CN106075218A - A kind of Chinese medicine of Enem-d treatment gynaecopathia and its preparation method and application - Google Patents

Abstract

The invention discloses Chinese medicine of a kind of Enem-d treatment gynaecopathia and its preparation method and application, this Chinese medicine is made up of according to the raw material of weight portion following: Herba Taraxaci 25 35 parts, Herba Patriniae 25 35 parts, Rhizoma Smilacis Glabrae 25 35 parts, Caulis Sargentodoxae 25 35 parts, Caulis Spatholobi 25 35 parts, Cortex Magnoliae Officinalis 48 parts, Herba Hedyotidis Diffusae 25 35 parts, Rhizoma Polygoni Cuspidati 25 35 parts.Herba Taraxaci, Herba Patriniae, Rhizoma Smilacis Glabrae, Caulis Sargentodoxae are pulverized, sieve, adds 75% ethanol solution heated and stirred and process, cross leaching filtrate；Caulis Spatholobi, Cortex Magnoliae Officinalis, Herba Hedyotidis Diffusae, Rhizoma Polygoni Cuspidati are pulverized, sieved, adds citric acid alcoholic solution and extract 2 times, be concentrated to give concentrated solution；Filtrate is i.e. obtained Chinese medicine with the stirring of concentrated solution Hybrid Heating, supersound process.The Chinese medicine of the present invention is antibacterial extensively, it is possible to effectively kill the pathogenic bacterium such as trichomonas vaginitis, mycete, treats various gynaecopathia, short treating period, instant effect, has no side effect, and treating both the principal and secondary aspects of a disease controls difficulty in relapse after healing.

Description

A kind of Chinese medicine of Enem-d treatment gynaecopathia and its preparation method and application

Technical field

The present invention relates to pharmaceutical technology field, the Chinese medicine of a kind of Enem-d treatment gynaecopathia and preparation thereof Methods and applications.

Background technology

Gynaecopathia has: various vaginitiss, pelvic inflammatory disease, cervicitis, adnexitis, hysteromyoma, urethritis；Dysmenorrhea, amenorrhea, Menoxenia, pudendal pruritus, leucorrhea abnormal, artificial abortion etc..According to statistics, Chinese 40% women suffers from gynaecopathia in various degree, married Women 20%-70% suffers from dissimilar vaginitis, and 23%-49% suffers from cervicitis and cervical erosion.Woman vagina inwall wrinkles Pleat moistens, and secretions is many, easily suffers the invasion and attack of pathogenic bacteria and infection inflammation.The lighter's Pruritus, abnormal flavour, leucorrhea abnormal, severe one induces Endometritis, adnexitis, pelvic inflammatory disease, affect love life, brings disaster to household's health, even loses fertility.Gynaecopathia is not Treatment in time, except causing inflammation in addition to each physiological site mutually spreads with cross infection, also can bring many complication, very To causing the malignant change at some position, to healthy very harmful.Some gynaecopathia not only endanger women, but also Household can be involved, if pregnant female, also can cause the link such as intrauterine infection, birth canal infection, infect neonate, stream can be caused The serious consequences such as product, premature labor, congenital development deformity, mental retardation.

Summary of the invention

It is an object of the invention to provide a kind of short treating period, instant effect, have no side effect, treating both the principal and secondary aspects of a disease, be difficult to after healing Chinese medicine of Enem-d treatment gynaecopathia of recurrence and its preparation method and application, to solve to propose in above-mentioned background technology Problem.

For achieving the above object, the present invention provides following technical scheme:

The Chinese medicine of a kind of Enem-d treatment gynaecopathia, is made up of according to the raw material of weight portion following: Herba Taraxaci 25- 35 parts, Herba Patriniae 25-35 part, Rhizoma Smilacis Glabrae 25-35 part, Caulis Sargentodoxae 25-35 part, Caulis Spatholobi 25-35 part, Cortex Magnoliae Officinalis 4-8 part, Agkistrodon SHECAO 25-35 part, Rhizoma Polygoni Cuspidati 25-35 part.

As the further scheme of the present invention: the Chinese medicine of described Enem-d treatment gynaecopathia, by following according to weight The raw material composition of amount part: Herba Taraxaci 28-32 part, Herba Patriniae 28-32 part, Rhizoma Smilacis Glabrae 28-32 part, Caulis Sargentodoxae 28-32 part, Caulis Spatholobi 28-32 part, Cortex Magnoliae Officinalis 5-7 part, Herba Hedyotidis Diffusae 28-32 part, Rhizoma Polygoni Cuspidati 28-32 part.

As the further scheme of the present invention: the Chinese medicine of described Enem-d treatment gynaecopathia, by following according to weight The raw material composition of amount part: Herba Taraxaci 30 parts, Herba Patriniae 30 parts, Rhizoma Smilacis Glabrae 30 parts, Caulis Sargentodoxae 30 parts, Caulis Spatholobi 30 parts, Cortex Magnoliae Officinalis 6 Part, Herba Hedyotidis Diffusae 30 parts, Rhizoma Polygoni Cuspidati 30 parts.

It is a further object of the present invention to provide the preparation method of Chinese medicine of a kind of Enem-d treatment gynaecopathia, by with Lower step forms:

1) Herba Taraxaci, Herba Patriniae, Rhizoma Smilacis Glabrae, Caulis Sargentodoxae are pulverized, cross 80 mesh sieves, add the 75% of four Chinese medicine quality 18 times Ethanol solution, at 55-57 DEG C, heated and stirred processes 1.5-1.6h, then heated and stirred 3.5-4h at 65-68 DEG C, crosses leaching filter Liquid；

2) Caulis Spatholobi, Cortex Magnoliae Officinalis, Herba Hedyotidis Diffusae, Rhizoma Polygoni Cuspidati are pulverized, crossed 100 mesh sieves, add the Fructus Citri Limoniae of four Chinese medicine quality 8 times Acid alcohol solution extracts 2 times, and in citric acid alcoholic solution, the mass content of citric acid is 3-4%, and extraction temperature is 70-72 DEG C, extraction Time is 3-3.2h, merges lixiviating solution, is concentrated into the 25-28% of original volume, prepares concentrated solution；

3) filtrate is mixed with concentrated solution, heated and stirred 40-50min at 72-75 DEG C, then carry out supersound process 30- 35min, obtains Chinese medicine, and wherein ultrasonic power is 800W.

It is yet another object of the invention to provide the application in preparation treatment treatment medicine for gynecopathy of the described Chinese medicine.

Herba Taraxaci heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.Cure mainly furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung Carbuncle, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Herba Patriniae has heat-clearing and toxic substances removing, the effect of evacuation of pus of eliminating the phlegm, and is usually used in acute appendicitis, lung abscess, dysentery, and postnatal blood stasis is suffered from abdominal pain, Carbuncle furuncle.

Rhizoma Smilacis Glabrae has removing toxic substances, dehumidifying, and effect of easing joint movement is mainly used in the limbs contracture caused by syphilis and mercurialism, Bones and muscles pain；Damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies.

Caulis Sargentodoxae has heat-clearing and toxic substances removing, invigorates blood circulation, effect of wind-expelling pain-stopping.For abdominalgia with intestinal abscess, pathopyretic ulcer, amenorrhea, bitterly Warp, tumbling and swelling, rheumatic arthralgia.

Caulis Spatholobi has blood circulation promoting and enriching, menstruction regulating and pain relieving, effect of relaxing muscles and tendons and activating QI and blood in the collateral.For menoxenia, dysmenorrhea, amenorrhea, wind Pain of dampness syndrome, paralysis and numbness, blood deficiency and yellow complexion.

Cortex Magnoliae Officinalis dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.Curing mainly humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed heavily Cough.

Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, dampness removing is treating stranguria.Cure mainly dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, poisonous snake Bite, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, cancerous protuberance.

Rhizoma Polygoni Cuspidati has dampness removing jaundice eliminating, heat-clearing and toxic substances removing, eliminating stasis to stop pain, effect of relieving cough and resolving phlegm.For jaundice due to damp-heat, stranguria with turbid discharge, Leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus, burn due to hot liquid or fire, amenorrhea, lump in the abdomen, instep beats damage, cough due to lung-heat.

Compared with prior art, the invention has the beneficial effects as follows:

Chinese medicine of the present invention is pure Chinese medicinal preparation, has blood circulation promoting and blood stasis dispelling, unimpeded meridians, clear under the synergism of each raw material Thermal detoxification, anti-inflammatory analgetic, nourishing blood for regulating menstruation, liver and kidney tonifying, warm palace pain relieving, effect of dampness leukorrhagia stopping, antibacterial extensively, it is possible to effectively kill Go out the pathogenic bacterium such as trichomonas vaginitis, mycete, gonococcus, chlamydia, treat various gynaecopathia, vaginitiss various to women, pus and blood band, Pruritus vulvae and uterine prolapse, the prolapse of the uterus etc. have good effect, are particularly suited for pelvic inflammation；Short treating period, instant effect, nontoxic Side effect, will not cause any gastrointestinal upset to react, treating both the principal and secondary aspects of a disease, controls difficulty in relapse after healing, repairs birth canal, alleviating pain, goes back The muscle arthrosis pain causing dysmenorrhea all has significant curative effect.

Detailed description of the invention

Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, Obviously, described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based in the present invention Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, all Belong to the scope of protection of the invention.

Embodiment 1

In the embodiment of the present invention, the Chinese medicine of a kind of Enem-d treatment gynaecopathia, by following former according to weight portion Material composition: Herba Taraxaci 25 parts, Herba Patriniae 25 parts, Rhizoma Smilacis Glabrae 25 parts, Caulis Sargentodoxae 25 parts, Caulis Spatholobi 25 parts, Cortex Magnoliae Officinalis 4 parts, Agkistrodon SHECAO 25 parts, Rhizoma Polygoni Cuspidati 25 parts.

Herba Taraxaci, Herba Patriniae, Rhizoma Smilacis Glabrae, Caulis Sargentodoxae being pulverized, cross 80 mesh sieves, the volume adding four Chinese medicine quality 18 times is dense Degree is 75% ethanol solution, and at 55 DEG C, heated and stirred processes 1.5h, then heated and stirred 3.5h at 65 DEG C, crosses leaching filtrate. Caulis Spatholobi, Cortex Magnoliae Officinalis, Herba Hedyotidis Diffusae, Rhizoma Polygoni Cuspidati are pulverized, crossed 100 mesh sieves, adds the citric acid alcoholic solution leaching of four Chinese medicine quality 8 times Carrying 2 times, in citric acid alcoholic solution, the mass content of citric acid is 3%, and extraction temperature is 70 DEG C, and extraction time is 3h, merges leaching Extract, is concentrated into the 25% of original volume, prepares concentrated solution.Filtrate is mixed with concentrated solution, heated and stirred 40min at 72 DEG C, Then carrying out supersound process 30min, obtain Chinese medicine, wherein ultrasonic power is 800W.

Embodiment 2

In the embodiment of the present invention, the Chinese medicine of a kind of Enem-d treatment gynaecopathia, by following former according to weight portion Material composition: Herba Taraxaci 35 parts, Herba Patriniae 35 parts, Rhizoma Smilacis Glabrae 35 parts, Caulis Sargentodoxae 35 parts, Caulis Spatholobi 35 parts, Cortex Magnoliae Officinalis 8 parts, Agkistrodon SHECAO 35 parts, Rhizoma Polygoni Cuspidati 35 parts.

Herba Taraxaci, Herba Patriniae, Rhizoma Smilacis Glabrae, Caulis Sargentodoxae are pulverized, cross 80 mesh sieves, adds 75% second of four Chinese medicine quality 18 times Alcoholic solution, at 57 DEG C, heated and stirred processes 1.6h, then heated and stirred 4h at 68 DEG C, crosses leaching filtrate.By Caulis Spatholobi, thickness Piao, Herba Hedyotidis Diffusae, Rhizoma Polygoni Cuspidati are pulverized, are crossed 100 mesh sieves, and the citric acid alcoholic solution adding four Chinese medicine quality 8 times extracts 2 times, Fructus Citri Limoniae In acid alcohol solution, the mass content of citric acid is 3-4%, and extraction temperature is 72 DEG C, and extraction time is 3.2h, merges lixiviating solution, dense It is reduced to the 28% of original volume, prepares concentrated solution.Filtrate is mixed with concentrated solution, heated and stirred 50min at 75 DEG C, then carry out Supersound process 35min, obtains Chinese medicine, and wherein ultrasonic power is 800W.

Embodiment 3

In the embodiment of the present invention, the Chinese medicine of a kind of Enem-d treatment gynaecopathia, by following former according to weight portion Material composition: Herba Taraxaci 28 parts, Herba Patriniae 28 parts, Rhizoma Smilacis Glabrae 28 parts, Caulis Sargentodoxae 28 parts, Caulis Spatholobi 28 parts, Cortex Magnoliae Officinalis 5 parts, Agkistrodon SHECAO 28 parts, Rhizoma Polygoni Cuspidati 28 parts.

Herba Taraxaci, Herba Patriniae, Rhizoma Smilacis Glabrae, Caulis Sargentodoxae are pulverized, cross 80 mesh sieves, adds 75% second of four Chinese medicine quality 18 times Alcoholic solution, at 56 DEG C, heated and stirred processes 1.55h, then heated and stirred 3.8h at 66 DEG C, crosses leaching filtrate.By Caulis Spatholobi, Cortex Magnoliae Officinalis, Herba Hedyotidis Diffusae, Rhizoma Polygoni Cuspidati are pulverized, are crossed 100 mesh sieves, and the citric acid alcoholic solution adding four Chinese medicine quality 8 times extracts 2 times, lemon In lemon acid alcohol solution, the mass content of citric acid is 3.5%, and extraction temperature is 71 DEG C, and extraction time is 3.1h, merges lixiviating solution, It is concentrated into the 26% of original volume, prepares concentrated solution.Filtrate is mixed with concentrated solution, heated and stirred 45min at 73 DEG C, then enter Row supersound process 32min, obtains Chinese medicine, and wherein ultrasonic power is 800W.

Embodiment 4

In the embodiment of the present invention, the Chinese medicine of a kind of Enem-d treatment gynaecopathia, by following former according to weight portion Material composition: Herba Taraxaci 32 parts, Herba Patriniae 32 parts, Rhizoma Smilacis Glabrae 32 parts, Caulis Sargentodoxae 32 parts, Caulis Spatholobi 32 parts, Cortex Magnoliae Officinalis 7 parts, Agkistrodon SHECAO 32 parts, Rhizoma Polygoni Cuspidati 32 parts.

Herba Taraxaci, Herba Patriniae, Rhizoma Smilacis Glabrae, Caulis Sargentodoxae are pulverized, cross 80 mesh sieves, adds 75% second of four Chinese medicine quality 18 times Alcoholic solution, at 56 DEG C, heated and stirred processes 1.55h, then heated and stirred 3.8h at 66 DEG C, crosses leaching filtrate.By Caulis Spatholobi, Cortex Magnoliae Officinalis, Herba Hedyotidis Diffusae, Rhizoma Polygoni Cuspidati are pulverized, are crossed 100 mesh sieves, and the citric acid alcoholic solution adding four Chinese medicine quality 8 times extracts 2 times, lemon In lemon acid alcohol solution, the mass content of citric acid is 3.5%, and extraction temperature is 71 DEG C, and extraction time is 3.1h, merges lixiviating solution, It is concentrated into the 26% of original volume, prepares concentrated solution.Filtrate is mixed with concentrated solution, heated and stirred 45min at 73 DEG C, then enter Row supersound process 32min, obtains Chinese medicine, and wherein ultrasonic power is 800W.

Embodiment 5

In the embodiment of the present invention, the Chinese medicine of a kind of Enem-d treatment gynaecopathia, by following former according to weight portion Material composition: Herba Taraxaci 30 parts, Herba Patriniae 30 parts, Rhizoma Smilacis Glabrae 30 parts, Caulis Sargentodoxae 30 parts, Caulis Spatholobi 30 parts, Cortex Magnoliae Officinalis 6 parts, Agkistrodon SHECAO 30 parts, Rhizoma Polygoni Cuspidati 30 parts.

Herba Taraxaci, Herba Patriniae, Rhizoma Smilacis Glabrae, Caulis Sargentodoxae are pulverized, cross 80 mesh sieves, adds 75% second of four Chinese medicine quality 18 times Alcoholic solution, at 56 DEG C, heated and stirred processes 1.55h, then heated and stirred 3.8h at 66 DEG C, crosses leaching filtrate.By Caulis Spatholobi, Cortex Magnoliae Officinalis, Herba Hedyotidis Diffusae, Rhizoma Polygoni Cuspidati are pulverized, are crossed 100 mesh sieves, and the citric acid alcoholic solution adding four Chinese medicine quality 8 times extracts 2 times, lemon In lemon acid alcohol solution, the mass content of citric acid is 3.5%, and extraction temperature is 71 DEG C, and extraction time is 3.1h, merges lixiviating solution, It is concentrated into the 26% of original volume, prepares concentrated solution.Filtrate is mixed with concentrated solution, heated and stirred 45min at 73 DEG C, then enter Row supersound process 32min, obtains Chinese medicine, and wherein ultrasonic power is 800W.

Comparative example 1

In addition to not containing Herba Hedyotidis Diffusae, its formula and preparation process are consistent with embodiment 5.

Comparative example 2

Containing only Herba Hedyotidis Diffusae, its preparation process is consistent with embodiment 5.

Embodiment 6 acute toxicity maximum resistance test

The Chinese medicine that according to embodiments of the present invention prepared by 1-5 carries out acute toxicity maximum resistance test in animal body, right Mouse stomach is administered and 420 times that day maximum tolerated dose is the clinical consumption per day of adult of rectally, does not sees under this dosage The toxic reaction of the Chinese medicine that the preparation method that observing the present invention provides is made.

Embodiment 7 long term toxicity test

The Chinese medicine that according to embodiments of the present invention prepared by 1-5 carries out 6 months long term toxicity tests in animal body, gives every day Rat oral gavage is administered and rectally, and dosage is respectively equivalent to adult 100 times of clinic every day day usage amount, 50 times, 25 times. Observation item is include General observation and the complete detection that includes including hematological examination 29.Result shows, gives medicament for three All there is not obvious adverse reaction in amount, shows that the Chinese medicine that according to embodiments of the present invention prepared by 1-5 is safety for Clinical practice 's.

Embodiment 8 clinical trial

1, physical data

Accept patient's totally 400 example for medical treatment, be all diagnosed as gynaecopathia through gynecologial examination, in its age 18-52 year, be randomly divided into 8 groups, Often organize 50 examples, be respectively treatment 1 group, treat 2 groups, treat 3 groups, treat 4 groups, treat 5 groups and comparison 1 group, compare 2 groups, right According to 3 groups, treatment 1-5 group uses the Chinese medicine of embodiment 1-5, comparison 1-2 group to use the Chinese medicine of comparative example 1-2 respectively respectively, Usage and dosage: Enem-d, once a day, a 1g.Compare 3 groups and take FUKE QIANJIN PIAN, take in strict accordance with description.Respectively The group course of disease of case, degrees of symptoms are basically identical, without significant difference, have comparability.

2, efficacy determination:

(1) cure: gynaecopathia transference cure；

(2) take a turn for the better: basic gynaecopathia transference cure；

(3) invalid: disease is unchanged.

3, therapeutic outcome

Detecting after taking medicine 10 days, result is as shown in table 1.

Table 1

Clinical therapeutic efficacy shows, embodiment of the present invention 1-5 is better than compareing 1-3 group, during embodiment of the present invention 1-5 provides The cure rate of Drug therapy gynaecopathia is more than 74%, and wherein embodiment 3-5 is preferable, cure rate more than 88%, embodiment 5 Optimum, cure rate reaches 100%；Total effective rate is more than 96%.Embodiment 5 is compared with comparative example 1-2, it is known that, the present invention is Effect is played under the synergism of each raw material.

Model case is illustrated:

1: Song, female, 22 years old, suffer from endometritis, accessory installation, lower abdomen dull pain, use the embodiment of the present invention 3 Chinese medicine After thing one week, ultrasound diagnosis is fully recovered.

2: Wang, female, 28 years old, suffer from vaginitis, endometritis, disease sees pus and blood leukorrhagia, and pudendum is swollen itches unbearably, uses this Bright embodiment 5 Chinese medicine, fully recovers after 10 days, follows up a case by regular visits to, without recurrence.

3: Jiang, female, 35 years old, time have lower abdomen pain, urgent micturition, leukorrhagia, fatigue and lack of strength, ultrasound diagnosis suffers from cervicitis, pelvic cavity Hydrops, left ovary volume increases, and takes the recovery from illness in 10 days of the embodiment of the present invention 5 medicine.

It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie In the case of the spirit or essential attributes of the present invention, it is possible to realize the present invention in other specific forms.Therefore, no matter From the point of view of which point, all should regard embodiment as exemplary, and be nonrestrictive, the scope of the present invention is by appended power Profit requires rather than described above limits, it is intended that all by fall in the implication of equivalency and scope of claim Change is included in the present invention.

Although moreover, it will be appreciated that this specification is been described by according to embodiment, but the most each embodiment only wraps Containing an independent technical scheme, this narrating mode of description is only that for clarity sake those skilled in the art should Description can also be formed those skilled in the art through appropriately combined as an entirety, the technical scheme in each embodiment May be appreciated other embodiments.

Claims (5)

1. the Chinese medicine of an Enem-d treatment gynaecopathia, it is characterised in that be made up of according to the raw material of weight portion following: Herba Taraxaci 25-35 part, Herba Patriniae 25-35 part, Rhizoma Smilacis Glabrae 25-35 part, Caulis Sargentodoxae 25-35 part, Caulis Spatholobi 25-35 part, Cortex Magnoliae Officinalis 4-8 Part, Herba Hedyotidis Diffusae 25-35 part, Rhizoma Polygoni Cuspidati 25-35 part.

The Chinese medicine of Enem-d the most according to claim 1 treatment gynaecopathia, it is characterised in that by following according to weight The raw material composition of amount part: Herba Taraxaci 28-32 part, Herba Patriniae 28-32 part, Rhizoma Smilacis Glabrae 28-32 part, Caulis Sargentodoxae 28-32 part, Caulis Spatholobi 28-32 part, Cortex Magnoliae Officinalis 5-7 part, Herba Hedyotidis Diffusae 28-32 part, Rhizoma Polygoni Cuspidati 28-32 part.

The Chinese medicine of Enem-d the most according to claim 1 treatment gynaecopathia, it is characterised in that by following according to weight The raw material composition of amount part: Herba Taraxaci 30 parts, Herba Patriniae 30 parts, Rhizoma Smilacis Glabrae 30 parts, Caulis Sargentodoxae 30 parts, Caulis Spatholobi 30 parts, Cortex Magnoliae Officinalis 6 Part, Herba Hedyotidis Diffusae 30 parts, Rhizoma Polygoni Cuspidati 30 parts.

4. a preparation method for the Chinese medicine of the Enem-d treatment gynaecopathia as described in claim 1-3 is arbitrary, it is special Levy and be, comprise the steps of:

1) Herba Taraxaci, Herba Patriniae, Rhizoma Smilacis Glabrae, Caulis Sargentodoxae are pulverized, cross 80 mesh sieves, add 75% ethanol of four Chinese medicine quality 18 times Solution, at 55-57 DEG C, heated and stirred processes 1.5-1.6h, then heated and stirred 3.5-4h at 65-68 DEG C, crosses leaching filtrate；

2) Caulis Spatholobi, Cortex Magnoliae Officinalis, Herba Hedyotidis Diffusae, Rhizoma Polygoni Cuspidati are pulverized, crossed 100 mesh sieves, add the Fructus Citri Limoniae acid alcohol of four Chinese medicine quality 8 times Solution extracts 2 times, and in citric acid alcoholic solution, the mass content of citric acid is 3-4%, and extraction temperature is 70-72 DEG C, extraction time For 3-3.2h, merge lixiviating solution, be concentrated into the 25-28% of original volume, prepare concentrated solution；

3) filtrate is mixed with concentrated solution, heated and stirred 40-50min at 72-75 DEG C, then carry out supersound process 30- 35min, obtains Chinese medicine, and wherein ultrasonic power is 800W.

5. the application in preparation treatment treatment medicine for gynecopathy of the Chinese medicine as described in claim 1-3 is arbitrary.