CN116603025A - A topical pharmaceutical composition for treating female reproductive system inflammation and infertility - Google Patents
A topical pharmaceutical composition for treating female reproductive system inflammation and infertility Download PDFInfo
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- CN116603025A CN116603025A CN202210859978.8A CN202210859978A CN116603025A CN 116603025 A CN116603025 A CN 116603025A CN 202210859978 A CN202210859978 A CN 202210859978A CN 116603025 A CN116603025 A CN 116603025A
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Abstract
The application relates to an external pharmaceutical composition for treating female reproductive system inflammation and infertility caused by female reproductive system inflammation and a preparation method thereof, and is characterized in that the external pharmaceutical composition is an external suppository prepared from raw materials of artificial bezoar, alum, realgar, frankincense, myrrh, copperas, fructus cnidii, dragon's blood, pseudo-ginseng, borneol and Chinese date; it has the functions of clearing away heat and toxic material, eliminating dampness, killing parasite, promoting blood circulation to disperse blood clots, eliminating swelling, relieving pain, eliminating phlegm, eliminating mass, warming kidney, dispelling cold, strengthening vital qi and eliminating evil, and has obvious curative effect on various inflammations of female reproductive system and resulting infertility.
Description
Technical Field
The application relates to a pharmaceutical composition, in particular to an external pharmaceutical composition for treating female reproductive system inflammation and infertility by taking Chinese herbal medicines as raw material medicines and a preparation method thereof.
Technical Field
Female genital system inflammation is a common gynaecological disease, including vulvitis, colpitis, cervicitis, endometritis, annexitis, pelvic inflammation, etc.; in recent years, with the rapid development of society, people's ideas are constantly changed, and sexual ideas are also influenced by the incredibility, so that the female reproductive system inflammation and the series of diseases caused by the inflammation become more open, and the diseases become more frequently seen. Female suffering from gynecological inflammation usually has symptoms such as abnormal leucorrhea, vulva and vaginal itching, and waist and abdomen falling pain. Inflammation is not treated effectively in time, and is easy to cause persistent diffusion, so that chronic cervicitis including cervical polyp, cervical mucositis, cervical hypertrophy and nanocapsule and cervical intraepithelial neoplasia are formed; the sequelae of pelvic inflammatory disease, such as endometritis, endometrium polyp, intrauterine adhesion, hysteromyoma, salpingitis, salpingo ovarian cyst and the like, is easy to cause repeated abortion, infertility and the risk of ectopic pregnancy due to diseases such as intrauterine adhesion, salpingemphraxis and the like, and secondary dysmenorrhea, irregular menstruation and dyspareunia caused by inflammation seriously affect the quality of life of females.
Inflammation of the reproductive system is a disease of great aeipathia which is harmful to the health of women, and has very complex clinical manifestations and a plurality of pathogenic factors. The existing treatment methods mainly comprise oral medicines, external medicines and physical therapies. The cervical diseases can be treated by freezing, laser, electric ironing and the like in the physical therapy, although inflammatory tissues can fall off, side effects are bleeding and water exudation, scar tissue shrinkage is easy to cause cervical stenosis and adhesion, the sperm passing rate can be influenced for a female without fertility, the conception chance is reduced, and the normal delivery is difficult, and the treatment must be carried out in a hospital. Oral administration of the drug: western medicines mainly comprise antibiotics, have large side effects after long-term use, and are ineffective for chronic inflammation; the oral traditional Chinese medicine has slow effect and insignificant effect; the external medicine can directly act on the affected part, has strong pertinence, small interference to the environment in the organism and quick effect, and belongs to non-invasive therapy. However, the existing external medicine for treating gynecological inflammation has single efficacy, narrow treatment range and unsatisfactory treatment effect although various varieties exist, and the infertility caused by the external medicine is basically a test tube infant with high recommended cost and success rate of only 40% -50%.
Disclosure of Invention
Aiming at the technical problems of the traditional Chinese and western medicines for treating female reproductive system inflammation and infertility caused by the female reproductive system inflammation, the inventor carries out years of intensive research and numerous practical experiments, and provides an external medicine composition for treating female reproductive system inflammation and infertility caused by female reproductive system inflammation and a preparation method thereof by adopting a ancestral secret recipe of nine generations from home to follow the therapeutic rules of the Chinese medicine theory and combining with the modern scientific medical method.
In order to achieve the above purpose, the application is realized by the following technical scheme:
an external pharmaceutical composition for treating female system inflammation and infertility is prepared from the following raw materials in parts by weight:
1-10 parts of artificial bezoar, 10-40 parts of dried alum, 10-30 parts of myrrh, 5-30 parts of frankincense, 5-20 parts of realgar, 3-10 parts of copperas, 2-10 parts of pseudo-ginseng, 2-5 parts of fructus cnidii, 1-2 parts of dragon's blood, 1-5 parts of borneol and 50-80 parts of Chinese date.
The preparation method comprises the following steps: removing impurities from the above raw materials, weighing, except artificial bezoar and fructus Jujubae, pulverizing processed Olibanum and Myrrha, alumen, realgar, melanteritum, fructus Cnidii, notoginseng radix, sanguis Draxonis, and Borneolum Syntheticum, grinding into 80-120 mesh fine powder, adding artificial bezoar, and mixing; boiling fructus Jujubae, cooling, peeling, removing core, and making into mashed fructus Jujubae; adding fructus Jujubae paste into the fine powder of the raw materials, mixing, making into suppository with weight of 1.5-2g, and air drying; the double-layer medical gauze is used as a garment, and a cotton thread with the length of 20 cm is reserved, so that the suppository is an external suppository for treating female reproductive system inflammation and infertility. 1 granule is used every 3-5 days after cleaning, rest for 2 days and then use the second granule, and 1 course of treatment is used together with 6 granules, and 1-3 courses of treatment can be selected according to the illness state.
Inflammation of female reproductive system belongs to the categories of "leukorrhagia", "abdominal pain of women", "dysmenorrhea", "infertility", "abdominal mass", etc. in traditional Chinese medicine. Mainly caused by damp-heat toxin, which is localized in uterus and thoroughfare and conception vessels. The residual toxin invades the uterus and the pulse, the qi and blood circulation of the thoroughfare is blocked to form stasis, and the damp, heat and stasis are mutually combined to form diseases, which affect the qi and blood functions of viscera, damage healthy qi for a long time and cause cold, heat, dampness and stasis to generate endogenous qi. The primary disease is usually complicated by damp-heat stagnation, and the long-term symptoms usually include deficiency and excess, and cold and heat. Blood stasis is the pathological core of the disease due to blood stasis caused by dampness, heat, cold and deficiency. The preparation is mainly used for clearing heat, detoxicating, promoting diuresis, promoting blood circulation, removing blood stasis, warming channel, dispelling cold, soothing liver, promoting qi circulation, warming and invigorating kidney yang, strengthening body resistance, eliminating pathogenic factors, and tonifying.
The prescription of the application is composed of 11 medicines, and the artificial bezoar is: it is bitter in property and cool in taste, fragrant in smell, and specially used for heart and liver meridians, and is a good herb for clearing heat and removing toxicity, and can be used for treating carbuncle, furuncle, breast cancer, buble in the body, phlegm nodule, running-stream, scrofula, malignant sore, etc. Alum (dried alum): it is good at astringing dampness and relieving itching, removing toxicity and killing parasites because it is sour and astringent in nature and dry in nature. It is especially indicated for damp rot or itching of sore surface. Modern pharmacological research: can realize broad-spectrum antibacterial effect, has antibacterial effect on various gram-positive cocci, gram-negative bacilli, certain anaerobic bacteria, dermatophytes and candida albicans, has obvious inhibition effect on pseudomonas aeruginosa, escherichia coli and staphylococcus aureus, and has obvious effect of resisting trichomonas vaginalis. Realgar: wen Weixin it is toxic and can dispel toxic substances, kill parasites, treat sore, eliminate dampness, eliminate phlegm and check malaria. For carbuncle, swelling and furuncle. Modern pharmacological research: the realgar has the effects of killing and inhibiting various germs, inhibiting the apoptosis of tumor cells, inhibiting the synthesis of cell DNA, enhancing the cellular immunity of organisms and other factors, and playing the role of resisting tumors, and the three medicines are all monarch medicines, so that the realgar has the effects of clearing heat, promoting diuresis, detoxifying, killing parasites, eliminating phlegm and eliminating mass. Mastic gum: wen Wei it is bitter in nature, enters heart and liver meridians, and is spicy and fragrant, and can dispel blood stasis and alleviate pain, promote blood circulation and remove carbuncles, remove putrefaction and promote tissue regeneration; not only enters the blood system, but also enters the qi system, and can promote qi stagnation in the blood system, remove blood stasis and relieve pain; it can be used for treating qi stagnation, blood stasis and pain by dispersing internal qi and blood, and by dispersing external qi and blood. Modern pharmacological research: the Olibanum has effects of relieving pain, diminishing inflammation, increasing leukocyte, and promoting wound healing. Myrrh: the main actions of myrrh are similar to Ru Xiang, and they are combined together to be the key herb for freeing viscera and channels and collaterals, but they are the key herb for activating qi-blood without consuming it, and they are the ministerial herbs for activating blood and resolving stasis, removing toxicity and swelling, removing putrefaction and promoting granulation, stopping bleeding and relieving pain. Melanteritum: it is sour and astringent in nature, good at replenishing blood, removing food retention, removing toxic substance, healing sore, drying dampness and killing parasites. It can both strengthen the effect of clearing heat, removing toxicity and drying dampness, and enrich blood and remove food retention. Fructus Cnidii: wen Wei it is bitter and enters kidney meridian. The medicine has the effects of killing parasites, relieving itching, eliminating dampness, dispelling wind, supporting yang, dispelling cold, warming kidney and strengthening yang. Pseudo-ginseng: wen Weigan it is slightly bitter in nature, enters liver meridian and blood system, and has the actions of stopping bleeding, removing blood stasis and promoting tissue regeneration, and has the characteristics of stopping bleeding without retaining blood stasis and removing blood stasis without hurting healthy energy. Modern pharmacological research: notoginseng radix has effects of resisting platelet aggregation and thrombolysis; can promote proliferation of multifunctional hematopoietic stem cells to have hematopoietic effect; can improve humoral immunity, and has analgesic, antiinflammatory, and antiaging effects. Dragon's blood: it is sweet and salty in nature, enters liver meridian, and enters blood system to dispel stasis, stop bleeding and alleviate pain, and has the actions of healing sore and promoting tissue regeneration, so it can be indicated for chronic ulcer with unhealed sores. Modern pharmacological research: the dragon's blood has antibacterial and anti-inflammatory effects on various staphylococci and various pathogenic fungi to different extents, and the notoginseng and the dragon's blood have the effects of promoting blood circulation to remove blood stasis, relieving swelling and relieving pain, and tonifying deficiency and strengthening, so that the melanterite, the cnidium fruit, the notoginseng and the dragon's blood are taken as adjuvant drugs. Borneol: slightly cold and bitter in nature, fragrant in nature, clear heat and induce resuscitation, promote tissue regeneration and heal wound, reduce swelling and alleviate pain, induce menstruation, and are studied in modern pharmacology: borneol has certain pain relieving and mild antiseptic effects; has inhibiting effect on staphylococcus, streptococcus, pneumococcus, colibacillus, and part of pathogenic dermatophytes. Jujube: wen Weigan, it can tonify middle-jiao, replenish qi, nourish blood and tranquilize mind, and is used for modern pharmacological research: can enhance muscle strength, increase cAMP content in white blood cells, resist allergic reaction, calm and hypnotize, inhibit cancer cell proliferation, resist mutation, relieve pain, eliminate phlegm, etc., and can be used as excipient and harmonize various medicines, so Borneolum Syntheticum and fructus Jujubae are used as guiding drugs.
Compared with the prior art, the application has the effects of clearing heat and drying dampness, removing toxicity and killing insects, promoting blood circulation and removing blood stasis, relieving swelling and pain, eliminating phlegm and eliminating mass, warming kidney and dispelling cold, strengthening vital qi and eliminating pathogenic factor, has simple preparation process and convenient use, has obvious curative effect on various inflammations of female reproductive systems and infertility caused by the inflammations, can inhibit the deterioration of tumor and pelvic inflammatory disease sequelae, and improves the immune function of organism cells. Through practice of about 200 years, the application has no count of cure cases, letters transmitted from mouth to mouth are distributed in various provinces nationwide, and no accident occurs.
Detailed Description
Example 1.
An external pharmaceutical composition for treating female reproductive system inflammation and infertility caused by female reproductive system inflammation comprises the following raw materials in parts by weight: 2 parts of artificial bezoar, 40 parts of alum, 10 parts of myrrh (processed), 10 parts of frankincense (processed), 10 parts of realgar, 10 parts of copperas, 2 parts of pseudo-ginseng, 4 parts of fructus cnidii, 1 part of dragon's blood, 1 part of borneol and 80 parts of jujube.
The preparation method comprises the following steps: removing impurities from the above raw materials, weighing, except artificial bezoar and fructus Jujubae, pulverizing processed Olibanum and Myrrha, alumen, realgar, melanteritum, fructus Cnidii, notoginseng radix, sanguis Draxonis, and Borneolum Syntheticum, grinding into 80-120 mesh fine powder, adding artificial bezoar, and mixing; boiling fructus Jujubae, cooling, peeling, removing core, and processing into mashed fructus Jujubae; adding fructus Jujubae paste into the fine powder of the raw materials, mixing, making into suppository with weight of 1.5-2g, and air drying; the double-layer medical gauze is used as a garment, and a cotton thread with the length of 20 cm is reserved, so that the suppository is an external suppository for treating female reproductive system inflammation and infertility. 1 granule is used every 3-5 days after cleaning, rest for two days, then use 2 nd granule, and use 6 granules as 1 course of treatment, and 1-3 courses of treatment can be selected according to the illness state.
Example 2.
An external pharmaceutical composition for treating female reproductive system inflammation and infertility caused by female reproductive system inflammation comprises the following raw materials in parts by weight: 10 parts of artificial bezoar, 30 parts of dried alum, 20 parts of myrrh (processed), 20 parts of realgar, 5 parts of frankincense, 5 parts of copperas, 5 parts of fructus cnidii, 2 parts of pseudo-ginseng, 2 parts of dragon's blood, 1 part of borneol and 60 parts of Chinese date.
The preparation method comprises the following steps: removing impurities from the above materials, weighing, and oven drying at 75-80deg.C. Except artificial bezoar, the processed frankincense and myrrh are crushed together with the rest of dried alum, realgar, copperas, fructus cnidii, pseudo-ginseng, dragon's blood, borneol and Chinese date (stoning and drying) to be ground into fine powder which is sieved by a sieve of 80-120 meshes, then the artificial bezoar is added, the mixture is uniformly mixed, and the mixture is produced in batch in a factory, each Chinese medicinal suppository with the weight of 1.5-2g is prepared, double-layer medical gauze is used as a coating, and cotton threads with the length of 20 cm are reserved, so that the external suppository for treating female reproductive system inflammation and infertility is obtained. 1 granule is used every 3-5 days after cleaning, rest for two days, then use 2 nd granule, and use 6 granules as 1 course of treatment, and 1-3 courses of treatment can be selected according to the illness state.
Example 3.
An external pharmaceutical composition for treating female reproductive system inflammation and infertility caused by female reproductive system inflammation is characterized by being prepared from the following raw materials in parts by weight: 1 part of artificial bezoar, 20 parts of dried alum, 20 parts of myrrh (prepared), 20 parts of frankincense (prepared), 5 parts of realgar, 4 parts of copperas, 3 parts of fructus cnidii, 10 parts of pseudo-ginseng, 2 parts of dragon's blood, 5 parts of borneol and 54 parts of jujube.
The preparation method comprises the following steps: the raw materials are respectively removed of impurities and weighed according to the weight proportion, and the jujube is easy to glycerin. Pulverizing processed Olibanum and Myrrha, alumen, realgar, melanteritum, fructus Cnidii, notoginseng radix, sanguis Draxonis, and Borneolum Syntheticum except artificial calculus bovis and glycerol, grinding into 100-120 mesh fine powder, adding artificial calculus bovis, and mixing to obtain powder.
Mixing the above medicinal powder with glycerol (appropriate amount) to obtain paste, i.e. ointment. Can be applied 2-3 times per day for treating vulvitis, bartholinitis, cervicitis, perianal abscess, etc.
Example 4.
A pharmaceutical composition for treating female reproductive system inflammation and infertility caused by female reproductive system inflammation comprises the following raw materials in parts by weight: 1 part of artificial bezoar, 10 parts of dried alum, 30 parts of myrrh (prepared), 30 parts of frankincense (prepared), 15 parts of realgar, 3 parts of copperas, 4 parts of pseudo-ginseng, 2 parts of fructus cnidii, 2 parts of dragon's blood, 2 parts of borneol and 60 parts of jujube.
The preparation method comprises the following steps: the raw materials are respectively removed of impurities and weighed according to the weight ratio, 60 parts of jujube easy-to-use sesame oil and 25 parts of beeswax are additionally added. Pulverizing Olibanum and Myrrha, alumen, realgar, melanteritum, fructus Cnidii, notoginseng radix, sanguis Draxonis, and Borneolum Syntheticum except artificial calculus bovis, grinding into 100-120 mesh fine powder, adding artificial calculus bovis, and mixing to obtain powder. Boiling oleum Sesami, adding Cera flava, melting, adding above powder, and concocting into ointment. Spreading the affected part for 2 times a day. Can be used for treating large glandular cyst of vestibule, perianal abscess, and other toxic materials, and for treating rotten and unhealed diseases.
The clinical use condition and the treatment course of the external pharmaceutical composition for treating female reproductive system inflammation and infertility are as follows: in general, the suppository for treating vaginal and pelvic diseases and the powder, ointment or ointment for treating cervical, vulva and other diseases are prepared from the above materials.
When the application is used for treatment, menstrual period is avoided, the vulva is cleaned by clean warm boiled water, then the suppository is put into the deep vagina, 1 granule is used for 3-5 days, 2 nd granule is used after two days of rest, 6 granules are a treatment course, and 1-3 treatment courses can be selected according to the illness state; for example, the external and internal lesions of vulva can be applied with powder, ointment or salve for 2-3 times per day until they are cured.
The pharmaceutical compositions of the above examples 1-4 with various weight ratios have good curative effects on female reproductive system inflammation and infertility caused by female reproductive system inflammation. The specific examples described herein illustrate one of the formulations of the present application, and each of the examples may be formulated as suppositories, powders, ointments, salves, and other desired formulations using the illustrated method of manufacture. The scope of the present application is not limited thereto, and any person skilled in the art, within the scope of the present application, should make equivalent substitutions and modifications according to the technical scheme and the inventive concept disclosed herein, all fall within the scope of the present application.
Clinical efficacy cases:
clinical one: women with king age 24 years Qu Yang county. 2014.4.15 first-visit complaints: infertility in wedding 2+ years, abdominal pain, soreness of waist, excessive leucorrhea in flat time, and redundancy. Oviduct radiography in the market hospital: the left side is communicated and lifted; the right side is not developed. Diagnosis is as follows: 1. annexitis; 2. the oviduct is not connected; 3. endocrine disorders. Hospitals in province and city treat multiple times of fruit, friends introduce to visit the doctor, use the external suppository in the clinical application method to treat annexitis and oviduct obstruction, and orally take the traditional Chinese medicine to regulate endocrine. After 1 course of treatment, pregnancy was confirmed for 50 days at 2014.7.16 four diagnostic times. A healthy boy was born at term 2015.
Clinical II: the king women 26 years old fixed state Dongcar is in village. Initial complaints of 2013, 6 and 11: wedding for more than two years, infertility, menstrual period of 15 years, early tides, period of 28-30 days, menstrual period of 4-5 days, premenstrual abdominal pain, dark red menstrual color, and small amount of dark purple blood clot. B ultrasonic of 4 months 15 people hospitals: the uterus is normal in size and shape and the intrauterine echo is uniform. Hydrotubation: not smooth. Diagnosis is as follows: the oviduct is open and not smooth. The above clinical application method uses two external suppositories with 6 menstrual cycles, three diagnosis in 2013, 8, 15 days: stop for 37 days, early pregnancy test paper (+), 2014 term production.
Clinical III: dong women 28 years old Shijia Xinhua district stomatologist. 2012.8.19 initial diagnosis: wedding for 3+ years, infertility. Usually, there are more leucorrhea, smell, and there is dull pain on both sides of the lower abdomen. And the remainder is omitted. The related inspection data: oviduct radiography in the 2012.5.17 day hospital: thickening the bilateral oviducts. 2012.7.24 hospital B-ultrasound: 1. the uterus is slightly smaller; 2. bioophoric polycystic state. Six hormones: the PRL is high. Diagnosis: 1. bilateral salpingitis; 2. polycystic ovary syndrome; 3. hyperlactinemia. Many hospitals are not treated effectively and friends introduce to visit the doctor. Prescription: 1. the suppository 3 is externally applied. 2. The Chinese and western medicine can be used for regulating endocrine. 2012.9.25 two diagnosis: and (3) treatment: 1. the suppository 3 is externally applied. 2. The Chinese and western medicine can be used for regulating endocrine. 2012.11.10 phone announcements: stop menstruation for more than 50 days, and B ultrasonic diagnosis is performed for 50+ days. And then tells the child to give birth.
Clinical IV: the 32 years old stone family of the female is a new garden district. 2015.8.4 initial diagnosis: complaints: the married couple is in the same house for 10 years and is not pregnant, and the compound recipe treats the uncorrupt, so that the user does not hold hopes for pregnancy. The leucorrhea is more, yellow and tasty, and the lumbar and abdominal pain is diagnosed by the province II: pelvic inflammation. Listening to friend introduction for a visit requires the use of the above suppository. Taking the above suppository 12 granules at a time. After several months pregnancy is found, the patient is not in possession of the desired infertility, and recovery is favored due to treatment of pelvic inflammation. A girl is born.
Clinical fifth: poplar women 26 years old in Jiangzhou city, east, wangzhen. 2015.3.1 initial diagnosis: wedding for more than 5 years, and infertility. The menstruation is made in the period of 40-50 days after 13 years, and the menstruation is made for 5-7 days, so that the menstruation is dark red, has blood clots and is thin; expansion of the menstrual period, easy waist soreness; usually there are more leucorrhea with white color, and the color is left. On day 10 of menstruation, people's hospitals B ultrasonic: uterus size and morphology were normal, and left ovary had a 3X 4cm cyst. Diagnosis is as follows: 1. primary infertility; 2. ovarian cyst. Prescription: 1. the external suppository 4 particles.2. The Chinese and western medicines are used for regulating endocrine by the clinical application method. After 10 capsules of the above suppository for external use, five diagnosis were made on 2015.7.8 days: stopping menstruation for 48 days, and B ultrasonic treatment in the people hospital confirms that pregnancy is not observed.
Clinical six: plum women 21 years old state yao square head. 2009.4.17 initial diagnosis: wedding for 3+ month, new marriage hit red, amenorrhea for 3 months, early pregnancy test paper (-). Leucorrhea is more marked by smell, itching of the vulva and vagina, sometimes with lower abdominal pain, and the rest is slight. Gynecological examination: the vulva (-) vagina has red wall and a large amount of bean curd residue-like secretion; gong Genggong it is a posterior cervical refractive, and is a pain (++) accessory (-). Diagnosis is as follows: 1. candida vaginalis disease; 2. endometritis; 3. secondary amenorrhea. Prescription: 1. the suppository 2 granules are used by the clinical application method. 2. The traditional Chinese medicine has the effects of soothing liver, regulating qi, nourishing yin and tonifying kidney. 2009.5.6 two-day diagnosis: menstrual flow is carried out on fifteenth day of administration, and on the fourth day of menstrual flow, the dosage is changeable, the color is dark, and the blocks exist; the external vaginal itching of abdominal pain is relieved. And (3) treatment: as above. 2009.6.10 three diagnoses: complaints: stop for 37 days, have no discomfort, early pregnancy test paper (+). No other discomfort.
Clinical seven: women are spread in twenty years after 27 years old. 2010.5.7 complaints: one pregnancy is three months after wedding, natural abortion is carried out in gestation 2+ months, and after pregnancy preparation, pregnancy is carried out for more than two years, and no pregnancy is carried out. In time, the lower abdomen is relieved and painful, the leucorrhea is more, the texture is thick and white, the menstrual cycle is still accurate, the menstruation is 4-5 days old, the menstruation color is dark, blood clots are present, the menstruation is relieved and the abdominal distension is relieved, and the rest is left. Diagnosis is as follows: 1. pelvic inflammation; 2. secondary infertility. Prescription: 4 external suppositories are used by the clinical application method. 2010.6.4 two diagnosis: after the medicine is taken, the lower abdominal distention and pain are relieved. The treatment is the same as that of the previous month. 2010.7.7, stop for 35 days, early pregnancy test paper (+), no discomfort.
Clinical eight: women were kept in Yuhua area at 27 years old. 2009.6.10 initial diagnosis: complaints: secondary infertility. One birth is given after wedding, two birth is prepared at present, and three years of infertility are prepared. The leucorrhea is large, yellow in color and odorous, accompanied by blood streaks for half a year. Plain menstruation is irregular, abundant in quantity, dark red in color, thick in texture, abdominal pain during menstruation, easy to cause lumbago and slight. And (3) gynecological examination: cervical hypertrophy, cervical erosion, with a large amount of yellow secretions attached, bleeding (+). Diagnosis is as follows: 1 cervical hypertrophy; 2. cervicitis; 3. secondary infertility. Prescription: 1. the suppository 3 granules are used by the clinical application method. 2. The Chinese and western medicines regulate menstrual cycle and promote ovulation. 2009.7.8 two-day diagnosis: gynecological examination: the cervix turns pink and the secretions become clean. Continuing with the above suppository treatment, 9 granules of the above suppository for external use were followed by four diagnosis at 2010.1.16: stop menstruation for 42 days, early pregnancy test paper (+). The year of the year is informed of a girl.
Clinical nine: warm women 30 years old secure future cities. 2010.2.19 initial diagnosis: complaints: the leucorrhea is more, the color is yellow, the blood silk is present, the waist and abdomen fall pain is present, and the drip bleeding is present after the sexual life. And (3) gynecological examination: cervicitis is 2 degrees, has a large amount of yellow secretion, and cervical orifice has a peanut big polyp, and is red and soft. Diagnosis is as follows: 1. cervicitis; 2. cervical polyps. Prescription: the suppository 4 granules are used by the clinical application method. 2010.3.18 two diagnosis: the leucorrhea is reduced, the pain caused by waist and abdomen falling is reduced, and the first pill falls down to the brown tissue with the jujube-like size along with the medicine when the first pill is taken out. Gynecological examination: gong Gengwei red and cervical polyps disappear. The medicine has obvious effect, and the external suppository 4 granules are used for strengthening the curative effect, so that symptoms disappear.
Clinical ten: a woman 40 years old is fixed to a new village in North. 2018.7.3 initial diagnosis: complaints: the pregnant women are carelessly pregnant for 48 days before half a year, the induced abortion is not more bleeding after operation, and the future menstruation, leucorrhea are more, yellow and tasty, and the waist soreness and abdominal pain are easy to occur for 3 months. Diagnosis is as follows: 1. endometritis; 2. secondary amenorrhea. And (3) treatment: the suppository 4 granules are used by the clinical application method. 2018.8.11 review: when 2-3 pieces of the external suppository are used, large black tissues are discharged, the fourth piece of the external suppository is used for later menstruation, the amount of the external suppository is multicolor red, small blood clots are present, the external suppository is used for 3-4 days, the current menstruation is 6 days, the leucorrhea is multicolor and white, the external suppository is required to be continuously used for 2 pieces, the treatment is consolidated, and the external suppository is healed after the treatment.
And (3) clinical effect statistics: the number of effective components and the number of effective components are counted to determine whether the disease is healed or not
* Treatment criteria:
and (3) healing: the gynecological disease is checked to be qualified after treatment, and infertility is pregnant after treatment;
the method is effective: the inspection index of the gynecological diseases after treatment is obviously improved;
invalidation: the treatment is unchanged before and after treatment.
Claims (5)
1. An external pharmaceutical composition for treating female reproductive system inflammation and infertility is characterized by being prepared from the following raw materials in parts by weight:
1-10 parts of artificial bezoar, 10-40 parts of dried alum, 10-30 parts of myrrh, 5-30 parts of frankincense, 5-20 parts of realgar, 3-10 parts of copperas, 2-10 parts of pseudo-ginseng, 2-5 parts of fructus cnidii, 1-2 parts of dragon's blood, 1-5 parts of borneol and 50-80 parts of jujube.
2. The method for preparing a medicament for external use according to claim 1, characterized in that it comprises the steps of:
a) Removing impurities from the raw materials according to the weight ratio and weighing;
b) Pulverizing processed Olibanum and Myrrha, alumen, realgar, melanteritum, fructus Cnidii, notoginseng radix, sanguis Draxonis, and Borneolum Syntheticum except artificial calculus bovis and fructus Jujubae, grinding into fine powder of 80-120 mesh, adding artificial calculus bovis, and mixing;
c) Boiling fructus Jujubae, cooling, peeling, removing core, and processing into mashed fructus Jujubae;
d) Adding fructus Jujubae paste into the fine powder of the raw materials, mixing, making into suppository with weight of 1.5-2g, and air drying;
e) The double-layer medical gauze is used as a coat, and cotton threads with the length of 20 cm are reserved, so that the preparation is a dosage form of the medicine for treating female reproductive system inflammation and infertility.
3. The preparation method of the external medicine according to claim 2, which is characterized by comprising the steps of removing the core of the Chinese date in the raw material medicine, drying at 75-80 ℃, grinding the Chinese date and the rest raw material medicine together into fine powder, and producing the Chinese medicine external suppository in batches according to the routine flow of a factory production line.
4. The method for preparing a medicament for external use according to claim 2, characterized in that it comprises: except for the Chinese dates, the processed frankincense, myrrh and the rest alum (dried alum), realgar, copperas, fructus cnidii, pseudo-ginseng, dragon's blood and borneol are crushed and ground into fine powder which is sieved by a sieve of 80-120 meshes, and then the fine powder is added with corresponding matrixes according to a conventional method to prepare various required preparations.
5. The external pharmaceutical preparation according to claim 4, which comprises a desired dosage form of powder, suppository, ointment, etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210859978.8A CN116603025A (en) | 2022-07-22 | 2022-07-22 | A topical pharmaceutical composition for treating female reproductive system inflammation and infertility |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210859978.8A CN116603025A (en) | 2022-07-22 | 2022-07-22 | A topical pharmaceutical composition for treating female reproductive system inflammation and infertility |
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| Publication Number | Publication Date |
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| CN116603025A true CN116603025A (en) | 2023-08-18 |
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ID=87673404
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210859978.8A Withdrawn CN116603025A (en) | 2022-07-22 | 2022-07-22 | A topical pharmaceutical composition for treating female reproductive system inflammation and infertility |
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| Country | Link |
|---|---|
| CN (1) | CN116603025A (en) |
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2022
- 2022-07-22 CN CN202210859978.8A patent/CN116603025A/en not_active Withdrawn
Non-Patent Citations (2)
| Title |
|---|
| 文琴: "中药在妇科炎症中的外用", 实用医技杂志, vol. 14, no. 30, 31 October 2007 (2007-10-31), pages 4248 * |
| 罗胜田;王艳勤;赵淑文;: "宫颈糜烂病变患者的临床治疗及疗效分析", 中国医药指南, no. 03, 30 January 2014 (2014-01-30), pages 53 - 54 * |
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