CN101670005B - Anticoccidiosis pharmaceutical composition and preparation method and use thereof - Google Patents
Anticoccidiosis pharmaceutical composition and preparation method and use thereof Download PDFInfo
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- CN101670005B CN101670005B CN2009100935569A CN200910093556A CN101670005B CN 101670005 B CN101670005 B CN 101670005B CN 2009100935569 A CN2009100935569 A CN 2009100935569A CN 200910093556 A CN200910093556 A CN 200910093556A CN 101670005 B CN101670005 B CN 101670005B
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Abstract
The invention discloses an anticoccidiosis pharmaceutical composition and a preparation method thereof. The pharmaceutical composition is a traditional Chinese medicine prepared by using fructus cnidii, antifebrile dichroa, radix sophorae flavescentis, radix scutellariae, purslane, hairyvein agrimony, angelica and radix codonopsitis as raw materials. The medicine is used for treating livestock coccidiosis with evident effect, and simultaneously has the advantages of safe use, low production cost, no toxic side-effect and the like.
Description
Technical field
The present invention relates to a kind of Anticoccidiosis pharmaceutical composition and preparation method thereof and purposes, belong to field of veterinary.
Background technology
Coccidiosis is a parasite very common in the domestic birds and animals body.Coccidiosis extensively distributes in China, is the great protozoacide of a kind of hazardness, is one of disease of the high control difficulty of sickness rate in the aviculture.Whole world every year because of coccidiosis cause with a toll of 1,500,000,000 dollars, wherein the year consumption of anticoccidial drug reaches 3.2 hundred million dollars.The U.S. spends in every year has 300,000,000 dollars wherein to have 100,000,000 to be to spend on the medicine approximately on the anticoccidial approximately.Britain estimated coccidiosis incidence rate 2%, mortality rate 0.5% in 2005.China deposited about 2,600,000,000 of cage laying hen in 2005, and year is delivered about 3,900,000,000 of broiler for sale, if can not effectively control coccidiosis, sickness rate can reach 50%-70%, and mortality rate reaches 20%-30%, reached 80% when serious.Coccidiosis has become the global disease that obstruction set reduction is supported the fowl production development.
Intensive culture factory is the optimum place of coccidiosis outburst, its case fatality rate is sometimes up to 40%, morbidity fowl group growth retardation, and when belonging to coccidium infection, tender Amy can significantly increase Salmonella infection, prolongation is to the time of environmental emission Salmonella, and Salmonella enteritidis pollutes phenomenons such as egg increases.Coccidiosis extensively has been present in broiler, meat rabbit plant at present.Show in investigation 12 feeding of broiler fields, Shanghai, there is a field coccidium infection rate of 70% to surpass 70%, extract 41 big investigation in Henan immediately and show, 35.3% field often break out repeatedly expense that coccidiosis and this area on average be used to prevent and treat coccidiosis up to 0.2-0.4 unit/.
Coccidiosis not only can cause fowl large quantities of morbidities only dead, but also causes price of deed reduction and growth promoter to be obstructed, and simultaneously easy concurrent other viral and bacterial diseasees cause serious economy loss.More headachy is that disease is sent out sequela later, is usually expressed as the hatching of breeding eggs rate and reduces, and the growth regularity of young fowl is poor, opens puerperal egg output and does not reach due peak, eggshell quality variation or the like.No matter the existence of coccidiosis just itself still is the chain negative effect that it brings, and all is extremely harmful economically.
At present, the method for preventing and treating of coccidiosis of domestic fowls mainly is to use coccidiostat, comprises polyethers ion carrier antibiotic and chemosynthesis coccidiostat, and using method is with anticoccidial drug spice or drinking-water between feeding period.In recent years, the coccidial vaccine of the broiler chicken special use that market has occurred, but from thorough control or to control the target of generation of coccidiosis preferably still far apart.The drug resistance of the residual and coccidiosis of coccidiostat makes the selectable active drug of control coccidiosis fewer and feweri, and the control of coccidiosis is difficulty further.
But Chinese herbal medicine has the little and worm of killing of toxic and side effects, strengthens body immunity function, growth promotion, coccidiosis and it is difficult for producing advantages such as drug resistance because of it, and is subjected to the favor of numerous veterinarys' veterinary drug researcher.Solve residual in meat that abuse of antibiotics, chemical synthetic drug bring, egg, the milk livestock products, drug resistance, toxic and side effects in an urgent demand at present both at home and abroad, and to today of problems such as human health works the mischief, make full use of the Chinese herbal medicine resource of China's abundant, under the modern medicine and pharmacology guide of theory, use the modern herbal medicine preparation of Chinese veterinarian's traditional theory and modern biotechnology exploitation anticoccidial and have great importance and wide application prospect.
Summary of the invention
The object of the present invention is to provide a kind of effective Anticoccidiosis pharmaceutical composition, especially for the pharmaceutical composition of treatment coccidiosis of domestic fowls.
Another object of the present invention provides this preparation of drug combination method and purposes.
The invention provides a kind of Anticoccidiosis pharmaceutical composition, it is characterized in that: it is the preparation that the ingredient by the following weight proportioning is prepared from:
Fructus Cnidii 10-25 part, Radix Dichroae 10-25 part, Radix Sophorae Flavescentis 10-25 part, Radix Scutellariae 8-20 part, Herba Portulacae 8-20 part, Herba Agrimoniae 8-20 part, Radix Angelicae Sinensis 5-15 part, Radix Codonopsis 5-15 part.
Further, the weight proportion of said medicine composition is as follows:
Fructus Cnidii 15-25 part, Radix Dichroae 15-25 part, Radix Sophorae Flavescentis 15-25 part, Radix Scutellariae 12-18 part, Herba Portulacae 12-18 part, Herba Agrimoniae 12-18 part, Radix Angelicae Sinensis 8-12 part, Radix Codonopsis 8-12 part.
Further, the weight proportion of said medicine composition is as follows:
20 parts of Fructus Cnidiis, 20 parts of Radix Dichroaes, 20 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Scutellariaes, 15 parts of Herba Portulacaes, 15 parts of Herba Agrimoniaes, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Codonopsis.
The present invention also provides the preparation method of this Anticoccidiosis pharmaceutical composition, and it comprises the steps:
(1) takes by weighing each ingredient by weight ratio;
(2) will claim each medicine material maybe will claim after pulverizing, sieving each medicine material after water or alcohol extraction, concentrating, add adjuvant or complementary composition commonly used in the pharmacy again, be prepared from.
The dosage form of the Anticoccidiosis pharmaceutical composition that the preparation method of Anticoccidiosis pharmaceutical composition of the present invention makes is: powder, powder, tablet, granule, oral liquid or injection.
Anticoccidiosis pharmaceutical composition of the present invention can be used for preparation treatment coccidiostat.
Anticoccidiosis pharmaceutical composition of the present invention more can be used for preparation treatment coccidiosis of domestic fowls medicine.
Each drug component in the pharmaceutical composition of the present invention and consumption thereof are to control principle according to the dialectical opinion of Chinese veterinarian's prescription, get by repeatedly practising in a large number, has heat-clearing and toxic substances removing, parasite killing goes to amass, the function of astringing to arrest bleeding, blood-supplementing blood-nourishing, after being prepared into preparation pharmaceutically commonly used, cure mainly poultry coccidiosis disease, particularly coccidiosis of domestic fowls etc.
The advantage and the good effect of medicine of the present invention are:
(1) medicine performance Chinese medicine organic conception of the present invention and the dialectical improvement opinion of executing, good effect, instant effect, treating both the principal and secondary aspects of a disease can be used for preventing and treating diseases such as chicken coccidiosis, el pato's parasitosis, rabbit coccidiosis, pig coccidiosis, dog coccidiosis;
(2) medicine of the present invention is a pure Chinese medicinal preparation, the drug residue that toxic and side effects is little, can not produce harm humans health, is difficult for producing drug resistance, free from environmental pollution;
(3) medicine of the present invention can be absorbed and bring into play due drug effect in animal body fast, can adopt modes such as mixing drink, mixed feeding to concentrate administration simultaneously, is beneficial to mass prevention and mass treatment;
(4) medicine material wide material sources of the present invention, production technology is simple, and production cost is low, has saved medication expense widely.
, it should be understood that described embodiment only is for the present invention is described, rather than limit the scope of the invention by any way more specific description the present invention by the following example.
The specific embodiment
Embodiment 1 medication preparation of the present invention and use
(1) take by weighing the raw material that contains following weight:
Fructus Cnidii 25g, Radix Dichroae 25g, Radix Sophorae Flavescentis 25g, Radix Scutellariae 20g, Herba Portulacae 20g, Herba Agrimoniae 20g, Radix Angelicae Sinensis 15g, Radix Codonopsis 15g.
(2) with claim in the step (1) each weight crude drug pulverize, sieve after, fully be mixed with into powder.
(3) drug use method of the present invention: coccidiosis, mixed feeding: every 1kg feedstuff, fowl 10g, logotype 7 days.
Embodiment 2 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
Fructus Cnidii 10g, Radix Dichroae 10g, Radix Sophorae Flavescentis 10g, Radix Scutellariae 8g, Herba Portulacae 8g, Herba Agrimoniae 8g, Radix Angelicae Sinensis 5g, Radix Codonopsis 5g.
(2) with claim in the step (1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours earlier after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into the thick paste shape; Filtering residue reuse water extraction 2 times extracted 2.5 hours for the first time, extracted 1.5 hours for the second time, filtered, and merging filtrate also is condensed into the thick paste shape; Merge extractum, add appropriate amount of starch and dextrin (or other adjuvant) at last, mix homogeneously is made soft material, granulates, and oven dry promptly is prepared into granule (every 1g is equivalent to crude drug in whole 2g).
(3) drug use method of the present invention: coccidiosis, mix drink: fowl, every 1L water adds this product 1.5g, freely drinks logotype 7 days.
Embodiment 3 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
20 parts of Fructus Cnidiis, 20 parts of Radix Dichroaes, 20 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Scutellariaes, 15 parts of Herba Portulacaes, 15 parts of Herba Agrimoniaes, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Codonopsis.
(2) with claim in the step (1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours earlier after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into the thick paste shape; Filtering residue reuse water extraction 2 times extracted 2.5 hours for the first time, extracted 1.5 hours for the second time, filtered, and merging filtrate also is condensed into the thick paste shape; Merge extractum, add appropriate amount of starch and dextrin (or other adjuvant) at last, mix homogeneously, oven dry is pulverized, and promptly is prepared into powder (every 1g is equivalent to crude drug in whole 1g).
(3) drug use method of the present invention: coccidiosis, mixed feeding: poultry, fowl, every 1kg feedstuff adds medicine 10g of the present invention, logotype 7 days.
Embodiment 4 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
Fructus Cnidii 25g, Radix Dichroae 25g, Radix Sophorae Flavescentis 25g, Radix Scutellariae 15g, Herba Portulacae 15g, Herba Agrimoniae 10g, Radix Angelicae Sinensis 10g, Radix Codonopsis 5g.
(2) with claim in the step (1) each weight proportion crude drug pulverize after, after water soaks 1 hour with medical material, decoct with high heat then to boiling, reuse slow fire boiling 30 minutes is filtered, filtering residue adds water with slow fire boiling twice, each 1 hour.Merging filtrate is concentrated into 130 milliliters with filtrate, and adding ethanol ethanol content to the filtrate is 70%, filters, and filtrate recycling ethanol is concentrated into every 1ml and is equivalent to crude drug in whole 1g, filter, and embedding, sterilization promptly is prepared into oral liquid.
(3) drug use method of the present invention: coccidiosis, mix drink: fowl, every 1L water adds this product 1.5ml, freely drinks logotype 7 days.
Embodiment 5 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
Fructus Cnidii 25g, Radix Dichroae 25g, Radix Sophorae Flavescentis 20g, Radix Scutellariae 15g, Herba Portulacae 10g, Herba Agrimoniae 10g, Radix Angelicae Sinensis 10g, Radix Codonopsis 5g.
(2) with claim in the step (1) each weight proportion crude drug pulverize after, after water soaks 2 hours with medical material, decoct with high heat then to boiling, reuse slow fire boiling 30 minutes is filtered, filtering residue was with slow fire boiling twice, each 1 hour.Merging filtrate is concentrated into 120 milliliters with filtrate, and adding ethanol ethanol content to the filtrate is 70%, filters, and filtrate recycling ethanol is concentrated into every 1ml and is equivalent to crude drug in whole 1g, filter, and embedding, sterilization promptly is prepared into injection.
(3) drug use method of the present invention: coccidiosis, intramuscular injection, each every 1kg body weight, sheep, pig 0.1-0.2ml/kg, dog, rabbit 0.2ml, 2 times on the one, logotype 3-5 day.
Embodiment 6 medication preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight:
Fructus Cnidii 20g, Radix Dichroae 20g, Radix Sophorae Flavescentis 20g, Radix Scutellariae 10g, Herba Portulacae 10g, Herba Agrimoniae 10g, Radix Angelicae Sinensis 5g, Radix Codonopsis 5g.
(2) with claim in the step (1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours earlier after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into extractum; Filtering residue reuse water extraction 2 times extracted 2.5 hours for the first time, extracted 1.5 hours for the second time, filter, merging filtrate also is condensed into extractum, adds appropriate amount of starch, magnesium stearate at last, granulation, tabletting, every 0.2g (every 1g is equivalent to crude drug in whole 2g) promptly is prepared into tablet.
(3) drug use method of the present invention: coccidiosis, dog, every day the 2-4 sheet, rabbit, fowl 1-2 sheet, logotype 7 days.
For showing the prevention effect of medicine of the present invention to coccidiosis, medicine of the present invention is carried out the clinical observation on the therapeutic effect test, below further set forth the beneficial effect of medicine of the present invention by testing example.
Test example 1
Place: Tianmen City chicken farm, Hubei
On December 3rd, 2008, have nearly 1/3 chicken to occur that spirit is depressed, feather is fluffy, it is slow-witted upright to close one's eyes in Gong plant about 2000 plumages 120 age in days laying hens, and feed intake descends, phenomenons such as amount of drinking water increase.Sick chicken is arranged white loose stool or watery stools, and weight person discharges red hemafecia, is full of mucus in the feces that the part chicken is discharged.Part cockscomb, skin color bleach.Cut open the sick chicken of inspection and find that the intestinal wall outward appearance has bolarious ecchymosis, caecum, small intestinal are hemorrhagic inflammation in various degree, and intestinal mucosa thickens, and ecchymosis or necrosis region are arranged, and is diagnosed as chicken coccidiosis.After the ill chicken of institute picked out, use embodiment 1 preparation medicine of the present invention from the chicken group, adopt the mixed feeding administration, per 1 ton of feedstuff adds medicine 10kg of the present invention, logotype 7 days.Since the 3rd day, the state of an illness began to alleviate, and played the refreshing state of the ill chicken essence of institute, appetite recovery normally on the 5th day.
Test example 2
Place: big northern agricultural group animal health Technical Research Center experimental animal room
Get 240 of healthy 20 Japanese instar chicklings, be divided into 4 groups at random, be respectively the blank group, infect matched group, medicine group of the present invention and diclazuril group.The matched group not administration of falling ill is infected in the not administration of not falling ill of blank group, and medicine group of the present invention is used embodiment 2 preparations, and the diclazuril group is used 0.5% diclazuril pre-mixing agent (autogamy).Except that the blank group, all the other 3 groups are carried out egg capsule with suction pipe and inoculate 10 * 10
4Individual/coccidian oocyst.Begin administration when classical symptom appears in chickling after 24 hours, statistics mortality rate, effective percentage and cure rate see the following form.
This result of the test shows that medicine of the present invention infects chicken coccidiosis notable therapeutic effect, and medicine group curative effect of the present invention slightly is better than 0.5% diclazuril pre-mixing agent.Department of Pharmacy of the present invention pure natural medical is difficult for producing drug resistance, and the scalable body immunity is compared with chemicals, has remarkable advantages.
Test example 3
In June, 2008, Jingshan County, Hubei small towns Liu family raises table hens 500, and early growth is good, and 20 ages in days begin morbidity and constantly dead.Sick chicken essence god is bad, and the feather pine is random, sagging, the paresis of wing, and the eye semi-closure, necking down is slow-witted upright, ataxia.Cockscomb and visual mucosal pallor, draining sample redness just.Cut open inspection sick chicken visible duodenum, the jejunum outward appearance is aubergine and the petechia that differs in size is arranged, caecum swells, and is mixed with blood and cheesy thing, intestinal wall has transparent round speckle, liver surface adularescent or linen downright bad point are diagnosed as chickens infected with eimeria.Use embodiment 4 preparations medicine of the present invention, mix the drink administration, freely drink, logotype is after 7 days, the rehabilitation gradually of sick chicken.
Test example 4
There are 10 30 age in days small weaning pig lethargy, anorexia, diarrhoea in JIUYUE, 2008, Huairou District, Beijing City wild goose certain pig farm, town of dwelling, draws yellow water sample excrement, breath malodor.Use the administration of florfenicol pre-mixing agent spice, logotype commentariess on classics of not getting better in 5th, and 1 piglet death is arranged, and get stool examination, the discovery egg capsule is diagnosed as coccidium infection.Select wherein 3, use embodiment 3 preparations medicine of the present invention, adopt the mixed feeding administration, every 1kg feedstuff adds medicine 10g of the present invention, logotype 7 days.Rose in the 3rd day, sick pig spirit takes a turn for the better, and stops diarrhoea on the 5th day, and it is normal that spiritual appetite is recovered, and used 3 pigletss of powder group to be almost recovered on the 7th day.
Test example 5
On embodiment 4 morbidity pig farms, choose 6 pigletss, use embodiment 5 preparations medicine of the present invention, adopt administered intramuscular, every piglets is injected medicine 1.5ml of the present invention, logotype 5 days every day.Rose in the 3rd day, sick pig stops diarrhoea, and the 5th day, 6 piglet spirit appetite all recovered normal.
Test example 6
In October, 2008, Huairou District Zhang's a white hair pet dog, 2 monthly ages, about 5 kilograms of body weight, it is depressed spirit to occur, and appetite is useless exhausted, draws the sepia loose stool.It is due to the intestinal infection that the dog master doubts, and adopts the amoxicillin to treat glucose fluid infusion, the commentaries on classics of not getting better on the 3rd.Observe the disease dog, become thin, disorderly thick by hair, visual mucosa is grey, gets stool examination, finds egg capsule, is diagnosed as the dog coccidiosis.Adopt embodiment 6 preparations medicine of the present invention, for oral administration, 4 of every days, logotype 5 days.The 3rd day, sick dog spirit took a turn for the better, and the 5th day, sick dog spirit appetite recovered normal.
Claims (7)
1. Anticoccidiosis pharmaceutical composition is characterized in that: it is the preparation that the ingredient by the following weight proportioning is prepared from:
Fructus Cnidii 10-25 part, Radix Dichroae 10-25 part, Radix Sophorae Flavescentis 10-25 part, Radix Scutellariae 8-20 part, Herba Portulacae 8-20 part, Herba Agrimoniae 8-20 part, Radix Angelicae Sinensis 5-15 part, Radix Codonopsis 5-15 part.
2. Anticoccidiosis pharmaceutical composition according to claim 1 is characterized in that: it is the preparation that the ingredient by the following weight proportioning is prepared from:
Fructus Cnidii 15-25 part, Radix Dichroae 15-25 part, Radix Sophorae Flavescentis 15-25 part, Radix Scutellariae 12-18 part, Herba Portulacae 12-18 part, Herba Agrimoniae 12-18 part, Radix Angelicae Sinensis 8-12 part, Radix Codonopsis 8-12 part.
3. Anticoccidiosis pharmaceutical composition according to claim 2 is characterised in that: it is the preparation that the ingredient by the following weight proportioning is prepared from:
20 parts of Fructus Cnidiis, 20 parts of Radix Dichroaes, 20 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Scutellariaes, 15 parts of Herba Portulacaes, 15 parts of Herba Agrimoniaes, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Codonopsis.
4. preparation method as claim 1,2 or 3 described Anticoccidiosis pharmaceutical compositions, it comprises the steps:
(1) takes by weighing each ingredient by weight ratio;
(2) will claim each medicine material maybe will claim after pulverizing, sieving each medicine material after water or alcohol extraction, concentrating, add adjuvant commonly used in the pharmacy again, be prepared from.
5. the preparation method of Anticoccidiosis pharmaceutical composition according to claim 4 is characterized in that the dosage form that makes is: powder, tablet, granule, oral liquid or injection.
6. the Anticoccidiosis pharmaceutical composition described in the claim 1,2 or 3 is in the application that is used to prepare aspect the treatment coccidiostat.
7. the Anticoccidiosis pharmaceutical composition described in the claim 1,2 or 3 is in the application that is used to prepare aspect the treatment coccidiosis of domestic fowls medicine.
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| CN103285255B (en) * | 2013-05-06 | 2014-12-24 | 安徽华澳生物技术有限公司 | Anti-coccidiosis pharmaceutical composition as well as preparation method and use thereof |
| CN104644803A (en) * | 2015-01-16 | 2015-05-27 | 沈阳伟嘉牧业技术有限公司 | Preparation method of poultry anticoccidia traditional Chinese medicine oral liquid |
| CN104623012A (en) * | 2015-03-13 | 2015-05-20 | 石家庄九鼎动物药业有限公司 | Formula of traditional Chinese medicine for treating coccidiosis in chicken and preparation method of oral solution of traditional Chinese medicine |
| CN112006187A (en) * | 2020-10-14 | 2020-12-01 | 甘肃农业大学 | Anti-coccidiosis feed additive for large-scale ecological chicken raising and preparation and use methods thereof |
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| CN101129673A (en) * | 2007-08-17 | 2008-02-27 | 李培英 | Pure traditional Chinese medicine formulated product for preventing and treating coccidiosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101129673A (en) * | 2007-08-17 | 2008-02-27 | 李培英 | Pure traditional Chinese medicine formulated product for preventing and treating coccidiosis |
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| 卢福庄等.中草药防治鸡、兔球虫病的研究进展.《浙江农业学报》.2007,第19卷(第3期),253-257. * |
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Address after: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee after: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee after: Beijing Kegao dabainong Biotechnology Co.,Ltd. Patentee after: BEIJING DABEINONG TECHNOLOGY GROUP Co.,Ltd. Address before: 101407 Beijing city Huairou District Yanqi Economic Development Zone No. 10 North Street Patentee before: Beijing Dabeinong Animal Health Care Technology Co.,Ltd. Patentee before: Beijing Kegao Dabeinong Feedstuff Co.,Ltd. Patentee before: BEIJING DABEINONG TECHNOLOGY GROUP Co.,Ltd. |
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