CN113274467A - Gynecological antibacterial gel and preparation method thereof - Google Patents
Gynecological antibacterial gel and preparation method thereof Download PDFInfo
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- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The invention provides gynecological antibacterial gel and a preparation method thereof, wherein the gynecological antibacterial gel comprises the following components in parts by weight: 0.5-2.5 parts of carbomer, 0.23-1.5 parts of cyclodextrin, 2-8 parts of nano-silver, 1-10 parts of chitosan, 1-8 parts of radix sophorae flavescentis, 0.1-0.6 part of radix stemonae, 0.2-0.8 part of fructus cnidii, 0.1-0.4 part of golden cypress, 0.2-0.7 part of motherwort, 0-30 parts of tween-802, 0.5-1 part of citric acid, 0.7-1 part of lactic acid, 0.5-1.5 parts of menthol, 0.2-0.5 part of borneol and 60-80 parts of ultrapure water. The gel provided by the invention has more stable texture, is not easy to dilute by vaginal secretion to reduce drug effect, is combined with traditional Chinese medicine components, has the effects of clearing wound surfaces and repairing wounds to promote healing in the process of treating vaginal diseases, can maintain the stability of vaginal micro-ecological environment, and has double effects of repairing and treating.
Description
Technical Field
The invention relates to the field of gynecological medicine nursing, in particular to a gynecological antibacterial gel and a preparation method thereof.
Background
Common gynecological diseases in clinical and daily life include: bacterial vaginitis, mycotic vaginitis, trichomonas vaginitis and other gynecological inflammations, the gynecological inflammations can bring various uncomfortable symptoms to patients, such as pruritus vulvae, abnormal leucorrhea, irregular menstruation, abdominal pain and the like, the female daily life and work are inconvenient, couple life discomfort can be caused, the female birth quality is affected, if the gynecological inflammations are not treated correctly in time, other more serious pathological changes are easy to be induced along with the development of diseases, such as hysteromyoma, ovarian cyst, breast diseases, cervical cancer and the like, and the female health is more harmed. If the treatment is not performed timely, implantation development of fertilized eggs may be hindered or ovulation failure may occur, and female infertility may be caused. Pregnancy may also be adversely affected if pregnant women become infected with gynecological inflammation. Therefore, the gynecological inflammation needs to be paid attention to, and prevention and professional effective treatment are well done.
The traditional treatment method is lotion or oral medicine, which is difficult to directly act on the affected part, the common single gel product is easy to be diluted by vaginal secretion, the drug effect is reduced, the effect of the special sterilization and inflammation-diminishing product is not relieving, the vagina is too dry, the flora is unbalanced, the later recovery is not facilitated, the sterilization and treatment performance of the mild maintenance product is not strong, the germs can not be thoroughly killed, and the treatment effect is achieved.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides the gynecological antibacterial gel which combines Chinese and western medicines, is mild and strong in sterilization and can maintain and stabilize the vaginal micro-ecological environment and the preparation method thereof.
The technical scheme of the invention is as follows:
the gynecological antibacterial gel is characterized by comprising the following raw materials by weight: 0.5-2.5 parts of carbomer, 0.23-1.5 parts of cyclodextrin, 2-8 parts of nano-silver, 1-10 parts of chitosan, 1-8 parts of radix sophorae flavescentis, 0.1-0.6 part of radix stemonae, 0.2-0.8 part of fructus cnidii, 0.1-0.4 part of golden cypress, 0.2-0.7 part of motherwort, 0-30 parts of tween-802, 0.5-1 part of citric acid, 0.7-1 part of lactic acid, 0.5-1.5 parts of menthol, 0.2-0.5 part of borneol and 60-80 parts of ultrapure water.
Furthermore, the feed consists of the following raw materials in parts by weight: 1-2 parts of carbomer, 0.5-1.5 parts of cyclodextrin, 3-6 parts of nano-silver, 2-8 parts of chitosan, 1-6 parts of radix sophorae flavescentis, 0.2-0.5 part of radix stemonae, 0.3-0.7 part of fructus cnidii, 0.1-0.3 part of cortex phellodendri, 0.3-0.6 part of motherwort, 0-30 parts of tween-805, 0.7-1 part of citric acid, 0.8-1 part of lactic acid, 0.8-1.3 parts of menthol, 0.2-0.4 part of borneol and 60-80 parts of ultrapure water.
Furthermore, the feed consists of the following raw materials in parts by weight: 1-1.5 parts of carbomer, 0.7-1.3 parts of cyclodextrin, 4-5 parts of nano-silver, 3-7 parts of chitosan, 2-5 parts of radix sophorae flavescentis, 0.3-0.5 part of radix stemonae, 0.4-0.6 part of fructus cnidii, 0.1-0.25 part of golden cypress, 0.2-0.5 part of motherwort, 0-25 parts of tween-806, 0.7-0.9 part of citric acid, 0.8-1 part of lactic acid, 0.8-1.2 parts of menthol, 0.2-0.3 part of borneol and 60-80 parts of ultrapure water.
Furthermore, the feed consists of the following raw materials in parts by weight: 1.3 parts of carbomer, 1 part of cyclodextrin, 4.5 parts of nano-silver, 5 parts of chitosan, 3 parts of radix sophorae flavescentis, 0.4 part of radix stemonae, 0.5 part of fructus cnidii, 0.2 part of cortex phellodendri, 0.4 part of motherwort, 8020 parts of tween-8020, 0.8 part of citric acid, 0.9 part of lactic acid, 1 part of menthol, 0.2 part of borneol and 80 parts of ultrapure water.
A preparation method of gynecological antibacterial gel comprises the following steps:
(1) firstly, mixing and grinding radix stemonae, phellodendron amurense and motherwort into powder, sieving the powder, adding 10 times of water to soak the powder for 1 hour, then decocting the powder for 3 times, each time for 3 hours, filtering out medicine residues, and reserving decoction to obtain the first traditional Chinese medicine extract.
(2) Mixing radix Sophorae Flavescentis and fructus Cnidii, adding 10 times of ethanol, and extracting twice, each for 1.5 hr at 80 deg.C to obtain extract II.
(3) And (2) fusing carbomer with ultrapure water, standing for 24h for natural swelling to obtain carbomer gel, dissolving tween 80 in the ultrapure water, and uniformly mixing with the carbomer gel to obtain the gel matrix.
(4) And finally adding cyclodextrin, nano-silver, chitosan, the first traditional Chinese medicine extract, the second traditional Chinese medicine extract, menthol and borneol into the gel matrix, uniformly stirring, adding citric acid and lactic acid to adjust the pH value to be between 5 and 7, and uniformly stirring to obtain the gynecological antibacterial gel.
The first Chinese medicine extract in the step (1) is characterized in that the aperture of the first Chinese medicine extract is 100-200 meshes.
The second traditional Chinese medicine extract in the step (2) is characterized in that the concentration of ethanol is 75%.
The invention has the beneficial effects that:
the gel matrix is more stable, is not easy to be diluted and washed off by secretion in vagina, can slowly release effective treatment sterilizing substances, directly and permanently acts on an affected part, and plays a role in sterilizing and repairing.
The traditional Chinese medicine and the western medicine are combined, and various traditional Chinese medicine components are adopted, so that the vaginal micro-ecological environment is stably repaired while synergistic sterilization is performed, the flora is balanced, and the later repair is promoted.
Detailed Description
For a more detailed understanding of the objects and uses of the present invention, reference is made to the following specific examples.
Example 1
2 parts of carbomer, 1.5 parts of cyclodextrin, 5 parts of nano-silver, 7 parts of chitosan, 5 parts of radix sophorae flavescentis, 0.5 part of radix stemonae, 0.3 part of fructus cnidii, 0.4 part of cortex phellodendri, 0.6 part of motherwort, 0 part of tween-8010 part of citric acid, 0.5 part of lactic acid, 0.7 part of menthol, 0.3 part of borneol and 80 parts of ultrapure water.
(1) Firstly, mixing and grinding radix stemonae, phellodendron amurense and motherwort into powder, sieving the powder, adding 5 times of water for soaking for 2 hours, then decocting the powder for 2 times, and each time for 4 hours, filtering out dregs, and leaving decoction to obtain a first traditional Chinese medicine extract.
(2) Mixing radix Sophorae Flavescentis and fructus Cnidii, adding 8 times of ethanol, extracting twice, each for 2 hr at 80 deg.C to obtain extract B.
(3) And (2) fusing carbomer with ultrapure water, standing for 24h for natural swelling to obtain carbomer gel, dissolving tween 80 in the ultrapure water, and uniformly mixing with the carbomer gel to obtain the gel matrix.
(4) And finally adding cyclodextrin, nano-silver, chitosan, the first traditional Chinese medicine extract, the second traditional Chinese medicine extract, menthol and borneol into the gel matrix, uniformly stirring, adding citric acid and lactic acid to adjust the pH value to be between 5 and 7, and uniformly stirring to obtain the gynecological antibacterial gel.
The first Chinese medicine extract in the further step (1) is characterized in that the aperture of a sieve passing through the first Chinese medicine extract is 190 meshes.
The second traditional Chinese medicine extract in the step (2) is characterized in that the concentration of ethanol is 65%.
Example 2
2.5 parts of carbomer, 0.7 part of cyclodextrin, 6 parts of nano-silver, 4 parts of chitosan, 8 parts of radix sophorae flavescentis, 0.2 part of radix stemonae, 0.7 part of fructus cnidii, 0.2 part of cortex phellodendri, 0.4 part of motherwort, 8030 parts of tween-8030, 0.9 part of citric acid, 0.9 part of lactic acid, 1 part of menthol, 0.2 part of borneol and 80 parts of ultrapure water.
(1) Firstly, mixing and grinding radix stemonae, phellodendron amurense and motherwort into powder, sieving the powder, adding 8 times of water to soak the powder for 3 hours, then decocting the powder for 4 times, and 2 hours each time, filtering out medicine residues, and reserving decoction to obtain the first traditional Chinese medicine extract.
(2) Mixing radix Sophorae Flavescentis and fructus Cnidii, adding 6 times of ethanol, extracting twice, each for 3 hr at 80 deg.C to obtain extract II.
(3) And (2) fusing carbomer with ultrapure water, standing for 24h for natural swelling to obtain carbomer gel, dissolving tween 80 in the ultrapure water, and uniformly mixing with the carbomer gel to obtain the gel matrix.
(4) And finally adding cyclodextrin, nano-silver, chitosan, the first traditional Chinese medicine extract, the second traditional Chinese medicine extract, menthol and borneol into the gel matrix, uniformly stirring, adding citric acid and lactic acid to adjust the pH value to be between 5 and 7, and uniformly stirring to obtain the gynecological antibacterial gel.
The first Chinese medicine extract in the further step (1) is characterized in that the aperture of a sieve passing through the first Chinese medicine extract is 160 meshes.
The second Chinese medicine extract in the further step (2) is characterized in that the concentration of ethanol is 95%.
Example 3
1.7 parts of carbomer, 1.3 parts of cyclodextrin, 7 parts of nano-silver, 6 parts of chitosan, 7 parts of radix sophorae flavescentis, 0.6 part of radix stemonae, 0.8 part of fructus cnidii, 0.3 part of cortex phellodendri, 0.5 part of motherwort, 8025 parts of tween-80, 0.7 part of citric acid, 0.8 part of lactic acid, 1.5 parts of menthol, 0.4 part of borneol and 70 parts of ultrapure water.
(1) Firstly, mixing and grinding radix stemonae, phellodendron amurense and motherwort into powder, sieving the powder, adding 6 times of water for soaking for 5 hours, then decocting the powder for 3 times, and 2 hours each time, filtering out dregs of a decoction, and leaving the decoction to obtain a first traditional Chinese medicine extract.
(2) Mixing radix Sophorae Flavescentis and fructus Cnidii, adding 9 times of ethanol, extracting twice, each for 3 hr at 70 deg.C to obtain extract II.
(3) And (2) fusing carbomer with ultrapure water, standing for 24h for natural swelling to obtain carbomer gel, dissolving tween 80 in the ultrapure water, and uniformly mixing with the carbomer gel to obtain the gel matrix.
(4) And finally adding cyclodextrin, nano-silver, chitosan, the first traditional Chinese medicine extract, the second traditional Chinese medicine extract, menthol and borneol into the gel matrix, uniformly stirring, adding citric acid and lactic acid to adjust the pH value to be between 5 and 7, and uniformly stirring to obtain the gynecological antibacterial gel.
The first Chinese medicine extract in the further step (1) is characterized in that the aperture of a sieve with a mesh of 130 meshes is adopted.
The second traditional Chinese medicine extract in the step (2) is characterized in that the concentration of ethanol is 75%.
Example 4
1 part of carbomer, 0.5 part of cyclodextrin, 8 parts of nano-silver, 3 parts of chitosan, 4 parts of radix sophorae flavescentis, 0.3 part of radix stemonae, 0.4 part of fructus cnidii, 0.1 part of cortex phellodendri, 0.7 part of motherwort, 0.6 part of tween-8015 part of citric acid, 0.7 part of lactic acid, 0.8 part of menthol, 0.5 part of borneol and 60 parts of ultrapure water.
(1) Firstly, mixing and grinding radix stemonae, phellodendron amurense and motherwort into powder, sieving the powder, adding 3 times of water to soak the powder for 10 hours, then decocting the powder for 4 times, and 2 hours each time, filtering out medicine residues, and reserving decoction to obtain the first traditional Chinese medicine extract.
(2) Mixing radix Sophorae Flavescentis and fructus Cnidii, adding 7 times of ethanol, and extracting twice at 90 deg.C for 2 hr each time to obtain extract B.
(3) And (2) fusing carbomer with ultrapure water, standing for 24h for natural swelling to obtain carbomer gel, dissolving tween 80 in the ultrapure water, and uniformly mixing with the carbomer gel to obtain the gel matrix.
(4) And finally adding cyclodextrin, nano-silver, chitosan, the first traditional Chinese medicine extract, the second traditional Chinese medicine extract, menthol and borneol into the gel matrix, uniformly stirring, adding citric acid and lactic acid to adjust the pH value to be between 5 and 7, and uniformly stirring to obtain the gynecological antibacterial gel.
The first Chinese medicine extract in the further step (1) is characterized in that the aperture of a sieve passing through the first Chinese medicine extract is 160 meshes.
The second Chinese medicine extract in the further step (2) is characterized in that the concentration of ethanol is 95%.
Gynecological gel is prepared according to the above examples 1-4, the bacteriostatic effect of the gynecological gel is evaluated, escherichia coli, candida albicans and staphylococcus aureus strains are selected, and the results of the test on the inhibitory and killing effects of the gynecological gel of the examples 1-4 show that the bacteriostatic rate can reach more than 95%.
The gynecological gel of the examples 1-4 is prepared, 100 patients with gynecological inflammation are selected from each group clinically, the age is 28-58, the gynecological gel is characterized by simultaneously having four symptoms of pudendum pruritus, abnormal leucorrhea, red swelling and pain feeling with different degrees, the four symptoms are the most common 4 symptoms of gynecological inflammation, the patients take a double-visit after 20 days, the using effect is checked, and the healing effects of the four symptoms are respectively counted, which is shown in a table.
The effective action effective rate of the gel of the examples 1-4 on four symptoms of pudendum pruritus, abnormal leucorrhea, red swelling and pain can be calculated by counting the effective action examples according to the experimental results, see the table
What has been described above is a general principle and advantageous advantages of the present invention. The above embodiments are merely illustrative of the principles of the present invention in detail, and it should be understood by those skilled in the art that the present invention is not limited to the above embodiments, and various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the claimed invention. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (7)
1. The gynecological antibacterial gel is characterized by comprising the following raw materials by weight: 0.5-2.5 parts of carbomer, 0.23-1.5 parts of cyclodextrin, 2-8 parts of nano-silver, 1-10 parts of chitosan, 1-8 parts of radix sophorae flavescentis, 0.1-0.6 part of radix stemonae, 0.2-0.8 part of fructus cnidii, 0.1-0.4 part of golden cypress, 0.2-0.7 part of motherwort, 0-30 parts of tween-802, 0.5-1 part of citric acid, 0.7-1 part of lactic acid, 0.5-1.5 parts of menthol, 0.2-0.5 part of borneol and 60-80 parts of ultrapure water.
2. The gynecological antibacterial gel according to claim 1, which is characterized by comprising the following raw materials by weight: 1-2 parts of carbomer, 0.5-1.5 parts of cyclodextrin, 3-6 parts of nano-silver, 2-8 parts of chitosan, 1-6 parts of radix sophorae flavescentis, 0.2-0.5 part of radix stemonae, 0.3-0.7 part of fructus cnidii, 0.1-0.3 part of cortex phellodendri, 0.3-0.6 part of motherwort, 0-30 parts of tween-805, 0.7-1 part of citric acid, 0.8-1 part of lactic acid, 0.8-1.3 parts of menthol, 0.2-0.4 part of borneol and 60-80 parts of ultrapure water.
3. The gynecological antibacterial gel according to claim 1, which is characterized by comprising the following raw materials by weight: 1-1.5 parts of carbomer, 0.7-1.3 parts of cyclodextrin, 4-5 parts of nano-silver, 3-7 parts of chitosan, 2-5 parts of radix sophorae flavescentis, 0.3-0.5 part of radix stemonae, 0.4-0.6 part of fructus cnidii, 0.1-0.25 part of golden cypress, 0.2-0.5 part of motherwort, 0-25 parts of tween-806, 0.7-0.9 part of citric acid, 0.8-1 part of lactic acid, 0.8-1.2 parts of menthol, 0.2-0.3 part of borneol and 60-80 parts of ultrapure water.
4. The gynecological antibacterial gel according to claim 1, which is characterized by comprising the following raw materials by weight: 1.3 parts of carbomer, 1 part of cyclodextrin, 4.5 parts of nano-silver, 5 parts of chitosan, 3 parts of radix sophorae flavescentis, 0.4 part of radix stemonae, 0.5 part of fructus cnidii, 0.2 part of cortex phellodendri, 0.4 part of motherwort, 8020 parts of tween-8020, 0.8 part of citric acid, 0.9 part of lactic acid, 1 part of menthol, 0.2 part of borneol and 80 parts of ultrapure water.
5. A process for the preparation of a gynecological antiseptic gel as claimed in claims 1 to 4, comprising the steps of:
firstly, mixing and grinding radix stemonae, phellodendron amurense and motherwort into powder, sieving the powder, adding 10 times of water to soak the powder for 1 hour, then decocting the powder for 3 times, wherein each time lasts for 3 hours, filtering out medicine residues, and reserving decoction to obtain a first traditional Chinese medicine extract; mixing radix Sophorae Flavescentis and fructus Cnidii, adding 10 times of ethanol, and extracting twice, each for 1.5 hr at 80 deg.C to obtain extract II; fusing carbomer with ultrapure water, standing for 24h for natural swelling to obtain carbomer gel, dissolving tween 80 in ultrapure water, and uniformly mixing with carbomer gel to obtain gel matrix; and finally adding cyclodextrin, nano-silver, chitosan, the first traditional Chinese medicine extract, the second traditional Chinese medicine extract, menthol and borneol into the gel matrix, uniformly stirring, adding citric acid and lactic acid to adjust the pH value to be between 5 and 7, and uniformly stirring to obtain the gynecological antibacterial gel.
6. The first herb extract of claim 5, wherein the first herb extract has a mesh size of 100-200 meshes.
7. The second herb extract of step (2) of claim 5, wherein the concentration of ethanol is 75%.
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| CN114533558A (en) * | 2022-03-09 | 2022-05-27 | 李崴 | Preparation method of gynecological gel capable of balancing PH |
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