which can generate mechanical stimulation to the vagina mucosa, and the liquid preparation has strong fluidity, short detention time in the vagina and poor curative effect.
The above-mentioned embodiments are merely preferred embodiments for fully illustrating the present invention, and the scope of protection is not limited thereto. The equivalents and modifications of the present invention which may occur to those skilled in the art are within the scope of the present invention as defined by the appended claims.
Claims (5)
1. The hydrogel for treating female cervical erosion is characterized by comprising the following raw materials in parts by weight:
And (3) rhizoma bletillae polysaccharide: 1.5-7.0 parts; sea buckthorn oil: 5.0-10.0 parts; and (3) forsythia oil: 0.5-2.0 parts; angelica oil: 0.5-2.0 parts; total asiaticoside: 1.0-5.0 parts; preservative: 0.02-0.15 part; purifying water: 73.85 to 91.48 parts.
2. The hydrogel for treating female cervical erosion according to claim 1, wherein the preservative is one of chlorhexidine acetate, ethyl paraben, propyl paraben, butyl paraben or a combination thereof.
3. The hydrogel for treating female cervical erosion according to claim 2, wherein the preservative is prepared from the following raw materials in a mass ratio of 1: 1 of ethylparaben and propylparaben.
4. The hydrogel for treating female cervical erosion according to claim 2, wherein the preservative is prepared from the following components in a mass ratio of 4: 1 of ethylparaben and butylparaben.
5. The method for preparing a hydrogel for treating female cervical erosion according to claim 1, which is specifically carried out according to the following steps:
S1, weighing raw material components according to the proportion that each 1000m L of hydrogel contains 15-70 g of bletilla striata polysaccharide, 50-100 g of sea buckthorn oil, 5-20 g of forsythia suspensa oil, 5-20 g of angelica oil, 10-50 g of centella asiatica total glycosides, 0.2-1.5 g of preservative and 738.5-914.8 g of purified water for later use;
S2: adding the weighed bletilla striata polysaccharide and the centella asiatica total glycosides into purified water, and stirring until the bletilla striata polysaccharide and the centella asiatica total glycosides are fully dissolved to obtain a water phase;
S3: mixing oleum Hippophae, oleum forsythiae and radix Angelicae sinensis oil, adding antiseptic, and mixing to obtain oil phase;
S4: slowly adding the oil phase into the water phase, stirring or homogenizing until the oil phase is dispersed and emulsified uniformly, and subpackaging to obtain the hydrogel for treating the female cervical erosion.
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| CN111773259B (en) * | 2020-08-07 | 2021-08-31 | 李伟泽 | Plant liquid medicine gel preparation for repairing vaginal mucosa injury and preparation method thereof |
| CN113181341A (en) * | 2021-05-10 | 2021-07-30 | 广州天恩药业科技有限公司 | Traditional Chinese medicine gel for treating cervical erosion |
| CN115414381B (en) * | 2022-11-07 | 2023-03-28 | 西南民族大学 | Composition with scar inhibition and/or wound healing promotion effects and preparation method and application thereof |
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