CN104840934A - Traditional Chinese medicine composition for preventing and treating piglet diarrhea and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for preventing and treating piglet diarrhea and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for preventing and treating piglet diarrhea and belongs to the field of veterinary medicine preparation. The traditional Chinese medicine composition is prepared from the following Chinese herbal components in parts by weight: 8-12 parts of Chinese pulsatilla root, 1-3 parts of dangshen, 1-3 parts of red peony root, 1-3 parts of bighead atractylodes rhizome, 1-3 parts of dried ginger, 1-3 parts of dried orange peel, 1-3 parts of golden cypress and 1-3 parts of liquorice root. The traditional Chinese medicine composition is prepared from pure Chinese herbal medicinal materials which are wide in source and low in cost; the traditional Chinese medicine composition is free from residue and toxic and side effects; especially, the Chinese herbal medicinal materials are extracted by virtue of decocting in water, and therefore, the traditional Chinese medicine process is kept and the traditional Chinese medicine can be absorbed more easily. The traditional Chinese medicine composition has remarkable effects of clearing away heat and toxic materials, eliminating dampness and stopping dysentery, warmly invigorating stomach and intestine and regulating the functions of the organism, and is capable of effectively treating various types of diarrhea and shortening the recovery phase. The traditional Chinese medicine composition is convenient to use. Clinical tests prove that the cure rate of the traditional Chinese medicine composition is not less than 85% and a unique curative effect can be achieved.
Description
Technical field
The invention belongs to veterinary drug preparation field, relate to a kind of Chinese medicine composition and preparation method of prevention and therapy piglet diarrhea particularly.
Background technology
Piglet diarrhea is the typical multifactor property disease of the one under intensive pig production working condition, and this disease is one of the most serious current piglet diseases group, is also the major reason causing piglet death.It is reported, the piglet of below 30kg, average of the whole year sickness rate 46.5%, mortality rate 10.3%.Piglet diarrhea ranks first in pig industry harm, and the piglet mortality rate of China is generally 15 ~ 20%, Suprapubic arch sling average 11 ~ 25%.Die of illness piglet more than 80% for dysentery death.
Diarrhea of weaned piglets disease accounts for piglet diarrhea significant proportion, and sickness rate is very high, and throughout the year all can be popular.Its pathogenic factor is a lot, also very complicated, but mainly stress causes.Early weaning piglet to refer to wean after 8 week age of traditional piglet ahead of time to the production technology that 3 ~ 5 weeks age weaned, and has progressively applied segregated early weaning (SEW) abroad from the sixties.Domesticly take up this production technology of research application from the end of the seventies, the beginning of the eighties at some large―scale hoggery, to the end of the eighties, the beginning of the nineties, general field carries out the method weaned in 3 ~ 4 week age of piglet all substantially.But, early weaning production on demonstrate very high potential while, incident be due to early weaning cause stress, cause early weaning syndrome.A series of clinical symptoms such as clinical signs is inappetence in wean 5 days, drink hangs for increases, growth retardation, Mao Jiao tripe, suffer from diarrhoea, edema.Wherein diarrhoea is the most common also the most serious a kind of phenomenon.
The reason of piglet diarrhea is complicated, concludes to be roughly divided into the following aspects:
1) self dysplasia causes digestive function, Development of Digestive Organs incomplete, thus affects the nutrition of piglet normal absorption, causes impaired development; Wean early, immunity is weak, weak to the immunne response ability of cause of disease invasion, can not produce positive immunne response, exogenous antinutritional factor a large amount of in addition such as globulin, β-poly-globulin and Protein-Carbohydrate complex cause piglet gastrointestinal tract that abnormal immunoreactive main antigenic substance occurs; Gastric acid deficiency also can cause pathogen amount reproduction, causes and digests and assimilates bad, the diseases such as dysentery of suffering from diarrhoea; The activity of the digested enzyme of digestive tract is low in addition, also can affect the absorption and digestion to feedstuff.
2) exogenous cause pathogeny imcrobe infection, comprises antibacterial as escherichia coli, Salmonella, spirillum etc., and virus has piglet diarrhea virus, transmissible gastroenteritis, rotavirus etc.
Chinese veterinarian thinks that the reason causing piglet diarrhea is a lot, but main or due to feeding and management bad, climate variability, being invaded by exogenous pathogen, injury due to diet, internal organs void declines and the factor such as visceral dysfunction causes.Piglet diarrhea exopathogenic factor is the most obvious with wet relation of containing; Endogenous cause of ill is relevant with taste.Due to spleen preferring dryness to dampness, the transporting of main fresh food and water, temper should rise; Stomach tide hundred arteries and veins, preferring moisture to dryness, master is become thoroughly decomposed, and gastric qi should be fallen, the function that both complete jointly " transporting and transforming nutrients from foodstuff, ascending the clear and descending the turbid ".Any exopathogen or internal injury factor affect spleen and stomach function, transporting can be caused to lack of proper care, become thoroughly decomposed unable, and food of receiving is not good, clear QI being mixed up with turbid QI, and conduction dereliction of duty, forms diarrhoea.Because body is empty or for a long time sick, damage kidney yang, fatal fire is not enough and be difficult the yang-energy of spleen soil, then can increase the weight of the state of an illness.
Summary of the invention
The invention provides a kind of Chinese medicine composition and preparation method of prevention and therapy piglet diarrhea, the present invention is theoretical to piglet diarrhea determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs according to Chinese veterinarian, and screening prescription compatibility, has remarkable result to the prevention and therapy of piglet diarrhea, and have no side effect.
The present invention is achieved by the following technical solutions:
A Chinese medicine composition for prevention and therapy piglet diarrhea, it comprises following Chinese medicinal ingredients and weight portion: the Radix Pulsatillae 8 ~ 12 parts, Radix Codonopsis 1 ~ 3 part, Radix Paeoniae Rubra 1 ~ 3 part, the Rhizoma Atractylodis Macrocephalae 1 ~ 3 part, Rhizoma Zingiberis 1 ~ 3 part, Pericarpium Citri Reticulatae 1 ~ 3 part, Cortex Phellodendri 1 ~ 3 part, 1 ~ 3 part, Radix Glycyrrhizae composition.Full side plays effect of heat-clearing and toxic substances removing, strengthening the spleen and nourishing the stomach, strengthening vital QI to eliminate pathogenic factors, dampness-eliminating and dysentery-stopping altogether.
A kind of preparation method of Chinese medicine composition of prevention and therapy piglet diarrhea, by described 8 ~ 12 portions of Radix Pulsatillaes, 1 ~ 3 part of Radix Codonopsis, 1 ~ 3 part of Radix Paeoniae Rubra, 1 ~ 3 part of Rhizoma Atractylodis Macrocephalae, 1 ~ 3 portion of Rhizoma Zingiberis, 1 ~ 3 part of Pericarpium Citri Reticulatae, 1 ~ 3 portion of Cortex Phellodendri, 1 ~ 3 part of Radix Glycyrrhizae water drug-decocting concentrating liquid prepares extractum, medicinal residues crushed after being dried after extraction, cross 8 ~ 20 mesh sieves, obtain medicinal residues powder, in extractum: cane sugar powder (weight ratio) 1:1 ratio adds cane sugar powder in extractum, stir, according to dry wet situation, add medicinal residues powder, stir (pinch with hands and be shaped to principle), rear drying is prepared into granule and crosses 8 ~ 20 mesh sieves, subpackage and get final product.
The using method of described composition of medicine, add 20 ~ 60 grams of described compositionss according to per kilogram feedstuff during use, mixed feeding 3 ~ 5 days is a course for the treatment of.
Herbal control piglet diarrhoea demonstrates good momentum, and Chinese herbal medicine not only can prevent and treat piglet diarrhoea, also can solve drug residue problem, has good development prospect.As the Radix Pulsatillae is proved to be a kind of effect with good heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, dampness-eliminating and dysentery-stopping, there is very high medical value, and distributed more widely, and all there is growth China various places, draw materials conveniently, cheap.
Radix Pulsatillae Classification system: Pulsatilla chinensis (Bunge) Regel), Ranunculaceae, Anemone herbaceos perennial, long have root stock, and blade is avette, calyx bluish violet.Another name has how grass, powder silkweed, Bai Toucao, old aunt grass etc.Be distributed between the hummock of the province such as Jilin, Liaoning, Hebei, Shandong, Henan, Shanxi, Shaanxi, Heilungkiang of China, barren hill and field, there is very high medical value.The Radix Pulsatillae has effect of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites.Radix Pulsatillae bitter in the mouth, cold in nature; Return stomach, large intestine channel, cure mainly pyretic toxicity dysentery, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, carbuncle skin ulcer, scrofula.The pharmacologic action of the Radix Pulsatillae mainly comprises: antioxidation, antiinflammatory action.Yao D etc. find that the Radix Pulsatillae has the release stoping peroxide in hepatic tissue, increase the activity of MnSOD, stop the infection of hepatitis B virus.Dragon Shengjing city etc. utilizes luminol luminescence system, and research finds that Radix Pulsatillae Aqueous extracts has stronger resistant activity Oxidation, effectively can remove hydrogen peroxide, prevents the lipid peroxidation caused by it and cause cell or tissue to damage.The research such as Zhang Wenyuan finds that Radix Pulsatillae Alcohol Extract has obvious inhibitory action to the rat colonitis that glucosan sulphuric acid is induced.Parasite killing, bacteriostasis.The research such as Lan Jiyu finds that Radix Pulsatillae decoct is better to the effect killing Entamoeba histolytica.Cao Jinghua etc. record Radix Pulsatillae Aqueous extracts with K-B disk diffusion method and have obvious inhibitory action to staphylococcus aureus, bacillus pyocyaneus, anthrax bacillus, Bacillus typhi, alpha streptococcus, group B streptococcus.Enhancing human body immunity function.After adding variable concentrations Radix Pulsatillae glycoprotein in the Turnover of Mouse Peritoneal Macrophages that Dai Ling etc. cultivate in vitro, Turnover of Mouse Peritoneal Macrophages is engulfed neutral erythrocytic effect and is significantly strengthened, and macrophage can be induced produce carbon monoxide, macrophages secrete IL-1 is also improved effect.Antioxidation.Show according to current research, the saponin of the Radix Pulsatillae 5 glycosyls is changed over low sugar saponin, be conducive to absorption of human body, and the enzymatic hydrolysate of pulchinenoside obviously can promote the collagen protein synthesis of skin fiber sprout cell, be mixed with anti-aging cosmetics with it, collagen protein amount in skin can be made obviously to increase, effectively improve skin elasticity, anti-wrinkle, defying age.Antiinflammatory action.Chronic colitis is one of clinical common difficult miscellaneous diseases.The Radix Pulsatillae has analgesia, calmness, spasmolytic and has astringing to arrest bleeding effect to intestinal mucosa.Adopt Radix Pulsatillae treatment chronic colitis can enhancing human body immunity power, promote the reparation of intestinal mucosa.Research finds, the mechanism of Radix Pulsatillae Decoction treatment ulcerative colitis is that it can reduce high humoral immunization and reduce by cytokine mediated immunoreation.
Radix Codonopsis (formal name used at school; Codonopsis pilosula) sheet of ovalize or similar round, surperficial yellowish-brown or lark, tangent plane yellow-white or yellowish-brown, have crack or Flos Chrysanthemi stricture of vagina, there are the faint yellow center of circle in central authorities.Periphery yellowish white puts yellowish-brown, has vertical wrinkle.Have special aroma, taste is micro-sweet.In the woods limit, mountain region of place of production north of China height above sea level 1560-3100 rice and shrubbery.The Codonopsis plant whole world about has 40 kinds, and China about has 39 kinds, and medicinal have 21 kinds, 4 mutation.Radix Codonopsis is traditional tonic that China commonly uses, and the Radix Codonopsis that ancient times produce with area, Shangdang, Shanxi is top grade, has invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.Modern study, Radix Codonopsis has enhancing immunity, blood vessel dilating, blood pressure lowering, improves microcirculation, strengthens the effects such as hemopoietic function.In addition castering action is had to the leukopenia that chemotherapy radiotherapy causes.
Raw Radix Codonopsis sheet supplementing QI for promoting the production of body fluid power victory.Be usually used in gas Tianjin two to hinder or deficiency of both QI and blood.Radix Codonopsis sweet in the mouth, property is put down.Have invigorating the spleen and replenishing QI, quench the thirst, spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.For deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, lazy speech is losed heart, myasthenia of limbs, be off one's feed, the deficiency of vital energy, gas Tianjin two are empty, QI and blood is two loses and the disease such as blood deficiency and yellow complexion.But exterior syndrome is not separated and can not the using of the fullness in the epigastrium and abdomen domination of pathogen.This product effect is similar to Radix Ginseng, and only the efficacy of a drug is weak.Control general deficiency syndrome, Radix Ginseng can be replaced to use; Collapse is heavily demonstrate,proved, then be still advisable with Radix Ginseng.Autumn excavates, and cleans, dries.
Radix Paeoniae Rubra is the dry root of Ranunculaceae Radix Paeoniae (Paeonia lactifloraPal.l) or river Radix Paeoniae Rubra (P.veitchiiLynch.).Its bitter in the mouth, is slightly cold, and returns Liver Channel, has clearing away heat and cooling blood, effect of dissipating blood stasis analgesia.Main component comprises monoterpene and the glycoside thereof of tool pinane structure, this compounds has peoniflorin, Hydroxy peoniflorin, benzoylpaeoniflorin, benzoyl-paeoniflorin, (2-hydroxybenzoyl) peoniflorin, lacdtlorin Ⅲ, 8 (Z)-(1S, 5R)-B pinene-10-hydroxyl-B-common vetch glucosides, lactone glucoside of Radix Paeoniae etc.; The monoterpene of tool lactone structure and glycoside thereof, this compounds has paeonilactone A, B, C; Lactinolide, 6-O-B-D-glucopyranosyl-lactinolide etc.Still there are oxypaeoniflorin, peonin, Radix Paeoniae aglycon, galloylpaeoniflorin etc. in addition.
The pharmacological action of Radix Paeoniae Rubra comprises the effect to blood system.Pharmaceutical research shows Radix Paeoniae Rubra anticoagulant, improves erythrocytic permeability, increases erythrocyte to the resistance of hypotonic tension force, has the effect of necessarily stablizing erythrocyte membrane structure.In addition, the clotting time of the obvious prolong rats of Radix Paeoniae Rubra total glycosides energy and mice, and the electricity irritation rat carotid artery thrombotic time can be extended, prompting Radix Paeoniae Rubra total glycosides produces anti thrombotic action by the impact on blood coagulation system and platelet function.To cardiovascular effect.Radix Paeoniae Rubra is traditional blood-activating stasis-removing kind Chinese medicine, has stronger study of anti-atherogenic effect, and this medicine also can dilating coronary blood vessel, increases coronary flow thus increases cardiac muscle nutritional blood flow; Protection ischemic myocardium, improves the toleration of cardiac muscle to hypoxia; Reduce pulmonary vascular resistance, alleviate afterload.Radix Paeoniae Rubra can reduce portal hypertension simultaneously, also has impact to microcirculation.To the effect of tumor.The activity of adenosine triphosphate (ATP) enzyme and the effect of rising adenylate cyclase activity on peoniflorin energy inhibition tumor cell film.Zhu Jianhua etc. have carried out mutagenicity and ant-imutagenicity experiment to Radix Paeoniae Rubra water-soluble extracting liquid, and result display Radix Paeoniae Rubra water-soluble extracting liquid exists obvious antimutagenesis, and strengthens with the increase of concentration.To the effect of liver.The drug for invigorating blood circulation and eliminating stasis such as Radix Paeoniae Rubra have eliminating jaundice, suppress thromboxane B2 in blood plasma to produce, promote the effect of liver hydrolysis, anti-hepatic fibrosis, promotion liver cell regeneration.Radix Paeoniae Rubra also has antiinflammatory, anti-allergy action, the effect of scavenging capacity oxygen-derived free radicals, also has strengthening by means of tonics effect, also has certain effect to nervous system.
The Rhizoma Atractylodis Macrocephalae is one of China's conventional Chinese medicine, for the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephalaKoidz., warm in nature, sweet in the mouth, hardship, there is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, be used for the treatment of deficient QI of the spleen and stomach, have loose bowels, sweating, frequent fetal movement etc.Main product in Zhejiang, Anhui, with Yinxian County, Zhejiang, Xinchang area output maximum, what dive produce performance optimal, spy is called " what art ", have spleen reinforcing, stomach reinforcing, dampness and in effect.The chemical composition of the Rhizoma Atractylodis Macrocephalae is comparatively complicated, existing known main containing volatile oil, lactone, polysaccharide.Volatile oil about contains 1.4% in Rhizoma Atractylodis Macrocephalae rhizome, its main component is atractylone (atratylon), atractylol etc., Rhizoma Atractylodis Macrocephalae ethanol percolate extraction, silica gel chromatography is separated, use petroleum ether-ether gradient eluting again, obtain atractylenolide Ⅰ (atractylenolide I), atractylenolideⅡ (atractylenolide II), atractylenolideⅢ (atractyl-enolide III), 8B-ethyoxyl atractylenolideⅢ (8B-ethoxyatractylenolide III).Containing Rhizoma Atractylodis polysaccharide PM, mannan Am-3 etc. in the Rhizoma Atractylodis Macrocephalae.Rhizoma Atractylodis Macrocephalae water extraction hypostasis is separated obtains PSAM-1, PSAM-2 two heteropolysaccharide through 732 strongly acidic cation-exchanges, borate type DEAE-cellulose post.In addition, in the Rhizoma Atractylodis Macrocephalae also containing 12A-methylbutyryl-14-acetyl-8-highlights art triol along Rhizoma Atractylodis Macrocephalae triol, 12A-methylbutyryl-14 acetyl-8-, 14A-methylbutyryl-8-highlights art triol [5], Rhizoma Atractylodis Macrocephalae lactams (atratylenolactam), alnulin acetas (taraxerylacetate), juniper camphor (junipercomphor), Palmic acid, B-amyrin acetas, C-sitosterol, B-sitosterol, C-spinach sterol along Rhizoma Atractylodis Macrocephalae triol, 14A-methylbutyryl-8-.Also containing 14 seed amino acids and the many kinds of substances such as resin, vitamin A such as glutamic acid in the Rhizoma Atractylodis Macrocephalae.
The Rhizoma Atractylodis Macrocephalae is the most frequently used Qi-tonifying drug, there is effect of invigorating the spleen and replenishing QI, dampness diuretic, strengthening superficial resistance to stop perspiration, modern age, pharmaceutical research showed that the Rhizoma Atractylodis Macrocephalae had immunomodulating, diuresis, antitumor, anti-inflammation, blood sugar lowering, the anti-ageing effect of waiting for a long time, also certain effect is had to nervous system, digestive tract, uterine smooth muscle, can also immunity moderation function.
Cortex Phellodendri has another name called Cortex Phellodendri, Cortex Phellodendri; Mongolian medicine name: Xia Mao, is the dry bark of rutaceae wampee Phellodendron chinense Schneid. or Cortex Phellodendri Phello-dendron amurense Rupr.The provinces such as lodh tree main product China Sichuan, Guizhou.The provinces such as Cortex Phellodendri main product Jilin, Liaoning, Heilungkiang.Chinese medicine is thought: Cortex Phellodendri bitter in the mouth cold in nature, and main kidney, urinary bladder channel, have effect of heat clearing and damp drying, eliminating fire and detoxication, clearing away deficiency-heat, is mainly used to treat gastroenteropathy.Research shows, Cortex Phellodendri has resisting pathogenic microbes effect: record according to [PhytotherRes], the Mice Auricle inflammation that the alcohol extract xylol of Cortex Phellodendri and Rhizoma Coptidis brings out has obvious inhibitory action (P<0.05); Compound phellodendron bark vena axillaris injects 200mg (kg), produces the bacteriostasis same with quiet note dexamethasone 100mlPmg.Cortex Phellodendri is inhibited to gastric ulcer: have experiment to prove, remove alkaloidal Cortex Phellodendri water soluble ingredient and can suppress stress stress the reduction of SOD in Mice activity, before can making water logging, PFE2 amount significantly increases, and have suppress water logging after the trend that reduces of PGE2 amount.Illustrate that it has inhibitory action to gastric ulcer.
The compatibility of Chinese medicine composition needs to carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs according to Chinese veterinarian's theory to disease, and screening prescription, reasonable compatibility, just can reach prevention of disease and treatment has remarkable result.Therefore, the pharmacological action that the medicine that compatibility is different embodies is also different.The medicine phases 5 such as the above-mentioned Radix Pulsatillae, Radix Codonopsis, Radix Paeoniae Rubra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Cortex Phellodendri, Radix Glycyrrhizae, full side plays effect of heat-clearing and toxic substances removing, strengthening the spleen and nourishing the stomach, strengthening vital QI to eliminate pathogenic factors, dampness-eliminating and dysentery-stopping altogether.
The present invention's beneficial effect compared with prior art: the present invention is with anti-inflammation, dysentery relieving hemostasis, raising immunity of organisms, reparation function of intestinal canal for the rule for the treatment of, and reasonable recipe, preparation technology is simple, applied widely.The present invention adopts pure Chinese medicinal herbs to make, and wide material sources, cost are low, and cure rate is high, and medicine noresidue, has no side effect, and particularly extracting with crossing decocting, maintaining Chinese medicine technique, is easier to absorb.Have the effect of significant heat-clearing and toxic substances removing, dampness-eliminating and dysentery-stopping, temperature compensation gastrointestinal and adjustment body function, effectively all kinds of diarrhoea for the treatment of, shortens the period of convalescence.Easy to use.Clinical trial proves, cure rate reaches more than 85%, has unique curative effect.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
By weight 8000g:1000g:1000g:1000g:1000g:1000g:1000g:1000g, take the Radix Pulsatillae, Radix Codonopsis, Radix Paeoniae Rubra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Cortex Phellodendri, Radix Glycyrrhizae, above eight taste Chinese herbal medicine are decocted with water 2 times, each 0.5 hour, collecting decoction, filtered, filtrate concentrates to obtain extractum, medicinal residues crushed after being dried after extraction, crosses 8 mesh sieves, obtains medicinal residues powder.In extractum: cane sugar powder (weight ratio) 1:1 ratio adds cane sugar powder in extractum, stirs, and adds appropriate medicinal residues powder, stir to hands and pinch in bulk, rear drying is prepared into granule and crosses 10 mesh sieves, subpackage after dry; During piglet diarrhoea all kinds of for prevention and therapy, in feedstuff, add 10g according to per kilogram feedstuff, mixed feeding, is used in conjunction 3 days.
Embodiment 2
By weight 9000g:1500g:1500g:1000g:1000g:1000g:1000g:1000g, take the Radix Pulsatillae, Radix Codonopsis, Radix Paeoniae Rubra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Cortex Phellodendri, Radix Glycyrrhizae, above eight taste Chinese herbal medicine are decocted with water 2 times, each 0.5 hour, collecting decoction, filtered, filtrate concentrates to obtain extractum, medicinal residues crushed after being dried after extraction, crosses 10 mesh sieves, obtains medicinal residues powder.In extractum: cane sugar powder (weight ratio) 1:1 ratio adds cane sugar powder in extractum, stirs, and adds appropriate medicinal residues powder, stir to hands and pinch in bulk, rear drying is prepared into granule and crosses 15 mesh sieves, subpackage after dry.During piglet diarrhoea all kinds of for prevention and therapy, in feedstuff, add 20g according to per kilogram feedstuff, mixed feeding, is used in conjunction 4 days.
Embodiment 3
By weight 10000g:2000g:1000g:1500g:1500g:1500g:1500g:1500g, take the Radix Pulsatillae, Radix Codonopsis, Radix Paeoniae Rubra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Cortex Phellodendri, Radix Glycyrrhizae, above eight taste Chinese herbal medicine are decocted with water 2 times, each 0.5 hour, collecting decoction, filtered, filtrate concentrates to obtain extractum, medicinal residues crushed after being dried after extraction, crosses 15 mesh sieves, obtains medicinal residues powder.In extractum: cane sugar powder (weight ratio) 1:1 ratio adds cane sugar powder in extractum, stirs, and adds appropriate medicinal residues powder, stir to hands and pinch in bulk, rear drying is prepared into granule and crosses 20 mesh sieves, subpackage after dry.During piglet diarrhoea all kinds of for prevention and therapy, in feedstuff, add 30g according to per kilogram feedstuff, mixed feeding, is used in conjunction 5 days.
Embodiment 4
By weight 10000g:2000g:1000g:1500g:1500g:1500g:1500g:1500g, take the Radix Pulsatillae, Radix Codonopsis, Radix Paeoniae Rubra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Zingiberis, Pericarpium Citri Reticulatae, Cortex Phellodendri, Radix Glycyrrhizae, above eight taste Chinese herbal medicine are decocted with water 2 times, each 0.5 hour, collecting decoction, filtered, filtrate concentrates to obtain extractum, medicinal residues crushed after being dried after extraction, crosses 20 mesh sieves, obtains medicinal residues powder.In extractum: cane sugar powder (weight ratio) 1:1 ratio adds cane sugar powder in extractum, stirs, and adds appropriate medicinal residues powder, stir to hands and pinch in bulk, rear drying is prepared into granule and crosses 20 mesh sieves, subpackage after dry.During piglet diarrhoea all kinds of for prevention and therapy, in feedstuff, add 30g according to per kilogram feedstuff, mixed feeding, is used in conjunction 5 days.
Clinical trial:
Example 1:
Certain pig farm, Fushan, Landrace
This raises Chang-Bai piglet 1000, and wean latter 3 days approximately dead 150 (mortality rate 15%), and other about 200 occur diarrhoea, draw watery stools, inappetence.Clinical and laboratory diagnosis is the bacillary piglet diarrhea that escherichia coli cause, and the morbidity Piglet by Oral antibiotic of 100 is as enrofloxacin etc., and rehabilitation 30, still has 55 hairs sick by dead 15.Owing to cannot thoroughly cure, finally this part piglet is eliminated.The pharmaceutical composition of the sick Piglet by Oral embodiment 1 of all the other 100 hairs, within 4 days, sequela piglet is down to 15, dead 5, and all the other 80 rehabilitations are also raised to 150 days, all deliver for sale.
To the pharmaceutical composition of the whole oral embodiment 1 of the piglet do not fallen ill, there is not piglet diarrhea symptom, raise to 150 days, all deliver for sale.
Example 2:
Certain pig farm, Laiyang, Yantai, duroc
This raises piglet 1500, wean rear 2 days 500 there is dysentery, draw watery stools, inappetence, dead 210.Clinical and laboratory diagnosis is the piglet diarrhoea of rotavirus infection, and 250 hairs sick Piglet by Oral antibiotic enrofloxacin etc., rehabilitation 45, still has 130 hairs sick by dead 75.The pharmaceutical composition of the sick Piglet by Oral embodiment 2 of another 250 hairs, is down to 10 with sequela piglet in 3 days, dead 3, all the other 237 rehabilitations, and last all health to 150 days of feeding is delivered for sale.After raise again a collection of to wean 3 days time, occur same clinical symptoms, after being judged as rotavirus infection, full group orally uses pharmaceutical composition and the using method of inventive embodiments 2,3 days afterwards suffer from diarrhoea the state of an illness controlled, piglet only dead 5, successful.
Example 3:
Certain pig farm, Yantai, local varieties Black Hills pig
This raises piglet 2000, wean rear 2 days 900 there is dysentery, draw watery stools, inappetence, dead 310.Clinical and laboratory diagnosis is the piglet diarrhea that piglet diarrhea virus infects, 300 hairs sick Piglet by Oral antibiotic enrofloxacin etc., rehabilitation 60, still has 150 hairs sick by dead 90.The pharmaceutical composition of the sick Piglet by Oral embodiment 3 of another 300 hairs, is down to 12 with sequela piglet in 3 days, dead 5, all the other 283 rehabilitations, and last all health to 150 days of feeding is delivered for sale.Remain the medicine that 300 draught animals take embodiment 4, within 3 days, be down to 8 with sequela piglet, dead 3, all the other 289 rehabilitations, last all health to 150 days of feeding is delivered for sale.After raise again a collection of to wean latter 2 days time, there is same clinical symptoms, after being judged as rotavirus infection, half orally uses pharmaceutical composition and the using method of inventive embodiments 3, second half uses pharmaceutical composition and the using method of inventive embodiments 3, the state of an illness of suffering from diarrhoea afterwards for 3 days is controlled, piglet only dead 5, successful.
Medicine of the present invention has no side effect, easy to use.
Above-mentioned detailed description of the Chinese medicine composition of prevention and therapy piglet diarrhea being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. a Chinese medicine composition for prevention and therapy piglet diarrhea, is characterized in that it comprises following Chinese medicinal ingredients and weight portion: the Radix Pulsatillae 8 ~ 12 parts, Radix Codonopsis 1 ~ 3 part, Radix Paeoniae Rubra 1 ~ 3 part, the Rhizoma Atractylodis Macrocephalae 1 ~ 3 part, Rhizoma Zingiberis 1 ~ 3 part, Pericarpium Citri Reticulatae 1 ~ 3 part, Cortex Phellodendri 1 ~ 3 part, 1 ~ 3 part, Radix Glycyrrhizae composition.
2. the preparation method of Chinese medicine composition according to claim 1, it is characterized in that its step: by described 8 ~ 12 portions of Radix Pulsatillaes, 1 ~ 3 part of Radix Codonopsis, 1 ~ 3 part of Radix Paeoniae Rubra, 1 ~ 3 part of Rhizoma Atractylodis Macrocephalae, 1 ~ 3 portion of Rhizoma Zingiberis, 1 ~ 3 part of Pericarpium Citri Reticulatae, 1 ~ 3 portion of Cortex Phellodendri, 1 ~ 3 part of Radix Glycyrrhizae water drug-decocting concentrating liquid prepares extractum, medicinal residues crushed after being dried after extraction, cross 8 ~ 20 mesh sieves, obtain medicinal residues powder, in extractum: cane sugar powder (weight ratio) 1:1 ratio adds cane sugar powder in extractum, stir, add medicinal residues powder, stir, rear drying is prepared into granule and crosses 8 ~ 20 mesh sieves, subpackage and get final product.
3. the application process of Chinese medicine composition described in claim 1 or 2, add 20 ~ 60 grams of described Chinese medicine compositions according to per kilogram feedstuff when it is characterized in that described composition of medicine uses, mixed feeding 3 ~ 5 days is a course for the treatment of.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104996840A (en) * | 2015-08-20 | 2015-10-28 | 兴安县森澳养殖有限公司 | Pig starter feed additive for preventing and treating diarrhoea |
| CN104996842A (en) * | 2015-08-20 | 2015-10-28 | 兴安县森澳养殖有限公司 | Piglet feed additive |
| CN105010889A (en) * | 2015-08-20 | 2015-11-04 | 兴安县森澳养殖有限公司 | Chinese herbal medicine piglet feed additive |
| CN106177834A (en) * | 2016-07-18 | 2016-12-07 | 安徽奥力欣生物科技有限公司 | A kind of Chinese medicine microecological preparation treating Intestinum Sus domestica tract disease and preparation method thereof |
| CN106819475A (en) * | 2017-02-09 | 2017-06-13 | 合肥隆扬农业科技有限公司 | A kind of feed of prevention of diarrhea in piglets |
| CN110354217A (en) * | 2019-06-28 | 2019-10-22 | 江苏合纵思远生物科技有限公司 | A kind of Chinese medical extract that treating grice diarrhoea and preparation method |
| CN110892951A (en) * | 2019-11-22 | 2020-03-20 | 中国农业大学 | Method for preparing piglet anti-diarrhea feed by using anaerobic enzymolysis composite traditional Chinese medicine residues |
| CN112023018A (en) * | 2020-10-23 | 2020-12-04 | 广西壮族自治区兽医研究所 | Traditional Chinese medicine composition for preventing and treating livestock diarrhea and preparation method and application thereof |
| CN113615773A (en) * | 2017-04-14 | 2021-11-09 | 浙江艾杰斯生物科技有限公司 | Feed additive containing lysozyme and traditional Chinese medicine extract |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102524579A (en) * | 2012-01-12 | 2012-07-04 | 福建省莆田市优利可农牧发展有限公司 | Traditional Chinese medicine additive for pig feed and preparation method and application for traditional Chinese medicine additive |
| CN103202909A (en) * | 2013-04-01 | 2013-07-17 | 陈鹏举 | Traditional Chinese medicine feed additive for preventing and curing diarrhea of livestock and poultry as well as fur-bearing animals |
| CN103860714A (en) * | 2013-05-07 | 2014-06-18 | 武汉市畜牧兽医科学研究所 | Compound traditional Chinese medicine extract for preventing and treating livestock diarrhea syndrome and application thereof |
-
2015
- 2015-06-11 CN CN201510317143.XA patent/CN104840934A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102524579A (en) * | 2012-01-12 | 2012-07-04 | 福建省莆田市优利可农牧发展有限公司 | Traditional Chinese medicine additive for pig feed and preparation method and application for traditional Chinese medicine additive |
| CN103202909A (en) * | 2013-04-01 | 2013-07-17 | 陈鹏举 | Traditional Chinese medicine feed additive for preventing and curing diarrhea of livestock and poultry as well as fur-bearing animals |
| CN103860714A (en) * | 2013-05-07 | 2014-06-18 | 武汉市畜牧兽医科学研究所 | Compound traditional Chinese medicine extract for preventing and treating livestock diarrhea syndrome and application thereof |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104996840A (en) * | 2015-08-20 | 2015-10-28 | 兴安县森澳养殖有限公司 | Pig starter feed additive for preventing and treating diarrhoea |
| CN104996842A (en) * | 2015-08-20 | 2015-10-28 | 兴安县森澳养殖有限公司 | Piglet feed additive |
| CN105010889A (en) * | 2015-08-20 | 2015-11-04 | 兴安县森澳养殖有限公司 | Chinese herbal medicine piglet feed additive |
| CN106177834A (en) * | 2016-07-18 | 2016-12-07 | 安徽奥力欣生物科技有限公司 | A kind of Chinese medicine microecological preparation treating Intestinum Sus domestica tract disease and preparation method thereof |
| CN106819475A (en) * | 2017-02-09 | 2017-06-13 | 合肥隆扬农业科技有限公司 | A kind of feed of prevention of diarrhea in piglets |
| CN113615773A (en) * | 2017-04-14 | 2021-11-09 | 浙江艾杰斯生物科技有限公司 | Feed additive containing lysozyme and traditional Chinese medicine extract |
| CN113615773B (en) * | 2017-04-14 | 2023-07-25 | 浙江艾杰斯生物科技有限公司 | Feed additive containing lysozyme and traditional Chinese medicine extracts |
| CN110354217A (en) * | 2019-06-28 | 2019-10-22 | 江苏合纵思远生物科技有限公司 | A kind of Chinese medical extract that treating grice diarrhoea and preparation method |
| CN110892951A (en) * | 2019-11-22 | 2020-03-20 | 中国农业大学 | Method for preparing piglet anti-diarrhea feed by using anaerobic enzymolysis composite traditional Chinese medicine residues |
| CN112023018A (en) * | 2020-10-23 | 2020-12-04 | 广西壮族自治区兽医研究所 | Traditional Chinese medicine composition for preventing and treating livestock diarrhea and preparation method and application thereof |
| CN112023018B (en) * | 2020-10-23 | 2022-04-05 | 广西壮族自治区兽医研究所 | Traditional Chinese medicine composition for preventing and treating livestock diarrhea and preparation method and application thereof |
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Application publication date: 20150819 |