CN103099882B - Traditional Chinese medicine composition for treating liver qi-stagnation type hyperplasia of mammary glands - Google Patents

Abstract

The invention relates to a traditional Chinese medicine for treating hyperplasia of mammary glands, and particularly relates to a traditional Chinese medicine composition for treating liver qi-stagnation type hyperplasia of mammary glands. The traditional Chinese medicine for treating hyperplasia of mammary glands is prepared from fenugreek, Szechwan chinaberry fruit, radix bupleuri, angelica sinensis, sweet wormwood, Cherokee rose root, radix paeoniae alba, poria cocos, zaocys dhumnade, selfheal, caulis spatholobi, zanthoxylum dissitum hemsl, stiff silkworm and liquorice, wherein the fenugreek can warm the kidney and cultivate the liver so as to strengthen the body resistance to eliminate pathogenic factors; the Szechwan chinaberry fruit can smooth the liver, promote qi circulation and relieve depression; the poria cocos can clear damp and promote diuresis, and promote the body fluid; and the zanthoxylum dissitum hemsl can activate blood and dissipate blood stasis; the four medicines are combined for smoothing the liver, promoting qi, dissipating blood stasis, promoting the body fluid and relieving lump of the breast; the radix bupleuri and the radix paeoniae alba can enhance the function of soothing the liver; the angelica sinensis, the Cherokee rose root, the zaocys dhumnade and the caulis spatholobi can enrich and activate blood and remove extravasated blood; the sweet wormwood and the selfheal can clean deficiency fire, remove swelling and relieve pain; and the liquorice can stop pain and coordinate the drugs. The traditional Chinese medicine has the advantages of being rapid in effectiveness, high in efficiency and cure rate, non-recurrent and non-toxic.

Description

The Chinese medicine composition of the evil qi stagnation type breast hyperplasia for the treatment of liver

Technical field

The present invention relates to a kind of Chinese medicine for the treatment of cyclomastopathy, relate in particular to a kind of Chinese medicine composition for the treatment of the evil qi stagnation type breast hyperplasia of liver.

Background technology

Cyclomastopathy refers to individual event or the multinomial hyperplasia of prostate of breast duct, lobules of mammary gland, acinus epithelium, fibrous tissue.Distending pain of the breast and the multiple lump in breast periodically increasing the weight of of take is main clinical characters.Primary disease is comparatively common, and its sickness rate of domestic report is in 10% left and right, and is mainly in 30～50 years old women, and man also has generation.Primary disease reason is not yet clear and definite so far, mainly thinks at present endocrine dysfunction with human body, particularly relevant with women's ovarian dysfunction.In view of the danger of primary disease canceration exceeds 1.4～2.5 times than healthy women, especially cystic hyperplasia 10%, the 1978 year China of rate average out to of cancerating classifies this disease as breast carcinoma cercinoma prophase pathologic change.Because modern western medicine lacks effective therapy, therefore, the treatment to primary disease, has become one of important topic of Chinese medicine worker current research.

In etiologic etiological discussion, Chinese medicine is always thought, the change of seven emotions so that interior impairment of ZANG FU-organs, and causing disharmony between QI and blood is one of its Etiological.For further its accuracy of checking, once to ill and personality, tongue, arteries and veins and with the square relation of plane such as menstrual cycle, anger, fatigue, to investigate, interrelated data shows, in 270 routine Patients of Mammary Gland Hyperplasias, personality irritability person 199 examples, stringy pulse person 125 examples, account for 62.81%.This explanation personality, pulse condition and primary disease occur closely related.Meanwhile, find that again patient, after premenstrua, angry fatigue, all has in various degree and increases the weight of, this not only illustrates that emotional disorder becomes the Etiological that causes primary disease, and for further control primary disease and reduction sickness rate have searched out an important channel.

Middle ancient Chinese medical classics is summarized the pathogenesis of cyclomastopathy to be described below: the evil Qi-stagnation type of (1) liver, (2) type of hyperactivity of fire caused by deficiency of YIN, (3) Chong and Ren channel disorder type, (4) expectorant stasis of blood type that stagnates.Wherein, the evil Qi-stagnation type of clinical the most commonly liver; Be common in adolescence or course of disease shorter one.Card is shown in melancholy joyless, vexed easily hot-tempered, and both sides distending pain of the breast, can lay one's hand on and arsine piece, and its lump is the growth and decline with the fluctuation of feelings will often, often in premenstrual nipple, distending pain of the breast more very, through after can alleviate to some extent, have two side of body feeling of distension and oppression concurrently, deficiency of QI with disinclination to talk, kind sigh, dim gas is done frequently; Pale tongue, white and thin fur, arteries and veins carrys out stringy and thready pulse.

Summary of the invention

The object of the present invention is to provide a kind of to there is the Chinese medicine composition of significant curative effect by the stagnant cyclomastopathy causing of liver pathogen, i.e. a kind of Chinese medicine composition for the treatment of the evil qi stagnation type breast hyperplasia of liver.

Technical scheme of the present invention:

Treat a Chinese medicine composition for the evil qi stagnation type breast hyperplasia of liver, by the crude drug of following weight parts, formed:

Semen Trigonellae 3-9 part, Fructus Toosendan 6-9 part, Radix Bupleuri 9-12 part, Radix Angelicae Sinensis 10-12 part, Herba Artemisiae Annuae 12-15 part, Radix Rosae Laevigatae 15-20 part, Radix Paeoniae Alba 12-15 part, Poria 15-18 part, Zaocys 9-12 part, Spica Prunellae 12-15 part, Caulis Spatholobi 12-15 part, Fructus Zanthoxyli Dissiti 15-20 part, Bombyx Batryticatus 3-6 part, Radix Glycyrrhizae 9-12 part.

The Chinese medicine composition of the evil qi stagnation type breast hyperplasia for the treatment of liver of the present invention can adopt the conventional preparation method of Chinese medicine to make water preparation, honeyed pill, tablet, powder etc.

The Chinese medicine composition of the evil qi stagnation type breast hyperplasia of above-mentioned treatment liver, preferably adopts following method to be prepared from:

(1) Radix Bupleuri is fried only, the Radix Paeoniae Alba fries only, and pulverizing is 300 orders, obtains component A;

(2) Poria, Radix Glycyrrhizae pulverizing are 300 orders, obtain B component;

(3) get Radix Angelicae Sinensis, Fructus Toosendan, Zaocys, Caulis Spatholobi, Bombyx Batryticatus, Semen Trigonellae and decoct with water 1-1.5h, then with Herba Artemisiae Annuae, Radix Rosae Laevigatae, Spica Prunellae, Fructus Zanthoxyli Dissiti decoct 1.5-2h, filter, concentrated decoction liquor is to sticky paste, obtain component C;

(4) add Mel after component A, B component are mixed with component C and be adjusted to honeyed pill.

The consumption of Chinese medicine composition of the present invention: take crude drug as benchmark, 100-150g, divided and took for 2-4 time every day; It within 10 days, is a course for the treatment of; Anemia of pregnant woman, menstrual period forbid.

The pharmacology analysis of each crude drug that the present invention is used:

Semen Trigonellae: property, temperature; Taste, hardship; Return kidney channel; The kidney warming, cold relieving, pain relieving;

Fructus Toosendan: property, cold; Taste, hardship; Return liver, small intestinal, urinary bladder channel; Soothing liver-QI promoting the circulation of QI to relieve pain;

Radix Bupleuri: property, is slightly cold; Taste, hardship; Return liver, gallbladder meridian; In table solution, soothing the liver;

Radix Angelicae Sinensis: property, temperature; Taste, sweet, pungent; Return liver, the heart, spleen channel; Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving;

Radix Rosae Laevigatae: property, flat; Taste, sour and astringent; Return large intestine channel; In dispelling, invigorate blood circulation, pain relieving, prosperous blood; Herba Artemisiae Annuae: property, is slightly cold; Taste, bitter, pungent; Return liver, gallbladder, kidney channel; Clear deficiency-heat thoroughly, removing heat from blood is except steaming;

The Radix Paeoniae Alba: property, is slightly cold; Taste, bitter, acid, sweet; Return liver, spleen channel; Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating;

Poria: property, flat; Taste is sweet, light; GUIXIN, lung, spleen, kidney channel; Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming;

Zaocys: property, flat; Taste, sweet; Return Liver Channel; Dispel the wind, dredging collateral, relieving convulsion;

Spica Prunellae: property, cold; Taste, bitter, pungent; Return liver, gallbladder meridian; Relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence;

Caulis Spatholobi: property, temperature; Taste, bitter, sweet; Return Liver Channel; Enrich blood, invigorate blood circulation, dredging collateral;

Fructus Zanthoxyli Dissiti: root: promoting blood circulation to remove blood stasis; Son: regulating QI to relieve pain;

Bombyx Batryticatus: property, flat; Taste, salty, pungent; Return liver, lung, stomach warp; Wind-expelling pain-stopping, dissipating phlegm and resolving masses;

Radix Glycyrrhizae: property, flat; Taste, sweet; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

Chinese medicine meridian theory thinks, breast is Yangming Channel feeling pulse institute mistake, and nipple is passed through by the gas of the moon of fainting, therefore the generation of primary disease, main and liver, stomach, punching, times etc. passages through which vital energy circulates in close relations, its cause of disease and seven emotions pent-up, natural endowment is not enough, pica, and the factors such as excess of sexual intercourse are relevant; The stagnant person of liver pathogen, ponders over sorrow, depressed, and secrets is tortuous, haunting.Depressed rage impairing the liver, wood loses bar and reaches, and irritability is taken advantage of, and wreaks havoc insult soil.Spleen is cloudy soil, worry impairing spleen, and again by wood gram, so that transformation failure of spleen, tired in water is wet, the poly-expectorant that forms, knot in mental disorder, in bulk stagnates.

The rule for the treatment of is with strengthening vital QI to eliminate pathogenic factors, and blood circulation promoting and blood stasis dispelling, to regulate the flow of vital energy relieve the pain.In side: Semen Trigonellae, the kidney warming, cold relieving, pain relieving; The kidney being the origin of congenital constitution, and kidney qi foot could be contained edema with the liver involved, then strengthening vital QI to eliminate pathogenic factors; Fructus Toosendan, soothing the liver promoting QI circulation for relieving depression; Poria, promoting diuresis to eliminate damp pathogen, the body fluid of row liver; Fructus Zanthoxyli Dissiti, promoting blood circulation to remove blood stasis, regulating QI to relieve pain; Four medicines are compatible, can depressed liver-energy dispersing and QI regulating, and blood circulation promoting and blood stasis dispelling, the body fluid of row liver stops, the lump of sharp mammary gland.Be aided with that Radix Bupleuri and the Radix Paeoniae Alba are soothing the liver to strengthen, the effect of suppressing the hyperactive liver, easing the affected liver to relieve pain simultaneously; With Radix Angelicae Sinensis, Radix Rosae Laevigatae, enrich blood to invigorate blood circulation and treat congestion and gather not all right; With Zaocys and Caulis Spatholobi acupuncture-stimulating blood stasis dispersing, logical congestion gathers in bulk; With Herba Artemisiae Annuae and the clear asthenic fire of Spica Prunellae, eliminating stagnation, detumescence, with muscle-growing and detumescence, pain relieving; Radix Glycyrrhizae relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

Beneficial effect of the present invention:

Instant effect, effective percentage and cure rate be high, not repeatedly, have no side effect.

The test of pesticide effectiveness of the present invention:

For showing the therapeutic effect of the present invention to the evil qi stagnation type breast hyperplasia of liver, the present invention chooses 400 routine patients through system clinical observation, and 400 routine patients are equally divided into four groups, and four groups of patients are learning processing by statistics aspect sex, age, the state of an illness and the course of disease, no significant difference, has comparability; Wherein three groups is test group, and one group is matched group.Enter group standard: 1) age >=23 year old; 2) sex: female; 3) I or family members' informed consent.

Treatment measure

Test group 1: the water preparation of taking embodiments of the invention 1 preparation; Take crude drug as benchmark, and medication every day 150g, takes at twice, sooner or later respectively once;

Test group 2: the powder of taking embodiments of the invention 2 preparations; Take crude drug as benchmark, and medication every day 100g, divides and takes for 4 times;

Test group 3: the honeyed pill of taking embodiments of the invention 3 preparations; Take crude drug as benchmark, and medication every day 100g, divides 2 to take;

Matched group: take breast peace sheet.

Criterion of therapeutical effect:

Invalid: breast thoroughly instrument detects, and mammary gland tumor and lymph enlargement obviously do not reduce; And pain is without obviously alleviating;

Effective: breast thoroughly instrument detects, and mammary gland tumor and lymph enlargement obviously reduce; Or pain obviously alleviates;

Effective: breast thoroughly instrument detects, and mammary gland tumor and lymph enlargement obviously reduce; And pain obviously alleviates;

Recovery from illness: breast thoroughly instrument detects, and mammary gland tumor and lymph enlargement disappear completely; And without pain.

Respectively the therapeutic effect of test group and matched group is added up, result is as shown in table 1;

Table 1

The effective percentage of test group patient after taking medicine of the present invention 3 days is more than 15%, and the effective percentage of taking after 30 days is 100%, and therefore medicine of the present invention exists the advantage of instant effect.Test group patient took medicine of the present invention after 60 days, and cure rate reaches more than 87%; After taking medicine 180 days, cure rate is 96%; In 3 years, follow up a case by regular visits to, without recurrence; Therefore medicine of the present invention exists that cure rate is high, advantage repeatedly not.

The specific embodiment

Embodiment 1

Get Semen Trigonellae 3g, Fructus Toosendan 6g, Radix Bupleuri 12g, Radix Angelicae Sinensis 10g, Herba Artemisiae Annuae 15g, Radix Rosae Laevigatae 15g, Radix Paeoniae Alba 15g, Poria 15g, Zaocys 12g, Spica Prunellae 15g, Caulis Spatholobi 12g, Fructus Zanthoxyli Dissiti 20g, Bombyx Batryticatus 3g, Radix Glycyrrhizae 12g; Add 1000ml decocting and boil 3 hours, then filter, be concentrated into 300ml, obtain water preparation.

Embodiment 2

Get Semen Trigonellae 3g, Fructus Toosendan 9g, Radix Bupleuri 9g, Radix Angelicae Sinensis 12g, Herba Artemisiae Annuae 15g, Radix Rosae Laevigatae 20g, Radix Paeoniae Alba 15g, Poria 18g, Zaocys 12g, Spica Prunellae 15g, Caulis Spatholobi 15g, Fructus Zanthoxyli Dissiti 20g, Bombyx Batryticatus 6g, Radix Glycyrrhizae 9g; Be crushed to and add 300 orders, fill gets final product to obtain powder.

Embodiment 3

Get Semen Trigonellae 9g, Fructus Toosendan 9g, Radix Bupleuri 12g, Radix Angelicae Sinensis 10g, Herba Artemisiae Annuae 12g, Radix Rosae Laevigatae 20g, Radix Paeoniae Alba 12g, Poria 18g, Zaocys 9g, Spica Prunellae 15g, Caulis Spatholobi 15g, Fructus Zanthoxyli Dissiti 15g, Bombyx Batryticatus 6g, Radix Glycyrrhizae 9g;

(1) Radix Bupleuri is fried only, the Radix Paeoniae Alba fries only, and pulverizing is 300 orders, obtains component A;

(2) Poria, Radix Glycyrrhizae pulverizing are 300 orders, obtain B component;

(5) get Radix Angelicae Sinensis, Fructus Toosendan, Zaocys, Caulis Spatholobi, Bombyx Batryticatus, Semen Trigonellae and add 800ml decocting and boil 1.5h, then with Herba Artemisiae Annuae, Radix Rosae Laevigatae, Spica Prunellae, Fructus Zanthoxyli Dissiti decoct 1.5h, filter, concentrated decoction liquor is to sticky paste, obtain component C;

After component A, B component are mixed with component C, add Mel and be adjusted to honeyed pill.

Claims (1)

1. a Chinese medicine composition for the treatment of the evil qi stagnation type breast hyperplasia of liver, is characterized in that, the weight portion of its crude drug consists of: Semen Trigonellae 3-9 part, Fructus Toosendan 6-9 part, Radix Bupleuri 9-12 part, Radix Angelicae Sinensis 10-12 part, Herba Artemisiae Annuae 12-15 part, Radix Rosae Laevigatae 15-20 part, Radix Paeoniae Alba 12-15 part, Poria 15-18 part, Zaocys 9-12 part, Spica Prunellae 12-15 part, Caulis Spatholobi 12-15 part, Fructus Zanthoxyli Dissiti 15-20 part, Bombyx Batryticatus 3-6 part, Radix Glycyrrhizae 9-12 part;

Adopt following method to be prepared from:

(1) Radix Bupleuri is fried only, the Radix Paeoniae Alba fries only, and pulverizing is 300 orders, obtains component A;

(2) Poria, Radix Glycyrrhizae pulverizing are 300 orders, obtain B component;

(3) get Radix Angelicae Sinensis, Fructus Toosendan, Zaocys, Caulis Spatholobi, Bombyx Batryticatus, Semen Trigonellae and decoct with water 1-1.5h, then with Herba Artemisiae Annuae, Radix Rosae Laevigatae, Spica Prunellae, Fructus Zanthoxyli Dissiti decoct 1.5-2h, filter, concentrated decoction liquor is to sticky paste, obtain component C;

(4) add Mel after component A, B component are mixed with component C and be adjusted to honeyed pill.