CN103191370A - Medicine composite for treating mastitis and preparation method and application of medicine composite - Google Patents
Medicine composite for treating mastitis and preparation method and application of medicine composite Download PDFInfo
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Abstract
The invention provides a medicine composite for treating mastitis. The medicine composite is prepared from the following medicinal raw materials in parts by weight: 9-15 parts of astragalus, 20-28 parts of dried taraxacum or 40-55 parts of fresh taraxacum, 9-15 parts of honeysuckle, 6-10 parts of fritillaria, 16-24 parts of spina gleditsiae, 7-13 parts of dahurian angelica root, 6-10 parts of radix saposhnikoviae, 7-13 parts of olibanum, 7-13 parts of myrrh, 7-13 parts of radix angelicae sinensis, 7-13 parts of red peony root, 6-10 parts of stir-fried pangolin scales, 7-13 parts of tangerine peel, 9-15 parts of sankegourd fruit shell, 9-15 parts of turmeric root tuber, 16-24 parts of radices trichosanthis and 6-10 parts of licorice section. The medicine composite can be used for effectively treating mammary abscess or acute suppurative mastitis due to heat transformed from milk deposition, toxic heat accumulation and qi and blood stagnation and supplies a new choice to clinical medication.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of mastitis and its production and use.
Background technology
Acute mastitis means the breast congestion and swelling pain, and milk is discharged not smooth, so that ties the acute festering type disease that pus becomes carbuncle.System is because of the human milk silt heat-transformation, and pyretic toxicity pents up, stagnation of QI-blood causes, disease opinion is generally distending pain of the breast, local Pi Wengao, ill-defined scleroma occurs, even local skin is red, swollen, hot, bitterly, more significantly scleroma occurs, touch a tender spot more very, or companion shiver with cold, high heat, headache, unable, axillary lymph knot enlargement, red tongue tongue or be bored with Se Bai or Huang, rapid pulse is strong, or sliding or string.
The acute festering type mastitis of modern medicine belong to the acute mastitis category, and it is the acute festering type infection of breast, is the puerperal commonly encountered diseases, is more common in the nursing women, and particularly the primipara is the most multiple in the incipient stage of suckling.Its pathogenic factor, the one, because the alluvial of milk, the 2nd, because the intrusion of antibacterial.The reason of human milk silt then can or be caved in because of hypomastia, hinders suckling; Or because of hypergalactosis, and the puerpera is not in time with unnecessary milk emptying in the breast; Or obstructed because of latex dust, latex dust itself has inflammation, tumor or external compressing, all can cause latex dust obstructed, and in addition, the fiber that medicated bra comes off also can stop up latex dust, causes obstructed.The intrusion of antibacterial is common with staphylococcus aureus.Mastitis harm is very big, and severe patient can concurrent general pyogenic infection.It is time-out just, and mammary swelling, pain have lump and tenderness, and the surface is red and swollen, heating, and the then sx that continues, breast is throbbing pain, can accompany hyperpyrexia, shiver with cold, agitation, headache, weak, dry stool knot etc., the enlargement of Ipsilateral axillary lymph knot, tenderness.If the untimely or malpractice for the treatment of, its abscess can be worn out loose connective tissue before the pectoralis major fascia, forms retromammary abscess, or milk overflows from the wound place and form mammary fistula, and very pyaemia septica can take place the person.
Because the women that acute mastitis is mainly in age of sucking if give Western medicine, to the adverse effect that nourished the baby on mother's milk, therefore mostly advises Chinese medicine.Most Chinese medicines are natural plants, and the complete not high violent person's prescription of drug of choice of the Chinese medicine for the treatment of primary disease, can not produce harmful effect to breast feeding.Even if need not breastfeeding patient, use heavy dose of antibiotic therapy primary disease, also can bring " fastbacteria problem ", the traditional Chinese medical science then has evades the advantage that doctor trained in Western medicine is used many toxic and side effects that a large amount of antibiotic bring.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of mastitis and its production and use.
The invention provides a kind of pharmaceutical composition for the treatment of mastitis, it is the preparation that is prepared from by following materials of weight proportions medicine:
Radix Astragali 9-15 part, 40～55 parts of the bright product of Herba Taraxaci dry product 20-28 part or Herba Taraxaci, Flos Lonicerae 9-15 part, Bulbus Fritillariae Uninbracteatae 6-10 part, Spina Gleditsiae 16-24 part, Radix Angelicae Dahuricae 7-13 part, Radix Saposhnikoviae 6-10 part, Olibanum 7-13 part, Myrrha 7-13 part, Radix Angelicae Sinensis 7-13 part, Radix Paeoniae Rubra 7-13 part, stir-baked SQUAMA MANITIS 6-10 part, Pericarpium Citri Reticulatae 7-13 part, Fructus Trichosanthis shell 9-15 part, Radix Curcumae 9-15 part, Radix Trichosanthis 16-24 part, Radix Glycyrrhizae uralensis 6-10 part.
Further, it is the preparation that is prepared from by following materials of weight proportions medicine:
12 parts of the Radixs Astragali, 48 parts of the bright product of 24 parts of Herba Taraxaci dry products or Herba Taraxaci, 12 parts of Flos Loniceraes, 8 parts of Bulbus Fritillariae Uninbracteataes, 20 parts of Spina Gleditsiaes, 10 parts of the Radixs Angelicae Dahuricae, 8 parts of Radix Saposhnikoviaes, 10 parts of Olibanums, 10 parts of Myrrhas, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Paeoniae Rubras, 8 parts of stir-baked SQUAMA MANITISs, 10 parts of Pericarpium Citri Reticulataes, 12 parts of Fructus Trichosanthis shells, 12 parts of Radix Curcumaes, 20 parts of Radix Trichosanthis, 8 parts of Radix Glycyrrhizae uralensiss.
Wherein, the described Radix Astragali is Radix Astragali; Described Spina Gleditsiae is given birth to the product drug effect and is subtracted greatly for frying Spina Gleditsiae, and it is invalid substantially maybe can to say; Described Bulbus Fritillariae Uninbracteatae is Bulbus Fritillariae Thunbergii, Bulbus Fritillariae Cirrhosae or her shellfish, and should grind into powder with medicinal liquid and take after mixing it with water; Stir-baked SQUAMA MANITIS is ground into powder and is taken after mixing it with water.
Wherein, described pharmaceutical composition be with the water of the medicated powder of crude drug or crude drug or/and ethanol extraction is active component, add the preparation that adjuvant pharmaceutically commonly used or complementary composition are prepared from.
Wherein, described preparation is oral formulations.
Further, described oral formulations is tablet, pill, drop pill, powder, capsule, soft capsule, granule, oral liquid.
The present invention also provides the preparation method of aforementioned pharmaceutical compositions, and it comprises following operating procedure:
(1) weighting raw materials by weight ratio;
(2) get other medical materials except Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS, after extracting with water or ethanol water, merge extractive liquid, with the medicinal powder of Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS, adds that adjuvant or complementary composition pharmaceutically commonly used are prepared into preparation.This side goes into to fry in shallow oil curative effect with wine heightens.
The present invention also provides the purposes of aforementioned pharmaceutical compositions in the medicine of preparation treatment acute mastitis.
Further, described medicine is the medicine of the acute simple mastitis for the treatment of or acute festering type mastitis.
Further, described medicine is treatment because human milk silt heat-transformation, pyretic toxicity pent up, the medicine of acute mastitis due to the stagnation of QI-blood.Its disease is seen and is distending pain of the breast, local Pi Wengao, ill-defined scleroma appears, even local skin is red, swollen, hot, bitterly, more significantly scleroma appears, touches a tender spot more very, or companion shiver with cold, high heat, headache, unable, axillary lymph are tied enlargement, red tongue tongue or greasy, Se Bai or Huang, rapid pulse strong or sliding or string.
Generally acknowledged that at present " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " the compound compatibility medication is as using military forces " are the most effective several big advantages of science of the traditional Chinese medical science, wherein " the compound compatibility medication is as using military forces " is the original theory of Chinese medicine of very science.Each medicine tight compatibility all linked with one another as arraying troops for battle in the traditional Chinese medical science prescription is its effective means that is better than the Western medicine prescription.The tcm prescription theory is thought, each prescription, not only need to select the suitable appropriate compatibility of medicine according to etiology and pathogenesis, the basic structure that also should meet prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical square tube cross too many levels, many target spots and integrate the biological mechanism of regulating, the violent suppurative illness of this anxious disease of mastitis is regulated and control, can obtain, the more green natural therapeutic effect that have no side effect more lasting than Western medicine, and this curative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, and prescription of the present invention is just being followed this principle.
In traditional Chinese medical science traditional theory, the acute festering type mastitis are because of the human milk silt heat-transformation, and pyretic toxicity pents up, the caused acute mastitis of stagnation of QI-blood, disease is seen and is distending pain of the breast, ill-defined scleroma appears in local Pi Wengao, even local skin is red, swollen, hot, bitterly, more significantly scleroma appears, touch a tender spot more very, or accompany shiver with cold, high heat, headache, unable, axillary lymph knot enlargement, red tongue tongue or greasy, color is white or yellow, rapid pulse strong or sliding or string etc.The present invention uses the method for heat-clearing and toxic substances removing, promoting flow of QI and blood, lactogenesis eliminating stagnation, expelling pus and toxin by strengthening QI, be monarch drug with the Herba Taraxaci of being longer than heat-clearing and toxic substances removing in the pharmaceutical composition of the present invention, be equipped with ministerial drug Flos Lonicerae, Radix Trichosanthis, Radix Glycyrrhizae uralensis, the Radix Angelicae Dahuricae, the Radix Saposhnikoviae dispelling wind and heat pathogens in left hall, lead to stagnant and its knot, make the pyretic toxicity that pents up separate dissipation from passing through inside.Right single removing summer-heat pyretic toxicity, then the qi depression to blood stasis difficulty disappears, and swollen knot does not loose, so be equipped with the ministerial drug Pericarpium Citri Reticulatae promoting qi circulation, resolving food retention in right hall again, Olibanum, Myrrha, Radix Angelicae Sinensis, Radix Paeoniae Rubra are with the logical stasis of blood of invigorating blood circulation, reducing swelling and alleviating pain.Mechanism of qi retardance whenever can cause liquid to gather into expectorant becoming pus, blockage of the vessel, hard knot forms, so send the Bulbus Fritillariae Uninbracteatae dissipating phlegm and resolving masses, stir-baked SQUAMA MANITIS, the current venation of Spina Gleditsiae, saturating pyosis heavily fortified point, only join the Radix Astragali of being longer than auxiliary healthy energy, the saturating pus of poison holding simply, to rouse oneself healthy energy, assist altogether with Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS, Spina Gleditsiae, the Radix Angelicae Dahuricae that eliminating stagnation is reduced phlegm, the effect of relieving swelling and disintegrating mass, be all the adjuvant drug on left road.And stir-baked SQUAMA MANITIS is good at walking to scurry and logical married woman's milk, and Fructus Trichosanthis shell is good at the chest stuffiness relieving breast and is gone expectorant knot, Radix Curcumae to be good at dispersing liver-energy and the wide solution breast side of body, so product of this three flavors mediation breast breast are appointed adjuvant drug for right wing.Radix Glycyrrhizae uralensis is more arrogated to oneself coordinating the actions of various ingredients in a prescription except the effect with heat-clearing and toxic substances removing, so for making medicine.
In the above prescription, it is clearly demarcated that each organizes the flavour of a drug post, complement each other, given full play to the sexology research methodology marrow of analyzing mentally as the exclusive compound compatibility medication of Chinese medicine is structured the formation as row army, whether no matter acute mastitis (mastitis) burst pus, all can make it to dissipate or fast bursting, obtain good efficacy, for clinical application provides a kind of new selection.
Pharmaceutical composition of the present invention can effectively be treated because of the human milk silt heat-transformation, and pyretic toxicity pents up, the caused acute mastitis of stagnation of QI-blood or acute festering type mastitis, for clinical application provides a kind of new selection.
Specific embodiment
Embodiment 1 preparation of drug combination of the present invention
Get Radix Astragali 12 grams, Herba Taraxaci dry product 24 grams, Flos Lonicerae 12 grams, Bulbus Fritillariae Uninbracteatae 8 grams, Spina Gleditsiae 20 grams, the Radix Angelicae Dahuricae 10 grams, Radix Saposhnikoviae 8 grams, Olibanum 10 grams, Myrrha 10 grams, Radix Angelicae Sinensis 10 grams, Radix Paeoniae Rubra 10 grams, stir-baked SQUAMA MANITIS 8 grams, Pericarpium Citri Reticulatae 10 grams, Fructus Trichosanthis shell 12 grams, Radix Curcumae 12 grams, Radix Trichosanthis 20 grams, Radix Glycyrrhizae uralensis 8 grams.Each flavour of a drug takes by weighing according to quantity, Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS is ground into powder respectively standby, and all the other each medicinal wine and water half and half decoct.After boiling that thermal transfer is little, fry in shallow oil 10 minutes to 15 minutes again after, collect decocting liquid; Medicinal residues Jia Shui, wine such as method again decoct 2 times, merge each time decocting liquid, are blended into Bulbus Fritillariae Uninbracteatae and stir-baked SQUAMA MANITIS end, mix well, and namely get decoction.
Embodiment 2 preparation of drug combination of the present invention
Get Radix Astragali 9 grams, Herba Taraxaci dry product 28 grams, Flos Lonicerae 15 grams, Bulbus Fritillariae Uninbracteatae 10 grams, Spina Gleditsiae 24 grams, the Radix Angelicae Dahuricae 13 grams, Radix Saposhnikoviae 10 grams, Olibanum 13 grams, Myrrha 13 grams, Radix Angelicae Sinensis 13 grams, Radix Paeoniae Rubra 13 grams, stir-baked SQUAMA MANITIS 10 grams, Pericarpium Citri Reticulatae 13 grams, Fructus Trichosanthis shell 15 grams, Radix Curcumae 15 grams, Radix Trichosanthis 24 grams, Radix Glycyrrhizae uralensis 10 grams.Each flavour of a drug takes by weighing according to quantity, Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS is ground into powder respectively standby, and all the other each medicinal wine and water half and half decoct.After boiling that thermal transfer is little, fry in shallow oil 10 minutes to 15 minutes again after, collect decocting liquid; Medicinal residues Jia Shui, wine such as method again decoct 2 times, merge each time decocting liquid, are blended into Bulbus Fritillariae Uninbracteatae and stir-baked SQUAMA MANITIS end, mix well, and namely get decoction.
Embodiment 3 preparation of drug combination of the present invention
Get Radix Astragali 15 grams, Herba Taraxaci dry product 20 grams, Flos Lonicerae 9 grams, Bulbus Fritillariae Uninbracteatae 6 grams, Spina Gleditsiae 16 grams, the Radix Angelicae Dahuricae 7 grams, Radix Saposhnikoviae 6 grams, Olibanum 7 grams, Myrrha 7 grams, Radix Angelicae Sinensis 7 grams, Radix Paeoniae Rubra 7 grams, stir-baked SQUAMA MANITIS 6 grams, Pericarpium Citri Reticulatae 7 grams, Fructus Trichosanthis shell 9 grams, Radix Curcumae 9 grams, Radix Trichosanthis 16 grams, Radix Glycyrrhizae uralensis 6 grams.Each flavour of a drug takes by weighing according to quantity, Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS is ground into powder respectively standby, and all the other each medicinal decoctings are endured.After boiling that thermal transfer is little, fry in shallow oil 10 minutes to 15 minutes again after, collect decocting liquid; Medicinal residues add water again such as method decocts 2 times, merge each time decocting liquid, after concentrating, are blended into Bulbus Fritillariae Uninbracteatae and stir-baked SQUAMA MANITIS end, add an amount of dextrin, soluble starch again, and mixing is granulated, and namely gets granule.
Embodiment 4 preparation of drug combination of the present invention
(1) gets Radix Astragali 12 grams, bright product 48 grams of Herba Taraxaci, Flos Lonicerae 12 grams, Bulbus Fritillariae Uninbracteatae 8 grams, Spina Gleditsiae 20 grams, the Radix Angelicae Dahuricae 10 grams, Radix Saposhnikoviae 8 grams, Olibanum 10 grams, Myrrha 10 grams, Radix Angelicae Sinensis 10 grams, Radix Paeoniae Rubra 10 grams, stir-baked SQUAMA MANITIS 8 grams, Pericarpium Citri Reticulatae 10 grams, Fructus Trichosanthis shell 12 grams, Radix Curcumae 12 grams, Radix Trichosanthis 20 grams, Radix Glycyrrhizae uralensis 8 grams.Each flavour of a drug takes by weighing according to quantity, Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS is ground into powder respectively standby, and all the other each medicinal wine and water half and half decoct.After boiling that thermal transfer is little, fry in shallow oil 10 minutes to 15 minutes again after, collect decocting liquid; Medicinal residues Jia Shui, wine such as method again decoct 2 times, merge each time decocting liquid, are blended into Bulbus Fritillariae Uninbracteatae and stir-baked SQUAMA MANITIS end, mix well, and namely get decoction;
(2) get above-mentioned decoction, leave standstill, get supernatant, after concentrating, drying is pulverized, and is standby; Get an amount of Macrogol 4000, after the fusion, above-mentioned medicated powder is added in the fusion substrate, 75-85 ℃ of insulation down; Adopt various drop pill machine, the drip inside/outside directly reaches and drips the speed appropriateness, and it is splashed in the dimethicone, collects drop pill, namely gets drop pill.
Below specify beneficial effect of the present invention by testing example.
Clinical (outpatient service) treatment situation of test example 1 pharmaceutical composition of the present invention
(1) accepts patient's situation for medical treatment
Patient age and sex scope: be mainly the adult, be common in the nursing women, especially the primipara possesses following symptom feature (possess part and get final product, needn't also can not fully all possess), accepts 19 examples altogether for medical treatment.
Symptom feature:
When early stage, at first be that the patient has local discomfort, feel a side breast mild pain discomfort sometimes, or that side shoulder back is sent out heavy, acid is expanded is uncomfortable, even lead and the upper arm of this side.Continue and then can find nipple discharge (if discharge is courage and uprightness, should notes further inspection when serosity is courageous and upright).Again, the mammary gland profile changes to some extent, visible lump place cutaneous protuberance, and the local skin that has is the Pericarpium Citri tangerinae shape, even edema, variable color, the change of eczema sample etc.In addition, can touch the lump of Semen Viciae fabae size in the breast, harder, movable.General no obvious pain, minority has paroxysmal dull pain, dull pain or twinge.
Crossed in early days, the Ipsilateral breast begins distension, pain, during suckling more so, local Pi Wengao, galactopoiesis is not smooth, and the breast caking is not essential, or ill-defined scleroma appears, even local skin is red, swollen, hot, bitterly, more significantly scleroma appears, touches a tender spot more very, General Symptoms can be not obvious, or with general malaise, appetite is not good enough, agitation uncomfortable in chest etc.Then, local udder induration, lump increases gradually, and this moment can be with tangible General Symptoms, as hyperpyrexia, shiver with cold, headache, general weakness, be hard and dry etc.Often can in 4～5 days, form abscess, the breast throbbing pain can occur, the local skin redness, bright.Red tongue tongue or greasy, Se Bai or Huang, rapid pulse is strong, or sliding or string.The deliquescing of lump central authorities has fluctuation by it when becoming pus.If the swelling of full milk room, pain can appear in the breast deep abscess, high heat, but local skin is red and swollen and fluctuate not obviously, needs can clarify a diagnosis through puncture.Sometimes abscess can have several, or successively different times forms, and can wear out skin, or penetrate latex dust, and pus is overflowed from nipple.If treatment is not good at, it is improper to miss the season, and abscess just might be worn out the preceding loose connective tissue of pectoralis major fascia, forms retromammary abscess; Or milk overflows from the wound place and forms mammary fistula; Pyaemia septica can take place in severe patient.Acute mastitis often with the enlargement of Ipsilateral axillary gland, has tenderness; Total white blood cells and neutrophilic granulocyte number increase.
(2) treatment standard
Recovery from illness: the complete obiteration of above-mentioned symptom characteristics, check does not see that index of correlation is unusual.
Evident in efficacy: above-mentioned symptom obviously alleviates, and test rating has certain degree to improve simultaneously.
Certain effect is arranged: patient's symptom alleviates to some extent, or index has improvement slightly.
Invalid: symptom remains unchanged, and index not to be improved.
(3) Therapeutic Method
1, embodiment 1 made decoction takes 200 to 400ml at every turn, or daily 1 bowl in the used rice bowl of having a meal, and takes once every about 6 hours, obeys at least every day 3 times, takes according to quantity on time.
2, note also science conditioning daily life, observe some necessary points for attention, as:
(1) avoids human milk silt.Prevent the nipple damage, will in time treat when damage is arranged.Do not allow child form and contain the custom that nipple is slept.
(2) except avoiding pungent food, the delicious food savoury, should eating coarse grain, beans and vegetable more, suitably control the absorption of animal proteinum, note replenishing an amount of trace element simultaneously.Do not eat curing foods such as brined vegetable, salted egg and bacon as far as possible, can often eat the Thallus Laminariae (Thallus Eckloniae) jellied pork skin, certain softening hardness and resolving stasis effect is arranged.
(3) in mastitis were just sent out, namely breast had red, swollen, hot, bitterly but when not forming abscess as yet, can take following method to assist:
1) emptying milk: when feeling that mastalgia, swelling even local skin are rubescent, diligent and breast-feed to child, to allow child the milk in the breast be sucked clean to the greatest extent as far as possible, in case of necessity available suction method emptying breast.When inflammation increases the weight of, hydroderma, hard and hot, be hyacinthine, papilledema.The scleroma of swelling and ache of axillary fossa place, when milking with maneuver, every day, repeatedly each mammary gland was massaged to dredge gently to the nipple direction in available comb back as far as possible with the milk emptying, can ask the surgeon to help to massage in case of necessity.
2) local hot compress: the hot compress of available heat towel, each 20～30 minutes, every day 3 times to 4 times.
(4) therapeutic outcome
In this patient of medicine composite for curing 19 examples of the present invention, obtained curative effect preferably between many decades.Treatment time, difference according to the difference of concrete conditions such as each conditions of patients weight, physical strength and slightly to some extent, generally can obviously alleviate three or five days left and right sides symptoms, the person that do not become pus redness then decrescence fades, the person is well-done and routed gradually to become pus, by above-mentioned science conditioning daily life, sincerely abide by points for attention, can receive merit.
By above-mentioned treatment standard, among the 19 routine patients, 13 example recoveries from illness are arranged, cure rate is 68.4%; 2 examples are evident in efficacy, are 10.5%; 3 examples have certain effect, are 15.8%; 1 routine DeGrain (invalid) accounts for 5.3%.Total effective rate reaches 94.7%.
Model case
The patient, the woman, 26 years old, primiparity, prominent sense left breast distension, pain, more so, breast seemingly has caking during suckling, and galactopoiesis is not smooth, and appetite is not good enough, agitation uncomfortable in chest, general malaise.Continue after, the local hardening of breast, lump is cumulative big, general weakness, aversion to cold, fever, headache.Oral " Ampicillin " antiinflammatory is not voluntarily imitated, and spends two, and throbbing pain appears in breast unexpectedly, local skin redness, bright, and axillary lymph is tied also enlargement, tenderness, asks Chinese traditional medical diagnose so change.Examine it, the patient's chest distending pain has scleroma, touch a tender spot more very, and local Pi Wengao, red, swollen, hot, obvious bitterly, the enlargement of axillary lymph knot, red tongue with yellow fur, wiry and frequent pulse is strong, is the disease of acute mastitis.After examining, with medicine composite for curing of the present invention (embodiment 1 preparation), and sternly abide by the method for administration of above-mentioned " Therapeutic Method " it " 1 " and science conditioning and the points for attention of " 2 ".The patient took medicine 2, and symptom is not seen obvious alleviation, but also worsened, and saw its arteries and veins of its inspection of the tongue, and tongue is still ruddy, arteries and veins still along and do not have inverse image, only add sliding meaning, so advise it to continue to take.Obeyed again 4, ulceration comes to a head unexpectedly, advises its drain, makes it unobstructed, and symptom alleviates day by day since then, and still according to pre-conditioning, symptom disappears finally entirely, day by day to healing.By having a medical check-up, do not see that index is unusual.
Xian fang Huoming Yin comes from " married woman's good recipe is annotated in the school ", has heat-clearing and toxic substances removing, relieving swelling and disintegrating mass, and the effect of promoting blood circulation and stopping pain can be used for treating mastitis.During the early-stage Study, with the positive contrast of Xian fang Huoming Yin, in order to prove the drug activity of pharmaceutical composition of the present invention, the result is as follows:
1. in identical treatment time, the cure rate of using pharmaceutical composition of the present invention exceeds 30% than the former side of Xian fang Huoming Yin, and inefficiency is then than low 50%(1 Li ︰ 2 examples), this shows that pharmaceutical composition cure rate of the present invention is higher.
2. after the patient's administration to close body constitution, find that the former side's of Xian fang Huoming Yin treatment time is longer 1～3 day than the present invention pharmaceutical composition, this shows that pharmaceutical composition of the present invention is shorter the course for the treatment of.
In sum, pharmaceutical composition of the present invention can effectively be treated because of the human milk silt heat-transformation, and pyretic toxicity pents up, the caused acute mastitis of stagnation of QI-blood or acute festering type mastitis, acute simple mastitis, for clinical application provides a kind of new selection.
Claims (10)
1. pharmaceutical composition for the treatment of mastitis, it is characterized in that: it is the preparation that is prepared from by following materials of weight proportions medicine:
Radix Astragali 9-15 part, 40～55 parts of the bright product of Herba Taraxaci dry product 20-28 part or Herba Taraxaci, Flos Lonicerae 9-15 part, Bulbus Fritillariae Uninbracteatae 6-10 part, Spina Gleditsiae 16-24 part, Radix Angelicae Dahuricae 7-13 part, Radix Saposhnikoviae 6-10 part, Olibanum 7-13 part, Myrrha 7-13 part, Radix Angelicae Sinensis 7-13 part, Radix Paeoniae Rubra 7-13 part, stir-baked SQUAMA MANITIS 6-10 part, Pericarpium Citri Reticulatae 7-13 part, Fructus Trichosanthis shell 9-15 part, Radix Curcumae 9-15 part, Radix Trichosanthis 16-24 part, Radix Glycyrrhizae uralensis 6-10 part.
2. pharmaceutical composition according to claim 1, it is characterized in that: it is the preparation that is prepared from by following materials of weight proportions medicine:
12 parts of the Radixs Astragali, 48 parts of the bright product of 24 parts of Herba Taraxaci dry products or Herba Taraxaci, 12 parts of Flos Loniceraes, 8 parts of Bulbus Fritillariae Uninbracteataes, 20 parts of Spina Gleditsiaes, 10 parts of the Radixs Angelicae Dahuricae, 8 parts of Radix Saposhnikoviaes, 10 parts of Olibanums, 10 parts of Myrrhas, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Paeoniae Rubras, 8 parts of stir-baked SQUAMA MANITISs, 10 parts of Pericarpium Citri Reticulataes, 12 parts of Fructus Trichosanthis shells, 12 parts of Radix Curcumaes, 20 parts of Radix Trichosanthis, 8 parts of Radix Glycyrrhizae uralensiss.
3. pharmaceutical composition according to claim 1 and 2, it is characterized in that: the described Radix Astragali is Radix Astragali; Described Spina Gleditsiae is for frying Spina Gleditsiae; Described Bulbus Fritillariae Uninbracteatae is Bulbus Fritillariae Thunbergii, Bulbus Fritillariae Cirrhosae or her shellfish.
4. according to any described pharmaceutical composition of claim 1-3, it is characterized in that: described pharmaceutical composition be with the water of the medicated powder of crude drug or crude drug or/and ethanol extraction is active component, add the preparation that adjuvant pharmaceutically commonly used or complementary composition are prepared from.
5. pharmaceutical composition according to claim 4, it is characterized in that: described preparation is oral formulations.
6. pharmaceutical composition according to claim 5, it is characterized in that: described oral formulations is tablet, pill, drop pill, powder, capsule, soft capsule, granule, oral liquid.
7. the described preparation of drug combination method of claim 1, it is characterized in that: it comprises following operating procedure:
(1) weighting raw materials by weight ratio;
(2) get other medical materials except Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS, after extracting with water or ethanol water, merge extractive liquid, with the medicinal powder of Bulbus Fritillariae Uninbracteatae, stir-baked SQUAMA MANITIS, adds that adjuvant or complementary composition pharmaceutically commonly used are prepared into preparation.
8. the purposes of any described pharmaceutical composition of claim 1-6 in the medicine of preparation treatment acute mastitis.
9. purposes according to claim 8 is characterized in that: described medicine is the medicine of the acute simple mastitis for the treatment of or acute festering type mastitis.
10. purposes according to claim 8 is characterized in that: described medicine is treatment because human milk silt heat-transformation, pyretic toxicity pent up, the medicine of acute mastitis due to the stagnation of QI-blood.
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103566154A (en) * | 2013-10-23 | 2014-02-12 | 孙斌 | Traditional Chinese medicine for treating acute mastitis |
| CN103751509A (en) * | 2014-01-13 | 2014-04-30 | 黑龙江八一农垦大学 | Chinese herbal medicine composition for treating clinical mastitis |
| CN104189310A (en) * | 2014-08-22 | 2014-12-10 | 严中明 | Composition for treating acute mastitis |
| CN104257911A (en) * | 2014-09-16 | 2015-01-07 | 韩旭 | Pharmaceutical composition, pharmaceutical preparation and application thereof |
| CN104258031A (en) * | 2014-09-26 | 2015-01-07 | 河南亚卫动物药业有限公司 | Chinese and western medicine compound for preventing and treating recessive mastitis of dairy cows |
| CN105213644A (en) * | 2015-11-12 | 2016-01-06 | 青岛友诚高新技术有限公司 | A kind of Chinese medicine preparation for the treatment of acute mastitis and preparation method thereof |
| CN105582036A (en) * | 2014-11-06 | 2016-05-18 | 株式会社Lg生活健康 | Composition for promoting synthesis of hyaluronic acid comprising Taraxacum herbs extracts and the use thereof |
| CN105727242A (en) * | 2016-04-27 | 2016-07-06 | 郑耀玲 | Traditional Chinese medicine preparation for treating internal heat toxin abundant type mastitis and preparing method of traditional Chinese medicine preparation |
| CN105920542A (en) * | 2016-06-25 | 2016-09-07 | 董艳丽 | Chinese medicinal composition for treating acute mastitis |
| CN106214905A (en) * | 2016-08-29 | 2016-12-14 | 周智卿 | A kind of Chinese medicine composition treating mastitis and preparation method thereof |
| CN106552152A (en) * | 2015-09-24 | 2017-04-05 | 戚加井 | A kind of formula for controlling cyclomastopathy |
| CN107362193A (en) * | 2017-07-25 | 2017-11-21 | 上海中医药大学附属曙光医院 | Chinese medicine composition of preventing and treating acute mastitis at initial stage and its preparation method and application |
| CN111514252A (en) * | 2020-06-08 | 2020-08-11 | 首都医科大学附属北京中医医院 | Traditional Chinese medicine composition, medicine, preparation method and application thereof |
| CN114796382A (en) * | 2022-03-29 | 2022-07-29 | 杭州市第三人民医院 | Traditional Chinese medicine composition for treating acute yang syndrome pyocutaneous disease and application thereof |
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| CN103751509A (en) * | 2014-01-13 | 2014-04-30 | 黑龙江八一农垦大学 | Chinese herbal medicine composition for treating clinical mastitis |
| CN103751509B (en) * | 2014-01-13 | 2016-02-24 | 黑龙江八一农垦大学 | A kind of herbal composite for the treatment of clinic mastitis |
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| CN105582036A (en) * | 2014-11-06 | 2016-05-18 | 株式会社Lg生活健康 | Composition for promoting synthesis of hyaluronic acid comprising Taraxacum herbs extracts and the use thereof |
| CN106552152A (en) * | 2015-09-24 | 2017-04-05 | 戚加井 | A kind of formula for controlling cyclomastopathy |
| CN105213644A (en) * | 2015-11-12 | 2016-01-06 | 青岛友诚高新技术有限公司 | A kind of Chinese medicine preparation for the treatment of acute mastitis and preparation method thereof |
| CN105727242A (en) * | 2016-04-27 | 2016-07-06 | 郑耀玲 | Traditional Chinese medicine preparation for treating internal heat toxin abundant type mastitis and preparing method of traditional Chinese medicine preparation |
| CN105920542A (en) * | 2016-06-25 | 2016-09-07 | 董艳丽 | Chinese medicinal composition for treating acute mastitis |
| CN106214905A (en) * | 2016-08-29 | 2016-12-14 | 周智卿 | A kind of Chinese medicine composition treating mastitis and preparation method thereof |
| CN107362193A (en) * | 2017-07-25 | 2017-11-21 | 上海中医药大学附属曙光医院 | Chinese medicine composition of preventing and treating acute mastitis at initial stage and its preparation method and application |
| CN107362193B (en) * | 2017-07-25 | 2021-05-28 | 上海中医药大学附属曙光医院 | Traditional Chinese medicine composition for preventing and treating initial acute mastitis and preparation method and application thereof |
| CN111514252A (en) * | 2020-06-08 | 2020-08-11 | 首都医科大学附属北京中医医院 | Traditional Chinese medicine composition, medicine, preparation method and application thereof |
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