CN108853410A - A kind of Chinese drugs agentia and its preparation method and application for preventing and treating gynecological disease - Google Patents
A kind of Chinese drugs agentia and its preparation method and application for preventing and treating gynecological disease Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a kind of Chinese drugs agentias and its preparation method and application for preventing and treating gynecological disease, belong to gynaecology's technical field.The Chinese drugs agentia is prepared using Chinese medicine composition, for preventing and treating gynecological disease, institute's Chinese medicine composition is by weight, including 230-270 parts of kuh-seng, 180-220 parts of frutus cnidii, 180-220 parts of semen plantaginis, 160-180 parts of Radix Angelicae Sinensis, 160-180 parts of Rhizoma Chuanxiong, 140-160 parts of the tuber of stemona, 110-140 parts of alum, 110-140 parts of peppermint, 16-18 parts of borneol, Chinese medicine composition is prepared into after Chinese drugs agentia and is pressed into the medical medicine pad of preparation in dosage form carrier.The present invention has heat-clearing and damp-drying drug using the medical medicine pad of traditional Chinese medicine liquid preparation, and anti-bacterial, anti-itching and other effects can prevent and treat the gynecological diseases such as gynaecology's mycotic vulvitis, non-abnormality vulvitis, pruritus vulvue, eczema of vulva.
Description
Technical field
The present invention relates to gynaecology's technical field more particularly to a kind of Chinese drugs agentias and its preparation for preventing and treating gynecological disease
Methods and applications.
Background technique
At present for gynecological diseases such as gynaecology's mycotic vulvitis, non-abnormality vulvitis, pruritus vulvue, eczemas of vulva
Prevention and treatment mostly uses drug for oral administration greatly or the methods such as drug smearing, open surgery are prevented and treated.
For endo-medicine, after being digested due to drug ingedient by digestive organs, then reach in blood, to illness
Generate the effect of prevention and treatment.Drug must digest first, so effective component generates variation or is lost, and really produce to disease sites
Raw effect reduces very much.Since drug is after digestive system digestion, by intestinal absorption, solved after absorption further through liver
Poison, then by blood circulation to disease sites, so it is poor to generate control efficiency.Again due in drug ingedient in addition to there is therapeutic effect
Ingredient outside, there are also side effects, then have adverse effect on to human body.
Traditional therapy such as surface chemistry drug, laser, microwave etc., chemicals can only often treat the symptoms without effecting a permanent cure,
The state of an illness can only be alleviated, can not be eradicated, and the side effect of this treatment method is larger, the women after healing is easy to appear manlike spy
Sign：Such as grow that beard, Adam's apple are prominent, sound is thicker.After also be easy to causeing premature ovarian failure, estrogen to reduce simultaneously, the heart
Vascular event rate rises, and the adverse reactions such as obesity, hypertension, heart disease, osteoporosis easily occurs in patient.Open surgery pair
The somatic damage of patient is big, and recovery time is very long, while because of the immune and endocrine metabolic diseases of uterus property of participation, having cut off son
Palace can all bring great injury to female pathology and psychologically, postoperative generations climacteric shifts to an earlier date, endocrine disturbance etc. simultaneously
Disease is sent out, and is unfavorable for maintaining normal love life.
Therefore, it is necessary to a kind of can have control efficiency to gynecological disease and safely and effectively control methods.
Summary of the invention
In order to solve the problems in the existing technology, the present invention provides a kind of for preventing and treating the Chinese medicine medicine of gynecological disease
Agent and its preparation method and application has heat-clearing and damp-drying drug, anti-bacterial, anti-itching and other effects for preventing and treating gynecological disease.
In order to achieve the above object, the technical solution adopted by the present invention is as follows：
It is a kind of for preventing and treating the Chinese medicine composition of gynecological disease, by weight, including 230-270 parts of kuh-seng, frutus cnidii
180-220 parts, 180-220 parts of semen plantaginis, 160-180 parts of Radix Angelicae Sinensis, 160-180 parts of Rhizoma Chuanxiong, 140-160 parts of the tuber of stemona, alum 110-
140 parts, 110-140 parts of peppermint, 16-18 parts of borneol.
Further, by weight, including 240-260 parts of kuh-seng, 190-210 parts of frutus cnidii, 200 parts of semen plantaginis, when
Return 170 parts, 170 parts of Rhizoma Chuanxiong, 150 parts of the tuber of stemona, 125 parts of alum, 125 parts of peppermint, 17 parts of borneol.
Further, including 250 parts of kuh-seng, 200 parts of frutus cnidii, 200 parts of semen plantaginis, 170 parts of Radix Angelicae Sinensis, 170 parts of Rhizoma Chuanxiong, hundred
150 parts of portion, 125 parts of alum, 125 parts of peppermint, 17 parts of borneol.
A kind of preparation method prepared using Chinese medicine composition for preventing and treating the Chinese drugs agentia of gynecological disease, the method packet
Include following steps：
(1) 230-270 parts of kuh-seng, 180-220 parts of frutus cnidii, 180-220 parts of semen plantaginis, 110-140 parts of peppermint, hundred are weighed
Portion 140-160 parts, 160-180 parts of Radix Angelicae Sinensis and 160-180 parts of Rhizoma Chuanxiong plus suitable water are decocted, and first is obtained after the completion of decocting
Filtrate；
(2) the first filtrate is concentrated to give concentrate；
(3) concentrated liquid handles to obtain the 4th filtrate through alcohol precipitation；
(4) 16-18 parts of borneols are weighed to be dissolved with ethyl alcohol after pretreatment, the second filtrate is filtered to obtain；
(5) 110-140 parts of alums are weighed, add water to dissolve after pretreatment alum and preservative, rear mistake to be dissolved
Filter, obtains third filtrate；
(6) the second obtained filtrate, third filtrate are mixed with the 4th filtrate, are diluted with water stirring, obtain Chinese drugs agentia,
Wherein the content of ethyl alcohol is 15%-20% in Chinese drugs agentia.
Further, amount of water is frutus cnidii, semen plantaginis, kuh-seng, peppermint, the tuber of stemona, Radix Angelicae Sinensis when decocting in the step (1)
With 6-8 times of Rhizoma Chuanxiong total weight, and decoct 2 times, decoct 1h-3h every time, merge 2 decocting liquids after the completion of decocting for 2 times and obtain first
Filtrate.
Further, concentrate and the mass ratio of the first filtrate are 3 in the step (2):1000.
Further, alcohol precipitation uses mass fraction to dissolve concentrate for 98% ethanol solution in the step (3), is used for
Remove the heavy metal in concentrate.
Further, ethyl alcohol described in the step (4) uses dehydrated alcohol, and the mass ratio of dehydrated alcohol and borneol is
100：2, the ratio of alum and preservative and water is 1 in the step (5):1-1:2.
It is a kind of for preventing and treating the Chinese drugs agentia of gynecological disease, the Chinese drugs agentia is using preparation side described in above-mentioned any one
Method is prepared.
It is a kind of for preventing and treating the application of the Chinese drugs agentia of gynecological disease, the application includes being pressed into Chinese drugs agentia to dosage form
Medical medicine pad is prepared in carrier, for preventing and treating gynecological disease, the content of Chinese drugs agentia is 4.5ml in described every medical medicine pad.
Beneficial effect：Compared with prior art, on the one hand Chinese medicine composition of the present invention has selection kuh-seng heat-clearing dry
Wet, antipruritic desinsection is monarch drug in a prescription；It is aided with frutus cnidii expelling wind and clearing away cold, eliminating dampness is antipruritic；Semen plantaginis diuresis excreting dampness；Radix Angelicae Sinensis, Rhizoma Chuanxiong promoting blood circulation are logical
Network, menstruction regulating and pain relieving, the power that principal drug assistance is allowed to heat-clearing and damp-drying drug are stronger altogether for ministerial drug；The tuber of stemona, alum removing toxic substances desinsection, eliminating dampness are antipruritic；It is thin
Lotus dissipating wind-heat, refresh oneself are adjutant in side；Borneol inducing resuscitation of having one's ideas straightened out, tool fragrance are walked to alter, and current Zhu Jinger draws all medicines and goes directly in table
It is up and down to make；The all medicines of Chinese medicine composition of the present invention tie in, and gather heat-clearing and damp-drying drug, anti-bacterial, anti-itching and other effects altogether；
On the other hand preparation method is simple for Chinese drugs agentia of the present invention, using preparation method benefit of the present invention
The Chinese drugs agentia of preparation is pressed into the medical medicine pad of preparation in dosage form carrier by the Chinese drugs agentia prepared with the Chinese medicine composition,
The medical medicine pad directly act on and female vulva, the skin due to female vulva absorption of drugs higher than any position of body
Skin can be such that the drug long period is held in rete venosum, microcirculation net and play drug efficiency, for preventing and treating outside gynaecology's mycotic
The gynecological diseases such as negative scorching, non-abnormality vulvitis, pruritus vulvue, eczema of vulva, achieve the purpose that inner disease outer treat.
Detailed description of the invention
Fig. 1 is the preparation method of Chinese drugs agentia of the present invention；
Fig. 2 is the application of Chinese drugs agentia of the present invention.
Specific embodiment
The present invention is further elaborated with reference to the accompanying drawings and examples.
A kind of Chinese medicine composition, the Chinese medicine composition is for preventing and treating gynecological disease, by weight, including kuh-seng 230-
270 parts, 180-220 parts of frutus cnidii, 180-220 parts of semen plantaginis, 160-180 parts of Radix Angelicae Sinensis, 160-180 parts of Rhizoma Chuanxiong, tuber of stemona 140-160
Part, 110-140 parts of alum, 110-140 parts of peppermint, 16-18 parts of borneol.
Composition medication brief introduction：
Kuh-seng
Source：This product is the dry root of leguminous plant kuh-seng.
Nature and flavor and channel tropism：It is bitter, cold.Return heart, liver, stomach, large intestine, bladder meridian.
Function with cure mainly：Heat-clearing and damp-drying drug, desinsection, diuresis.For hot dysentery, hematochezia, jaundice urodialysis, leukorrhea with reddish discharge, swelling of vulva yin
Itch, eczema, wet sore, pruitus, castor；Trichomonas vaginitis is controlled outside.
Frutus cnidii
Source：This product is the dry mature fruit of umbelliferae cnidium monnieri.It is harvested when two season of summer and autumn fruit maturation, removes impurity elimination
Matter is dried.
Nature and flavor and channel tropism：Pungent, bitter, temperature is slightly poisonous.Return kidney channel.
Function with cure mainly：Warming kidney and enhancing body, dry temperature, wind-dispelling, desinsection.For impotence, palace cold, morbid leucorrhoea duye.Arthritis with fixed pain caused by dampness pain in the loins；Outside
Control eczema of vulva, married woman's pruritus vulvae, trichomonas vaginitis.
Semen plantaginis
Source：This product is the dry mature seed of plantago plant or ordinary building.
Nature and flavor and channel tropism：It is sweet, it is slightly cold.Return liver, kidney, lung, small intestinl channel.
Function with cure mainly：Reducing fever and causing diuresis, excreting dampness is treating stranguria, improving eyesight, eliminating the phlegm.For edema swelling, puckery pain of heat gonorrhea, summer heat damp diarrhea
Red eye, swell pain, disease heat cough.
Radix Angelicae Sinensis
Source：This product is the dry root of plantago plant Radix Angelicae Sinensis Angelica sinensis (olir.) Diels.
Nature and flavor and channel tropism：Sweet, acrid, warm.Return liver, the heart, the spleen channel.
Function with cure mainly：Replenishing and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation,
Necessary dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, rheumatic arthralgia, traumatic injury, ulcer sores etc..
Rhizoma Chuanxiong
Source：This product is the dry rhizome of umbrella section plant Rhizoma Chuanxiong.
Nature and flavor and channel tropism：It is pungent, warm, return liver, gallbladder, pericardium channel.
Function with cure mainly：Blood-activating and qi-promoting, wind-expelling pain-stopping, be used for irregular menstruation, amenorrhoea promoting menstruation, abdominal mass abdominal pain, sternal rib shouting pain,
Treating swelling and pain by traumatic injury, headache, rheumatic arthralgia.
The tuber of stemona
Source：This product is the dried root of Stemonaceae plant radix stemonae sessilifoliae, Radix stemonae japonicae or radix stemonae tuberosae.
Nature and flavor and channel tropism：It is sweet, bitter, tepor.It is distributed in lung channel.
Function with cure mainly：Moistening lung to arrest cough, desinsection are antipruritic.For odd infested disease, skin eczema, dermatitis, delousing, maggot of going out, scabies
Mite etc..
Alum
Source：This product, which is that sulfate mineral alunite is processed, refines.Primary aqueous aluminum aluminum sulfate " KAI (SO4)
2·12HO2」。
Nature and flavor and channel tropism：It is sour, puckery, it trembles with fear.Return lung, spleen, liver, large intestine channel.
Function with cure mainly：External application removing toxic substances desinsection, eliminating dampness are antipruritic.Alum is used for eczema, scabies.Alumen hygroscopic sore, hemostasis
Change corruption, pruritus vulvae band is inferior.
Peppermint
Source：This product is the dry aerial parts of Lamiaceae plant peppermint.
Nature and flavor and channel tropism：It is pungent, it is cool.Return lung, Liver Channel.
Function with cure mainly：Dispelling wind-heat, refresh oneself, promoting eruption.For anemopyretic cold, headache, aphtha, rubeola, morbilli etc..
Borneol
Source：This product be borneol section plant kapur trunk through distillation it is cooling obtained by crystallization or with trupentine camphor etc.
Through chemical synthesis.
Nature and flavor and channel tropism：It is pungent, it is bitter, it is slightly cold.Return heart, spleen, lung channel.
Function with cure mainly：Inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.For coma, faint from fear, various sores, abscess of throat, aphtha, mesh
The diseases such as disease.
Embodiment 1
On the one hand, a kind of Chinese medicine composition is provided, the Chinese medicine composition is for preventing and treating gynecological disease, by weight
Meter, including 270 parts of kuh-seng, 180 parts of frutus cnidii, 200 parts of semen plantaginis, 170 parts of Radix Angelicae Sinensis, 170 parts of Rhizoma Chuanxiong, 150 parts of the tuber of stemona, alum
125 parts, 125 parts of peppermint, 17 parts of borneol.
On the other hand, with reference to Fig. 1, a kind of Chinese medicine medicine prepared using Chinese medicine composition for preventing and treating gynecological disease is provided
The preparation method of agent, the described method comprises the following steps：
(1) 270 parts of kuh-seng, 180 parts of frutus cnidii, 220 parts of semen plantaginis, 125 parts of peppermint, 150 parts of the tuber of stemona, Radix Angelicae Sinensis 170 are weighed
Part is decocted with 170 parts of Rhizoma Chuanxiong plus suitable water, and the first filtrate is obtained after the completion of decocting；Wherein amount of water is frutus cnidii, vehicle
Preceding son, kuh-seng, peppermint, the tuber of stemona, 6 times of Radix Angelicae Sinensis and Rhizoma Chuanxiong total weight, and decoct 2 times, 1h is decocted every time, after the completion of 2 times decoct
Merge 2 decocting liquids and obtains the first filtrate.
(2) the first filtrate is concentrated to give concentrate, wherein concentrate and the mass ratio of the first filtrate are 3:1000；
(3) concentrated liquid handles to obtain the 4th filtrate through alcohol precipitation, and wherein alcohol precipitation uses mass fraction molten for 98% ethyl alcohol
Liquid dissolves concentrate, for removing the heavy metal in concentrate；
(4) 17 parts of borneols are weighed to be dissolved with dehydrated alcohol after pretreatment, the second filtrate, and dehydrated alcohol are filtered to obtain
Mass ratio with borneol is 100：2；
(5) 125 parts of alums are weighed, add water to dissolve after pretreatment alum and preservative, filters, obtains after to be dissolved
To third filtrate, wherein the volume ratio of alum and preservative and water ratio is 1:2；
(6) the second obtained filtrate, third filtrate are mixed with the 4th filtrate, are diluted with water stirring, obtain Chinese drugs agentia,
Wherein the content of ethyl alcohol is 15%-20% in Chinese drugs agentia, within the scope of the content of ethyl alcohol in Chinese drugs agentia is 15%-20%
When, stop dilution.
It is a kind of for preventing and treating the Chinese drugs agentia of gynecological disease, the Chinese drugs agentia is using preparation method system described in the present embodiment
Standby to form, Chinese materia medica preparation described in the present embodiment is volatile liquid preparation.
A kind of application of Chinese drugs agentia, the application include being pressed into Chinese drugs agentia to the medical medicine of preparation in dosage form carrier
Pad, for preventing and treating gynecological disease, the content of Chinese drugs agentia is 4.5ml in described every medical medicine pad.
It should be noted that Chinese drugs agentia is pressed in the environment of low temperature (zero degree) high pressure (3 atmospheric pressure) with reference to Fig. 2
Enter in dosage form carrier, the content of Chinese drugs agentia is 4.5ml in the tablet form carrier, and the dosage form carrier is using bamboo fibre
The Medical protective pad of material preparation is stored after being finally loaded with the dosage form carrier packing package sterilization of Chinese drugs agentia.
Embodiment 2
On the one hand, a kind of Chinese medicine composition is provided, the Chinese medicine composition is for preventing and treating gynecological disease, by weight
Meter, including 260 parts of kuh-seng, 190 parts of frutus cnidii, 200 parts of semen plantaginis, 170 parts of Radix Angelicae Sinensis, 170 parts of Rhizoma Chuanxiong, 150 parts of the tuber of stemona, alum
125 parts, 125 parts of peppermint, 17 parts of borneol.
On the other hand, with reference to Fig. 1, a kind of Chinese medicine medicine prepared using Chinese medicine composition for preventing and treating gynecological disease is provided
The preparation method of agent, the described method comprises the following steps：
(1) 260 parts of kuh-seng, 190 parts of frutus cnidii, 200 parts of semen plantaginis, 125 parts of peppermint, 150 parts of the tuber of stemona, Radix Angelicae Sinensis 170 are weighed
Part is decocted with 170 parts of Rhizoma Chuanxiong plus suitable water, and the first filtrate is obtained after the completion of decocting；Wherein amount of water is frutus cnidii, vehicle
Preceding son, kuh-seng, peppermint, the tuber of stemona, 8 times of Radix Angelicae Sinensis and Rhizoma Chuanxiong total weight, and decoct 2 times, 3h is decocted every time, after the completion of 2 times decoct
Merge 2 decocting liquids and obtains the first filtrate.
(2) the first filtrate is concentrated to give concentrate, wherein concentrate and the mass ratio of the first filtrate are 3:1000；
(3) concentrated liquid handles to obtain the 4th filtrate through alcohol precipitation, and wherein alcohol precipitation uses mass fraction molten for 98% ethyl alcohol
Liquid dissolves concentrate, for removing the heavy metal in concentrate；
(4) 17 parts of borneols are weighed to be dissolved with dehydrated alcohol after pretreatment, the second filtrate, and dehydrated alcohol are filtered to obtain
Mass ratio with borneol is 100：2；
(5) 125 parts of alums are weighed, add water to dissolve after pretreatment alum and preservative, filters, obtains after to be dissolved
To third filtrate, wherein the volume ratio of alum and preservative and water ratio is 1:1；
(6) the second obtained filtrate, third filtrate are mixed with the 4th filtrate, are diluted with water stirring, obtain Chinese drugs agentia,
Wherein the content of ethyl alcohol is 15%-20% in Chinese drugs agentia, within the scope of the content of ethyl alcohol in Chinese drugs agentia is 15%-20%
When, stop dilution.
It is a kind of for preventing and treating the Chinese drugs agentia of gynecological disease, the Chinese drugs agentia is using preparation method system described in the present embodiment
Standby to form, Chinese materia medica preparation described in the present embodiment is volatile liquid preparation.
It is a kind of for preventing and treating the application of the Chinese drugs agentia of gynecological disease with reference to Fig. 2, the application include by Chinese drugs agentia by
It is pressed into according to method described in embodiment 1 to the medical medicine pad of preparation in dosage form carrier, for preventing and treating gynecological disease, the every doctor
The content of Chinese drugs agentia is 4.5ml in medicine medicine pad.The dosage form carrier is the Medical protective pad prepared using bamboo fiber material, finally
It is stored after being loaded with the dosage form carrier packing package sterilization of Chinese drugs agentia.
Embodiment 3
A kind of Chinese medicine composition, the Chinese medicine composition is for preventing and treating gynecological disease, by weight, including kuh-seng 240
Part, 210 parts of frutus cnidii, 200 parts of semen plantaginis, 170 parts of Radix Angelicae Sinensis, 170 parts of Rhizoma Chuanxiong, 150 parts of the tuber of stemona, 125 parts of alum, 125 parts of peppermint,
17 parts of borneol.
A kind of preparation method preparing Chinese drugs agentia using Chinese medicine composition described in the present embodiment, except composition uses this reality
It applies except the example composition, preparation method is identical as preparation method described in embodiment 1 or embodiment 2, utilizes the present embodiment
The medical medicine pad of the Chinese drugs agentia preparation of the composition preparation is also identical as preparation method described in embodiment 1, herein not
It is repeated here again.
Embodiment 4
A kind of Chinese medicine composition, the Chinese medicine composition is for preventing and treating gynecological disease, by weight, including kuh-seng 230
Part, 210 parts of frutus cnidii, 220 parts of semen plantaginis, 160 parts of Radix Angelicae Sinensis, 170 parts of Rhizoma Chuanxiong, 150 parts of the tuber of stemona, 125 parts of alum, 125 parts of peppermint,
17 parts of borneol.
A kind of preparation method preparing Chinese drugs agentia using Chinese medicine composition described in the present embodiment, except composition uses this reality
It applies except the example composition, preparation method is identical as preparation method described in embodiment 1 or embodiment 2, utilizes the present embodiment
The medical medicine pad of the Chinese drugs agentia preparation of the composition preparation is also identical as preparation method described in embodiment 1, herein not
It is repeated here again.
Embodiment 5
A kind of Chinese medicine composition, the Chinese medicine composition is for preventing and treating gynecological disease, by weight, including kuh-seng 230
Part, 220 parts of frutus cnidii, 180 parts of semen plantaginis, 180 parts of Radix Angelicae Sinensis, 160 parts of Rhizoma Chuanxiong, 160 parts of the tuber of stemona, 125 parts of alum, 125 parts of peppermint,
17 parts of borneol.
A kind of preparation method preparing Chinese drugs agentia using Chinese medicine composition described in the present embodiment, except composition uses this reality
It applies except the example composition, preparation method is identical as preparation method described in embodiment 1 or embodiment 2, utilizes the present embodiment
The medical medicine pad of the Chinese drugs agentia preparation of the composition preparation is also identical as preparation method described in embodiment 1, herein not
It is repeated here again.
Embodiment 6
A kind of Chinese medicine composition, the Chinese medicine composition is for preventing and treating gynecological disease, by weight, including kuh-seng 250
Part, 200 parts of frutus cnidii, 200 parts of semen plantaginis, 170 parts of Radix Angelicae Sinensis, 180 parts of Rhizoma Chuanxiong, 140 parts of the tuber of stemona, 110 parts of alum, 140 parts of peppermint,
16 parts of borneol.
A kind of preparation method preparing Chinese drugs agentia using Chinese medicine composition described in the present embodiment, except composition uses this reality
It applies except the example composition, preparation method is identical as preparation method described in embodiment 1 or embodiment 2, utilizes the present embodiment
The medical medicine pad of the Chinese drugs agentia preparation of the composition preparation is also identical as preparation method described in embodiment 1, herein not
It is repeated here again.
Embodiment 7
A kind of Chinese medicine composition, the Chinese medicine composition is for preventing and treating gynecological disease, by weight, including kuh-seng 250
Part, 200 parts of frutus cnidii, 200 parts of semen plantaginis, 170 parts of Radix Angelicae Sinensis, 170 parts of Rhizoma Chuanxiong, 140 parts of the tuber of stemona, 140 parts of alum, 110 parts of peppermint,
18 parts of borneol.
A kind of preparation method preparing Chinese drugs agentia using Chinese medicine composition described in the present embodiment, except composition uses this reality
It applies except the example composition, preparation method is identical as preparation method described in embodiment 1 or embodiment 2, utilizes the present embodiment
The medical medicine pad of the Chinese drugs agentia preparation of the composition preparation is also identical as preparation method described in embodiment 1, herein not
It is repeated here again.
Embodiment 8
A kind of Chinese medicine composition, the Chinese medicine composition is for preventing and treating gynecological disease, by weight, including kuh-seng 250
Part, 200 parts of frutus cnidii, 200 parts of semen plantaginis, 170 parts of Radix Angelicae Sinensis, 170 parts of Rhizoma Chuanxiong, 150 parts of the tuber of stemona, 125 parts of alum, 125 parts of peppermint,
17 parts of borneol.
A kind of preparation method preparing Chinese drugs agentia using Chinese medicine composition described in the present embodiment, except composition uses this reality
It applies except the example composition, preparation method is identical as preparation method described in embodiment 1 or embodiment 2, utilizes the present embodiment
The medical medicine pad of the Chinese drugs agentia preparation of the composition preparation is also identical as preparation method described in embodiment 1, herein not
It is repeated here again.
It should be noted that preservative preferred sodium benzoate described in this specification, and sodium benzoate in above-described embodiment
Number be 5 parts.
It should be noted that the bottom of medicine medicine pad prepared by the present invention is additionally provided with release paper (such as：Viscose paper), it is described from
Type paper is adhered by adhesive in the bottom of medical medicine pad.
The usage and dosage of medical medicine pad：Medical medicine pad is affixed on patient's underpants by the release paper for throwing off the back of medical medicine pad
Center, directly acts on perineum affected part, is close to vulva and uses, a piece of daily, every holding effect 24 hours, four after menstruation first three days
It is used, 20 days as one therapeutic course, and the state of an illness can be added just before going to bed compared with severe one night using a piece of.
It should be noted that medical medicine pad of the present invention has unique drug effect to the common disease of reproductive system inside and outside women,
Many institutes are well-known, and female vulva absorption of drugs is higher than the skin at any position of body, the reason for this is that female vulva includes big yin
Lip, clitoris, perineum, orificium urethrae externum, greater vestibular gland, paraurethral gland have quick wherein containing and its branch vein blood vessel network abundant
To feel neuropile, there is the lymphatic vessel of adjoint blood vessel, microcirculation net is fine and close, and especially pelvic cavity internal jugular vein wall is thin, valve before no vein, these
Triumph anatomic characteristic is just more advantageous to the absorption of Chinese drugs agentia in medical medicine pad of the present invention, and can make the drug longer term
It is held in rete venosum, microcirculation net and plays drug efficiency, play the role of prevention and treatment, achieve the purpose that inner disease outer treat.Except this it
Outside, vagina, uterus, fallopian tubal, ovary etc. are all the nutrition and metabolism of double set vascularity organs, these organs belong to interior raw
Device is grown, the function of their sexual glandular secretions influences reproduction and secondary sex characters, of the present invention if these organs have pathological change
Medical medicine pad, which can correct, keeps their functional rehabilitations normal, symptom under menstrual disorder, leucorrhea increasing or sexual function, can be gradually
It disappears.
Medical medicine pad performance detection
In addition to this, shape organoleptic indicator test also has been carried out to the medical medicine pad of various embodiments of the present invention preparation, it is physical and chemical
Index test and microbiological indicator test, for test result as shown in table 1 to table 3, test result meets the phase of country's formulation
The standard answered, such as GB/T8939-2008, Pharmacopoeia of People's Republic of China (version in 2015) and DB61/T1001.1-
1001.5-2015。
1 character organoleptic indicator of table test
2 physical and chemical index of table, thin layer test
The test of 3 microbiological indicator of table
| Project | Test result |
| Total number of bacterial colonies (cfu/g) | ≤200 |
| Yeast and mold total plate count (cfu/g) | ≤100 |
| Pseudomonas aeruginosa, staphylococcus aureus | It is not detected |
Clinical verification
1, case selection is carried out according to case screening criteria, wherein case screening criteria is as follows：
Mycotic vulvitis 11, non-abnormality vulvitis 14, pruritus vulvue 10, eczema of vulva 9, mycotic yin
Scorching 11 of road, bacterial vaginitis 15 and trichomonas vaginitis 10 amount to 80 case patients, date age distribution
Son 16-60 years old.
2,80 cases are randomly divided into test group and control group, wherein test group 60, control group 20.Test group makes
The Medical protective pad prepared with Chinese drugs agentia of the present invention, the second board that control group uses Shandong Yimu Ladies'Goods Co., Ltd. to produce
Sanitry towel of motherwort.
3, each case is prevented and treated and (is pasted using medical protection pad of the present invention or reference substance Sanitry towel of motherwort
It is close to external genital in underpants center to use, daily 1-2 piece), continue 14 days, is paid a return visit, checked by the outpatient service to case, chemical examination,
It is for statistical analysis using statistics percentage statistical method to control efficiency, obtain the control efficiency of test group.
Evaluation method：Be divided into pudendal pruritus according to pathological conditions or pain of itching, profuse leukorrhea, leukorrhagia color be yellow, leukorrhagia gas is smelly and
Pain of lower abdomen etc. five, and scored according to the degree of symptom, each symptom by gently to being divided into 0 point, 2 points, 4 points and 6 points again,
Decibel scores and simultaneously carries out statistics total score, scores and makes comparisons respectively before prevention and treatment, in prevention and treatment and after prevention and treatment, while before comparing prevention and treatment
Guide secretion inspection and gynecologial examination as a result, making overall merit with after prevention and treatment.
Clinical evaluation standard is as follows：
Clinical recovery：Clinical symptoms completely disappear, and vaginal fluid inspection and gynecologial examination are normal.
It is effective：Compare prevention and treatment front and back Clinical scores, after prevention and treatment branch relatively prevent and treat before be substantially reduced, vaginal fluid inspection and
Gynecologial examination is obviously improved before handing over prevention and treatment, and clinical symptoms disappear substantially.
Effectively：Compare prevention and treatment front and back Clinical scores, is reduced before score value is relatively prevented and treated after prevention and treatment, vaginal fluid inspection and gynaecology
Check there is certain improvement before relatively preventing and treating, and clinical symptoms improve.
In vain：Compare prevention and treatment front and back Clinical scores, without change, vaginal fluid inspection and woman before score value is relatively prevented and treated after prevention and treatment
Section does not improve before checking relatively prevention and treatment, and clinical symptoms do not improve.
Clinical test results are as shown in table 4 to table 5：
4 symptom of table improves result summary sheet
As seen from Table 4, test group is apparently higher than control group to the improvement rate of every symptom, shows that test group has preferably
Improve the effect of symptom.
5 clinical test results summary sheet of table
| Group | Number of cases | Recovery from illness | It is effective | Effectively | In vain | Total effective rate |
| Test group | 60 | 6 | 29 | 23 | 2 | 96.7% |
| Control group | 20 | 0 | 2 | 15 | 3 | 85.0% |
It is examined through Ridit：U=3.5274P<0.01, show that test group curative effect has significant difference compared with the control group, treats
Effect is better than control group, and does not find adverse events and side effect during the test.Clinical verification by 80 cases shows
There is reliable safety and validity using the medical medicine pad of medicine medicament preparation in the present invention, be suitable for prevention and treatment gynaecology's mycotic
Vulvitis, non-abnormality vulvitis, pruritus vulvue, eczema of vulva, to the institutes such as gynecology colpitis, cervicitis, pelvic inflammatory disease, adnexitis
The symptoms such as caused pudendal pruritus, leucorrhea increasing have certain assisting in preventing and treating effect, can be improved the disease-resistant energy of female sex organ
Power meets clinical use.
It is the preferred embodiment of the present invention above, it is noted that for those skilled in the art,
Various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also considered as this hair
Bright protection scope.
Claims (10)
1. a kind of for preventing and treating the Chinese medicine composition of gynecological disease, it is characterised in that：By weight, including kuh-seng 230-270
Part, 180-220 parts of frutus cnidii, 180-220 parts of semen plantaginis, 160-180 parts of Radix Angelicae Sinensis, 160-180 parts of Rhizoma Chuanxiong, 140-160 parts of the tuber of stemona,
110-140 parts of alum, 110-140 parts of peppermint, 16-18 parts of borneol.
2. a kind of for preventing and treating the Chinese medicine composition of gynecological disease, it is characterised in that：By weight, including kuh-seng 240-260
Part, 190-210 parts of frutus cnidii, 200 parts of semen plantaginis, 170 parts of Radix Angelicae Sinensis, 170 parts of Rhizoma Chuanxiong, 150 parts of the tuber of stemona, 125 parts of alum, peppermint
125 parts, 17 parts of borneol.
3. according to claim 1 or 2 a kind of for preventing and treating the Chinese medicine composition of gynecological disease, it is characterised in that：Including
It is 250 parts of kuh-seng, 200 parts of frutus cnidii, 200 parts of semen plantaginis, 170 parts of Radix Angelicae Sinensis, 170 parts of Rhizoma Chuanxiong, 150 parts of the tuber of stemona, 125 parts of alum, thin
125 parts of lotus, 17 parts of borneol.
4. a kind of system prepared using a kind of Chinese medicine composition described in claim 1 for preventing and treating the Chinese drugs agentia of gynecological disease
Preparation Method, it is characterised in that：It the described method comprises the following steps：
(1) 230-270 parts of kuh-seng, 180-220 parts of frutus cnidii, 180-220 parts of semen plantaginis, 110-140 parts of peppermint, the tuber of stemona are weighed
140-160 parts, 160-180 parts of Radix Angelicae Sinensis and 160-180 parts of Rhizoma Chuanxiong plus suitable water are decocted, and the first filter is obtained after the completion of decocting
Liquid；
(2) the first filtrate is concentrated to give concentrate；
(3) concentrated liquid handles to obtain the 4th filtrate through alcohol precipitation；
(4) 16-18 parts of borneols are weighed to be dissolved with ethyl alcohol after pretreatment, the second filtrate is filtered to obtain；
(5) 110-140 parts of alums are weighed, add water to dissolve after pretreatment alum and preservative, filters, obtains after to be dissolved
To third filtrate；
(6) the second obtained filtrate, third filtrate are mixed with the 4th filtrate, is diluted with water stirring, obtains Chinese drugs agentia, wherein
The content of ethyl alcohol is 15%-20% in Chinese drugs agentia.
5. according to claim 4 a kind of for preventing and treating the preparation method of the Chinese drugs agentia of gynecological disease, it is characterised in that：
Amount of water is the 6-8 of frutus cnidii, semen plantaginis, kuh-seng, peppermint, the tuber of stemona, Radix Angelicae Sinensis and Rhizoma Chuanxiong total weight when decocting in the step (1)
Times, and decoct 2 times, 1h-3h is decocted every time, is merged 2 decocting liquids after the completion of 2 decoctions and is obtained the first filtrate.
6. according to claim 4 a kind of for preventing and treating the preparation method of the Chinese drugs agentia of gynecological disease, it is characterised in that：
Concentrate and the mass ratio of the first filtrate are 3 in the step (2):1000.
7. according to claim 4 a kind of for preventing and treating the preparation method of the Chinese drugs agentia of gynecological disease, it is characterised in that：
Alcohol precipitation uses mass fraction to dissolve concentrate for 98% ethanol solution in the step (3), for removing the weight in concentrate
Metal.
8. according to claim 4 a kind of for preventing and treating the preparation method of the Chinese drugs agentia of gynecological disease, it is characterised in that：
Ethyl alcohol described in the step (4) uses dehydrated alcohol, and the mass ratio of dehydrated alcohol and borneol is 100：2, the step (5)
The ratio of middle alum and preservative and water is 1:1-1:2.
9. a kind of for preventing and treating the Chinese drugs agentia of gynecological disease, it is characterised in that：The Chinese drugs agentia is using claim 4 to power
Benefit require any one of 8 described in preparation method be prepared.
10. a kind of as claimed in claim 4 for preventing and treating the application of the Chinese drugs agentia of gynecological disease, it is characterised in that：It is described
Using including being pressed into Chinese drugs agentia to medical medicine pad is prepared in dosage form carrier, for preventing and treating gynecological disease, the every medicine
The content of Chinese drugs agentia is 4.5ml in medicine pad.
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| CN201811045005.0A CN108853410B (en) | 2018-09-07 | 2018-09-07 | Traditional Chinese medicine medicament for preventing and treating gynecological diseases and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112451570A (en) * | 2020-12-17 | 2021-03-09 | 自贡市妇幼保健院 | Postpartum vulva nursing traditional Chinese medicine composition, preparation method and application |
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| CN1111984A (en) * | 1995-04-26 | 1995-11-22 | 广东医学院医药科技开发中心 | Bath lotion series with anti-inflammatory, antipruritic and antibiotic functions |
| CN101361937A (en) * | 2008-07-31 | 2009-02-11 | 西安三八妇乐健康产业有限公司 | Medicinal pad with antibiosis, itching-relieving, wind-dispelling and dampness-eliminating function |
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2018
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| CN1111984A (en) * | 1995-04-26 | 1995-11-22 | 广东医学院医药科技开发中心 | Bath lotion series with anti-inflammatory, antipruritic and antibiotic functions |
| CN101361937A (en) * | 2008-07-31 | 2009-02-11 | 西安三八妇乐健康产业有限公司 | Medicinal pad with antibiosis, itching-relieving, wind-dispelling and dampness-eliminating function |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112451570A (en) * | 2020-12-17 | 2021-03-09 | 自贡市妇幼保健院 | Postpartum vulva nursing traditional Chinese medicine composition, preparation method and application |
| CN112451570B (en) * | 2020-12-17 | 2022-04-29 | 自贡市妇幼保健院 | Postpartum vulva nursing traditional Chinese medicine composition, preparation method and application |
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