CN103202909A - Traditional Chinese medicine feed additive for preventing and curing diarrhea of livestock and poultry as well as fur-bearing animals - Google Patents
Traditional Chinese medicine feed additive for preventing and curing diarrhea of livestock and poultry as well as fur-bearing animals Download PDFInfo
- Publication number
- CN103202909A CN103202909A CN2013101114005A CN201310111400A CN103202909A CN 103202909 A CN103202909 A CN 103202909A CN 2013101114005 A CN2013101114005 A CN 2013101114005A CN 201310111400 A CN201310111400 A CN 201310111400A CN 103202909 A CN103202909 A CN 103202909A
- Authority
- CN
- China
- Prior art keywords
- traditional chinese
- chinese medicine
- parts
- poultry
- fur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010012735 Diarrhoea Diseases 0.000 title claims abstract description 51
- 241001465754 Metazoa Species 0.000 title claims abstract description 24
- 244000144977 poultry Species 0.000 title claims abstract description 18
- 239000003674 animal food additive Substances 0.000 title claims abstract description 12
- 239000003814 drug Substances 0.000 title abstract description 39
- 244000144972 livestock Species 0.000 title abstract description 5
- 241000628997 Flos Species 0.000 claims description 9
- 239000009636 Huang Qi Substances 0.000 claims description 9
- 241000196133 Dryopteris Species 0.000 claims description 6
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 6
- 241000411851 herbal medicine Species 0.000 claims description 4
- 235000013305 food Nutrition 0.000 abstract description 4
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- 239000008267 milk Substances 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 235000013336 milk Nutrition 0.000 abstract description 2
- 210000004080 milk Anatomy 0.000 abstract description 2
- 241000045403 Astragalus propinquus Species 0.000 abstract 1
- 240000005250 Chrysanthemum indicum Species 0.000 abstract 1
- 235000018959 Chrysanthemum indicum Nutrition 0.000 abstract 1
- 241000037740 Coptis chinensis Species 0.000 abstract 1
- 241000218691 Cupressaceae Species 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 23
- 208000024891 symptom Diseases 0.000 description 15
- 241000287828 Gallus gallus Species 0.000 description 14
- 235000013594 poultry meat Nutrition 0.000 description 13
- 239000000654 additive Substances 0.000 description 12
- 230000000996 additive effect Effects 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 241000282898 Sus scrofa Species 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 235000013330 chicken meat Nutrition 0.000 description 10
- 239000000843 powder Substances 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 210000003608 fece Anatomy 0.000 description 7
- 235000013599 spices Nutrition 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000010298 pulverizing process Methods 0.000 description 6
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 5
- 230000036285 pathological change Effects 0.000 description 5
- 231100000915 pathological change Toxicity 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 230000003115 biocidal effect Effects 0.000 description 4
- 239000003651 drinking water Substances 0.000 description 4
- 235000020188 drinking water Nutrition 0.000 description 4
- 239000003640 drug residue Substances 0.000 description 4
- 238000003304 gavage Methods 0.000 description 4
- 230000036039 immunity Effects 0.000 description 4
- 238000011081 inoculation Methods 0.000 description 4
- 230000000968 intestinal effect Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 241000271566 Aves Species 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 241000282836 Camelus dromedarius Species 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 241001508687 Mustela erminea Species 0.000 description 3
- 241001482564 Nyctereutes procyonoides Species 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 241001494479 Pecora Species 0.000 description 3
- 241000282485 Vulpes vulpes Species 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 210000004347 intestinal mucosa Anatomy 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000009413 Chuanxinlian Substances 0.000 description 2
- 241000283073 Equus caballus Species 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- 206010020565 Hyperaemia Diseases 0.000 description 2
- 241001262617 Japonica Species 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 210000000436 anus Anatomy 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 238000003771 laboratory diagnosis Methods 0.000 description 2
- 210000003097 mucus Anatomy 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 235000011837 pasties Nutrition 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 201000009032 substance abuse Diseases 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 239000000273 veterinary drug Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 description 1
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 description 1
- CUJMCPPBTUATEJ-UHFFFAOYSA-N 1-(3-methyl-4-oxido-1-oxoquinoxalin-1-ium-2-yl)ethanone Chemical compound C1=CC=C2[N+](=O)C(C(=O)C)=C(C)N([O-])C2=C1 CUJMCPPBTUATEJ-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 241000272814 Anser sp. Species 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000252983 Caecum Species 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000018672 Dilatation Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010021639 Incontinence Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- KJHOZAZQWVKILO-UHFFFAOYSA-N N-(diaminomethylidene)-4-morpholinecarboximidamide Chemical compound NC(N)=NC(=N)N1CCOCC1 KJHOZAZQWVKILO-UHFFFAOYSA-N 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 229960004150 aciclovir Drugs 0.000 description 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 description 1
- 229960003805 amantadine Drugs 0.000 description 1
- 229940126575 aminoglycoside Drugs 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 210000004534 cecum Anatomy 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 210000003555 cloaca Anatomy 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- -1 compound sulfonamide Chemical class 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- DNJIEGIFACGWOD-UHFFFAOYSA-N ethanethiol Chemical compound CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 229960003760 florfenicol Drugs 0.000 description 1
- 229940124307 fluoroquinolone Drugs 0.000 description 1
- 239000004459 forage Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 210000000713 mesentery Anatomy 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229960005389 moroxydine Drugs 0.000 description 1
- 229940113083 morpholine Drugs 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000036473 myasthenia Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 235000013613 poultry product Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229960000329 ribavirin Drugs 0.000 description 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 1
- 229960000888 rimantadine Drugs 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 210000001113 umbilicus Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000003911 water pollution Methods 0.000 description 1
Abstract
The invention discloses a traditional Chinese medicine feed additive for preventing and curing diarrhea of livestock and poultry as well as fur-bearing animals, which belongs to the technical field of traditional Chinese medicine feed additives. The traditional Chinese medicine feed additive mainly comprises the following traditional Chinese medicines in parts by weight: 10-20 parts of coptis chinensis, 15-25 parts of golden cypress, 10-20 parts of moutan bark, 15-20 parts of root of common peony, 10-20 parts of mother chrysanthemum and 10-15 parts of astragalus mongholicus. The traditional Chinese medicine feed additive not only can prevent diarrhea of livestock and poultry, but also has an obvious therapeutic effect, is similarly effective to fur-bearing animals, is a pure traditional Chinese medicine, can effectively prevent problems of milk resistance, medicament residues and poor food safety, and is suitable for being popularized in animal production.
Description
Technical field
The invention belongs to the veterinary drug technical field, particularly a kind of Chinese herbal feed additive of preventing and treating poultry and fur-bearing animal diarrhoea.
Background technology
Along with China's living standard of urban and rural population level improves constantly, and the raising of people's environmental consciousness and food safety consciousness, the livestock and poultry product prescription is improved constantly, food-safety problem is required increasingly stringent.As require product safety, green, drug residue free, nuisanceless etc., and drug residue is to influence meat, egg, milk waits the key factor of animal products safety, and human body is often taken in the left drugs such as antibiotic of low dosage, can accumulate in vivo gradually and cause various organ generation pathological changes, produce allergy, anaphylaxis, immunosuppressant etc., final harm humans health, especially nearest 2012 CCTV1, events such as numerous medium unit exposure speed live chickens such as CCTV13 and Focus and false veterinary drug cause great disturbance in the industry, the problem of food safety is white-hot day by day, and the development that will continue for China's animal husbandry science causes and has a strong impact on.
The problem of drug residue has restricted the development of industry, and the problem of livestock and poultry diarrhea has been brought enormous economic loss to aquaculture, has become the important difficult problem of the intensive animal husbandry development of serious threat.Cause that as everyone knows the reason of diarrhoea is numerous as (as viral infection, bacterial infection, water pollution, feed mold, environmental factors, numerous factors such as temperature great change), add along with the breed scale constantly enlarges, breeding environment worsens day by day, disease is multiple, the death rate height, measures such as abuse of antibiotics and antiviral chemical medicine cause cause of disease that these medicines are produced serious Drug resistance, therapeutic effect is not remarkable day by day, increase the weight of the difficulty of antibiotic research and development, the antimicrobial drug for the treatment of diarrhoea at present has kind more than 200, but because life-time service, the pig avian escherichia coli, the resistant rate of Salmonella etc. is very high, its curative effect significantly descends even is invalid, and fastbacteria is the trend of multidrug resistant and crossing drug resistant, be that fastbacteria is to penicillins, cephalosporins, fluoroquinolones, aminoglycoside, florfenicol, the compound sulfonamide medicine also is drug resistance, add clinical in a large amount of abuses of antibiotics, even use human drugs, cause the drug resistance problem serious day by day, therapeutic effect is not remarkable day by day, increase the weight of the difficulty of antibiotic research and development, meanwhile be used for the treatment of virus and cause that the chemicals of diarrhoea was as far back as U.S. FDA in 2006, amantadine is forbidden in the dispatch of China Ministry of Agriculture, rimantadine, acyclovir, morpholine (two) guanidine (moroxydine), chemical antiviral agents such as ribavirin, cause the medicine of control diarrhoea blank to occur, therefore demand developing a kind of safety urgently, the Chinese herbal feed additive of control diarrhoea reliably is to satisfy the demand of actual production.
Summary of the invention
The object of the present invention is to provide a kind of Chinese herbal medicine additive of preventing and treating poultry and fur-bearing animal diarrhoea.
For solving the problems of the technologies described above, the technical scheme that the present invention takes is:
The Chinese herbal feed additive of control poultry and fur-bearing animal diarrhoea mainly is made up of following weight portion Chinese crude drug: Rhizoma Coptidis 10-20 part, Cortex Phellodendri 15-25 part, Cortex Moutan 10-20 part, Radix Paeoniae Rubra 15-20 part, Flos Chrysanthemi Indici 10-20 part, Radix Astragali 10-15 part.
Further, in weight portion, also comprise: Radix Scutellariae 10-15 part, Spica Prunellae 15-20 part, Rhizoma Dryopteris Crassirhizomatis 10-15 part, Herba Lophatheri 10-15 part, Herba Houttuyniae 10-20 part.
Diarrhoea is full of three warmers, internal organs excess-heat or damp and hot disease from the dialectical genus pathogenic heat of Chinese veterinarian's angle.So in the side with the clear eliminating heart-fire of Rhizoma Coptidis, hold concurrently clear in Jiao's fire, the fire that Cortex Phellodendri is rushed down part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels Liver and kidney is principal agent, just in Flos Chrysanthemi Indici, Radix Scutellariae, Spica Prunellae, Rhizoma Dryopteris Crassirhizomatis, Herba Lophatheri, Herba Houttuyniae heat-clearing and toxic substances removing be accessory drugs.The Radix Paeoniae Rubra clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, the dysmenorrhea analgesia, the Cortex Moutan acrid in the mouth is cold in nature, the function clearing away heat and cooling blood, controlling the blood dissipating blood stasis is adjuvant drug, Radix Astragali QI invigorating is set upright, granulation promoting, the detoxifcation of holder skin ulcer is for making medicine.All medicines share, and play the effect of clearing away heat-fire, detoxifcation, antibiotic, antiinflammatory altogether.
This Chinese herbal medicine additive not only can prevent poultry and fur-bearing animal diarrhoea, and therapeutic effect is remarkable according to the dialectical theory of Chinese veterinarian.As preventing diseases such as animal diarrhoea such as chicken, duck, goose, Carnis Coturnicis japonicae, cattle, sheep, donkey, camel, fox, Nyctereutes procyonoides, ermine, rabbit that curative effect is preferably all arranged, total effective rate is more than 96%.When being used for the treatment of, total effective rate is more than 97%.
Chinese herbal feed additive of the present invention is regulated the diarrhoea that using dosage could prevent or treat poultry and fur-bearing animal significantly, and during as prevention, general addition is the 0.4-0.6% of feeding quality; If treatment diarrhoea, using dosage is 0.5-1.5%.During use, after said medicine can being pulverized, cross 300 mesh sieves, what obtain is powder.Select according to practical situation during use, can adopt spice mixed feeding method as the large-scale cultivation field, raising the family scattered both can the spice mixed feeding, also powder decocting extracting juice drinking-water also can be able to be gavaged.
Chinese herbal medicine additive of the present invention is pure tcm product, can avoid anti-milk, drug residue and food-safety problem effectively, can be processed into various dosage forms (as powder, oral liquid, granule, tablet, pill, unguentum etc.) simultaneously and suit in herding is produced, to promote.
The specific embodiment
Below with specific embodiment technical scheme of the present invention is described, but protection scope of the present invention is not limited thereto:
Embodiment 1
The additive of control poultry and fleece animal diarrhoea, composed as follows:
Rhizoma Coptidis 15g, Cortex Phellodendri 20g, Cortex Moutan 15g, Radix Paeoniae Rubra 17.5g, Flos Chrysanthemi Indici 15g, Radix Astragali 12.5g.
All medicine pulverizations are crossed 300 mesh sieves, obtain powder.
Embodiment 2
The additive of control poultry and fleece animal diarrhoea, composed as follows:
Rhizoma Coptidis 10g, Cortex Phellodendri 15g, Cortex Moutan 10g, Radix Paeoniae Rubra 15g, Flos Chrysanthemi Indici 10g, Radix Astragali 10g.
All medicine pulverizations are crossed 300 mesh sieves, obtain powder.
Embodiment 3
The additive of control poultry and fleece animal diarrhoea, composed as follows:
Rhizoma Coptidis 20g, Cortex Phellodendri 25g, Cortex Moutan 20g, Radix Paeoniae Rubra 20g, Flos Chrysanthemi Indici 20g, Radix Astragali 15g.
All medicine pulverizations are crossed 300 mesh sieves, obtain powder.
Embodiment 4
The additive of control poultry and fleece animal diarrhoea, composed as follows:
Rhizoma Coptidis 15g, Cortex Phellodendri 20g, Cortex Moutan 15g, Radix Paeoniae Rubra 17.5g, Flos Chrysanthemi Indici 15g, Radix Astragali 12.5g, Radix Scutellariae 12.5g, Spica Prunellae 17.5g, Rhizoma Dryopteris Crassirhizomatis 12.5g, Herba Lophatheri 12.5g, Herba Houttuyniae 15g.
All medicine pulverizations are crossed 300 mesh sieves, obtain powder.
Embodiment 5
The additive of control poultry and fleece animal diarrhoea, composed as follows:
Rhizoma Coptidis 10g, Cortex Phellodendri 15g, Cortex Moutan 10g, Radix Paeoniae Rubra 15g, Flos Chrysanthemi Indici 10g, Radix Astragali 10g, Radix Scutellariae 10g, Spica Prunellae 15g, Rhizoma Dryopteris Crassirhizomatis 10g, Herba Lophatheri 10g, Herba Houttuyniae 10g.
All medicine pulverizations are crossed 300 mesh sieves, obtain powder.
Embodiment 6
The additive of control poultry and fleece animal diarrhoea, composed as follows:
Rhizoma Coptidis 20g, Cortex Phellodendri 25g, Cortex Moutan 20g, Radix Paeoniae Rubra 20g, Flos Chrysanthemi Indici 20g, Radix Astragali 15g, Radix Scutellariae 15g, Spica Prunellae 20g, Rhizoma Dryopteris Crassirhizomatis 15g, Herba Lophatheri 15g, Herba Houttuyniae 20g.
All medicine pulverizations are crossed 300 mesh sieves, obtain powder.
Effect:
Embodiment 1 additive spice is for oral administration: when being used for the treatment of, big domestic animal such as cattle, horse and camel: 150-300g/ head; Pig, sheep: 50-100g/ head, fox, Nyctereutes procyonoides, ermine: 15-30g/ only, rabbit: 6-12g/ only, birds: 1-3g/ only adds up curative effect after being used in conjunction 5 days.Preventive dose reduces by half.
Efficacy determination: protective rate is being considered as more than 96% effectively during prevention.During treatment, took medicine 5, symptom of diarrhea is eliminated, and not repeatedly, is considered as curing in 7 days; In 10 days, no symptom of diarrhea is considered as effectively, otherwise invalid.Effect sees table 1(prevention for details) and table 2(treatment).
Table 1
Table 2
Embodiment 4 additive spices are for oral administration: during treatment, big domestic animal such as cattle, horse and camel: 150-300g/ head; Pig, sheep: 50-100g/ head, fox, Nyctereutes procyonoides, ermine: 15-30g/ only, rabbit: 6-12g/ only, birds: 1-3g/ only or according to forage volume 0.5-1.5% spice mixed feeding, adds up curative effect after being used in conjunction 5 days.Preventive dose reduces by half.
Efficacy determination is with embodiment 1 additive.The result sees table 3(prevention for details) and table 4(treatment).
Table 3
Table 4
Concrete case 1
In June, 2010,20000 Carnis Coturnicis japonicaes of Liu of Changge City, Xuchang raising are randomly drawed 900, are divided into test group and matched group, each 450.Two groups in unified house according to routine raising, immunity inoculation, sterilization etc.
Get the Chinese medicine composition of embodiment 1 and pulverize, cross 300 mesh sieves, after test group is added feedstuff and mix homogeneously according to 0.5% ratio, free choice feeding, the interpolation time since 28 ages in days until 35 ages in days.Except natural death, matched group the dead Carnis Coturnicis japonicae of diarrhoea occurs and amounts to 43, mortality rate 9.56% during this time; Test group is because suffering from diarrhoea 11 of dead Carnis Coturnicis japonicaes, mortality rate 2.44%.
Concrete case 2
In January, 2010,12000 817 broiler of Lee of Mengzhou City raising, randomly draw 600 and be divided into test group and matched group, except according to routine raising, immunity inoculation, the sterilization etc., getting the Chinese medicine composition of embodiment 1 pulverizes, cross 300 mesh sieves, test group is made granule after adding feedstuff and mix homogeneously according to 0.6% ratio.According to Lee plant incidence in the past, diarrhoea is many to begin about 30 ages in days, and therefore test being added into 31 ages in days since 26 ages in days.Except natural death, matched group the dead chicken of diarrhoea occurs and amounts to 28, mortality rate 9.33% during this time; Test group is because suffering from diarrhoea 5 of dead chickens, mortality rate 1.67%.Continue to observe in 10 days test group and do not see symptom of diarrhea, symptom of diarrhea appears in matched group, because suffering from diarrhoea 8 of dead chickens.
Concrete case 3
In February, 2011, Xiping County Lee's pig farm extract out at random 8 nests with age in days with 92 of the piglets of pig house, 45 of test group, 47 of matched groups, duration of test test group and matched group are got the Chinese medicine composition of embodiment 2 and are pulverized except according to the raising of routine raising pattern, immunity inoculation, the sterilization etc., cross 300 mesh sieves, test group is according to the 30g/ head, makes granule after making an addition to feedstuff and mix homogeneously.Weaned preceding 4 days, and brought into use, be used in conjunction 5 days.Effective percentage 100.0% symptom of diarrhea do not appear, in 45 piglets of test group during this time; There are 5 diarrhoea, sickness rate 10.64% to occur in 47 piglets of matched group.The morbidity back is according to the 50g/ head, and the decocting extracting juice gavages, and once a day, is used in conjunction 5, and wherein 2 serious sick pigs adopt CHUANXINLIAN ZHUSHEYE and injection liquid of gentamicin to treat 3 days, recovery from illness after 5 days.Test group and matched group continue to observe 10 days after off-test, do not see symptom of diarrhea.
Concrete case 4
In November, 2009,15000 laying hens of Shangqiu Liangyuan District Lee raising are randomly drawed 1000 and are divided into test group and matched group, except according to routine raising, immunity inoculation, the sterilization etc., getting the Chinese medicine composition of embodiment 4 pulverizes, cross 300 mesh sieves, test group is added feedstuff according to 0.6% ratio, supplies the chicken free choice feeding behind the mix homogeneously, according to this laying hen occurrence regularity of suffering from diarrhoea in the past, generally during 100 age in days to 125 ages in days, suffer from diarrhoea, so test group adds since 95 ages in days, be used in conjunction 10 days.Prevention effect is observed: duration of test, and matched group chicken group is at 64 of the dead chickens of 95 to 145 age in days endogenous causes of ill diarrhoea, mortality rate 12.8%; Test group none death in 95 to 145 ages in days.
Concrete case 5
In April, 2012, the large-scale white plumage broiler of 7500 pieces of Huojia County Wang's raising is in 27 age in days skies, and it is thin in water sample feces to occur, idol has yellow, white, green feces, and undergrowth appears in serious broiler, and body is become thin, the hat whisker turns white, and falls ill after 3 days, and chicken begins to occur dead; Die of illness the hyperemia of Intestinum Gallus domesticus mucosa, hemorrhage, come off, the intestinal wall attenuation, cloaca is hemorrhage, and is interior just like watery yellow-white feces etc.300 mesh sieves and mixing are pulverized, crossed to the Chinese medicine composition of getting embodiment 5; It is to boil water to get this powder by 0.75% of material feeding amount, liquid medicine drinking-water, the medicinal residues spice, symptom disappears substantially after being used in conjunction 5 days, the state of an illness do not occur repeatedly in 7 days, and disease must heal, be total to 294 of dead chickens during the medication, mortality rate symptom of diarrhea and death did not occur in 3.92%, the 5,6,7 day, did not find in the 8th, 9,10 day that symptom of diarrhea and none example are dead.
Concrete case 6
In December, 2010,220 piglets in Runan County are suffered from diarrhoea suddenly, discharge milky or linen pulpous state, pasty state stickiness feces, it is tired to follow disease pig appearance spirit, and thick random by hair, body surface is unglazed, loss of appetite, myasthenia of limbs, walking is unstable or the ground that crouches is difficult rises, feces is the canescence stench, slack anus, the feces incontinence is become thin, is dewatered, indivedual pig extremely feebles and dead, mortality rate 5.45%.Pathological change is become thin for the pig corpse of dying of illness, and mucosa is pale, and by fecal pollution, intestinal mucosa was catarrhal inflammation around anus reached, the intestinal wall attenuation, and colonic has milky or canescence pasty state or ointment shape content, mesenteric lymph node mild swelling etc.Through clinical symptoms, pathological change and laboratory diagnosis, be diagnosed as piglet pujos blancos.
Getting the Chinese medicine composition of embodiment 6 pulverizes, cross 300 mesh sieves, test group is according to the 50g/ head, and the decocting extracting juice gavages, once a day, serve on 5, the salt of fluid infusion simultaneously drinking-water is used in conjunction 3 days, and symptom disappears substantially after 5 days, in 10 days the state of an illness does not appear repeatedly, the recovery from illness, during the medication except 1 piglet because of the serious dehydration death, do not have piglet death again.
Concrete case 7
In January, 2011, inappetence appears in the piglet that Neihuang County Lee buys about 120 60 ages in days from the other places, and spirit is depressed, vomiting and mucus diarrhoea, and between feces or blood is arranged or come to mucous membrane tissue fragment etc., case fatality rate is 8.3%.Pathological change is based on intestinal.Small intestinal mucosa and mesentery hyperemia, hemorrhage, dilatation of intestine, in be full of yellow liquid, intestinal villi shortens, weight person's Villus atrophy even disappear; Big intestinal mucosa generation Catarrhal, hemorrhagic enteritis, colon and the swelling of caecum mucosa, gauffer is obvious, upward with mucus, clot and fibrinous exudate etc.Be diagnosed as swine dysentery and epidemic diarrhea mixed infection through clinical symptoms, pathological change and laboratory diagnosis.
Getting the Chinese medicine composition of embodiment 4 pulverizes, cross 300 mesh sieves, test group is according to the 60g/ head, and the decocting extracting juice gavages, once a day, serve on 5, the medicinal residues spice, the salt of fluid infusion simultaneously drinking-water is used in conjunction 3 days, and indivedual serious piglets cooperate CHUANXINLIAN ZHUSHEYE, mequindox injection and interferon intramuscular injection, every day 1 time, be used in conjunction 3 days.Symptom of diarrhea disappears substantially after 5 days, the state of an illness do not occur repeatedly in 7 days, recovery from illness, none piglet death during the medication.
Concrete case 8
In May, 2012,96 ablactational baby pig of Yingyang Cui's raising cause diarrhoea because of the pellet of searching for food, and get the Chinese medicine composition of embodiment 1 and pulverize, and cross 300 mesh sieves, test group is according to the 50g/ head, the decocting extracting juice gavages, and 1 time on the one, serve on 3, symptom of diarrhea disappears substantially after 3 days, do not occur symptom of diarrhea in 10 days, pig grows fine, and each side is normal.
Above-described embodiment is the preferred embodiment of the present invention, but embodiments of the present invention are not restricted to the described embodiments, and the change that other any the present invention of not deviating from does all should be the substitute mode of equivalence, is included within protection scope of the present invention.
Claims (2)
1. prevent and treat the Chinese herbal feed additive of poultry and fur-bearing animal diarrhoea, it is characterized in that, mainly formed by following weight portion Chinese herbal medicine: Rhizoma Coptidis 10-20 part, Cortex Phellodendri 15-25 part, Cortex Moutan 10-20 part, Radix Paeoniae Rubra 15-20 part, Flos Chrysanthemi Indici 10-20 part, Radix Astragali 10-15 part.
2. prevent and treat the Chinese herbal feed additive of poultry and fur-bearing animal diarrhoea according to claim 1, it is characterized in that, in weight portion, also comprise: Radix Scutellariae 10-15 part, Spica Prunellae 15-20 part, Rhizoma Dryopteris Crassirhizomatis 10-15 part, Herba Lophatheri 10-15 part, Herba Houttuyniae 10-20 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310111400.5A CN103202909B (en) | 2013-04-01 | 2013-04-01 | Traditional Chinese medicine feed additive for preventing and curing diarrhea of livestock and poultry as well as fur-bearing animals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310111400.5A CN103202909B (en) | 2013-04-01 | 2013-04-01 | Traditional Chinese medicine feed additive for preventing and curing diarrhea of livestock and poultry as well as fur-bearing animals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103202909A true CN103202909A (en) | 2013-07-17 |
| CN103202909B CN103202909B (en) | 2014-12-17 |
Family
ID=48750463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310111400.5A Active CN103202909B (en) | 2013-04-01 | 2013-04-01 | Traditional Chinese medicine feed additive for preventing and curing diarrhea of livestock and poultry as well as fur-bearing animals |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103202909B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840934A (en) * | 2015-06-11 | 2015-08-19 | 鲁东大学 | Traditional Chinese medicine composition for preventing and treating piglet diarrhea and preparation method of traditional Chinese medicine composition |
| CN104970198A (en) * | 2015-06-29 | 2015-10-14 | 何以安 | Feed additive for preventing and treating diarrhoea of cows |
| CN105010826A (en) * | 2015-06-29 | 2015-11-04 | 何以安 | Lamb diarrhea preventing and curing feed additive |
| CN105879003A (en) * | 2014-11-24 | 2016-08-24 | 李雷 | Traditional Chinese medicinal composition for treating lamb diarrhea |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101926411A (en) * | 2010-09-14 | 2010-12-29 | 丽水市林业科学研究院 | Heartleaf houttuynia herb livestock and poultry feed additive and preparation method thereof |
| CN102038082A (en) * | 2010-09-02 | 2011-05-04 | 吴艳霞 | Traditional Chinese medicinal feed additive for treating dysentery and diarrhea of livestock and poultry |
| CN102232467A (en) * | 2011-04-15 | 2011-11-09 | 北京康华远景科技有限公司 | Livestock and poultry anti-diarrheal feed additive and preparation method thereof |
| CN102379962A (en) * | 2010-09-03 | 2012-03-21 | 山东绿源新食品有限公司 | Traditional Chinese medicine combination for healthcare and treatment of livestock |
| CN102429967A (en) * | 2011-12-29 | 2012-05-02 | 甘肃农业大学 | Traditional Chinese medicine composition for preventing and treating bacterial diarrhea of livestock and poultry and application thereof |
| CN102640864A (en) * | 2012-02-23 | 2012-08-22 | 上海交通大学 | Chinese medicinal herb feed additive for improving immunity of chickens and preventing diarrhea and using method for additive |
-
2013
- 2013-04-01 CN CN201310111400.5A patent/CN103202909B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038082A (en) * | 2010-09-02 | 2011-05-04 | 吴艳霞 | Traditional Chinese medicinal feed additive for treating dysentery and diarrhea of livestock and poultry |
| CN102379962A (en) * | 2010-09-03 | 2012-03-21 | 山东绿源新食品有限公司 | Traditional Chinese medicine combination for healthcare and treatment of livestock |
| CN101926411A (en) * | 2010-09-14 | 2010-12-29 | 丽水市林业科学研究院 | Heartleaf houttuynia herb livestock and poultry feed additive and preparation method thereof |
| CN102232467A (en) * | 2011-04-15 | 2011-11-09 | 北京康华远景科技有限公司 | Livestock and poultry anti-diarrheal feed additive and preparation method thereof |
| CN102429967A (en) * | 2011-12-29 | 2012-05-02 | 甘肃农业大学 | Traditional Chinese medicine composition for preventing and treating bacterial diarrhea of livestock and poultry and application thereof |
| CN102640864A (en) * | 2012-02-23 | 2012-08-22 | 上海交通大学 | Chinese medicinal herb feed additive for improving immunity of chickens and preventing diarrhea and using method for additive |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105879003A (en) * | 2014-11-24 | 2016-08-24 | 李雷 | Traditional Chinese medicinal composition for treating lamb diarrhea |
| CN104840934A (en) * | 2015-06-11 | 2015-08-19 | 鲁东大学 | Traditional Chinese medicine composition for preventing and treating piglet diarrhea and preparation method of traditional Chinese medicine composition |
| CN104970198A (en) * | 2015-06-29 | 2015-10-14 | 何以安 | Feed additive for preventing and treating diarrhoea of cows |
| CN105010826A (en) * | 2015-06-29 | 2015-11-04 | 何以安 | Lamb diarrhea preventing and curing feed additive |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103202909B (en) | 2014-12-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103893272B (en) | A kind of pharmaceutical composition and preparation method for the treatment of livestock dysentery | |
| CN103860714B (en) | A kind of compound Chinese medicine extract and application thereof preventing and treating livestock and poultry diarrhea syndrome | |
| CN103006792A (en) | Veterinary drug for preventing livestock bowel diseases, preparation method of drug, and feed | |
| CN103202899B (en) | Traditional Chinese medicine feed additive for preventing and curing livestock and poultry diarrhea | |
| CN106039248A (en) | Formula for traditional Chinese medicines for treating different types of porcine diarrhea | |
| CN103202962B (en) | Chinese herbal medicine feed additive for preventing and curing colibacillosis | |
| CN103202909B (en) | Traditional Chinese medicine feed additive for preventing and curing diarrhea of livestock and poultry as well as fur-bearing animals | |
| CN104013678A (en) | Traditional Chinese medicine composition for controlling avian flu and Newcastle disease and fryer culture method by using the composition | |
| CN103340973B (en) | Veterinary traditional Chinese medicine composition for treating intestinal bacterial infection as well as preparation method and application thereof | |
| CN101342273B (en) | Medicament for preventing and controlling botryomycosis of chicken | |
| CN103202908B (en) | Chinese herbal medicine feed additive for preventing and curing colibacillosis | |
| CN104147327A (en) | Pharmaceutical preparation for bacillary dysentery of piglets | |
| CN103006820A (en) | Chinese medicinal composition with functions of clearing heat and drying dampness and preparation method thereof | |
| CN103202894B (en) | Chinese herbal medicine feed additive for preventing and curing infectious serositis of duck | |
| CN101670005B (en) | Anticoccidiosis pharmaceutical composition and preparation method and use thereof | |
| CN103202900B (en) | Traditional Chinese medicine feed additive for preventing and curing livestock and poultry diarrhea | |
| CN103800464B (en) | A kind of Chinese medicine composition for the treatment of yellow and white dysentery of piglet | |
| CN104825753B (en) | A kind of Chinese medicine composition for prevention newborn piglet diarrhea of being taken medicine by sow | |
| CN106344900A (en) | Traditional Chinese medicine composition for treating intractable diarrhea of infant deer, and preparation method thereof | |
| CN102961563B (en) | Pharmaceutical composition for treating livestock and poultry dysentery and preparation method thereof | |
| CN102488767B (en) | Compound composition for treating bacterial diarrhoea of livestock and poultry | |
| CN101664434A (en) | Composite traditional Chinese medicine composition and preparation method and application thereof | |
| CN104367670A (en) | Traditional Chinese medicine granules for preventing and treating piglet bacterial enteritis and preparation method thereof | |
| CN105250825A (en) | Traditional Chinese medicine composition for treating and preventing livestock, poultry and fur-bearing animal gastroenteritis | |
| CN101313925B (en) | Sanshi detoxication powder |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Chen Pengju Inventor after: Liu Yan Inventor after: Wang Jun Inventor after: He Guifen Inventor after: Shen Junhong Inventor after: Han Fei Inventor after: Wang Feifei Inventor after: Li Wei Inventor after: Gao Xupu Inventor before: Chen Pengju |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: CHEN PENGJU TO: CHEN PENGJU LIU YAN WANG JUN HE GUIFEN SHEN JUNHONG HAN FEI WANG FEIFEI LI WEI GAO XUPU |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180711 Address after: 450000 2, Xingye Road, Sun Zhuang Baihui Chinese herbal logistics base, ancient town, Hui Ji District, Zhengzhou, Henan Patentee after: HENAN RUIZHIHENG BIOLOGICAL TECHNOLOGY Co.,Ltd. Address before: No.9 Building, No.50 Wenbei Road, Zhengzhou City, Henan Province, 450002 Patentee before: Chen Pengju |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20191204 Address after: Room 708, block B, No.7, Dongqing street, high tech Development Zone, Zhengzhou City, Henan Province Patentee after: Henan Institute of Modern Chinese Veterinary Medicine Address before: 450000 2, Xingye Road, Sun Zhuang Baihui Chinese herbal logistics base, ancient town, Hui Ji District, Zhengzhou, Henan Patentee before: HENAN RUIZHIHENG BIOLOGICAL TECHNOLOGY Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231014 Address after: No. 601, 6th Floor, Building B, Building 3, No. 7 Guoji Road, Jinshui District, Zhengzhou City, Henan Province, 450000 Patentee after: Henan Kangle Bioengineering Co.,Ltd. Address before: Room 708, block B, No.7 Dongqing street, high tech Development Zone, Zhengzhou, Henan 450000 Patentee before: Henan Institute of Modern Chinese Veterinary Medicine |