CN104257827A - Effervescent granule for treating diarrhea of livestock and poultry and preparation method thereof - Google Patents
Effervescent granule for treating diarrhea of livestock and poultry and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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Abstract
The invention belongs to an effervescent granule for treating diarrhea of livestock and poultry and a preparation method thereof. The effervescent granule is prepared from the following raw materials in parts by weight: 10-40 parts of coptis chinensis, 10-40 parts of scutellaria baicalensis, 10-40 parts of cortex phellodendri, 10-40 parts of rheum officinale, 2-10 parts of a stabilizer, 2-10 parts of a binding agent, 1-5 parts of a corrigent and 5-30 parts of an effervescing agent. By introducing an effervescing technology to traditional Chinese medicinal granules, the preparation method disclosed by the invention omits a process of extracting traditional Chinese medicines and saves manpower and material resources; the granule disclosed by the invention is convenient to use and only needs to be put into water, thus simplifying operation; the effervescent granule is a pure traditional Chinese medicinal preparation, has no toxic or side effect on animals and does not affect human health; original bitterness of medicines is covered, thus animals can take the effervescent granule smoothly and diseases can be cured favorably.
Description
Technical field
The present invention is technical field of animal remedy preparation, is specifically related to a kind of effervescent granule for the treatment of livestock and poultry diarrhea and preparation method thereof.
Background technology
Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri and Radix Et Rhizoma Rhei, have heat clearing and damp drying, sterilize antitoxin effect, can be used for the control of viral, bacillary, the damp and hot row diarrhoea such as HUANGBAI(sic) dysentery, epidemic diarrhea of piglet.Traditional four yellow Zhili granule preparation methoies need to make granule again by after Chinese medicine extraction, and effective ingredient can not extract by leaching process completely, are a kind of wastes to raw material, and extraction and concentration process length consuming time, efficiency is low.
The difference of effervescent and ordinary preparation is that it contains gas-producing disintegrant, effervescent is a kind of mixture of organic bronsted lowry acids and bases bronsted lowry, acid-base neutralization reaction can be there is when running into water, produce a large amount of bubble, make the rapid disintegrate of medicine and thawing, bubble adds medicine and contacts with the direct of diseased region, can play its therapeutical effect better, the carbon dioxide produced during medicine disintegration is partially dissolved in water, makes medicinal liquid have flavored action to a certain degree.
Summary of the invention
The object of this invention is to provide that a kind of preparation method is simple, effect effervescent granule for the treatment of livestock and poultry diarrhea and preparation method thereof preferably.
For achieving the above object, the technical solution used in the present invention is, treat an effervescent granule for livestock and poultry diarrhea, be made up of the raw material of following portions by weight: Rhizoma Coptidis 10 ~ 40 parts, Radix Scutellariae 10 ~ 40 parts, Cortex Phellodendri 10 ~ 40 parts, Radix Et Rhizoma Rhei 10 ~ 40 parts, stabilizing agent 2 ~ 10 parts, binding agent 2 ~ 10 parts, correctives 1 ~ 5 part, effervescent 5 ~ 30 parts.
Described stabilizing agent is any one or several in poloxamer, sodium alginate, xanthan gum, gelatin, agar, hydroxypropyl cellulose.
Described binding agent is any one or several in sodium carboxymethyl cellulose, polyvidone, Polyethylene Glycol, sucrose.
Described correctives is any one in saccharin sodium, vanillin, aspartame, stevioside.
Described effervescent is that organic acid and sodium bicarbonate combine, and the mass ratio of organic acid and sodium bicarbonate is 1:1; Described organic acid is any one in tartaric acid, citric acid, adipic acid.
The preparation method of the effervescent granule of described treatment livestock and poultry diarrhea, comprises the following steps: (1) obtained Chinese medicine powder by pulverizing 200 mesh sieves after Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei mixing, and stabilizing agent, binding agent, correctives cross 200 mesh sieves respectively, for subsequent use; (2) get the Chinese medicine powder of half, correctives, binding agent, stabilizing agent, after mixing with the organic acid in effervescent, with the ethanol of 30% ~ 70% (volume fraction) for wetting agent, in fluid bed, make granule A; (3) get remaining half Chinese medicine powder, correctives, binding agent and stabilizing agent, after mixing with sodium bicarbonate, with the ethanol of 30% ~ 70% (volume fraction) for wetting agent, in fluid bed, make granule B; (4) by A, B two kinds of granule mix homogeneously, the effervescent granule of livestock and poultry diarrhea must be treated.
The beneficial effect that the present invention produces is incorporated into by effervescent technique in Chinese medicine granules, avoids the link of Chinese medicine extraction, save manpower and materials; Granule of the present invention is easy to use, only need drop in water, simplify operation; Effervescent granule of the present invention is pure Chinese medicinal preparation, can not produce toxic and side effects to animal, also can not have an impact to health; Mask the original bitterness of medicine, be beneficial to animal and drink, be conducive to the rehabilitation of disease.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but protection scope of the present invention is not limited thereto.
Embodiment 1
Treat an effervescent granule for livestock and poultry diarrhea, be made up of the raw material of following portions by weight: Rhizoma Coptidis 10 parts, Radix Scutellariae 10 parts, Cortex Phellodendri 38 parts, Radix Et Rhizoma Rhei 20 parts, poloxamer (poloxamer F68) 5 parts, sodium carboxymethyl cellulose 5 parts, saccharin sodium 2 parts, 5 parts, tartaric acid, sodium bicarbonate 5 parts.
The preparation process of the effervescent granule of described treatment livestock and poultry diarrhea is as follows: (1) obtained Chinese medicine powder by pulverizing 200 mesh sieves after Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei mixing, poloxamer, sodium carboxymethyl cellulose, saccharin sodium cross 200 mesh sieves respectively, for subsequent use; (2) get the Chinese medicine powder of half, saccharin sodium, poloxamer, sodium carboxymethyl cellulose, after mixing with tartaric acid, with the ethanol of 30% (volume fraction) for wetting agent, in fluid bed, make granule A; (3) get remaining half Chinese medicine powder, saccharin sodium, sodium carboxymethyl cellulose and poloxamer, after mixing with sodium bicarbonate, with the ethanol of 30% (volume fraction) for wetting agent, in fluid bed, make granule B; (4) by A, B two kinds of granule mix homogeneously, the effervescent granule of livestock and poultry diarrhea must be treated.
Embodiment 2
Treat an effervescent granule for livestock and poultry diarrhea, be made up of the raw material of following portions by weight: Rhizoma Coptidis 20 parts, Radix Scutellariae 10 parts, Cortex Phellodendri 20 parts, Radix Et Rhizoma Rhei 10 parts, sodium alginate 2 parts, polyvidone (polyvidone k30) 3 parts, vanillin 5 parts, citric acid 2.5 parts, sodium bicarbonate 2.5 parts.
The preparation method of the effervescent granule of described treatment livestock and poultry diarrhea, comprise the following steps: (1) obtained Chinese medicine powder by pulverizing 200 mesh sieves after Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei mixing, sodium alginate, polyvidone, vanillin cross 200 mesh sieves respectively, for subsequent use; (2) get the Chinese medicine powder of half, vanillin, sodium alginate, polyvidone, after mixing with citric acid, with the ethanol of 70% (volume fraction) for wetting agent, in fluid bed, make granule A; (3) get remaining half Chinese medicine powder, vanillin, polyvidone and sodium alginate, after mixing with sodium bicarbonate, with the ethanol of 70% (volume fraction) for wetting agent, in fluid bed, make granule B; (4) by A, B two kinds of granule mix homogeneously, the effervescent granule of livestock and poultry diarrhea must be treated.
Embodiment 3
Treat an effervescent granule for livestock and poultry diarrhea, be made up of the raw material of following portions by weight: Rhizoma Coptidis 20 parts, Radix Scutellariae 20 parts, Cortex Phellodendri 20 parts, Radix Et Rhizoma Rhei 10 parts, xanthan gum 10 parts, Polyethylene Glycol (polyethylene glycol 6000) 3 parts, aspartame 2 parts, adipic acid 11 parts, sodium bicarbonate 11 parts.
The preparation method of the effervescent granule of described treatment livestock and poultry diarrhea, comprise the following steps: (1) obtained Chinese medicine powder by pulverizing 200 mesh sieves after Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei mixing, xanthan gum, Polyethylene Glycol, aspartame cross 200 mesh sieves respectively, for subsequent use; (2) get the Chinese medicine powder of half, aspartame, xanthan gum, Polyethylene Glycol, after mixing with adipic acid, with the ethanol of 50% (volume fraction) for wetting agent, in fluid bed, make granule A; (3) get remaining half Chinese medicine powder, aspartame, Polyethylene Glycol and xanthan gum, after mixing with sodium bicarbonate, with the ethanol of 50% (volume fraction) for wetting agent, in fluid bed, make granule B; (4) by A, B two kinds of granule mix homogeneously, the effervescent granule of livestock and poultry diarrhea must be treated.
Embodiment 4
Treat an effervescent granule for livestock and poultry diarrhea, be made up of the raw material of following portions by weight: Rhizoma Coptidis 30 parts, Radix Scutellariae 10 parts, Cortex Phellodendri 10 parts, Radix Et Rhizoma Rhei 10 parts, 5 parts, gelatin, sucrose 10 parts, stevioside 5 parts, citric acid 10 parts, sodium bicarbonate 10 parts.
The preparation method of the effervescent granule of described treatment livestock and poultry diarrhea, comprises the following steps: (1) obtained Chinese medicine powder by pulverizing 200 mesh sieves after Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei mixing, and gelatin, sucrose, stevioside cross 200 mesh sieves respectively, for subsequent use; (2) get the Chinese medicine powder of half, stevioside, gelatin, sucrose, after mixing with the citric acid in effervescent, with the ethanol of 40% (volume fraction) for wetting agent, in fluid bed, make granule A; (3) get remaining half Chinese medicine powder, stevioside, sucrose and gelatin, after mixing with sodium bicarbonate, with the ethanol of 40% (volume fraction) for wetting agent, in fluid bed, make granule B; (4) by A, B two kinds of granule mix homogeneously, the effervescent granule of livestock and poultry diarrhea must be treated.
Embodiment 5
Treat an effervescent granule for livestock and poultry diarrhea, be made up of the raw material of following portions by weight: Rhizoma Coptidis 20 parts, Radix Scutellariae 40 parts, Cortex Phellodendri 40 parts, Radix Et Rhizoma Rhei 40 parts, 5 parts, agar, sodium carboxymethyl cellulose 2 parts, saccharin sodium 2 parts, 5 parts, tartaric acid, sodium bicarbonate 5 parts.
The preparation process of the effervescent granule of described treatment livestock and poultry diarrhea is as follows: (1) obtained Chinese medicine powder by pulverizing 200 mesh sieves after Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei mixing, and agar, sodium carboxymethyl cellulose, saccharin sodium cross 200 mesh sieves respectively, for subsequent use; (2) get the Chinese medicine powder of half, saccharin sodium, agar, sodium carboxymethyl cellulose, after mixing with tartaric acid, with the ethanol of 30% (volume fraction) for wetting agent, in fluid bed, make granule A; (3) get remaining half Chinese medicine powder, saccharin sodium, sodium carboxymethyl cellulose and agar, after mixing with sodium bicarbonate, with the ethanol of 60% (volume fraction) for wetting agent, in fluid bed, make granule B; (4) by A, B two kinds of granule mix homogeneously, the effervescent granule of livestock and poultry diarrhea must be treated.
Embodiment 6
Treat an effervescent granule for livestock and poultry diarrhea, be made up of the raw material of following portions by weight: Rhizoma Coptidis 40 parts, Radix Scutellariae 10 parts, Cortex Phellodendri 20 parts, Radix Et Rhizoma Rhei 10 parts, hydroxypropyl cellulose 2 parts, polyvidone k303 part, vanillin 1 part, citric acid 15 parts, sodium bicarbonate 15 parts.
The preparation method of the effervescent granule of described treatment livestock and poultry diarrhea, comprise the following steps: (1) obtained Chinese medicine powder by pulverizing 200 mesh sieves after Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei mixing, hydroxypropyl cellulose, polyvidone, vanillin cross 200 mesh sieves respectively, for subsequent use; (2) get the Chinese medicine powder of half, vanillin, hydroxypropyl cellulose, polyvidone, after mixing with citric acid, with the ethanol of 70% (volume fraction) for wetting agent, in fluid bed, make granule A; (3) get remaining half Chinese medicine powder, vanillin, polyvidone and hydroxypropyl cellulose, after mixing with sodium bicarbonate, with the ethanol of 70% (volume fraction) for wetting agent, in fluid bed, make granule B; (4) by A, B two kinds of granule mix homogeneously, the effervescent granule of livestock and poultry diarrhea must be treated.
Application test
Prevention group: select the piglet 200 (10 ~ 15 age in days) do not fallen ill, be divided into 2 groups at random, often organize 100, matched group adopts common four yellow Zhili granules to prevent, the product prevention that experimental group adopts the embodiment of the present invention 1 to prepare, using method is the administration of mixed drink, and the preventive dose of the medicine of experimental group and matched group is 1g/L drinking-water, be used in conjunction 7 days, prophylactic tria result is see table 1:
Table 1. prophylactic tria result
| Group | Piglet number (head) | Morbidity (head) | Healthy (head) | Protective rate (%) |
| Experimental group | 100 | 7 | 93 | 93 |
| Matched group | 100 | 8 | 92 | 92 |
Treatment group: select the broiler 200 (2 ~ 3 age in days) having Hakuri symptom, be divided into 2 groups at random, matched group adopts common four yellow Zhili granules to treat, the product treatment that experimental group adopts the embodiment of the present invention 1 to prepare, using method is the administration of mixed drink, the preventive dose of the medicine of experimental group and matched group is 2g/L drinking-water, and be used in conjunction 7 days, therapeutic test result is see table 2:
Table 2. therapeutic test result
Result of the test
Prophylactic tria criterion is as follows:
Morbidity: piglet diarrhea, row's yellow or white water sample loose stool, depressed, the loss of appetite of spirit; Healthy: piglet does not show any exception.Protective rate=healthy pig's head number/total head number × 100%.
Therapeutic test criterion is as follows:
Cure: chick feces character and color, spirit, appetite all recover normal, effectively: the feces retrogradation of chick, spirit takes a turn for the better, and appetite increases.Invalid: the cardinal symptom of chick is without any improvement, even increases the weight of.Cure rate=healing number of elements/total number of elements × 100%.
Through morbidity and the rehabilitation situation of observed and recorded piglet and chick, obtain a result, the laboratory animal incidence basic simlarity of prevention group, two kinds of granules all have good preventive effect to piglet diarrhea; In therapeutic test, experimental group therapeutic effect is obvious, and the product treatment chick diarrhoea cure rate adopting the embodiment of the present invention 1 to prepare is 94%, exceeds 12%, significant difference than common four yellow Zhili granules.
Claims (6)
1. treat the effervescent granule of livestock and poultry diarrhea for one kind, it is characterized in that, be made up of the raw material of following portions by weight: Rhizoma Coptidis 10 ~ 40 parts, Radix Scutellariae 10 ~ 40 parts, Cortex Phellodendri 10 ~ 40 parts, Radix Et Rhizoma Rhei 10 ~ 40 parts, stabilizing agent 2 ~ 10 parts, binding agent 2 ~ 10 parts, correctives 1 ~ 5 part, effervescent 5 ~ 30 parts.
2. the effervescent granule for the treatment of livestock and poultry diarrhea as claimed in claim 1, is characterized in that: described stabilizing agent is any one or several in poloxamer, sodium alginate, xanthan gum, gelatin, agar, hydroxypropyl cellulose.
3. the effervescent granule for the treatment of livestock and poultry diarrhea as claimed in claim 1, is characterized in that: described binding agent is any one or several in sodium carboxymethyl cellulose, polyvidone, Polyethylene Glycol, sucrose.
4. the effervescent granule for the treatment of livestock and poultry diarrhea as claimed in claim 1, is characterized in that: described correctives is any one or several in saccharin sodium, vanillin, aspartame, stevioside.
5. the effervescent granule for the treatment of livestock and poultry diarrhea as claimed in claim 1, it is characterized in that: described effervescent is that organic acid and sodium bicarbonate combine, the mass ratio of organic acid and sodium bicarbonate is 1:1; Described organic acid is any one in tartaric acid, citric acid, adipic acid.
6. as described in claim 1-5, any one treats the preparation method of the effervescent granule of livestock and poultry diarrhea, it is characterized in that, comprise the following steps: (1) will Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, pulverize and sieve obtained Chinese medicine powder after Radix Et Rhizoma Rhei mixing, stabilizing agent, binding agent, correctives sieve for subsequent use respectively; (2) get the Chinese medicine powder of half, correctives, binding agent, stabilizing agent, after mixing with the organic acid in effervescent, the ethanol with 30% ~ 70% is wetting agent, makes granule A in fluid bed; (3) get remaining half Chinese medicine powder, correctives, binding agent and stabilizing agent, after mixing with sodium bicarbonate, the ethanol with 30% ~ 70% is wetting agent, makes granule B in fluid bed; (4) by A, B two kinds of granule mix homogeneously, the effervescent granule of livestock and poultry diarrhea must be treated.
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| CN201410495875.3A CN104257827A (en) | 2014-09-24 | 2014-09-24 | Effervescent granule for treating diarrhea of livestock and poultry and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535018A (en) * | 2015-12-28 | 2016-05-04 | 海南葫芦娃制药有限公司 | Calcium carbonate D3 granules and preparation method thereof |
| CN109999117A (en) * | 2019-05-24 | 2019-07-12 | 湖南泰谷生物兽药有限公司 | Prevent and treat enteritis, bacillary dysentery, dysentery, intractable diarrhea Chinese medicine composition |
| CN110954645A (en) * | 2019-09-09 | 2020-04-03 | 山东琪康生物技术有限公司 | Detection method of high-quality Sihuang dysentery stopping granules |
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| CN1895422A (en) * | 2006-06-27 | 2007-01-17 | 天津生机集团有限公司 | Chinese animal medicinal composition for treating fowl colibacillus and its making method |
| CN101987089A (en) * | 2010-11-10 | 2011-03-23 | 天大药业（珠海）有限公司 | Effervescent medicinal preparation |
| CN102008585A (en) * | 2009-09-08 | 2011-04-13 | 河南惠通天下动物药业有限公司 | Sihuang anti-dysentery effervescent particle and preparation method thereof |
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2014
- 2014-09-24 CN CN201410495875.3A patent/CN104257827A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1895422A (en) * | 2006-06-27 | 2007-01-17 | 天津生机集团有限公司 | Chinese animal medicinal composition for treating fowl colibacillus and its making method |
| CN102008585A (en) * | 2009-09-08 | 2011-04-13 | 河南惠通天下动物药业有限公司 | Sihuang anti-dysentery effervescent particle and preparation method thereof |
| CN101987089A (en) * | 2010-11-10 | 2011-03-23 | 天大药业（珠海）有限公司 | Effervescent medicinal preparation |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535018A (en) * | 2015-12-28 | 2016-05-04 | 海南葫芦娃制药有限公司 | Calcium carbonate D3 granules and preparation method thereof |
| CN105535018B (en) * | 2015-12-28 | 2018-06-19 | 海南葫芦娃药业集团股份有限公司 | A kind of calcium carbonate D3 particles and preparation method thereof |
| CN109999117A (en) * | 2019-05-24 | 2019-07-12 | 湖南泰谷生物兽药有限公司 | Prevent and treat enteritis, bacillary dysentery, dysentery, intractable diarrhea Chinese medicine composition |
| CN110954645A (en) * | 2019-09-09 | 2020-04-03 | 山东琪康生物技术有限公司 | Detection method of high-quality Sihuang dysentery stopping granules |
| CN110954645B (en) * | 2019-09-09 | 2020-09-29 | 山东琪康生物技术有限公司 | Detection method of high-quality Sihuang dysentery stopping granules |
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Application publication date: 20150107 |
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| RJ01 | Rejection of invention patent application after publication |