CN104288273B - Treat Chinese and western medicinal composition of eperythrozoonosis in dairy cow and preparation method thereof - Google Patents

Treat Chinese and western medicinal composition of eperythrozoonosis in dairy cow and preparation method thereof Download PDF

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Publication number
CN104288273B
CN104288273B CN201410537480.5A CN201410537480A CN104288273B CN 104288273 B CN104288273 B CN 104288273B CN 201410537480 A CN201410537480 A CN 201410537480A CN 104288273 B CN104288273 B CN 104288273B
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China
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chinese
eperythrozoonosis
parts
medicinal composition
dairy cow
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CN104288273A (en
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李迎梅
陈庆忠
安同伟
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Ma Xiaoli
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Tianjin Rebate Science and Technology Development Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/655Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to a kind of Chinese and western medicinal composition for treating eperythrozoonosis in dairy cow, the component and its ratio of weight and number of its composition are respectively:0.1 03 parts of Benny's that;0.4 1 parts of imidazophenylurea hydrochloride;5 15 parts of Chinese ephedra;10 30 parts of almond;15 40 parts of lepidium seed;20 50 parts of sweet wormwood;10 40 parts of oriental wormwood;0.5 10 parts of gypsum.The present invention both from the synthesis and duplication of molecular level selective exclusion eperythrozoon inhereditary material, and can produce irreversibility to combine, so that it disappears, can not schizogamy;Meanwhile, its traditional Chinese medicine ingredients can alleviate heat temperature hold under the arm it is wet, have functions that yin-nourishing is diathermanous, prevent it is evil enter ying blood etc. treat both principal and secondary aspect of disease, short treating period, security is good, easy to use, easily absorbs, and is a kind of Chinese and western medicinal composition of ideal treatment eperythrozoonosis in dairy cow.

Description

Treat Chinese and western medicinal composition of eperythrozoonosis in dairy cow and preparation method thereof
Technical field
The invention belongs to field of veterinary, especially a kind of Chinese and western medicinal composition and its system for treating eperythrozoonosis in dairy cow Preparation Method.
Background technology
Eperythrozoonosis is during eperythrozoon parasitizes erythrocyte surface, blood plasma, tissue fluid and cerebrospinal fluid, to cause poor A kind of disease of the infecting both domestic animals and humans of symptom such as blood, jaundice heating.Countries in the world to its history of life, route of transmission, pathogenesis and Molecular biological characteristic etc. is not fully aware of, wherein health of the eperythrozoonosis in dairy cow serious harm to milk cow production Stable development, there is no a kind of active drug that the eperythrozoon in Contents in Cows is fully erased, antibiotics alone, this disease compared with Easily repeatedly, alone Chinese herbal medicine, curative effect is again too slow, and the course of disease is more long, extremely easily damages milk cow physiological function.
The content of the invention
It is an object of the invention to provide a kind of Chinese and western medicinal composition for treating eperythrozoonosis in dairy cow, said composition tool Play the role of to treat eperythrozoonosis in dairy cow well, and easy to use, short treating period, cost is relatively low.
It is another object of the present invention to provide a kind of system of the Chinese and western medicinal composition for treating eperythrozoonosis in dairy cow Preparation Method.
What the present invention was achieved through the following technical solutions:
A kind of Chinese and western medicinal composition for treating eperythrozoonosis in dairy cow, the component and its parts by weight of its composition Than being respectively:
And, the component of composition and its optimal ratio of weight and number are respectively:
A kind of preparation method of the Chinese and western medicinal composition for treating eperythrozoonosis in dairy cow, its preparation methods steps are:
(1) Chinese ephedra, almond, lepidium seed, sweet wormwood and oriental wormwood is weighed respectively by weight ratio to be crushed, it is complete respectively after crushing Portion adds gypsum to be ground to obtain Chinese medicine mixing smalls by weight ratio by 80 mesh sieves;
(2) weigh Benny's that respectively by weight ratio and imidazophenylurea hydrochloride mixes carefully with the Chinese medicine after grinding in step (1) End is put into blending tank and is sufficiently mixed uniform, that is, the Chinese and western medicinal composition finished product of the eperythrozoonosis in dairy cow that obtains medical treatment.
Advantages of the present invention and beneficial effect are:
1st, you, imidazophenylurea hydrochloride, Ke Yicong of the Benny in the Chinese and western medicinal composition of this treatment eperythrozoonosis in dairy cow The synthesis and duplication of molecular level selective exclusion eperythrozoon inhereditary material, and produce irreversibility to combine, so that its Disappear, can not schizogamy;Chinese ephedra, almond and gypsum clearing heat-fire, cough and asthma relieving efficacy are obvious;Sweet wormwood, oriental wormwood and ground While bone skin purging the lung of pathogenic fire sending down abnormally ascending, inducing diuresis for removing edema, can it is diathermanous with yin-nourishing, prevent heresy from entering ying blood, disease in control;Treat both principal and secondary aspect of disease, prevent Only eperythrozoonosis causes serial hot summer weather syndrome and consumes and hinder milk cow body functional activities of the body fluid.
2nd, broad-spectrum high efficacy of the present invention, to hydrochloric acid in gastric juice quite stable, absorbs good after taking orally, is not influenceed by water temperature, acid-base value, together When blood peak concentration of drug is just can reach in extremely low concentration and in the short period.
Specific embodiment
The present invention is described in further detail by following examples.It should be noted that:Following embodiments are illustrative, are not Limited, it is impossible to limit protection scope of the present invention with following embodiments.
Embodiment 1
A kind of Chinese and western medicinal composition for treating eperythrozoonosis in dairy cow, the component and its weight point of its Chinese and western medicinal composition It is not:Benny's that 1g, imidazophenylurea hydrochloride 4g, Chinese ephedra 50g, almond 100g, lepidium seed 150g, sweet wormwood 200g, oriental wormwood 100g, life Gypsum 5g.
The step of a kind of preparation method of the Chinese and western medicinal composition for treating eperythrozoonosis in dairy cow, preparation method, is as follows:
(1) Chinese ephedra, almond, lepidium seed, sweet wormwood and oriental wormwood is weighed respectively by weight ratio to be crushed, it is complete respectively after crushing Portion adds gypsum to be ground to obtain Chinese medicine mixing smalls by weight ratio by 80 mesh sieves;
(2) weigh Benny's that respectively by weight ratio and imidazophenylurea hydrochloride mixes carefully with the Chinese medicine after grinding in step (1) End is put into blending tank and is sufficiently mixed uniform, that is, the Chinese and western medicinal composition finished product of the eperythrozoonosis in dairy cow that obtains medical treatment.
Embodiment 2
A kind of Chinese and western medicinal composition for treating eperythrozoonosis in dairy cow, the component and its weight point of its Chinese and western medicinal composition It is not:Benny your 3g, imidazophenylurea hydrochloride 10g, Chinese ephedra 150g, almond 300g, lepidium seed 400g, sweet wormwood 500g, oriental wormwood 400g, Gypsum 100g.
The step of its preparation method, is with embodiment 1.
Embodiment 3
A kind of Chinese and western medicinal composition for treating eperythrozoonosis in dairy cow, the component and its weight point of its Chinese and western medicinal composition It is not:Benny's that 2g, imidazophenylurea hydrochloride 5g;Chinese ephedra 100g, almond 200g, lepidium seed 250g, sweet wormwood 300g, oriental wormwood 300g, Gypsum 50g.
The step of its preparation method, is with embodiment 1.
Application method of the invention, warm boiled water takes this product orally and can reach treatment by the amount of adult dairy cattle 1g/Kg body weight The effect of disease.
The test of pesticide effectiveness
1st, diagnosis and treatment are carried out to 39 eperythrozoon milk cows, random point of 4 groups, blank control group 3, remaining every group 12; Treatment group i.e. of the present invention, Chinese medicine control group, western medicine group, blank control group.
2nd, dosage is treatment group of the present invention for oral administration by the amount administration of 1g/Kg body weight, and Western medicine is exclusive use Benny's that Control group presses medicine explanation administration, and Chinese medicine is Ma Xing Shi Gan Tang (market is used to treat eperythrozoonosis) by 1g/Kg body weight Clothes, are once every three days observed afterwards, and blank control group is not administered carries out observation three to four days, and the condition of the injury to each group milk cow is seen Examine.Result such as following table:
Table 1:Mammitis group
In upper table, the healing rate for the treatment of group of the present invention is 100%, and the healing rate of Chinese medicine group and Western medicine group is not enough 70%, the healing rate of blank control group is 0%, it is seen that the extremely difficult dependence body autoimmunity of milk cow with eperythrozoonosis It is voluntarily more complete.Advantage of the invention is that there is insecticidal effect simultaneously in table, treat both principal and secondary aspect of disease, it is very big to shorten the course for the treatment of, effect Preferably.

Claims (3)

1. a kind of Chinese and western medicinal composition for treating eperythrozoonosis in dairy cow, it is characterised in that:The component and its weight of said composition Amount portion rate is respectively:
2. it is according to claim 1 treatment eperythrozoonosis in dairy cow Chinese and western medicinal composition, it is characterised in that:The combination The component of thing and its optimal ratio of weight and number are respectively:
3. a kind of preparation method of the Chinese and western medicinal composition for the treatment of eperythrozoonosis in dairy cow as claimed in claim 1, it is special Levy and be:The preparation method step is:
(1) Chinese ephedra, almond, lepidium seed, sweet wormwood and oriental wormwood is weighed respectively by weight ratio to be crushed, it is all logical respectively after crushing 80 mesh sieves are crossed, and adds gypsum to be ground to obtain Chinese medicine mixing smalls by weight ratio;
(2) weigh Benny's that respectively by weight ratio and imidazophenylurea hydrochloride is put with the Chinese medicine mixing smalls after grinding in step (1) Enter and be sufficiently mixed in blending tank uniform, that is, the Chinese and western medicinal composition finished product of the eperythrozoonosis in dairy cow that obtains medical treatment.
CN201410537480.5A 2014-10-13 2014-10-13 Treat Chinese and western medicinal composition of eperythrozoonosis in dairy cow and preparation method thereof Expired - Fee Related CN104288273B (en)

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CN104784167B (en) * 2015-04-02 2017-08-15 河南黑马动物药业有限公司 A kind of medicine for treating animal eperythrozoonosis and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN103272085A (en) * 2013-05-27 2013-09-04 东北农业大学 Traditional Chinese medicine composition for treating eperythrozoonosis of dairy cows and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103272085A (en) * 2013-05-27 2013-09-04 东北农业大学 Traditional Chinese medicine composition for treating eperythrozoonosis of dairy cows and preparation method thereof

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* Cited by examiner, † Cited by third party
Title
中西医结合诊治奶牛附红细胞体病;郭宏军等,;《中国奶牛》;20121231;第57-58页 *

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Inventor after: Ma Xiaoli

Inventor before: Li Yingmei

Inventor before: Chen Qingzhong

Inventor before: An Tongwei

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Effective date of registration: 20180117

Address after: 448299 Shayang Town, Shayang County, Jingmen, Hubei Province, No. 18 No. two street

Patentee after: Ma Xiaoli

Address before: 300384 Tianjin city Alex Hua Tian Huayuan Industrial Zone Binhai Road No. 6, building H, room -802, Haitai

Patentee before: TIANJIN REBATE SCIENCE & TECHNOLOGY DEVELOPMENT Co.,Ltd.

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