CN104338086A - Chinese medicinal enema for treating chronic endometritis and preparation method thereof - Google Patents

Chinese medicinal enema for treating chronic endometritis and preparation method thereof Download PDF

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CN104338086A
CN104338086A CN201410620608.4A CN201410620608A CN104338086A CN 104338086 A CN104338086 A CN 104338086A CN 201410620608 A CN201410620608 A CN 201410620608A CN 104338086 A CN104338086 A CN 104338086A
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herba
enema
radix
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不公告发明人
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Qingdao Hengbo Instrument Co Ltd
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
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    • A61K36/738Rosa (rose)
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a Chinese medicinal enema for treating chronic endometritis. The Chinese medicinal enema is prepared from the following raw materials in parts by weight: 10-20 parts of spreading hedyotis herb, 10-20 parts of red-rooted salvia root, 10-20 parts of suberect spatholobus stem, 10-20 parts of motherwort herb, 10-20 parts of dahurian patrinia herb, 10-20 parts of sargentg loryvine stem, 10-20 parts of red peony root, 10-20 parts of curcuma zedoary, 10-20 parts of dandelion, 10-20 parts of baikal skullcap root, 10-20 parts of cherokee rose fruit, 10-20 parts of raspberry, 10-20 parts of lightyellow sophora root, 10-20 parts of common bletilla pseudobulb, 10-20 parts of common andrographis herb, 10-20 parts of barbed skullcap herb, 10-20 parts of Chinese angelica, 10-20 parts of climbing groundsel herb, 10-20 parts of mint and 10-20 parts of densefruit pittany root-bark. The Chinese medicinal enema has the effects of clearing heat, promoting diuresis, tonifying qi and eliminating stasis, and is used for treating the symptoms of lower abdominal pain, leukorrhagia, yellowness and stickiness caused by damp-heat blockage, lumbosacral aching pain, nerve fatigue, lack of force and the like. The medicinal materials have the effects of clearing heat, supplementing and performing qi and blood treatment simultaneously, thereby finally fulfilling the aims of regulating qi and blood, repairing endometrium and enhancing the organic immunity.

Description

A kind of Chinese medicinal enema for the treatment of chronic endometritis and preparation method thereof
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly a kind of Chinese medicinal enema for the treatment of chronic endometritis and preparation method thereof.
Background technology
Endometrium is the most common affected area, and pathogen is invaded by placental separation face, but due to the cytotoxin invaded different with the power of puerpera's resistance, the scope of inflammatory disorders also can difference.Acute endometritis remains fetal membrane, placenta tissue or laceration of cervix due to childbirth, miscarriage, premature rupture of fetal membrane, official jargon, and lochia, clot are detained uterine cavity etc., cause former vagina, the intracervical pathogen retrograde infection of being present in; During official jargon operation, menstrual hygiene sternly or is not noted by sterile working, and sexual intercourse in menstrual period etc. brings pathogen into uterine cavity; After uterine cavity and Radiotherapy of Carcinoma Cervix, intimal necrosis easy infection, endometrial polyp, fleshy polyp ulcer, necrosis also can cause infection.The lighter, inflammatory process is confined to the former Placenta Hominis attachment area of official jargon inner surface, then diffuses to full uterine decidua layer, generally often involves the shallow table muscle layer in uterus.Severe one then can to dark muscle layer.And even placenta percreta spreads, therefore endometritis often accompanies myometritis.Now tend to be referred to as uterine infection in puerperal.Infect and also can involve the other tissue in palace, be referred to as metritis companion pelvicellulitis.3 ~ 4d morbidity in puerperal, grade fever, is no more than 38.5 DEG C more, can have headache, drowsiness, and general malaise, is off one's feed, and lower abdomen dull pain or the aggravation of dolores postpartum pain, time lengthening, lochia amount is many, is often drabon color, frowziness.Gynecologial examination: the involution of uterus delays, matter is soft, and fundus of uterus has mild tenderness.Active treatment inflammation obtains effector, and downright bad internal film tissue comes off, and is repaired and fully recover at about 10 d.
According to above-mentioned clinical manifestation, colposcopy: find pus sample, band stink lochia, bimanual examination uterus has mild tenderness to make a definite diagnosis.The determination of pathogen infection, main dependence is got cavity of uterus secretions and is done antibacterial culturing.The cotton swab collecting specimen should have sleeve pipe, in case cervix uteri pollutes.Often infecting is anaerobe mixed infection, must send the laboratory of anaerobic culture condition.Based on General Symptoms, be more common in the infection that Hemolytic streptococcus causes, Abwehrkraft des Koepers is weak, when the virulence of pathogen is strong.Sometimes endometrium local patholoic change not obvious, as vaginal secretions is few, stink is not obvious.But there is the phenomenon such as shiver with cold, high heat, headache, pulse thin speed, hypogastralgia, leukocytosis.
In a word, examination per vagina repeatedly should be avoided, in case infect diffusion.One should start antibiotic therapy after diagnosing immediately, need not wait for antibacterial culturing and drug sensitivity tests.
Endometrial chronic inflammation is chronic endometritis.Can be changed by acute endometritis; Also can be spread by long-term salpingitis or serious cervicitis and form; There is intrauterine device, childbirth or post-abortion the subinvolution of a small amount of Placenta remnants and Placenta Hominis facies posterior hepatis also can cause chronic endometritis; Postclimacteric women, because body inner estrogen level reduces, endometrium and vagina inner membrance all become poor, easily by the invasion and attack of antibacterial, chronic inflammatory disease occur; In addition, submucosal myoma of uterus, mucosal polyp also can cause endometrial chronic inflammatory disease.
The cardinal symptom of chronic endometritis is irregular menstruation or metrorrhagia; Lower abdominal pain or falling inflation sense; Leucorrhoea grow in quantity; Fever etc.; In addition, uterus increases, and has tenderness, and the other surrounding tissue in uterus thickens tenderness.If old people has suffered from chronic endometritis, there will be post menopausal vaginal hemorrhage again, and had leucorrhoea grow in quantity, thinned out, courageous and upright.During treatment chronic endometritis, first should see the inducement with or without causing, as retained placental, intrauterine device etc.Remove these inducements, chronic endometritis can be fully recovered very soon.Otherwise antiinflammatory simply, curative effect also can not be remarkable.The intrauterine device laid should take out, puerperal or the chronic endometritis caused by post-abortion, should make careful dilatation and curettage of uterine and remove residual degeneration placenta tissue; Endometrial polyp is had to extract; As found, Submucous myoma or endometrial cancer according to circumstances should carry out active treatment; Senile endometrium is scorching, expansible cervical orifice, flows out in order to blood or juice.
Endometritis acute stage, endometrium is congested, edema, inflammatory cell infiltration, and suppurating appears in serious symptom person.The main manifestations of acute endometritis is heating, lower abdominal pain, leucorrhoea grow in quantity, be courage and uprightness or foul smelling sometimes, and uterus is bigger sometimes, and there is tenderness in uterus.Chronic person's performance is also substantially identical, and menorrhagia, lower abdominal pain and waist sacrum also can be had attached obviously swollen.Acute endometritis can be further development of myometritis, and salpingitis and pelvic inflammatory disease, aggravate disease.Women often can feel lower abdomen dull pain or falling inflation sense, psoas muscle portion pain, leucorrhoea grow in quantity, rare water sample, faint yellow or purulence, courage and uprightness.And can with irregular vagina bleeding or menostaxis, dysmenorrhea, amenorrhea.Uterus increase spherical in shape, soft, have tenderness, courage and uprightness, purulent secretion can be had to discharge.The omen of chronic endometritis that Here it is.About there is the chronic endometritis patient of 20% can be completely asymptomatic, but find when doing gynecologial examination by doctor.
The Etiological of endometritis:
Though one, endometrium has periodicity to strip off, its basal layer does not strip off thereupon, once basal layer has chronic inflammatory disease to get final product the functional layer of Long-term Infection inner membrance, causes chronic endometritis.
Two, long-standing adnexitis or serious cervicitis can cause chronic endometritis.
Three, intrauterine contraceptive loop can cause chronic endometritis.
Four, giving a birth or have post-abortion the healing of a small amount of Placenta remnants or Placenta Hominis attachment surface bad, is often the reason causing chronic endometritis.
Five, submucosal myoma of uterus, mucosal polyp also can cause chronic endometritis.
Six, the chronic endometritis without obvious inducement also can exist, and cause of disease castor is many from vagina and cervix uteri.
The general great majority of doctor trained in Western medicine use antibiotic therapy, as penicillin, streptomycin, erythromycin, gentamycin etc. can improve curative effect.But one fix on physician guidance under use.Chronic endometritis is through suitably treatment, and most humans can be cured.The confidence of healing must be established, adhere to treatment; Otherwise, will give up halfway.Therapeutic modality best is at present the method adopting traditional Chinese medical science conditioning and treating.Chinese traditional treatment effectively can solve the surface symptoms of disease, can solve pathogenic basic factor thoroughly again.Patient can also be suitable as the case may be selection physiotherapy.But patient will note must not at will medication, will carry out under the guidance of expert.For physiotherapy, also limited, can not be excessive, be unfavorable for the state of an illness excessively on the contrary, damage the health of patient.
Endometritis is the common frequently-occurring disease of gynecological, and because it has, the course of disease is long, the feature of easily recurrence.Become one of disease of serious harm WomanHealth, for the feature of endometritis, clinical treatment mainly adopts Antiinflammatory Regimen, as oral or intravenous drip antibiotic, coordinate the measures such as vaginadouche medicine-feeding simultaneously, later stage it is found that endometritis is also secreted with body inner estrogen and reduces relevant, and the reduction of body inner estrogen level can make endometrium thinning.More easily be subject to pathogenic bacterium invasion and attack and cause inflammation; Therefore add again oral estrogen and progestogen to improve endometrium function, but clinical therapeutic efficacy still can not get larger improvement, and many researcheres are expected to solve problem by Chinese medicine.
Summary of the invention
Technical problem to be solved by this invention is, doctor trained in Western medicine uses antibiotic therapy for the general great majority of this disease, as penicillin, streptomycin, erythromycin, gentamycin etc., easily repeatedly.Therapeutic modality best is at present the method adopting traditional Chinese medical science conditioning and treating.Chinese traditional treatment effectively can solve the surface symptoms of disease, can solve pathogenic basic factor thoroughly again.Patient can also be suitable as the case may be selection physiotherapy.But the traditional Chinese medical science is particular about and is suited the remedy to the case, individual variation is obvious, will carry out under the guidance of expert.For physiotherapy, also limited, can not be excessive, be unfavorable for the state of an illness excessively on the contrary, damage the health of patient.The present invention combines clinical experience for many years on the basis of traditional medicine, adopts modern processing method meticulously to develop.The present invention to each effective ingredient scientific compatibility of raw material medicine, focus of going directly, and instant effect, side effect is little, biocidal property is strong preparation, can efficient solution except the misery of patient, reach the object of dispelling disease.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicinal enema for the treatment of chronic endometritis, in Chinese medicinal enema described in it, the ratio of weight and number of various raw material can be: Herba Hedyotidis Diffusae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Caulis Sargentodoxae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Herba Andrographis 10 ~ 20 parts, Herba Scutellariae Barbatae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Senecionis Scandentis 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, Cortex Dictamni 10 ~ 20 parts.
The Chinese medicinal enema of described treatment chronic endometritis, in Chinese medicinal enema described in it, the ratio of weight and number of various raw material can also be: Herba Hedyotidis Diffusae 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Herba Patriniae 10 ~ 15 parts, Caulis Sargentodoxae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Rhizoma Curcumae 10 ~ 15 parts, Herba Taraxaci 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Herba Andrographis 10 ~ 20 parts, Herba Scutellariae Barbatae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Senecionis Scandentis 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, Cortex Dictamni 10 ~ 20 parts.
The Chinese medicinal enema of described treatment chronic endometritis, in Chinese medicinal enema described in it, the ratio of weight and number of various raw material also can be: Herba Hedyotidis Diffusae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Caulis Sargentodoxae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts, Radix Sophorae Flavescentis 10 ~ 15 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 parts, Herba Andrographis 10 ~ 15 parts, Herba Scutellariae Barbatae 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Herba Senecionis Scandentis 10 ~ 15 parts, Herba Menthae 10 ~ 15 parts, Cortex Dictamni 10 ~ 15 parts.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicinal enema of chronic endometritis, and described in it, the preparation process of enema comprises:
A, by Herba Menthae, Herba Andrographis, Herba Senecionis Scandentis and the Cortex Dictamni way of distillation are distilled into crystallization, for subsequent use, as component 1;
B, all the other raw materials to be soaked, extract three times, as component 2;
C, component 1 and component 2 to be stirred, pack after ultraviolet sterilization.
In described step b, described raw material can be soaked 30 minutes to 1 hour, heated and boiled 30 ~ 40 minutes, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into paste, becomes component 2.
For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method for the treatment of the Chinese medicinal enema of chronic endometritis, and described in it, the preparation process of enema comprises further:
A. by described crude drug except Herba Menthae, Herba Andrographis, puts into pulverizer outside Herba Senecionis Scandentis and Rhizoma Curcumae and is ground into granule;
B. the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times;
C. the medicinal residues after above-mentioned ethanol extraction are got again, the heating and refluxing extraction that adds water 2 times;
D. by Herba Menthae, Herba Andrographis, Herba Senecionis Scandentis and Cortex Dictamni distillation are vaporized to obtain crystallization, add in above-mentioned two kinds of extracting solution, stir, pack after ultraviolet sterilization.
In described step a, can by described crude drug except Herba Menthae, Herba Andrographis, Herba Senecionis Scandentis with put into pulverizer outside Rhizoma Curcumae and become granule then to soak ethanol 24 hours.
In described step b, soaked heating particles can be extracted 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.
In described step c, the medicinal residues that ethanol extraction is crossed can be put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, and 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, stand for standby use, becomes component 2.
In described steps d, can by Herba Menthae, Herba Andrographis, Herba Senecionis Scandentis and Rhizoma Curcumae distillation are vaporized to obtain crystallization, are dried to powder; Again above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.37 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, pack after ultraviolet radiation disinfection.
The using method of enema of the present invention: choose crude drug, enema can be prepared by the method that the invention provides embodiment, also can decoct as medicine soup 150-120ml with clear water 500ml, get that supernatant is cool is about 30-40 DEG C to medicine temperature, lateral position is got after advising patient's defecation, insert anus with anal canal and be about 20cm, inhale medicinal liquid with 50ml syringe and slowly pour into the capable retention enema of (or using transfusion device infusion) rectum from anal canal, the flat sleeping 1-2 hour of slightly padded buttocks after coloclysis, every day coloclysis 2-3 time, treating 7 days was 1 course for the treatment of.During per rectum administration, medicine at rectal absorption 50%-70%, and can directly not enter 3 Venous systems of pelvic cavity viscera by liver, makes pelvic inflammation rapid rehabilitation under medicine effective concentration effect.
The present invention has clearing away heat-damp and promoting diuresis, QI invigorating repercussive effect, is used for the treatment of that lower abdominal pain, leucorrhoea grow in quantity and yellow skin matter that damp and hot retardance causes are thick, the symptom such as lumbosacral aching pain and spiritlessness and weakness; Containing the Chinese medicine such as Herba Andrographis, Herba Patriniae and Rhizoma Curcumae in the present invention, Fructus Rosae Laevigatae has reinforcing the kidney and controlling nocturnal emission effect, and Herba Andrographis has clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling effect, and Pseudobulbus Bletillae (Rhizoma Bletillae) has that dampness removing dispels the wind, dissipate blood stasis effect; Combination is mended clearly in each taste medication of the present invention, QI and blood is ruled together, and finally reaches the object promoting QI and blood and tune, endometrium reparation and improve immunity of organisms.Research also finds, the present invention also has antibacterial, antiinflammatory, analgesia and on hemorheology impact, and these functions all can play good effect to endometritis, thus form good synergism with antibiotic; Clinical symptoms can be controlled in time in clinical, alleviate patient suffering, also can significantly improve cure rate simultaneously, reduce the recurrence after curing.
Detailed description of the invention
Endometritis is the common frequently-occurring disease of gynecological, and because it has, the course of disease is long, the feature of easily recurrence.Become one of disease of serious harm WomanHealth, for the feature of endometritis, clinical treatment mainly adopts Antiinflammatory Regimen, as oral or intravenous drip antibiotic, coordinate the measures such as vaginadouche medicine-feeding simultaneously, later stage it is found that endometritis is also secreted with body inner estrogen and reduces relevant, and the reduction of body inner estrogen level can make endometrium thinning.More easily be subject to pathogenic bacterium invasion and attack and cause inflammation; Therefore add again oral estrogen and progestogen to improve endometrium function, but clinical therapeutic efficacy still can not get larger improvement, many researcheres expect the treatment being solved problem endometritis by Chinese medicine, first when distinguishing cold and heat and deficiency and excess, belong to hot true person, anxious when heat-clearing and toxic substances removing, dampness removing leukorrhagia stopping, blood-activating analgetic, in case patient's condition is deeply; Belong to cold and belong to empty person, when with the method for warming the kidney to activate YANG, dispelling cold and removing dampness, blood-activating analgetic, in order to strengthening vital QI to eliminate pathogenic factors, in concrete therapy, the methods such as Orally-administered decoction, external application, acupuncture, coloclysis can be selected.
The traditional Chinese medical science thinks that endometritis is caused by hyperactivity of toxic heat, damp and hot retardance and cold and stagnate, and the present invention just has clearing away heat-damp and promoting diuresis, QI invigorating repercussive effect, be used for the treatment of that lower abdominal pain, leucorrhoea grow in quantity and yellow skin matter that damp and hot retardance causes are thick, the symptom such as lumbosacral aching pain and spiritlessness and weakness; Containing the eight taste Chinese medicines such as Herba Andrographis, Herba Patriniae and Herba Houttuyniae in the present invention, Fructus Rosae Laevigatae has reinforcing the kidney and controlling nocturnal emission effect, and Herba Andrographis has clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling effect, and Pseudobulbus Bletillae (Rhizoma Bletillae) has that dampness removing dispels the wind, dissipate blood stasis effect; Combination is mended clearly in each taste medication of the present invention, QI and blood is ruled together, and finally reaches the object promoting QI and blood and tune, endometrium reparation and improve immunity of organisms.Research also finds, the present invention also has antibacterial, antiinflammatory, analgesia and on hemorheology impact, and these functions all can play good effect to endometritis, thus form good synergism with antibiotic; Clinically middle two medicine couplings can be controlled clinical symptoms in time, alleviate patient suffering, also can significantly improve cure rate simultaneously, reduce the recurrence after curing.
Motherland's medical science thinks that this disease is many by hollow through row vessels of the uterus in puerperal, invades uterus in affection of exogenous damp pyretic toxicity; Or spleen is suffered from a deficiency of the kidney damage, retention of water-damp in the body is heat-transformation with the passing of time; Or surfeit delicious food savoury, interior life is damp and hot, bet uterus; Or fire caused by depression of liver-QI, phlegm-fire multiple abscess uterus, cause pelvic cavity viscera inner membrance QI-blood circulation not smooth, damp pyretic toxicity, phlegm-fire blood stasis are tied mutually, suppuration, infringement pelvic tissue.Control or wrong treatment owing to losing, cause recurrent exerbation, protracted course of disease, organ-tissue adhesion, hypertrophy form abdominal mass enclosed mass.This sick simulataneous insufficiency and excessive, the wet hot phlegm stasis of blood are suffered from mutually each other, and spleen damage of suffering from a deficiency of the kidney is it, and wet hot phlegm stasis blocking is stagnant is its mark.
Object of the present invention, is exactly all undesirable for the curative effect of the medicine of pelvic inflammatory disease in gynaecopathia, takes effect slower, large to human body side effect, comparatively large to body of women harm, and easy shortcoming repeatedly, a kind of instant effect of invention production, the medicine that side effect is little, biocidal property is strong, to remove the misery of patient.The present invention inherits the medical heritage of motherland, Traditional Chinese Medicine is developed, utilize Chinese herbal medicine resource advantage all over the mountains and plains, develop the Chinese medicine preparation of a kind of specially good effect, safety, convenience, inexpensive, pure natural, in order to treat the common gynecological diseases such as the various pelvic inflammatory disease of women, frequently-occurring disease, makes up Western medicine toxic and side effects large, endangers the defects such as dark to body of women.Preparation technology of the present invention is simple, and medicine material is cheap, good effect, can reach reasonable social effect and economic interests.The present invention has effect of blood circulation promoting and blood stasis dispelling, eliminating damp-heat, and for the pelvic inflammatory disease that the stagnation of QI is pented up, the diseases such as disease sees profuse leukorrhea, hypogastralgia, are applicable to the treatment of the commonly encountered diseases such as chronic pelvic inflammatory disease, chronic adnexitis, ovarian cyst, vaginitis, Be very effective simultaneously.This medical instrument has and dissolves fast, release advantage rapidly, reaches the object of rapid relief of symptoms and treatment.
Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.
Radix Paeoniae Rubra bitter in the mouth, is slightly cold.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Radix Paeoniae Rubra can purify the blood a point excess-heat, and dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between is for use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, can purify the blood a point excess-heat, can control fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for blood system excess-heat, be good at promoting blood circulation to remove blood stasis.
Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.
Herba Patriniae nature and flavor hardship is flat, has effect of heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs.Acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain can be cured.Enter stomach, large intestine, Liver Channel.Cure mainly heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the stagnant caused breast abdomen pain of the excess-heat stasis of blood, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.
Herba Taraxaci is the Chinese medicine commonly used simply, and its medical value is loaded various medical book early.Its all herbal medicine, containing compositions such as taraxasterol, taraxerol, taraxacin, caffeic acid, choline, inulin.The flat sweet and slightly bitter taste of property.Can heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Compendium of Material Medica is recorded: " heat clearing away poison, relieving dyspepsia poison, disappearing, evil is swollen, tuberculosis, furuncle are swollen for Detoxicating food-poisoning, loose stagnant gas." Herba Taraxaci hides sweet flat, its property is nontoxic.When being enter stomach into liver, the key medicine of antipyretic removing heat from blood.
Herba Andrographis is herb or the leaf of acanthaceous plant Herba Andrographis (Andrographis paniculata (Burm.f.) Nees).Have another name called Chun Lianqiuliu, Herba Andrographitis, Lan Helian, Radix Gentianae, golden Rhizoma et radix valerianae, Tremella aurantialba Bandoni et Zang hook, India's grass, Herba vallisneriae Spiralis etc.Bitter in the mouth, cold in nature.GUIXIN, lung, large intestine, urinary bladder channel.There are heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.Cure mainly bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc., external can treat furuncle toxic swelling, trauma infection contamination etc." Guangxi Chinese herbal medicine ": hemostasis removing heat from blood, removing toxic substances and promoting tissue regeneration, controls lung abscess, stomatitis.
Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.External is gynecological's good medicine of activating blood circulation to dissipate blood stasis.
Herba Hedyotidis Diffusae is again Herba Hedyotidis Diffusae, two leaves, Herba Commelinae Bengalensis, Chinese Lobelia.Mildly bitter flavor, sweet, cold.Enter stomach, large intestine, small intestine meridian, clearing up internal heat by using drugs of bitter in taste and cold in nature detoxifies, and sweet cold eliminating damp-heat, has stronger removing toxicity for eliminating carbuncles effect to carbuncle, pharyngalgia, snakebite etc.Be generally used for treatment sore, laryngopharynx swelling and pain, abdominalgia with intestinal abscess, venom, also for the puckery pain of pyretic stranguria, dysuria.The good medicine of damp eliminating of drawing out pus by applying a plaster to the affected part.
Fructus Rosae Laevigatae is the fruit of rosaceous plant Fructus Rosae Laevigatae, also known as Catunaregam spinosa (Thunb.) Tirveng., Fructus Rosae Normalis etc.Fructus Rosae Laevigatae is the famous medicine of the kidney invigorating simply.The traditional Chinese medical science is thought, Fructus Rosae Laevigatae sour in the mouth, and property is put down, and enters kidney, large intestine two warp, has reinforcing the kidney and controlling nocturnal emission, effect of reducing urination and antidiarrheal.Emission and spermatorrhea can be treated, frequent urination and enuresis, leukorrhagia, metrorrhagia, spontaneous perspiration, night sweat, cough due to deficiency of the lung, insufficiency of the spleen dysentery etc.Modern pharmacology research confirms: Fructus Rosae Laevigatae extract can extend the interval between micturition time; Contained tannin has stronger inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus etc.Fructus Rosae Laevigatae modern pharmacology proves: Fructus Rosae Laevigatae fruit is oral can promote that gastric secretion helps digest, and intestinal mucosa can be made again to shrink, and secretion reduces and antidiarrheal; Fructus Rosae Laevigatae decocting liquid all has stronger inhibitory action to staphylococcus aureus, escherichia coli, bacillus pyocyaneus, dysentery bacterium and influenza virus.1, controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents.Containing a large amount of acidic materials, soap one-tenth etc. in Fructus Rosae Laevigatae, can pass out semen lingering diarrhea, woman's leukorrhagia of man be prevented too much in controlling nocturnal emission with astringent drugs room, again can astringing intestine to stop diarrhea road, prevent the ineffective caused dysentery of insufficiency of the spleen constraint.2, reducing urination for preventing enuresis.Containing a large amount of acidic materials and Saponin in Fructus Rosae Laevigatae, there is restriction wing and take off sphincter, extend interval between micturition, increase each effect of discharging urine volume, can be used for the disease for the treatment of the enuresis and frequent micturition.3, relieving cough and asthma, spasmolytic.The traditional Chinese medical science is thought, breath with cough and how to be caused by abnormal rising of lung-QI, Fructus Rosae Laevigatae sour-puckery flavor, gas of astringing the lung, can relieving cough and asthma.Modern study finds, the composition containing anti-smooth muscle spasm in Fructus Rosae Laevigatae, can prevent the spasm of gastrointestinal and trachea.4, blood fat reducing.Economize alcohol, hot-tempered matter and soap formula etc. containing fatty acid, Bu Gu in Fructus Rosae Laevigatae, blood fat can be reduced, reduce fat in endovascular deposition, can be used for treating atherosclerosis.5, anti-inflammation.Research finds, Fructus Rosae Laevigatae extracting solution can kill staphylococcus aureus and escherichia coli etc., can be used to treat the disease caused because of S. aureus L-forms or coli-infection.
Caulis Sargentodoxae has another name called Caulis seu Radix Schisandrae Henryi, Folium Styracis Suberifoliae rattan, Rhizoma Homalomenae etc., is the stem of plants of Lardizabalaceae Caulis Sargentodoxae Sargentodoxa cuneata (Oliv.) Rehd.Et Wils..Be born in hillside sparse woods, small stream limit; There is cultivation.Main product Hubei, Sichuan, Jiangxi, Henan, Jiangsu; Anhui, Zhejiang are also produced.Nature and flavor are bitter, flat.There is the eliminating carbuncle that relieves internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide.Control acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, injury from falling down.
Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Pseudobulbus Bletillae (Rhizoma Bletillae) is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "; Compendium of Material Medica: " abnormal smells from the patient (root) is bitter, flat, nontoxic.
Herba Menthae is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.Place uses can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.All herbal medicine, pungent, cool.Return lung, Liver Channel, have and disperse wind heat, clearing throat, rash is detoxified, and dispersing the stagnated live-QI to relieve the stagnation of QI and the effect such as antipruritic, be applicable to the disease such as cold, fever, headache, laryngopharynx swelling and pain, lossless, wind-fire acute conjunctivitis, rubella, skin are itched, colic, dysentery and scrofula, external has slight analgesic effect, for neuralgia etc.
Radix Sophorae Flavescentis is bitter, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment colpitis mycotica, is often combined with Radix Sophorae Flavescentis, is the colpitic external use gynaecological good medicine for the treatment of.
Fructus Rubi plant can be used as medicine, and has multi-medicament to be worth, and its fruit has the effect of kidney invigorating and YANG supporting.Raspberry seed oil belongs to unsaturated fatty acid, can promote that the severe that of prostatic secretions covers.Effect: the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight.Make treatment index with the vaginal smear of rat, rabbit and inner membrance section, Fructus Rubi seemingly has estrogen-like effects.Bacteriostasis 100% decoct flat board burrows method, has inhibitory action, also have inhibitory action to vibrio cholera to staphylococcus.The indexs such as the vaginal smear of estrogen-like effects rat, rabbit and inner membrance section show, Fructus Rubi seemingly has estrogen-like effects.
Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria.Herba Leonuri alkalescence subcutaneous injection has central inhibitory action, and MLD is 0.4-0.6g/kg.Intravenous rabbit injection leonurine 1mg/kg, visible urine volume significantly increases.Leonurine can make Sanguis Leporis seu oryctolagi suspension generation haemolysis when higher concentration.Leonurine infusion tube dilution method 1: 13-1: 10, to achorion schoenleinii, Pilus Caprae seu Ovis sample sporidiole bacteria, epidermophyton rubrum, starlike nocadia all have inhibitory action.The dull and stereotyped paper disk method of Herba Leonuri decoct, has inhibitory action to escherichia coli, dysentery bacterium.Herba Leonuri can remove silt tissue regeneration promoting, promoting blood flow to regulate menstruation, containing the various trace elements such as selenium, manganese, can antioxidation, anti-aging, and there is pretty good beneficial face beauty treatment, anti-ageing anti-old effect.
Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: bitter in the mouth is so dampness; YIN-cold is so victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.
Rhizoma Curcumae is pungent, bitter, temperature.Return liver, spleen channel.Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.Effect: removing blood stasis promoting the circulation of QI to relieve pain: this product effect is similar to Rhizoma Sparganii, but warm concerted effort is comparatively large, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.Long-pending eliminating stagnation: this product energy circulation of qi promoting removing food stagnancy pain relieving, for eating accumulation, breast abdominal distention is vexed has a pain.Removing blood stasis, women's amenorrhea, or the lump in the abdomen addiction block of phlegm-damp congestion condensation.Jia Suoxue: " Rhizoma Curcumae acrid in the mouth is strong, specializes in the blood in gas, and main removing mass disappears heavily fortified point, goes to gather addiction block, amenorrhea blood stasis, flutters report pain.Quite same with Rhizoma Sparganii function, also cross clothes." (" medicineization justice ")
Cortex Dictamni dispels the wind, dampness, heat clearing away, removing toxic substances.Control wind heat sore, scabies, itchy skin eruption, rheumatic arthralgia, jaundice." herbal classic ": main wind syndrome of head, jaundice, cough with dyspnea, drenches drop, swells and ache in woman's the moon, the dead flesh of arthralgia chiefly caused by damp pathogen, unable to flex and stretch the extremities, start-stop, row step Herba Scutellariae Barbatae acrid in the mouth; Bitter; Cold in nature.Gui Jing: return lung meridian; Liver Channel; Kidney channel.Heat clearing away, removing toxic substances, dissipating blood stasis, hemostasis, inducing diuresis to remove edema, analgesic therapy.Control haematemesis, epistaxis, stranguria with blood, bloody dysentery, jaundice, have sore throat, lung abscess, furuncle, scrofula, sore, cancerous protuberance, traumatic injury knife injury, venom." Quanzhou book on Chinese herbal medicine ": heat clearing away, removing toxic substances, method wind, loose blood, circulation of qi promoting, diuretic, dredging collateral, removing blood stasis with potent drugs, pain relieving.Main stranguria with blood for oral administration, spits blood, epistaxis; External smelting venom, carbuncle, furuncle, innominate toxic swelling.
Herba Senecionis Scandentis, has another name called Herba Hieracii Umbellati, Herba Senecionis Scandentis.Latin name Herba Senecionis Scandentis.A kind of Chinese herbal medicine, under being born in hillside, sparse woods, Lin Bian, roadside, in limes marginis thick grass.The effects such as it is cold in nature, bitter in the mouth, has heat-clearing and toxic substances removing, improving eyesight, antipruritic.Be used for anemopyretic cold, conjunctival congestion and swelling pain, dysentery, skin eczema furuncle.Supplement to the Herbal: main pestilential pathogen, knot is yellow, malaria miasma, and cup poison, boils telling down of clothes, also smash the place of biting such as deposited skin ulcer, worm Serpentis dog.
The preparation process of enema of the present invention is: get Herba Hedyotidis Diffusae 1500g, Radix Salviae Miltiorrhizae 1500g, Caulis Spatholobi 1500g, Herba Leonuri 1500g, Herba Patriniae 1500g, Caulis Sargentodoxae 1500g, Radix Paeoniae Rubra 1500g, Herba Taraxaci 1500g, Radix Scutellariae 1500g, Fructus Rosae Laevigatae 1500g, Fructus Rubi 1500g, Radix Sophorae Flavescentis 1500g, Herba Scutellariae Barbatae 1500g, Radix Angelicae Sinensis 1500g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g, Cortex Dictamni 1500g, soak 30 minutes to 1 hour, heated and boiled 30 ~ 40 minutes, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into pasty state, then by Herba Menthae 1500g, Herba Andrographis 1500g, Herba Senecionis Scandentis 1500g and Rhizoma Curcumae 1500g, extract with steam distillation, obtain crystal, be mixed in mass obtained above after pulverizing; Pack after ultraviolet radiation.
The preparation process of enema of the present invention can also be: Herba Hedyotidis Diffusae 1200g, Radix Salviae Miltiorrhizae 1300g, Caulis Spatholobi 1100g, Herba Leonuri 1200g, Herba Patriniae 1200g, Caulis Sargentodoxae 1200g, Radix Paeoniae Rubra 1300g, Herba Taraxaci 1200g, Radix Scutellariae 1300g, Fructus Rosae Laevigatae 1200g, Fructus Rubi 1200g, Radix Sophorae Flavescentis 1200g, Herba Scutellariae Barbatae 1200g, Radix Angelicae Sinensis 1200g, Pseudobulbus Bletillae (Rhizoma Bletillae) 1200g, Cortex Dictamni 1300g, by described crude drug, puts into pulverizer and becomes granule then to soak ethanol 24 hours.Soaked heating particles is extracted 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, stand for standby use, becomes component 1.10 times of water gagings put into by the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, becomes component 2.Again by Herba Menthae 1200g, Herba Andrographis 1300g, Herba Senecionis Scandentis 1200g and Rhizoma Curcumae 1200g distillation is vaporized to obtain crystallization, is dried to powder; Again above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.37 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, pack after ultraviolet radiation disinfection.
The using method of enema of the present invention: choose crude drug, enema can be prepared by the method that the invention provides embodiment, also can decoct as medicine soup 150-120ml with clear water 500ml, get that supernatant is cool is about 30-40 DEG C to medicine temperature, lateral position is got after advising patient's defecation, insert anus with anal canal and be about 20cm, inhale medicinal liquid with 50ml syringe and slowly pour into the capable retention enema of (or using transfusion device infusion) rectum from anal canal, the flat sleeping 1-2 hour of slightly padded buttocks after coloclysis, every day coloclysis 2-3 time, treating 7 days was 1 course for the treatment of.During per rectum administration, medicine at rectal absorption 50%-70%, and can directly not enter 3 Venous systems of pelvic cavity viscera by liver, makes pelvic inflammation rapid rehabilitation under medicine effective concentration effect.Continuous use 7 days is a course for the treatment of.
Pharmacological toxicity is tested
One, antibacterial experiment
In body, antibacterial tests result shows, the animal of enema of the present invention to escherichia coli and Bacillus proteus has significant protective effect, can subtract the development of the state of an illness, reduces the mortality rate of animal; Antimicrobial test result shows, the prostatitis antibacterial of urinary system bolt to urinary system infection has antibacterial and bactericidal action in various degree; The prostatitic experimental result that affects of experimental rat is shown, the present invention can anti-bacteria infect after the weightening finish of urinary system body of gland, slow down the development of the state of an illness, suppress the Pathological morphologic change of prostata tissue; Within after administration 2-5 hour, the urine volume of animal can be made obviously to increase; Obvious cooling effect in 5 hours after the rabbit body temperature rising administration that fresh yeast is caused; The animal auricular concha swelling that xylol causes and have obvious inhibitory action to granuloma induced by implantation of cotton pellets tissue, and suppress the increase of capillary permeability; Certain inhibitory action is had to the pain that chemical substance stimulating animal peritoneum or thermal stimulus animal body surface cause.
Result of the test shows: Chinese medicinal enema experiment safety of the present invention.This medicine is 1: 150 to group B streptococcus, staphylococcus aureus, colibacillary minimal inhibitory concentration, gonococcus is 1: 150, Candida albicans is 1: 300, it is 5 minutes to the time of killing during 1: 20 dilution factor, be 10 minutes when 1: 50, being 20 minutes when 1: 100, is 40 minutes when 1: 200, is 8 hours when 1: 400.
Two, animal acute toxicity test research:
When the present invention adopts rectal delivery, the maximum dosage-feeding on the one recording mice is 62.7g/kg (in medicated powder), be about 1567.5 times (people is in 60kg) intending clinical people's consumption, the maximum dosage-feeding 62.7g/kg (in medicated powder) on the one of rat, is about 1567.5 times that intend clinical people's consumption.The equal Continuous Observation of laboratory animal one week, its outward appearance sign, the mental status, diet, drinking-water, feces etc. are showed no obvious abnormalities.At the end of experiment, all healthy survival of animal, body weight increases.
Three, long-term toxicity test for animals research:
This test establishes medicine of the present invention high, in, low dose group and Matrix controls group, blank group, rectal delivery is adopted to give rat, dosage is respectively 3.2, 2.4 and 1.6g/kg (in medicated powder), be equivalent to intend 80 of clinical patient consumption [0.04g (medicated powder)/kg], 60 and 40 times, successive administration 2 months, in administration process, the body weight of each administration group and matrix group rat, dietary amount, outward appearance sign, behavioral activity, the mental status, hair color, feces character compares with blank group, no significant difference (P > 0.05), the weight of animals increasing value and Main Organ Coefficients and blank group comparing difference are not significantly (P > 0.05), hematology and the indivedual index of blood parameters check result administration group and blank group comparing difference are significantly (P < 0.05), but convalescent period terminates rear discrepant hematology and blood parameters has recovered normal all, other indexs and blank comparing difference are not significantly (P > 0.05), administration phase and convalescent period histological examination high dose group animal main organs compare with blank group and have no notable difference, have no slowness toxicity to occur.
Four, animal local excitation test:
The allergic reaction on guinea pigs of enema of the present invention and Rat-rectum medication irritation test.
Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.
Five, vaginal mucomembranous irritant test result
1. test method:
After laboratory animal is quarantined 3 days, select 18 above-mentioned healthy rabbits, be divided into three groups at random, often organize each 6, be respectively: blank, excipient control, enema group of the present invention (by application liquid 5 times of concentration).Be placed in excipient control group and the intravaginal of tested material treated animal with the sterilizing cotton sliver leaching of suitable size with sterile saline and tested material respectively, contact 6 hours with vaginal mucosa, after 24 hours, put to death animal.Taking-up topical vaginal tissue, observes pathological changes situation.
2, result of the test: vaginal mucomembranous irritant test result
Six, long term toxicity test data
1, experimental technique
Random for Cavia porcellus part is become 4 groups, often organizes 15.In guinea pig back spinal column both sides, depilatory is evenly coated, make its scope about 40 square centimeters of losing hair or feathers.Clean depilatory, treat and often organize Cavia porcellus after 24 hours and be coated with enema solution 0.2,0.4 of the present invention and 0.8ml respectively, respectively containing crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, the ordinary circumstance for the treatment of Cavia porcellus, experiment terminates rear execution animal and carries out hematology, blood biochemical and pathological examination.
2, result
Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicinal enema long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.
Result of the test shows: Chinese medicinal enema experiment safety of the present invention.This medicine is 1: 150 to group B streptococcus, staphylococcus aureus, colibacillary minimal inhibitory concentration, gonococcus is 1: 150, Candida albicans is 1: 300, it is 5 minutes to the time of killing during 1: 20 dilution factor, be 10 minutes when 1: 50, being 20 minutes when 1: 100, is 40 minutes when 1: 200, is 8 hours when 1: 400.
Pharmacodynamics test
Intestinal adhesion clinical manifestation is with knowing that block up disease conforms to, and as abdominal mass, abdomen localized pain is also shown in hemorheology change etc.Therefore manually can manufacture animal intestine adhesion as Blood stasis pathological model.
Experimental technique: get some, body weight is 300 ± 20 grams of female rat, be placed in after being full of the interior anesthesia of ether gas container, abdominal part cropping, sterilization, aseptically perform the operation, longitudinally 3 ~ 4cm otch is cut along abdomen median line, after finding vermiform appendix, at distance vermiform appendix cecum 0.5cm place, do the stringer holostrome mouth that a 2.0 ~ 2.5cm is long, the feces of vermiform appendix intracavity is all removed totally with aseptic absorbent cotton, then otch No. 1 silk thread densification is sewed up (notching edge ploughs under vermiform appendix intracavity completely), two-layer pass abdomen.And Post operation rat is divided into 5 groups at random, be respectively enema of the present invention (method shown in embodiment 1 obtains) 10g/kg, 5g/kg group, DANER FUKANG JIANGAO agent (Kuning Dianhong Pharmaceutical Co., Ltd.'s development) 10g/kg group, the scorching clean group of 30g/kg group of woman and model group 30ml/kg ordinary water.Post operation second day, each group anus intraperitoneal administration respectively, every day 1 time, continuous 7 days.Within 8th day, by sacrifice of animal, cut open the belly, observe intestinal adhesion degree, adhesion incidence rate and average adhesion place number.Adhesion grading standard is as follows: "+" singly locates adhesion, and matter is crisp, cannot label taking this; " ++ " singly locates adhesion, and firmly, easy label taking originally; " +++ " two places adhesion, firmly, easy label taking is originally; " ++++" the above adhesion in three places, firmly, easy label taking is originally.Experimental result sees the following form:
Note: compare * * p < 0.01 with model
Upper table result shows, adopts said method can cause intestinal adhesion model (model all intestinal adhesion occurs).Each administration group adhesion number of cases, compares with model group, and through X2 inspection, height agent 10g/kg group of the present invention and DANER FUKANG JIANGAO agent group all have obvious diversity (P < 0.01), and all the other two groups of effects are not obvious.Observe from adhesion degree, each administration group forms adhesion, the adhesion degree of large intestine also than model group be gently (because of each administration group number of cases very little, cannot statistical disposition).Viewed from average adhesion number, each administration group is all few according to model group.Above-mentioned experimental result shows, enema of the present invention has certain anti-experimental character intestinal adhesion effect.
Clinical trial:
In female reproductive system catches, endometritis is common disease.If the state of an illness can not be effectively controlled, myometrium may be affected and develop into myometritis, cause endometritis reason numerous, common causative reason has miscarriage, lays contraceptive device, menstrual phase sexual intercourse, body inner estrogen decline and intravaginal acidity reduction etc., all can bring out endometritis above.Clinical treatment endometritis often gives oral antibiotic and artificial cycle estrogen and progestogen, and coordinate vaginadouche medicine-feeding, this traditional remedies is under suspicion in recent years simultaneously.Come from above therapy and be also in the symptomatic treatment stage, thus clinical case through treatment after relapse rate high, prognosis is out of condition.
Endometritis is endometrial inflammation.Acute and chronic two kinds can be divided into by course of disease length.Occur after endometritis, often there is edema, ooze out in uterine cavity, acute stage also can cause General Symptoms, occurs heating, shiver with cold, leukocyte increase, lower abdomen falling inflation pain, leucorrhoea grow in quantity, sometimes uterus be bigger, touch a tender spot.Since two thousand eight, the author is from intending enema treatment chronic endometritis 30 example, satisfactory effect.Now be described below.
1 clinical data
56 examples are out-patient, minimum 22 years old of age, maximum 56 years old.Acute 26 examples, chronic 30 examples.Comprehensive Clinical performance conclusion has following several: lower abdomen falling pain, and lumbosacral region is ached; Vaginal secretions increases, and is generally thin water sample or faint yellow, is even courageous and upright sometimes; Menstrual period rule or irregular, but through amount multiplication or hemorrhage incessantly dripping, or low grade fever: dysmenorrhea.During inspection, uterus is bigger, and matter is soft and have tenderness.30 routine chronic patients all by inquiry medical history, gynecologial examination, leucorrhea chemical examination, TCT inspections, ultrasound diagnosis, examine scrape, endometrial biopsy, CA.125 inspection etc. in conjunction with clinical analysis, Differential Diagnosis, eliminating cancer and the patient of tuberculosis.
2 Therapeutic Method
From plan enema composition: Herba Hedyotidis Diffusae 15g, Radix Salviae Miltiorrhizae 12g, Caulis Spatholobi 13g, Herba Leonuri 12g, Herba Patriniae 13g, Caulis Sargentodoxae 12g, Radix Paeoniae Rubra 11g, Rhizoma Curcumae 13g, Herba Taraxaci 13g, Radix Scutellariae 12g, Fructus Rosae Laevigatae 13g, Fructus Rubi 12g, Radix Sophorae Flavescentis 12g, Pseudobulbus Bletillae (Rhizoma Bletillae) 11g, Herba Andrographis 12g, Herba Scutellariae Barbatae 13g, Radix Angelicae Sinensis 12g, Herba Senecionis Scandentis 12g, Herba Menthae 12g, Cortex Dictamni 12g.Enema can be prepared by the method that the invention provides embodiment, also can decoct as medicine soup 150-120ml with clear water 500ml, get that supernatant is cool is about 30-40 DEG C to medicine temperature, lateral position is got after advising patient's defecation, insert anus with anal canal and be about 20cm, inhale medicinal liquid with 50ml syringe and slowly pour into the capable retention enema of (or using transfusion device infusion) rectum from anal canal, the flat sleeping 1-2 hour of slightly padded buttocks after coloclysis, every day coloclysis 2-3 time, treating 7 days was 1 course for the treatment of.During per rectum administration, medicine at rectal absorption 50%-70%, and can directly not enter 3 Venous systems of pelvic cavity viscera by liver, makes pelvic inflammation rapid rehabilitation under medicine effective concentration effect.Continuous use 7 days is a course for the treatment of.
1 ~ 2 course for the treatment of of clinical observation, follow up a case by regular visits to 3 months.
3 observation of curative effect
3.1 criterion of therapeutical effect
Recovery from illness: the various conscious abnormal symptom of patient and sign disappear, and next time through carrying out periods rules, amount, color, matter are normal; Without recurrence in follow-up study 3 months.Effective: the various conscious abnormal symptom of patient and sign partial disappearance.Invalid: the various conscious abnormal symptom of patient and sign slightly alleviate or repeatedly occur again.
3.2 result
After treating 3 courses for the treatment of, recovery from illness 25 example, accounts for 83.33%; Effective 3 examples, account for 10%; Invalid 2 examples, account for 6.7%.Total effective rate is 93.33%.
4 know from experience
The present invention is used for postnatal blood stasis and adds cold internal resistance and cause lochia, stomachache, function promoting tissue regeneration by removing blood stasis and property temperature slightly partially.Full side all has good effect to the endometrium active chronic inflammation caused by a variety of causes.In the treatment, dialectical suitable plus-minus; For incomplete abortion or postpartum placenta fetal membrane residual etc. for removing intrauterine residue time, Radix Paeoniae Rubra conducting blood to flow downwards can be added.Found by clinical observation, use we to substitute the clearing heat in the pericardium, both safe and effective, can patient suffering be alleviated again.To septic abortion, missed abortion and row dilatation and curettage difficulty the greater, especially there is advantage.Modern medicine study shows, the present invention is as the agent of pure Chinese medicine, and this medicine has no side effect, determined curative effect, and price economy is economical, is easy to promote.
The traditional Chinese medical science thinks that endometritis is caused by hyperactivity of toxic heat, damp and hot retardance and cold and stagnate, and the present invention just has clearing away heat-damp and promoting diuresis, QI invigorating repercussive effect, be used for the treatment of that lower abdominal pain, leucorrhoea grow in quantity and yellow skin matter that damp and hot retardance causes are thick, the symptom such as lumbosacral aching pain and spiritlessness and weakness; Containing the eight taste Chinese medicines such as Herba Andrographis, Herba Patriniae and Herba Houttuyniae in the present invention, Semen Cuscutae has reinforcing the kidney and controlling nocturnal emission effect, and Herba Andrographis has clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling effect, and Fructus Cnidii has that dampness removing dispels the wind, dissipate blood stasis effect; Combination is mended clearly in each taste medication of the present invention, QI and blood is ruled together, and finally reaches the object promoting QI and blood and tune, endometrium reparation and improve immunity of organisms.Research also finds, the present invention also has antibacterial, antiinflammatory, analgesia and on hemorheology impact, and these functions all can play good effect to endometritis, thus form good synergism with antibiotic; Clinically middle two medicine couplings can be controlled clinical symptoms in time, alleviate patient suffering, also can significantly improve cure rate simultaneously, reduce the recurrence after curing.
In sum, the present invention's Chinese medicinal enema treats endometritis, satisfactory effect is obtained in clinical, by analyzing prescription of the present invention and effect, find that two medicine couplings can produce good synergism, although the two medicine mechanisms of action are different, all comparatively high inhibition effect is played to the pathogenesis of endometritis, can timely and effective control clinical symptoms, also can improve therapeutic effect and reduce relapse rate.
Specific embodiment: patient pays certain, female, 26 years old, married, the first visit date: on December 22nd, 2011.Patient's menstruation rule at ordinary times, in certain private outpatient service row artificial abortion, there is irregular vagina bleeding in postoperative 1 week in late August, 2011, stomachache, lumbago, invalid through antiinflammatory, hemostatic treatment 2 weeks.Change FUYANJING PIAN, FULE CHONGJI etc. into, hemorrhagely only stop first quarter moon.Within later 2 months, take FUYANJING PIAN, ZHIXUEBAO JIAONANG etc. always, but hemorrhage still time many time few, dripping urine endlessly, then to our hospital.Gynecologial examination: chronic endometritis, vaginal congest, rotten in cervix uteri lower lip, thicken tenderness on the right side of adnexa, palace body normal in size, leucorrhea microscopy: erythrocyte (+), pyocyte (+++), card belongs to the heresy stagnant dai channel of a specified duration of turbid damp, stagnation of blood stasis and heat becomes leukorrhagia, control suitable dampness, heat clearing away, dampness removing.Fang Yong: Herba Hedyotidis Diffusae 15g, Radix Salviae Miltiorrhizae 12g, Caulis Spatholobi 13g, Herba Leonuri 12g, Herba Patriniae 13g, Caulis Sargentodoxae 12g, Radix Paeoniae Rubra 11g, Rhizoma Curcumae 13g, Herba Taraxaci 13g, Radix Scutellariae 12g, Fructus Rosae Laevigatae 13g, Fructus Rubi 12g, Radix Sophorae Flavescentis 12g, Pseudobulbus Bletillae (Rhizoma Bletillae) 11g, Herba Andrographis 12g, Herba Scutellariae Barbatae 13g, Radix Angelicae Sinensis 12g, Herba Senecionis Scandentis 12g, Herba Menthae 12g, Cortex Dictamni 12g.Enema can be prepared by the method that the invention provides embodiment, also can decoct as medicine soup 150-120ml with clear water 500ml, get that supernatant is cool is about 30-40 DEG C to medicine temperature, lateral position is got after advising patient's defecation, insert anus with anal canal and be about 20cm, inhale medicinal liquid with 50ml syringe and slowly pour into the capable retention enema of (or using transfusion device infusion) rectum from anal canal, the flat sleeping 1-2 hour of slightly padded buttocks after coloclysis, every day coloclysis 2-3 time, treating 7 days was 1 course for the treatment of.After the course for the treatment of, hemorrhagely to reduce day by day, color gradually turns red, and soreness of waist abdominal distention alleviates, then uses a course for the treatment of, and hemorrhage stomachache is all stopped.On January 16th, 2012, menstrual onset, examined January 17, still the same with front, and all cards calm down.Through carrying out periods rules, menstrual period 4d, without stomachache, the soreness of waist.Within 3 months, follow up a case by regular visits to without recurrence.

Claims (10)

1. treat the Chinese medicinal enema of chronic endometritis for one kind, it is characterized in that, in described Chinese medicinal enema, the parts by weight of various raw material comprise: Herba Hedyotidis Diffusae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Caulis Sargentodoxae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Herba Andrographis 10 ~ 20 parts, Herba Scutellariae Barbatae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Senecionis Scandentis 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, Cortex Dictamni 10 ~ 20 parts.
2. treat the Chinese medicinal enema of chronic endometritis according to claim 1, it is characterized in that, in described Chinese medicinal enema, the parts by weight of various raw material comprise: Herba Hedyotidis Diffusae 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Herba Patriniae 10 ~ 15 parts, Caulis Sargentodoxae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Rhizoma Curcumae 10 ~ 15 parts, Herba Taraxaci 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Fructus Rosae Laevigatae 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Radix Sophorae Flavescentis 10 ~ 20 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Herba Andrographis 10 ~ 20 parts, Herba Scutellariae Barbatae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Senecionis Scandentis 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, Cortex Dictamni 10 ~ 20 parts.
3. treat the Chinese medicinal enema of chronic endometritis according to claim 1, it is characterized in that, in described Chinese medicinal enema, the parts by weight of various raw material comprise: Herba Hedyotidis Diffusae 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Caulis Sargentodoxae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Herba Taraxaci 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Fructus Rosae Laevigatae 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts, Radix Sophorae Flavescentis 10 ~ 15 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 parts, Herba Andrographis 10 ~ 15 parts, Herba Scutellariae Barbatae 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Herba Senecionis Scandentis 10 ~ 15 parts, Herba Menthae 10 ~ 15 parts, Cortex Dictamni 10 ~ 15 parts.
4. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicinal enema of chronic endometritis, it is characterized in that, the preparation process of described enema comprises:
A, by Herba Menthae, Herba Andrographis, Herba Senecionis Scandentis and the Cortex Dictamni way of distillation are distilled into crystallization, for subsequent use, as component 1;
B, all the other raw materials to be soaked, extract three times, as component 2;
C, component 1 and component 2 to be stirred, pack after ultraviolet sterilization.
5. treat the preparation method of the Chinese medicinal enema of chronic endometritis according to claim 4, it is characterized in that, in described step b, described raw material is soaked 30 minutes to 1 hour, heated and boiled 30 ~ 40 minutes, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 30 ~ 40 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, for the third time heated and boiled 30 ~ 40 minutes, filters; Three filtrates be combined, heating is concentrated into paste, becomes component 2.
6. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicinal enema of chronic endometritis, it is characterized in that, the preparation process of described enema comprises further:
A. by described crude drug except Herba Menthae, Herba Andrographis, puts into pulverizer outside Herba Senecionis Scandentis and Cortex Dictamni and is ground into granule;
B. the particulate matter be left after sieving is put into ethanol heating and refluxing extraction 2 times;
C. the medicinal residues after above-mentioned ethanol extraction are got again, the heating and refluxing extraction that adds water 2 times;
D. by Herba Menthae, Herba Andrographis, Herba Senecionis Scandentis and Cortex Dictamni distillation are vaporized to obtain crystallization, add in above-mentioned two kinds of extracting solution, stir, pack after ultraviolet sterilization.
7. the preparation method of enema according to claim 6, is characterized in that, in described step a, by described crude drug except Herba Menthae, Herba Andrographis, Herba Senecionis Scandentis with put into pulverizer outside Cortex Dictamni and become granule then to soak ethanol 24 hours.
8. the preparation method of enema according to claim 6, is characterized in that, in described step b, soaked heating particles is extracted 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, stand for standby use, becomes component 1.
9. the preparation method of enema according to claim 6, it is characterized in that, in described step c, 10 times of water gagings put into by the medicinal residues crossed by ethanol extraction, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, and 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated into paste, stand for standby use, becomes component 2.
10. the preparation method of enema according to claim 6, is characterized in that, by Herba Menthae in described steps d, and Herba Andrographis, Herba Senecionis Scandentis and Cortex Dictamni distillation are vaporized to obtain crystallization, are dried to powder; Again above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.37 filtrate, reclaim ethanol, by gained filtrate adjustment proportion to 1.06, pack after ultraviolet radiation disinfection.
CN201410620608.4A 2014-11-06 2014-11-06 Chinese medicinal enema for treating chronic endometritis and preparation method thereof Pending CN104338086A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106075218A (en) * 2016-07-25 2016-11-09 湖南中医药大学 A kind of Chinese medicine of Enem-d treatment gynaecopathia and its preparation method and application

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
姜劲挺等主编: "《中医脊柱相关疾病学》", 30 April 2012 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106075218A (en) * 2016-07-25 2016-11-09 湖南中医药大学 A kind of Chinese medicine of Enem-d treatment gynaecopathia and its preparation method and application

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