CN103191370B - Medicine composite for treating mastitis and preparation method and application of medicine composite - Google Patents
Medicine composite for treating mastitis and preparation method and application of medicine composite Download PDFInfo
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Abstract
The invention provides a medicine composite for treating mastitis. The medicine composite is prepared from the following medicinal raw materials in parts by weight: 9-15 parts of astragalus, 20-28 parts of dried taraxacum or 40-55 parts of fresh taraxacum, 9-15 parts of honeysuckle, 6-10 parts of fritillaria, 16-24 parts of spina gleditsiae, 7-13 parts of dahurian angelica root, 6-10 parts of radix saposhnikoviae, 7-13 parts of olibanum, 7-13 parts of myrrh, 7-13 parts of radix angelicae sinensis, 7-13 parts of red peony root, 6-10 parts of stir-fried pangolin scales, 7-13 parts of tangerine peel, 9-15 parts of sankegourd fruit shell, 9-15 parts of turmeric root tuber, 16-24 parts of radices trichosanthis and 6-10 parts of licorice section. The medicine composite can be used for effectively treating mammary abscess or acute suppurative mastitis due to heat transformed from milk deposition, toxic heat accumulation and qi and blood stagnation and supplies a new choice to clinical medication.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of mastitis and its production and use.
Background technology
Acute mastitis, means breast congestion and swelling pain, and milk is discharged not smooth, so that ties pus and become the acute festering type disease of carbuncle.System is because of human milk silt heat-transformation, and pyretic toxicity pents up, stagnation of QI-blood causes, disease opinion is generally distending pain of the breast, local Pi Wengao, there is ill-defined scleroma, even local skin is red, swollen, hot, bitterly, occur significantly scleroma, touch a tender spot more very, or companion shiver with cold, high heat, headache, unable, axillary lymph are tied enlargement, red tongue tongue or greasy, Se Bai or Huang, rapid pulse is strong, or sliding or string.
The acute purulent mammitis of modern medicine belongs to acute mastitis category, and it is the acute festering type infection of breast, is puerperal commonly encountered diseases, is more common in nursing women, and particularly primipara is the most multiple in the incipient stage of suckling.Its pathogenic factor, the one, due to the alluvial of milk, the 2nd, because the intrusion of antibacterial.The reason of human milk silt can or be caved in because of hypomastia, hinders suckling; Or because of hypergalactosis, and puerpera is not in time by emptying unnecessary milk in breast; Or obstructed because of latex dust, latex dust itself has inflammation, tumor or external compressing, all can cause latex dust obstructed, and in addition, the fiber that medicated bra comes off also can stop up latex dust, causes obstructed.The intrusion of antibacterial is taking staphylococcus aureus as common.Mastitis harm is very large, and severe patient can concurrent general pyogenic infection.Its from the beginning of time, mammary swelling, pain, have lump tenderness, surface is red and swollen, heating, the symptom that continues increases the weight of, breast is throbbing pain, can accompany hyperpyrexia, shiver with cold, agitation, headache, weak, dry stool knot etc., the enlargement of Ipsilateral axillary lymph knot, tenderness.If treatment not in time or malpractice, its abscess can be worn out loose connective tissue before pectoralis major fascia, forms retromammary abscess, or milk overflows and form mammary fistula from wound place, and very pyaemia septica can occur person.
Due to the women that acute mastitis is mainly in age of sucking, if give Western medicine, to the adverse effect that nourished the baby on mother's milk, therefore mostly advise Chinese medicine.Most Chinese medicine is natural plants, and the Chinese medicine not high violent person's prescription of drug of choice completely for the treatment of primary disease, can not produce harmful effect to breast feeding.Even if need not breastfeeding patient, use heavy dose of antibiotic therapy primary disease, also can bring " fastbacteria problem ", the traditional Chinese medical science has the advantage of evading doctor trained in Western medicine and use many toxic and side effects that a large amount of antibiotic bring.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of mastitis and its production and use.
The invention provides a kind of pharmaceutical composition for the treatment of mastitis, it is the preparation being prepared from by the crude drug of following weight proportion:
Radix Astragali 9-15 part, 40～55 parts of Herba Taraxaci dry product 20-28 part or Herba Taraxaci fresh goods, Flos Lonicerae 9-15 part, Bulbus Fritillariae Uninbracteatae 6-10 part, Spina Gleditsiae 16-24 part, Radix Angelicae Dahuricae 7-13 part, Radix Saposhnikoviae 6-10 part, Olibanum 7-13 part, Myrrha 7-13 part, Radix Angelicae Sinensis 7-13 part, Radix Paeoniae Rubra 7-13 part, stir-baked SQUAMA MANITIS 6-10 part, Pericarpium Citri Reticulatae 7-13 part, Fructus Trichosanthis shell 9-15 part, Radix Curcumae 9-15 part, Radix Trichosanthis 16-24 part, Radix Glycyrrhizae uralensis 6-10 part.
Further, it is the preparation being prepared from by the crude drug of following weight proportion:
12 parts of the Radixs Astragali, 48 parts of 24 parts of Herba Taraxaci dry products or Herba Taraxaci fresh goods, 12 parts of Flos Loniceraes, 8 parts of Bulbus Fritillariae Uninbracteataes, 20 parts of Spina Gleditsiaes, 10 parts of the Radixs Angelicae Dahuricae, 8 parts of Radix Saposhnikoviaes, 10 parts of Olibanums, 10 parts of Myrrhas, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Paeoniae Rubras, 8 parts of stir-baked SQUAMA MANITISs, 10 parts of Pericarpium Citri Reticulataes, 12 parts of Fructus Trichosanthis shells, 12 parts of Radix Curcumaes, 20 parts of Radix Trichosanthis, 8 parts of Radix Glycyrrhizae uralensiss.
Wherein, the described Radix Astragali is Radix Astragali; Described Spina Gleditsiae is for frying Spina Gleditsiae, and raw product drug effect subtracts greatly, and it is substantially invalid maybe can to say; Described Bulbus Fritillariae Uninbracteatae is Bulbus Fritillariae Thunbergii, Bulbus Fritillariae Cirrhosae or her shellfish, and should grind into powder with medicinal liquid and take after mixing it with water; Stir-baked SQUAMA MANITIS is ground into powder and is taken after mixing it with water.
Wherein, described pharmaceutical composition is or/and ethanol extraction as active component, adds the preparation that pharmaceutically conventional adjuvant or complementary composition are prepared from taking the medicated powder of crude drug or the water of crude drug.
Wherein, described preparation is oral formulations.
Further, described oral formulations is tablet, pill, drop pill, powder, capsule, soft capsule, granule, oral liquid.
The present invention also provides the preparation method of aforementioned pharmaceutical compositions, and it comprises following operating procedure:
(1) weighting raw materials by weight ratio;
(2) get other medical materials except Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS, after extracting with water or ethanol water, merge extractive liquid,, with together with the medicinal powder of Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS, adds that pharmaceutically conventional adjuvant or complementary composition are prepared into preparation.This side enters to decoct curative effect with wine and increases.
The present invention also provides the purposes of aforementioned pharmaceutical compositions in the medicine of preparation treatment acute mastitis.
Further, described medicine is the medicine of the acute simple mastitis for the treatment of or acute purulent mammitis.
Further, described medicine is the medicine for the treatment of acute mastitis because human milk silt heat-transformation, pyretic toxicity pent up, due to stagnation of QI-blood.Its disease is seen for distending pain of the breast, local Pi Wengao, there is ill-defined scleroma, even local skin is red, swollen, hot, bitterly, there is significantly scleroma, touch a tender spot more very, or companion shiver with cold, high heat, headache, unable, axillary lymph are tied enlargement, red tongue tongue or greasy, Se Bai or Huang, rapid pulse strong or sliding or string.
Generally acknowledged that at present " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " compound compatibility medication is as used military forces " are the most scientific the most several large advantages of the traditional Chinese medical science, wherein " compound compatibility medication is as used military forces " is the original theory of Chinese medicine of very science.Each medicine tight compatibility all linked with one another as arrayed troops for battle in traditional Chinese medical science prescription is its effective means that is better than Western medicine formula.Tcm prescription theory is thought, each prescription, not only need to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical square tube cross too many levels, many target spots and integrate the biological mechanism regulating, the violent suppurative illness of this anxious disease of mastitis is regulated and controled, can obtain than Western medicine more lastingly, therapeutic effect that more green natural has no side effect, and this curative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, prescription of the present invention is just being followed this principle.
In traditional Chinese medical science traditional theory, acute purulent mammitis is because of human milk silt heat-transformation, and pyretic toxicity pents up, the caused acute mastitis of stagnation of QI-blood, disease is seen for distending pain of the breast,, there is ill-defined scleroma in local Pi Wengao, even local skin is red, swollen, hot, bitterly, there is significantly scleroma, touch a tender spot more very, or accompany shiver with cold, high heat, headache, unable, axillary lymph knot enlargement, red tongue tongue or greasy, color is white or yellow, rapid pulse strong or sliding or string etc.The present invention uses the method for heat-clearing and toxic substances removing, promoting flow of QI and blood, lactogenesis eliminating stagnation, expelling pus and toxin by strengthening QI, in pharmaceutical composition of the present invention taking the Herba Taraxaci of being longer than heat-clearing and toxic substances removing as monarch drug, be equipped with ministerial drug Flos Lonicerae, Radix Trichosanthis, Radix Glycyrrhizae uralensis, the Radix Angelicae Dahuricae, the Radix Saposhnikoviae dispelling wind and heat pathogens in left hall, lead to stagnant and send out its knot, making the pyretic toxicity penting up separate and dissipate from passing through inside.Right single removing summer-heat pyretic toxicity, qi depression to blood stasis difficulty disappears, and swollen knot is not loose, therefore be equipped with the ministerial drug Pericarpium Citri Reticulatae promoting qi circulation, resolving food retention in right hall, Olibanum, Myrrha, Radix Angelicae Sinensis, Radix Paeoniae Rubra are with the logical stasis of blood of invigorating blood circulation, reducing swelling and alleviating pain again.Mechanism of qi retardance often can cause liquid to be polymerized to expectorant becoming pus, blockage of the vessel, hard knot forms, therefore send Bulbus Fritillariae Uninbracteatae dissipating phlegm and resolving masses, stir-baked SQUAMA MANITIS, the current venation of Spina Gleditsiae, pyosis heavily fortified point thoroughly, only join the Radix Astragali of being longer than simply auxiliary healthy energy, the saturating pus of poison holding, to rouse oneself healthy energy, assist altogether with Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS, Spina Gleditsiae, the Radix Angelicae Dahuricae that eliminating stagnation is reduced phlegm, the effect of relieving swelling and disintegrating mass, be all the adjuvant drug on left road.And stir-baked SQUAMA MANITIS is good at walking to alter and logical married woman's milk, Fructus Trichosanthis shell is good at the chest stuffiness relieving breast and is gone expectorant knot, Radix Curcumae to be good at dispersing liver-energy and the wide solution breast side of body, therefore the product of this three tastes dredging breast breast are appointed to the adjuvant drug for right wing.Radix Glycyrrhizae uralensis, except having the effect of heat-clearing and toxic substances removing, is more arrogated to oneself coordinating the actions of various ingredients in a prescription, therefore for making medicine.
In above prescription, each group flavour of a drug post is clearly demarcated, complement each other, give full play to the exclusive compound compatibility medication of Chinese medicine as the analyze mentally sexology research methodology marrow of row army as structuring the formation, whether the no matter routed pus of acute mastitis (mastitis), all can make it to dissipate or fast bursting, obtain good efficacy, for clinical application provides a kind of new selection.
Pharmaceutical composition of the present invention can effectively be treated because of human milk silt heat-transformation, and pyretic toxicity pents up, the caused acute mastitis of stagnation of QI-blood or acute purulent mammitis, for clinical application provides a kind of new selection.
Specific embodiment
The preparation of embodiment 1 pharmaceutical composition of the present invention
Get 12 grams of Radix Astragali, 24 grams of Herba Taraxaci dry products, 12 grams of Flos Loniceraes, 8 grams of Bulbus Fritillariae Uninbracteataes, 20 grams of Spina Gleditsiaes, 10 grams of the Radixs Angelicae Dahuricae, 8 grams of Radix Saposhnikoviaes, 10 grams of Olibanums, 10 grams of Myrrhas, 10 grams of Radix Angelicae Sinensis, 10 grams of Radix Paeoniae Rubras, 8 grams of stir-baked SQUAMA MANITISs, 10 grams of Pericarpium Citri Reticulataes, 12 grams of Fructus Trichosanthis shells, 12 grams of Radix Curcumaes, 20 grams of Radix Trichosanthis, 8 grams of Radix Glycyrrhizae uralensiss.Each flavour of a drug take according to quantity, Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS are ground into powder respectively for subsequent use, and all the other each medicinal wine and water half and half decoct.After boiling, thermal transfer is little, then decoct after 10 minutes to 15 minutes, decocting liquid collected; Medicinal residues add water again, wine as method decoct 2 times, merge decocting liquid each time, be blended into Bulbus Fritillariae Uninbracteatae and stir-baked SQUAMA MANITIS end, mix well, obtain decoction.
The preparation of embodiment 2 pharmaceutical compositions of the present invention
Get 9 grams of Radix Astragali, 28 grams of Herba Taraxaci dry products, 15 grams of Flos Loniceraes, 10 grams of Bulbus Fritillariae Uninbracteataes, 24 grams of Spina Gleditsiaes, 13 grams of the Radixs Angelicae Dahuricae, 10 grams of Radix Saposhnikoviaes, 13 grams of Olibanums, 13 grams of Myrrhas, 13 grams of Radix Angelicae Sinensis, 13 grams of Radix Paeoniae Rubra, 10 grams of stir-baked SQUAMA MANITISs, 13 grams of Pericarpium Citri Reticulataes, 15 grams of Fructus Trichosanthis shells, 15 grams of Radix Curcumaes, 24 grams of Radix Trichosanthis, 10 grams of Radix Glycyrrhizae uralensiss.Each flavour of a drug take according to quantity, Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS are ground into powder respectively for subsequent use, and all the other each medicinal wine and water half and half decoct.After boiling, thermal transfer is little, then decoct after 10 minutes to 15 minutes, decocting liquid collected; Medicinal residues add water again, wine as method decoct 2 times, merge decocting liquid each time, be blended into Bulbus Fritillariae Uninbracteatae and stir-baked SQUAMA MANITIS end, mix well, obtain decoction.
The preparation of embodiment 3 pharmaceutical compositions of the present invention
Get 15 grams of Radix Astragali, 20 grams of Herba Taraxaci dry products, 9 grams of Flos Loniceraes, 6 grams of Bulbus Fritillariae Uninbracteataes, 16 grams of Spina Gleditsiaes, 7 grams of the Radixs Angelicae Dahuricae, 6 grams of Radix Saposhnikoviaes, 7 grams of Olibanums, 7 grams of Myrrhas, 7 grams of Radix Angelicae Sinensis, 7 grams of Radix Paeoniae Rubra, 6 grams of stir-baked SQUAMA MANITISs, 7 grams of Pericarpium Citri Reticulataes, 9 grams of Fructus Trichosanthis shells, 9 grams of Radix Curcumaes, 16 grams of Radix Trichosanthis, 6 grams of Radix Glycyrrhizae uralensiss.Each flavour of a drug take according to quantity, Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS are ground into powder respectively for subsequent use, and all the other each medicinal decoctings are endured.After boiling, thermal transfer is little, then decoct after 10 minutes to 15 minutes, decocting liquid collected; Medicinal residues add water as method decoction 2 times again, merge decocting liquid each time, after concentrating, are blended into Bulbus Fritillariae Uninbracteatae and stir-baked SQUAMA MANITIS end, then add appropriate dextrin, soluble starch, mix, and granulate, and obtain granule.
The preparation of embodiment 4 pharmaceutical compositions of the present invention
(1) get 12 grams of Radix Astragali, 48 grams of Herba Taraxaci fresh goods, 12 grams of Flos Loniceraes, 8 grams of Bulbus Fritillariae Uninbracteataes, 20 grams of Spina Gleditsiaes, 10 grams of the Radixs Angelicae Dahuricae, 8 grams of Radix Saposhnikoviaes, 10 grams of Olibanums, 10 grams of Myrrhas, 10 grams of Radix Angelicae Sinensis, 10 grams of Radix Paeoniae Rubras, 8 grams of stir-baked SQUAMA MANITISs, 10 grams of Pericarpium Citri Reticulataes, 12 grams of Fructus Trichosanthis shells, 12 grams of Radix Curcumaes, 20 grams of Radix Trichosanthis, 8 grams of Radix Glycyrrhizae uralensiss.Each flavour of a drug take according to quantity, Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS are ground into powder respectively for subsequent use, and all the other each medicinal wine and water half and half decoct.After boiling, thermal transfer is little, then decoct after 10 minutes to 15 minutes, decocting liquid collected; Medicinal residues add water again, wine as method decoct 2 times, merge decocting liquid each time, be blended into Bulbus Fritillariae Uninbracteatae and stir-baked SQUAMA MANITIS end, mix well, obtain decoction;
(2) get above-mentioned decoction, leave standstill, get supernatant, after concentrating, dry, pulverize, for subsequent use; Get appropriate Macrogol 4000, after melting, above-mentioned medicated powder is added in melting substrate, insulation at 75-85 DEG C; Adopt various pill dripping machine, drip inside/outside footpath and a speed appropriateness, splashed in dimethicone, collects drop pill, obtains drop pill.
Illustrate beneficial effect of the present invention by test example below.
Clinical (outpatient service) treatment situation of test example 1 pharmaceutical composition of the present invention
(1) accept patient's situation for medical treatment
Patient age and sex scope: be mainly adult, be common in nursing women, especially primipara, possesses following symptom feature (possess part, needn't also can not completely all possess), accepts altogether 19 examples for medical treatment.
Symptom feature:
When early stage, be first that patient has local discomfort, feel sometimes a side breast mild pain discomfort, or side shoulder back is sent out heavy, sour swollen discomfort, even lead and the upper arm of this side.Continue and can find nipple discharge (if that discharge is is courageous and upright, serosity should note further inspection when courageous and upright).Again, mammary gland profile changes to some extent, visible lump place cutaneous protuberance, and some local skins are Pericarpium Citri tangerinae shape, even edema, variable color, the change of eczema sample etc.In addition, in breast, can touch the lump of Semen Viciae fabae size, harder, movable.General without obvious pain, minority has paroxysmal dull pain, dull pain or twinge.
Crossed in early days, Ipsilateral breast starts distension, pain, when suckling more so, local Pi Wengao, galactopoiesis is not smooth, and breast caking is not essential, or there is ill-defined scleroma, even local skin is red, swollen, hot, bitterly, there is significantly scleroma, touch a tender spot more very, General Symptoms can be not obvious, or with general malaise, appetite is not good enough, agitation uncomfortable in chest etc.Then, local udder induration, lump increases gradually, now can be with obvious General Symptoms, as hyperpyrexia, shiver with cold, headache, general weakness, be hard and dry etc.Often can in 4～5 days, form abscess, can occur breast throbbing pain, local skin redness, bright.Red tongue tongue or greasy, Se Bai or Huang, rapid pulse is strong, or sliding or string.While becoming pus, the deliquescing of lump central authorities, has fluctuation by it.If, can there is full mammary swelling, pain in breast deep abscess, high heat, but local skin is red and swollen and fluctuate not obviously, need can clarify a diagnosis through puncture.Sometimes abscess can have severally, or successively different times forms, and can wear out skin, or penetrate latex dust, and pus is overflowed from nipple.If treatment is not good at, to miss the season improper, abscess is just likely worn out the front loose connective tissue of pectoralis major fascia, forms retromammary abscess; Or milk overflows from wound place and forms mammary fistula; Can there is pyaemia septica in severe patient.Acute mastitis often, with the enlargement of Ipsilateral axillary gland, has tenderness; Total white blood cells and neutrophilic granulocyte number increase.
(2) treatment standard
Recovery from illness: above-mentioned symptom feature disappears completely, it is abnormal that inspection has no index of correlation.
Evident in efficacy: above-mentioned symptom obviously alleviates, test rating has certain degree to improve simultaneously.
There is certain effect: patient's symptom alleviates to some extent, or index is slightly improved.
Invalid: symptom still, do not improve by index.
(3) Therapeutic Method
1, the made decoction of embodiment 1, each serving with 200 to 400ml, or daily 1 bowl, the rice bowl used of having a meal is taken once every about 6 hours, at least takes every day 3 times, takes according to quantity on time.
2, note also science conditioning daily life, observe some necessary points for attention, as:
(1) avoid human milk silt.Prevent nipple damage, while having damage, will treat in time.Do not allow child form the custom containing nipple sleep.
(2) except avoiding pungent food, delicious food savoury, should eat coarse grain, beans and vegetable more, suitably control the absorption of animal proteinum, note supplementing appropriate trace element simultaneously.Do not eat the curing foods such as brined vegetable, salted egg and bacon as far as possible, can often eat Thallus Laminariae (Thallus Eckloniae) jellied pork skin, have certain softening hardness and resolving stasis effect.
(3), in mastitis onset, breast has red, swollen, hot, pain but while not yet forming abscess, can take following methods auxiliary:
1) emptying milk: in the time feeling mastalgia, swelling even local skin is rubescent, diligent and breast-feed to child, allow child the milk in breast be sucked clean to the greatest extent as far as possible, can use if desired the emptying breast of suction method.When inflammation increases the weight of, hydroderma, hard and hot, be hyacinthine, papilledema.The scleroma of swelling and ache of axillary fossa place, when milking by maneuver, every day, repeatedly each as far as possible that milk is emptying, mammary gland was massaged to dredge gently to nipple direction in available comb back, can ask if desired surgeon to help to massage.
2) partial hot compressing: the hot compress of available heat towel, each 20～30 minutes, every day 3 times to 4 times.
(4) therapeutic outcome
Between many decades, in this patient of medicine composite for curing 19 examples of the present invention, obtain good curative effect.Treatment time, according to the difference of the concrete conditions such as each conditions of patients weight, physical strength and slightly institute's difference, generally can obviously alleviate three or five days left and right symptoms, the person that do not become pus then redness decrescence fades, person is gradually well-done and routed to become pus, by above-mentioned science conditioning daily life, sincerely abide by points for attention, can receive merit.
By above-mentioned treatment standard, in 19 routine patients, there are 13 example recoveries from illness, cure rate is 68.4%; 2 examples are evident in efficacy, are 10.5%; 3 examples have certain effect, are 15.8%; 1 routine DeGrain (invalid), accounts for 5.3%.Total effective rate reaches 94.7%.
Model case
Patient, female, 26 years old, primiparity, prominent sense left breast distension, pain, when suckling, more so, breast seemingly has caking, and galactopoiesis is not smooth, and appetite is not good enough, agitation uncomfortable in chest, general malaise.Continue after, the local hardening of breast, lump is cumulative large, general weakness, aversion to cold, fever, headache.Oral " Ampicillin " antiinflammatory voluntarily, not effect, spends two, and unexpectedly there is throbbing pain in breast, local skin redness, bright, axillary lymph is tied also enlargement, tenderness, asks Chinese traditional medical diagnose so turn.Examine it, patient's chest distending pain, has scleroma, touch a tender spot more very, and local Pi Wengao, red, swollen, hot, bitterly obvious, the enlargement of axillary lymph knot, red tongue with yellow fur, wiry and frequent pulse is strong, is the disease of acute mastitis.After examining, with medicine composite for curing of the present invention (prepared by embodiment 1), and sternly abide by the method for administration of above-mentioned " Therapeutic Method " it " 1 " and the science of " 2 " conditioning and points for attention.Patient takes medicine 2, and symptom has no obvious alleviation, but does not also worsen, and sees its arteries and veins of its inspection of the tongue, and tongue is still ruddy, arteries and veins still along and without inverse image, only add sliding meaning, so advise it to continue to take.Take again 4, ulceration comes to a head unexpectedly, advises its drain, makes it unobstructed, and symptom alleviates day by day since then, and still according to pre-conditioning, symptom disappears finally entirely, increasingly to healing.By having a medical check-up, have no Indexes Abnormality.
Xian fang Huoming Yin, comes from " school note married woman good recipe ", has heat-clearing and toxic substances removing, relieving swelling and disintegrating mass, and effect of promoting blood circulation and stopping pain, can be used for treating mastitis.During early-stage Study, with the positive contrast of Xian fang Huoming Yin, in order to prove the drug activity of pharmaceutical composition of the present invention, result is as follows:
1. within identical treatment time, the cure rate of using pharmaceutical composition of the present invention exceeds 30% than the former side of Xian fang Huoming Yin, and inefficiency is than low 50%(1 Li ︰ 2 examples), this shows that pharmaceutical composition cure rate of the present invention is higher.
2. to after patient's administration of close body constitution, find that the former side's of Xian fang Huoming Yin treatment time is longer 1～3 day than the present invention pharmaceutical composition, this shows that pharmaceutical composition of the present invention is shorter the course for the treatment of.
In sum, pharmaceutical composition of the present invention can effectively be treated because of human milk silt heat-transformation, and pyretic toxicity pents up, the caused acute mastitis of stagnation of QI-blood or acute purulent mammitis, acute simple mastitis, for clinical application provides a kind of new selection.
Claims (8)
1. a pharmaceutical composition for the treatment of acute purulent mammitis, is characterized in that: it is the preparation being prepared from by the crude drug of following weight proportion:
12 parts of the Radixs Astragali, 48 parts of 24 parts of Herba Taraxaci dry products or Herba Taraxaci fresh goods, 12 parts of Flos Loniceraes, 8 parts of Bulbus Fritillariae Uninbracteataes, 20 parts of Spina Gleditsiaes, 10 parts of the Radixs Angelicae Dahuricae, 8 parts of Radix Saposhnikoviaes, 10 parts of Olibanums, 10 parts of Myrrhas, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Paeoniae Rubras, 8 parts of stir-baked SQUAMA MANITISs, 10 parts of Pericarpium Citri Reticulataes, 12 parts of Fructus Trichosanthis shells, 12 parts of Radix Curcumaes, 20 parts of Radix Trichosanthis, 8 parts of Radix Glycyrrhizae uralensiss.
2. pharmaceutical composition according to claim 1, is characterized in that: the described Radix Astragali is Radix Astragali; Described Spina Gleditsiae is for frying Spina Gleditsiae; Described Bulbus Fritillariae Uninbracteatae is Bulbus Fritillariae Thunbergii, Bulbus Fritillariae Cirrhosae or her shellfish.
3. pharmaceutical composition according to claim 1 and 2, is characterized in that: described pharmaceutical composition is or/and ethanol extraction, as active component, adds the preparation that pharmaceutically conventional adjuvant is prepared from taking the medicated powder of crude drug or the water of crude drug.
4. pharmaceutical composition according to claim 3, is characterized in that: described preparation is oral formulations.
5. pharmaceutical composition according to claim 4, is characterized in that: described oral formulations is tablet, pill, powder, capsule, granule, oral liquid.
6. the preparation method of pharmaceutical composition described in claim 1, is characterized in that: it comprises following operating procedure:
(1) weighting raw materials by weight ratio;
(2) get other medical materials except Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS, after extracting with water or ethanol water, merge extractive liquid,, with together with the medicinal powder of Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS, adds that pharmaceutically conventional adjuvant is prepared into preparation.
7. the purposes of pharmaceutical composition in the medicine of preparation treatment acute purulent mammitis described in claim 1-5 any one.
8. purposes according to claim 7, is characterized in that: described medicine is the medicine for the treatment of acute mastitis because human milk silt heat-transformation, pyretic toxicity pent up, due to stagnation of QI-blood.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310123699.6A CN103191370B (en) | 2013-04-10 | 2013-04-10 | Medicine composite for treating mastitis and preparation method and application of medicine composite |
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| CN201310123699.6A CN103191370B (en) | 2013-04-10 | 2013-04-10 | Medicine composite for treating mastitis and preparation method and application of medicine composite |
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| CN103191370A CN103191370A (en) | 2013-07-10 |
| CN103191370B true CN103191370B (en) | 2014-07-23 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103566154A (en) * | 2013-10-23 | 2014-02-12 | 孙斌 | Traditional Chinese medicine for treating acute mastitis |
| CN103751509B (en) * | 2014-01-13 | 2016-02-24 | 黑龙江八一农垦大学 | A kind of herbal composite for the treatment of clinic mastitis |
| CN104189310A (en) * | 2014-08-22 | 2014-12-10 | 严中明 | Composition for treating acute mastitis |
| CN104257911B (en) * | 2014-09-16 | 2018-07-06 | 韩旭 | Pharmaceutical composition and pharmaceutical preparation and its application |
| CN104258031A (en) * | 2014-09-26 | 2015-01-07 | 河南亚卫动物药业有限公司 | Chinese and western medicine compound for preventing and treating recessive mastitis of dairy cows |
| KR20160054668A (en) * | 2014-11-06 | 2016-05-17 | 주식회사 엘지생활건강 | Composition for promoting synthesis of hyaluronic acid comprising Taraxacum herbs extracts and the use thereof |
| CN106552152A (en) * | 2015-09-24 | 2017-04-05 | 戚加井 | A kind of formula for controlling cyclomastopathy |
| CN105213644A (en) * | 2015-11-12 | 2016-01-06 | 青岛友诚高新技术有限公司 | A kind of Chinese medicine preparation for the treatment of acute mastitis and preparation method thereof |
| CN105727242A (en) * | 2016-04-27 | 2016-07-06 | 郑耀玲 | Traditional Chinese medicine preparation for treating internal heat toxin abundant type mastitis and preparing method of traditional Chinese medicine preparation |
| CN105920542A (en) * | 2016-06-25 | 2016-09-07 | 董艳丽 | Chinese medicinal composition for treating acute mastitis |
| CN106214905A (en) * | 2016-08-29 | 2016-12-14 | 周智卿 | A kind of Chinese medicine composition treating mastitis and preparation method thereof |
| CN107362193B (en) * | 2017-07-25 | 2021-05-28 | 上海中医药大学附属曙光医院 | Traditional Chinese medicine composition for preventing and treating initial acute mastitis and preparation method and application thereof |
| CN111514252A (en) * | 2020-06-08 | 2020-08-11 | 首都医科大学附属北京中医医院 | Traditional Chinese medicine composition, medicine, preparation method and application thereof |
| CN114796382A (en) * | 2022-03-29 | 2022-07-29 | 杭州市第三人民医院 | Traditional Chinese medicine composition for treating acute yang syndrome pyocutaneous disease and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953904A (en) * | 2010-09-09 | 2011-01-26 | 闫秋菊 | Milk restriction soup |
| CN101972444A (en) * | 2010-07-13 | 2011-02-16 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating mastitis and preparation method thereof |
-
2013
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972444A (en) * | 2010-07-13 | 2011-02-16 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating mastitis and preparation method thereof |
| CN101953904A (en) * | 2010-09-09 | 2011-01-26 | 闫秋菊 | Milk restriction soup |
Non-Patent Citations (2)
| Title |
|---|
| 急性乳腺炎中医治疗新进展;邢桂琴;《中医药信息》;19960131(第1期);第9页左栏第2-3段 * |
| 邢桂琴.急性乳腺炎中医治疗新进展.《中医药信息》.1996,(第1期),第9-11页. |
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