CN104258031A - Chinese and western medicine compound for preventing and treating recessive mastitis of dairy cows - Google Patents
Chinese and western medicine compound for preventing and treating recessive mastitis of dairy cows Download PDFInfo
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Abstract
The invention belongs to the field of biotechnologies of dairy cow veterinary drugs, and particularly relates to a Chinese and western medicine compound for preventing and treating recessive mastitis of dairy cows. The compound is prepared from the following Chinese and western medicinal materials by weight: 10-15g of levamisole hydrochloride, 25-30g of taurine, 55-60g of honeysuckle, 45-50g of angelica sinensis, 25-30g of orange peel, 15-20g of radix saposhnikoviae, 15-20g of radix angelicae, 20-25g of fritillaria thun-bergli, 20-25g of frankincense, 20-25g of myrrh, 25-30g of radix paeoniae rubra, 15-20g of manis pentadactyla and 10-15g of liquorice. The Chinese and western medicine compound for preventing and treating recessive mastitis of dairy cows is prepared on the basis of years of clinical experience, has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis and eliminating swelling to promote lactation, and has the advantages of being residue-free, pollution-free, environment-friendly, safe, simple in production process and convenient to use.
Description
Technical field
The invention belongs to milch cow veterinary drug biological technical field, be specifically related to a kind of Chinese medicine and western medicine complex preventing and treating bovine subclinical mastitis.
Background technology
Mammitis of cow is the inflammatory diseases of a kind of mammary glandular cell and mammary gland interstitial.From the cause of disease, cause the pathogen of breast inflammation of milk cattle, about 85% is streptococcus, micrococcus scarlatinae etc., and 5% is staphylococcus, and other have tubercule bacillus, Brucella, corynebacterium pyogenes, escherichia coli, mycoplasmas and mycete etc.The economy that mammitis of cow causes is often comparatively large, is first that milk yield reduces, is secondly that disease breast can not be drunk, even gives people's communicate illness, work the mischief to people ' s health.The consumer of modern society is to the requirement of milk mainly safety, nutrition and fresh, and safety occupy space of top prominence, and the attention rate thus for milch cow relevant disease is also higher.
Bovine subclinical mastitis (Subclinical Mastitis), also known as Subclinical mastitis, a kind of a kind of mastitis without clinical symptoms performance.It is characterized in that breast and milk without naked eyes as seen extremely, but milk changes on physicochemical property, bacteriology.Bovine subclinical mastitis is a kind of common disease that puzzlement dairy industry is produced, it not only can cause the milk yield of ill milch cow to decline, and also has a huge impact the quality of milk, causes dairy fat content to reduce, lactoprotein Quality Down, lactose content reduces and dry matter content declines.These changes will cause pasture produce raw material milk oeverall quality decline, cause serious economic loss, also can extend the time of milch cow post-partum estrus, very harmful to dairy.If latent mammitis can not be treated in time, often make cow breast atrophy, milk can not be sold, and even completely loses Lactation, and the work tool therefore carrying out control mastitis is of great significance.
The sickness rate of China's mammitis of cow is very high, and the sickness rate of latent mammitis is higher, hazardness is larger.According to the statistics of international milch cow community, 20 century 70s, the sickness rate of mammitis of cow is 2%, and latent mammitis prevalence is 50%.In China, the same period, the recall rate of several big cities latent mammitis was 20% 70%.The eighties in 20th century, there is the milk cattle of more than 60% all to infect and have latent mammitis, have the newborn district of 30% 50% to infect and have latent mammitis.
For bovine subclinical mastitis, in prior art, although use the antibiotics such as sulfonamides, furans to treat comparatively fast, but there is the drawback of longevity of residure length in these medicines, milk can not be drunk in a short time, causes and wastes in a large number simultaneously, also bring very large economic loss.In the market except preventing and treating except bovine subclinical mastitis by antibiotic, some are also had to contain breast perfusion preparation or the liniment of medicinal herb components, although these medicaments can play the effect of control latent mammitis, but often there is complex manufacturing, use loaded down with trivial details drawback, thus wait further improvement.
Summary of the invention
The object of the invention is to provide a kind of Chinese medicine and western medicine complex for preventing and treating bovine subclinical mastitis, and this complex has that preparation is simple, easy to use, the advantage such as have no side effect, and is suitable for use in the latent mammitis of control milk cow in lactation period.
The technical solution used in the present invention is as follows.
Prevent and treat a Chinese medicine and western medicine complex for bovine subclinical mastitis, form by following Chinese medicine and western medicine raw material is composite, weight proportion ratio is; levamisole hydrochloride 10 ~ 15g, taurine 25 ~ 30g, Flos Lonicerae 55 ~ 60g; Radix Angelicae Sinensis 45 ~ 50g, Pericarpium Citri Reticulatae 25 ~ 30g, Radix Saposhnikoviae 15 ~ 20g; the Radix Angelicae Dahuricae 15 ~ 20g, Bulbus Fritillariae Uninbracteatae 20 ~ 30g, Olibanum 20 ~ 30g; Myrrha 20 ~ 30g; Radix Paeoniae Rubra 25 ~ 30g, Squama Manis 15 ~ 20g, Radix Glycyrrhizae 10 ~ 20g.
The Chinese medicine and western medicine complex of described control bovine subclinical mastitis, more excellent proportioning is, levamisole hydrochloride 13g; taurine 28g, Flos Lonicerae 58g, Radix Angelicae Sinensis 48g; Pericarpium Citri Reticulatae 28g, Radix Saposhnikoviae 18g, Radix Angelicae Dahuricae 18g; Bulbus Fritillariae Uninbracteatae 28g; Olibanum 28g, Myrrha 28g, Radix Paeoniae Rubra 28g; Squama Manis 18g, Radix Glycyrrhizae 18g.The Chinese medicine and western medicine complex of described control bovine subclinical mastitis, for prevention or treatment bovine subclinical mastitis.
The Chinese medicine and western medicine complex of described control bovine subclinical mastitis, during for preventing bovine subclinical mastitis, uses in the Lactation of Dairy Cow phase, by every every day 200g consumption make an addition in basal diet, use 15 days continuously.
The Chinese medicine and western medicine complex of described control bovine subclinical mastitis, when being used for the treatment of bovine subclinical mastitis, uses in the Lactation of Dairy Cow phase, by every every day 300g consumption make an addition in basal diet, continuously use 15 days.
The Chinese medicine and western medicine complex of described control bovine subclinical mastitis, its preparation method is, after first each Chinese crude drug being dried or dried, takes in proportion, pulverizes 60 ~ 80 mesh sieves, and then add the mixing of Western medicine levamisole hydrochloride in proportion, subpackage completes.
Chinese herbal medicine comes from food, and being taken from natural animal, plant, mineral etc., and maintaining their natural structure and biological activity, is the most acceptive pure natural substance of animal body.Generally speaking, Chinese medicine can regulate the immune function of body, improve the activity of natural killer cell (NK cell) and promote the generation of interleukin II, promote the phagocytic function of macrophage (M Φ), stimulate and activate T, bone-marrow-derived lymphocyte, attract the polymorph neutrophile leucocytes (PMN) in peripheral blood to enter infection site, engulf and pathogenic microbe killing.
In Chinese medicine and western medicine complex provided by the present invention, drug matching is swollen based on heat-clearing and toxic substances removing, medicinal powder for relieving pain, activating blood circulation to dissipate blood stasis, and strengthening the spleen and stomach is auxiliary.In concrete treatment, the kinds of traditional Chinese medicines for the treatment of mammitis of cow has stimulation to animal body immune system, but active component contained by each medicine is different, its model of action is not identical yet, as taurine can improve nerve conduction function, activates pancreas simultaneously, thus improve the state of the hormonal system of body, improve the immune phagocytic function of cell, the generation of Promote immunity globulin, improve the immunity of body; And the Radix Angelicae Dahuricae in compositions is from Chinese medicine pharmacology, to dispel the wind, wet dissipation, evacuation of pus, granulation promoting analgesic efficacy, say then have antiinflammatory, antibacterial, antipyretic effect, can pain be alleviated from pathology, promote the recovery of animal body; The compositions such as the polysaccharide in Radix Angelicae Sinensis, alkaloid, flavonoid, glycoside, trace element also have the effect such as phagocytosis, inducing mammary endolymph Cells Interferon Production strengthening reticuloendothelial system.In general, in Chinese medicine and western medicine complex provided by the present invention, western medicine composition is in order to the quick control state of an illness, Chinese medicine ingredients is then put forth effort on from from enhancing body specificity, nonspecific immunity two aspect improves mammary gland tissue anti-infection ability, specifically, Chinese medicine is from enhancing cellular immunization, humoral immunization and improve Related Component at the orientation enhancement mammary gland Effects on local immunological functions such as working order of mammary gland local and improve immunity of organisms comprehensively, thus strengthen animal to the resistivity of mastitis, thus there is Chinese medicine and western medicine compatibility appropriate, harmonious, remarkably productive stable feature.
In general, the present invention be on clinical experience basis for many years screen and sum up a kind of Chinese medicine and western medicine compound formulation, Chinese medicine ingredients compatibility is wherein reasonable, there is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling eliminating stagnation, the effects such as detumescence stimulating milk secretion, with Western medicine formula compound, there is noresidue, nuisanceless, Environmental Safety, production technology is simple, the advantage such as easy to use, through practice test, the present invention is when for preventing and treating bovine subclinical mastitis, there is good anti-inflammation, noresidue, have no side effect, and the therapeutic effect of milch cow immunity of organisms can be improved, thus there is good practical value.
Detailed description of the invention
Below in conjunction with embodiment the present invention will be further explained explanation.
embodiment 1
The Chinese medicine and western medicine complex of the control bovine subclinical mastitis that the present embodiment provides, form by following Chinese medicine and western medicine raw material is composite, weight proportion ratio is; levamisole hydrochloride 10g, taurine 25g, Flos Lonicerae 55g; Radix Angelicae Sinensis 45g, Pericarpium Citri Reticulatae 25g, Radix Saposhnikoviae 15g; Radix Angelicae Dahuricae 15g, Bulbus Fritillariae Uninbracteatae 20g, Olibanum 20g; Myrrha 20g; Radix Paeoniae Rubra 25g, Squama Manis 15g, Radix Glycyrrhizae 10g.
During preparation, after first each Chinese crude drug being dried or dried, take in proportion, pulverized 60 ~ 80 mesh sieves, then add the mixing of Western medicine levamisole hydrochloride in proportion, subpackage completes.
embodiment 2
The Chinese medicine and western medicine complex of the control bovine subclinical mastitis that the present embodiment provides, form by following Chinese medicine and western medicine raw material is composite, weight proportion ratio is; levamisole hydrochloride 13g, taurine 28g, Flos Lonicerae 58g; Radix Angelicae Sinensis 48g, Pericarpium Citri Reticulatae 28g, Radix Saposhnikoviae 18g; Radix Angelicae Dahuricae 18g, Bulbus Fritillariae Uninbracteatae 28g, Olibanum 28g; Myrrha 28g; Radix Paeoniae Rubra 28g, Squama Manis 18g, Radix Glycyrrhizae 18g.
During preparation, after first each Chinese crude drug being dried or dried, take in proportion, pulverized 60 ~ 80 mesh sieves, then add the mixing of Western medicine levamisole hydrochloride in proportion, subpackage completes.
embodiment 3
The Chinese medicine and western medicine complex of the control bovine subclinical mastitis that the present embodiment provides, form by following Chinese medicine and western medicine raw material is composite, weight proportion ratio is; levamisole hydrochloride 15g, taurine 30g, Flos Lonicerae 60g; Radix Angelicae Sinensis 50g, Pericarpium Citri Reticulatae 30g, Radix Saposhnikoviae 20g; Radix Angelicae Dahuricae 20g, Bulbus Fritillariae Uninbracteatae 30g, Olibanum 30g; Myrrha 30g; Radix Paeoniae Rubra 30g, Squama Manis 20g, Radix Glycyrrhizae 20g.
During preparation, after first each Chinese crude drug being dried or dried, take in proportion, pulverized 60 ~ 80 mesh sieves, then add the mixing of Western medicine levamisole hydrochloride in proportion, subpackage completes.
For checking the concrete therapeutic effect of the Chinese medicine and western medicine complex of control bovine subclinical mastitis provided by the present invention, based on the Chinese medicine and western medicine complex of the control bovine subclinical mastitis prepared by embodiment 2, inventor has done again further test experience, briefly introduces as follows.
experimental example 1
Experimental period: autumn in 2013.
Setup Experiments: the healthy holstein cow 20 selecting 1 ~ 3 parity, selected milch cow somatic number level in every milliliter of Lac Bovis seu Bubali of secreting is between 20 ~ 500,000/ml, the principle close according to milk yield, lactation stage, body weight are close, be divided into test group and matched group at random, matched group 6, test group 14.Experimentation: each group basal diet is identical, difference is only the Chinese medicine and western medicine complex 200g that test group milch cow every every day to be added embodiment 2 and provides, and matched group does not add.Carry out the feeding experiment of 15 days, duration of test, cowshed daily mean temperature is 22. 5 DEG C, humidity-temperature index (THI) is 64. 16, records the milk yield of milch cow every day, and observes search for food situation and the mental status, the 15th day of off-test, gathers milk sample and carries out analysis of milk composition.
Experiment statistics result is as shown in the table.
Can draw from this experimental result and upper table:
(1) show somatic number mensuration in every milliliter of Lac Bovis seu Bubali, matched group 6 cow head is secreted somatic number in Lac Bovis seu Bubali and is greater than 500,000/ml, and soprano reaches 1,630,000/ml; And test group only has I cow head to secrete somatic number in Lac Bovis seu Bubali is greater than 500,000/ml, concrete numerical value is 78. 6 ten thousand/ml;
(2) lactation amount is measured compare and show, test group milk yield 15. 4% (P<0.s 05) higher than matched group, and the lactoprotein of test group is higher than the average level of matched group milch cow, but difference is not significantly (P>0. 05).
To sum up, above result shows that this product effectively can prevent the sickness rate of bovine subclinical mastitis, improves milk yield, improves milk-quality.
experimental example 2
Experimental period: spring in 2013.
Setup Experiments: select 1 ~ 3 parity holstein cow 30, selected milch cow somatic number level in every milliliter of Lac Bovis seu Bubali of secreting, at 500,000/more than ml, according to the level of giving milk, body weight phase approximately principle, is divided into matched group and test group at random, often organizes each 15.
Experimentation: in experimentation, each group basal diet is identical, and difference is only that matched group does not add any other material, test group milch cow every every day to add the Chinese medicine and western medicine complex 300g that embodiment 2 provides, and is mixed in concentrated feed.Carry out the feeding experiment of 15 days.Duration of test, cowshed daily mean temperature 12. 5 ° of C, humidity-temperature index (THI) is 56. 80.Record feed intake and the mental status of milk yield and two groups of milch cows every day, after off-test in 15 days, gather milk sample, and carry out analysis of milk composition.
Experiment statistics result is as shown in the table.
As can be seen from this experimental result and upper table:
(1) somatic number mensuration in every milliliter of Lac Bovis seu Bubali is shown, matched group milch cow secretes somatic number in every milliliter, Lac Bovis seu Bubali Lac Bovis seu Bubali and is significantly higher than test group milch cow (P < 0. 05), specifically, matched group 15 cow head to secrete in Lac Bovis seu Bubali somatic number all at 500,000/more than ml, and on the rise; And in test group, somatic number is at 500,000/below ml to have 13 cow heads to secrete in Lac Bovis seu Bubali, all the other 2 also decline to some extent.This also just shows that Chinese medicine and western medicine complex provided by the present invention is 100% to the effective percentage of bovine subclinical mastitis, and cure rate is 86.7%.
(2) measure lactation amount and compare and show, test group comparatively matched group milk yield improves 12.6% (P < 0. 05); And test group butterfat percnetage increases than matched group, but difference is not significantly (P>0. 05).
Above result shows that Chinese medicine and western medicine complex provided by the present invention can effectively play and reduces latent mammitis sickness rate, reduces Methods of Milk Somatic Cell Images number, improves the effect of milk yield, improve milk-quality; And nonreactive remains, has no side effect, and to milch cow without harm.
Claims (3)
1. prevent and treat a Chinese medicine and western medicine complex for bovine subclinical mastitis, it is characterized in that, this complex forms by following Chinese medicine and western medicine raw material is composite; weight proportion ratio is, levamisole hydrochloride 10 ~ 15g, taurine 25 ~ 30g; Flos Lonicerae 55 ~ 60g, Radix Angelicae Sinensis 45 ~ 50g, Pericarpium Citri Reticulatae 25 ~ 30g; Radix Saposhnikoviae 15 ~ 20g, the Radix Angelicae Dahuricae 15 ~ 20g, Bulbus Fritillariae Uninbracteatae 20 ~ 30g; Olibanum 20 ~ 30g, Myrrha 20 ~ 30g, Radix Paeoniae Rubra 25 ~ 30g; Squama Manis 15 ~ 20g, Radix Glycyrrhizae 10 ~ 20g.
2. prevent and treat the Chinese medicine and western medicine complex of bovine subclinical mastitis as claimed in claim 1, it is characterized in that, each proportioning raw materials is; levamisole hydrochloride 13g, taurine 28g, Flos Lonicerae 58g; Radix Angelicae Sinensis 48g, Pericarpium Citri Reticulatae 28g, Radix Saposhnikoviae 18g; Radix Angelicae Dahuricae 18g, Bulbus Fritillariae Uninbracteatae 28g, Olibanum 28g; Myrrha 28g; Radix Paeoniae Rubra 28g, Squama Manis 18g, Radix Glycyrrhizae 18g.
3. prevent and treat the Chinese medicine and western medicine complex of bovine subclinical mastitis described in claim 1, in prevention or the purposes for the treatment of bovine subclinical mastitis, it is characterized in that,
During for preventing bovine subclinical mastitis, use in the Lactation of Dairy Cow phase, by every every day 200g consumption make an addition in basal diet, use 15 days continuously;
When being used for the treatment of bovine subclinical mastitis, use in the Lactation of Dairy Cow phase, by every every day 300g consumption make an addition in basal diet, continuously use 15 days.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606296A (en) * | 2015-02-16 | 2015-05-13 | 内蒙古华天制药有限公司 | Ultra-micro mongolian medicine for preventing and treating decreased lactation and red swollen breasts of dairy cow and preparation method of ultra-micro mongolian medicine |
| CN104938822A (en) * | 2015-06-06 | 2015-09-30 | 安徽极速时代动物营养有限公司 | Feed additive for reducing cow body cells and treating recessive mastitis and preparation method of feed additive |
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| CN107648383A (en) * | 2017-11-01 | 2018-02-02 | 广西吉朋投资有限公司 | A kind of protective agents of mastitis for milk cows and preparation method thereof |
| CN115211500A (en) * | 2022-03-18 | 2022-10-21 | 辽源市禹然农业发展有限公司 | A feed containing herba Taraxaci for mammals and poultry, and its preparation method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606296A (en) * | 2015-02-16 | 2015-05-13 | 内蒙古华天制药有限公司 | Ultra-micro mongolian medicine for preventing and treating decreased lactation and red swollen breasts of dairy cow and preparation method of ultra-micro mongolian medicine |
| CN104606296B (en) * | 2015-02-16 | 2018-02-23 | 内蒙古华天制药有限公司 | It is a kind of to be used to preventing and treating Lactation of Dairy Cow is reduced, breast is red and swollen ultra micro anaesthetic and preparation method thereof |
| CN104938822A (en) * | 2015-06-06 | 2015-09-30 | 安徽极速时代动物营养有限公司 | Feed additive for reducing cow body cells and treating recessive mastitis and preparation method of feed additive |
| CN105410368A (en) * | 2015-11-22 | 2016-03-23 | 衡阳市富矿饲料添加剂有限公司 | Feed additive for preventing dairy cattle subclinical mastitis and preparation method thereof |
| CN107648383A (en) * | 2017-11-01 | 2018-02-02 | 广西吉朋投资有限公司 | A kind of protective agents of mastitis for milk cows and preparation method thereof |
| CN115211500A (en) * | 2022-03-18 | 2022-10-21 | 辽源市禹然农业发展有限公司 | A feed containing herba Taraxaci for mammals and poultry, and its preparation method |
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