CN103272085B - Traditional Chinese medicine composition for treating eperythrozoonosis of dairy cows and preparation method thereof - Google Patents

Abstract

A traditional Chinese medicine composition for treating eperythrozoonosis in dairy cows and a preparation method thereof, relating to a medicine for treating eperythrozoonosis in dairy cows; , licorice, and Artemisia annua; the above raw materials are mixed, soaked in water, and filtered for a certain period of time; this composition is safe and effective, has no drug resistance, and has the functions of killing insects and eliminating accumulation, clearing away heat and detoxification, stopping bleeding and cooling blood, and nourishing qi and blood. , Harmonize the stomach and invigorate the spleen, enhance the body's resistance and immunity.

Description

A traditional Chinese medicine composition for treating dairy cow eperythrozoonosis and its preparation method

technical field

The invention belongs to a traditional Chinese veterinary medicine composition, in particular to a composition for treating dairy cow eperythrozoonosis and a preparation method thereof.

Background technique

Eperythrozoonosis of dairy cows is a zoonotic disease characterized by anemia, hemolytic jaundice, fever, and dyspnea. my country is one of the countries with the most severe prevalence of Eperythrozoonosis in dairy cattle, and 20 provinces, municipalities and autonomous regions have reported the occurrence of the disease. With the rapid development of the dairy farming industry, the degree of intensification is getting higher and higher, and the disease has changed from a seasonal onset to a four-season onset, and the infection rate of Eperythrozoon in dairy cows is as high as 50%-90% in some areas. The disease can cause slow growth of dairy cows, decreased milk production and reproductive disorders, and is often accompanied by production diseases such as endometritis, mastitis and production paralysis, bringing huge economic losses to the dairy farming industry. At the same time, as a zoonotic disease, dairy cow eperythrozoonosis seriously threatens human health. In some areas, the human infection rate is as high as 40%, and it can even reach more than 70% among adolescents. It is manifested as chronic fatigue syndrome, and some patients also have Nervous dysfunction and sleep disturbance. Because most patients show sub-health status after infection, the disease is often neglected in human clinical practice.

At present, there are few specific drugs for the treatment of Eperythrozoonosis in dairy cows. Clinically, the antiparasitic western medicines imidazolium, triazamidine (Benier), oxytetracycline, doxycycline, penicillin, etc. are mainly used to kill parasites, antibacterial and anti-inflammation , but the effect is not ideal. Imidazuron is more effective in treating the disease, but the drug cannot enter the bone marrow, cannot completely kill Eperythrozoon, and is expensive, and it is easy to relapse after stopping the drug. Triazamidine has relatively large toxic and side effects, a small safety range, and easily produces drug residues.

Contents of the invention

The effect of using antibiotics to treat the disease is inaccurate, and the parasites are prone to develop drug resistance, and the pathogens cannot be completely eliminated, which may easily cause drug residues. The arsenic preparation trichlorfon liquid can treat bovine eperythrozoonosis, but it is easy to cause toxic arsenic residues in beef and milk.

Clinically, antimalarial and anthelmintic traditional Chinese medicine prescriptions are commonly used to treat this disease, such as the prescriptions developed by Guo Hongjun and others: Artemisia annua, Changshan, Ephedra, almond, gypsum, Tinglizi, Digupi, Morus alba, Anemarrhena, and Scutellaria baicalensis , licorice; another example is the prescription of Wan Guoshun and others: Artemisia annua, buffalo horn, scrophulariaceae, mast, platycodon, skullcap, anemarrhena, white peony root, forsythia, habitat, fresh bamboo leaves, paeonol, comfrey, drought Lotus grass, agrimony, ink bucket grass, licorice. This type of prescription includes Scrophulariaceae and gypsum, which have the function of purging, and can purify internal heat while expelling insects. It has a certain curative effect, but it cannot relieve the symptoms of anemia and jaundice. Sick cows with weak constitutions will have spleen deficiency and stool. Loose soup, aggravating the condition. Clinically, it is also seen that the combination of traditional Chinese and Western medicine is used to treat this disease. The common Chinese medicine prescriptions that are combined with western medicine include Shiquan Dabu Decoction, Dangshen Yangrong Decoction, etc. Shiquan Dabu Fang combined with western medicine can obviously alleviate the anemia, jaundice and allergic reaction caused by the infection of Eperythrozoon, but it cannot completely remove the parasite, and it is easy to repeat. Codonopsis Yangrong Decoction can alleviate the disease and increase the appetite of the affected animals, but it cannot eliminate the parasites, and it is easy to relapse, and it can treat the symptoms but not the root cause. Therefore, the research and development of a safe and efficient traditional Chinese medicine composition for the treatment of dairy cow eperythrozoonosis is of great significance to the healthy development of the dairy farming industry.

Contents of the invention

The purpose of the present invention is to aim at the problems existing in the treatment of dairy cow eperythrozoonosis, to research and develop a traditional Chinese medicine composition for treating dairy cow eperythrozoonosis and a preparation method thereof, so as to improve the cure rate of dairy cow eperythrozoonosis, prevent recurrence, and The purpose of low cost and no side effects.

The purpose of the present invention is achieved in this way: the composition is prepared from the following raw materials and dosage: Changshan 45-60g, Betel nut 45-60g, Radix Radix 45-60g, Forsythia 30-50g, Scrophulariaceae 20-40g, Codonopsis 40-60g , Angelica 40-60g, Atractylodes macrocephala 40-60g, licorice 30-50g, Artemisia annua 20-45g. Add 2000-2500ml of normal temperature water to all the Changshan, betel nut, isatis root, forsythia, scrophulariaceae, codonopsis, angelica, atractylodes macrocephala, and licorice in the dosage, soak for 60 minutes, simmer for 30-45 minutes, filter to remove the residue to obtain the liquid medicine About 50mL; then add 1500-2000mL water to the filtered medicinal residue, decoct with slow fire for 30-45 minutes, filter to obtain about 50mL of medicinal liquid, combine the medicinal liquid obtained by two filtrations, and reduce the combined medicinal liquid to 50-60 After 20° C., soak 20-45 g of crushed Artemisia annua for 2 hours with heat preservation, filter out the medicinal residues, and finally obtain a dose of traditional Chinese medicine composition for treating eperythrozoonosis in dairy cows.

The traditional Chinese medicine composition is widely drawn, low in cost, safe and effective, free of drug resistance, easy to use, and not repeated. The effect of immunity. In several years, the composition was used to treat 153 dairy cows suffering from Eperythrozoonosis, 140 of which were cured and 3 died, with a cure rate of more than 90%, and the cure did not recur, and the curative effect was remarkable. The traditional Chinese medicine composition is of great significance for treating the eperythrozoonosis of dairy cows and promoting the healthy development of the dairy cattle breeding industry.

Detailed ways

The present invention is described in detail with examples below.

Take Changshan 50g, Betel nut 50g, Banlangen 45g, Forsythia 30g, Scrophulariae 30g, Codonopsis 45g, Angelica 45g, Atractylodes macrocephala 45g, Licorice 35g, Artemisia annua 30g.

The preparation process is as follows: add 2000 mL of normal temperature water to all the ingredients in the dosage, such as Changshan, betel nut, isatis root, forsythia, scrophulariae, codonopsis, angelica, atractylodes macrocephala, and licorice, soak for 60 minutes, decoct with slow fire for 40 minutes, filter to remove the residue to obtain the liquid medicine About 50mL; then add 2000mL of water to the filtered medicinal residue, decoct with slow fire for 40 minutes, filter to obtain about 50mL of medicinal liquid, combine the two medicinal liquids, lower the combined medicinal liquid to 50-60°C, and soak 45g in heat preservation Smash Artemisia annua for 2 hours, filter to remove medicinal residues, and obtain a dose of traditional Chinese medicine composition for treating eperythrozoonosis in cows.

The method of use is as follows: the above-mentioned traditional Chinese medicine composition for treating eperythrozoonosis in dairy cows is fed to sick cows, once in the morning and once in the evening, one dose per day, and 4-7 doses in succession depending on the condition.

Treatment of disease column 1

On August 6, 2012, a 4-year-old cow from a cattle farm in Shangzhi City, Heilongjiang Province fell ill. The main complaint was that the cow had a fever a week ago and was diagnosed with Eperythrozoonosis at the township veterinary station. It was treated with western medicine imidazolium His body temperature dropped to normal, but he ate less, ruminated less, lacked energy, and night sweats. He had been treated with cephalosporin, concentrated glucose, amino acids, and sodium dicarbamate, but the effect was not obvious. On diagnosis, the suffering animal was tired and weak, unwilling to walk, with light yellow conjunctiva, loose stools, yellow urine, palpitations and fright, and was diagnosed as Eperythrozoon positive by the animal epidemic monitoring center of this city. Treat with above-mentioned Chinese medicine composition, every day 1 dose, serve on 6 doses continuously, the symptom alleviates after the 3rd day of main state medication, fully recovers on the 6th day. Half a year later, a return visit by telephone did not occur again.

Treatment of disease column 2

On May 28, 2012, a dairy cow raised by Su in Liuhe Town, Mulan County, Heilongjiang Province, weighing 600 kg and producing 30 kg of fresh milk a day, suddenly lost appetite 90 days after giving birth, sluggish, depressed, decreased milk production, coughed, diarrhea. Clinical examination: the affected cow was thin, visible mucous membranes and udders were yellow stained, rumen peristalsis weakened, through emergency consultation and laboratory examination, it was confirmed that Eperythrozoon was positive, and the affected cow improved slightly after being treated with Bernier, but the treatment was stopped After half a month, the condition recurred again. The sick cow was immediately treated with the above-mentioned traditional Chinese medicine composition, 1 dose a day, and 5 doses in a row. The main statement was that the symptoms were relieved after the second day of the medication, and the appetite of the cow gradually recovered. The disease was recovered on the 5th day, and the follow-up visit after half a month showed that the appetite of the cow was normal. , milk production increased, ear apex blood smear microscopic examination with erythrocytes turned negative.

Treatment of disease column 3

In mid-July 2012, 9 of the 23 adult cows in a dairy farm in Baicheng City, Jilin Province had a loss of appetite, decreased rumination, increased body temperature to 40-41.5°C, rapid breathing, and decreased milk production; a few cows had hematuria, Constipation and diarrhea appeared alternately. Three sick cows had bloody feces, and one pregnant cow had a miscarriage; two calves had jaundice. According to clinical symptoms and blood smear microscopic examination results, the patient was diagnosed as Eperythrozoonosis, and treated with Benier combined with oxytetracycline, but no effect was achieved. Immediately treated with the above-mentioned Chinese medicine composition, 1 dose per day, 7 doses in a row, the symptoms of most sick cattle were obviously relieved on the 3rd day after the medication, and returned to normal after the 7th day. One very ill adult cow was extremely emaciated and died on the second day of treatment. Post-mortem examination revealed that the carcass of the dead cow was extremely emaciated, with reduced skin elasticity and obvious rigor; the visible mucous membrane was pale and yellow; the lymph nodes were enlarged throughout the body, the cortex was purplish red or taupe, and the cut surface was everted and juicy; the blood coagulation was poor , bright red; myocardium dilated, pale and soft, epicardium, coronary fat yellow stained and scattered old bleeding spots of different sizes; liver enlargement, brownish yellow; gallbladder enlargement, thick bile; kidney edema, with A small amount of bleeding points; autopsy showed no obvious lesions in other tissues. A total of 9 sick cows were treated for the farm, 8 were cured and 1 died.

Treatment of disease column 4

In November 2012, the author treated a dairy cow suffering from Eperythrozoonosis. The body temperature of the sick cow is 39.8°C, the coat is rough and disorderly, the spirit is depressed, the appetite and rumination are reduced or completely lost; the visible mucous membrane is yellow, accompanied by mastitis; constipation, the feces are dry and hard covered with mucus. After being treated with the traditional Chinese medicine composition, the sick cows improved significantly after 3 days, and returned to normal after 7 days. One week after stopping the drug, the blood smears were tested by acridine orange staining microscope and enzyme-linked immunosorbent assay, and the results turned negative. the

Claims (1)

1. treat a Chinese medicine composition for eperythrozoonosis in dairy cow, it is characterized in that said composition is prepared by following raw material, dose and method: Radix Dichroae 45-60g, Semen Arecae 45-60g, Radix Isatidis 45-60g, Fructus Forsythiae 30-50g, Radix Scrophulariae 20-40g, Radix Codonopsis 40-60g, Radix Angelicae Sinensis 40-60g, Rhizoma Atractylodis Macrocephalae 40-60g, Radix Glycyrrhizae 30-50g; In the raw material of above-mentioned all categories and quality, add normal-temperature water 2000-2500mL, soak 45 minutes, 30-45 minute at a simmer, filter and remove residue obtains medicinal liquid and is about 50mL; 1500-2000mL water is added again in the medicinal residues after filtration, 30-45 minute at a simmer, filter medicinal liquid is about 50mL, merge the medicinal liquid of twice, after the medicinal liquid of merging is cooled to 50-60 DEG C, the Herba Artemisiae Annuae 25-45g that heat-insulation soaking batters down 2 hours, filter and remove residue, finally obtains the Chinese medicine composition of potion treatment eperythrozoonosis in dairy cow.