CN101816724A - Effervescent traditional Chinese medicine composition having dampness removing and diarrhea-relieving function and preparation method thereof - Google Patents
Effervescent traditional Chinese medicine composition having dampness removing and diarrhea-relieving function and preparation method thereof Download PDFInfo
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- CN101816724A CN101816724A CN200910228403A CN200910228403A CN101816724A CN 101816724 A CN101816724 A CN 101816724A CN 200910228403 A CN200910228403 A CN 200910228403A CN 200910228403 A CN200910228403 A CN 200910228403A CN 101816724 A CN101816724 A CN 101816724A
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Abstract
The invention relates to an effervescent traditional Chinese medicine composition having dampness removing and diarrhea-relieving function and a preparation method thereof. The effervescent traditional Chinese medicine composition contains the following ingredients by weight percents: 5-30% of coptis root; 5-30% of cortex phellodendri; 10-30% of rhubarb; 5-30% of radix scutellariae; 10-30% of isatis root; 5-30% of liquorice; 10-30% of effervescing agent and 5-20% of lubricating agent. The effervescent traditional Chinese medicine composition has the advantages of scientific and reasonable formulation, no toxic and side effect as well as residual medicine, simplified operations, saved cultivation cost, convenient operation, fast effectiveness and high bioavailability, and can effectively achieve sterilization and bacterial inhibition.
Description
Technical field
The invention belongs to poultry and use field of veterinary, especially a kind of effervescent Chinese medicinal composition and preparation method thereof with dampness removing and diarrhea-relieving function.
Background technology
China is livestock and poultry cultivation big country, and the R﹠D work of treatment livestock and poultry medicine did not all stop all the time.In the face of the market trend who becomes better and better, countries in the world require also more and more higher to edible safety, along with progress of science and technology, increasing drug residue is detected and confirms health harmful, countries in the world are all in the supervision that strengthens the residual problem of medicine, this has also produced no small impact to China's livestock and poultry breeding industry, and has proposed a urgent problem.The theory of scientific culture also is rooted in the hearts of the people simultaneously, simplifies and cultures operation, saves aquaculture cost and has become the current problem of being concerned about most of raiser.It is the disease of cardinal symptom that poultry is taken place with diarrhoea, if take the treatment measure untimely, often causes poult death easily, and teleoptile is lost flesh, and weightening finish reduces, and Time To Market is postponed, and the poultry premunition descends, and causes enormous economic loss to the raiser.Through lot of experiments, cause poultry diarrheal reason to be mainly: (1) bacterial diarrhea: escherichia coli, clostridieum welchii enteritis, dysentery bacterium, interior Lawson Salmonella etc.; (2) viral diarrhea: transmissible gastroenteritis, epidemic diarrhea, rotavirus, Pseudorabies virus etc.; (3) parasitic diarrhea: ascarid, coccidiosis, whipworm, balantidium Coli etc.; (4) non-infective agent: temperature, hypoglycemia also claim hunger property diarrhoea, daily ration antigen allergic diarrhea also to claim soybean allergy, avirulence Hakuri also to claim iron deficiency diarrhoea or enzyme stomach function regulating subacidity Hakuri; Above-mentioned various diarrhoea Differential Diagnosis method is mainly (1) and judges according to the diarrhoea degree: if fulminating, fast-spreading diarrhoea then is viral diarrhea; If recessiveness takes place, slowly disseminates, increases the weight of in time, then be bacillary or parasitic diarrhea; (2) judge according to the acid-base value and the character of feces: the feces of viral diarrhea mostly is acid, and other diarrheal feces mostly are alkalescence; Water sample is spurting diarrhoea is caused by virus that mostly sticking shape or pasty state have foamed feces and caused by antibacterial mostly; Pasty state, yellow-gray, malodorous feces mostly are coccidiosis property diarrhoea greatly; (3) according to whether judging in the feces: draw the feces of black pitch sample mostly to be gastric ulcer with blood; Draw cherry feces mostly to be dysentery, whipworm.
Summary of the invention
The object of the present invention is to provide a kind of effervescent Chinese medicinal composition with dampness removing and diarrhea-relieving function, this Chinese medicine composition has no side effect and drug residue, simplifies the operation, and saves aquaculture cost, easy to use, onset is rapid, can effectively kill virus antibacterial and bioavailability high.
Another object of the present invention is to provide a kind of preparation method with effervescent Chinese medicinal composition of dampness removing and diarrhea-relieving function.
The present invention is achieved by the following technical solutions:
A kind of effervescent Chinese medicinal composition with dampness removing and diarrhea-relieving function, the component of its effervescent Chinese medicinal composition and percentage by weight thereof are:
Rhizoma Coptidis 5-30%; Cortex Phellodendri 5-30%;
Radix Et Rhizoma Rhei 10-30%; Radix Scutellariae 5-30%;
Radix Isatidis 10-30%; Radix Glycyrrhizae 5-30%;
Effervescent 10-30%; Lubricant 5-20%.
And described effervescent is combined by weight 1: 1 by the wherein a kind of and sodium bicarbonate in tartaric acid, citric acid, the adipic acid.
And described lubricant is wherein a kind of in sucralose, erythritol, magnesium stearate, the dodecyl sodium sulfate.
A kind of preparation method with effervescent Chinese medicinal composition of dampness removing and diarrhea-relieving function, the step of its preparation method is:
(1) taking by weighing Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Radix Glycyrrhizae according to weight proportion decocts with water twice, two hours for the first time, one hour for the second time, collecting decoction, filter, it is 1.32～1.35 thick paste that filtrate is concentrated into relative density, drying, pulverize the back all by 80 mesh sieves, obtain mixture A;
(2) take by weighing effervescent, lubricant according to weight proportion and pulverize the back respectively, obtain mixture B all by the abundant mix homogeneously of mixture A in 80 mesh sieves and the step (1);
(3) be binding agent system soft material with mixture B with concentration 50～60% alcoholic solution of 2～4%PVP, and with soft material all by 10～15 mesh sieve system granules, under 50～60 ℃, carry out aeration-drying, all make granulate again, promptly obtain the effervescent Chinese medicinal composition that finished product has dampness removing and diarrhea-relieving function by 20～30 mesh sieves.
Advantage of the present invention and beneficial effect are:
1, in this effervescent Chinese medicinal composition with Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Radix Glycyrrhizae as the natural Chinese medicine composition, effect with good clearing away heat-fire, dysentery relieving, simultaneously as the natural Chinese medicines extract, there is not any poisonous and harmful substance, can not produce toxic and side effects, more can not exert an influence health to animal body.
2, this effervescent Chinese medicinal composition is introduced the effervescent technology in the granular preparation of this medicine into cleverly, save a large amount of manpower and materials, effective ingredient in the medicine is dissolved rapidly and uniformly, being convenient to poultry absorbs, improve bioavailability, can significantly improve the clinical efficacy of medicine, the effervescent The Application of Technology has been saved aquaculture cost, only need in fowl drinking water, to throw in to get final product, simplified operation.
3, the present invention fills a prescription and forms scientific and reasonablely, has no side effect and drug residue, simplifies the operation, and saves aquaculture cost, and is easy to use, onset is rapid, can effectively kill virus antibacterial and bioavailability high.
The specific embodiment
The present invention is described in further detail by following examples.Need to prove: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Rhizoma Coptidis in the component of the present invention, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Radix Glycyrrhizae, tartaric acid, citric acid, adipic acid, sodium bicarbonate, sucralose, erythritol, magnesium stearate, dodecyl sodium sulfate all can be bought on market and obtain.
Embodiment 1
A kind of effervescent Chinese medicinal composition with dampness removing and diarrhea-relieving function, the component and the weight of its effervescent Chinese medicinal composition are respectively: Rhizoma Coptidis 20Kg, Cortex Phellodendri 10Kg, Radix Et Rhizoma Rhei 10Kg, Radix Scutellariae 10Kg, Radix Isatidis 10Kg, Radix Glycyrrhizae 10Kg, effervescent 20Kg, lubricant 10Kg; Above-mentioned effervescent is made up of citric acid 10Kg and sodium bicarbonate 10Kg, and lubricant is a magnesium stearate.
A kind of preparation method with effervescent Chinese medicinal composition of dampness removing and diarrhea-relieving function, the step of its preparation method is:
(1) take by weighing Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Radix Glycyrrhizae according to weight proportion and decoct with water twice, two hours for the first time, one hour for the second time, collecting decoction filters, and it is 1.32 thick paste that filtrate is concentrated into relative density, drying is pulverized the back all by 80 mesh sieves, obtains mixture A;
(2) take by weighing effervescent, lubricant according to weight proportion and pulverize the back respectively, obtain mixture B all by the abundant mix homogeneously of mixture A in 80 mesh sieves and the step (1);
(3) be binding agent system soft material with mixture B with 50% alcoholic solution of 2%PVP, and with soft material all by 10 mesh sieve system granules, under 50 ℃, carry out aeration-drying, all make granulate again, promptly obtain the effervescent Chinese medicinal composition that finished product has dampness removing and diarrhea-relieving function by 20 mesh sieves.
Embodiment 2
A kind of effervescent Chinese medicinal composition with dampness removing and diarrhea-relieving function, the component and the weight of its effervescent Chinese medicinal composition are respectively: Rhizoma Coptidis 20Kg, Cortex Phellodendri 15Kg, Radix Et Rhizoma Rhei 15Kg, Radix Scutellariae 15Kg, Radix Isatidis 10Kg, Radix Glycyrrhizae 10Kg, effervescent 10Kg, lubricant 5Kg; Above-mentioned effervescent is made up of tartaric acid 5Kg and sodium bicarbonate 5Kg, and lubricant is an erythritol.
A kind of preparation method with effervescent Chinese medicinal composition of dampness removing and diarrhea-relieving function, the step of its preparation method is:
(1) take by weighing Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Radix Glycyrrhizae according to weight proportion and decoct with water twice, two hours for the first time, one hour for the second time, collecting decoction filters, and it is 1.35 thick paste that filtrate is concentrated into relative density, drying is pulverized the back all by 80 mesh sieves, obtains mixture A;
(2) take by weighing effervescent, lubricant according to weight proportion and pulverize the back respectively, obtain mixture B all by the abundant mix homogeneously of mixture A in 80 mesh sieves and the step (1);
(3) be binding agent system soft material with mixture B with 60% alcoholic solution of 4%PVP, and with soft material all by 15 mesh sieve system granules, under 60 ℃, carry out aeration-drying, all make granulate again, promptly obtain the effervescent Chinese medicinal composition that finished product has dampness removing and diarrhea-relieving function by 30 mesh sieves.
Embodiment 3
A kind of effervescent Chinese medicinal composition with dampness removing and diarrhea-relieving function, the component and the weight of its effervescent Chinese medicinal composition are respectively: Rhizoma Coptidis 10Kg, Cortex Phellodendri 5Kg, Radix Et Rhizoma Rhei 10Kg, Radix Scutellariae 10Kg, Radix Isatidis 20Kg, Radix Glycyrrhizae 10Kg, effervescent 30Kg, lubricant 5Kg; Above-mentioned effervescent is made up of adipic acid 15Kg and sodium bicarbonate 15Kg, and lubricant is a dodecyl sodium sulfate.
The step of its preparation method is with embodiment 1.
Embodiment 4
A kind of effervescent Chinese medicinal composition with dampness removing and diarrhea-relieving function, the component and the weight of its effervescent Chinese medicinal composition are respectively: Rhizoma Coptidis 5Kg, Cortex Phellodendri 5Kg, Radix Et Rhizoma Rhei 20Kg, Radix Scutellariae 20Kg, Radix Isatidis 20Kg, Radix Glycyrrhizae 15Kg, effervescent 10Kg, lubricant 5Kg; Above-mentioned effervescent is made up of citric acid 5Kg and sodium bicarbonate 5Kg, and lubricant is an erythritol.
The step of its preparation method is with embodiment 1.
Embodiment 5
A kind of effervescent Chinese medicinal composition with dampness removing and diarrhea-relieving function, the component and the weight of its effervescent Chinese medicinal composition are respectively: Rhizoma Coptidis 20Kg, Cortex Phellodendri 5Kg, Radix Et Rhizoma Rhei 20Kg, Radix Scutellariae 5Kg, Radix Isatidis 20Kg, Radix Glycyrrhizae 5Kg, effervescent 20Kg, lubricant 5Kg; Above-mentioned effervescent is made up of citric acid 10Kg and sodium bicarbonate 10Kg, and lubricant is a magnesium stearate.
The step of its preparation method is with embodiment 1.
Originally the effervescent Chinese medicinal composition that has dampness removing and diarrhea-relieving function does not need dissolving in advance in application, directly drop into and culture in the fowl drinking water, and the per kilogram water body gets final product with this effervescent Chinese medicinal composition 1 gram-10 grams.
The clinical practice experiment
1, experimental technique
200 of Luo Man egg breed chickens selecting 240 ages in days not fall ill are divided into two groups at random, and one group is adopted the plain particles agent to prevent, and one group is prevented with the present invention; Select 200 of the Luo Man egg breed chickens of 240 ages in days morbidity to be divided into two groups at random, one group is adopted the plain particles agent to treat, treats with the present invention for one group.
2, experimental result
The morbidity rehabilitation situation of testing with chicken through the primary part observation record obtains the result, and the experiment of prevention group all is effectively controlled with the chicken incidence, and the state of an illness does not have further spreading trend; Treatment group therapeutic effect is obvious, adopts experimental group cure rate of the present invention to reach 97%, improves 15% than the experimental group that adopts the plain particles agent.With SPSS12.0 statistics software analysis, behind the administration 5d, treatment group and matched group cure rate significant difference (p＜0.05).
The characteristic of component among the present invention
1, Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.Be used for conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Be used for cold and heat and tie mutually, damp and hot middle resistance, feeling of fullness vomiting.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.Be used for incoordination between the liver and stomach, the vomiting acid regurgitation.
2, Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
3, Radix Isatidis: maculae caused by violent heat pathogen; The hyperpyrexia headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, erysipelas, coma is told nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Can prevent and treat epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis.
4, Cortex Phellodendri: heat clearing and damp drying, pathogenic fire purging are removed and are steamed, and skin ulcer is treated in detoxifcation.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.The stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.Be used for hyperactivity of fire caused by deficiency of YIN, the night sweat hectic fever due to YIN-deficiency.
5, Radix Et Rhizoma Rhei: be the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheumtanguticum Maxim.ex Balf. or Rheum officinale Rheum officinale Baill..As medicine, has purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Be used for the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.Be used for the conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay eliminating fire and detoxication.Be used for pathogenic fire,toxin and furuncles.The hemostasis of charred Radix Et Rhizoma Rhei cooling blood and removing stasis.Be used for heat in blood stasis of blood bleeder is arranged.
6, Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, the hyperpyrexia excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement
7, effervescent tablet is a kind of novel tablet of external in recent years Application and Development, the difference of it and conventional tablet, just be that it also contains gas-producing disintegrant, after effervescent tablet is put into water, under the effect of gas-producing disintegrant, produce a large amount of bubbles (carbon dioxide) at once, make rapid disintegrate of tablet and thawing, sometimes the bubble that disintegrate produces also can make tablet roll up and down in water, quickens its disintegrate and thawing.
Claims (4)
1. effervescent Chinese medicinal composition with dampness removing and diarrhea-relieving function, it is characterized in that: the component of this effervescent Chinese medicinal composition and percentage by weight thereof are:
Rhizoma Coptidis 5-30%; Cortex Phellodendri 5-30%;
Radix Et Rhizoma Rhei 10-30%; Radix Scutellariae 5-30%;
Radix Isatidis 10-30%; Radix Glycyrrhizae 5-30%;
Effervescent 10-30%; Lubricant 5-20%.
2. the effervescent Chinese medicinal composition with dampness removing and diarrhea-relieving function according to claim 1 is characterized in that: described effervescent is combined by weight 1: 1 by the wherein a kind of and sodium bicarbonate in tartaric acid, citric acid, the adipic acid.
3. the effervescent Chinese medicinal composition with dampness removing and diarrhea-relieving function according to claim 1 is characterized in that: described lubricant is wherein a kind of in sucralose, erythritol, magnesium stearate, the dodecyl sodium sulfate.
4. preparation method with effervescent Chinese medicinal composition of dampness removing and diarrhea-relieving function as claimed in claim 1, it is characterized in that: the step of this preparation method is:
(1) taking by weighing Rhizoma Coptidis, Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Radix Isatidis, Radix Glycyrrhizae according to weight proportion decocts with water twice, two hours for the first time, one hour for the second time, collecting decoction, filter, it is 1.32～1.35 thick paste that filtrate is concentrated into relative density, drying, pulverize the back all by 80 mesh sieves, obtain mixture A;
(2) take by weighing effervescent, lubricant according to weight proportion and pulverize the back respectively, obtain mixture B all by the abundant mix homogeneously of mixture A in 80 mesh sieves and the step (1);
(3) be binding agent system soft material with mixture B with concentration 50～60% alcoholic solution of 2～4%PVP, and with soft material all by 10～15 mesh sieve system granules, under 50～60 ℃, carry out aeration-drying, all make granulate again, promptly obtain the effervescent Chinese medicinal composition that finished product has dampness removing and diarrhea-relieving function by 20～30 mesh sieves.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101947270A (en) * | 2010-10-14 | 2011-01-19 | 郑州后羿制药有限公司 | Aerosol for preventing and controlling pullorum disease and preparation method thereof |
| CN107412425A (en) * | 2017-08-09 | 2017-12-01 | 福建中农牧生物药业有限公司 | A kind of plant additive for preventing and treating transmissible gastroenteritis of swine and preparation method thereof |
| CN110812407A (en) * | 2019-11-22 | 2020-02-21 | 佛山市正典生物技术有限公司 | Sihuang dysentery stopping micro-capsule and preparation method thereof |
-
2009
- 2009-11-16 CN CN200910228403A patent/CN101816724A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101947270A (en) * | 2010-10-14 | 2011-01-19 | 郑州后羿制药有限公司 | Aerosol for preventing and controlling pullorum disease and preparation method thereof |
| CN107412425A (en) * | 2017-08-09 | 2017-12-01 | 福建中农牧生物药业有限公司 | A kind of plant additive for preventing and treating transmissible gastroenteritis of swine and preparation method thereof |
| CN110812407A (en) * | 2019-11-22 | 2020-02-21 | 佛山市正典生物技术有限公司 | Sihuang dysentery stopping micro-capsule and preparation method thereof |
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Open date: 20100901 |