CN101810700A - Effervescent traditional Chinese medicine composition with function of freeing lung and relieving asthma and preparation method thereof - Google Patents
Effervescent traditional Chinese medicine composition with function of freeing lung and relieving asthma and preparation method thereof Download PDFInfo
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- CN101810700A CN101810700A CN200910228300A CN200910228300A CN101810700A CN 101810700 A CN101810700 A CN 101810700A CN 200910228300 A CN200910228300 A CN 200910228300A CN 200910228300 A CN200910228300 A CN 200910228300A CN 101810700 A CN101810700 A CN 101810700A
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Abstract
The invention relates to an effervescent traditional Chinese medicine composition with the function of freeing lung and relieving asthma and a preparation method thereof. The effervescent traditional Chinese medicine composition comprises the components and the weight percent thereof: 10-30% of ephedra herb, 10-30% of bitter apricot seed, 10-30% of gypsum, 10-30% of liquorice, 10-30% of effervescing agent and 5-30% of lubricating agent. The effervescent traditional Chinese medicine composition has scientific and reasonable formulation composition, can be effectively used for treating the disease of lung heat cough and asthma in cultivation of livestock and poultry, has no toxic and side effect and drug residue, simplifies the operation, saves the cultivation cost, is convenient for use and rapid in effect, can effectively kill and inhibit bacteria, is high in bioavailability, and meets the requirements of safe veterinary drug and guaranteeing the safety of food of animal origin.
Description
Technical field
The invention belongs to poultry and use field of veterinary, especially a kind of effervescent Chinese medicinal composition and preparation method thereof with depressed lung-energy dispersing function.
Background technology
China is livestock and poultry cultivation big country, and the R﹠D work of treatment livestock and poultry medicine did not all stop all the time.In the face of the market trend who becomes better and better, countries in the world require also more and more higher to edible safety, along with progress of science and technology, increasing drug residue is detected and confirms health harmful, countries in the world are all in the supervision that strengthens the residual problem of medicine, this has also produced no small impact to China's livestock and poultry breeding industry, and has proposed a urgent problem.The theory of scientific culture also is rooted in the hearts of the people simultaneously, simplifies and cultures operation, saves aquaculture cost and has become the current problem of being concerned about most of raiser.
Summary of the invention
The object of the present invention is to provide a kind of effervescent Chinese medicinal composition with depressed lung-energy dispersing function, this Chinese medicine composition can effectively be treated lung-heat disease of cough and asthma in the livestock and poultry cultivation, have no side effect and drug residue, simplify the operation, save aquaculture cost, easy to use, onset is rapid, can effectively kill virus antibacterial and bioavailability high.
Another object of the present invention is to provide a kind of preparation method with effervescent Chinese medicinal composition of depressed lung-energy dispersing function.
The present invention is achieved by the following technical solutions:
A kind of effervescent Chinese medicinal composition with depressed lung-energy dispersing function, the component of its effervescent Chinese medicinal composition and percentage by weight thereof are:
Herba Ephedrae 10-30%;
Semen Armeniacae Amarum 10-30%;
Gypsum Fibrosum 10-30%;
Radix Glycyrrhizae 10-30%;
Effervescent 10-30%;
Lubricant 5-30%.
And described effervescent is combined by weight 1: 1 by the wherein a kind of and sodium bicarbonate in tartaric acid, citric acid, the adipic acid.
And described lubricant is wherein a kind of in sucralose, erythritol, magnesium stearate, the dodecyl sodium sulfate.
A kind of preparation method with effervescent Chinese medicinal composition of depressed lung-energy dispersing function, the step of its preparation method is:
(1) take by weighing Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae according to weight proportion, pulverize difference all by behind 80 mesh sieves, mix homogeneously obtains mixture A;
(2) take by weighing effervescent, lubricant according to weight proportion and pulverize respectively respectively all by behind 80 mesh sieves with mixture A mix homogeneously, obtain mixture B;
(3) be binding agent system soft material with mixture B with concentration 50～60% alcoholic solution of 2～4%PVP, with soft material all by 10～15 mesh sieve system granules, under 50～60 ℃, carry out aeration-drying, all make granulate by 20～30 mesh sieves, tabletting promptly obtains the effervescent Chinese medicinal composition that finished product has the depressed lung-energy dispersing function then.
Advantage of the present invention and beneficial effect are:
1, this effervescent Chinese medicinal composition is introduced the effervescent technology in the tablet of this medicine into cleverly, save a large amount of manpower and materials, effective ingredient in the medicine is dissolved rapidly and uniformly, being convenient to poultry absorbs, improve bioavailability, can significantly improve the clinical efficacy of medicine, the effervescent The Application of Technology has been saved aquaculture cost, only need in fowl drinking water, to throw in to get final product, simplified operation.
2, in this effervescent Chinese medicinal composition with Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae as the natural Chinese medicine composition, have good heat-clearing and toxic substances removing, the depressed lung-energy dispersing effect.As the natural Chinese medicines extract, do not have any poisonous and harmful substance simultaneously, can not produce toxic and side effects, more can not exert an influence health to animal body.
3, the present invention fill a prescription form scientific and reasonable, can effectively treat lung-heat disease of cough and asthma in the livestock and poultry cultivation, have no side effect and drug residue, simplify the operation, save aquaculture cost, easy to use, onset is rapid, can effectively kill virus antibacterial and bioavailability high, meet safe veterinary drug, ensure the animal-derived food safe requirement.
The specific embodiment
The present invention is described in further detail by following examples.Need to prove: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Herba Ephedrae in the component of the present invention, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, tartaric acid, citric acid, adipic acid, sodium bicarbonate, sucralose, erythritol, magnesium stearate, dodecyl sodium sulfate all can be bought on market and obtain.
Embodiment 1
A kind of effervescent Chinese medicinal composition with depressed lung-energy dispersing function, the component and the weight of its effervescent Chinese medicinal composition are respectively: Herba Ephedrae 20Kg, Semen Armeniacae Amarum 20Kg, Gypsum Fibrosum 10Kg, Radix Glycyrrhizae 20Kg, effervescent 20Kg, lubricant 10Kg; Above-mentioned effervescent is made up of citric acid 10Kg and sodium bicarbonate 10Kg, and lubricant is a magnesium stearate.
A kind of preparation method with effervescent Chinese medicinal composition of depressed lung-energy dispersing function, the step of its preparation method is:
(1) take by weighing Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae pulverizing respectively all by behind 80 mesh sieves according to weight proportion, mix homogeneously obtains mixture A;
(2) according to weight proportion take by weighing effervescent, lubricant pulverize respectively respectively all by behind 80 mesh sieves with mixture A mix homogeneously, obtain mixture B;
(3) be binding agent system soft material with mixture B with 50 alcoholic solution of 2PVP, with soft material all by 10 mesh sieve system granules, carry out aeration-drying under 50 ℃, all make granulate by 20 mesh sieves, tabletting promptly obtains the effervescent Chinese medicinal composition that finished product has the depressed lung-energy dispersing function then.
Embodiment 2
A kind of effervescent Chinese medicinal composition with depressed lung-energy dispersing function, the component and the weight of its effervescent Chinese medicinal composition are respectively: Herba Ephedrae 15Kg, Semen Armeniacae Amarum 15Kg, Gypsum Fibrosum 10Kg, Radix Glycyrrhizae 20Kg, effervescent 30Kg, lubricant 10Kg; Above-mentioned effervescent is made up of, adipic acid 15Kg and sodium bicarbonate 15Kg, and lubricant is an erythritol.
A kind of preparation method with effervescent Chinese medicinal composition of depressed lung-energy dispersing function, the step of its preparation method is:
(1) take by weighing Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae pulverizing respectively all by behind 80 mesh sieves according to weight proportion, mix homogeneously obtains mixture A;
(2) according to weight proportion take by weighing effervescent, lubricant pulverize respectively respectively all by behind 80 mesh sieves with mixture A mix homogeneously, obtain mixture B;
(3) be binding agent system soft material with mixture B with 60% alcoholic solution of 4%PVP, with soft material all by 15 mesh sieve system granules, carry out aeration-drying under 60 ℃, all make granulate by 30 mesh sieves, tabletting promptly obtains the effervescent Chinese medicinal composition that finished product has the depressed lung-energy dispersing function then.
Embodiment 3
A kind of effervescent Chinese medicinal composition with depressed lung-energy dispersing function, the component and the weight of its effervescent Chinese medicinal composition are respectively: Herba Ephedrae 20Kg, Semen Armeniacae Amarum 20Kg, Gypsum Fibrosum 20Kg, Radix Glycyrrhizae 20Kg, effervescent 15Kg, lubricant 5Kg; Above-mentioned effervescent is made up of tartaric acid 7.5Kg and sodium bicarbonate 7.5Kg, and lubricant is a dodecyl sodium sulfate.
The step of its preparation method is with embodiment 1.
Embodiment 4
A kind of effervescent Chinese medicinal composition with depressed lung-energy dispersing function, the component and the weight of its effervescent Chinese medicinal composition are respectively: Herba Ephedrae 20Kg, Semen Armeniacae Amarum 20Kg, Gypsum Fibrosum 10Kg, Radix Glycyrrhizae 20Kg, effervescent 25Kg, lubricant 5Kg; Above-mentioned effervescent is made up of citric acid 12.5Kg and sodium bicarbonate 12.5Kg, and lubricant is a sucralose.
The step of its preparation method is with embodiment 1.
Embodiment 5
A kind of effervescent Chinese medicinal composition with depressed lung-energy dispersing function, the component and the weight of its effervescent Chinese medicinal composition are respectively: Herba Ephedrae 20Kg, Semen Armeniacae Amarum 20Kg, Gypsum Fibrosum 10Kg, Radix Glycyrrhizae 30Kg, effervescent 10Kg, lubricant 10Kg; Above-mentioned effervescent is made up of citric acid 5Kg and sodium bicarbonate 5Kg, and lubricant is a magnesium stearate.
The step of its preparation method is with embodiment 1.
Originally the effervescent Chinese medicinal composition that has the depressed lung-energy dispersing function does not need dissolving in advance in application, directly drop into and culture in the fowl drinking water, and the per kilogram water body gets final product with this effervescent Chinese medicinal composition 1 gram-10 grams.
The clinical practice experiment
1, experimental technique
Select 200 of the broiler of not morbidity to be divided into two groups at random, one group is adopted common Maxingshigan sheet to prevent, and one group is prevented with the present invention; Selection has 200 of the broiler of asthma and cough symptom to be divided into two groups at random, and one group is adopted common Maxingshigan sheet to treat, treats with the present invention for one group.
2, experimental result
The morbidity rehabilitation situation of testing with pig through the primary part observation record obtains the result, and the experiment of prevention group all is effectively controlled with the pig incidence, and the state of an illness does not have further spreading trend; Treatment group therapeutic effect is obvious, adopts experimental group cure rate of the present invention to reach 99%, improves 15% than the experimental group that adopts common Maxingshigan sheet.With SPSS12.0 statistics software analysis, behind the administration 5d, treatment group and matched group cure rate significant difference (p＜0.05).
The characteristic of component among the present invention
1, Herba Ephedrae: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Be used for anemofrigid cold, uncomfortable in chest breathing with cough, edema due to wind pathogen edema; Bronchial asthma.Honey Herba Ephedrae nourishing the lung to arrest cough is used for showing disease more and separates asthma and cough.
2, Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
3, Semen Armeniacae Amarum: contain amygdaloside in the Semen Armeniacae Amarum, amygdaloside can be produced the hydrocyanic acid and the benzaldehyde of trace by enteric microorganism enzyme or the contained emulsin hydrolysis of Semen Armeniacae Amarum itself in vivo, and respiratory center is had inhibitory action, reaches antitussive, antiasthmatic effect.The Semen Armeniacae Amarum bitter in the mouth therapeutic method to keep the adverse QI flowing downwards, and be rich in fatty oil.Fatty oil can improve the lubrication of intestinal contents to mucosa, so Semen Armeniacae Amarum has the function of loosening bowel to relieve constipation.Amygdaloside also produces benzaldehyde when the enzyme effect is decomposed to form hydrocyanic acid, and the latter can suppress pepsic activity, thereby influences digestive function
4, Gypsum Fibrosum: control the calentura high fever and do not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, the lung-heat dyspnea with rapid respiration, the heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat is sent out the speckle dermexanthesis, aphtha of the mouth and tongue.Forge deposited promoting tissue regeneration and ulcer healing.The external treatment ulcer sores is burst and is not closed up the burning hot wound of soup.
5, effervescent tablet is a kind of novel tablet of external in recent years Application and Development, the difference of it and conventional tablet, just be that it also contains gas-producing disintegrant, after effervescent tablet is put into water, under the effect of gas-producing disintegrant, produce a large amount of bubbles (carbon dioxide) at once, make rapid disintegrate of tablet and thawing, sometimes the bubble that disintegrate produces also can make tablet roll up and down in water, quickens its disintegrate and thawing.
Claims (4)
1. effervescent Chinese medicinal composition with depressed lung-energy dispersing function, it is characterized in that: the component of this effervescent Chinese medicinal composition and percentage by weight thereof are:
Herba Ephedrae 10-30%;
Semen Armeniacae Amarum 10-30%;
Gypsum Fibrosum 10-30%;
Radix Glycyrrhizae 10-30%;
Effervescent 10-30%;
Lubricant 5-30%.
2. the effervescent Chinese medicinal composition with depressed lung-energy dispersing function according to claim 1 is characterized in that: described effervescent is combined by weight 1: 1 by the wherein a kind of and sodium bicarbonate in tartaric acid, citric acid, the adipic acid.
3. the effervescent Chinese medicinal composition with depressed lung-energy dispersing function according to claim 1 is characterized in that: described lubricant is wherein a kind of in sucralose, erythritol, magnesium stearate, the dodecyl sodium sulfate.
4. preparation method with effervescent Chinese medicinal composition of depressed lung-energy dispersing function as claimed in claim 1, it is characterized in that: the step of this preparation method is:
(1) take by weighing Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae according to weight proportion, pulverize difference all by behind 80 mesh sieves, mix homogeneously obtains mixture A;
(2) take by weighing effervescent, lubricant according to weight proportion and pulverize respectively respectively all by behind 80 mesh sieves with mixture A mix homogeneously, obtain mixture B;
(3) be binding agent system soft material with mixture B with concentration 50～60% alcoholic solution of 2～4%PVP, with soft material all by 10～15 mesh sieve system granules, under 50～60 ℃, carry out aeration-drying, all make granulate by 20～30 mesh sieves, tabletting promptly obtains the effervescent Chinese medicinal composition that finished product has the depressed lung-energy dispersing function then.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910228300A CN101810700A (en) | 2009-11-16 | 2009-11-16 | Effervescent traditional Chinese medicine composition with function of freeing lung and relieving asthma and preparation method thereof |
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| CN200910228300A CN101810700A (en) | 2009-11-16 | 2009-11-16 | Effervescent traditional Chinese medicine composition with function of freeing lung and relieving asthma and preparation method thereof |
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| CN101810700A true CN101810700A (en) | 2010-08-25 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142724A (en) * | 2013-03-29 | 2013-06-12 | 成都乾坤动物药业有限公司 | Veterinary ephedra-almond-gypsum-licorice chewable tablet and preparation process thereof |
| CN104189152A (en) * | 2014-09-01 | 2014-12-10 | 山东明发兽药股份有限公司 | Ephedra, semen armeniacae amarae, gypsum and liquorice effervescent granules and preparation method thereof |
| CN105748644A (en) * | 2014-12-19 | 2016-07-13 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicine composition with effects of stopping cough and relieving asthma and preparation method of traditional Chinese medicine composition |
| CN105748642A (en) * | 2014-12-19 | 2016-07-13 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicinal composition for suppressing cough and relieving asthma, and preparation method thereof |
| CN105748641A (en) * | 2014-12-19 | 2016-07-13 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicinal composition for suppressing cough and relieving asthma, and preparation method thereof |
-
2009
- 2009-11-16 CN CN200910228300A patent/CN101810700A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142724A (en) * | 2013-03-29 | 2013-06-12 | 成都乾坤动物药业有限公司 | Veterinary ephedra-almond-gypsum-licorice chewable tablet and preparation process thereof |
| CN103142724B (en) * | 2013-03-29 | 2015-06-10 | 成都乾坤动物药业有限公司 | Veterinary ephedra-almond-gypsum-licorice chewable tablet and preparation process thereof |
| CN104189152A (en) * | 2014-09-01 | 2014-12-10 | 山东明发兽药股份有限公司 | Ephedra, semen armeniacae amarae, gypsum and liquorice effervescent granules and preparation method thereof |
| CN105748644A (en) * | 2014-12-19 | 2016-07-13 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicine composition with effects of stopping cough and relieving asthma and preparation method of traditional Chinese medicine composition |
| CN105748642A (en) * | 2014-12-19 | 2016-07-13 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicinal composition for suppressing cough and relieving asthma, and preparation method thereof |
| CN105748641A (en) * | 2014-12-19 | 2016-07-13 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicinal composition for suppressing cough and relieving asthma, and preparation method thereof |
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Open date: 20100825 |