CN100368008C - Chinese medicine for treating gynopathy and its preparing process - Google Patents
Chinese medicine for treating gynopathy and its preparing process Download PDFInfo
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- CN100368008C CN100368008C CNB2004100130815A CN200410013081A CN100368008C CN 100368008 C CN100368008 C CN 100368008C CN B2004100130815 A CNB2004100130815 A CN B2004100130815A CN 200410013081 A CN200410013081 A CN 200410013081A CN 100368008 C CN100368008 C CN 100368008C
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Abstract
The present invention relates to a traditional Chinese medicine for treating gynopathy and a preparation technology thereof. The traditional Chinese medicine for treating gynopathy is a medicinal preparation which is prepared from the raw materials of the following proportion by weight: 260 parts of tree peony bark, 260 parts of honeysuckle flower, 220 parts of red peony root, 160 parts of zedoray rhizome, 200 parts of corydalis tuber(processed with vinegar), 200 parts of patrinia, 200 parts of sargentgloryvine, 160 parts of peach seed, 160 parts of angelica, 160 parts of myrrh, 160 parts of cassia twig, 160 parts of nutgrass galingale rhizome and 260 parts of coix seed. All the medicines are compounded together, warming and clearing are used simultaneously, and reinforcing and reducing methods are adopted simultaneously, so that the traditional Chinese medicine for treating gynopathy has the functions of simultaneously regulating Qi circulation and blood circulation, activating blood circulation to dissipate blood stasis without injuring the blood, clearing away heat and toxic materials without leaving blood stasis, and enabling the blood to run with the Qi, thereby removing blood stasis, clearing heat toxin, dredging Qi and blood circulation, and healing various diseases. The traditional Chinese medicine for treating gynopathy is an effective prescription for treating chronic pelvic inflammation caused by Qi stagnation and blood stasis, and internal heat toxin.
Description
Technical field
The present invention relates to a kind of Chinese medicine and preparation technology thereof who treats gynaecopathia.
Background technology
Chronic pelvic inflammatory disease is gynecological clinic commonly encountered diseases, frequently-occurring disease, and sickness rate raises year by year, brings serious harm for body of women health.Chronic pelvic inflammatory disease is meant the chronic inflammatory disease of internal reproductive organ, comprises the chronic inflammatory disease and the chronic pelvic paramitritis of uterus, fallopian tube and ovary.Often to fail thoroughly treatment or patient's body constitution relatively poor because of acute pelvic inflammatory disease for chronic pelvic inflammatory disease, due to the course of disease delay.Motherland's medical science thinks that it mainly is because through row puerperal, the vessels of the uterus inanition, damp and hot heresy is taken advantage of a weak point, or unclean because of health preserving, infects evil poison, accumulates and heat-transformation, injure appoint, superintend and direct, dai channel, the turbid damp pyretic toxicity is accumulated the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, the visitor goes among the born of the same parents and fights mutually with QI and blood, thereby falls ill.The Chinese medicine of traditional treatment chronic pelvic inflammatory disease mostly is the prescription that prescription handed down from one's ancestors among the people or hospital dispose voluntarily, but Cortex Moutan is not arranged as yet, and Flos Lonicerae is the Chinese medicine of the treatment chronic pelvic inflammatory disease of monarch drug.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine and preparation technology thereof who treats gynaecopathia.
Technical scheme of the present invention is:
A kind of Chinese medicine for the treatment of gynaecopathia, it is to be by the medicament that the following weight proportion raw material is made: Cortex Moutan 200-300 part, Flos Lonicerae 200-300 part.
The Chinese medicine of treatment gynaecopathia also contains the medicament that the following weight proportion raw material is made: Herba Patriniae 180-220 part.
The Chinese medicine of treatment gynaecopathia also contains the medicament that the following weight proportion raw material is made: Rhizoma Corydalis 180-220 part.
The Chinese medicine of treatment gynaecopathia also contains the medicament that the following weight proportion raw material is made: Caulis Sargentodoxae 180-220 part.
The Chinese medicine of treatment gynaecopathia also contains the medicament that the following weight proportion raw material is made: Radix Paeoniae Rubra 180-240 part, Rhizoma Curcumae 130-200 part.
The Chinese medicine of treatment gynaecopathia also contains the medicament that the following weight proportion raw material is made: Semen Persicae 130-200 part, Radix Angelicae Sinensis 130-200 part, Myrrha 130-200 part, Ramulus Cinnamomi 130-200 part, Rhizoma Cyperi 130-200 part, Semen Coicis 200-300 part.
The Chinese medicine of treatment gynaecopathia contains the medicament that the following weight proportion raw material is made: 260 parts of Cortex Moutans, 260 parts of Flos Loniceraes, 220 parts of Radix Paeoniae Rubra, 160 parts of Rhizoma Curcumae, 200 parts of Rhizoma Corydalis (vinegar system), 200 parts of Herba Patriniae, 200 parts of Caulis Sargentodoxae, 160 parts in Semen Persicae, 160 parts of Radix Angelicae Sinensis, 160 parts of Myrrha (processed), 160 parts of Ramulus Cinnamomi, 160 parts of Rhizoma Cyperis, 260 parts of Semen Coiciss.
The preparation technology of the Chinese medicine of treatment gynaecopathia, it is characterized in that by following step: above 13 flavors, Rhizoma Corydalis is ground into coarse powder, added 60% soak with ethanol 24 hours, reflux, extract, three times, each 1-2 hour, merge three times extracting solution, filter decompression recycling ethanol, and the thick paste that to be concentrated into 60 ℃ of relative densities be 1.30-1.35; Cortex Moutan distillation extraction paeonol, paeonol beta-schardinger dextrin-inclusion, the aqueous solution after distillation device is in addition collected; The five tastes such as Ramulus Cinnamomi, Rhizoma Curcumae, Myrrha, Rhizoma Cyperi, Radix Angelicae Sinensis extract volatile oil, volatile oil beta-schardinger dextrin-inclusion, and the aqueous solution after distillation device is in addition collected; Ramulus Cinnamomi, Rhizoma Curcumae, Myrrha, Rhizoma Cyperi, Cortex Moutan medicinal residues and all the other Flos Loniceraes after the five tastes such as Radix Angelicae Sinensis extract the medicinal residues behind the volatile oil and carry paeonol, Radix Paeoniae Rubra, Semen Persicae, Herba Patriniae, Caulis Sargentodoxae, Six-elements such as Semen Coicis decoct with water 2 times, each 1-2 hour, collecting decoction, filter, filtrate and above-mentioned other aqueous solutions merge, the concentrated solution that to be concentrated into 60 ℃ of relative densities be 1.08-1.10, add ethanol and make precipitation, leave standstill, getting the supernatant decompression recycling ethanol and being concentrated into 60 ℃ of relative densities is 1.30～1.35 thick paste, and above-mentioned all thick pastes are merged, add an amount of sucrose, dextrin, in 60-70 ℃ of vacuum drying, the pure one-tenth of powder fine powder is made granule, dry, add the inclusion complex of above-mentioned all volatile oil, mixing makes granule.
The invention has the advantages that: have the present invention of experimental data proof that better therapeutic effect is arranged, the present invention establishes with blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, and promoting the circulation of QI to relieve pain are main. and cure mainly chronic pelvic inflammation and belong to qi depression to blood stasis, or the person of accumulateing in the double pyretic toxicity.
Chronic pelvic inflammatory disease belongs to categories such as motherland's medical science leukorrhagia, lower abdominal pain, pox abdominal mass, and its cause of disease is how relevant with bacterial infection.Pathology mainly is hypertrophy, adhesion, and with the chronic inflammation cellular infiltration.Pathogenesis is many, and love is not for a long time gone with evil poison dipping, qi depression to blood stasis, and retention of damp-heat in the interior is main, then causes Chong and Ren channel disorder for a long time.
At qi depression to blood stasis, the pathogenic characteristic that accumulates in the pyretic toxicity is according to " element ask the most pure virginity will discuss greatly ": " promoting circulation of QI-blood; make its accent reach, and it is flat to make peace ", " hard masses should be resolved gradually ", " disease with retention of pathogen in the body should be treated by elimination therapy ", " sluggishness of QI and blood should be treated by activation ", " principle for the treatment of heat syndrome with cold-natured drugs; thirty years of age blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, the method for promoting the circulation of QI to relieve pain; stagnant heat is also controlled; stagnation of QI clots absorbing blood is dispelled, and pyretic toxicity is clear, and all diseases can be healed.
Cortex Moutan hardship, suffering, be slightly cold, go into the heart, liver, kidney channel, this product delicate fragrance reaches thoroughly, can go into the serum transconversion into heat and stagnate, the kind again clear saturating cloudy volt fire that divides, the good merchantable brand commonly used that the stagnant heat card is arranged for blood system: the Flos Lonicerae sweet in the mouth is cold in nature, go into the heart, lung, stomach warp, this product fragrance reaches does not thoroughly then hold back heresy, kind removing summer-heat noxious heat in the blood system, accumulate pain infections toxic swelling key medicine commonly used for controlling in the pyretic toxicity.More than two medicines be harmonious, the stasis of blood in the blood that both looses stagnates, the pyretic toxicity of branchs that purify the blood again, blood circulation promoting and blood stasis dispelling and not absurd row, heat-clearing and toxic substances removing does not stay the stasis of blood again, stagnant heat is also controlled, and is monarch drug in square altogether.
Radix Paeoniae Rubra bitter in the mouth cold nature is gone into liver, spleen channel, effect clearing away heat and cooling blood, stasis-dispelling and pain-killing, match with Cortex Moutan, the power of the worn-out stasis of blood of removing heat from blood wins especially: Rhizoma Curcumae acrid in the mouth bitterness temperature, go into liver, spleen channel, and the hot hardship of loosing of this product is let out, temperature is current to stagnate, the function removing blood stasis, promoting the circulation of QI to relieve pain, the blood in the kind especially dispelling the stagnated QI, the women's Qi stagnation blood stasis, it is the most suitable that amenorrhea stomachache is used; Rhizoma Corydalis acrid in the mouth, bitterness temperature are gone into liver, the heart, spleen channel, this crystalline substance is the gas in the promoting the circulation of blood both, blood in the circulation of qi promoting again so be the good medicine of the promoting the circulation of QI pain relieving of invigorating blood circulation, matches with Radix Paeoniae Rubra, Rhizoma Curcumae, QI and blood is also controlled, make the stasis of blood gas of dispelling smooth, the smooth blood of gas is capable, and to increase the merit of Cortex Moutan promoting blood circulation, removing blood stasis and relieving pain: Herba Patriniae acrid in the mouth, bitterness are slightly cold, go into stomach, large intestine, Liver Channel, the kind heat-clearing and toxic substances removing of merit disappears bitterly; The Caulis Sargentodoxae bitter in the mouth is flat, goes into large intestine channel, heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, and two medicines share and focus on heat clearing away and separate, again can blood circulation promoting and blood stasis dispelling.More than all medicines match, stagnant heat is also controlled, the QI and blood people having the same aspiration and interest, principal drug assistance blood circulation promoting and blood stasis dispelling altogether, the worker of heat-clearing and toxic substances removing, and be ministerial drug.
The Myrrha acrid in the mouth is flat, goes into conscience, spleen channel, the fragrant benefaction of this product gas, the bitter in the mouth using pungent drugs for dispersion and bitter drugs for purgation, for clots absorbing loose blood and relieving pain will product; Semen Persicae bitter in the mouth, Gan Xingping go into the heart, liver, large intestine channel, blood circulation promoting and blood stasis dispelling, eliminating mass pain relieving; Radix Angelicae Sinensis sweet in the mouth, suffering, bitterness temperature are gone into liver, the heart, spleen channel, and this product can be enriched blood and can be invigorated blood circulation, and hold concurrently can promoting the circulation of QI to relieve pain, match with drug for invigorating blood circulation and eliminating stasis in the side, and there have blood stasis dispelling not hinder to be just wonderful; Ramulus Cinnamomi acrid in the mouth, sweet warm in nature is gone into lung, the heart, urinary bladder channel, warm arteries and veins removing blood stasis, and this product suffering is loose warm logical, can rouse oneself QI and blood, promoting blood circulation, both the power of the capable blood stasis dispelling that stagnates of blood circulation promoting medicine in the side of helping prevents that again the fraud of staying the stasis of blood is held back in the product cold of bitter cold; Rhizoma Cyperi acrid-sweet flavor, little bitterness are put down, and go into liver, tri-jiao channel, coloured glaze liver and qi, menstruction regulating and pain relieving.All medicines share reinforcing and reducing concurrently, and residence is supported in living, and blood stasis dispelling is not just being hindered, and the QI and blood well is controlled, and the capable then blood of gas is capable, and the capable then stasis of blood of blood is dispelled, and to help the power of monarch-minister drug promoting blood circulation, removing blood stasis and relieving pain, is adjuvant drug altogether.
Semen Coicis sweet in the mouth, light cold nature are gone into spleen, stomach, kidney channel, sweet light being slightly cold of this product, and eliminating dampness by diuresis diarrhea of heat type urine can draw that damp and hot evil poison is descending, and sweet in the mouth is slow, again can invigorating spleen and reinforcing stomach, coordinating the actions of various ingredients in a prescription is with being messenger drug.
All medicine compatibilities, clear Wen Bingyong reinforcing and reducing concurrently, the QI and blood people having the same aspiration and interest, blood circulation promoting and blood stasis dispelling is blood trouble not, and heat-clearing and toxic substances removing does not stay the stasis of blood, and the capable then blood of gas is capable, and blood stasis must be dispelled, and pyretic toxicity gets clearly, and QI and blood is unobstructed, and all diseases can be healed.Really be treatment chronic pelvic inflammatory disease card genus qi depression to blood stasis, the good recipe of accumulateing in the pyretic toxicity of holding concurrently.
The scorching peaceful granule therapy chronic pelvic inflammatory disease 60 routine clinical observations of Jindan woman:
We select scorching peaceful granule therapy chronic pelvic inflammatory disease patient 60 examples of Jindan woman of embodiments of the invention 9 gained for use year August in October, 1998 to 1999, now clinical treatment observation are reported as follows:
Physical data
60 examples are clinic case and account for 70%.The course of disease is the longest 23 years, and at minimum 23 years old of age, maximum 45 years old, the example member was short 3 months in wherein 25 years old～35 years old 42.Wherein merge hysteromyoma 2 examples.
Diagnosis basis:
Tcm diagnosis, dialectical standard and foundation thereof:
Syndrome of qi stagnation and blood stasis, or accumulate card in the double pyretic toxicity: disease is abdomen and the bloated pain of waist sacrum bob as follows, or ache, menstrual period or tired back sx, and profuse leukorrhea, yellow skin or white, or HUANGBAI(sic) is double mutually, or the matter thickness, or abnormal smells from the patient is smelt as of rotten fish red tongue greasy fur little Huang, stringy and hesitant pulse or number.
Western medicine diagnose standard and foundation thereof:
New Chinese medicine treatment " the clinical research guideline of female genital disease " chronic pelvic inflammatory disease part according to the Ministry of Public Health promulgation.
1. symptom: lower abdomen and lumbago, lower abdomen are weighed down and are expanded, and lumbosacral region is ached, and increase the weight of after the fatigue of being everlasting, the sexual intercourse, during defecation, and increase the weight of before and after the menstruation.Can be with low grade fever, menstruation increases band and increases.
2. gynecologial examination: the uterus often is the position, back, the active receiving restriction, or adhesion is fixed.Can touch streak thing in the one or both sides, uterus during the fallopian tube inflammation, and mild tenderness is arranged; During the inflammation of pelvic cavity connective tissue, the one or both sides, uterus have that lamellar thickens, tenderness, or touch enclosed mass in the pelvic cavity one or both sides.
3. standards of grading
Uterine activity is limited, tenderness 5 minutes
That fallopian tube is is streak, tenderness 5 minutes
One or both sides, uterus lamellar thickens 5 fens
The lower abdomen waist is ached and was dropped 3 fens
Leukorrhagia increased 1 fen
Low grade fever 1 minute
Menstrual period, lower abdominal pain was 1 minute
The every increase of the course of disease added 0.5 fen in 1 year
Above iterated integral is a severe 15 fens above persons; 10-14 is divided into moderate; 5～9 are divided into slightly.
Therapeutic Method
1. square medicine is formed: basic side forms: Cortex Moutan, Flos Lonicerae, Radix Paeoniae Rubra, Rhizoma Curcumae, Rhizoma Corydalis, Herba Patriniae, Caulis Sargentodoxae, Myrrha, Semen Persicae, Radix Angelicae Sinensis, Ramulus Cinnamomi, Rhizoma Cyperi, Semen Coicis.
2. method of administration: the scorching peaceful granule of oral woman, each 1 bag, every bag 15 grams, every day 3 times.
3. take medicine the course of treatment: 4 weeks of taking medicine are a course of treatment, and the patient with severe symptoms can obey for 2～3 courses of treatment, finish the back course of treatment and observe the summary curative effect.
Criterion of therapeutical effect and foundation thereof.
The clinical research guideline of female genital disease " new Chinese medicine treatment " chronic pelvic inflammatory disease curative effect determinate standard of issuing by Ministry of Public Health.
Recovery from illness: symptom, sign and inspection all recover normal, and integration is 0 minute.
Produce effects: transference cure, gynecologial examination has clear improvement, and the treatment back reduces more than 2/3 than the preceding integration of treatment.
Effectively: symptom, sign and check all to have and alleviate, treatment back than treatment before integration reduction by 1/3.
Invalid: the treatment back does not have improvement.
Therapeutic effect:
The present invention is through clinical treatment chronic pelvic inflammatory disease patient 60 examples, total effective 57 examples, and total effective rate is 95%, wherein cures 42 examples, cure rate is 70%; Produce effects 10 examples, obvious effective rate 16.6%; Effective 5 examples, effective percentage are 8.3%; Invalid 3 examples, inefficiency are 5%.Wherein 18 routine patients carry out blood, urine, stool routine examination and hepatic and renal function inspection, all no abnormal change before and after medication.Before and after taking medicine, 10 routine patients carry out B-type ultrasonography, fallopian tube obscurity boundary before wherein 8 routine patients take medicine, and the iconography of internal diameter broadening changes, and recovers normal in the back of taking medicine.This medicine has no side effect after clinical 60 routine patients take medicine, and slight stomach discomfort is arranged after individual patients is taken, but take after the meal or drug withdrawal after can alleviate.This pharmaceutically dosage form is a granule, and taking convenience is welcome by patient deeply.
Model case
Wu so-and-so, 25 years old, the teacher, the main suit lower abdomen weighs down pain and accompanies waist sacrum miserable half a year, menstrual period or tired postemphasis companion profuse leukorrhea, yellow skin, matter thickness, dimly red tongue, the little Huang of tongue, wiry and frequent pulse.Gynecologial examination uterus normal size, position, back, limitation of activity, tenderness, the bilateral adnexa thickens, tenderness, examination per vagina leucorrhea amount is many, is faint yellow.Ultrasound diagnosis bilateral fallopian tube is fuzzy, and broadening reaches more than the 0.5cm.Promptly give clothes Jindan woman scorching peaceful granule, each 1 bag, serve on for 4 weeks at every day 3 times.Patient takes recurrence due to taking drug and examines, and tells lower abdomen and weighs down pain, the miserable transference cure of waist sacrum, and leucorrhea is measured less, color is white, it is light red to look into body of the tongue, and tongue is white, stringy and thready pulse.Gynecologial examination uterus tenderness disappears, and can reset is anteposition, and the bilateral adnexa thickens, and tenderness all disappears.Ultrasound diagnosis bilateral fallopian tube is more clear, internal diameter＜5cm.
The specific embodiment
Embodiment 1
The Chinese medicine of treatment gynaecopathia, it is the medicament of being made by the following weight proportion raw material: Cortex Moutan 200-300 part, Flos Lonicerae 200-300 part.
Embodiment 2
The Chinese medicine of treatment gynaecopathia, it is the medicament of being made by the following weight proportion raw material: Cortex Moutan 200-300 part, Flos Lonicerae 200-300 part, Herba Patriniae 180-220 part.
Embodiment 3
The Chinese medicine of treatment gynaecopathia, it is the medicament of being made by the following weight proportion raw material: Cortex Moutan 200-300 part, Flos Lonicerae 200-300 part, Herba Patriniae 180-220 part, Rhizoma Corydalis 180-220 part.
Embodiment 4
The Chinese medicine of treatment gynaecopathia, it is the medicament of being made by the following weight proportion raw material: Cortex Moutan 200-300 part, Flos Lonicerae 200-300 part, Herba Patriniae 180-220 part, Rhizoma Corydalis 180-220 part, Caulis Sargentodoxae 180-220 part.
Embodiment 5
The Chinese medicine of treatment gynaecopathia, it is the medicament of being made by the following weight proportion raw material: Cortex Moutan 200-300 part, Flos Lonicerae 200-300 part, Herba Patriniae 180-220 part, Rhizoma Corydalis 180-220 part, Caulis Sargentodoxae 180-220 part, Radix Paeoniae Rubra 180-240 part, Rhizoma Curcumae 130-200 part.
Embodiment 6
The Chinese medicine of treatment gynaecopathia, it is the medicament of being made by the following weight proportion raw material: Cortex Moutan 200-300 part, Flos Lonicerae 200-300 part, Herba Patriniae 180-220 part, Rhizoma Corydalis 180-220 part, Caulis Sargentodoxae 180-220 part, Radix Paeoniae Rubra 180-240 part, Rhizoma Curcumae 130-200 part, Semen Persicae 130-200 part, Radix Angelicae Sinensis 130-200 part, Myrrha 130-200 part, Ramulus Cinnamomi 130-200 part, Rhizoma Cyperi 130-200 part, Semen Coicis 200-300 part.
Embodiment 7
The Chinese medicine of treatment gynaecopathia contains the medicament that the following weight proportion raw material is made: 260 parts of Cortex Moutans, 260 parts of Flos Loniceraes, 220 parts of Radix Paeoniae Rubra, 160 parts of Rhizoma Curcumae, 200 parts of Rhizoma Corydalis (vinegar system), 200 parts of Herba Patriniae, 200 parts of Caulis Sargentodoxae, 160 parts in Semen Persicae, 160 parts of Radix Angelicae Sinensis, 160 parts of Myrrha (processed), 160 parts of Ramulus Cinnamomi, 160 parts of Rhizoma Cyperis, 260 parts of Semen Coiciss.
The preparation technology of the Chinese medicine of treatment gynaecopathia, press following step: above 13 flavors, Rhizoma Corydalis is ground into coarse powder, added 60% soak with ethanol 24 hours, reflux, extract, three times, each 1-2 hour, merge three times extracting solution, filter decompression recycling ethanol, and the thick paste that to be concentrated into 60 ℃ of relative densities be 1.30-1.35; Cortex Moutan distillation extraction paeonol, paeonol beta-schardinger dextrin-inclusion, the aqueous solution after distillation device is in addition collected; The five tastes such as Ramulus Cinnamomi, Rhizoma Curcumae, Myrrha, Rhizoma Cyperi, Radix Angelicae Sinensis extract volatile oil, volatile oil beta-schardinger dextrin-inclusion, and the aqueous solution after distillation device is in addition collected; Ramulus Cinnamomi, Rhizoma Curcumae, Myrrha, Rhizoma Cyperi, Cortex Moutan medicinal residues and all the other Flos Loniceraes after the five tastes such as Radix Angelicae Sinensis extract the medicinal residues behind the volatile oil and carry paeonol, Radix Paeoniae Rubra, Semen Persicae, Herba Patriniae, Caulis Sargentodoxae, Six-elements such as Semen Coicis decoct with water 2 times, each 1-2 hour, collecting decoction, filter, filtrate and above-mentioned other aqueous solutions merge, the concentrated solution that to be concentrated into 60 ℃ of relative densities be 1.08-1.10, add ethanol and make precipitation, leave standstill, getting the supernatant decompression recycling ethanol and being concentrated into 60 ℃ of relative densities is 1.30～1.35 thick paste, and above-mentioned all thick pastes are merged, add an amount of sucrose, dextrin, in 60-70 ℃ of vacuum drying, the pure one-tenth of powder fine powder is made granule, dry, add the inclusion complex of above-mentioned all volatile oil, mixing makes granule.
Embodiment 8
The Chinese medicine of treatment gynaecopathia contains the medicament that the following weight proportion raw material is made: 260 parts of Cortex Moutans, 260 parts of Flos Loniceraes, 220 parts of Radix Paeoniae Rubra, 160 parts of Rhizoma Curcumae, 200 parts of Rhizoma Corydalis (vinegar system), 200 parts of Herba Patriniae, 200 parts of Caulis Sargentodoxae, 160 parts in Semen Persicae, 160 parts of Radix Angelicae Sinensis, 160 parts of Myrrha (processed), 160 parts of Ramulus Cinnamomi, 160 parts of Rhizoma Cyperis, 260 parts of Semen Coiciss.
The preparation technology of the Chinese medicine of treatment gynaecopathia, press following step: above 13 flavors, Rhizoma Corydalis is ground into coarse powder, 60% soak with ethanol that adding 6-8 doubly measures 24 hours, reflux, extract, three times, 2 hours for the first time, 2 hours for the second time, 1 hour for the third time, merge three times extracting solution, filter decompression recycling ethanol, and the thick paste that to be concentrated into 60 ℃ of relative densities be 1.30-1.35; Cortex Moutan distillation extraction paeonol, paeonol beta-schardinger dextrin-inclusion, the aqueous solution after distillation device is in addition collected; The five tastes such as Ramulus Cinnamomi, Rhizoma Curcumae, Myrrha, Rhizoma Cyperi, Radix Angelicae Sinensis extract volatile oil, volatile oil beta-schardinger dextrin-inclusion, and the aqueous solution after distillation device is in addition collected; Ramulus Cinnamomi, Rhizoma Curcumae, Myrrha, Rhizoma Cyperi, Cortex Moutan medicinal residues and all the other Flos Loniceraes after the five tastes such as Radix Angelicae Sinensis extract the medicinal residues behind the volatile oil and carry paeonol, Radix Paeoniae Rubra, Semen Persicae, Herba Patriniae, Caulis Sargentodoxae, Six-elements such as Semen Coicis add 8-10 decocting doubly and boil 2 times, each 2 hours, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, the concentrated solution that to be concentrated into 60 ℃ of relative densities be 1.08-1.10, add equivalent 95% ethanol and make precipitation, left standstill 48 hours, getting the supernatant decompression recycling ethanol and being concentrated into 60 ℃ of relative densities is 1.30～1.35 thick paste, and above-mentioned all thick pastes are merged, add an amount of sucrose, dextrin, in 60-70 ℃ of vacuum drying, the pure one-tenth of powder fine powder is made granule, dry, add the inclusion complex of above-mentioned all volatile oil, mixing makes granule.
Embodiment 9
The Chinese medicine of treatment gynaecopathia contains the medicament that the following weight proportion raw material is made: 260 parts of Cortex Moutans, 260 parts of Flos Loniceraes, 220 parts of Radix Paeoniae Rubra, 160 parts of Rhizoma Curcumae, 200 parts of Rhizoma Corydalis (vinegar system), 200 parts of Herba Patriniae, 200 parts of Caulis Sargentodoxae, 160 parts in Semen Persicae, 160 parts of Radix Angelicae Sinensis, 160 parts of Myrrha (processed), 160 parts of Ramulus Cinnamomi, 160 parts of Rhizoma Cyperis, 260 parts of Semen Coiciss.
The preparation technology of the Chinese medicine of treatment gynaecopathia, press following step: the extraction of (one) medicine, the extraction of alcohol extraction medicine: it is standby that Rhizoma Corydalis is ground into coarse powder, take by weighing 60% ethanol of 8 times of amounts of fumitory coarse powder adding, soaked 24 hours, reflux 2 hours, filter, 60% alcohol heating reflux 2 hours that adds 6 times of amounts again filters, and adds 60% alcohol heating reflux 1 hour of 6 times of amounts again, filter, merge three times ethanol extract, decompression recycling ethanol also is condensed into the thick paste of relative density 1.30-1.35, is standby Rhizoma Corydalis alcohol extraction cream; Contain the extraction of volatile oil medicine: take by weighing Ramulus Cinnamomi, Rhizoma Curcumae, Myrrha, Rhizoma Cyperi, Radix Angelicae Sinensis 5 herbal medicines, add 5 times of water gagings, extract volatile oil to most, about 6 hours, collect volatile oil, put cold place and preserve, be standby volatile oil; Aqueous solution after distillation device is in addition collected, and is incorporated in the decocting liquid to concentrate, and medicinal residues are incorporated in the water decoction-alcohol sedimentation medicine and decoct; The extraction of Cortex Moutan: take by weighing the Cortex Moutan of recipe quantity, add 6 times of water gagings, distill out paeonol, about 6 hours of time, after the drying, airtight preservation is standby paeonol.Aqueous solution after distillation device is in addition collected, and is incorporated in the decocting liquid to concentrate, and medicinal residues are incorporated in the water decoction-alcohol sedimentation medicine and decoct; The extraction of water decoction-alcohol sedimentation medicine: the decocting of (1) medicine: the medicinal residues after taking by weighing the medicinal residues behind Flos Lonicerae, Radix Paeoniae Rubra, Semen Persicae, Herba Patriniae, Caulis Sargentodoxae, Semen Coicis and the extraction volatile oil of recipe quantity and extracting paeonol merge, decoct 2 times, the water that adds for the first time 10 times of amounts, add for the second time 8 times of water gagings, each 2 hours, collecting decoction is concentrated into 60 ℃ of relative density 1.08-1.10, is standby water drug-decocting concentrating liquid; (2) precipitate with ethanol: with above standby water drug-decocting concentrating liquid, put cold, under fully stirring, slowly add 1 times of amount 95% ethanol, add the back and continue to stir 15-20 minute, staticly settled 48 hours, filter, decompression filtrate recycling ethanol also is condensed into the thick paste of 60 ℃ of relative density 1.30-1.35, is standby water decoction-alcohol sedimentation condensed cream; (2) preparation of the mixing of thick paste and dried cream powder mixes standby Rhizoma Corydalis alcohol extraction cream with standby water decoction-alcohol sedimentation condensed cream, in clear paste: sucrose: dextrin=1: 0: 6: 0.5 ratio adds adjuvant, mixing, in 60-70 ℃ of vacuum drying, pulverize, be standby thousand cream powder; (3) preparation of β-CD inclusion complex: the preparation of volatile oil beta-CD inclusion complex: take by weighing the β-CD that is equivalent to 9 times of amounts of standby volatile oil, in β-CD: the ratio of water=1: 20 adds entry, slight fever makes dissolving, drip volatile oil, stirred 3 hours, put 0-4 ℃ and left standstill 24 hours at 30 ℃, sucking filtration, 40 ℃ of oven dry grind, and are standby; The preparation of paeonol β-CD inclusion complex: get standby paeonol, add an amount of dehydrated alcohol and make dissolving, standby.Take by weighing the β-CD that is equivalent to 12 times of amounts of standby paeonol again, after the water of β-CD and 2 times of amounts is ground well, drip the alcoholic solution of paeonol, fully be ground to into pastel, 40 ℃ dry by the fire in, grind, standby; (4) mixing of medicated powder and particulate preparation: with the alcohol granulation of standby dried cream fine powder with suitable concentration, oven dry, granulate, with volatile oil beta-CD inclusion complex, paeonol β-CD inclusion complex mix homogeneously, packing, promptly.
Embodiment 10
The Chinese medicine of one group of treatment gynaecopathia, it is the medicament of being made by the following weight proportion raw material: 200 parts of Cortex Moutans, 300 parts of Flos Loniceraes.The method that provides by embodiment 7 prepares.
Embodiment 11
The Chinese medicine of one group of treatment gynaecopathia, it is the medicament of being made by the following weight proportion raw material: 200 parts of Cortex Moutans, 200 parts of Flos Loniceraes, 180 parts of Herba Patriniae, 180 parts of Rhizoma Corydalis, 180 parts of Caulis Sargentodoxae, Radix Paeoniae Rubra 180,130 parts of Rhizoma Curcumae, 200 parts in Semen Persicae, 200 parts of Radix Angelicae Sinensis, 200 parts of Myrrhas, 200 parts of Ramulus Cinnamomi, 200 parts of Rhizoma Cyperis, 300 parts of Semen Coiciss.The method that provides by embodiment 8 prepares.
Embodiment 12
The Chinese medicine of one group of treatment gynaecopathia, it is the medicament of being made by the following weight proportion raw material: 300 parts of Cortex Moutans, 300 parts of Flos Loniceraes, 220 parts of Herba Patriniae, 220 parts of Rhizoma Corydalis, 220 parts of Caulis Sargentodoxae, 240 parts of Radix Paeoniae Rubra, 200 parts of Rhizoma Curcumae, 130 parts in Semen Persicae, 130 parts of Radix Angelicae Sinensis, 130 parts of Myrrhas, 130 parts of Ramulus Cinnamomi, 130 parts of Rhizoma Cyperis, 200 parts of Semen Coiciss.The method that provides by embodiment 9 prepares.
Embodiment 13
The Chinese medicine of one group of treatment gynaecopathia, it is the medicament of being made by the following weight proportion raw material: 300 parts of Cortex Moutans, 200 parts of Flos Loniceraes.The method that provides by embodiment 8 prepares.Present embodiment gained medicament is through clinical treatment chronic pelvic inflammatory disease patient 9 examples, total effective 6 examples, and total effective rate is 66.7%, wherein cures 3 examples, cure rate is 33.3%; Produce effects 3 examples, obvious effective rate 33.3%; Effective 0 example, effective percentage are 0%; Invalid 3 examples, inefficiency are 33.3%.
Embodiment 14
The Chinese medicine of one group of treatment gynaecopathia, it is the medicament of being made by the following weight proportion raw material: 240 parts of Cortex Moutans, 260 parts of Flos Loniceraes.The method that provides by embodiment 8 prepares.Present embodiment gained medicament is through clinical treatment chronic pelvic inflammatory disease patient 12 examples, total effective 7 examples, and total effective rate is 58.3%, wherein cures 3 examples, cure rate is 25%; Produce effects 3 examples, obvious effective rate 25%; Effective 1 example, effective percentage are 8.3%; Invalid 5 examples, inefficiency are 41.7%.
Claims (4)
1. Chinese medicine for the treatment of gynaecopathia is characterized in that it is made by 13 flavor raw materials, and described crude drug and weight proportion thereof are: Cortex Moutan 200-300 part, Flos Lonicerae 200-300 part, Herba Patriniae 180-220 part, Rhizoma Corydalis 180-220 part, Caulis Sargentodoxae 180-220 part, Radix Paeoniae Rubra 180-240 part, Rhizoma Curcumae 130-200 part, Semen Persicae 130-200 part, Radix Angelicae Sinensis 130-200 part, Myrrha 130-200 part, Ramulus Cinnamomi 130-200 part, Rhizoma Cyperi 130-200 part, Semen Coicis 200-300 part.
2. the preparation technology of the Chinese medicine of the described treatment gynaecopathia of claim 1, it is characterized in that by following step: Rhizoma Corydalis is ground into coarse powder, added 60% soak with ethanol 24 hours, reflux, extract, three times, each 1-2 hour, merge three times extracting solution, filter, decompression recycling ethanol, and the thick paste that to be concentrated into 60 ℃ of relative densities be 1.30-1.35; Cortex Moutan distillation extraction paeonol, paeonol beta-schardinger dextrin-inclusion, the aqueous solution after distillation device is in addition collected; Ramulus Cinnamomi, Rhizoma Curcumae, Myrrha, Rhizoma Cyperi, the Radix Angelicae Sinensis five tastes extract volatile oil, volatile oil beta-schardinger dextrin-inclusion, and the aqueous solution after distillation device is in addition collected; Ramulus Cinnamomi, Rhizoma Curcumae, Myrrha, Rhizoma Cyperi, Cortex Moutan medicinal residues and all the other Flos Loniceraes after the Radix Angelicae Sinensis five tastes extract the medicinal residues behind the volatile oil and carry paeonol, Radix Paeoniae Rubra, Semen Persicae, Herba Patriniae, Caulis Sargentodoxae, the Semen Coicis Six-element decocts with water 2 times, each 1-2 hour, collecting decoction, filter, filtrate and above-mentioned other aqueous solutions merge, the concentrated solution that to be concentrated into 60 ℃ of relative densities be 1.08-1.10, add ethanol and make precipitation, leave standstill, getting the supernatant decompression recycling ethanol and being concentrated into 60 ℃ of relative densities is 1.30～1.35 thick paste, and above-mentioned all thick pastes are merged, add an amount of sucrose, dextrin, in 60-70 ℃ of vacuum drying, the pure one-tenth of powder fine powder is made granule, dry, add the inclusion complex of above-mentioned all volatile oil, mixing makes granule.
3. the preparation technology of the Chinese medicine of the described treatment gynaecopathia of claim 1, it is characterized in that by following step: Rhizoma Corydalis is ground into coarse powder, 60% soak with ethanol that adding 6-8 doubly measures 24 hours, reflux, extract, three times, 2 hours for the first time, 2 hours for the second time, 1 hour for the third time, merge three times extracting solution, filter, decompression recycling ethanol, and the thick paste that to be concentrated into 60 ℃ of relative densities be 1.30-1.35; Cortex Moutan distillation extraction paeonol, paeonol beta-schardinger dextrin-inclusion, the aqueous solution after distillation device is in addition collected; Ramulus Cinnamomi, Rhizoma Curcumae, Myrrha, Rhizoma Cyperi, the Radix Angelicae Sinensis five tastes extract volatile oil, volatile oil beta-schardinger dextrin-inclusion, and the aqueous solution after distillation device is in addition collected; Ramulus Cinnamomi, Rhizoma Curcumae, Myrrha, Rhizoma Cyperi, Cortex Moutan medicinal residues and all the other Flos Loniceraes after the Radix Angelicae Sinensis five tastes extract the medicinal residues behind the volatile oil and carry paeonol, Radix Paeoniae Rubra, Semen Persicae, Herba Patriniae, Caulis Sargentodoxae, the Semen Coicis Six-element adds 8-10 decocting doubly and boils 2 times, each 2 hours, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, the concentrated solution that to be concentrated into 60 ℃ of relative densities be 1.08-1.10, dosage 95% ethanol makes precipitation, left standstill 48 hours, getting the supernatant decompression recycling ethanol and being concentrated into 60 ℃ of relative densities is 1.30～1.35 thick paste, and above-mentioned all thick pastes are merged, add an amount of sucrose, dextrin, in 60-70 ℃ of vacuum drying, the pure one-tenth of powder fine powder is made granule, dry, add the inclusion complex of above-mentioned all volatile oil, mixing makes granule;
4. the preparation technology of the Chinese medicine of the described treatment gynaecopathia of claim 1, it is characterized in that by following step: the extraction of medicine, the extraction of alcohol extraction medicine: it is standby that Rhizoma Corydalis is ground into coarse powder, take by weighing 60% ethanol of 8 times of amounts of fumitory coarse powder adding, soaked 24 hours, reflux 2 hours, filter, 60% alcohol heating reflux 2 hours that adds 6 times of amounts again filters, and adds 60% alcohol heating reflux 1 hour of 6 times of amounts again, filter, merge three times ethanol extract, decompression recycling ethanol also is condensed into the thick paste of relative density 1.30-1.35, is standby Rhizoma Corydalis alcohol extraction cream; Contain the extraction of volatile oil medicine: take by weighing Ramulus Cinnamomi, Rhizoma Curcumae, Myrrha, Rhizoma Cyperi, Radix Angelicae Sinensis 5 herbal medicines, add 5 times of water gagings, extract volatile oil to most, about 6 hours, collect volatile oil, put cold place and preserve, be standby volatile oil; Aqueous solution after distillation device is in addition collected, and is incorporated in the decocting liquid to concentrate, and medicinal residues are incorporated in the water decoction-alcohol sedimentation medicine and decoct; The extraction of Cortex Moutan: take by weighing the Cortex Moutan of recipe quantity, add 6 times of water gagings, distill out paeonol, about 6 hours of time, after the drying, airtight preservation is standby paeonol; Aqueous solution after distillation device is in addition collected, and is incorporated in the decocting liquid to concentrate, and medicinal residues are incorporated in the water decoction-alcohol sedimentation medicine and decoct; The extraction of water decoction-alcohol sedimentation medicine: the decocting of medicine: the medicinal residues after taking by weighing the medicinal residues behind Flos Lonicerae, Radix Paeoniae Rubra, Semen Persicae, Herba Patriniae, Caulis Sargentodoxae, Semen Coicis and the extraction volatile oil of recipe quantity and extracting paeonol merge, decoct 2 times, the water that adds for the first time 10 times of amounts, add for the second time 8 times of water gagings, each 2 hours, collecting decoction is concentrated into 60 ℃ of relative density 1.08-1.10, is standby water drug-decocting concentrating liquid; Precipitate with ethanol: with above standby water drug-decocting concentrating liquid, put cold, under fully stirring, slowly add 1 times of amount 95% ethanol, add the back and continue to stir 15-20 minute, staticly settled 48 hours, filter, decompression filtrate recycling ethanol also is condensed into the thick paste of 60 ℃ of relative density 1.30-1.35, is standby water decoction-alcohol sedimentation condensed cream; The mixing of thick paste and the preparation of dried cream powder mix standby Rhizoma Corydalis alcohol extraction cream with standby water decoction-alcohol sedimentation condensed cream, in clear paste: sucrose: dextrin=1: 0: 6: 0.5 ratio adds adjuvant, and mixing in 60-70 ℃ of vacuum drying, is pulverized, and is standby dried cream powder; The preparation of β-CD inclusion complex: the preparation of volatile oil beta-CD inclusion complex: take by weighing the β-CD that is equivalent to 9 times of amounts of standby volatile oil, in β-CD: the ratio of water=1: 20 adds entry, slight fever makes dissolving, drip volatile oil, stirred 3 hours, put 0-4 ℃ and left standstill 24 hours at 30 ℃, sucking filtration, 40 ℃ of oven dry grind, and are standby; The preparation of paeonol β-CD inclusion complex: get standby paeonol, add an amount of dehydrated alcohol and make dissolving, standby; Take by weighing the β-CD that is equivalent to 12 times of amounts of standby paeonol again, after the water of β-CD and 2 times of amounts is ground well, drip the alcoholic solution of paeonol, fully be ground to into pastel, 40 ℃ dry by the fire in, grind, standby; The mixing of medicated powder and particulate preparation: with the alcohol granulation of standby dried cream fine powder with suitable concentration, oven dry, granulate, with volatile oil beta-CD inclusion complex, paeonol β-CD inclusion complex mix homogeneously, packing, promptly.
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| CN102327559A (en) * | 2011-09-23 | 2012-01-25 | 北京智博瑞宏科技有限公司 | Traditional Chinese medicine composition for curing a chronic pelvic inflammatory disease |
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| CN103330811B (en) * | 2013-07-10 | 2014-11-05 | 谭玉金 | Chinese herbal preparation for curing chronic pelvic inflammatory diseases |
| CN105233154A (en) * | 2015-10-22 | 2016-01-13 | 朱坤英 | Detoxifying decoction containing honeysuckle, fructus forsythiae and herba patriniae |
| CN117233306B (en) * | 2023-11-16 | 2024-01-30 | 江西省药品检验检测研究院 | Fingerprint establishment and component content determination method for jindan Fuyan particles |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1237451A (en) * | 1999-04-01 | 1999-12-08 | 魏秀珍 | Enema liquor for woman pelvic inflammation |
| CN1456236A (en) * | 2003-02-12 | 2003-11-19 | 毛友昌 | Preparation of woman effervescent tablets |
-
2004
- 2004-04-23 CN CNB2004100130815A patent/CN100368008C/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1237451A (en) * | 1999-04-01 | 1999-12-08 | 魏秀珍 | Enema liquor for woman pelvic inflammation |
| CN1456236A (en) * | 2003-02-12 | 2003-11-19 | 毛友昌 | Preparation of woman effervescent tablets |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113499412A (en) * | 2021-08-03 | 2021-10-15 | 江西华太药业有限公司 | Preparation method of Jindan Fuyan granules |
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|---|---|
| CN1689591A (en) | 2005-11-02 |
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