CN112006187A - Anti-coccidiosis feed additive for large-scale ecological chicken raising and preparation and use methods thereof - Google Patents

Anti-coccidiosis feed additive for large-scale ecological chicken raising and preparation and use methods thereof Download PDF

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CN112006187A
CN112006187A CN202011096848.0A CN202011096848A CN112006187A CN 112006187 A CN112006187 A CN 112006187A CN 202011096848 A CN202011096848 A CN 202011096848A CN 112006187 A CN112006187 A CN 112006187A
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parts
coccidiosis
feed additive
feed
chicken raising
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秦士贞
黄旺洲
秦士娇
史兆国
李金录
王海波
杨敏敏
裴文刚
车育彦
武真邑
龚丽媛
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Gansu Agricultural University
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
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    • A23K50/70Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75Feeding-stuffs specially adapted for particular animals for birds for poultry
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/02Breeding vertebrates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K10/00Animal feeding-stuffs
    • A23K10/30Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/105Aliphatic or alicyclic compounds
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234Cnidium (snowparsley)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/39Convolvulaceae (Morning-glory family), e.g. bindweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention discloses an anti-coccidiosis feed additive for large-scale ecological chicken raising, which comprises the following components in parts by weight: 80-120 parts of hairyvein agrimony, 80-120 parts of purslane, 50-70 parts of sophora flower, 50-70 parts of morning glory seed, 50-70 parts of common cnidium fruit, 50-70 parts of Chinese pulsatilla root, 30-50 parts of honeysuckle, 30-50 parts of sweet wormwood herb and 10-20 parts of garlic. Its preparing process and its application are also disclosed. The coccidian-resistant feed additive for large-scale ecological chicken raising provided by the invention can effectively prevent and treat coccidiosis and has no side effect.

Description

Anti-coccidiosis feed additive for large-scale ecological chicken raising and preparation and use methods thereof
Technical Field
The invention relates to the technical field of coccidiosis resistance of livestock, in particular to an anti-coccidiosis feed additive for large-scale ecological chicken raising and a preparation method and a use method thereof.
Background
Coccidiosis in chickens is a common and very serious parasitic disease of chickens, is an acute epidemic parasitic disease caused by one or more coccidia, and can cause serious loss of poultry meat and egg production. The multiplication of parasites in the small intestine results in tissue damage, decreased feed intake and absorption of nutrients in the feed, dehydration and blood loss. The chicken coccidiosis is parasitic on caecum as the Eimeria tenella is most pathogenic, and is commonly called caecum coccidiosis. The economic losses caused by this are surprising.
Coccidiosis is found to occur frequently in 21-50 day old chicks. The feathers are upright, necked and stood at the beginning of disease, and then the disease condition is serious due to a large amount of damage of intestinal epithelial cells and organism poisoning, so that the symptoms of ataxia, diarrhea with blood and the like appear, the mortality rate is high, and even the whole group is covered. At present, all anticoccidial drugs are western drugs, which have certain influence on animal health.
Disclosure of Invention
The invention aims to provide an anti-coccidiosis feed additive for large-scale ecological chicken raising, which can effectively prevent and treat coccidiosis and has no side effect.
In order to solve the technical problems, the invention adopts the following technical scheme:
the invention relates to an anti-coccidiosis feed additive for large-scale ecological chicken raising, which comprises the following components in parts by weight: 80-120 parts of hairyvein agrimony, 80-120 parts of purslane, 50-70 parts of sophora flower, 50-70 parts of morning glory seed, 50-70 parts of common cnidium fruit, 50-70 parts of Chinese pulsatilla root, 30-50 parts of honeysuckle, 30-50 parts of sweet wormwood herb and 10-20 parts of garlic.
Further, the composition comprises the following components in parts by weight: 80 parts of hairyvein agrimony, 80 parts of purslane, 50 parts of sophora flower, 50 parts of morning glory seed, 50 parts of common cnidium fruit, 50 parts of Chinese pulsatilla root, 30 parts of honeysuckle, 30 parts of sweet wormwood herb and 10 parts of garlic.
Further, the composition comprises the following components in parts by weight: 120 parts of hairyvein agrimony, 120 parts of purslane, 70 parts of sophora flower, 70 parts of morning glory seed, 70 parts of common cnidium fruit, 70 parts of Chinese pulsatilla root, 50 parts of honeysuckle, 50 parts of sweet wormwood herb and 20 parts of garlic.
Further, the composition comprises the following components in parts by weight: 100 parts of hairyvein agrimony, 100 parts of purslane, 60 parts of sophora flower, 60 parts of morning glory seed, 60 parts of common cnidium fruit, 60 parts of Chinese pulsatilla root, 40 parts of honeysuckle flower, 40 parts of sweet wormwood herb and 15 parts of garlic.
A preparation method of an anti-coccidiosis feed additive for large-scale ecological chicken raising comprises the following steps: cleaning the Chinese medicinal materials, sun drying, oven drying, pulverizing into 400 mesh powder of 300 meshes, soaking in vinegar for 100 days, homogenizing at 0-10 deg.C with ultrasonic wave for 10-30 min, and packaging.
Further, the weight ratio of the vinegar to the traditional Chinese medicine is 1:0.8-1.2, preferably 1: 0.9-1.1.
A use method of an anti-coccidiosis feed additive for large-scale ecological chicken raising comprises the following steps: aiming at 15-50 day old chickens, feeding is carried out at intervals, wherein the feed is calculated according to the mass percentage: in the first day, 15-20% of the feed total weight of the feed is added into the feed, and 5-10% is added every other day.
Compared with the prior art, the invention has the beneficial technical effects that:
according to the invention, multiple Chinese herbal medicines are selected to construct a formula, and each Chinese herbal medicine satisfies the compatibility of monarch, minister, assistant and guide medicines and has a synergistic effect, so that coccidiosis is effectively prevented and treated, and the survival rate and the weight gain rate of the chicks are improved.
Detailed Description
Example 1
An anti-coccidiosis feed additive for large-scale ecological chicken raising comprises the following components in parts by weight: 80 parts of hairyvein agrimony, 80 parts of purslane, 50 parts of sophora flower, 50 parts of morning glory seed, 50 parts of common cnidium fruit, 50 parts of Chinese pulsatilla root, 30 parts of honeysuckle, 30 parts of sweet wormwood herb and 10 parts of garlic.
A preparation method of an anti-coccidiosis feed additive for large-scale ecological chicken raising comprises the following steps: cleaning the Chinese medicinal materials, sun drying, oven drying, pulverizing into 400 mesh powder of 300 meshes, soaking in vinegar for 100 days, homogenizing at 0-10 deg.C with ultrasonic wave for 10-30 min, and packaging.
The weight ratio of vinegar to Chinese medicinal materials is 1:0.8-1.2, preferably 1: 0.9-1.1.
A use method of an anti-coccidiosis feed additive for large-scale ecological chicken raising comprises the following steps: aiming at 15-50 days old chickens, the feed is fed for one week as a period, wherein the feed comprises the following components in percentage by mass: on the third day and the fourth day, 15-20% of the feed total weight of the anti-coccidiosis feed additive is added into the feed, and the rest is added with 5-10% of the feed per day; adding 5-10% of the extract after more than 50 days of age.
Example 2
An anti-coccidiosis feed additive for large-scale ecological chicken raising comprises the following components in parts by weight: comprises the following components in parts by weight: 120 parts of hairyvein agrimony, 120 parts of purslane, 70 parts of sophora flower, 70 parts of morning glory seed, 70 parts of common cnidium fruit, 70 parts of Chinese pulsatilla root, 50 parts of honeysuckle, 50 parts of sweet wormwood herb and 20 parts of garlic.
Example 3
An anti-coccidiosis feed additive for large-scale ecological chicken raising comprises the following components in parts by weight: 100 parts of hairyvein agrimony, 100 parts of purslane, 60 parts of sophora flower, 60 parts of morning glory seed, 60 parts of common cnidium fruit, 60 parts of Chinese pulsatilla root, 40 parts of honeysuckle flower, 40 parts of sweet wormwood herb and 15 parts of garlic.
Comparative example 1
An anti-coccidiosis feed additive for large-scale ecological chicken raising comprises the following components in parts by weight: 100 parts of purslane, 60 parts of sophora flower, 60 parts of morning glory seed, 60 parts of common cnidium fruit, 60 parts of Chinese pulsatilla root, 40 parts of honeysuckle flower, 40 parts of sweet wormwood herb and 15 parts of garlic
Comparative example 2
An anti-coccidiosis feed additive for large-scale ecological chicken raising comprises the following components in parts by weight: 100 parts of hairyvein agrimony, 60 parts of sophora flower, 60 parts of morning glory seed, 60 parts of common cnidium fruit, 60 parts of Chinese pulsatilla root, 40 parts of honeysuckle flower, 40 parts of sweet wormwood herb and 15 parts of garlic.
Comparative example 3
An anti-coccidiosis feed additive for large-scale ecological chicken raising comprises the following components in parts by weight: 100 parts of hairyvein agrimony, 60 parts of sophora flower, 60 parts of pharbitis seed, 40 parts of honeysuckle flower, 40 parts of sweet wormwood herb and 15 parts of garlic.
Test example 1
In order to verify the treatment effect of the feed additive on the coccidiosis, 700 chicks infected with the coccidiosis are selected for testing and randomly divided into 7 groups (3 test groups, three comparison groups and 1 comparison group), the daily ration of the comparison group is the conventional feed daily ration without the feed additive, the daily rations of the test groups and the comparison groups are respectively fed by adding the feed additive prepared in the examples 1-3 and the comparative examples 1-3 into the conventional daily ration, and the cure rate of the coccidiosis is determined after the feed additive is continuously used for 7 days.
As a result, it was found that:
the test 0-day coccidiosis infection rates (%) of examples 1, 2, 3, 1, 2, 3 and 3 were 100, respectively; test 3 the coccidiosis infection rate (%) was 23, 25, 20, 40, 42, 38, 100; the coccidiosis infection rate (%) at 5 days of the test is 1, 0, 12, 10, 9 and 100; the coccidiosis infection rate (%) at 7 days of the test was 0, 5, 6, 100.
The daily gain rate of the samples of example 1, example 2 and example 3 is improved by 5-10% compared with the samples of comparative example 1, comparative example 2 and comparative example 3. The daily gain rate of the embodiment 1, the embodiment 2 and the embodiment 3 is improved by 30-40 percent compared with the comparative example.
The use effect is as follows: compared with the control group and the control group, the infection rate of the coccidia in the examples 1-3 on the 3 rd day of the test is only 20-25%, the infection rate is 0-1 by the 5 th day, and the three examples can be completely cured by the seventh day, and the effect of preventing and treating the coccidia is obvious compared with the control group and the control group. Meanwhile, the daily weight gain rate is obviously improved.
Test example 2
In order to verify that the additive has no side effect on coccidiosis, 30 chicks in good state are selected for testing and randomly divided into 3 groups, the additives prepared according to the examples 1-3 are added into the conventional daily ration for feeding, and the additive is continuously used for 7 days, and the influence on immune organs is determined.
As a result, it was found that: it can effectively improve the immunity of each chicken without any other side effect or adverse effect.
The above-described embodiments are merely illustrative of the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements of the technical solutions of the present invention can be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are within the scope of the present invention defined by the claims.

Claims (8)

1. The anti-coccidium feed additive for large-scale ecological chicken raising is characterized by comprising the following components in parts by weight: 80-120 parts of hairyvein agrimony, 80-120 parts of purslane, 50-70 parts of sophora flower, 50-70 parts of morning glory seed, 50-70 parts of common cnidium fruit, 50-70 parts of Chinese pulsatilla root, 30-50 parts of honeysuckle, 30-50 parts of sweet wormwood herb and 10-20 parts of garlic.
2. The anti-coccidiosis feed additive for large-scale ecological chicken raising according to claim 1, which is characterized by comprising the following components in parts by weight: 80 parts of hairyvein agrimony, 80 parts of purslane, 50 parts of sophora flower, 50 parts of morning glory seed, 50 parts of common cnidium fruit, 50 parts of Chinese pulsatilla root, 30 parts of honeysuckle, 30 parts of sweet wormwood herb and 10 parts of garlic.
3. The anti-coccidiosis feed additive for large-scale ecological chicken raising according to claim 1, which is characterized by comprising the following components in parts by weight: 120 parts of hairyvein agrimony, 120 parts of purslane, 70 parts of sophora flower, 70 parts of morning glory seed, 70 parts of common cnidium fruit, 70 parts of Chinese pulsatilla root, 50 parts of honeysuckle, 50 parts of sweet wormwood herb and 20 parts of garlic.
4. The anti-coccidiosis feed additive for large-scale ecological chicken raising according to claim 1, which is characterized by comprising the following components in parts by weight: 100 parts of hairyvein agrimony, 100 parts of purslane, 60 parts of sophora flower, 60 parts of morning glory seed, 60 parts of common cnidium fruit, 60 parts of Chinese pulsatilla root, 40 parts of honeysuckle flower, 40 parts of sweet wormwood herb and 15 parts of garlic.
5. The method for preparing the anti-coccidia feed additive for large-scale ecological chicken raising as claimed in any one of claims 1-4, wherein the preparation method comprises the steps of selecting the traditional Chinese medicines according to the formula proportion, drying in the sun, drying by baking, crushing into 300-400 mesh fine powder, adding into vinegar, soaking for 100 days, homogenizing by ultrasonic waves at the temperature of 0-10 ℃ for 10-30 minutes, and subpackaging to obtain the finished product.
6. The method of claim 5, wherein the weight ratio of vinegar to herbs is 1: 0.8-1.2.
7. The method of claim 6, wherein the weight ratio of vinegar to herbs is 1: 0.9-1.1.
8. The use method of the anticoccidial feed additive for scale ecological chicken raising according to any one of claims 1 to 4, wherein the feed is fed to 15-50-day-old chickens at intervals, wherein the feed comprises the following components in percentage by mass: in the first day, 15-20% of the feed total weight of the feed is added into the feed, and 5-10% is added every other day.
CN202011096848.0A 2020-10-14 2020-10-14 Anti-coccidiosis feed additive for large-scale ecological chicken raising and preparation and use methods thereof Pending CN112006187A (en)

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Publication number Priority date Publication date Assignee Title
CN101670005A (en) * 2009-09-29 2010-03-17 北京大北农动物保健科技有限责任公司 Anticoccidiosis pharmaceutical composition and preparation method and use thereof
CN102552458A (en) * 2010-12-16 2012-07-11 天津中敖生物科技有限公司 Chinese medicine composition for treating chicken coccidiosis and preparation method thereof
CN103211096A (en) * 2013-05-14 2013-07-24 山东新希望六和集团有限公司 Anti-coccidium traditional Chinese medicine feed additive
CN103495091A (en) * 2013-10-22 2014-01-08 山东新希望六和集团有限公司 Traditional Chinese medicine immune stimulant for preventing Eimeria tenella infections
CN104161946A (en) * 2013-08-30 2014-11-26 郑州后羿制药有限公司 Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof
CN104208238A (en) * 2013-09-29 2014-12-17 郑州后羿制药有限公司 Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof
CN107308235A (en) * 2017-06-27 2017-11-03 齐全农牧集团股份有限公司 A kind of Chinese medicine composition and preparation method for preventing and treating chicken coccidiasis
CN108392580A (en) * 2018-04-20 2018-08-14 佛山迁宇科技有限公司 A kind of feed addictive and preparation method thereof of prevention chicken coccidiasis
CN109480087A (en) * 2018-12-13 2019-03-19 双胞胎(集团)股份有限公司 A kind of feed addictive of anticoccidial

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101670005A (en) * 2009-09-29 2010-03-17 北京大北农动物保健科技有限责任公司 Anticoccidiosis pharmaceutical composition and preparation method and use thereof
CN102552458A (en) * 2010-12-16 2012-07-11 天津中敖生物科技有限公司 Chinese medicine composition for treating chicken coccidiosis and preparation method thereof
CN103211096A (en) * 2013-05-14 2013-07-24 山东新希望六和集团有限公司 Anti-coccidium traditional Chinese medicine feed additive
CN104161946A (en) * 2013-08-30 2014-11-26 郑州后羿制药有限公司 Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof
CN104208238A (en) * 2013-09-29 2014-12-17 郑州后羿制药有限公司 Traditional Chinese medicine composition for treating chicken coccidiosis and preparation method thereof
CN103495091A (en) * 2013-10-22 2014-01-08 山东新希望六和集团有限公司 Traditional Chinese medicine immune stimulant for preventing Eimeria tenella infections
CN107308235A (en) * 2017-06-27 2017-11-03 齐全农牧集团股份有限公司 A kind of Chinese medicine composition and preparation method for preventing and treating chicken coccidiasis
CN108392580A (en) * 2018-04-20 2018-08-14 佛山迁宇科技有限公司 A kind of feed addictive and preparation method thereof of prevention chicken coccidiasis
CN109480087A (en) * 2018-12-13 2019-03-19 双胞胎(集团)股份有限公司 A kind of feed addictive of anticoccidial

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