CN103191370A - Medicine composite for treating mastitis and preparation method and application of medicine composite - Google Patents

Abstract

The invention provides a pharmaceutical composition for treating mastitis, which is a preparation prepared from raw materials in the following weight proportions: 9-15 parts of astragalus, 20-28 parts of dried dandelion or 40-55 parts of fresh dandelion 9-15 parts of honeysuckle, 6-10 parts of Fritillaria, 16-24 parts of saponins, 7-13 parts of Angelica dahurica, 6-10 parts of Fangfeng, 7-13 parts of frankincense, 7-13 parts of myrrh, angelica tail 7-13 parts, 7-13 parts of red peony root, 6-10 parts of Paoshanjia, 7-13 parts of tangerine peel, 9-15 parts of melon shell, 9-15 parts of turmeric, 16-24 parts of trichosanthes, 6 parts of licorice festival -10 copies. The pharmaceutical composition of the invention can effectively treat mastitis or acute suppurative mastitis caused by milk stasis, heat-toxin accumulation, stagnation of qi and blood, and provides a new choice for clinical medicine.

Description

A kind of pharmaceutical composition for treating mastitis and its preparation method and application

technical field

The invention relates to a pharmaceutical composition for treating mastitis, a preparation method and application thereof.

Background technique

Breast carbuncle refers to the acute suppurative syndrome of red, swollen and painful breasts, poor milk discharge, resulting in pus and carbuncles. It is caused by milk stasis and heat transformation, accumulation of heat and toxins, stagnation of qi and blood. Symptoms are usually breast tenderness, high local skin temperature, induration with unclear boundaries, and even local skin redness, swelling, heat, and pain. More obvious induration, worse tenderness, or accompanied by chills, high fever, headache, weakness, swollen axillary lymph nodes, red or greasy tongue coating, white or yellow in color, strong pulse, slippery or stringy.

Acute suppurative mastitis in modern medicine belongs to the category of mastitis. It is an acute suppurative infection of the breast and is a common disease in the puerperium. It is more common in breastfeeding women, especially primiparous women at the beginning of breastfeeding. The causes of the disease are, one is due to the accumulation of milk, and the other is because of the invasion of bacteria. The cause of milk stasis may be that the nipple is too small or sunken, which hinders breastfeeding; or because the mother has too much milk, and the mother does not empty the excess milk in the breast in time; or because the milk duct is blocked, the milk duct itself has inflammation, tumor or external Compression can lead to blocked milk ducts. In addition, the fibers shed from the bra can also block the milk ducts, resulting in blocked milk ducts. Bacterial invasion is common with Staphylococcus aureus. Mastitis is very harmful, and severe cases may be complicated by systemic suppurative infection. At the beginning, the breast is swollen, painful, with lumps and tenderness, the surface is red and swollen, and fever, and then the symptoms aggravate, and the breast is throbbing pain, which may be accompanied by high fever, chills, irritability, headache, fatigue, dry stool, etc. The lower lymph nodes are swollen and tender. If the treatment is not timely or inappropriate, the abscess can penetrate the loose connective tissue in front of the pectoralis major fascia to form a retromammary abscess, or milk overflows from the wound to form galactorrhea, and even sepsis can occur.

Since mastitis is more common in breast-feeding women, if Western medicine is given, it will have adverse effects on breastfeeding infants, so most of them recommend traditional Chinese medicine for treatment. Most of the traditional Chinese medicines are natural plants, and the traditional Chinese medicines for the treatment of this disease are completely optional prescriptions for those with mild medicinal properties, which will not have adverse effects on breastfeeding. Even for patients who do not breastfeed, the use of large doses of antibiotics to treat this disease will also bring about the problem of "drug-resistant bacteria", while Chinese medicine has the advantage of avoiding many toxic and side effects caused by the use of large amounts of antibiotics in Western medicine.

Contents of the invention

The object of the present invention is to provide a pharmaceutical composition for treating mastitis, its preparation method and application.

The invention provides a pharmaceutical composition for treating mastitis, which is a preparation prepared from raw materials with the following weight ratio:

Astragalus 9-15 parts, 20-28 parts of dried dandelion or 40-55 parts of fresh dandelion, 9-15 parts of honeysuckle, 6-10 parts of Fritillaria, 16-24 parts of saponins, 7-13 parts of Angelica dahurica, Fangfeng 6-10 parts, 7-13 parts of frankincense, 7-13 parts of myrrh, 7-13 parts of angelica tail, 7-13 parts of red peony, 6-10 parts of Paoshanjia, 7-13 parts of tangerine peel, 9 parts of melon shell -15 parts, turmeric 9-15 parts, trichosanthes 16-24 parts, licorice festival 6-10 parts.

Further, it is a preparation prepared from raw materials with the following weight ratio:

12 parts of astragalus, 24 parts of dried dandelion or 48 parts of fresh dandelion, 12 parts of honeysuckle, 8 parts of fritillaria, 20 parts of saponins, 10 parts of angelica, 8 parts of wind, 10 parts of frankincense, 10 parts of myrrh, angelica tail 10 parts, 10 parts of red peony, 8 parts of paoshanjia, 10 parts of tangerine peel, 12 parts of melon shell, 12 parts of turmeric, 20 parts of trichosanthes, and 8 parts of licorice festival.

Wherein, said Radix Astragali is raw Radix Astragali; said Saponaria thorn is fried Saponaria thorn, and the medicinal effect of the raw product is greatly reduced, or it can be said to be basically ineffective; The powder is taken after mixing with the medicine liquid; Paoshanjia is ground into powder and taken after mixing.

Wherein, the pharmaceutical composition is a preparation prepared by taking the powder of the crude drug, or the water or/and ethanol extract of the crude drug as the active component, and adding commonly used pharmaceutical excipients or auxiliary components.

Wherein, the preparation is an oral preparation.

Further, the oral preparations are tablets, pills, dropping pills, powders, capsules, soft capsules, granules, and oral liquids.

The present invention also provides a preparation method of the above-mentioned pharmaceutical composition, which comprises the following steps:

(1) Weigh the raw material medicine according to the weight ratio;

(2) Take the medicinal materials other than Fritillaria and Paoshanjia, extract them with water or ethanol aqueous solution, combine the extracts, add the medicinal materials powder of Fritillaria and Paoshanjia, and add commonly used pharmaceutical excipients or auxiliary materials The ingredients are prepared into formulations. Adding wine into the decoction of this prescription greatly increases the curative effect.

The present invention also provides the application of the above pharmaceutical composition in the preparation of medicine for treating mastitis.

Further, the medicine is a medicine for treating acute simple mastitis or acute suppurative mastitis.

Further, the medicament is a medicament for treating mastitis caused by stagnation of milk into heat, accumulation of heat and toxin, and stagnation of Qi and blood. Symptoms are breast distending pain, high local skin temperature, and induration with unclear boundaries, or local skin redness, swelling, heat, pain, more obvious induration, more tenderness, or accompanied by chills, high fever, headache, Weakness, swollen axillary lymph nodes, red tongue or greasy coating, white or yellow color, strong or slippery or stringy pulse.

At present, it has been recognized that "holistic concept", "treatment based on syndrome differentiation", "compound use", and "combination of compound medicines is like using soldiers" are the most scientific and effective advantages of traditional Chinese medicine. Original theory of medicine. The interlocking and tight compatibility of the various medicines in the prescription of traditional Chinese medicine is an effective means that it is superior to the formula of western medicine. The theory of traditional Chinese medicine prescriptions believes that each prescription not only needs to be properly compatible with the appropriate drugs according to the etiology and pathogenesis, but also should conform to the basic structure of the prescription, that is, the theory of prescription compatibility of "lord, minister, assistant, and envoy", the so-called " The prescription compatibility of "jun, minister, assistant, and envoy" is a scientific ratio based on an all-round judgment of the pathogenesis of the disease. TCM prescriptions can regulate mastitis, an acute and severe suppurative disease, through the biological mechanism of multi-link and multi-target integrated regulation, and can achieve a longer-lasting, greener, natural and non-toxic treatment effect than western medicine. This curative effect is based on the correct guidance of the above-mentioned traditional Chinese medicine original theory, and the composition of the present invention has followed this principle.

In the traditional theory of traditional Chinese medicine, acute suppurative mastitis is mastitis caused by stagnant milk, accumulation of heat and toxin, stagnation of qi and blood. Induration, or even local skin redness, swelling, heat, pain, more obvious induration, more tenderness, or accompanied by chills, high fever, headache, weakness, swollen axillary lymph nodes, red or greasy tongue coating, white or yellow color, The pulse is strong or slippery or stringy. The present invention uses the methods of clearing heat and detoxifying, promoting qi and blood circulation, clearing milk and dispelling stagnation, and removing pus. Jie, Angelica, and Fangfeng evacuate wind-heat, unblock stagnation and send out its knots, so that the accumulated heat and poison can be dissipated from the outside. However, if the antipyretic and antipyretic drugs alone are used, the qi stagnation and blood stasis will be difficult to eliminate, and the swelling will not dissipate. Therefore, it is combined with the ministerial medicine of the right hall, tangerine peel, to promote qi stagnation, frankincense, myrrh, angelica tail, and red peony to promote blood circulation and remove blood stasis. Reduce swelling and relieve pain. Qi blockage can cause liquid to gather into phlegm and pus, veins to block, and hard knots to form. Therefore, Fritillaria is sent to resolve phlegm and disperse stagnation. Raw astragalus, which assists righteousness, relieves poison and penetrates pus, invigorates righteousness, and works together with Fritillaria, Paoshania, Saponaria thorn, and Angelica dahurica to dissipate stagnation, reduce phlegm, reduce swelling and ulcers, and is also an adjuvant for the left. Paoshanjia is good at walking and clearing women's milk, Gualou shell is good at widening breasts and removing phlegm knots, turmeric is good at soothing liver qi and loosening breasts and flanks, so these three flavors are used as adjuvant medicine for the right way . In addition to the effect of clearing away heat and detoxifying, licorice festival is also good at reconciling various medicines, so it is used as a medicine.

In the above prescriptions, each group of medicines has distinct roles and functions, and complements each other, giving full play to the essence of speculative scientific research methodology unique to traditional Chinese medicine. No, it can be dissipated or quickly collapsed, and a good curative effect can be obtained, which provides a new option for clinical medication.

The pharmaceutical composition of the invention can effectively treat mastitis or acute suppurative mastitis caused by milk stasis, heat-toxin accumulation, stagnation of qi and blood, and provides a new choice for clinical medicine.

specific embodiment

The preparation of embodiment 1 pharmaceutical composition of the present invention

Take 12 grams of raw astragalus, 24 grams of dried dandelion, 12 grams of honeysuckle, 8 grams of fritillaria, 20 grams of saponins, 10 grams of angelica, 8 grams of wind, 10 grams of frankincense, 10 grams of myrrh, 10 grams of angelica tail, red 10 grams of peony, 8 grams of Paoshanjia, 10 grams of tangerine peel, 12 grams of melon shell, 12 grams of turmeric, 20 grams of trichosanthin, and 8 grams of licorice festival. Weigh each herbal flavor according to the amount, grind Fritillaria and Paoshanjia into powder for later use, and boil the rest of the medicinal wine and water in half. After boiling, reduce the heat to a low level, fry for another 10 to 15 minutes, and collect the decoction; add water and wine to the dregs and decoct twice in the same way, combine each decoction, and add Fritillaria and Paoshanjia powder , and mix thoroughly to get the decoction.

The preparation of embodiment 2 pharmaceutical composition of the present invention

Take 9 grams of raw astragalus, 28 grams of dried dandelion, 15 grams of honeysuckle, 10 grams of Fritillaria, 24 grams of saponins, 13 grams of Angelica dahurica, 10 grams of Fangfeng, 13 grams of frankincense, 13 grams of myrrh, 13 grams of angelica tail, 13 grams of peony root, 10 grams of Paoshanjia, 13 grams of tangerine peel, 15 grams of melon shell, 15 grams of turmeric, 24 grams of trichosanthes, and 10 grams of licorice section. Weigh each herbal flavor according to the amount, grind Fritillaria and Paoshanjia into powder for later use, and boil the rest of the medicinal wine and water in half. After boiling, reduce the heat to a low level, fry for another 10 to 15 minutes, and collect the decoction; add water and wine to the dregs and decoct twice in the same way, combine each decoction, and add Fritillaria and Paoshanjia powder , and mix thoroughly to get the decoction.

The preparation of embodiment 3 pharmaceutical composition of the present invention

Take 15 grams of raw astragalus, 20 grams of dried dandelion, 9 grams of honeysuckle, 6 grams of Fritillaria, 16 grams of saponins, 7 grams of Angelica dahurica, 6 grams of Fangfeng, 7 grams of frankincense, 7 grams of myrrh, 7 grams of angelica tail, 7 grams of peony, 6 grams of Paoshanjia, 7 grams of tangerine peel, 9 grams of melon shell, 9 grams of turmeric, 16 grams of trichosanthin, and 6 grams of licorice festival. Each herbal medicine is weighed according to the amount, and the Fritillaria and Paoshania are respectively ground into powder for later use, and the rest of the medicines are boiled in water. After boiling, reduce the heat to a low level, fry for another 10 to 15 minutes, and then collect the decoction; add water to the medicinal residue and decoct twice as in the same way, combine each decoction, concentrate, add Fritillaria and Paoshania At the end, add an appropriate amount of dextrin and soluble starch, mix well, and granulate to obtain granules.

Embodiment 4 Preparation of the pharmaceutical composition of the present invention

(1) Take 12 grams of raw astragalus, 48 grams of fresh dandelion, 12 grams of honeysuckle, 8 grams of Fritillaria, 20 grams of saponins, 10 grams of Angelica dahurica, 8 grams of Fangfeng, 10 grams of frankincense, 10 grams of myrrh, and 10 grams of angelica tail. 10 grams of red peony, 8 grams of paoshanjia, 10 grams of tangerine peel, 12 grams of melon shell, 12 grams of turmeric, 20 grams of trichosanthin, and 8 grams of licorice festival. Weigh each herbal flavor according to the amount, grind Fritillaria and Paoshanjia into powder for later use, and boil the rest of the medicinal wine and water in half. After boiling, reduce the heat to a low level, fry for another 10 to 15 minutes, and collect the decoction; add water and wine to the dregs and decoct twice in the same way, combine each decoction, and add Fritillaria and Paoshanjia powder , and mix thoroughly to get the decoction;

(2) Take the above decoction, let it stand still, take the supernatant, concentrate, dry, crush, and set aside; take an appropriate amount of polyethylene glycol 4000, after melting, add the above powder into the molten matrix, and keep warm at 75-85°C ;Using various types of dropping pill machines, the inner/outer diameter of the dropping port and the dropping speed are moderate, drop it into simethicone oil, collect the dropping pills, and obtain the dropping pills.

The beneficial effects of the present invention will be specifically described below through test examples.

Clinical (outpatient) treatment situation of test example 1 pharmaceutical composition of the present invention

(1) Situation of admitted patients

Age and gender range of patients: mainly adults, common in breastfeeding women, especially primiparous women, with the following symptoms and characteristics (some of them are sufficient, not all of them are necessary and impossible), and a total of 19 cases were treated.

Symptom characteristics:

In the early stage, the first thing is that the patient feels local discomfort, and sometimes feels mild pain and discomfort on one side of the breast, or heaviness, soreness and discomfort on one side of the shoulder and back, and even pulls the upper arm on that side. Next, nipple discharge can be found (if the discharge is bloody or serous bloody, further examination should be paid attention to). Thirdly, the shape of the mammary gland has changed, and the skin at the tumor can be seen to be raised, and some local skin is orange-peel-like, and even edema, discoloration, and eczema-like changes. In addition, there is a palpable broad bean-sized lump in the breast, which is hard and movable. Generally, there is no obvious pain, and a few have paroxysmal dull pain, dull pain or tingling pain.

After the early stage, the breast on the affected side begins to be full and painful, especially during breastfeeding. The local skin temperature is high, the milk secretion is not smooth, breast lumps are optional, or induration with unclear boundaries appears, and even local skin redness and swelling , heat, pain, more obvious induration, more tenderness, systemic symptoms may not be obvious, or accompanied by general malaise, poor appetite, chest tightness and irritability, etc. Then, the local breast hardens and the mass gradually increases. At this time, it may be accompanied by obvious systemic symptoms, such as high fever, chills, headache, general weakness, and dry stool. An abscess can often form within 4 to 5 days, and there may be throbbing pain in the breast, local redness and swelling of the skin, and translucent. The tongue is red or greasy, white or yellow in color, and the pulse is strong, slippery or stringy. When pus is formed, the center of the lump becomes soft, and there is a sense of fluctuation when pressed. If it is a deep breast abscess, there may be swelling, pain, and high fever of the whole breast, but the local skin redness and fluctuation are not obvious, and a puncture is required to confirm the diagnosis. Sometimes there may be several abscesses, or they may form in different periods, which may penetrate the skin or penetrate into the milk duct, causing pus to overflow from the nipple. If the treatment is not good and the time is wrong, the abscess may penetrate the loose connective tissue in front of the pectoralis major fascia, forming a mammary abscess; or milk overflows from the wound to form galactorrhea; severe cases may cause sepsis. Acute mastitis is often accompanied by enlarged and tender axillary lymph nodes on the affected side; the total number of white blood cells and neutrophils increases.

(2) Standards of treatment

Recovery: the above-mentioned symptoms and characteristics completely disappeared, and no abnormalities in relevant indicators were found in the examination.

Significant curative effect: the above symptoms were significantly relieved, and the test indicators were improved to a considerable extent.

There is a certain effect: the patient's symptoms are alleviated, or the indicators are slightly improved.

Invalid: Symptoms remain, indicators have not improved.

(3) Treatment methods

1. Take the decoction prepared in Example 1, take 200 to 400ml each time, or take 1 bowl of rice bowl for daily meals, take it every 6 hours or so, take it at least 3 times a day, take it on time and according to the amount.

2. Pay attention to and scientifically regulate daily life, and observe some necessary precautions, such as:

(1) Avoid milk stasis. Prevent nipple damage, and treat it in time when there is damage. Don't let your child get into the habit of sleeping with the nipple on.

(2) In addition to avoiding spicy, fat, sweet and thick flavors, eat more coarse grains, beans and vegetables, properly control the intake of animal protein, and pay attention to supplementing appropriate amounts of trace elements. Try not to eat salted vegetables, salted eggs, bacon and other pickled products. You can often eat kelp meat jelly, which has a certain effect of softening firmness and removing blood stasis.

(3) At the initial onset of mastitis, that is, when the breast is red, swollen, hot, and painful but has not yet formed an abscess, the following methods can be used to assist:

1) Empty milk: When you feel breast pain, swelling or even local skin redness, you should breastfeed your child frequently, let the child suck the milk in the breast as much as possible, and empty the breast by suction if necessary. When the inflammation is aggravated, the skin is edematous, hard and hot, purple-blue in color, and the nipples are edematous. There is swelling, pain and induration in the armpit. When expressing milk by hand, several times a day, try to empty the milk each time. You can gently massage the back of the comb toward the nipple to dredge the mammary gland. If necessary, you can ask a surgeon to help massage.

2) Local hot compress: hot towel can be used for hot compress, 20-30 minutes each time, 3 to 4 times a day.

(4) Treatment results

Nineteen cases of patients with this disease have been treated with the pharmaceutical composition of the present invention for decades, and better curative effect has been obtained. The treatment time varies slightly according to the specific conditions of each patient, such as the severity of the disease and the strength of the body. Generally, the symptoms can be significantly relieved in about three to five days. If it is overcooked and collapsed, according to the above-mentioned scientific regulation of daily life, follow the precautions, and you can get all the results.

According to the above treatment standards, 13 of the 19 patients were cured, with a cure rate of 68.4%; 2 cases had a significant effect, accounting for 10.5%; 3 cases had a certain effect, accounting for 15.8%; 1 case had no obvious effect (ineffective), accounting for 5.3%. The total effective rate is 94.7%.

Typical cases

The patient, female, 26 years old, primiparous, suddenly felt fullness and pain in the left breast, especially when breastfeeding, the breast seemed to have lumps, the milk secretion was not smooth, the appetite was poor, chest tightness and irritability, and general discomfort. Afterwards, the breasts became hard locally, the lumps gradually increased, general weakness, chills, fever, and headaches. I took "Ambison" orally for anti-inflammatory by myself, but it didn't work. After two days, my breasts developed throbbing pain, local skin was red, swollen and translucent, and my axillary lymph nodes were also swollen and tender, so I referred to Chinese medicine for diagnosis and treatment. Diagnosed, the patient's breasts are distended and painful, with induration, tenderness is worse, local skin temperature is high, redness, swelling, heat, pain are obvious, axillary lymph nodes are swollen, red tongue with yellow coating, strong pulse strings, it is the symptom of mastitis. disease. After diagnosis, treat with the pharmaceutical composition of the present invention (prepared in Example 1), and strictly abide by the medication method of "1" and the scientific conditioning and precautions of "2" of the above "treatment method". The patient took the medicine for 2 days, and the symptoms did not show obvious relief, but they did not worsen. The pulse was checked by observing his tongue. After taking it for another 4 days, the pus was ruptured, and it was instructed to drain to make it unobstructed. Since then, the symptoms have been alleviated day by day, and the treatment is still as before, and the symptoms finally disappear completely and tend to heal day by day. After physical examination, no abnormal indicators were found.

Xianfang Huomingyin, from "Xiaozhu Women's Good Prescriptions", has the effects of clearing heat and detoxifying, reducing swelling and ulceration, promoting blood circulation and relieving pain, and can be used to treat mastitis. During the preliminary research period, Xianfang Huomingyin was used as a positive control to prove the efficacy and activity of the pharmaceutical composition of the present invention. The results are as follows:

①In the same treatment time, the recovery rate of using the pharmaceutical composition of the present invention is 30% higher than that of the original prescription of Xianfang Huomingyin, while the ineffective rate is 50% lower than that (1 case: 2 cases), which shows that this The inventive pharmaceutical composition has a higher cure rate.

② After administration to patients with similar constitutions, it was found that the treatment time of the original prescription of Xianfang Huomingyin was 1-3 days longer than that of the pharmaceutical composition of the present invention, which indicated that the course of treatment of the pharmaceutical composition of the present invention was shorter.

In summary, the pharmaceutical composition of the present invention can effectively treat mastitis or acute suppurative mastitis and acute simple mastitis caused by milk stasis and heat transformation, accumulation of heat and toxins, stagnation of Qi and blood, and provides a good foundation for clinical use. A new option.

Claims (10)

1. pharmaceutical composition for the treatment of mastitis, it is characterized in that: it is the preparation that is prepared from by following materials of weight proportions medicine:

Radix Astragali 9-15 part, 40～55 parts of the bright product of Herba Taraxaci dry product 20-28 part or Herba Taraxaci, Flos Lonicerae 9-15 part, Bulbus Fritillariae Uninbracteatae 6-10 part, Spina Gleditsiae 16-24 part, Radix Angelicae Dahuricae 7-13 part, Radix Saposhnikoviae 6-10 part, Olibanum 7-13 part, Myrrha 7-13 part, Radix Angelicae Sinensis 7-13 part, Radix Paeoniae Rubra 7-13 part, stir-baked SQUAMA MANITIS 6-10 part, Pericarpium Citri Reticulatae 7-13 part, Fructus Trichosanthis shell 9-15 part, Radix Curcumae 9-15 part, Radix Trichosanthis 16-24 part, Radix Glycyrrhizae uralensis 6-10 part.

2. pharmaceutical composition according to claim 1, it is characterized in that: it is the preparation that is prepared from by following materials of weight proportions medicine:

12 parts of the Radixs Astragali, 48 parts of the bright product of 24 parts of Herba Taraxaci dry products or Herba Taraxaci, 12 parts of Flos Loniceraes, 8 parts of Bulbus Fritillariae Uninbracteataes, 20 parts of Spina Gleditsiaes, 10 parts of the Radixs Angelicae Dahuricae, 8 parts of Radix Saposhnikoviaes, 10 parts of Olibanums, 10 parts of Myrrhas, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Paeoniae Rubras, 8 parts of stir-baked SQUAMA MANITISs, 10 parts of Pericarpium Citri Reticulataes, 12 parts of Fructus Trichosanthis shells, 12 parts of Radix Curcumaes, 20 parts of Radix Trichosanthis, 8 parts of Radix Glycyrrhizae uralensiss.

3. pharmaceutical composition according to claim 1 and 2, it is characterized in that: the described Radix Astragali is Radix Astragali; Described Spina Gleditsiae is for frying Spina Gleditsiae; Described Bulbus Fritillariae Uninbracteatae is Bulbus Fritillariae Thunbergii, Bulbus Fritillariae Cirrhosae or her shellfish.

4. according to any described pharmaceutical composition of claim 1-3, it is characterized in that: described pharmaceutical composition be with the water of the medicated powder of crude drug or crude drug or/and ethanol extraction is active component, add the preparation that adjuvant pharmaceutically commonly used or complementary composition are prepared from.

5. pharmaceutical composition according to claim 4, it is characterized in that: described preparation is oral formulations.

6. pharmaceutical composition according to claim 5, it is characterized in that: described oral formulations is tablet, pill, drop pill, powder, capsule, soft capsule, granule, oral liquid.

7. the described preparation of drug combination method of claim 1, it is characterized in that: it comprises following operating procedure:

(1) weighting raw materials by weight ratio;

(2) get other medical materials except Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS, after extracting with water or ethanol water, merge extractive liquid, with the medicinal powder of Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS, adds that adjuvant or complementary composition pharmaceutically commonly used are prepared into preparation.

8. the purposes of any described pharmaceutical composition of claim 1-6 in the medicine of preparation treatment acute mastitis.

9. purposes according to claim 8 is characterized in that: described medicine is the medicine of the acute simple mastitis for the treatment of or acute festering type mastitis.

10. purposes according to claim 8 is characterized in that: described medicine is treatment because human milk silt heat-transformation, pyretic toxicity pent up, the medicine of acute mastitis due to the stagnation of QI-blood.