CN106620144B - Traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating chronic pelvic inflammation and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The medicine is prepared by processing the following Chinese medicinal materials: 12-18 parts of raw oldenlandia diffusa, 8-12 parts of white cockscomb flower, 5-7 parts of ginseng, 8-16 parts of sargentgloryvine stem, 8-12 parts of dipsacus root, 8-12 parts of szechwan chinaberry fruit, 8-10 parts of radix linderae, 8-16 parts of rhizoma cibotii, 8-12 parts of bighead atractylodes rhizome, 5-7 parts of xiaoxiang, 12-18 parts of white paeony root, 8-10 parts of medlar, 5-7 parts of cinnamon, 8-10 parts of rhizoma corydalis, 8-10 parts of rhizoma atractylodis, 12-18 parts of Chinese yam, 8-16 parts of radix bupleuri and 5-8 parts of honey-fried licorice root. The traditional Chinese medicine has the effects of resisting bacteria, diminishing inflammation, killing trichomonas, relieving pain, relieving spasm, improving the immune function of the organism and the like, can comprehensively condition and treat the whole body, has the effects of treating chronic pelvic inflammatory disease, improving the immune function of the organism, resisting blood coagulation, resisting tumors and the like.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease and a preparation method thereof.
Background
Chronic pelvic inflammation refers to inflammation of female internal genitalia (including uterus, oviduct, ovary) and connective tissue around the female internal genitalia and pelvic peritoneum, and is a general term for inflammation of female upper genital tract and tissues around the female upper genital tract. Mainly comprises endometritis, salpingitis, salpingo-ovarian abscess and pelvic peritonitis, and is the most common salpingitis.
Chronic pelvic inflammatory disease is one of the common causes of ectopic pregnancy and infertility. In recent years, the incidence rate of chronic pelvic inflammatory disease is on the rise year by year, and the chronic pelvic inflammatory disease is a common and frequent gynecological disease. Although the chronic pelvic inflammatory disease does not endanger the life of a patient, the chronic pelvic inflammatory disease causes the pain and anxiety of the patient due to symptoms such as long-term abdominal pain and swelling, lumbosacral pain, fatigue intolerance, ectopic pregnancy or infertility, discomfort or pain in sexual life and the like, and seriously affects the physical and mental health and the life quality of the patient, so the chronic pelvic inflammatory disease becomes a popular topic which is paid attention by a plurality of doctors recently.
Due to the wide use of antibiotics, bacteria can generate drug resistance, repeated inflammation causes fibrosis and thickening of genital organs and connective tissues in a pelvic cavity, the drug is not easy to permeate, and western medicines have great limitation on the treatment of pelvic inflammation and also have serious adverse reaction. Therefore, people pay more attention to the traditional Chinese medicine treatment, and the theory of the traditional Chinese medicine holds that the pelvic inflammation is caused by damp-heat, cold-dampness, qi stagnation, phlegm-dampness and qi deficiency, the disease property is the intermingled deficiency and excess, and the pathogenesis is characterized by uterus, uterus vessels, stasis and internal resistance. Based on different etiological characteristics, the traditional Chinese medicine generally adopts a treatment method based on syndrome differentiation, for example, pelvic inflammation is classified into damp-heat accumulation, which is the main syndrome: pain or burning pain in the lower abdomen or abdomen, lumbosacral soreness, menorrhagia or menstrual fever, menstrual disorder, dyspareunia, chronic infertility, profuse leucorrhea, yellow and sticky color, foul smell. The tongue proper is normal or red, the tongue coating is thin yellow or yellow greasy, and the pulse is surging and smooth, and the treatment is mainly to clear heat and promote diuresis; and (3) master certificate: the cold pain of the lower abdomen, aggravated by cold, reduced pain due to heat, soreness and pain of lumbosacral area, thin or fishy leucorrhea, increased abdominal pain in the lumbar region during menstrual period, small amount, dark red color, blood clots, hyposexuality or sexual intercourse pain, infertility, pale and dark tongue with thin and smooth coating, deep, thready and wiry pulse, which is treated mainly by warming the channel and dispelling cold. Although the syndrome differentiation has good treatment effect, in the treatment process, a patient needs to go back and forth to the hospital for many times, and the prescription changes at any time along with the deep treatment, so that the treatment cost is high on one hand, and the life of the patient is greatly influenced on the other hand. Therefore, the fixed prescription treatment is the most common treatment method, and the fixed prescription has more comprehensive treatment compared with the syndrome differentiation formula, but the treatment course is generally longer.
At present, many fixed formulas for treating chronic pelvic inflammation are available, such as angelica sinensis and peony powder disclosed by Zhang Zhen, which is prepared from angelica sinensis, ligusticum wallichii, poria cocos, bighead atractylodes rhizome, semen coicis, oldenlandia diffusa, sargentgloryvine stem, rhizoma alismatis and radix paeoniae alba, and the formula has the effects of resisting inflammation, tranquilizing and easing pain, and the clinical total effective rate is 97.5%; the salvia miltiorrhizae and baiyu sauce soup disclosed by the academic adults of plum and the like is prepared from salvia miltiorrhiza, patrinia, coix seeds, red paeony roots, sargentgloryvine stems, rhizoma cyperi, peach kernels, golden cypress, cinnamon, liquorice, rhizoma sparganii, curcuma zedoary and rhizoma atractylodis, and the total effective rate is 98.7 percent. However, the medicines can quickly and effectively treat the chronic pelvic inflammatory disease due to the direct disease caused by the incision point, but the treatment requirements are still difficult to meet.
Disclosure of Invention
The invention aims to: the Chinese medicine preparation for curing chronic pelvic inflammation is made up by using 18 Chinese medicinal materials through a certain preparation process, and possesses the functions of curing chronic pelvic inflammation, raising immunity of human body, resisting coagulation and resisting tumor, etc. it has the obvious therapeutic effect for curing the diseases of lumbago, leukorrhagia, abdominal distention and pain, dizziness, fatigue, light edema, urination, dysmenorrhea and irregular menstruation, etc. due to chronic pelvic inflammation, especially for curing spleen deficiency.
In order to achieve the purpose, the invention adopts the following technical scheme:
a traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease is characterized in that: is prepared by processing the following Chinese medicinal materials: 12-18 parts of raw oldenlandia diffusa, 8-12 parts of white cockscomb flower, 5-7 parts of ginseng, 8-16 parts of sargentgloryvine stem, 8-12 parts of dipsacus root, 8-12 parts of szechwan chinaberry fruit, 8-10 parts of radix linderae, 8-16 parts of rhizoma cibotii, 8-12 parts of bighead atractylodes rhizome, 5-7 parts of xiaoxiang, 12-18 parts of white paeony root, 8-10 parts of medlar, 5-7 parts of cinnamon, 8-10 parts of rhizoma corydalis, 8-10 parts of rhizoma atractylodis, 12-18 parts of Chinese yam, 8-16 parts of radix bupleuri and 5-8 parts of honey-fried licorice root.
Preferably, the traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease is characterized in that: is prepared by processing the following Chinese medicinal materials: 14-16 parts of raw oldenlandia diffusa, 10-11 parts of white cockscomb flower, 5.5-6.5 parts of ginseng, 11-13 parts of sargentgloryvine stem, 9-11 parts of dipsacus root, 9-11 parts of szechwan chinaberry fruit, 8.5-9.5 parts of radix linderae, 10-14 parts of rhizoma cibotii, 9-11 parts of bighead atractylodes rhizome, 5.5-6.5 parts of xiaoxiang, 14-16 parts of white paeony root, 8.5-9.5 parts of medlar, 5.5-6.5 parts of cinnamon, 8.5-9.5 parts of rhizoma corydalis, 8.5-9.5 parts of rhizoma atractylodis, 14-16 parts of Chinese yam, 10-14 parts of radix bupleuri and 6-7 parts of honey-fried licorice root.
Preferably, the traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease is characterized in that: is prepared by processing the following Chinese medicinal materials: 15 parts of raw oldenlandia diffusa, 10.5 parts of white cockscomb, 6 parts of ginseng, 12 parts of sargentgloryvine stem, 10 parts of dipsacus root, 10 parts of szechwan chinaberry fruit, 8-10 parts of radix aconiti, 12 parts of rhizoma cibotii, 10 parts of bighead atractylodes rhizome, 6 parts of xiaoxiang, 15 parts of white paeony root, 9 parts of medlar, 6 parts of cinnamon, 9 parts of rhizoma corydalis, 9 parts of rhizoma atractylodis, 15 parts of Chinese yam, 12 parts of radix bupleuri and 6.5 parts of honey-fried licorice root.
Furthermore, the preparation types of the traditional Chinese medicine preparation for treating the chronic pelvic inflammatory disease comprise granules, powder and capsules.
The invention also discloses a preparation method of the capsule for treating chronic pelvic inflammatory disease, which comprises the following steps:
1) selecting materials: in the above formula, radix Glycyrrhizae is old root radix Glycyrrhizae for more than 3 years, and the rest is fresh high-quality medicinal materials in the current year;
2) material cleaning: washing the selected medicinal materials with tap water to remove dirt and impurities and inferior medicinal materials;
3) and (3) disinfection: spraying 75% alcohol on the raw materials, and covering with clean cotton material for 48 hr;
4) and (3) drying: after the disinfection, putting the raw medicinal materials into an oven, drying for 3-5 hours at 60 ℃, and taking out the medicinal materials when the water content is detected to be less than or equal to 13%;
5) crushing: pulverizing the above materials, sieving with 120 mesh sieve, and mixing the medicinal powders;
6) filling capsules: filling the capsule by using a capsule filling machine, and removing the medicinal powder adhered to the outer surface of the capsule shell by using a polishing machine;
7) polishing and quality inspection: and (5) inspecting unqualified products. Irradiating at a cobalt 60 irradiation station; packaging and warehousing the qualified products after quality inspection.
The pharmacological research of the traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease of the invention is as follows:
the ginseng in the prescription: 1) the sexual gland function is enhanced, the gonadotropin-secreting effect of the excitatory pituitary is achieved, the sexual maturation process of a rat can be accelerated, the estrus of a female mouse which is not grown up is accelerated, the weight of the uterine ovary is increased, and the secretion of luteinizing hormone is increased; 2) enhancing immune function; 3) the ginsenoside has obvious inhibition effect on acute and chronic inflammation, can obviously inhibit rat foot swelling caused by acetic acid and carrageenin, and can reduce the concentration of hydroxyproline in inflammatory tissues. Rhizoma atractylodis: the rhizoma Atractylodis extract has the effect of eliminating drug-resistant Shigella flexneri plasmid, and can reduce the generation of drug resistance of bacteria. White atractylodes rhizome: 1) the immunity of the organism is enhanced, and the white atractylodes rhizome can obviously enhance the capability of white blood cells to phagocytose staphylococcus aureus; 2) the rhizoma atractylodis macrocephalae has the effects of resisting fatigue and enhancing the function of adrenal cortex; 3) the bighead atractylodes rhizome has the effect of promoting hematopoiesis of mouse erythrocytes; 4) resisting oxidation and delaying aging; 5) has antitumor effect, and can reduce proliferation rate of tumor cells, reduce invasiveness of tumor tissue, and improve antitumor response capability of organism. Cinnamon: 1) the cinnamon extract has obvious inhibition effects on the foot swelling of a rat caused by carrageenan, the auricle swelling of a mouse caused by dimethylbenzene and the granulation tissue hyperplasia of the rat caused by cotton balls; 2) the cinnamon water decoction can reduce the times of mouse writhing caused by acetic acid, can prolong the incubation period of mouse heat stimulation reaction, and has an inhibition effect on pain caused by heat stimulation, chemical stimulation and tail pressing stimulation; 3) has antibacterial effect, and cinnamaldehyde has antibacterial effect on 22 kinds of 31 strains of conditional pathogenic fungi, and has the characteristics of wide antibacterial spectrum and low toxicity. The cinnamon decoction and alcohol and ether immersion liquid of cinnamon have obvious inhibiting and killing effects on various pathogenic dermatophytes such as the fresh mauve bacteria, the candida albicans and the like, and the cinnamon oil also has an inhibiting effect on gram positive bacteria. Rhizoma corydalis: 1) the analgesic effect is obvious in alcohol extract, vinegar extract, powder and the like of the corydalis tuber, the analgesic effect of the corydalis tuber total alkali is 40 percent of that of morphine, and the analgesic effect of tetrahydropalmatine is strongest and is third-order. The weakest element A; 2) the relaxation of smooth muscle can obviously resist the contraction of isolated uterus of rats caused by oxytocin and potassium chloride. Toosendan fruit: 1) antibacterial, anti-inflammatory and antiviral effects; 2) has effect in inhibiting Candida albicans; 3) has inhibitory effect on fungi; 4) has tumor cell inhibiting effect. White peony root: 1) spasmolysis, which has inhibition effect on spontaneous contraction of uterine smooth muscle of rat and contraction caused by oxytocin; 2) the white peony root extract can inhibit the acute foot swelling and cotton ball granuloma of a rat caused by egg white, and the medicine is effective on acute exudative inflammation and proliferative inflammation; 3) enhancing immunity, and increasing phagocytic function of macrophage by radix Paeoniae alba in vivo and in vitro; 4) the white peony root decoction has anti-inflammatory and antiviral effects, has an inhibiting effect on Shigella shigella, staphylococcus, pseudomonas aeruginosa and the like in vitro, has an inhibiting effect on pathogenic fungi, has a direct antiviral effect on total sweetness of white peony root, and obviously reduces the titer of the vesicular phlegm virus by 250 g/L. Medlar: 1) enhancing immunity, wherein fructus Lycii can enhance nonspecific immunity, and water extract and alcohol extract of fructus Lycii can improve phagocytic function of macrophage; 2) delaying aging, wherein the medlar is used for delaying aging, promoting the elimination of free radicals in vivo, resisting oxidation and improving the immune function of organisms. And improving the DNA repair capacity. Licorice root: 1) antibacterial, antiviral, antiinflammatory, antiallergic, and Glycyrrhrizae radix flavonoids have effects of inhibiting Staphylococcus aureus, Bacillus subtilis, yeast, fungi, and streptococcus; 2) glycyrrhrizae radix has corticoid-like effect; 3) regulating organism immunity, wherein glycyrrhizic acid mainly has the functions of enhancing macrophage phagocytosis and enhancing cell immunity, but has inhibition effect on humoral immunity; 4) the glycyrrhizic acid has obvious inhibition effect on the occurrence of pre-liver cancer lesions of rats induced by aflatoxin and diethylnitrosamine. Herba Hedyotidis Diffusae: 1) the compound has an anti-tumor effect, and has strong inhibition effect on tumor cells of acute lymphocyte type, monocyte type, granulocyte type and chronic granulocyte type in vitro; 2) antibacterial effect, and has inhibiting effect on Staphylococcus aureus, Shigella flexneri, Bacillus typhi, Pseudomonas aeruginosa, etc.; 3) has antiinflammatory effect by enhancing defense ability. Sargentgloryvine stem: the 25% decoction has extremely sensitive antibacterial effect on staphylococcus aureus and streptococcus B, and has high sensitive antibacterial effect on Escherichia coli, Pseudomonas aeruginosa, Streptococcus A, Streptococcus catarrhalis, and Staphylococcus albus. White cockscomb: the test tube method proves that the cockscomb decoction has good killing effect on trichomonas vaginalis. And (3) Himalayan teasel root: contains alkaloid, volatile oil and vitamin E, 1) the water decoction of radix Dipsaci has strong exciting effect on isolated uterus of rabbit, and is manifested by enhanced frequency, increased tension, and most of them is in tonic contraction state; 2) has effects in killing trichomonas vaginalis and resisting vitamin E deficiency; 3) has hemostatic and analgesic effects. A Taiwu: 1) the bacteriostatic action, which has inhibitory action on staphylococcus aureus, alpha hemolytic streptococcus, typhoid bacillus, proteus, pseudomonas aeruginosa and escherichia coli; 2) the hemostatic effect, in vitro tests prove that the lindera aggregate dry powder can obviously shorten the recalcification time of rabbits. Promoting blood coagulation and good hemostasis effect; 3) has antitumor effect, and can inhibit mouse sarcoma-180. Rhizoma cibotii: 1) the powder extracted from rhizoma Cibotii is used for wound hemostasis, has certain hemostatic effect on scar tissue, liver and spleen traumatic hemorrhage, and is quicker than gelatin sponge; 2) the rhizoma cibotii can obviously prolong the survival time of the experimental animals with ehrlich ascites carcinoma and S180 ascites carcinoma. Small fragrance: 1) sex hormone nourishing effect, female rat uses acetone extract for 10 days, vagina keratosis and sexual cycle promotion appear, weight of mammary gland, oviduct, endometrium and myometrium is increased, fennel has estrogen-like effect; 2) the fructus Foeniculi extract polysaccharide has anti-tumor effect, and the volatile oil has antibacterial effect on its fungus seed, Mycobacterium avium, and Staphylococcus aureus. Chinese yam: 1) the preparation has obvious normal-pressure hypoxia-resistant effect, can obviously reduce the damage of mouse viscera to hypoxia environment, and improves the tolerance; 2) the Chinese yam can obviously increase the weight of the spleen of a mouse due to the influence on the immune function, and the Chinese yam polysaccharide can effectively resist the inhibiting immune effect of cyclophosphamide. Bupleurum root: 1) the oral saikosaponin has obvious analgesic effect; 2) the experiment proves that the anti-inflammatory intensity of the saikosaponin is similar to that of prednisolone, and the anti-granuloma hyperplasia of bupleurum is stronger than the anti-exudation effect; 3) experiments show that the bupleurum polysaccharide can improve the humoral immunity and the cellular immunity of mice and recover the immunosuppression state to a certain degree.
The prescription analysis of the traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease is as follows:
in the formula, the oldenlandia diffusa has the effects of clearing away heat and toxic materials, promoting diuresis and stopping leukorrhagia; rhizoma atractylodis and rhizoma atractylodis macrocephalae are used as main medicines in the formula, and are matched with rhizoma dioscoreae and ginseng to tonify qi and strengthen spleen, so that the effect of the rhizoma atractylodis macrocephalae in strengthening spleen is enhanced; rhizoma corydalis and fructus Toosendan are adjuvant drugs for promoting blood circulation, regulating qi-flowing and relieving pain, and radix Linderae and cortex Cinnamomi are used for warming yang and dispelling cold, regulating qi-flowing and relieving pain; the medlar and the dipsacus root, radix dipsaci from Sichuan of China, are adjuvant drugs for nourishing the liver and kidney, promoting blood circulation and dredging collaterals; the prepared licorice root is used for harmonizing the medicines, tonifying middle-jiao and Qi and moderating the property of the medicines. The compatibility of the whole formula ensures that spleen qi is healthy and healthy, kidney qi is sufficient, yang qi is vigorous, cold is dispersed, qi is passed through, and damp toxin is removed, so the traditional Chinese medicine is a special prescription for treating leukorrhagia.
According to the pharmacological analysis of modern medicine, the traditional Chinese medicine has good treatment effect on chronic pelvic inflammation because the traditional Chinese medicine has the effects of inhibiting and killing staphylococcus aureus, hemolytic streptococcus, streptococcus B, catacoccus, escherichia coli, pseudomonas aeruginosa, tubercle bacillus, fungi, trichomonas, tumor cells and cancer cells, and has the effects of easing pain, relieving spasm, improving immunity of the organism, resisting aging and the like.
In conclusion, the recipe meets the compatibility principle of the traditional Chinese medicine prescription, has no contradiction with the incompatibility of the traditional Chinese medicines, and has the effects of warming and invigorating spleen and kidney, promoting blood circulation to remove blood stasis, removing dampness, astringing leucorrhea, detoxifying and promoting diuresis. The modern medical pharmacology research proves that the medicine has the effects of resisting bacteria and diminishing inflammation, improving the immunologic function of organisms, easing pain, relieving spasm, resisting blood coagulation, resisting tumors and the like. Therefore, the two different medical ideas are matched, and the recipe is fully proved to have the effect of treating the leukorrheal diseases of women.
Compared with the prior art, the invention has the beneficial effects that:
1) the traditional Chinese medicine preparation disclosed by the invention has the effects of warming and invigorating spleen and kidney, activating blood circulation to dissipate blood stasis, detoxifying and removing dampness and astringing to leucorrhea, is clinically used for treating symptoms such as lumbago caused by chronic pelvic inflammation, leukorrhagia, or yellow and white leucorrhea with the symptoms of tenesmus, lower abdomen ice swelling and pain, dizziness and fatigue, mild edema, urinary stranguria, dysmenorrhea, irregular menstruation and the like, particularly has a remarkable curative effect on spleen deficiency, and has no toxic or side effect except for the patients with cold with cautions through clinical research of subjects in 6 years, and the total effective rate is 94.4%.
2) The traditional Chinese medicine has the effects of resisting bacteria, diminishing inflammation, killing trichomonas, relieving pain, relieving spasm, improving the immune function of the organism and the like, can comprehensively condition and treat the whole body, has the effects of treating chronic pelvic inflammatory disease, improving the immune function of the organism, resisting blood coagulation, resisting tumors and the like.
Detailed Description
The technical solutions of the present invention are further described below with reference to specific examples to facilitate understanding for those skilled in the art.
Example 1
A traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease is prepared into capsules according to the following steps:
1) weighing the following medicinal materials in parts by weight: 15 parts of raw oldenlandia diffusa, 10.5 parts of white cockscomb, 6 parts of ginseng, 12 parts of sargentgloryvine stem, 10 parts of dipsacus root, 10 parts of szechwan chinaberry fruit, 8-10 parts of radix aconiti, 12 parts of rhizoma cibotii, 10 parts of bighead atractylodes rhizome, 6 parts of xiaoxiang, 15 parts of white paeony root, 9 parts of medlar, 6 parts of cinnamon, 9 parts of rhizoma corydalis, 9 parts of rhizoma atractylodis, 15 parts of Chinese yam, 12 parts of radix bupleuri and 6.5 parts of honey-fried licorice root;
in the above formula, radix Glycyrrhizae is old root radix Glycyrrhizae for more than 3 years, and the rest is fresh high-quality medicinal materials in the current year;
2) material cleaning: washing the selected medicinal materials with tap water to remove dirt and impurities and inferior medicinal materials;
3) and (3) disinfection: spraying 75% alcohol on the raw materials, and covering with clean cotton material for 48 hr;
4) and (3) drying: after the disinfection, putting the raw medicinal materials into an oven, drying for 3-5 hours under the condition of 600 ℃, and taking out the medicinal materials when the water content is detected to be less than or equal to 13%;
5) crushing: pulverizing the above materials, sieving with 120 mesh sieve, and mixing the medicinal powders;
6) filling capsules: filling the capsule by using a capsule filling machine, and removing the medicinal powder adhered to the outer surface of the capsule shell by using a polishing machine;
7) polishing and quality inspection: and (5) inspecting unqualified products. Irradiating at a cobalt 60 irradiation station; packaging and warehousing the qualified products after quality inspection.
Example 2
A traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease is prepared into powder according to the following steps:
1) weighing the following medicinal materials in parts by weight: 14 parts of raw oldenlandia diffusa, 10 parts of white cockscomb flower, 5.5 parts of ginseng, 11 parts of sargentgloryvine stem, 9 parts of dipsacus root, 9 parts of szechwan chinaberry fruit, 8.5 parts of radix aconiti, 10 parts of rhizoma cibotii, 9 parts of bighead atractylodes rhizome, 5.5 parts of xiaoxiang, 14 parts of white peony root, 8.5 parts of medlar, 5.5 parts of cinnamon, 8.5 parts of rhizoma corydalis, 8.5 parts of rhizoma atractylodis, 14 parts of Chinese yam, 10 parts of radix bupleuri and 6 parts of honey-fried licorice root;
in the above formula, radix Glycyrrhizae is old root radix Glycyrrhizae for more than 3 years, and the rest is fresh high-quality medicinal materials in the current year;
2) material cleaning: washing the selected medicinal materials with tap water to remove dirt and impurities and inferior medicinal materials;
3) and (3) disinfection: spraying 75% alcohol on the raw materials, and covering with clean cotton material for 48 hr;
4) and (3) drying: after the disinfection, putting the raw medicinal materials into an oven, drying for 3-5 hours at 60 ℃, and taking out the medicinal materials when the water content is detected to be less than or equal to 13%;
5) crushing: pulverizing the above materials, sieving with 120 mesh sieve, and mixing the medicinal powders;
6) polishing and quality inspection: and (5) inspecting unqualified products. Irradiating at a cobalt 60 irradiation station; packaging and warehousing the qualified products after quality inspection.
Example 3
A traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease is prepared into granules according to the following steps:
1) weighing the following medicinal materials in parts by weight: 16 parts of raw oldenlandia diffusa, 11 parts of white cockscomb flower, 6.5 parts of ginseng, 13 parts of sargentgloryvine stem, 11 parts of dipsacus root, 11 parts of szechwan chinaberry fruit, 9.5 parts of radix aconiti, 14 parts of rhizoma cibotii, 11 parts of bighead atractylodes rhizome, 6.5 parts of xiaoxiang, 16 parts of white peony root, 9.5 parts of medlar, 6.5 parts of cinnamon, 9.5 parts of rhizoma corydalis, 9.5 parts of rhizoma atractylodis, 16 parts of Chinese yam, 14 parts of radix bupleuri and 7 parts of honey-fried licorice root;
in the above formula, radix Glycyrrhizae is old root radix Glycyrrhizae for more than 3 years, and the rest is fresh high-quality medicinal materials in the current year;
2) material cleaning: washing the selected medicinal materials with tap water to remove dirt and impurities and inferior medicinal materials;
3) and (3) disinfection: spraying 75% alcohol on the raw materials, and covering with clean cotton material for 48 hr;
4) and (3) drying: after the disinfection, putting the raw medicinal materials into an oven, drying for 3-5 hours at 60 ℃, and taking out the medicinal materials when the water content is detected to be less than or equal to 13%;
5) crushing: pulverizing the above materials, sieving with 120 mesh sieve, and mixing the medicinal powders;
6) preparing particles: adding a proper amount of honey into the mixed medicinal powder obtained in the step 5), and preparing the mixture into powder according to a powder preparation process;
7) polishing and quality inspection: irradiating the product with unqualified quality inspection at a cobalt 60 irradiation station; packaging and warehousing the qualified products after quality inspection.
Example 4
A traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease can be prepared into any dosage form of powder, granules or capsules according to the processes of examples 1, 2 and 3, and the specific gravity of the medicine formula is as follows: 12 parts of raw oldenlandia diffusa, 8 parts of white cockscomb, 5 parts of ginseng, 8 parts of sargentgloryvine stem, 8 parts of dipsacus root, 8 parts of szechwan chinaberry fruit, 8 parts of radix aconiti agrestis, 8 parts of rhizoma cibotii, 8 parts of bighead atractylodes rhizome, 5 parts of xiaoxiang, 12 parts of white paeony root, 8 parts of medlar, 5 parts of cinnamon, 8 parts of rhizoma corydalis, 8 parts of rhizoma atractylodis, 12 parts of Chinese yam, 8 parts of radix bupleuri and 5 parts of honey-fried licorice root.
Example 5
A traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease can be prepared into any dosage form of powder, granules or capsules according to the processes of examples 1, 2 and 3, and the specific gravity of the medicine formula is as follows: 18 parts of raw spreading hedyotis herb, 12 parts of white cockscomb flower, 7 parts of ginseng, 16 parts of sargentgloryvine stem, 12 parts of dipsacus root, 12 parts of szechwan chinaberry fruit, 10 parts of Taiwu, 16 parts of rhizoma cibotii, 12 parts of bighead atractylodes rhizome, 7 parts of xiaoxiang, 18 parts of white paeony root, 10 parts of medlar, 7 parts of cinnamon, 10 parts of rhizoma corydalis, 10 parts of rhizoma atractylodis, 18 parts of Chinese yam, 16 parts of radix bupleuri and 8 parts of honey-fried licorice root.
The actual therapeutic effect of the Chinese medicinal preparation of the present invention will be described below with reference to clinical data.
1. General data
The chronic pelvic inflammatory disease is confirmed by gynecological examination and B-ultrasonic diagnosis, not only has obvious clinical symptoms and physical signs, but also has clinical manifestations of spleen deficiency type, kidney deficiency type and damp-heat and damp-toxin type in traditional Chinese medicine as research medical records, cefalexin capsules, norfloxacin oral administration and 200ml of tinidazole intravenous drip combined application are used as a control group, random grouping and parallel control are adopted, except for different medicines, other conditions of the control group are completely the same as those of a treatment group, and 300 cases of the treatment group and 100 cases of the control group are outpatient medical records.
1.1 treatment groups: patients are 50 years old at the maximum age, 22 years old at the minimum age, 36 years old at the average age, 5 years old at the longest course, half a year at the shortest age, and 2.75 years at average. The medical record survey shows that 300 patients have not been treated systematically, which belongs to the outpatient medical record.
1.2 control group: the patients with the highest age were 48 years old, the patients with the lowest age were 25 years old, the average age was 36.5 years old, the patients with the longest course were 5 years old, the patients with the shortest course were 1 year old, and the patients with the longest course were 3 years old on average, and medical records showed that 100 patients were not treated systemically, and the patients were in clinic medical records.
2. Diagnostic criteria and Chinese medicine typing
2.1 diagnostic criteria:
2.1.1 all the cases have pain on one side or both sides of the lower abdomen, accompanied by lumbago or lumbosacral pain, leukorrhagia, etc., and are usually aggravated after fatigue or sexual intercourse and before and after menstruation, or menstrual disorder, or dysmenorrhea, or secondary infertility history.
2.1.2 gynecological examination: the most of the uterus positions are the posterior position, the movement is limited or fixed, and the attachments on one side or two sides are thickened or in a cord shape. Tenderness, thickening of one or both sides of the connective tissue around the uterus, or cord-like thickening of the connective tissue.
2.2 Chinese medicine typing
Typing is carried out according to leukorrhagia of the fifth edition of the teaching materials of higher medical institutions of traditional Chinese medicine and gynecology.
3. Method of treatment
The composition can be orally administered before or after meals. The control group was treated with metronidazole in addition to oral cefalexin capsules. Both the treatment group and the control group tried to avoid fatigue during the administration period, and the sexual life was observed, and the hygiene during the menstruation period was noted. The treatment course is 30 days, and the treatment effect is evaluated after two groups are taken for one treatment course.
3.1 treatment group: the medicine is taken with warm boiled water 5 capsules each time, three times a day, and one treatment course is continued, wherein the medicine is a Gongbasin health capsule (the specification is 0.3 g).
3.2 control group: 0.25 g of cefalexin capsule and 0.2 g of norfloxacin are taken at the same time three times a day. The medicine is taken with warm water continuously for one treatment course (combined with tinidazole 200ml intravenous drip once a day, and used continuously for 5 days).
4. Standard of therapeutic effect
Is determined according to the first book of the standard of curative effect of diagnosis of traditional Chinese medicine diseases issued by the State administration of traditional Chinese medicine, 1994-06-28.
4.1 cure: clinical symptoms completely disappear, and the physical signs of the gynecological pelvic examination (such as tenderness, thickening of attachments, fixed uterine adhesion and inflammatory mass) are completely restored to be normal.
4.2 improvement: the clinical symptoms are obviously improved, and the gynecological pelvic examination (such as tenderness, adnexal thickening, uterine adhesion fixation and inflammatory mass) is obviously improved or reduced.
4.3 invalid: no obvious change in clinical symptoms and signs.
5. Therapeutic results
5. 1, the total effective rate of 300 cases in a treatment group is 94.4%, and compared with the 81% curative effect of 100 control groups (detailed in table I), P is less than 0.01, and the difference has very significant significance.
TABLE 1 statistical Table of the total efficacy of the treatment groups and the control group
| Grouping | Cure (%) | Improvement (%) | Null (%) | Total effective rate (%) |
| Treatment group | 158(52.7) | 125(41.7) | 17(5.7) | 94.4 |
| Control group | 29(29) | 52(52) | 19(19) | 81 |
Warp X2Inspection, P<0.01 indicates that the curative effect of the treatment group is obviously better than that of the control group.
5.2 Chinese medicine syndrome differentiation and therapeutic effect relationship statistical table (see Table II for details)
TABLE II statistical table of the relationship between syndrome differentiation and therapeutic effect of TCM
6. Discussion of the related Art
The gongfukang capsule formula has the functions of warming and invigorating spleen and kidney, promoting blood circulation to remove blood stasis, detoxifying and removing dampness, and astringing to leucorrhea, is clinically used for treating symptoms such as waist encumbrance lumbago, leukorrhagia, or yellow and white leucorrhea which are accompanied with each other, tenesmus, lower abdomen ice swelling and pain, dizziness and fatigue, mild edema, urination stranguria, dysmenorrheal, irregular menstruation and the like caused by chronic pelvic inflammatory disease, particularly has obvious curative effect on spleen deficiency type, and has no toxic or side effect except the cautious use of cold patients through clinical research of subject groups of 6 years, and the total effective rate is 94.4%.
The modern medical pharmacology research proves that the product has better effects of resisting bacteria, diminishing inflammation, killing trichomonas, easing pain, relieving spasm, improving the immunity of the organism and the like.
Claims (5)
1. A traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease is characterized in that: is prepared by processing the following Chinese medicinal materials: 12-18 parts of raw oldenlandia diffusa, 8-12 parts of white cockscomb flower, 5-7 parts of ginseng, 8-16 parts of sargentgloryvine stem, 8-12 parts of dipsacus root, 8-12 parts of szechwan chinaberry fruit, 8-10 parts of radix linderae, 8-16 parts of rhizoma cibotii, 8-12 parts of bighead atractylodes rhizome, 5-7 parts of xiaoxiang, 12-18 parts of white paeony root, 8-10 parts of medlar, 5-7 parts of cinnamon, 8-10 parts of rhizoma corydalis, 8-10 parts of rhizoma atractylodis, 12-18 parts of Chinese yam, 8-16 parts of radix bupleuri and 5-8 parts of honey-fried licorice root.
2. The traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease according to claim 1, wherein: is prepared by processing the following Chinese medicinal materials: 14-16 parts of raw oldenlandia diffusa, 10-11 parts of white cockscomb flower, 5.5-6.5 parts of ginseng, 11-13 parts of sargentgloryvine stem, 9-11 parts of dipsacus root, 9-11 parts of szechwan chinaberry fruit, 8.5-9.5 parts of radix linderae, 10-14 parts of rhizoma cibotii, 9-11 parts of bighead atractylodes rhizome, 5.5-6.5 parts of xiaoxiang, 14-16 parts of white paeony root, 8.5-9.5 parts of medlar, 5.5-6.5 parts of cinnamon, 8.5-9.5 parts of rhizoma corydalis, 8.5-9.5 parts of rhizoma atractylodis, 14-16 parts of Chinese yam, 10-14 parts of radix bupleuri and 6-7 parts of honey-fried licorice root.
3. The traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease according to claim 1, wherein: is prepared by processing the following Chinese medicinal materials: 15 parts of raw oldenlandia diffusa, 10.5 parts of white cockscomb, 6 parts of ginseng, 12 parts of sargentgloryvine stem, 10 parts of dipsacus root, 10 parts of szechwan chinaberry fruit, 8-10 parts of radix aconiti, 12 parts of rhizoma cibotii, 10 parts of bighead atractylodes rhizome, 6 parts of xiaoxiang, 15 parts of white paeony root, 9 parts of medlar, 6 parts of cinnamon, 9 parts of rhizoma corydalis, 9 parts of rhizoma atractylodis, 1 part of Chinese yam, 12 parts of radix bupleuri and 6.5 parts of honey-fried licorice root.
4. The traditional Chinese medicine preparation for treating chronic pelvic inflammatory disease of claim 1, 2 or 3, wherein: the preparation types comprise granules, powder and capsules.
5. A method for preparing a Chinese medicinal preparation for treating chronic pelvic inflammatory disease according to claim 4, which is characterized by comprising the following steps: the capsule preparation comprises the following steps:
1) selecting materials: in the above formula, radix Glycyrrhizae is old root radix Glycyrrhizae for more than 3 years, and the rest is fresh high-quality medicinal materials in the current year;
2) material cleaning: washing the selected medicinal materials with tap water to remove dirt and impurities and inferior medicinal materials;
3) and (3) disinfection: spraying 75% alcohol on the raw materials, and covering with clean cotton material for 48 hr;
4) and (3) drying: after the disinfection, putting the raw medicinal materials into an oven, drying for 3-5 hours at 60 ℃, and taking out the medicinal materials when the water content is detected to be less than or equal to 13%;
5) crushing: pulverizing the above materials, sieving with 120 mesh sieve, and mixing the medicinal powders;
6) filling capsules: filling the capsule by using a capsule filling machine, and removing the medicinal powder adhered to the outer surface of the capsule shell by using a polishing machine;
7) polishing and quality inspection: irradiating the product with unqualified quality inspection at a cobalt 60 irradiation station; packaging and warehousing the qualified products after quality inspection.
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