CN103142776B - Traditional Chinese medicine composition for treating endometritis of sheep and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating endometritis of sheep and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating endometritis of sheep. The traditional Chinese medicine composition comprises the following components by weight: 20-30 parts of climbing groundsel herb, 30-40 parts of radix sophorae flavescentis, 30-40 parts of scutellaria baicalensis, 30-40 parts of coptis root, 30-40 parts of bighead atractylodes rhizome, 30-40 parts of dandelion, 30-40 parts of herba epimedii, 50-70 parts of motherwort herb, 50-70 parts of codonopsis pilosula, 50-70 parts of herba aristolochiae, 50-70 parts of angelica sinensis, 30-40 parts of cowherb seed, 20-30 parts of pollen typhae, 20-30 parts of astragalus mongholicus and 20-30 parts of liquorice. The invention also discloses a preparation method of the traditional Chinese medicine composition for treating endometritis of sheep. By effectively combining the functions of four core medicines including angelica sinensis, motherwort herb, codonopsis pilosula and herba aristolochiae and eleven auxiliary medicines such as climbing groundsel herb, and by using the preparation method, the contraction of uterine smooth muscles is strengthened, the heat clearing, bacteriostatic and anti-inflammatory effects are achieved, the immunity of the organism is improved, and the pesticide effect of stopping bleeding and easing pain is realized, so that the cure rate of endometritis of sheep is effectively improved, the reproductive capacity of the sheep is enhanced, and financial loss of farmers is reduced. The traditional Chinese medicine composition has great significance for promoting the healthy development of sheep industry.
Description
Technical field
The invention belongs to animal medicinal composition, be specifically related to a kind of Chinese medicine composition and preparation method thereof, relate in particular to one and treat sheep endometritis composition and method of making the same.
Background technology
Endometritis is the inflammation of Uterine mucosa, often because childbirth, practise midwifery, the prolapsus uteri, vagina are deviate from, the secondary antibacterial such as placenta retention and peritonitis infects and causes.A kind of commonly encountered diseases in the endometritis Shi Yang obstetrics disease of sheep, betides ewe birth process or puerperal mostly, and sheep and goat all can be fallen ill, and can occur in the links in reproductive process.
Endometritis can be divided into acute endometritis and chronic endometritis, and chronic endometritis is divided into again chronic mucus endometritis and chronic purulent endometritis according to the character of secretions.Wherein, acute intimitis generally betides birth process, post-abortion or is secondary to placenta retention, and sick sheep symptom is obvious, shows as fervescence more, lethargy, and appetite depression, ruminates and reduces or give up absolutely; Common hogback, exert duty, the posture of often urinating, flows out the dirty red secretions of smelling as of rotten fish from vaginal orifice, can secondary colpitis.If treatment or treatment improper measures not in time, can be transformed into chronic endometritis, now suffer from sheep General Symptoms not obvious, appetite is slightly poor, vaginal orifice is discharged a small amount of Catarrhal or muddy secretions, contaminated environment not only when rheuminess thing is discharged from vagina, and can cause suffering from sheep irregular even the stopping that oestrusing and oestrus, Repeat breeding.The inflammation damnification of acute and chronic endometritis all may feed through to myometrium, forms metritis, or secondary pyometra causes permanent infertilely, causes serious economic loss to sheep husbandry.
At present, the economic loss of bringing in order to reduce sheep endometritis, except taking various preventive measures, common treatment means comprises following several.(1) rinse and purify uterus, conventional washing liquid is by 0.1%～0.2% ethacridine solution, 0.1% compound iodine solution, 0.1%～0.3% potassium permanganate solution, the mixed liquor of 1% alum solution of 0.1%～0.2% sodium bicarbonate solution and equivalent; Washing liquid is poured in cavity of uterus, then discharge and pour into intrauterine disinfectant solution with siphonage, every day 1 time, till can even doing the liquid-transparent of extremely discharging for 3～4 times; (2) rinse uterus and be combined with subcutaneous injection, to promote uterine contraction, reduce or stop exudate to absorb; Adopt 5%～10% sodium chloride solution 200～300ml every day or rinse every other day uterus 1 time, and along with exudate reduces and the raising of strength of uterine contraction, gradually washing liquid concentration is reduced to 1%, and reduce consumption; Subcutaneous or intramuscular injection diethylstilbestrol, pituitrin or oxytocin etc. simultaneously; (3) rinse with intrauterine perfusion antibiotic and be combined, after flushing drain, select penicillin, each 500,000～1,000,000 IU of streptomycin, or oxytetracycline 0.5g is dissolved in 100ml cod-liver oil, then add pituitrin 5IU, inject intrauterine, every day 1 time, after 4～6 days 1 time every other day; (4) treatment by Chinese herbs, uses Fructus Forsythiae 10g, Radix Paeoniae Rubra 4g, and Radix Scutellariae 5g, Cortex Moutan 4g, Semen Persicae 4g, Rhizoma Cyperi 5g, Rhizoma Corydalis 5g, Semen Coicis 5g, Herba Taraxaci 5g, decocting is waited temperature, once gavages; Chronic case, uses Herba Leonuri 5g, Radix Angelicae Sinensis 8g, and Pollen Typhae 5g, Rhizoma Chuanxiong 3g, Poria 5g, Semen Persicae 3g, Oletum Trogopterori 4g, Rhizoma Cyperi 4g, decocting is waited temperature and is added yellow wine 20ml, once gavages, and 1 times/day, 2～3d is a course for the treatment of.
The method of above-mentioned treatment sheep endometritis is all to use the Therapeutic Method of cow endometritis, the method treatments that adopt intrauterine to inject antibiotic and antiseptic and disinfectant drug more, there is shortcomings in these methods: (1) pathogen produces drug resistance to antibiotic, reduces therapeutic effect; (2) antiseptic damages endometrium, and can upset to a certain extent the egodefense function in uterus; (3) inevitable drug residue can affect the fertility of sheep to a certain extent; (4) although intrauterine perfusion antibiotic can be removed some antibacterial, cannot eliminate endometrial inflammation or recover reproductive capacity, and need heavy dose of minimal inhibitory concentration (5 μ g/g) that just can reach endometrium local organization, and therapeutic effect is limited.
Summary of the invention
For the problems referred to above that exist in the treatment for the treatment of sheep endometritis, the present invention has developed one and has treated sheep endometritis Chinese medicine composition, described Chinese medicine composition has not only increased substantially the cure rate of sheep endometritis, and with low cost, have no side effect; The invention also discloses the preparation method of described Chinese medicine composition.
Technical scheme of the present invention is: a kind of Chinese medicine composition for the treatment of sheep endometritis, and meter, comprises following various component: 20-30 part Herba Senecionis Scandentis by weight, 30-40 part Radix Sophorae Flavescentis, 30-40 part Radix Scutellariae, 30-40 part Rhizoma Coptidis, 30-40 part Rhizoma Atractylodis Macrocephalae, 30-40 part Herba Taraxaci, 30-40 part Herba Epimedii, 50-70 part Herba Leonuri, 50-70 part Radix Codonopsis, 50-70 part Herba Aristolochiae, 50-70 part Radix Angelicae Sinensis, 30-40 part Semen Vaccariae, 20-30 part Pollen Typhae, 20-30 part Radix Astragali, 20-30 part Radix Glycyrrhizae.
A preparation method for the treatment of the Chinese medicine composition of sheep endometritis, comprises the following steps:
1. prepare medicament: take 20-30 part Herba Senecionis Scandentis, 30-40 part Radix Sophorae Flavescentis, 30-40 part Radix Scutellariae, 30-40 part Rhizoma Coptidis, 30-40 part Rhizoma Atractylodis Macrocephalae, 30-40 part Herba Taraxaci, 30-40 part Herba Epimedii, 50-70 part Herba Leonuri, 50-70 part Radix Codonopsis, 50-70 part Herba Aristolochiae, 50-70 part Radix Angelicae Sinensis, 30-40 part Semen Vaccariae, 20-30 part Pollen Typhae, 20-30 part Radix Astragali, 20-30 part Radix Glycyrrhizae;
2. boil medicament: in the medicament 1. preparing to step, add 2500-3000 part normal-temperature water, soak 30 minutes; After intense fire boils, adopt slow fire to continue to decoct 40-50 minute, filter, obtain medicinal residues and a medicinal liquid; In described medicinal residues, add again 2000-2500 part normal-temperature water, adopt 40-45 minute at a simmer, filter, obtain secondary medicinal liquid; Medicinal liquid and secondary medicinal liquid are merged, obtain the Chinese medicine composition of potion treatment sheep endometritis.
Core drug in the Chinese medicine composition for the treatment of sheep endometritis of the present invention comprises Radix Angelicae Sinensis, Herba Leonuri, Radix Codonopsis and Herba Aristolochiae: (1) Radix Angelicae Sinensis can be strengthened the contraction of uterine smooth muscle, promote the discharge of endometrium foreign body, also have bacteriostasis, can effectively alleviate infection; (2) Herba Leonuri possesses the effect of shrinking uterus, plays synergism with Radix Angelicae Sinensis; (3) Radix Codonopsis energy enhancing human body immunity power, has also further strengthened the hemopoietic function of Radix Angelicae Sinensis; (4) Herba Aristolochiae is used for anti-bacteria, and collaborative Radix Angelicae Sinensis alleviates the infection of pathogenic site.Remove above-mentioned core drug, Herba Senecionis Scandentis, Radix Sophorae Flavescentis, Radix Scutellariae, Rhizoma Coptidis, Herba Taraxaci and the Rhizoma Atractylodis Macrocephalae all have very strong antipyretic antibacterial anti-inflammatory effect, the infection of auxiliary Radix Angelicae Sinensis, Herba Aristolochiae opposing pathogenic bacteria; Herba Epimedii, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae auxiliary Radix Angelicae Sinensis, Radix Codonopsis improve the immunity of ewe; The auxiliary Radix Angelicae Sinensis of Pollen Typhae, Semen Vaccariae, Herba Leonuri are strengthened uterine contraction, and Pollen Typhae promotes blood coagulation simultaneously, the Semen Vaccariae function of easing pain in addition.Radix Glycyrrhizae except can antiinflammatory, enhancing human body immunity power, also have the flavored action to Chinese medicine composition.
The pharmacological action of various Chinese medicines in the Chinese medicine composition for the treatment of sheep endometritis of the present invention:
(1) Herba Senecionis Scandentis: there is heat clearing away, removing toxic substances, parasite killing, improving eyesight and treat various acutely inflamed effects.Herba Senecionis Scandentis has broad ectrum antibiotic effect, and staphylococcus aureus, Bacillus typhi, paratyphoid bacillus A, Bacillus paratyphosus B, will he, Boydii, bacterium sonnei are all had to stronger inhibitory action; The decoct of Herba Senecionis Scandentis, ether extracting solution have In Vitro Anti spirillum effect in various degree; The decoct of Herba Senecionis Scandentis also has certain inhibitory action to trichomonas vaginitis.
(2) Radix Sophorae Flavescentis: the effect with heat clearing and damp drying, parasite killing, diuresis.Radix Sophorae Flavescentis is mainly used in treating hematodiarrhoea, has blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus and external treatment trichomonal vaginitis; Matrine has obvious diuresis, and the ether extract of Radix Sophorae Flavescentis and ethanol extract have stronger bacteriostasis to staphylococcus aureus.
(3) Radix Scutellariae: the effect with heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive and blood pressure lowering.Radix Scutellariae is mainly used in treating hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood and tells nosebleed, carbuncle sore tumefacting virus and frequent fetal movement.Baicalin, baicalin can effectively suppress acute inflammatory reaction, and baicalin can improve the quantity of macrophage, NK cell in body, thereby improve the immunologic function of body.
(4) Rhizoma Coptidis: the effect with heat clearing and damp drying, eliminating fire and detoxication.Rhizoma Coptidis is inhibited to dysentery bacterium, Bacillus typhi, escherichia coli, bacillus pyocyaneus, staphylococcus, Hemolytic streptococcus, Diplococcus pneumoniae, influenza virus, leptospira, ameba and dermatophytes.Rhizoma Coptidis can strengthen leukocytic phagocytic activity, thereby produces function of gallbladder promoting, expansion peripheral vessel, blood pressure lowering and gentle refrigeration function.
(5) Rhizoma Atractylodis Macrocephalae: the effect with invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive and diuresis.The Rhizoma Atractylodis Macrocephalae can strengthen the phagocytic function of reticuloendothelial system, improves lymphocytic conversion ratio, promotes the immunologic function of cell.The decoct of the Rhizoma Atractylodis Macrocephalae all has bacteriostasis in various degree to meningococcus, Bacillus typhi, paratyphoid bacillus A, shigella flexneri, escherichia coli, bacillus pyocyaneus, acrothesium floccosum, star nocardia etc.
(6) Herba Taraxaci: the effect with heat-clearing and toxic substances removing and dispersing swelling and dissipating binds.Herba Taraxaci has stronger bactericidal action to staphylococcus aureus resistance bacterial strain, Hemolytic streptococcus, and Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, Bacillus proteus, dysentery bacterium, Bacillus typhi etc. and micrococcus catarrhalis are also had to certain bactericidal action.The decoct of Herba Taraxaci can significantly improve human peripheral lymphocyte blast transformation rate in vitro, improves immunologic function.
(7) Herba Epimedii: there is effect of antibacterial, kidney-replenishing, bone and muscle strengthening and wind-damp dispelling significantly.The active component of Herba Epimedii is icariin and epimedium brevicornum polysaccharide, and Staphylococcus albus, staphylococcus aureus are had to remarkable inhibitory action.3,5,7-trihydroxy-2-(4-methoxy-phenyl)-8-(3-methyl-but-2-enyl)-chromen-4-one has excitatory neuron and promotes gonepoietic effect.
(8) Herba Leonuri: be mainly used in treating vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rush down blood and carbuncle skin infection.Leonurine is to escherichia coli, dysentery bacterium, achorion schoenleinii, and Pilus Caprae seu Ovis sample sporidiole bacteria, epidermophyton rubrum, starlike nocadia all have inhibitory action.Herba Leonuri decoct, ethanol extractum and contained leonurine etc. are all excitation to the uterus of the many animals such as rabbit, cat, dog, Cavia porcellus.
(9) Radix Codonopsis: the effect that possesses invigorating the spleen and replenishing QI and spleen invigorating lung benefiting.Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, Saponin and Alkaloid, has enhancing immunity, blood vessel dilating, blood pressure lowering, improves microcirculation, strengthens the effects such as hemopoietic function.
(10) Herba Aristolochiae: the effect with circulation of qi promoting removing dampness, promoting blood circulation and stopping pain.Herba Aristolochiae can be used for stomachache, colicky, edema during pregnancy, puerperal vim and vigour stomachache and the treatment of rheumatalgia.Herba Aristolochiae has certain inhibitory action to staphylococcus aureus and common dermatophytes.
(11) Radix Angelicae Sinensis: possess enrich blood, invigorate blood circulation, menstruction regulating and pain relieving and the effect of moisturizing laxation.Radix Angelicae Sinensis has " amphicheirality " to the effect in uterus, and the excited uterine smooth muscle of its water solublity non-volatile matter mass-energy makes to shrink and strengthens, and its volatile ingredient has inhibition uterus, reduces its rhythmicity and shrinks, and make atony of uterus, but the two is take excited composition as main.Radix Angelicae Sinensis all has certain inhibitory action to dysentery bacterium, Bacillus typhi, escherichia coli, Hemolytic streptococcus.
(12) Semen Vaccariae: possess promoting the circulation of blood regulating menstruation, reducing swelling and alleviating pain, the lactogenesis of invigorating blood circulation, expedite the emergence of effect of stimulating milk secretion and thymus dredging in puerperal.Its decoct has contraction to isolated uterine, and the effect of its ethanol immersion is stronger, and aqueous extract makes that tablet is for oral administration has positive effect to lactogenic and the involution of uterus.
(13) Pollen Typhae: the effect that possesses cooling blood for hemostasis and blood circulation promoting and blood stasis dispelling.Pollen Typhae promotes the contraction in uterus, shortens clotting time.Staphylococcus aureus, bacterium flexneri, bacillus pyocyaneus, escherichia coli, Bacillus typhi, the close Shigella flexneri of history and 2 type Salmonella paratyphi are all had to stronger inhibitory action.
(14) Radix Astragali: the effect that possesses invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus and expelling pus and promoting granulation.The Radix Astragali can be strengthened normal heart and shrink, and the heart of exhaustion is had to cardiotonic; Can expand coronary vasodilator and whole body peripheral vessel, make blood pressure drops; The secretory pit of the inaccessible skin of energy, suppresses diaphoresis, therefore there is anti-hidropoiesis.
(15) Radix Glycyrrhizae: the effect that possesses invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough and relieving spasm to stop pain.Poisoning and the diphtheria toxin, diphtherotoxin of glycyrrhizin in Radix Glycyrrhizae to food, interior metabolism product, tetanus toxin, snake venom etc. have stronger Detoxication; Glycyrrhizin and enoxolone and its esters have obvious antidiuretic activity; Radix Glycyrrhizae also has antiinflammatory, antianaphylaxis reagentia, and dysentery bacterium, anthrax bacillus, Hemolytic streptococcus, Diplococcus pneumoniae, staphylococcus aureus etc. are had to inhibitory action.
Beneficial effect of the present invention:
(1) Chinese medicine composition of the present invention effectively combines Radix Angelicae Sinensis, Herba Leonuri, Radix Codonopsis and Herba Aristolochiae four taste core medical materials and Herba Senecionis Scandentis etc. ten effect of auxiliary medical material simply, and the preparation method of employing coupling, realize reinforcement uterine myometrium, antipyretic antibacterial anti-inflammatory, improve immunity of organisms and take into account the drug effect of hemostatic analgesia, effectively improve the cure rate of sheep endometritis, improve the fertility of sheep, reduce raiser's economic loss, had great importance to promoting sheep husbandry to develop in a healthy way;
(2) Chinese medicine composition of the present invention is drawn materials extensive, with low cost, easy to use and safe and effective, not only there is anti-inflammation, heat-clearing and toxic substances removing, promoting blood circulation and stopping pain and the clear corruption turbid effect of dispelling, and immunity that can enhancing body, not only can reduce and cure the probability that sheep falls ill again, also can improve the resistance against diseases of healthy flock of sheep;
(3) Chinese medicine composition of the present invention has not only improved the cure rate of sheep endometritis greatly, but also improved cure after the fertility of sheep, efficiently solve the problem that prior art drug residue impacts sheep fertility;
(4) Chinese medicine composition of the present invention has been avoided antibiotic use, has therefore also just avoided the drug resistance problem that causes due to antibiotic use, also can not upset the egodefense function in uterus; Adopt this pharmaceutical treatment the case of 82 sheep and goat endometritis show, cure 67, dead and eliminate 15, cure rate reaches 81.7%, and sheep reproductive capacity after curing increases.
The specific embodiment
Below in conjunction with embodiment, the present invention is described further.
Embodiment 1:
1. prepare medicament: take 20g Herba Senecionis Scandentis, 30g Radix Sophorae Flavescentis, 30g Radix Scutellariae, 30g Rhizoma Coptidis, the 30g Rhizoma Atractylodis Macrocephalae, 40g Herba Taraxaci, 30g Herba Epimedii, 50g Herba Leonuri, 50g Radix Codonopsis, 50g Herba Aristolochiae, 50g Radix Angelicae Sinensis, 30g Semen Vaccariae, 20g Pollen Typhae, the 20g Radix Astragali, 20g Radix Glycyrrhizae.
2. boil medicament: in the medicament 1. preparing to step, add 2500ml normal-temperature water, soak 30 minutes; After intense fire boils, adopt slow fire to continue to decoct 50 minutes, filter, obtain medicinal residues and an about 100ml of medicinal liquid; In described medicinal residues, add again 2000ml normal-temperature water, adopt 40 minutes at a simmer, filter, obtain the about 100ml of secondary medicinal liquid; Medicinal liquid and secondary medicinal liquid are merged, obtain the Chinese medicine composition of potion treatment sheep endometritis.
The compositions of the above-mentioned treatment sheep endometritis being mixed with is down to 25～30 ℃ and gavages to sheep, sooner or later respectively once, 1 dose of every day, be used in conjunction 5～7 doses, in formula range, take the circumstances into consideration to add and subtract each component dosage according to the state of an illness and the large I of body weight.
Treatment case 1:2000 April, the author buys the cold sheep of 30 little tails of gestation for monitoring involution of uterus test, treats that sheep divides the puerperium, has 5 sheep to suffer from endometritis.When beginning, suffer from sheep lochia efflux time and extend, along with the development of the state of an illness, occur lassitude, fervescence, loss of appetite, the back of a bow, exerts duty, flows out mucus or mucopurulent secretion thing from vaginal orifice, and while keeping down, output, is more.Suffer from the equal significant prolongation of involution of uterus time of sheep for 5.Collection intrauterine sample is bacteriology and cultivates discovery, has escherichia coli, bacillus cereus, streptococcus, staphylococcus, corynebacterium, klebsiella, micrococcus luteus and bacillus pyocyaneus.When beginning, use sodium ampicillin (3mg/kg, 1 times/day) treatment, after use enrofloxacin (3mg/kg, 2 times/day) instead, be showed no effect.Use above-mentioned traditional Chinese medicine composition for treating instead, 1 dose of every day, serve on 7 doses, medication, after 2 days, is suffered from sheep mental status and is taken a turn for the better, and feed intake increases; Within after medication 4 days, no longer discharge mucopurulent secretion thing; After medication, gather uterus sample the 8th day time and do antibacterial culturing, result is all negative, cure rate 100%.After rutting, all gestation of 5 sheep.
Treat case 2:2001 April, when above-mentioned test is given a birth with sheep, have again 4 sheep to suffer from endometritis, wherein have 1 to be secondary to difficult labour, 1 is secondary to placenta retention.Clinical symptoms shows as: lochia efflux time extends, fervescence, and loss of appetite, the time is slightly long just from vaginal orifice outflow brown secretions frowzy.This time directly use above-mentioned Chinese medicine composition to treat, 1 dose of every day, a point morning and evening gavages for 2 times, is used in conjunction 7 doses.With after 2 doses of medicines, there are 3 sheep temperature declines, amount of drinking water and food-intake increase; With fully recovering after 7 doses of medicines, cure rate 75%.There is 1 sheep to die from pyaemia septica.
Embodiment 2:
1. prepare medicament: take 25g Herba Senecionis Scandentis, 35g Radix Sophorae Flavescentis, 35g Radix Scutellariae, 35g Rhizoma Coptidis, the 35g Rhizoma Atractylodis Macrocephalae, 30g Herba Taraxaci, 40g Herba Epimedii, 65g Herba Leonuri, 60g Radix Codonopsis, 65g Herba Aristolochiae, 60g Radix Angelicae Sinensis, 35g Semen Vaccariae, 25g Pollen Typhae, the 25g Radix Astragali, 30g Radix Glycyrrhizae.
2. boil medicament: in the medicament 1. preparing to step, add 2800ml normal-temperature water, soak 30 minutes; After intense fire boils, adopt slow fire to continue to decoct 40 minutes, filter, obtain medicinal residues and an about 100ml of medicinal liquid; In described medicinal residues, add again 2200ml normal-temperature water, adopt 45 minutes at a simmer, filter, obtain the about 100ml of secondary medicinal liquid; Medicinal liquid and secondary medicinal liquid are merged, obtain the Chinese medicine composition of potion treatment sheep endometritis.
The compositions of the above-mentioned treatment sheep endometritis being mixed with is down to 25～30 ℃ and gavages to sheep, sooner or later respectively once, 1 dose of every day, be used in conjunction 5～7 doses, in formula range, take the circumstances into consideration to add and subtract each component dosage according to the state of an illness and the large I of body weight.
Between treatment case 3:2007 year May in May to 2009, the author treats for the sick sheep that endometritis is suffered from by 2 of County of Shandong Provinces different little Wei Han sheep plant.2 plants have respectively endometritis to suffer from 26 and 31 of sheep, and ill sheep all occurs in puerperal, wherein have respectively 3 and 6 sheep to have difficult labour in the time giving a birth, and separately have 3 and 4 sheep generation placenta retention.Clinical manifestation is: poor appetite, and lassitude, fervescence, grinds one's teeth in sleep, and exerts duty, often does the posture of urinating, and flows out dirty red secretions from vaginal orifice, oestruses irregular or stops oestrusing, Repeat breeding.
In two sheep fields of table 1., endometritis is suffered from morbidity and the treatment situation (unit: only) of sheep
| Yang Chang | Suffer from sheep number | Difficult labour | Placenta retention | Average lambing | Cure | Dead washing in a pan | Cure rate (%) |
| Sheep field 1 | 26 | 3 | 3 | 2.31 | 22 | 4 | 84.6 |
| Sheep field 2 | 31 | 6 | 4 | 2.19 | 25 | 6 | 80.6 |
Embodiment 3:
1. prepare medicament: take 30g Herba Senecionis Scandentis, 40g Radix Sophorae Flavescentis, 40g Radix Scutellariae, 40g Rhizoma Coptidis, the 40g Rhizoma Atractylodis Macrocephalae, 35g Herba Taraxaci, 35g Herba Epimedii, 70g Herba Leonuri, 70g Radix Codonopsis, 70g Herba Aristolochiae, 70g Radix Angelicae Sinensis, 40g Semen Vaccariae, 30g Pollen Typhae, the 30g Radix Astragali, 25g Radix Glycyrrhizae.
2. boil medicament: in the medicament 1. preparing to step, add 3000ml normal-temperature water, soak 30 minutes; After intense fire boils, adopt slow fire to continue to decoct 45 minutes, filter, obtain medicinal residues and an about 100ml of medicinal liquid; In described medicinal residues, add again 2500ml normal-temperature water, adopt 45 minutes at a simmer, filter, obtain the about 100ml of secondary medicinal liquid; Medicinal liquid and secondary medicinal liquid are merged, obtain the Chinese medicine composition of potion treatment sheep endometritis.
The compositions of the above-mentioned treatment sheep endometritis being mixed with is down to 25～30 ℃ and gavages to sheep, sooner or later respectively once, 1 dose of every day, be used in conjunction 5～7 doses, in formula range, take the circumstances into consideration to add and subtract each component dosage according to the state of an illness and the large I of body weight.
Treat case 4:2003 July 26,2 years old goat of Laiyang City citizen Qi raising is ill.Lambing of this sheep of main suit 5 days, gives birth to 1 lamb, and appetite is bad ever since, and spirit is depressed, and the back of a bow, often does the posture of urinating, and climbs sleepingly, is reluctant to walk about, and cannot see and ruminates.The author checks discovery, and slightly disorderly, spirit is depressed for this Corii Caprae seu Ovis hair, and 39.5 ℃ of body temperature, 82 beats/min, pulse, breathe 21 beats/min, and palpation abdominal part finds that there is fetus and is stranded in intrauterine, through treatment, successfully takes out the fetus being detained.But, 2 days future trouble sheep fervescence to 41.5 ℃, vaginal orifice is flowed out dirty red secretions, and drinking-water and feed stop.Be diagnosed as acute endometritis, in vein fluid infusion, get above-mentioned prescription treatment, be used in conjunction 3 doses, sb.'s illness took a favorable turn, and appetite and drink wish are recovered, and use again 2 doses, discontinue medication, and pay a return visit, and main suit fully recovers.
Between treatment case 5:2010 year JIUYUE in July to 2011, be total to diagnosis and treatment endometritis at Shandong Province's Laiyang City goat feed lot and suffer from 15 of sheep, wherein have 6 for acute endometritis, clinical symptoms shows as inappetence, fervescence, spirit is depressed, ruminate and weaken or stop, slight distension gas, flows out kermesinus juice in vaginal orifice, while keeping down output more, vaginal orifice is around often sticked secretions dry incrustation; Other 9 is chronic endometritis, and trouble sheep General Symptoms is not obvious, and appetite slightly subtracts, and lactation amount reduces, and discharges the juice that contains floccule from intravaginal, and the estrus cycle is normal, but Repeat breeding.Through above-mentioned composition treatment, acute 6 merely hit cures 5 (cure rate 83.3%), dead 1; Chronic 9 merely hit cures 6 (cure rate 77.8%), eliminates 3.
Table 2. uses the statistics of traditional Chinese medicine composition for treating sheep endometritis of the present invention
| Treatment case | Treatment number | Cure number | The dead number of washing in a pan | Cure rate % |
| 1 | 5 | 5 | 0 | 100 |
| 2 | 4 | 3 | 1 | 75 |
| 3 | 26 | 22 | 4 | 84.6 |
| 3 | 31 | 25 | 6 | 80.6 |
| 4 | 1 | 1 | 0 | 100 |
| 5 | 15 | 11 | 4 | 73.3 |
| Amount to | 82 | 67 | 15 | 81.7 |
Claims (2)
1. a Chinese medicine composition for the treatment of sheep endometritis, is characterized in that: meter by weight, and composed of the following components: 20-30 part Herba Senecionis Scandentis, 30-40 part Radix Sophorae Flavescentis, 30-40 part Radix Scutellariae, 30-40 part Rhizoma Coptidis, 30-40 part Rhizoma Atractylodis Macrocephalae, 30-40 part Herba Taraxaci, 30-40 part Herba Epimedii, 50-70 part Herba Leonuri, 50-70 part Radix Codonopsis, 50-70 part Herba Aristolochiae, 50-70 part Radix Angelicae Sinensis, 30-40 part Semen Vaccariae, 20-30 part Pollen Typhae, 20-30 part Radix Astragali, 20-30 part Radix Glycyrrhizae.
2. a preparation method for the treatment of the Chinese medicine composition of sheep endometritis, is characterized in that: comprise the following steps:
1. prepare medicament: take 20-30 part Herba Senecionis Scandentis, 30-40 part Radix Sophorae Flavescentis, 30-40 part Radix Scutellariae, 30-40 part Rhizoma Coptidis, 30-40 part Rhizoma Atractylodis Macrocephalae, 30-40 part Herba Taraxaci, 30-40 part Herba Epimedii, 50-70 part Herba Leonuri, 50-70 part Radix Codonopsis, 50-70 part Herba Aristolochiae, 50-70 part Radix Angelicae Sinensis, 30-40 part Semen Vaccariae, 20-30 part Pollen Typhae, 20-30 part Radix Astragali, 20-30 part Radix Glycyrrhizae;
2. boil medicament: in the medicament 1. preparing to step, add 2500-3000 part normal-temperature water, soak 30 minutes; After intense fire boils, adopt slow fire to continue to decoct 40-50 minute, filter, obtain medicinal residues and a medicinal liquid; In described medicinal residues, add again 2000-2500 part normal-temperature water, adopt 40-45 minute at a simmer, filter, obtain secondary medicinal liquid; Medicinal liquid and secondary medicinal liquid are merged, obtain the Chinese medicine composition of potion treatment sheep endometritis.
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| CN104958703A (en) * | 2015-07-17 | 2015-10-07 | 战汪涛 | Pharmaceutical composition for treating chronic endometritis of sheep and preparation method of pharmaceutical composition |
| CN106692343A (en) * | 2017-01-11 | 2017-05-24 | 永安市仁迈信息技术服务有限公司 | Traditional Chinese medicine preparation for treating endometritis of black sheep, and preparation method and application thereof |
| CN107951972A (en) * | 2017-11-27 | 2018-04-24 | 青岛农业大学 | Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof |
| CN110938619A (en) * | 2019-12-19 | 2020-03-31 | 北京农学院 | Immobilized enzyme transformed radix scutellariae and application thereof in repairing acetaminophen damage |
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| CN101396464A (en) * | 2008-11-06 | 2009-04-01 | 武瑞 | Traditional Chinese medicine composition for treating cow endometritis |
| CN101623056A (en) * | 2009-07-31 | 2010-01-13 | 山西天沐合生农牧科技开发有限公司 | Chinese herbal medicine feed additive for ewes |
| CN102114171A (en) * | 2009-12-31 | 2011-07-06 | 天津瑞普生物技术股份有限公司 | Traditional Chinese medicine composition for treating cow endometritis |
| CN102578430A (en) * | 2012-03-20 | 2012-07-18 | 天津市畜牧兽医研究所 | Nutrition regulating and controlling additive special for dairy cattle in perinatal period |
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| CN101396464A (en) * | 2008-11-06 | 2009-04-01 | 武瑞 | Traditional Chinese medicine composition for treating cow endometritis |
| CN101623056A (en) * | 2009-07-31 | 2010-01-13 | 山西天沐合生农牧科技开发有限公司 | Chinese herbal medicine feed additive for ewes |
| CN102114171A (en) * | 2009-12-31 | 2011-07-06 | 天津瑞普生物技术股份有限公司 | Traditional Chinese medicine composition for treating cow endometritis |
| CN102578430A (en) * | 2012-03-20 | 2012-07-18 | 天津市畜牧兽医研究所 | Nutrition regulating and controlling additive special for dairy cattle in perinatal period |
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