CN104367946A

CN104367946A - Traditional Chinese medicine suppository for treating chronic endometritis and preparation method thereof

Info

Publication number: CN104367946A
Application number: CN201410620655.9A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Hengbo Instrument Co Ltd
Current assignee: Qingdao Hengbo Instrument Co Ltd
Priority date: 2014-11-06
Filing date: 2014-11-06
Publication date: 2015-02-25

Abstract

The invention discloses a traditional Chinese medicine suppository for treating chronic endometritis. The traditional Chinese medicine suppository comprises the following raw materials in parts by weight: 10-20 parts of salviae miltiorrhizae, 10-20 parts of rhizoma sparganii, 10-20 parts of caulis spatholobi, 10-20 parts of motherwort, 10-20 parts of herba patriniae, 10-20 parts of sargent gloryvine, 10-20 parts of radix paeoniae rubra, 10-20 parts of curcuma zedoary, 10-20 parts of dandelion, 10-20 parts of scutellaria baicalensis, 10-20 parts of semen cuscutae, 10-20 parts of indigo naturalis, 10-20 parts of fructus cnidii, 10-20 parts of raspberry, 10-20 parts of cordate houttuynia, 10-20 parts of radix angelicae, 10-20 parts of radix sophorae flavescentis and 10-20 parts of common andrographis herb. The traditional Chinese medicine suppository has the efficacies of clearing heat and promoting dieresis, and tonifying qi and resolving stagnation; various medicines are used for clearing and nourishing in combination, treating vital energy and blood, promoting modulation of vital energy and blood and endometrial repair, and improving the immunity of the organism. The traditional Chinese medicine suppository also has the effects of inhibiting bacteria, resisting inflammation, easing pain, affecting hemorheology, playing a good role in endometritis, and relieving the paint of a patient, and simultaneously is capable of significantly increasing the recovery rate and reducing recurrence after curing.

Description

A kind of Chinese medicine suppository for the treatment of chronic endometritis and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly a kind of Chinese medicine suppository for the treatment of chronic endometritis and preparation method thereof.

Background technology

Endometrial chronic inflammation is chronic endometritis.Can be changed by acute endometritis; Also can be spread by long-term salpingitis or serious cervicitis and form; There is intrauterine device, childbirth or post-abortion the subinvolution of a small amount of Placenta remnants and Placenta Hominis facies posterior hepatis also can cause chronic endometritis; Postclimacteric women, because body inner estrogen level reduces, endometrium and vagina inner membrance all become poor, easily by the invasion and attack of antibacterial, chronic inflammatory disease occur; In addition, submucosal myoma of uterus, mucosal polyp also can cause endometrial chronic inflammatory disease.

The cardinal symptom of chronic endometritis is irregular menstruation or metrorrhagia; Lower abdominal pain or falling inflation sense; Leucorrhoea grow in quantity; Fever etc.; In addition, uterus increases, and has tenderness, and the other surrounding tissue in uterus thickens tenderness.If old people has suffered from chronic endometritis, there will be post menopausal vaginal hemorrhage again, and had leucorrhoea grow in quantity, thinned out, courageous and upright.During treatment chronic endometritis, first should see the inducement with or without causing, as retained placental, intrauterine device etc.Remove these inducements, chronic endometritis can be fully recovered very soon.Otherwise antiinflammatory simply, curative effect also can not be remarkable.The intrauterine device laid should take out, puerperal or the chronic endometritis caused by post-abortion, should make careful dilatation and curettage of uterine and remove residual degeneration placenta tissue; Endometrial polyp is had to extract; As found, Submucous myoma or endometrial cancer according to circumstances should carry out active treatment; Senile endometrium is scorching, expansible cervical orifice, flows out in order to blood or juice.

Endometritis acute stage, endometrium is congested, edema, inflammatory cell infiltration, and suppurating appears in serious symptom person.The main manifestations of acute endometritis is heating, lower abdominal pain, leucorrhoea grow in quantity, be courage and uprightness or foul smelling sometimes, and uterus is bigger sometimes, and there is tenderness in uterus.Chronic person's performance is also substantially identical, and menorrhagia, lower abdominal pain and waist sacrum also can be had attached obviously swollen.Acute endometritis can be further development of myometritis, and salpingitis and pelvic inflammatory disease, aggravate disease.

Women often can feel lower abdomen dull pain or falling inflation sense, psoas muscle portion pain, leucorrhoea grow in quantity, rare water sample, faint yellow or purulence, courage and uprightness.And can with irregular vagina bleeding or menostaxis, dysmenorrhea, amenorrhea.Uterus increase spherical in shape, soft, have tenderness, courage and uprightness, purulent secretion can be had to discharge.The omen of chronic endometritis that Here it is.About there is the chronic endometritis patient of 20% can be completely asymptomatic, but find when doing gynecologial examination by doctor.

The Etiological of endometritis:

Though one, endometrium has periodicity to strip off, its basal layer does not strip off thereupon, once basal layer has chronic inflammatory disease to get final product the functional layer of Long-term Infection inner membrance, causes chronic endometritis.

Two, long-standing adnexitis or serious cervicitis can cause chronic endometritis.

Three, intrauterine contraceptive loop can cause chronic endometritis.

Four, giving a birth or have post-abortion the healing of a small amount of Placenta remnants or Placenta Hominis attachment surface bad, is often the reason causing chronic endometritis.

Five, submucosal myoma of uterus, mucosal polyp also can cause chronic endometritis.

Six, the chronic endometritis without obvious inducement also can exist, and cause of disease castor is many from vagina and cervix uteri.

Inspection method

1, pathologic finding: analyze from pathology, has a lot of plasma cell and lymphocytic infiltration in inner membrance interstitial.Inflammation time person's fibres visible more of a specified duration blast cell and blood capillary proliferation.Senile endometrium inflammation presents blood vessel wall thickness, sclerosis, sometimes has calcification.When pathological changes is serious, there is ulcer local.During the atrophy of inner membrance body of gland, micromicro has squamous metaplasia on the surface, has large stretch of squamous epithelial cancer to cover whole cavity of uterus inwall, be called uterus ichthyosis when squamous metaplasia is extensive.Post abortum endometritis should note the whether existence such as fine hair, decidua, particularly miscarries comparatively of a specified duration, and fine hair can high degradation, even can not find fine hair, but the surrounding of blood vessel of being everlasting can find the block decidua tissue of the sheet be dispersed in.

2, diagnostic curettage: pathogenic factor can be specified and get rid of malignant change.Preoperatively should control inflammation three days, postoperative continuation gives antiinflammatory.In art, operation should be soft, because the palace wall infected is fragile, easily causes the perforation of uterus.Senile endometrium its inner membrance scorching is belittled, and more should note during scraping.Post abortum endometritis may remain embryonal tissue, carefully comprehensive scraping should check, often can play therapeutical effect simultaneously.

3, lab testing: blood and uterine secretions antibacterial culturing and drug sensitivity test can be done, can clarify a diagnosis, and for medicine for treatment reference.

4, the inspection of B ultrasonic: B ultrasonic carries out in utero state tentative diagnosis, its check result diagnoses the no endometritis of hands in conjunction with clinical symptoms and result of laboratory test.

The general great majority of doctor trained in Western medicine use antibiotic therapy, as penicillin, streptomycin, erythromycin, gentamycin etc. can improve curative effect.But one fix on physician guidance under use.Chronic endometritis is through suitably treatment, and most humans can be cured.The confidence of healing must be established, adhere to treatment; Otherwise, will give up halfway.Therapeutic modality best is at present the method adopting traditional Chinese medical science conditioning and treating.Chinese traditional treatment effectively can solve the surface symptoms of disease, can solve pathogenic basic factor thoroughly again.Patient can also be suitable as the case may be selection physiotherapy.But patient will note must not at will medication, will carry out under the guidance of expert.For physiotherapy, also limited, can not be excessive, be unfavorable for the state of an illness excessively on the contrary, damage the health of patient.

Motherland's medical science thinks that this disease is many by hollow through row vessels of the uterus in puerperal, invades uterus in affection of exogenous damp pyretic toxicity; Or spleen is suffered from a deficiency of the kidney damage, retention of water-damp in the body is heat-transformation with the passing of time; Or surfeit delicious food savoury, interior life is damp and hot, bet uterus; Or fire caused by depression of liver-QI, phlegm-fire multiple abscess uterus, cause pelvic cavity viscera inner membrance QI-blood circulation not smooth, damp pyretic toxicity, phlegm-fire blood stasis are tied mutually, suppuration, infringement pelvic tissue.Control or wrong treatment owing to losing, cause recurrent exerbation, protracted course of disease, organ-tissue adhesion, hypertrophy form abdominal mass enclosed mass.This sick simulataneous insufficiency and excessive, the wet hot phlegm stasis of blood are suffered from mutually each other, and spleen damage of suffering from a deficiency of the kidney is it, and wet hot phlegm stasis blocking is stagnant is its mark.

Endometritis is the common frequently-occurring disease of gynecological, and because it has, the course of disease is long, the feature of easily recurrence.Become one of disease of serious harm WomanHealth, for the feature of endometritis, clinical treatment mainly adopts Antiinflammatory Regimen, as oral or intravenous drip antibiotic, coordinate the measures such as vaginadouche medicine-feeding simultaneously, later stage it is found that endometritis is also secreted with body inner estrogen and reduces relevant, and the reduction of body inner estrogen level can make endometrium thinning.More easily be subject to pathogenic bacterium invasion and attack and cause inflammation; Therefore add again oral estrogen and progestogen to improve endometrium function, but clinical therapeutic efficacy still can not get larger improvement, and many researcheres are expected to solve problem by Chinese medicine.

Summary of the invention

Technical problem to be solved by this invention is, doctor trained in Western medicine uses antibiotic therapy for the general great majority of this disease, as penicillin, streptomycin, erythromycin, gentamycin etc., easily repeatedly.Therapeutic modality best is at present the method adopting traditional Chinese medical science conditioning and treating.Chinese traditional treatment effectively can solve the surface symptoms of disease, can solve pathogenic basic factor thoroughly again.Patient can also be suitable as the case may be selection physiotherapy.But the traditional Chinese medical science is particular about and is suited the remedy to the case, individual variation is obvious, will carry out under the guidance of expert.For physiotherapy, also limited, can not be excessive, be unfavorable for the state of an illness excessively on the contrary, damage the health of patient.The present invention combines clinical experience for many years on the basis of traditional medicine, adopts modern processing method meticulously to develop.The present invention to each effective ingredient scientific compatibility of raw material medicine, focus of going directly, and instant effect, side effect is little, biocidal property is strong preparation, can efficient solution except the misery of patient, reach the object of dispelling disease.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine suppository for the treatment of chronic endometritis, in Chinese medicine suppository described in it, the ratio of weight and number of various raw material can be: Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Caulis Sargentodoxae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Semen Cuscutae 10 ~ 20 parts, Indigo Naturalis 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Herba Houttuyniae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, Herba Andrographis 10 ~ 20 parts.

The Chinese medicine suppository of described treatment chronic endometritis, in Chinese medicine suppository described in it, the ratio of weight and number of various raw material can also be: Radix Salviae Miltiorrhizae 10 ~ 15 parts, Rhizoma Sparganii 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Herba Patriniae 10 ~ 15 parts, Caulis Sargentodoxae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Rhizoma Curcumae 10 ~ 15 parts, Herba Taraxaci 10 ~ 15 parts, Radix Scutellariae 10 ~ 20 parts, Semen Cuscutae 10 ~ 20 parts, Indigo Naturalis 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Herba Houttuyniae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, Herba Andrographis 10 ~ 20 parts.

The Chinese medicine suppository of described treatment chronic endometritis, in Chinese medicine suppository described in it, the ratio of weight and number of various raw material also can be: Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Caulis Sargentodoxae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Radix Scutellariae 10 ~ 15 parts, Semen Cuscutae 10 ~ 15 parts, Indigo Naturalis 10 ~ 15 parts, Fructus Cnidii 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts, Herba Houttuyniae 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 15 parts, Radix Sophorae Flavescentis 10 ~ 15 parts, Herba Andrographis 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine suppository of chronic endometritis, described in it, the preparation process of suppository comprises: by described crude drug except the Radix Angelicae Dahuricae and Indigo Naturalis, all the other soak 30 minutes to 1 hour, heated and boiled 30 ~ 40 minutes, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into paste, then the Radix Angelicae Dahuricae, Indigo Naturalis steam distillation is extracted, and obtains crystal, is mixed in ointment obtained above; Choose substrate 50 DEG C ~ 60 DEG C heating and melting, add ointment cooling and shaping obtained above and make class warhead shape suppository, ultraviolet is killed virus.

The preparation method of the Chinese medicine suppository of described treatment chronic endometritis, the substrate used of suppository described in it can be selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under DEG C condition of temperature 50 C ~ 60, adds the medicine mastic that described preparation method is obtained, and stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; Described tampon is the tampon of afterbody with cotton thread.

For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method for the treatment of the Chinese medicine suppository of chronic endometritis, and the preparation process of described suppository comprises further:

A. described crude drug is put into pulverizer grinding and sieving except the Radix Angelicae Dahuricae and Indigo Naturalis,

B. the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times;

C. the medicinal residues after above-mentioned ethanol extraction are got again, the heating and refluxing extraction that adds water 2 times;

D. Indigo Naturalis and the Radix Angelicae Dahuricae are distilled crystallization of vaporizing to obtain, add in above-mentioned two kinds of extracting solution, substrate Mixer pot sets type, and ultraviolet is killed virus.

In described step a, described crude drug can be put into except the Radix Angelicae Dahuricae and Indigo Naturalis after pulverizer is pulverized and cross 100-120 order dusting cover, the fine powder amount that enable pass crosses dusting cover is reaching 30%, collects by the raw material fine powder of dusting cover for subsequent use.

In described step b, the particulate matter be left after sieving can be put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution be merged and leaves standstill;

In described step c, the medicinal residues that above-mentioned ethanol extraction is crossed can be added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution be merged and leaves standstill.

In described steps d, Indigo Naturalis and the Radix Angelicae Dahuricae can be distilled crystallization of vaporizing to obtain, be dried to powder; Again above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.37 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, stir evenly after adding the fine powder and crystalline powder sieved, pour in substrate, 50 DEG C ~ 60 DEG C heating and melting, cooling and shaping makes class warhead shape suppository, and the proportioning of described powder Chinese patent medicine and substrate is 1: 2 ~ 1: 4; Described tampon is the tampon of afterbody with cotton thread.

The present invention adopts stype and tampon integrated technique, compensate for the deficiency of ordinary suppository, and ordinary suppository effectively can not be delivered to the depths of vagina.Due to the self purification of vagina, when there being foreign body to exist, can increase liquid secretion, got rid of by medicine external at short notice, both reduced curative effect, and extended the course for the treatment of again, increase expense pollutes underwear again.And the present invention overcomes this technical barrier, the suppository made can give full play to curative effect of medication, has safety good, the advantage that feasibility is good, and focus of going directly, reaches the object that gets rid of illness.

The present invention has clearing away heat-damp and promoting diuresis, QI invigorating repercussive effect, is used for the treatment of that lower abdominal pain, leucorrhoea grow in quantity and yellow skin matter that damp and hot retardance causes are thick, the symptom such as lumbosacral aching pain and spiritlessness and weakness; Containing the Chinese medicine such as Herba Andrographis, Herba Patriniae and Herba Houttuyniae in the present invention, Semen Cuscutae has reinforcing the kidney and controlling nocturnal emission effect, and Herba Andrographis has clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling effect, and Fructus Cnidii has that dampness removing dispels the wind, dissipate blood stasis effect; Combination is mended clearly in each taste medication of the present invention, QI and blood is ruled together, and finally reaches the object promoting QI and blood and tune, endometrium reparation and improve immunity of organisms.Research also finds, the present invention also has antibacterial, antiinflammatory, analgesia and on hemorheology impact, and these functions all can play good effect to endometritis, thus form good synergism with antibiotic; Clinically middle two medicine couplings can be controlled clinical symptoms in time, alleviate patient suffering, also can significantly improve cure rate simultaneously, reduce the recurrence after curing.

Detailed description of the invention

The treatment of endometritis, first when distinguishing cold and heat and deficiency and excess, belongs to hot true person, anxious when heat-clearing and toxic substances removing, dampness removing leukorrhagia stopping, blood-activating analgetic, in case patient's condition deeply; Belong to cold and belong to empty person, when with the method for warming the kidney to activate YANG, dispelling cold and removing dampness, blood-activating analgetic, in order to strengthening vital QI to eliminate pathogenic factors, in concrete therapy, the methods such as Orally-administered decoction, external application, acupuncture, coloclysis can be selected, according to different state of an illness fit applications, conventional method for the treatment of as.

The traditional Chinese medical science thinks that endometritis is caused by hyperactivity of toxic heat, damp and hot retardance and cold and stagnate, and the present invention just has clearing away heat-damp and promoting diuresis, QI invigorating repercussive effect, be used for the treatment of that lower abdominal pain, leucorrhoea grow in quantity and yellow skin matter that damp and hot retardance causes are thick, the symptom such as lumbosacral aching pain and spiritlessness and weakness; Containing the eight taste Chinese medicines such as Herba Andrographis, Herba Patriniae and Herba Houttuyniae in the present invention, Semen Cuscutae has reinforcing the kidney and controlling nocturnal emission effect, and Herba Andrographis has clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling effect, and Fructus Cnidii has that dampness removing dispels the wind, dissipate blood stasis effect; Combination is mended clearly in each taste medication of the present invention, QI and blood is ruled together, and finally reaches the object promoting QI and blood and tune, endometrium reparation and improve immunity of organisms.Research also finds, the present invention also has antibacterial, antiinflammatory, analgesia and on hemorheology impact, and these functions all can play good effect to endometritis, thus form good synergism with antibiotic; Clinically middle two medicine couplings can be controlled clinical symptoms in time, alleviate patient suffering, also can significantly improve cure rate simultaneously, reduce the recurrence after curing.

Object of the present invention, is exactly all undesirable for the curative effect of the medicine of pelvic inflammatory disease in gynaecopathia, takes effect slower, large to human body side effect, comparatively large to body of women harm, and easy shortcoming repeatedly, a kind of instant effect of invention production, the medicine that side effect is little, biocidal property is strong, to remove the misery of patient.The present invention inherits the medical heritage of motherland, Traditional Chinese Medicine is developed, utilize Chinese herbal medicine resource advantage all over the mountains and plains, develop the Chinese medicine preparation of a kind of specially good effect, safety, convenience, inexpensive, pure natural, in order to treat the common gynecological diseases such as the various pelvic inflammatory disease of women, frequently-occurring disease, makes up Western medicine toxic and side effects large, endangers the defects such as dark to body of women.Preparation technology of the present invention is simple, and medicine material is cheap, good effect, can reach reasonable social effect and economic interests.The present invention has effect of blood circulation promoting and blood stasis dispelling, eliminating damp-heat, and for the pelvic inflammatory disease that the stagnation of QI is pented up, the diseases such as disease sees profuse leukorrhea, hypogastralgia, are applicable to the treatment of the commonly encountered diseases such as chronic pelvic inflammatory disease, chronic adnexitis, ovarian cyst, vaginitis, Be very effective simultaneously.This medical instrument has and dissolves fast, release advantage rapidly, reaches the object of rapid relief of symptoms and treatment.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.

Radix Paeoniae Rubra bitter in the mouth, is slightly cold.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Radix Paeoniae Rubra can purify the blood a point excess-heat, and dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between is for use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, can purify the blood a point excess-heat, can control fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for blood system excess-heat, be good at promoting blood circulation to remove blood stasis.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.

Herba Patriniae nature and flavor hardship is flat, has effect of heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs.Acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain can be cured.Enter stomach, large intestine, Liver Channel.Cure mainly heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the stagnant caused breast abdomen pain of the excess-heat stasis of blood, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.

Fructus Cnidii is pungent, bitter, temperature; Slightly poisonous.Return kidney channel.Cure mainly warming the kidney to invigorate YANG, dampness, dispel the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus; Trichomonal vaginitis is gynecological external use good medicine." Bencao Jingshu " carries: Fructus Cnidii, and bitter in the mouth is put down; " not Lu " be pungent sweet nontoxic; Modern its abnormal smells from the patient in detail, when warm-dryness syndrome of must holding concurrently, sun also.Therefore swell and ache in housewife people's the moon, man's impotence pruritus due to damp pathogen, except stagnated QI, sharp joint, malignant boil." not Lu " warming the middle warmer and descending qi, makes married woman's Zifu heat, and man is cloudy strong, has made us son.Lid can dehumidify with tongue, and temperature can cold expelling, pungently can moisten kidney, sweet energy strengthening the spleen, therefore can remove all deficiency and coldness of married woman man and to wet disease of viscera connecting with this channel.Cold-damp was both removed, then disease is gone, performance Yiyang, therefore can disease, and had tonification also.

Indigo Naturalis has heat clearing away, removing heat from blood, effect of removing toxic substances, and property is sweet, flat, nontoxic, enters liver, lung, stomach warp.Heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion, for maculae caused by violent heat pathogen, heat in blood tells nosebleed, chest pain hemoptysis, aphtha, mumps, carries: except thermal detoxification according to " key medicine divides agent ", and holding concurrently can removing heat from blood." Thunder God concocts property of medicine solution " carries: " enter liver, spleen two warp.”

Herba Taraxaci is the Chinese medicine commonly used simply, and its medical value is loaded various medical book early.Its all herbal medicine, containing compositions such as taraxasterol, taraxerol, taraxacin, caffeic acid, choline, inulin.The flat sweet and slightly bitter taste of property.Can heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Compendium of Material Medica is recorded: " heat clearing away poison, relieving dyspepsia poison, disappearing, evil is swollen, tuberculosis, furuncle are swollen for Detoxicating food-poisoning, loose stagnant gas." Herba Taraxaci hides sweet flat, its property is nontoxic.When being enter stomach into liver, the key medicine of antipyretic removing heat from blood.

Herba Andrographis is herb or the leaf of acanthaceous plant Herba Andrographis (Andrographis paniculata (Burm.f.) Nees).Have another name called Chun Lianqiuliu, Herba Andrographitis, Lan Helian, Radix Gentianae, golden Rhizoma et radix valerianae, Tremella aurantialba Bandoni et Zang hook, India's grass, Herba vallisneriae Spiralis etc.Bitter in the mouth, cold in nature.GUIXIN, lung, large intestine, urinary bladder channel.There are heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.Cure mainly bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc., external can treat furuncle toxic swelling, trauma infection contamination etc." Guangxi Chinese herbal medicine ": hemostasis removing heat from blood, removing toxic substances and promoting tissue regeneration, controls lung abscess, stomatitis.

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.External is gynecological's good medicine of activating blood circulation to dissipate blood stasis.

Caulis Sargentodoxae rhizome is pharmaceutically acceptable, has dredge the meridian passage, eliminating stasis to stop pain, effect such as promoting the circulation of blood, parasite killing of regulating the flow of vital energy, and cures mainly rheumatalgia, traumatic injury, dysmenorrhea, amenorrhea, ascarid.Hardship, flat.Return large intestine, Liver Channel.Function with cure mainly: heat-clearing and toxic substances removing, invigorate blood circulation, wind-expelling pain-stopping.For abdominalgia with intestinal abscess, pathopyretic ulcer, amenorrhea, dysmenorrhea, tumbling and swelling, rheumatic arthralgia.Bacteriostasis plate method test, 25% decoct has extremely responsive bacteriostasis to staphylococcus aureus, group B streptococcus, all has high responsive bacteriostasis to escherichia coli, bacillus pyocyaneus, alpha streptococcus, micrococcus catarrhalis, Staphylococcus albus.

Fructus Rubi plant can be used as medicine, and has multi-medicament to be worth, and its fruit has the effect of kidney invigorating and YANG supporting.Raspberry seed oil belongs to unsaturated fatty acid, can promote that the severe that of prostatic secretions covers.Effect: the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight.Make treatment index with the vaginal smear of rat, rabbit and inner membrance section, Fructus Rubi seemingly has estrogen-like effects.Bacteriostasis 100% decoct flat board burrows method, has inhibitory action, also have inhibitory action to vibrio cholera to staphylococcus.The indexs such as the vaginal smear of estrogen-like effects rat, rabbit and inner membrance section show, Fructus Rubi seemingly has estrogen-like effects.

Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria.Herba Leonuri alkalescence subcutaneous injection has central inhibitory action, and MLD is 0.4-0.6g/kg.Intravenous rabbit injection leonurine 1mg/kg, visible urine volume significantly increases.Leonurine can make Sanguis Leporis seu oryctolagi suspension generation haemolysis when higher concentration.Leonurine infusion tube dilution method 1: 13-1: 10, to achorion schoenleinii, Pilus Caprae seu Ovis sample sporidiole bacteria, epidermophyton rubrum, starlike nocadia all have inhibitory action.The dull and stereotyped paper disk method of Herba Leonuri decoct, has inhibitory action to escherichia coli, dysentery bacterium.Herba Leonuri can remove silt tissue regeneration promoting, promoting blood flow to regulate menstruation, containing the various trace elements such as selenium, manganese, can antioxidation, anti-aging, and there is pretty good beneficial face beauty treatment, anti-ageing anti-old effect.

Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: bitter in the mouth is so dampness; YIN-cold is so victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.

Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping." Japan hanako materia medica ": control conjunctival congestion bulbar conjunctiva polyp, and tire patching leaks landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, goes face Shao-defect scar.

Radix Sophorae Flavescentis is bitter, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment colpitis mycotica, is often combined with Cortex Phellodendri, is the colpitic external use gynaecological good medicine for the treatment of.

Semen Cuscutae is listed in top grade in Shennong's Herbal.Its abnormal smells from the patient is pungent, sweet, flat nontoxic.Function with cure mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, and legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, urine have the diseases such as She's drop, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.Generally be listed in top grade can taking for a long time, take improving eyesight for a long time and make light of one's life by commiting suicide and prolong life.But yang deficiency hyperactivity of fire, postcoital protrusion not flaccidity and constipation due to dry stool person prohibit clothes, according to individual physique, if there is sign of getting angry, just cut out.It can cause sexual function hyperfunction." herbal classic is met former ": " Liver and kidney edema caused by disorder of QI also for Semen Cuscutae, dispelling pathogenic wind for improving eyesight.Its property and flavor of peppery and warm matter is glued, and warms up waist knee joint be as good as with the strong muscle of the Cortex Eucommiae.Its merit specially in beneficial marrow, hard muscles and bones, only spermatorrhea, stem essence of trembling with fear goes out, and drown and have She's drop, go knee joint soreness of the shank soft, old man's Liver and kidney deficiency of vital energy, lumbago knee joint is cold, close Fructus Psoraleae, the Cortex Eucommiae with it, all fascias all belong to liver also.Deficiency of vital energy gb 1, without refreshing person, helps it with Radix Ophiopogonis, and honeyed pill takes, effect.All postcoital protrusion not flaccidity, constipation due to dry stool, the red puckery person of little water not use, partially also supporing yang with its property." generally use computer office watching for a long time for city working clan, tobacco and wine are immoderate, and uncontrolled, the excessive eye of night life must less than the behavior of injury livers such as alleviating; adopt daily drinking, and energy tonify deficiency benefit vital essence, dispelling pathogenic wind for improving eyesight; nourishing the liver and kidney, plays good health-care effect.

Rhizoma Sparganii: have another name called belt leather Rhizoma Sparganii.For the tuber of sedge cyperus iria L. rhizoma scirpi Scirpusflaviatilis (Torr.) A.Gray.Above all with matter heavily fortified point, body weight, drying, remove crust, surperficial yellow-white person for good.Swollen pain, amenorrhea, postnatal blood stasis stomachache, traumatic injury, skin ulcer swell hard down to control lump in the abdomen, coagulation of QI-blood, trusted subordinate's pain, the side of body." Japan hanako materia medica ": control married woman's blood vessels uncomfortable, cardiac and abdominal pain, fall tire, and disappear stagnant blood, mends labor, and logical menstruation, controls flatulence, disappear and flutter damage blood stasis, puerperal abdonimal pain, blood fortune stagnated blood not under." Kaibao Bencao ": main old addiction lump in the abdomen caking.

Rhizoma Curcumae is pungent, bitter, temperature.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.Effect: removing blood stasis promoting the circulation of QI to relieve pain: this product effect is similar to Rhizoma Sparganii, but warm concerted effort is comparatively large, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.Long-pending eliminating stagnation: this product energy circulation of qi promoting removing food stagnancy pain relieving, for eating accumulation, breast abdominal distention is vexed has a pain.Removing blood stasis, women's amenorrhea, or the lump in the abdomen addiction block of phlegm-damp congestion condensation.Jia Suoxue: " fluffy art acrid in the mouth is strong, specializes in the blood in gas, and main removing mass disappears heavily fortified point, goes to gather addiction block, amenorrhea blood stasis, flutters report pain.Quite same with Rhizoma Sparganii function, also cross clothes." (" medicineization justice ")

Herba Houttuyniae cold nature, bitter in the mouth.Return lung meridian, bladder, large intestine channel.Heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; Inducing diuresis for treating stranguria syndrome.Cure mainly: the main lung abscess vomiting pus of pyretic stranguria; Expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria.Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies." the southern regions of the Yunnan Province book on Chinese herbal medicine ": control lung abscess cough band pus and blood, expectorant has stench, large intestine pyretic toxicity, treats hemorrhoid." detailed outline ": dispel the heat malicious carbuncle, skin ulcer hemorrhoid proctoptosis ， Duan Malaria disease, separates Nao poison." medical center bun is wanted ": row water, assaults fortified position, goes miasma, expelling summer-heat.Treat snakeworm poison, control beriberi, carbuncle of bursting, blood stasis removing blood.

The preparation process of suppository of the present invention is: get Radix Salviae Miltiorrhizae 1500g, Rhizoma Sparganii 1500g, Caulis Spatholobi 1500g, Herba Leonuri 1500g, Herba Patriniae 1500g, Caulis Sargentodoxae 1500g, Radix Paeoniae Rubra 1500g, Rhizoma Curcumae 1500g, Herba Taraxaci 1500g, Radix Scutellariae 1500g, Semen Cuscutae 1500g, Fructus Cnidii 1500g, Fructus Rubi 1500g, Herba Houttuyniae 1500g, Radix Sophorae Flavescentis 1500g, Herba Andrographis 1500g, soak 30 minutes to 1 hour, heated and boiled 30 ~ 40 minutes, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into paste, then Radix Angelicae Dahuricae 1500g, Indigo Naturalis 1500g steam distillation is extracted, and obtains crystal, is mixed in ointment obtained above; Choose substrate 50 DEG C ~ 60 DEG C heating and melting, add ointment cooling and shaping obtained above and make class warhead shape suppository, ultraviolet is killed virus.Described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under DEG C condition of temperature 50 C ~ 60, adds the medicine mastic that described preparation method is obtained, and stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; Described tampon is the tampon of afterbody with cotton thread.

The preparation process of suppository of the present invention can also be: get Radix Salviae Miltiorrhizae 1200g, Rhizoma Sparganii 1300g, Caulis Spatholobi 1200g, Herba Leonuri 1200g, Herba Patriniae 1200g, Caulis Sargentodoxae 1100g, Radix Paeoniae Rubra 1200g, Rhizoma Curcumae 1200g, Herba Taraxaci 1200g, Radix Scutellariae 1200g, Semen Cuscutae 1100g, Fructus Cnidii 1100g, Fructus Rubi 1200g, Herba Houttuyniae 1200g, Radix Sophorae Flavescentis 1200g, Herba Andrographis 1200g, by described crude drug, put into after pulverizer is pulverized and cross 100-120 order dusting cover, the fine powder amount that enable pass crosses dusting cover is reaching 30%, collects by the raw material fine powder of dusting cover for subsequent use.The particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution is merged and leaves standstill; The medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill.Indigo Naturalis 1200g and Radix Angelicae Dahuricae 1200g is distilled crystallization of vaporizing to obtain, is dried to powder; Again above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.37 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, stir evenly after adding the fine powder and crystalline powder sieved, pour in substrate, 50 DEG C ~ 60 DEG C heating and melting, cooling and shaping makes class warhead shape suppository, and the proportioning of described powder Chinese patent medicine and substrate is 1: 2 ~ 1: 4; Described tampon is the tampon of afterbody with cotton thread.

The present invention treats chronic endometritis Chinese medicine preparation, suppository made by medicament, then get substrate heating and melting, temperature 50 C ~ 60 DEG C, add medicine fine powder of the present invention, stirring in water bath is even, be mixed into the liquid of thickness, be poured in plastic shape-forming pipe, insert tampon, cooling and shaping makes similar bullet-shaped suppository.General substrate used can be: semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol, the proportioning of medicine fine powder and substrate is 1: 2 ~ 1: 4, be preferably 1: 3, or adopt poloxamer poloxamer as substrate, it has been widely used as the hydrophilic matrix of suppository, have the following advantages: softer than the dissolubility of other substrate, quick, drug loading is also higher.

The detailed directions of described suppository is as follows: by drug suppository removing cabinet of the present invention, take out stype, pull-out afterbody cotton thread, included in by stype bottom vagina, every night once, cotton thread is stayed external, and morning next day plays pull-out tampon, and continuous use 7 days is a course for the treatment of.

Toxicology test:

Test example 1: acute toxicity test of the present invention

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: suppository of the present invention.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, dissolve suppository, are made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, treatment animal dead situation.

2, maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Suppository adding distil water is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Treat 7 days continuously after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, interim treatment in 7 days, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Test example 2: acute skin irritation test report of the present invention

1, experiment purpose: detect suppository to the stimulation/corrosiveness of laboratory animal skin and intensity

2, materials and methods:

2.1. tested material: title: the present invention washes suppository (embodiment 2 method obtains)

2.2. laboratory animal: one grade of large ear white race rabbit, 10, female, body weight 2.1-2.3kg; Thered is provided by Affiliated Hospital of Qingdao University biology department Experimental Animal Center;

2.3. ten thousand methods are tested:

Its spinal column both sides, back are cut by hair in test by the healthy rabbits selecting skin intact 10 for first 24 hours, the left and right each about 4cm × 4cm of unhairing area.Get tested material 0.2ml during test to be applied on two layers of gauze of 2.5cm × 2.5cm, be applied to skin of unhairing surface, side, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.Close after 4 hours, dismantle, and go residual tested material with warm water cleaning, 1,24 and 48 hours treatment after removing tested material smear position dermoreaction, and mark.

3, experimental result: any erythema does not appear in laboratory animal skin, red and swollen, inflammation phenomenon.

4, brief summary: judge according to skin wound repair standards of grading in " disinfection technology standard " (1999), ointment of the present invention belongs to nonirritant to animal skin stimulus intensity.

Embodiment 3: vaginal mucomembranous irritant test result

1. test method:

After laboratory animal is quarantined 3 days, select 18 above-mentioned healthy rabbits, be divided into three groups at random, often organize each 6, be respectively: blank, excipient control, suppository group of the present invention (by application liquid 5 times of concentration).Be placed in excipient control group and the intravaginal of tested material treated animal with the sterilizing cotton sliver leaching of suitable size with sterile saline and tested material respectively, contact 6 hours with vaginal mucosa, after 24 hours, put to death animal.Taking-up topical vaginal tissue, treatment pathological changes situation.

2, result of the test: vaginal mucomembranous irritant test result

Embodiment 4: skin anaphylactic test result

Use suppository of the present invention, carry out inducing and exciting contact test, therapeutic test mice after 24 hours and 48 hours, all loseing skin has the phenomenon such as erythema and edema, with negative control group zero difference.Result shows, this suppository is bordering on zero, namely without skin allergic reaction to dermoreaction intensity.

Embodiment 5: long term toxicity test data

1, experimental technique

Random for Cavia porcellus part is become 4 groups, often organizes 15.In guinea pig back spinal column both sides, depilatory is evenly coated, make its scope about 40 square centimeters of losing hair or feathers.Clean depilatory, treat and often organize Cavia porcellus after 24 hours and be coated with suppository solution 0.2,0.4 of the present invention and 0.8ml respectively, respectively containing crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, the ordinary circumstance for the treatment of Cavia porcellus, experiment terminates rear execution animal and carries out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicine suppository long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.

Result of the test shows: Chinese medicine suppository experiment safety of the present invention.This medicine is 1: 150 to group B streptococcus, staphylococcus aureus, colibacillary minimal inhibitory concentration, gonococcus is 1: 150, Candida albicans is 1: 300, it is 5 minutes to the time of killing during 1: 20 dilution factor, be 10 minutes when 1: 50, being 20 minutes when 1: 100, is 40 minutes when 1: 200, is 8 hours when 1: 400.

Clinical trial:

In female reproductive system catches, endometritis is common disease.If the state of an illness can not be effectively controlled, myometrium may be affected and develop into myometritis, cause endometritis reason numerous, common causative reason has miscarriage, lays contraceptive device, menstrual phase sexual intercourse, body inner estrogen decline and intravaginal acidity reduction etc., all can bring out endometritis above.Clinical treatment endometritis often gives oral antibiotic and artificial cycle estrogen and progestogen, and coordinate vaginadouche medicine-feeding, this traditional remedies is under suspicion in recent years simultaneously.Come from above therapy and be also in the symptomatic treatment stage, thus clinical case through treatment after relapse rate high, prognosis is out of condition.

On the basis of traditional remedies, vaginal suppository is used to treat herein.Expect that patient is after treatment, effectively can control the clinical symptoms of endometritis, also can promote endometrium reparation, improve immunity of organisms, thus reach the object for the treatment of both the principal and secondary aspects of a disease.

1 data and method

1.1 treatment group clinical data my institutes in March ,-2012 in March, 2010 accept the scorching patient of 160 cases of uterines altogether for medical treatment, and it is divided into treatment group and matched group at random, often organize 80 examples.22 ~ 38 years old treatment group age, average 31.4 ± 2.2 years old, the course of disease 4 ~ 35 weeks.Average 22.3 ± 1.9 weeks; Endometrium thickness 3.2 ± 0.5mm; Irregular menses patient 68 example, accounts for sum 87.2%, and menstrual blood volume reduces patient 59 example, accounts for sum 75.6%, and abnormal vaginal bleeding patient 53 example, accounts for sum 67.9%; Leucorrhea or secretions increase patient 72 example, account for sum 92.3%, and hypogastric region pendant pain patient 64 example, accounts for sum 82.1%, and congested adhesion patient 76 example of row endoscopy of vagina endometrium, row ultrasound diagnosis shows inflammatory reaction image patient 67 example (see table 1).

1.2 25 ~ 37 years old matched group age of matched group clinical data, average 31.7 ± 1.8 years old.The course of disease 4 ~ 35 weeks, average 2O.7 ± 2.2 week; Endometrium thickness 3.6 ± 0.4mm, irregular menses patient 62 example, accounts for sum 79.5%, and menstrual blood volume reduces patient 56 example, accounts for sum 71.8%, and abnormal vaginal bleeding patient 51 example, accounts for sum 65.4%; Leucorrhea or secretions increase patient 69 example, account for sum 88.5%, decline 1 liang organize patient clinical data compare hypogastric region pendant pain patient 61 example, account for sum 78.2%, congested adhesion patient 73 example of row endoscopy of vagina endometrium, row ultrasound diagnosis shows inflammatory reaction image patient 62 example.

The oral broad ectrum antibiotic of 1.3 Therapeutic Method matched group patient and estrogen and progestogen norethindrone, coordinate vaginadouche medicine-feeding, treatment cycle 6 weeks simultaneously; Treatment group patient is using vaginal suppository, treatment cycle 6 weeks; Two groups of patient treatments terminate rear treatment endometrium thickness, menstruation etc., judge that therapeutic effect is good and bad.

1.4 Outcome measure are with reference to (therapeutic effect is divided three classes by obstetrics and gynecology >: recovery from illness and menstruation recover normal, hypogastric region pendant pain transference cure, leucorrhea or secretions increase transference cure, endoscopy of vagina endometrium congested adhesion transference cure endometrium suitably thickens.Ultrasound diagnosis inflammatory reaction picture drop-out; Effective i.e. menstruation recovery situation is better, the disappearance or not obvious of hypogastric region pendant pain, and leucorrhea or secretions reduce, and endometrium thickness suitably increases and congested adhesion symptom just takes a turn for the better; Invalid i.e. above sign is unchanged or change not obvious, and small number of patients clinical symptoms even worsens.Total effective rate=[(recovery from illness+effectively) case load/total case load] × 100%.

1.5 statistical analysis are by the data building database of all patients.Adopt SPSS 16.0 statistics software to test analysiss to all data, data representation employing x ± S mode, P < 0.05 difference has statistical significance.

2 results

2.1 analysis of clinical affect the many factors of patient outcomes.As endometrium thickness, menstruation, the congested adhesion situation of inner membrance and leucorrhea or secretions situation etc. before patient assessment, two groups of basic document contrasts, data no significant difference, two groups of patients are overall from same attribute.

2.2 therapeutic effect analyze two groups of patients after distinct methods treatment, and treatment group patient uterine inner film thickness 5.15 ± 0.62mm recovers normal patient 72 example menstrual period, and menstrual blood volume recovers normal patient 74 example, abnormal vaginal bleeding patient 7 example; Leucorrhea or secretions increase patient 8 example.Hypogastric region pendant pain patient 9 example, congested adhesion patient 6 example of endometrium, ultrasound diagnosis inflammatory reaction image patient 3 example, cure rate; More than matched group treat index and be starkly lower than treatment group, the therapeutic effect difference of two groups of row Different therapy has statistical significance (see table 1,2).

2.3 co-action for treating results are found by contrast therapy effect, and after treatment group treatment, secretions still increases patient 8 example, accounts for sum 10%, and matched group secretions increase patient 29 example, accounts for sum 36.25%; Congested adhesion 6 example of inner membrance after treatment group treatment, account for sum 7.5%, matched group 21 example, accounts for sum 26.25%; Treatment group menstruation recovers normal person and is also better than matched group.Treatment group to add after the present invention in above three with matched group significant difference, this has benefited from the present invention and can promote endometrium reparation and alleviate the congested adhesion of inner membrance, and this medicine can also improve immunity of organisms simultaneously.Strengthen human body self opposing pathogenic bacteria invasive ability, compensate for Antibiotic therapy alone deficiency in these areas, both couplings can produce good synergism and apply to clinically obviously to improve clinical symptoms and raising curative effect.

Menstruation contrast (n, %) after table 2 liang group treatment

Note: x ²=10.389, P=0.014

Table 3 liang other Outcome measure Indexes Comparison (n, %) of group

Note: x ²=10.881, P=0.012

3 discuss

In sum, coupling antibiotic of the present invention is used for the treatment of endometritis herein, satisfactory effect is obtained in clinical, by analyzing prescription of the present invention and effect, find that two medicine couplings can produce good synergism, although the two medicine mechanisms of action are different, all comparatively high inhibition effect is played to the pathogenesis of endometritis, can timely and effective control clinical symptoms, also can improve therapeutic effect and reduce relapse rate.

Specific embodiment: money, 27 years old, has artificial abortion's history before patient, leukorrhagia dysmenorrhea 2 years She.Dilatation and curettage of uterine is not thorough.Over nearly 1 year, HUANGBAI(sic) leukorrhagia is serious, and taste is smelt as of rotten fish, waist abdomen pendant pain, and before menses mistake, the dim matter of color is dense, and 10d side is clean, and through presensation perineum and abdominal part distending pain, shape, as given birth to a child, painedly to can't bear, and can must alleviate with tablet for alleviating pain.Patient has that lower abdominal pain, leucorrhoea grow in quantity and yellow skin matter are thick, the symptom such as lumbosacral aching pain and spiritlessness and weakness.Patient's red tongue, yellow and thin fur, thready and rapid pulse string.Gynecologial examination: chronic endometritis, vaginal congest, rotten in cervix uteri lower lip, thicken tenderness on the right side of adnexa, palace body normal in size, leucorrhea microscopy: erythrocyte (+), pyocyte (+++), card belongs to the heresy stagnant dai channel of a specified duration of turbid damp, stagnation of blood stasis and heat becomes leukorrhagia, control suitable dampness, heat clearing away, dampness removing.Use following formula: Radix Salviae Miltiorrhizae 12g, Rhizoma Sparganii 13g, Caulis Spatholobi 11g, Herba Leonuri 12g, Herba Patriniae 11g, Caulis Sargentodoxae 13g, Radix Paeoniae Rubra 12g, Rhizoma Curcumae 12g, Herba Taraxaci 11g, Radix Scutellariae 12g, Semen Cuscutae 13g, Indigo Naturalis 13g, Fructus Cnidii 12g, Fructus Rubi 11g, Herba Houttuyniae 12g, Radix Angelicae Dahuricae 13g, Radix Sophorae Flavescentis 12g, Herba Andrographis 11g, makes suppository.After menstrual phase, by drug suppository removing cabinet of the present invention, take out stype, pull-out afterbody cotton thread, stype is included in vagina deep, cotton thread is stayed external, and 1 every night, morning next day plays pull-out tampon, and continuous use 7 days is a course for the treatment of.Be used in conjunction 4 courses for the treatment of.4 courses for the treatment of take effect.Gradually feel that leukorrhagia reduces, color turns light, and waist abdomen pendant pain obviously alleviates, and re-uses this Chinese medicine preparation 3 convalesce course for the treatment of.

Claims

1. treat the Chinese medicine suppository of chronic endometritis for one kind, it is characterized in that, in described Chinese medicine suppository, the parts by weight of various raw material comprise: Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Caulis Sargentodoxae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Semen Cuscutae 10 ~ 20 parts, Indigo Naturalis 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Herba Houttuyniae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, Herba Andrographis 10 ~ 20 parts.

2. treat the Chinese medicine suppository of chronic endometritis according to claim 1, it is characterized in that, in described Chinese medicine suppository, the parts by weight of various raw material comprise: Radix Salviae Miltiorrhizae 10 ~ 15 parts, Rhizoma Sparganii 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Herba Patriniae 10 ~ 15 parts, Caulis Sargentodoxae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Rhizoma Curcumae 10 ~ 15 parts, Herba Taraxaci 10 ~ 15 parts, Radix Scutellariae 10 ~ 20 parts, Semen Cuscutae 10 ~ 20 parts, Indigo Naturalis 10 ~ 20 parts, Fructus Cnidii 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Herba Houttuyniae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, Herba Andrographis 10 ~ 20 parts.

3. treat the Chinese medicine suppository of chronic endometritis according to claim 1, it is characterized in that, in described Chinese medicine suppository, the parts by weight of various raw material comprise: Radix Salviae Miltiorrhizae 10 ~ 20 parts, Rhizoma Sparganii 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Caulis Sargentodoxae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Radix Scutellariae 10 ~ 15 parts, Semen Cuscutae 10 ~ 15 parts, Indigo Naturalis 10 ~ 15 parts, Fructus Cnidii 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts, Herba Houttuyniae 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 15 parts, Radix Sophorae Flavescentis 10 ~ 15 parts, Herba Andrographis 10 ~ 15 parts.

4. according to any one of claims 1 to 3, treat the preparation method of the Chinese medicine suppository of chronic endometritis for one kind, it is characterized in that, the preparation process of described suppository comprises: by described crude drug except the Radix Angelicae Dahuricae and Indigo Naturalis, all the other soak 30 minutes to 1 hour, heated and boiled 30 ~ 40 minutes, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into paste, then the Radix Angelicae Dahuricae, Indigo Naturalis steam distillation is extracted, and obtains crystal, is mixed in ointment obtained above; Choose substrate 50 DEG C ~ 60 DEG C heating and melting, add ointment cooling and shaping obtained above and make class warhead shape suppository, ultraviolet is killed virus.

5. according to any one of Claims 1 to 4, treat the preparation method of the Chinese medicine suppository of chronic endometritis, it is characterized in that, described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under DEG C condition of temperature 50 C ~ 60, adds the medicine mastic that described preparation method is obtained, and stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; Described tampon is the tampon of afterbody with cotton thread.

6. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine suppository of chronic endometritis, it is characterized in that, the preparation process of described suppository comprises further:

7. the preparation method of suppository according to claim 6, it is characterized in that, in described step a, described crude drug is put into except the Radix Angelicae Dahuricae and Indigo Naturalis after pulverizer is pulverized and cross 100-120 order dusting cover, the fine powder amount that enable pass crosses dusting cover is reaching 30%, collects by the raw material fine powder of dusting cover for subsequent use.

8. the preparation method of suppository according to claim 6, is characterized in that, in described step b, the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, is merged by 2 extracting solution and leave standstill;

9. the preparation method of suppository according to claim 6, is characterized in that, in described step c, the medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, is merged by 2 extracting solution and leaves standstill.

10. the preparation method of suppository according to claim 6, is characterized in that, in described steps d, Indigo Naturalis and the Radix Angelicae Dahuricae are distilled crystallization of vaporizing to obtain, be dried to powder; Again above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.37 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, stir evenly after adding the fine powder and crystalline powder sieved, pour in substrate, 50 DEG C ~ 60 DEG C heating and melting, cooling and shaping makes class warhead shape suppository, and the proportioning of described powder Chinese patent medicine and substrate is 1: 2 ~ 1: 4; Described tampon is the tampon of afterbody with cotton thread.